CN116617108A - Anti-wrinkle composition and anti-wrinkle cosmetic - Google Patents
Anti-wrinkle composition and anti-wrinkle cosmetic Download PDFInfo
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- CN116617108A CN116617108A CN202310645929.9A CN202310645929A CN116617108A CN 116617108 A CN116617108 A CN 116617108A CN 202310645929 A CN202310645929 A CN 202310645929A CN 116617108 A CN116617108 A CN 116617108A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an anti-wrinkle composition and an anti-wrinkle cosmetic. The anti-wrinkle composition comprises, by weight, 0.01-20 parts of instant long-term anti-wrinkle composition and 0.01-15 parts of composition for promoting collagen production and strengthening euepidermic connection; the instant long acting anti-wrinkle composition comprises: 0.01-4 parts of snake venom peptide, 0.01-5 parts of conopeptide, 0.01-4.5 parts of acetyl tetrapeptide-2, 0.5-20 parts of L-proline-lactic acid and 0.5-20 parts of L-proline-glycerol; the composition for promoting collagen production and strengthening the connection of the dermis comprises: 5-20 parts of betaine glycerol, 0.01-6 parts of palmitoyl tripeptide-5, 0.01-1 part of hexapeptide-9 and 0.01-2 parts of hexapeptide-11. The invention utilizes the difference of action mechanisms of the instant long-acting anti-wrinkle composition and the composition for promoting collagen generation and strengthening the connection of the dermis to carry out compound synergy, so that the skin can not only have remarkable instant long-acting effect, but also promote the generation of facial collagen, inhibit collagen decomposition and promote the connection of the dermis, thereby realizing omnibearing anti-wrinkle.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to an anti-wrinkle composition and an anti-wrinkle cosmetic.
Background
Skin aging is classified into natural aging and aging caused by environmental factors. Natural aging refers to aging of skin cells over time, reduction of collagen content in skin, disorder of collagen and elastin fibers, reduction of fibroblast number in skin, and the like, and wrinkling, color spots and slackening of skin; environmental pollution, ultraviolet ray stimulation, bad eating habits, smoking, drinking and improper skin care modes can also accelerate skin aging, and phenomena such as fine lines, looseness and the like can occur in advance.
Although the aging is unavoidable, the aging process can be delayed by medical and cosmetic use and other modes, and the existing wrinkle removing method on the market is as follows:
1. by injecting a small amount of botulinum toxin type A, however, complications of the method seriously occur, which is a serious hidden trouble for skin health embedding;
2. the peptide and the peptide composition are compounded to realize the effects of tightening and resisting wrinkles, but the active ingredients cannot be well absorbed by skin, only stay on the surface, and have poor anti-wrinkle effect;
3. the polydimethylsiloxane is adopted to fill pores and gaps in the skin, so that the effect of immediately removing wrinkles is achieved, but the method can treat the symptoms, does not treat the root cause, and can block pores after long-time use, so that the skin is stimulated, and the phenomena of acne or allergy are caused;
4. the natural plant-derived components are adopted to achieve the effects of immediately and long-acting wrinkle removal, but the effects are slow to take effect and cannot achieve the effects of instant effect;
5. retinol products are used for resisting wrinkle, and although the efficacy is outstanding, high concentration retinol can cause irritation to skin, and the stability is poor and the bioavailability is limited.
Therefore, the product with good permeation promoting effect and high bioavailability is required in the current market, and can simultaneously achieve the purposes of timely and long-acting wrinkle removal, ageing resistance, skin elasticity recovery, skin dermis linking reinforcement.
Disclosure of Invention
The invention aims to provide a product which can simultaneously achieve the effects of immediately and long-acting wrinkle removal and aging resistance, skin elasticity recovery, skin true epidermis link reinforcement, good permeation promotion effect and high bioavailability.
The technical scheme of the invention is as follows:
the invention provides an anti-wrinkle composition, which comprises, by weight, 1-20 parts of an instant long-term anti-wrinkle composition and 1-15 parts of a composition for promoting collagen production and strengthening euepidermic connection;
the instant long acting anti-wrinkle composition comprises: 0.01-4 parts of snake venom peptide, 0.01-5 parts of conopeptide, 0.01-4.5 parts of acetyl tetrapeptide-2, 0.5-20 parts of L-proline-lactic acid and 0.5-20 parts of L-proline-glycerol;
the composition for promoting collagen production and strengthening the connection of the dermis comprises: 5-20 parts of betaine glycerol, 0.01-6 parts of palmitoyl tripeptide-5, 0.01-1 part of hexapeptide-9 and 0.01-2 parts of hexapeptide-11.
The anti-wrinkle composition provided by the invention comprises an instant long-acting anti-wrinkle composition and a composition for promoting collagen generation and strengthening euepidermic connection, and the two compositions are used for compounding and synergistic interaction by different action mechanisms, so that the skin can be obvious in instant long-acting effect, the generation of facial collagen can be promoted, the collagen decomposition can be inhibited, and the euepidermic connection can be promoted, thereby realizing omnibearing anti-wrinkle. The cosmetic prepared from the anti-wrinkle composition has good permeability and better skin absorption effect, can lighten skin fine lines, increase skin elasticity, compact skin and make the anti-wrinkle effect more obvious and comprehensive.
For a better understanding of the present invention, a detailed description is provided below in connection with specific mechanisms.
The conopeptide can block the current conduction of nerve muscles so as to instantaneously fade wrinkles, particularly, the blocking rate can reach more than 90 percent aiming at a channel Na V1.4 of the muscles, not only can play a role of blocking, but also can keep certain signal flow and inhibit the contraction of the muscles, but also can not tighten and rigidify, thereby playing the role of instantaneously removing wrinkles.
Acetyl tetrapeptide-2 can up-regulate gene expression related to collagen synthesis and focal adhesion, induce elastin and type I collagen synthesis, thereby increasing skin firmness and reconstructing epidermis structure.
The snake venom peptide mainly acts on a protruding posterior model and is an antagonist for reversible muscle nicotinic acetylcholine receptor (nmAChR), and the epsilon subunit of the nmAChR is combined to block the combination of acetylcholine and the receptor, so that the receptor is finally blocked, sodium ions cannot be taken in a blocked state, depolarization cannot be carried out, nerve excitation transmission is blocked, and muscle is relaxed, so that wrinkles are smoothed, and expression of facial expression is not influenced.
Palmitoyl tripeptide-5 is the earliest and most widely applied cosmetic peptide in peptide series, and has excellent synthesis performance of promoting collagen and elastin in dermis, and collagen peptide Siped COLL.02 stimulates skin collagen synthesis through tissue growth factors, so that the purposes of smoothing wrinkles and tightening skin and resisting wrinkles are achieved.
Hexapeptide-9, also known as keli peptide, is composed of six amino acids, can exert a strong anti-aging effect by acting on epidermis, dermis-epidermis junction (DEJ) and dermis, and can play a very good role in weakening and preventing skin wrinkles such as head lines, fish tail lines, stature lines and the like.
Hexapeptide-11, a naturally occurring polypeptide, is isolated from a yeast fermentation broth. It can promote synthesis of collagen, elastin and extracellular matrix components, and has effects of resisting wrinkle and aging.
L-proline-lactic acid, L-proline-glycerol and betaine glycerol are all supermolecular ionic liquids. The betaine and the glycerol, the L-proline and the lactic acid, and the L-proline and the glycerol are tightly combined through intermolecular forces by a supermolecule improvement technology to form the supermolecule ionic liquid, so that the effect of 1+1>2 is realized. After the supermolecular ionic liquid is formed, the activity of the peptide is protected, the skin permeation of the peptide is promoted, the peptide is slowly released, the residence time of the peptide on the skin is prolonged, the absorption and utilization rate is increased, and the percutaneous absorption and bioavailability of the peptide are effectively improved.
In one embodiment, the anti-wrinkle composition consists of 1-20 parts of an instant long-lasting anti-wrinkle composition and 1-15 parts of a composition that promotes collagen production and strengthens the euepidermal junction;
the instant long-acting anti-wrinkle composition comprises the following raw materials in parts by weight: 0.304 part of snake venom peptide, 0.016 part of conopeptide, 0.15 part of acetyl tetrapeptide-2, 1 part of L-proline-lactic acid and 1 part of L-proline-glycerol;
the composition for promoting collagen production and strengthening the connection of the dermis is prepared from the following raw materials in parts by weight: 0.105 part of palmitoyl tripeptide-5, 0.205 part of hexapeptide-9, 0.2 part of hexapeptide-11 and 13.2 parts of betaine glycerol.
The invention provides an anti-wrinkle cosmetic, which comprises the anti-wrinkle composition and auxiliary materials acceptable in cosmetics.
In one embodiment, the cosmetic comprises one of a skin softening lotion, an essence, an emulsion, a face cream, an eye cream, a facial mask, an eye mask, and a facial cleanser.
The invention provides an anti-wrinkle essence, which comprises an anti-wrinkle composition, a humectant, an emollient, a pH regulator, a thickener, a preservative, a chelating agent and deionized water.
In one embodiment, the humectant is sodium hyaluronate, glucosyl glycerate, butylene glycol, glycerin, hexylene glycol, hydrogenated lecithin S-10; the emollient is vaseline, VE, DOWSIL 9509; the pH regulator is arginine; the thickener is SEPIMAX ZEN and EMT-10; the preservative is phenoxyethanol; the chelating agent is EDTA-2Na.
In one embodiment, the anti-wrinkle essence comprises, in parts by weight, 1-20 parts of an instant long-acting anti-wrinkle composition, 1-15 parts of a collagen production promoting composition, 0.03-0.035 parts of conventional HA, 0.03-0.035 parts of nanoscale HA, 2-2.05 parts of glyceroglycosides, 2-2.05 parts of butanediol, 3-3.05 parts of glycerol, 0.5-0.55 parts of hexanediol, 0.8-0.85 parts of hydrogenated lecithin S-10, 0.5-0.55 parts of vaseline, 0.2-0.25 parts of VE, 8-8.05 parts of DOWSIL 9509, 0.1-0.15 parts of arginine, 0.5-0.6 parts of SEPIMAX ZEN, 0.3-0.35 parts of EMT-10, 0.4-0.45 parts of phenoxyethanol, 0.03-0.05 parts of EDTA-2Na and 10-80 parts of deionized water.
The invention provides a preparation method of an anti-wrinkle essence, which comprises the following steps in parts by weight:
s1, adding 0.03-0.05 part of EDTA-2Na, 0.5-0.6 part of SEPIMAX ZEN, 0.3-0.35 part of EMT-10, 3-3.05 parts of glycerol, 2-2.05 parts of butanediol, 2-2.05 parts of glyceroglycosides, 0.03-0.035 part of HA (conventional) and 0.03-0.035 part of HA (nano) into 10-80 parts of deionized water, uniformly stirring, and heating for dissolving to obtain a solution a;
s2, placing 8-8.05 parts of DOWSIL 9509, 0.5-0.55 parts of vaseline, 0.2-0.25 parts of VE and 0.8-0.85 parts of hydrogenated lecithin S-10 into a clean container (such as a beaker), and heating until the hydrogenated lecithin S-10 is completely dissolved to obtain a solution b;
s3, adding the solution b obtained in the step S2 into the solution a obtained in the step 1, and homogenizing until emulsification is completed to obtain a solution c;
s4, adding 0.4-0.45 part of phenoxyethanol and 0.5-0.55 part of hexanediol into the solution c, stirring and cooling to obtain a material d;
s5, adding 1-20 parts of the instant long-term anti-wrinkle composition, 1-15 parts of the collagen production promoting composition and 0.1-0.15 part of arginine into the material d obtained in the step 4, and uniformly stirring to obtain the anti-wrinkle essence.
The invention provides an anti-wrinkle eye mask essence, which comprises an anti-wrinkle composition, an algae extract, a humectant, a pH regulator, a thickener, an antioxidant and deionized water.
The algae extract has the effects of supplementing water and relieving, wherein the fucoidan has strong activity of scavenging superoxide anion free radical and hydroxyl free radical. The application of the composition in cosmetics can help to remove free radicals of human skin and resist skin aging.
In one embodiment, the humectant is HZ1706, jojoba oil, glycerin, betaine, butylene glycol, hexylene glycol; the pH regulator is arginine; the thickener is sclerotium rolfsii, 250HHR; the antioxidant is p-hydroxyacetophenone.
In one embodiment, the anti-wrinkle eye mask essence comprises, by weight, 1-20 parts of an instant long-lasting anti-wrinkle composition, 1-15 parts of a collagen production promoting composition, 1-10 parts of an algae extract, 3-3.05 parts of HZ1706, 2-2.05 parts of Porphyra oil, 2-2.05 parts of glycerol, 0.5-0.55 parts of betaine, 3-3.05 parts of butanediol, 0.5-0.55 parts of hexanediol, 0.16-0.165 parts of arginine, 0.15-0.16 parts of sclerotium gum, 0.2-0.25 parts of 250HHR, 0.5-0.55 parts of p-hydroxyacetophenone, and 10-80 parts of deionized water.
The invention provides a preparation method of an anti-wrinkle eye mask essence, which comprises the following steps in parts by weight:
s1, adding 0.15-0.16 part of sclerotium rolfsii, 0.2-0.25 part of 250HHR, 3-3.05 parts of HZ1706, 2-2.05 parts of jojoba oil, 2-2.05 parts of glycerin, 0.5-0.55 part of betaine, 3-3.05 parts of butanediol, 0.5-0.55 part of hexanediol and 0.5-0.55 part of p-hydroxyacetophenone into 10-80 parts of deionized water, uniformly stirring, and heating for dissolving to obtain a material body a;
s2, stirring and cooling the material body a obtained in the step S1 to below 40 ℃, sequentially adding 1-20 parts of the long-term anti-wrinkle composition, 1-15 parts of the collagen production promoting composition, 1-10 parts of the algae extract and 0.16-0.165 part of arginine, uniformly stirring, and filtering to obtain the anti-wrinkle eye mask essence.
Drawings
Fig. 1 is a graph of immediate visual effects of using anti-wrinkle eye mask concentrate for 30 min.
FIG. 2 is a graph showing the results of the rate of change of the elasticity R2.
FIG. 3 is a graph of the results of the compactness F4 rate of change test.
Fig. 4 is a graph showing the results of the under-eye wrinkle (coarse area) change rate test.
Fig. 5 is a graph showing the results of the under-eye wrinkle (total area) change rate test.
FIG. 6 is a graph of the results of a fish tail rating scale score change rate test.
FIG. 7 is a chart of the results of the VISIA-CR facial scan test.
FIG. 8 is another result of the VISIA-CR facial scan test.
FIG. 9 is another result of the VISIA-CR facial scan test.
FIG. 10 is a graph showing the results of the fish tail area improvement rate test.
Fig. 11 is a graph showing the results of the cheek skin elasticity improvement rate test.
Fig. 12 is a graph showing the results of the test for the improvement rate of skin elasticity at the corners of eyes.
Fig. 13 is a graph showing the results of the skin friction force change rate test.
FIG. 14 is a graph showing the results of the skin collagen density improvement rate test.
Detailed Description
The present invention provides an anti-wrinkle composition and an anti-wrinkle cosmetic, and the present invention is further described in detail below for the purpose, technical scheme and effect of the present invention to be more clear and definite. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The formulations of the instant long-acting anti-wrinkle compositions and the compositions for promoting collagen production and strengthening the euepidermal junction in examples 1-4 below were:
namely, the long-acting anti-wrinkle composition comprises the following raw materials in parts by weight: 0.304 part of snake venom peptide, 0.016 part of conopeptide, 0.15 part of acetyl tetrapeptide-2, 1 part of L-proline-lactic acid and 1 part of L-proline-glycerol;
the composition for promoting collagen production and strengthening the connection of the dermis is prepared from the following raw materials in parts by weight: 13.2 parts of betaine glycerol, 0.105 part of palmitoyl tripeptide-5, 0.205 part of hexapeptide-9 and 0.2 part of hexapeptide-11.
Example 1
The anti-wrinkle essence is prepared from the following components in parts by weight:
phase A: 0.03 parts EDTA-2Na, 0.5 parts SEPIMAX ZEN, 0.3 parts EMT-10, 3 parts glycerol, 2 parts butanediol, 2 parts glycerol glucoside, 0.03 parts HA (conventional grade), and 0.03 parts HA (nano grade);
and B phase: 8 parts of DOWSIL 9509, 0.5 part of vaseline, 0.2 part of VE and 0.8 part of hydrogenated lecithin S-10;
and C phase: 0.4 parts of phenoxyethanol and 0.5 part of hexanediol;
and D phase: 4 parts of instant long-acting anti-wrinkle composition, 2 parts of composition for promoting collagen generation and strengthening euepidermic connection and 0.1 part of arginine;
the preparation method of the anti-wrinkle essence comprises the following steps:
1. adding the phase A into 75.61 parts of deionized water, uniformly stirring, and heating and dissolving at 80 ℃ to obtain a solution a;
2. putting the phase B into a clean beaker, and heating to be completely dissolved at 80 ℃ to obtain a solution B;
3. adding the solution b obtained in the step 2 into the solution a obtained in the step 1, and homogenizing until emulsification is completed to obtain a solution c;
4. adding the phase C into the solution C obtained in the step 3, and stirring and cooling to obtain a material d;
5. and D, adding the phase D into the material body D obtained in the step 4, and uniformly stirring to obtain the anti-wrinkle essence.
Example 2
The anti-wrinkle essence is prepared from the following components in parts by weight:
phase A: 0.03 parts EDTA-2Na, 0.6 parts SEPIMAX ZEN, 0.35 parts EMT-10, 3 parts glycerol, 2 parts butanediol, 2 parts glycerol glucoside, 0.03 parts HA (conventional grade), and 0.03 parts HA (nano grade);
and B phase: 8 parts of DOWSIL 9509, 0.5 part of vaseline, 0.2 part of VE and 0.8 part of hydrogenated lecithin S-10;
and C phase: 0.4 parts of phenoxyethanol and 0.5 part of hexanediol;
and D phase: 4 parts of instant long-acting anti-wrinkle composition, 2 parts of composition for promoting collagen generation and strengthening euepidermic connection and 0.15 part of arginine;
the preparation method of the anti-wrinkle essence comprises the following steps:
1. adding the phase A into 75.41 parts of deionized water, uniformly stirring, and heating and dissolving at 80 ℃ to obtain a solution a;
2. putting the phase B into a clean beaker, and heating to be completely dissolved at 80 ℃ to obtain a solution B;
3. adding the solution b obtained in the step 2 into the solution a obtained in the step 1, and homogenizing until emulsification is completed to obtain a solution c;
4. adding the phase C into the solution C obtained in the step 3, and stirring and cooling to obtain a material d;
5. and D, adding the phase D into the material body D obtained in the step 4, and uniformly stirring to obtain the anti-wrinkle essence.
Example 3
The anti-wrinkle eye mask essence is prepared from the following components in parts by weight:
phase A: 0.15 part of sclerotium rolfsii, 0.2 part of 250HHR, 3 parts of HZ-1706, 2 parts of jojoba oil, 2 parts of glycerol and 0.5 part of betaine;
and B phase: 3 parts of butanediol, 0.5 part of hexanediol and 0.5 part of p-hydroxyacetophenone;
and C phase: 4 parts of instant long-acting anti-wrinkle composition, 2 parts of composition for promoting collagen production, 3 parts of algae extract and 0.16 part of arginine;
the preparation method of the anti-wrinkle eye mask essence comprises the following steps:
1. adding the phase A and the phase B into 78.99 parts of deionized water, uniformly stirring, and heating and dissolving at 85 ℃ to obtain a material body a;
2. and (3) stirring and cooling the material body a obtained in the step (1) to below 40 ℃, adding the phase C, uniformly stirring, and filtering to obtain the anti-wrinkle eye mask essence.
Example 4
The anti-wrinkle eye mask essence is prepared from the following components in parts by weight:
phase A: 0.15 part of sclerotium rolfsii, 0.2 part of 250HHR, 3 parts of HZ-1706, 2 parts of jojoba oil, 2 parts of glycerol and 0.5 part of betaine;
and B phase: 3 parts of butanediol, 0.5 part of hexanediol and 0.5 part of p-hydroxyacetophenone;
and C phase: 2 parts of instant long-acting anti-wrinkle composition, 2 parts of collagen production promoting composition, 3 parts of algae extract and 0.2 part of arginine;
the preparation method of the anti-wrinkle eye mask essence comprises the following steps:
1. adding the phase A and the phase B into 80.95 parts of deionized water, uniformly stirring, and heating and dissolving at 85 ℃ to obtain a material body a;
2. and (3) stirring and cooling the material body a obtained in the step (1) to below 40 ℃, adding the phase C, uniformly stirring, and filtering to obtain the anti-wrinkle eye mask essence.
Instant and long-lasting anti-wrinkle evaluation was performed on the anti-wrinkle essence of example 1 and the anti-wrinkle eye mask essence of example 2
1. Immediate wrinkle resistance evaluation:
test part: periocular and facial skin.
Test object: 36 volunteers aged 30-60 years were selected for skin health, with fine lines or wrinkles at the canthus reaching grade 3 or more.
Test instrument: CK skin elasticity tester, VISIA-CR face scanner.
The testing method comprises the following steps: subjects 1-18 randomly use anti-wrinkle eye mask essence, 19-36 subjects use anti-wrinkle essence on the whole face, skin data are respectively acquired 30min, 1h and 2h after single sample use and skin data are acquired after continuous 1D use, and normal verification is carried out on elasticity R2, compactness F4, eye tail (length), eye tail (area/quantity) and fish tail grade scores.
The test results are shown in fig. 1-6:
results after 30min single use of the sample:
anti-wrinkle eye mask essence:
the elasticity R2 increases by 1.51%; the eye tail length is significantly improved by 10.85% (P < 0.05); eye tail (area/number) was significantly improved by 16.44% (P < 0.01);
anti-wrinkle essence: the elasticity R2 is increased by 3.50%; the eye tail length is significantly improved by 10.06% (P < 0.01); the eye tail (area/number) was significantly improved by 11.18% (P < 0.05).
Results after 1h of single use of sample:
anti-wrinkle eye mask essence: the elasticity R2 increases by 1.66%; the eye tail length is significantly improved by 9.28% (P < 0.05); eye tail (area/number) was significantly improved by 14.18% (P < 0.01);
anti-wrinkle essence: the elasticity R2 increases by 6.63%; the eye tail length is significantly improved by 10.82% (P < 0.01); the eye tail (area/number) was significantly improved by 12.57% (P < 0.01).
Results after 2h single use of sample:
anti-wrinkle eye mask essence: the eye tail length is significantly improved by 14.67% (P < 001); eye tail (area/number) was significantly improved by 18.12% (P < 0.01);
anti-wrinkle essence: the elasticity R2 increases by 4.74%; the eye tail length is significantly improved by 13.53% (P < 0.001); the eye tail (area/number) was significantly improved by 13.75% (P < 0.01).
Results after single use of sample 1D:
anti-wrinkle eye mask essence:
the elasticity R2 is significantly increased by 8.15% (P < 0.05); the compactness F4 is improved by 9.00%; the eye tail length is significantly improved by 9.90% (P < 0.01); eye tail (area/number) was significantly improved by 11.26% (P < 0001); the score of the fish tail score was significantly improved by 21.05% (P < 0.01);
anti-wrinkle essence: the elasticity R2 increases significantly by 8.04% (P < 0.05); the compactness F4 is significantly improved by 13.06% (P < 0.05); the eye tail length is significantly improved by 11.38% (P < 001); eye tail (area/number) significantly improved 888% (P < 0.05); the fish tail rating score significantly changed by 14.29% (P < 0.01).
The VISIA-CR facial scan test results are shown in FIGS. 7-9:
as shown in fig. 7, the number of wrinkles under the eyes in the same area of the subject was reduced by 23.81%, 42.86%, 47.62%, 57.14% respectively, and the areas of wrinkles under the eyes in the same area of the subject was reduced by 28.96%, 47.08%, 35.71%, 52.31% respectively, when the anti-wrinkle eye mask essence was used for 30min, 1h, 2h, and 1D on the face of the subject.
As shown in fig. 8, the number of wrinkles under the eyes in the same area of the subject was decreased by 40.63%, 25% and 31.25% respectively, and the areas of wrinkles under the eyes in the same area of the subject was decreased by 41.89%, 16.78%, 32.80% and 23.96% respectively, when the anti-wrinkle eye mask essence was used for 30min, 1h, 2h and 1D on the face of the subject.
As shown in fig. 9, the number of wrinkles under the eyes in the same area of the subject is respectively reduced by 20.33%, 56.67%, 26.67% and 33.33% by using anti-wrinkle essence for 30min, 1h, 2h and 1D on the face of the subject; the length of the wrinkles under the eyes of the same area of the subject is respectively reduced by 14.45%, 20.47%, 4.32% and 6.79%; the length of the wrinkles under the eyes of the same area of the subject was reduced by 26.41%, 58%, 20.37% and 32.69%, respectively.
In conclusion, the anti-wrinkle eye mask essence and the anti-wrinkle essence have instant anti-wrinkle and tightening effects.
2. Long-acting anti-wrinkle evaluation:
test part: periocular and facial skin.
Test object: 17 volunteers with healthy skin and ages 30-60 were selected.
Test instrument: an elasticity test probe, a VISIA-CR face scanner, a skin friction test probe and a high-frequency skin ultrasonic measurement probe.
The testing method comprises the following steps: subjects 1-17 were randomly used with anti-wrinkle serum, skin data were collected on days D0, D14, D28 after using the samples, and normalization was verified for elasticity R2, firmness F4, eye tail (length), eye tail (area/number), fish tail rating scores.
1. The fish tail area is obtained by VISIA-CR shooting combined with IPP analysis; the smaller the number, the smaller the fish tail area.
At each access point, the detection result of the fish tail area is shown in fig. 10:
conclusion: compared to the basal value (D0), at the D14 day return visit, fish tail increases by 3.96%; at the D28 return visit, the fish tail area was reduced by 0.39%.
2. Cheek skin elasticity analysis
Skin elasticity was measured by Cutometer dual MPA, 580; the greater the number, the better the skin elasticity.
At each visit point, the detection result of the face elasticity is shown in fig. 11:
conclusion: the cheek skin elasticity improvement rate was increased by 4.27% and 8.8% at D14 days, D28 return visit, respectively, compared to the basal value (D0).
3. Analysis of canthus skin elasticity
Skin elasticity was measured by Cutometer dual MPA, 580; the greater the number, the better the skin elasticity.
At each visit point, the results of the detection of the skin elasticity of the canthus are shown in fig. 12:
conclusion: the improvement in canthus skin elasticity was increased by 7.81% and 12.77% at D14 and D28 return visits, respectively, compared to the basal value (D0).
4. Skin friction analysis
The roughness of the skin is represented by measuring the facial skin friction, which is measured by the Frictiometer FR 700; the smaller the value, the better the skin fineness.
The results of the skin friction detection at each visit point are shown in fig. 13:
conclusion: compared to the basal value (D0), the skin friction increased by 3.16% at the D14 day return visit and decreased by 14.5% at the D28 day return visit.
5. Skin collagen densitometry
Skin collagen density was measured by a high frequency skin ultrasonic measurement probe manufactured by Combo company, denmark; the higher the number, the higher the collagen density.
The results of the skin collagen density detection at each visit point are shown in fig. 14:
conclusion: the skin collagen density was increased by 3.02% and 9.05% at D14, D28 return visit, compared to the basal value (D0).
In conclusion, the anti-wrinkle essence has the effects of long-acting anti-wrinkle and restoring skin elasticity.
It is to be understood that the invention is not limited in its application to the examples described above, but is capable of modification and variation in light of the above teachings by those skilled in the art, and that all such modifications and variations are intended to be included within the scope of the appended claims.
Claims (10)
1. An anti-wrinkle composition is characterized by comprising 1-20 parts by weight of an instant long-term anti-wrinkle composition and 1-15 parts by weight of a composition for promoting collagen production and strengthening euepidermic connection;
the instant long acting anti-wrinkle composition comprises: 0.01-4 parts of snake venom peptide, 0.01-5 parts of conopeptide, 0.01-4.5 parts of acetyl tetrapeptide-2, 0.5-20 parts of L-proline-lactic acid and 0.5-20 parts of L-proline-glycerol;
the composition for promoting collagen production and strengthening the connection of the dermis comprises: 5-20 parts of betaine glycerol, 0.01-6 parts of palmitoyl tripeptide-5, 0.01-1 part of hexapeptide-9 and 0.01-2 parts of hexapeptide-11.
2. The anti-wrinkle composition according to claim 1, wherein the anti-wrinkle composition consists of 1-20 parts of the instant long-lasting anti-wrinkle composition and 1-15 parts of the composition for promoting collagen production and strengthening euepidermal junction;
the instant long-acting anti-wrinkle composition comprises the following raw materials in parts by weight: 0.304 part of snake venom peptide, 0.016 part of conopeptide, 0.15 part of acetyl tetrapeptide-2, 1 part of L-proline-lactic acid and 1 part of L-proline-glycerol;
the composition for promoting collagen production and strengthening the connection of the dermis is prepared from the following raw materials in parts by weight: 13.2 parts of betaine glycerol, 0.105 part of palmitoyl tripeptide-5, 0.205 part of hexapeptide-9 and 0.2 part of hexapeptide-11.
3. An anti-wrinkle cosmetic comprising an anti-wrinkle composition according to any one of claims 1-2 and a cosmetically acceptable adjuvant.
4. The anti-wrinkle cosmetic according to claim 3, wherein the cosmetic comprises one of a skin softening lotion, an essence, an emulsion, a face cream, an eye cream, a facial mask, an eye mask, and a facial cleanser.
5. An anti-wrinkle essence, characterized in that the anti-wrinkle essence comprises the anti-wrinkle composition according to any one of claims 1-2, a humectant, an emollient, a pH adjustor, a thickener, a preservative, a chelating agent, deionized water.
6. The anti-wrinkle essence according to claim 5, wherein the humectant is sodium hyaluronate, glucosyl glycerate, butylene glycol, glycerin, hexylene glycol, hydrogenated lecithin S-10; the emollient is vaseline, VE, DOWSIL 9509; the pH regulator is arginine; the thickener is SEPIMAX ZEN and EMT-10; the preservative is phenoxyethanol; the chelating agent is EDTA-2Na.
7. The anti-wrinkle essence according to claim 5, wherein the anti-wrinkle essence comprises, in parts by weight, 1-20 parts of instant long-lasting anti-wrinkle composition, 1-15 parts of composition for promoting collagen production and strengthening eudermic connection, 0.03-0.035 parts of conventional HA, 0.03-0.035 parts of nano-scale HA, 2-2.05 parts of glyceroglycosides, 2-2.05 parts of butanediol, 3-3.05 parts of glycerol, 0.5-0.55 parts of hexanediol, 0.8-0.85 parts of hydrogenated lecithin S-10, 0.5-0.55 parts of vaseline, 0.2-0.25 parts of VE, 8-8.05 parts of DOWSIL 9509, 0.1-0.15 parts of arginine, 0.5-0.6 parts of SEPIMAX ZEN, 0.3-0.35 parts of EMT-10, 0.4-0.45 parts of phenoxyethanol, 0.03-0.05 parts of Na-2 and 10-80 parts of deionized water.
8. An anti-wrinkle eye mask essence, which comprises the anti-wrinkle composition according to any one of claims 1 to 2, an algae extract, a humectant, a pH regulator, a thickener, an antioxidant and deionized water.
9. The anti-wrinkle eye mask essence according to claim 8, wherein the humectant is HZ1706, jojoba oil, glycerin, betaine, butylene glycol, hexylene glycol; the pH regulator is arginine; the thickener is sclerotium rolfsii, 250HHR; the antioxidant is p-hydroxyacetophenone.
10. The anti-wrinkle eye mask essence according to claim 8, wherein the anti-wrinkle eye mask essence comprises, in parts by weight, 1-20 parts of instant long-lasting anti-wrinkle composition, 1-15 parts of composition for promoting collagen production and strengthening euepidermic junction, 1-10 parts of algae extract, 3-3.05 parts of HZ1706, 2-2.05 parts of luba oil, 2-2.05 parts of glycerin, 0.5-0.55 parts of betaine, 3-3.05 parts of butylene glycol, 0.5-0.55 parts of hexylene glycol, 0.16-0.165 parts of arginine, 0.15-0.16 parts of micronucleus glue, 0.2-0.25 parts of 250HHR, 0.5-0.55 parts of p-hydroxyacetophenone, and 10-80 parts of deionized water.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117297990A (en) * | 2023-11-27 | 2023-12-29 | 深圳杉海创新技术有限公司 | Anti-aging composition and preparation method and application thereof |
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2023
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117297990A (en) * | 2023-11-27 | 2023-12-29 | 深圳杉海创新技术有限公司 | Anti-aging composition and preparation method and application thereof |
| CN117297990B (en) * | 2023-11-27 | 2024-03-19 | 深圳杉海创新技术有限公司 | Anti-aging composition and preparation method and application thereof |
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