KR101388052B1 - Composition for cosmetics comprising gluconolactone and lactobionic acid for skin exfoliation, skin whitening or improvement of skin tone - Google Patents

Abstract

The present invention relates to a cosmetic composition. More specifically, the present invention provides a cosmetic composition having excellent skin exfoliation, skin whitening or skin tone improvement effects, including 2% by weight of gluconolactone and 4% by weight of lactobionic acid.

Description

Composition for cosmetics comprising gluconolactone and lactobionic acid for skin exfoliation, skin whitening or improvement of skin tone}

The present invention relates to a cosmetic composition. More specifically, the present invention includes gluconolactone and lactobionic acid in a specific weight ratio, thereby providing a cosmetic composition having excellent skin exfoliation, skin whitening, or skin tone improvement.

The most important role of the skin is to act as a defensive barrier to protect the skin from external bacterial invasion and damage while preventing heat and moisture loss from the inside.

The skin is composed of several layers, the outermost of which is called the epidermis, and is divided into subdivided layers of dermis and subcutaneous fat.

The epidermis is subdivided into stratum corneum, granule layer, pole layer, and basal layer. Epidermal cells generated in basal layer rise to granule layer over 14 days, and keratinahlin in the granule layer starts keratinization. The body fluids in the cells have already escaped and the cells are flattened, and keratinization proceeds. The nucleus, cytoplasm and organelles of the cells are degenerated, replaced by keratin allin and changed back to Eleidin. The life cycle of the cell ends and the stratum corneum is pushed up. The stratum corneum is composed of differentiated epidermal cells (skin cells) and the intercellular lipids (Skin Lipid) that fill the gaps, which protects the body from outwards and protects the body from external physical, chemical and biological stimuli. Do it. The keratinocytes are connected by a protein called desmosome, and as they rise up the stratum corneum, the desmosome is broken down to weaken the cohesion between keratinocytes and finally the keratinocytes are separated from the skin. In normal skin, the stratum corneum consists of 15 to 20 layers, and it takes 15 to 20 days to separate completely.

However, as we age, skin components, such as the epidermis, dermis, and subcutaneous tissue, become thinner, the moisture content of the skin decreases drastically, and the skin loses its elasticity due to changes in the extracellular matrix (ECM) component that gives the skin elasticity. Wrinkles may occur, and the separation of the stratum corneum will be later than normal, resulting in thickening of the stratum corneum (stratum corneum) and loss of vitality of the skin.

The stratum corneum stratification is mainly due to the decrease in the moisturizing power of the skin, the production and deactivation of desmosome degrading enzymes, and the decrease of cellular activity. Artificially thinning the stratum corneum thickened by these internal and external factors externally increases the activity or regeneration of living cells under the stratum corneum, resulting in softening of the skin and the effects of wrinkle removal, acne suppression, and treatment. There is a lot of research to solve the keratin stratification within the range that is not possible.

To relieve keratinization, physically rub the skin or use chemical dermabrasion. In particular, chemical peeling has additional effects such as fine wrinkle improvement, rough skin relief, and blemish removal. Substances used for chemical peeling have been mainly used alpha-hydroxy acid (AHA) and beta-hydroxy acid (BHA).

Among them, alpha hydroxy acid (AHA: α-Hydroxy Acid) is a compound in which the alcohol group (Alcohol Group) or the hydroxyl group (Hydroxy Group) is added to the carbon at the α position of the carboxylic acid (Carboxylic Acid). Lower keratin to remove keratin or promote the formation of new cells to shorten the period of keratinization process, which is longer as the skin ages by promoting the activity of skin cells to improve the skin. In addition, it stimulates the production of collagen and elastin by fibroblasts to make the skin elastic and soft and to promote the production of mucopolysaccharide, an important extracellular matrix component of the dermis. Improves skin moisturizing Development of a cosmetic composition that removes dead skin cells using alpha hydroxy acid as an active ingredient is actively underway. Refer to Korean Patent No. 10-0731700 and the like. However, alpha hydroxy acid has a problem that the skin irritation is large, it can be used for exfoliation purposes.

Related prior arts include Korean Patent Publication No. 2011-0067863 (published date: June 22, 2011, cosmetic composition for exfoliating skin).

An object of the present invention is to provide a cosmetic composition excellent in skin exfoliation, skin whitening or skin tone improvement effect.

The cosmetic composition of the present invention may include a mixture comprising 2% by weight of gluconolactone and 4% by weight of lactobionic acid as an active ingredient.

In one embodiment, the cosmetic composition may be used for skin exfoliation, skin whitening or skin tone improvement.

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The cosmetic composition according to the present invention acts on the keratinocytes, which are the outermost layers of the skin epidermis, and has excellent skin exfoliation effect. There is this. Therefore, it can be usefully applied in cosmetic preparation for skin exfoliation, pigmentation and skin tone improvement.

1 is a photograph taken with APHRODITE of PSI WELL-BEING company to improve the exfoliation of skin before and after use of Example 4.
Figure 2 is a photograph taken with PAN WELL-BEING JANUS the degree of improvement of skin tone before and after use of Example 4.
Figure 3 is a photograph taken with JANUS of PSI WELL-BEING, including the skin whitening freckles improvement before and after use of Example 4.

The cosmetic composition of the present invention may include a mixture containing gluconolactone and lactobionic acid in a weight ratio of 1: 1.5 to 1: 2.0 as an active ingredient. Within this range, the skin exfoliation effect is excellent, and the effect on skin whitening or pigmentation and skin tone improvement can be further enhanced. Preferably, gluconolactone: lactobionic acid may be included in a weight ratio of 1: 2.0.

Gluconolactone is an artificial compound used as a food additive and has a soft sour taste. It reacts less at low temperatures and is used to lower the pH to raw materials used in food products by generating uniform bubbles.

Glucolactone is effective for photoaging and sensitive skin, improves moisture moisturizing effect and gives conditioning effect to skin barrier, and is effective for wrinkle area, skin firming and pore management.

Lactobionic acid is PHA derived from Milk Sugar, and is a potential antioxidant with excellent water supply ability due to its strong ability to attract and bind water molecules. This ingredient reduces the appearance of wrinkles and wrinkles, strengthens skin tissue, reduces aging, and inhibits the function of destructive enzymes (MMP) that reduce the ability to maintain skin tissue and strength. Protects against damage by

Gluconolactone may be included in 1-20% by weight of the cosmetic composition, lactobionic acid in 1-40% by weight. Within this range, it can be effective in removing skin exfoliation, improving pigmentation, improving wrinkles and skin tone without skin irritation.

Preferably, 1-10% by weight of gluconolactone in the cosmetic composition, 1-20% by weight of lactobionic acid, more preferably 1-4% by weight of gluconolactone and 2-8% by weight of lactobionic acid in the cosmetic composition. May be included as a%.

The mixture comprising gluconolactone and lactobionic acid may be included in an amount of 0.01-40% by weight in the cosmetic composition. Within this range, it is possible to exert enhanced skin exfoliation and skin tone improving effects without skin irritation. Preferably it may be included in 1 to 20% by weight.

The cosmetic composition may be used for exfoliating skin, whitening skin or improving skin tone. The cosmetic composition of the present invention has a remarkable effect on skin exfoliation, skin pigmentation skin and skin tone improvement.

The cosmetic composition may be used in addition to gluconolactone and lactobionic acid, in addition to known natural ingredients or other ingredients for skin exfoliation or skin tone improvement and wrinkle improvement in a range that does not inhibit the effective activity.

In addition, the composition may be molded into a specific formulation, including components conventionally added to cosmetic compositions, such as conventional auxiliaries or carriers such as stabilizers, solubilizers, vitamins, pigments and flavorings.

The cosmetic composition of the present invention can be prepared into any formulation conventionally produced in the art. For example, they may be formulated as solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays, But is not limited thereto. More specifically, the present invention relates to a cosmetic composition comprising: a softening lotion, a nutritional lotion, a nutritive cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray, a powder, a fact, a lip gloss, a lipstick, . ≪ / RTI > (O / W), water-in-oil (W / O), water-in- W / O) and water-in-oil-in-water (W / O / W)

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

Preferably, the cosmetic composition of the present invention is selected from the group consisting of polysorbate 60, sorbitan sesquioleate, stearic acid, cetyl alcohol, squalane, glycerin, butylene glycol, arginine, carbomer, tocopheryl acetate, 1,2- Hexanediol, purified water, and the like.

Hereinafter, the configuration and operation of the present invention through the preferred embodiment of the present invention will be described in more detail. However, the following examples are provided to aid understanding of the present invention, and the scope of the present invention is not limited to the following examples. The contents not described here are sufficiently technically inferior to those skilled in the art, and a description thereof will be omitted.

Example  1 ~ 6 lessons Comparative Example  1-5.

Using the components and contents shown in Table 1 below to prepare a cosmetic composition of Example 1-6 and Comparative Example 1-5 according to a conventional method.

Component ＼ Content (wt%) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Gluconolactone 1.0 3.0 4.0 2.0 2.0 3.0 1.0 2.0 4.0 3.0 2.0 Lactobionic acid 2.0 6.0 8.0 4.0 3.0 4.5 0.5 2.0 2.0 3.0 5.0 Polysorbate 60 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Sorbitan sesquioleate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Stearic acid 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Cetyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Squalane 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 glycerin 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Butylene glycol 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Arginine 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Carbomer 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Tocopheryl acetate 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 1,2-hexanediol 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Purified water Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Sum 100 100 100 100 100 100 100 100 100 100 100

Using the cosmetic composition prepared in the compositions of Examples 1 to 6 and Comparative Examples 1 to 5, the cosmetic composition was prepared by a conventional cream manufacturing method.

Test Example 1. Evaluation of pigmentation skin and skin tone improvement effect such as exfoliation of skin, blemishes and freckles

When the cosmetic composition (cream) of Examples 1 to 6 and Comparative Examples 1 to 5 were used, 20 women aged 18 to 40 years were measured to measure pigmentation skin and skin tone improvement, such as exfoliation of skin, blemishes, and freckles. The results are shown in Table 2 after one week of use for each product. The test was conducted with the lowest score of 1 and the highest score of 5, and the average value of the evaluation results was obtained.

Evaluation items Example
One Example
2 Example
3 Example
4 Example 5 Example 6 Comparative Example
One Comparative Example
2 Comparative Example
3 Comparative Example
4 Comparative Example
5 Exfoliation effect 4.2 3.9 3.8 4.5 3.5 3.6 2.5 2.6 2.3 2.8 2.3 Blemish, freckle
Removal effect 3.0 3.5 4.0 4.2 3.0 3.0 1.8 2.0 2.0 2.3 2.5 Skin tone improvement effect 4.5 4.3 4.3 4.7 4.0 3.8 2.0 2.1 2.2 2.5 2.5 Moisturizing effect 3.8 3.5 3.6 3.9 3.0 3.2 3.0 3.1 3.0 3.1 3.0 Whitening effect 3.6 3.8 4.0 4.2 3.4 3.3 2.5 2.5 2.2 2.1 2.3

As can be seen in Table 2, when using Examples 1 to 6 it was evaluated that the exfoliation effect, skin tone improvement effect, moisturizing effect and whitening effect than Comparative Examples 1-5.

Test Example 2 Comparison of skin exfoliation and skin tone improvement

In Example 4 and Comparative Example 4, the difference in the degree of skin exfoliation and skin tone improvement was compared.

Specifically, 20 patients in the clinical group were applied to the same person, 20 for each of Example 4 and 20 for each of the Comparative Example 4 to spread the cosmetic, and applied twice a day (for morning / evening) for 6 days. After that, the satisfaction of skin exfoliation, skin tone and skin whitening improvement were examined, and the skin condition of each subject was photographed or measured by JANUS of PSI WELL-BEING company. The results are shown in Table 3 and FIGS. 1 to 3.

division Skin exfoliation and skin tone improvement persons ratio(%) Example 4 very good 12 60 satisfied 6 30 usually One 5 Slightly dissatisfied One 5 dissatisfaction 0 0 Comparative Example 4 very good 8 40 satisfied 7 35 usually 3 15 Slightly dissatisfied One 5 dissatisfaction One 5

As a result, as shown in Table 2 and Figures 1 to 3, when using the cosmetic composition of Example 4 containing the composition according to the present invention, the satisfaction with the skin exfoliation and skin tone improvement effect is higher than the commercial products appear.

Test Example 3 Skin Irritation Test

The skin patch test was carried out to investigate the skin irritation test for each of the cosmetics prepared with the compositions of Examples 1-6 and Comparative Examples 1-5. The subjects were selected as a person with no skin disease at the test site of 15 ~ 30 years old. After wiping the upper part of the patch with 70% ethanol and drying, 0.1g of the product was added to the upper arm for 24 hours, the skin reaction was examined within 1 hour after the patch was removed, and the next day (after 48 hours) was examined again. . Skin response determinations were made according to the following test criteria. The skin patch test results are shown in Table 4.

* Skin reaction test standard

- no response

± weak positive reaction (erythema)

+ Positive (erythema)

++ strong positive reaction (erythema, edema)

+++ Severe positive reactions (erythema, edema, blisters)

Prescription  Number of test persons (persons) Judgment result - ± + ++ +++ Example 1 18 16 2 0 0 0 Example 2 18 16 One One 0 0 Example 3 18 17 One 0 0 0 Example 4 18 17 One 0 0 0 Example 5 18 16 One One 0 0 Example 6 18 15 2 One 0 0 Comparative Example 1 18 14 2 2 0 0 Comparative Example 2 18 13 2 3 0 0 Comparative Example 3 18 13 2 2 One 0 Comparative Example 4 18 13 3 One 0 0 Comparative Example 5 18 12 3 One One 0

As shown in Table 4, the cosmetics produced by the manufacturing method of the present invention was shown that the Examples are almost no skin irritation compared to the comparative example.

Test Example 4. Stability Evaluation

In order to measure the stability to the degree of separation and discoloration for the cosmetics (cream) of Examples 1 to 6 and Comparative Examples 1 to 5, the refrigerator maintained at a constant temperature of 4 ℃ ℃ constant temperature maintained at 45 ℃ and 25 ℃ And in Example 1 and Comparative Example composition in daylight conditions in a sample container and stored for 8 weeks to compare and measure the degree of separation and discoloration, the results are shown in Table 5 below. At this time, the degree of separation and discoloration of the product was evaluated by classifying into the following six grades.

Evaluation items Degree of separation and discoloration Example
One Example
2 Example
3 Example
4 Example 5 Example 6 Comparative Example
One Comparative Example
2 Comparative Example
3 Comparative Example
4 Comparative Example 5 45 ° C One 0 0 0 One One One One 2 One One 25 ℃ 0 0 0 0 0 0 0 0 0 0 0 4 ℃ 0 0 0 0 0 0 0 0 0 0 0 daylight 0 One 0 0 0 One One One 0 2 One

* Separation and discoloration evaluation criteria:

0: no change, 1: very little separation (discoloration), 2: little separation (discoloration)

3: a little severe separation (discoloration), 4: severely separation (discoloration), 5: extremely severe separation (discoloration) As can be seen in Table 5, it can be seen that the embodiment is a stable formulation with less discoloration and separation phenomenon.

Claims (6)

Cosmetic composition comprising a mixture comprising 2% by weight of gluconolactone and 4% by weight of lactobionic acid as an active ingredient.
The cosmetic composition according to claim 1, wherein the cosmetic composition is used for exfoliating skin, whitening skin or improving skin tone. delete delete The composition of claim 1 wherein the cosmetic composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Cosmetic composition, characterized in that it has a formulation selected from the group. According to claim 1, wherein the cosmetic composition is Oil-in-Water (O / W), Water-in-Oil (W / O), Water-in-Silicone (W / S), Oil-in-Water-in -Oil (O / W / O) and Water-in-Oil-in-Water (W / O / W) cosmetic composition, characterized in that the formulation.

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