CN117797082A - Composition with antipruritic effect and application thereof in preparing repair milk - Google Patents
Composition with antipruritic effect and application thereof in preparing repair milk Download PDFInfo
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- CN117797082A CN117797082A CN202410231587.0A CN202410231587A CN117797082A CN 117797082 A CN117797082 A CN 117797082A CN 202410231587 A CN202410231587 A CN 202410231587A CN 117797082 A CN117797082 A CN 117797082A
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- 239000000203 mixture Substances 0.000 title claims abstract description 66
- 230000001139 anti-pruritic effect Effects 0.000 title claims abstract description 61
- 230000008439 repair process Effects 0.000 title claims abstract description 14
- 235000013336 milk Nutrition 0.000 title abstract description 6
- 239000008267 milk Substances 0.000 title abstract description 6
- 210000004080 milk Anatomy 0.000 title abstract description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 80
- 238000000855 fermentation Methods 0.000 claims abstract description 59
- 230000004151 fermentation Effects 0.000 claims abstract description 59
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 56
- VJVOFLWZDWLHNR-MRCUWXFGSA-N icosan-9-yl (z)-docos-13-enoate Chemical compound CCCCCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCCCC VJVOFLWZDWLHNR-MRCUWXFGSA-N 0.000 claims abstract description 40
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 40
- 229940032094 squalane Drugs 0.000 claims abstract description 40
- 241000193830 Bacillus <bacterium> Species 0.000 claims abstract description 39
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 39
- 244000068988 Glycine max Species 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000003906 humectant Substances 0.000 claims abstract description 36
- 239000008367 deionised water Substances 0.000 claims abstract description 35
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 35
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 28
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 28
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 28
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 28
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract description 28
- 229960000458 allantoin Drugs 0.000 claims abstract description 28
- 229960003237 betaine Drugs 0.000 claims abstract description 28
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 28
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229940101267 panthenol Drugs 0.000 claims abstract description 28
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 28
- 239000011619 pantothenol Substances 0.000 claims abstract description 28
- 239000002562 thickening agent Substances 0.000 claims abstract description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- 241000736131 Sphingomonas Species 0.000 claims description 20
- 239000003908 antipruritic agent Substances 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 13
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 11
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 11
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 7
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 7
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 7
- 229940035437 1,3-propanediol Drugs 0.000 claims description 7
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 7
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 7
- 235000021355 Stearic acid Nutrition 0.000 claims description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- 229940059958 centella asiatica extract Drugs 0.000 claims description 7
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 7
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 7
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 7
- 229940070765 laurate Drugs 0.000 claims description 7
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 7
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 7
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 7
- 229940084032 paeonia lactiflora root extract Drugs 0.000 claims description 7
- -1 polydimethylsiloxane Polymers 0.000 claims description 7
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 7
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 7
- 239000008117 stearic acid Substances 0.000 claims description 7
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 6
- 229940008099 dimethicone Drugs 0.000 claims description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 18
- 208000003251 Pruritus Diseases 0.000 abstract description 14
- 230000007803 itching Effects 0.000 abstract description 10
- 239000002994 raw material Substances 0.000 abstract description 8
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 53
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 102000004890 Interleukin-8 Human genes 0.000 description 2
- 108090001007 Interleukin-8 Proteins 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 2
- 229960002986 dinoprostone Drugs 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 2
- 229940096397 interleukin-8 Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
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- 238000007254 oxidation reaction Methods 0.000 description 2
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004125 Interleukin-1alpha Human genes 0.000 description 1
- 108010082786 Interleukin-1alpha Proteins 0.000 description 1
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- 206010053262 Skin swelling Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 229960004979 fampridine Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 102000009634 interleukin-1 receptor antagonist activity proteins Human genes 0.000 description 1
- 108040001669 interleukin-1 receptor antagonist activity proteins Proteins 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000003098 myoblast Anatomy 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
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- 230000037394 skin elasticity Effects 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
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- 239000008223 sterile water Substances 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and particularly discloses a composition with an antipruritic effect and application thereof in preparing repair milk, wherein the composition comprises the following components in parts by weight: 0.1-0.3 part of thickener, 0.1-0.6 part of panthenol, 0.1-0.6 part of hydrolyzed zinc hyaluronate, 0.2-0.8 part of tocopheryl acetate, 0.3-0.8 part of allantoin, 0.2-1 part of bacillus/soybean fermentation product extract, 0.3-1 part of betaine, 0.5-2 parts of glyceroglyceoside, 1-3 parts of squalane, 8-16 parts of humectant and 70-90 parts of deionized water. According to the invention, the composition with excellent itching relieving and repairing effects is obtained by combining the raw materials according to specific parts by weight, wherein the hydrolyzed zinc hyaluronate, bacillus/soybean fermentation product extract and squalane have remarkable synergistic effects in the aspects of itching relieving and repairing.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a composition with an antipruritic effect and application thereof in preparing repair milk.
Background
With the increasing complexity of living environment and the change of life style of people, the skin itch problem has become a great difficulty which puzzles a plurality of people. Skin itch not only affects the quality of a patient's daily life, but may also cause further skin diseases. Therefore, it is particularly important to develop a safe and effective antipruritic composition.
Traditional antipruritic methods have mostly relied on drugs such as antihistamines, hormonal drugs, etc. Although these drugs can alleviate itching symptoms to some extent, they may cause side effects such as skin atrophy, pigmentation, etc. after long-term use. In addition, these drugs have different effects on itch caused by different reasons, and it is difficult to meet diversified antipruritic demands.
In view of this, the present application is presented.
Disclosure of Invention
The invention provides a composition with an antipruritic effect and application thereof in preparing repairing milk, wherein the composition has excellent antipruritic and repairing effects.
The invention solves the technical problems by adopting the following technical scheme:
a composition with antipruritic effect comprises the following components in parts by weight: 0.1-0.3 part of thickener, 0.1-0.6 part of panthenol, 0.1-0.6 part of hydrolyzed zinc hyaluronate, 0.2-0.8 part of tocopheryl acetate, 0.3-0.8 part of allantoin, 0.2-1 part of bacillus/soybean fermentation product extract, 0.3-1 part of betaine, 0.5-2 parts of glyceroglyceoside, 1-3 parts of squalane, 8-16 parts of humectant and 70-90 parts of deionized water.
Wherein, zinc hyaluronate is purchased from Hua Xi organism, record No.: 20220008 the hydrolyzed zinc hyaluronate HAs the effects of both HA and zinc, HAs the characteristics of moisturizing, repairing and nourishing skin, HAs the effects of resisting oxidation and relieving zinc, can effectively reduce the expression quantity of inflammatory factors IL-8 (interleukin-8) and PGE2 (prostaglandin E2), obviously lower the ratio of IL-1ra/IL-1 alpha, HAs a relieving effect on the skin in question, and effectively inhibits inflammatory reaction and anaphylactic reaction, thereby playing roles of relieving itching and resisting bacteria.
The bacillus/soybean fermentation product extract has an antibacterial effect, can help skin resist invasion of external harmful bacteria, maintain skin health, promote repair and regeneration of skin cells, increase skin elasticity and firmness, have a certain anti-aging effect, promote overall skin quality, enable the skin to be more compact and elastic, and relieve skin swelling and sensitivity. Meanwhile, the skin care product also has the antioxidation effect, can remove free radicals and reduce skin injury caused by ultraviolet irradiation.
The squalane can be integrated with the sebum membrane of human body, forms a natural barrier on the skin surface, can effectively inhibit oxidation of skin lipid, promotes proliferation of myoblasts, and has a certain effect on delaying skin aging. When the skin is dry and itchy, the skin can be relieved, and meanwhile, the squalane can accelerate the repair of epidermis and damaged cells and promote the metabolism of skin cells.
According to the invention, the composition with excellent itching relieving and repairing effects is obtained by combining the raw materials according to specific parts by weight, wherein the hydrolyzed zinc hyaluronate, bacillus/soybean fermentation product extract and squalane have obvious synergistic effects in itching relieving and repairing, and the absence of any one of the raw materials can cause obvious reduction in effect.
As a preferred embodiment of the present invention, the composition comprises the following components in parts by weight: 0.15-0.25 part of thickener, 0.2-0.5 part of panthenol, 0.3-0.5 part of hydrolyzed zinc hyaluronate, 0.4-0.6 part of tocopheryl acetate, 0.4-0.7 part of allantoin, 0.4-0.8 part of bacillus/soybean fermentation product extract, 0.5-0.9 part of betaine, 0.8-1.5 part of glyceroglyceoside, 1.5-2.5 parts of squalane, 10-15 parts of humectant and 80-90 parts of deionized water.
As a preferred embodiment of the present invention, the composition comprises the following components in parts by weight: 0.2 part of thickener, 0.3 part of panthenol, 0.4 part of hydrolyzed zinc hyaluronate, 0.5 part of tocopheryl acetate, 0.5 part of allantoin, 0.6 part of bacillus/soybean fermentation product extract, 0.8 part of betaine, 1 part of glyceroglycoside, 2 parts of squalane, 12 parts of humectant and 81.7 parts of deionized water.
As a preferred embodiment of the present invention, the thickener comprises at least one of xanthan gum, sphingomonas fermentation product extract, hydroxyethyl cellulose, carbomer, polyacrylate crosslinked polymer-6.
As a preferred embodiment of the present invention, the humectant comprises at least one of butylene glycol and glycerin.
As a preferred embodiment of the present invention, the humectant comprises butylene glycol and glycerin in a weight ratio of 1: (0.5-2).
The invention also provides a preparation method of the composition with the antipruritic effect, which comprises the following steps:
adding a thickening agent, a humectant and squalane into deionized water, heating to 75-80 ℃, uniformly stirring, cooling to 35-45 ℃, adding panthenol, hydrolyzed zinc hyaluronate, tocopheryl acetate, allantoin, bacillus/soybean fermentation product extract, betaine and glyceroglycosides, and uniformly stirring to obtain the composition with antipruritic effect.
The invention also provides application of the composition with the antipruritic effect in preparing the repair milk.
The invention also provides repair emulsion which comprises the following components in parts by weight: 0.01-0.1 part of sodium hyaluronate, 0.1-0.4 part of triethanolamine, 0.2-0.8 part of 1, 2-hexanediol, 0.2-0.8 part of dipotassium glycyrrhizinate, 0.4-1.2 part of cetostearyl alcohol, 0.4-1.5 part of centella asiatica extract, 0.5-2 parts of polydimethylsiloxane, 0.8-2 parts of stearic acid, 0.8-2.5 parts of paeonia lactiflora root extract, 0.5-3 parts of cyclopenta-dimethicone, 0.5-3 parts of polyglycerol-10 laurate, 0.5-3 parts of oat extract, 1-5 parts of dipropylene glycol, 2-5 parts of a composition with antipruritic effect, 2-8 parts of 1, 3-propanediol and 70-85 parts of deionized water;
the composition with the antipruritic effect is the composition with the antipruritic effect.
As a preferred embodiment of the present invention, the composition comprises the following components in parts by weight: 0.02-0.08 part of sodium hyaluronate, 0.1-0.3 part of triethanolamine, 0.2-0.6 part of 1, 2-hexanediol, 0.3-0.7 part of dipotassium glycyrrhizinate, 0.5-1 part of cetostearyl alcohol, 0.5-1.2 part of centella asiatica extract, 0.8-1.5 part of polydimethylsiloxane, 1-1.8 part of stearic acid, 1-2 parts of paeonia lactiflora root extract, 1-3 parts of cyclopenta-dimethicone, 1-3 parts of polyglycerol-10 laurate, 1-3 parts of oat extract, 3-4 parts of composition with antipruritic effect, 2-5 parts of dipropylene glycol, 4-8 parts of 1, 3-propanediol and 70-80 parts of deionized water.
As a preferred embodiment of the present invention, the composition comprises the following components in parts by weight: 0.05 part of sodium hyaluronate, 0.2 part of triethanolamine, 0.5 part of 1, 2-hexanediol, 0.5 part of dipotassium glycyrrhizinate, 0.8 part of cetostearyl alcohol, 0.8 part of centella asiatica extract, 1 part of polydimethylsiloxane, 1.2 parts of stearic acid, 1.5 parts of paeonia lactiflora root extract, 2 parts of cyclopentadimethicone, 2 parts of polyglycerol-10 laurate, 2 parts of oat extract, 3.5 parts of a composition with an antipruritic effect, 4 parts of dipropylene glycol, 6 parts of 1, 3-propanediol and 73.95 parts of deionized water.
The invention has the beneficial effects that: according to the invention, the composition with excellent itching relieving and repairing effects is obtained by combining the raw materials according to specific parts by weight, wherein the hydrolyzed zinc hyaluronate, the bacillus/soybean fermentation product extract and squalane have obvious synergistic effects in the aspects of itching relieving and repairing, and the absence of any one of the zinc hyaluronate, the bacillus/soybean fermentation product extract and squalane can cause obvious reduction in effect.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the invention, the technical characteristics described in an open mode comprise a closed technical scheme composed of the listed characteristics and also comprise an open technical scheme comprising the listed characteristics.
In the present invention, the numerical ranges are referred to as continuous, and include the minimum and maximum values of the ranges, and each value between the minimum and maximum values, unless otherwise specified. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range description features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to include any and all subranges subsumed therein.
In the present invention, the specific dispersing and stirring treatment method is not particularly limited.
The raw materials or instruments for the components used in each example and comparative example of the present invention were all commercially available raw materials or instruments unless otherwise specified, and the raw materials for the components used in each parallel experiment were all the same.
Example 1
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 parts of Sphingomonas fermentation product extract, 0.3 parts of panthenol, 0.4 parts of hydrolyzed zinc hyaluronate, 0.5 parts of tocopheryl acetate, 0.5 parts of allantoin, 0.6 parts of bacillus/soybean fermentation product extract, 0.8 parts of betaine, 1 part of glyceroglycoside, 2 parts of squalane, 12 parts of humectant and 81.7 parts of deionized water.
The humectant comprises butanediol and glycerol, wherein the weight ratio of the butanediol to the glycerol is 1:1.
the preparation method of the composition with the antipruritic effect comprises the following steps:
adding Sphingomonas fermentation product extract, humectant and squalane into deionized water, heating to 75deg.C, stirring, cooling to 40deg.C, adding panthenol, hydrolyzed zinc hyaluronate, tocopheryl acetate, allantoin, bacillus/soybean fermentation product extract, betaine and glyceroglycosides, and stirring to obtain antipruritic composition.
Example 2
A composition with antipruritic effect comprises the following components in parts by weight: 0.15 part of Sphingomonas fermentation product extract, 0.5 part of panthenol, 0.3 part of hydrolyzed zinc hyaluronate, 0.6 part of tocopheryl acetate, 0.4 part of allantoin, 0.8 part of bacillus/soybean fermentation product extract, 0.5 part of betaine, 1.5 parts of glyceroglycoside, 1.5 parts of squalane, 15 parts of humectant and 78.75 parts of deionized water.
The humectant comprises butanediol and glycerol, wherein the weight ratio of the butanediol to the glycerol is 1:1.
the preparation method of the composition with the antipruritic effect comprises the following steps:
adding Sphingomonas fermentation product extract, humectant and squalane into deionized water, heating to 75deg.C, stirring, cooling to 40deg.C, adding panthenol, hydrolyzed zinc hyaluronate, tocopheryl acetate, allantoin, bacillus/soybean fermentation product extract, betaine and glyceroglycosides, and stirring to obtain antipruritic composition.
Example 3
A composition with antipruritic effect comprises the following components in parts by weight: 0.25 parts of Sphingomonas fermentation product extract, 0.2 parts of panthenol, 0.5 parts of hydrolyzed zinc hyaluronate, 0.4 parts of tocopheryl acetate, 0.7 parts of allantoin, 0.4 parts of bacillus/soybean fermentation product extract, 0.9 parts of betaine, 0.8 parts of glyceroglycosides, 2.5 parts of squalane, 10 parts of humectant and 83.35 parts of deionized water.
The humectant comprises butanediol and glycerol, wherein the weight ratio of the butanediol to the glycerol is 1:1.
the preparation method of the composition with the antipruritic effect comprises the following steps:
adding Sphingomonas fermentation product extract, humectant and squalane into deionized water, heating to 75deg.C, stirring, cooling to 40deg.C, adding panthenol, hydrolyzed zinc hyaluronate, tocopheryl acetate, allantoin, bacillus/soybean fermentation product extract, betaine and glyceroglycosides, and stirring to obtain antipruritic composition.
Example 4
A composition with antipruritic effect comprises the following components in parts by weight: 0.1 part of Sphingomonas fermentation product extract, 0.6 part of panthenol, 0.1 part of hydrolyzed zinc hyaluronate, 0.8 part of tocopheryl acetate, 0.3 part of allantoin, 1 part of bacillus/soybean fermentation product extract, 0.3 part of betaine, 2 parts of glyceroglycosides, 1 part of squalane, 16 parts of humectant and 70-90 parts of deionized water.
The humectant comprises butanediol and glycerol, wherein the weight ratio of the butanediol to the glycerol is 1:1.
the preparation method of the composition with the antipruritic effect comprises the following steps:
adding Sphingomonas fermentation product extract, humectant and squalane into deionized water, heating to 75deg.C, stirring, cooling to 40deg.C, adding panthenol, hydrolyzed zinc hyaluronate, tocopheryl acetate, allantoin, bacillus/soybean fermentation product extract, betaine and glyceroglycosides, and stirring to obtain antipruritic composition.
Example 5
A composition with antipruritic effect comprises the following components in parts by weight: 0.3 parts of Sphingomonas fermentation product extract, 0.1 part of panthenol, 0.6 part of hydrolyzed zinc hyaluronate, 0.2 part of tocopheryl acetate, 0.8 part of allantoin, 0.2 part of bacillus/soybean fermentation product extract, 1 part of betaine, 0.5 part of glyceroglycoside, 3 parts of squalane, 8 parts of humectant and 70-90 parts of deionized water.
The humectant comprises butanediol and glycerol, wherein the weight ratio of the butanediol to the glycerol is 1:1.
the preparation method of the composition with the antipruritic effect comprises the following steps:
adding Sphingomonas fermentation product extract, humectant and squalane into deionized water, heating to 75deg.C, stirring, cooling to 40deg.C, adding panthenol, hydrolyzed zinc hyaluronate, tocopheryl acetate, allantoin, bacillus/soybean fermentation product extract, betaine and glyceroglycosides, and stirring to obtain antipruritic composition.
Example 6
The repair emulsion comprises the following components in parts by weight: 0.05 part of sodium hyaluronate, 0.2 part of triethanolamine, 0.5 part of 1, 2-hexanediol, 0.5 part of dipotassium glycyrrhizinate, 0.8 part of cetostearyl alcohol, 0.8 part of centella asiatica extract, 1 part of polydimethylsiloxane, 1.2 parts of stearic acid, 1.5 parts of paeonia lactiflora root extract, 2 parts of cyclopentadimethicone, 2 parts of polyglycerol-10 laurate, 2 parts of oat extract, 3.5 parts of a composition with an antipruritic effect, 4 parts of dipropylene glycol, 6 parts of 1, 3-propanediol and 73.95 parts of deionized water.
The composition with antipruritic effect is the composition with antipruritic effect described in example 1.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 does not contain hydrolyzed zinc hyaluronate, and all other things are the same.
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 parts of Sphingomonas fermentation product extract, 0.3 parts of panthenol, 0.5 parts of tocopheryl acetate, 0.5 parts of allantoin, 0.6 parts of bacillus/soybean fermentation product extract, 0.8 parts of betaine, 1 part of glyceroglycosides, 2 parts of squalane, 12 parts of humectant and 82.1 parts of deionized water.
Comparative example 2
Comparative example 2 example 1 differs in that comparative example 2 does not contain bacillus/soybean fermentation product extract, all other things being equal.
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 parts of Sphingomonas fermentation product extract, 0.3 parts of panthenol, 0.4 parts of hydrolyzed zinc hyaluronate, 0.5 parts of tocopheryl acetate, 0.5 parts of allantoin, 0.8 parts of betaine, 1 part of glyceroglycoside, 2 parts of squalane, 12 parts of humectant and 82.3 parts of deionized water.
Comparative example 3
Comparative example 3 example 1 differs in that comparative example 3 does not contain squalane, all other things being equal.
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 parts of Sphingomonas fermentation product extract, 0.3 parts of panthenol, 0.4 parts of hydrolyzed zinc hyaluronate, 0.5 parts of tocopheryl acetate, 0.5 parts of allantoin, 0.6 parts of bacillus/soybean fermentation product extract, 0.8 parts of betaine, 1 part of glyceroglycoside, 12 parts of humectant and 83.7 parts of deionized water.
Comparative example 4
Comparative example 4 example 1 was different in that comparative example 4 did not contain hydrolyzed zinc hyaluronate, and the weight part of bacillus/soybean fermentation product extract was 0.8 part, and the weight part of squalane was 2.2 parts, all other things being equal.
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 parts of Sphingomonas fermentation product extract, 0.3 parts of panthenol, 0.5 parts of tocopheryl acetate, 0.5 parts of allantoin, 0.8 parts of bacillus/soybean fermentation product extract, 0.8 parts of betaine, 1 part of glyceroglycosides, 2.2 parts of squalane, 12 parts of humectant and 81.7 parts of deionized water.
Comparative example 5
Comparative example 5 example 1 was different in that comparative example 5 did not contain bacillus/soybean fermentation product extract, and the weight part of zinc hyaluronate was hydrolyzed to 0.7 part, and the weight part of squalane was 2.3 parts, all other things being equal.
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 part of Sphingomonas fermentation product extract, 0.3 part of panthenol, 0.7 part of hydrolyzed zinc hyaluronate, 0.5 part of tocopheryl acetate, 0.5 part of allantoin, 0.8 part of betaine, 1 part of glyceroglycoside, 2.3 parts of squalane, 12 parts of humectant and 81.7 parts of deionized water.
Comparative example 6
Comparative example 6 example 1 was different in that comparative example 6 did not contain squalane, and the weight part of zinc hyaluronate hydrolysate was 1.4 parts, and the weight part of bacillus/soybean fermentation product extract was 1.6 parts, all other things being equal.
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 parts of Sphingomonas fermentation product extract, 0.3 parts of panthenol, 1.4 parts of hydrolyzed zinc hyaluronate, 0.5 parts of tocopheryl acetate, 0.5 parts of allantoin, 1.6 parts of bacillus/soybean fermentation product extract, 0.8 parts of betaine, 1 part of glyceroglycoside, 12 parts of humectant and 81.7 parts of deionized water.
Comparative example 7
Comparative example 7 differs from example 1 in that the amounts of zinc hyaluronate, bacillus/soybean fermentation product extract, squalane used are not within the scope of the present invention (the total amounts are identical), and all others are the same.
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 parts of Sphingomonas fermentation product extract, 0.3 parts of panthenol, 0.05 parts of hydrolyzed zinc hyaluronate, 0.5 parts of tocopheryl acetate, 0.5 parts of allantoin, 0.1 parts of bacillus/soybean fermentation product extract, 0.8 parts of betaine, 1 part of glyceroglycoside, 2.85 parts of squalane, 12 parts of humectant and 81.7 parts of deionized water.
Comparative example 8
Comparative example 8 differs from example 1 in that the amounts of zinc hyaluronate, bacillus/soybean fermentation product extract, squalane used are not within the scope of the present invention (the total amounts are identical), and all others are the same.
A composition with antipruritic effect comprises the following components in parts by weight: 0.2 parts of Sphingomonas fermentation product extract, 0.3 parts of panthenol, 0.8 parts of hydrolyzed zinc hyaluronate, 0.5 parts of tocopheryl acetate, 0.5 parts of allantoin, 1.5 parts of bacillus/soybean fermentation product extract, 0.8 parts of betaine, 1 part of glyceroglycoside, 0.7 part of squalane, 12 parts of humectant and 81.7 parts of deionized water.
Test case
1. Antipruritic test: 130 common experimental mice are subjected to weight 20+/-2 g, male and female halves, are randomly divided into 13 groups after being subjected to conventional feeding for 7d, 10 mice in each group, and the compositions in each test group are respectively dissolved into liquid with the concentration of 30mg/ml by using sterile water to serve as test liquid.
The back was shaved by Mao Yao to cmX cm, 1mg/kg of 4-aminopyridine was subcutaneously injected at the shaved area while the drug solution was applied to the shaved area, and after 10 minutes, the skin filtrate was prepared and the histamine content therein was examined. The specific results are shown in Table 1.
2. Percutaneous moisture loss test: to verify barrier repair performance of the present invention, the samples prepared in examples and comparative examples were subjected to a moisturizing efficacy test.
Test instrument: corneometer CM 825 (CK electronic GmbH, germany); tewameter TM 300 (CK electronic GmbH, germany).
Test object: volunteers with healthy skin, no history of skin disease and allergy were selected for each test sample. Because of no personal difference among limbs, the device is suitable for being used as a detected part, and the proper area of the antecarpal flexion side area of a volunteer is selected as a test area.
Number of test persons: selecting a basic value of TEWL with a reddening skin water loss value of more than 12g/mg for a face of 20-35 years old 2 h 130 sensitive muscle volunteers, which were equally divided into 13 groups, 10 persons/group, and the compositions prepared in examples and comparative examples were dispensed, respectively.
Test conditions: volunteers were allowed to stand still in an environment with a Relative Humidity (RH) of 50% + -2% or less at room temperature of 25+ -2 ℃ or less, and the examined parts were exposed 10min before measurement, and the hydration degree of the horny layer and the transdermal water loss (recorded as control values) were measured, respectively.
The testing method comprises the following steps: 2mL of the test sample was applied to the test site in the morning and evening every day, and the test sample was massaged to complete absorption, and the percutaneous loss of water from the epidermis was measured 4 weeks after the use of the test sample (recorded as a test value).
TEWL rate of change = [ (after use of sample-before use of sample)/before use of sample ]. Times.100%.
TABLE 1
As can be seen from Table 1, the compositions of the present invention have excellent antipruritic and restorative effects.
Comparative examples 1 to 5 it can be seen that example 1 is the most preferred embodiment of the present invention, having the best antipruritic and repairing effects, controlling the amounts of the raw materials as follows: 0.15-0.25 part of thickener, 0.2-0.5 part of panthenol, 0.3-0.5 part of hydrolyzed zinc hyaluronate, 0.4-0.6 part of tocopheryl acetate, 0.4-0.7 part of allantoin, 0.4-0.8 part of bacillus/soybean fermentation product extract, 0.5-0.9 part of betaine, 0.8-1.5 part of glyceroglyceoside, 1.5-2.5 parts of squalane, 10-15 parts of humectant and 80-90 parts of deionized water, and can further improve itching relieving and repairing effects.
As can be seen from comparative example 1 and comparative examples 1 to 6, the hydrolyzed zinc hyaluronate, bacillus/soybean fermentation product extract, squalane of the present invention have significant synergistic effects in relieving itching and repairing, and the absence of any one of them results in a significant drop in effect.
As can be seen from comparative example 1 and comparative examples 7-8, the antipruritic and repairing effects are further improved by controlling the amounts of zinc hyaluronate, bacillus/soybean fermentation product extract and squalane used.
Finally, it should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will understand that changes can be made to the technical solutions of the invention or equivalents thereof without departing from the spirit and scope of the technical solutions of the invention.
Claims (10)
1. The composition with the antipruritic effect is characterized by comprising the following components in parts by weight: 0.1-0.3 part of thickener, 0.1-0.6 part of panthenol, 0.1-0.6 part of hydrolyzed zinc hyaluronate, 0.2-0.8 part of tocopheryl acetate, 0.3-0.8 part of allantoin, 0.2-1 part of bacillus/soybean fermentation product extract, 0.3-1 part of betaine, 0.5-2 parts of glyceroglyceoside, 1-3 parts of squalane, 8-16 parts of humectant and 70-90 parts of deionized water.
2. The composition with antipruritic effect as claimed in claim 1, which comprises the following components in parts by weight: 0.15-0.25 part of thickener, 0.2-0.5 part of panthenol, 0.3-0.5 part of hydrolyzed zinc hyaluronate, 0.4-0.6 part of tocopheryl acetate, 0.4-0.7 part of allantoin, 0.4-0.8 part of bacillus/soybean fermentation product extract, 0.5-0.9 part of betaine, 0.8-1.5 part of glyceroglyceoside, 1.5-2.5 parts of squalane, 10-15 parts of humectant and 80-90 parts of deionized water.
3. The composition with antipruritic effect as claimed in claim 1, which comprises the following components in parts by weight: 0.2 part of thickener, 0.3 part of panthenol, 0.4 part of hydrolyzed zinc hyaluronate, 0.5 part of tocopheryl acetate, 0.5 part of allantoin, 0.6 part of bacillus/soybean fermentation product extract, 0.8 part of betaine, 1 part of glyceroglycoside, 2 parts of squalane, 12 parts of humectant and 81.7 parts of deionized water.
4. The antipruritic composition of claim 1, wherein the thickener comprises at least one of xanthan gum, sphingomonas fermentation product extract, hydroxyethyl cellulose, carbomer, polyacrylate cross-linked polymer-6.
5. The antipruritic composition of claim 1, wherein the humectant comprises at least one of butylene glycol and glycerin.
6. The method for preparing the composition with antipruritic effect according to any one of claims 1 to 5, characterized by comprising the steps of:
adding a thickening agent, a humectant and squalane into deionized water, heating to 75-80 ℃, uniformly stirring, cooling to 35-45 ℃, adding panthenol, hydrolyzed zinc hyaluronate, tocopheryl acetate, allantoin, bacillus/soybean fermentation product extract, betaine and glyceroglycosides, and uniformly stirring to obtain the composition with antipruritic effect.
7. The use of the composition with antipruritic effect according to any one of claims 1 to 5 for preparing a repair emulsion.
8. The repair emulsion is characterized by comprising the following components in parts by weight: 0.01-0.1 part of sodium hyaluronate, 0.1-0.4 part of triethanolamine, 0.2-0.8 part of 1, 2-hexanediol, 0.2-0.8 part of dipotassium glycyrrhizinate, 0.4-1.2 part of cetostearyl alcohol, 0.4-1.5 part of centella asiatica extract, 0.5-2 parts of polydimethylsiloxane, 0.8-2 parts of stearic acid, 0.8-2.5 parts of paeonia lactiflora root extract, 0.5-3 parts of cyclopenta-dimethicone, 0.5-3 parts of polyglycerol-10 laurate, 0.5-3 parts of oat extract, 1-5 parts of dipropylene glycol, 2-5 parts of a composition with antipruritic effect, 2-8 parts of 1, 3-propanediol and 70-85 parts of deionized water;
the composition with antipruritic effect is the composition with antipruritic effect of any one of claims 1 to 5.
9. The repair emulsion of claim 8, comprising the following components in parts by weight: 0.02-0.08 part of sodium hyaluronate, 0.1-0.3 part of triethanolamine, 0.2-0.6 part of 1, 2-hexanediol, 0.3-0.7 part of dipotassium glycyrrhizinate, 0.5-1 part of cetostearyl alcohol, 0.5-1.2 part of centella asiatica extract, 0.8-1.5 part of polydimethylsiloxane, 1-1.8 part of stearic acid, 1-2 parts of paeonia lactiflora root extract, 1-3 parts of cyclopenta-dimethicone, 1-3 parts of polyglycerol-10 laurate, 1-3 parts of oat extract, 3-4 parts of composition with antipruritic effect, 2-5 parts of dipropylene glycol, 4-8 parts of 1, 3-propanediol and 70-80 parts of deionized water.
10. The repair emulsion of claim 8, comprising the following components in parts by weight: 0.05 part of sodium hyaluronate, 0.2 part of triethanolamine, 0.5 part of 1, 2-hexanediol, 0.5 part of dipotassium glycyrrhizinate, 0.8 part of cetostearyl alcohol, 0.8 part of centella asiatica extract, 1 part of polydimethylsiloxane, 1.2 parts of stearic acid, 1.5 parts of paeonia lactiflora root extract, 2 parts of cyclopentadimethicone, 2 parts of polyglycerol-10 laurate, 2 parts of oat extract, 3.5 parts of a composition with an antipruritic effect, 4 parts of dipropylene glycol, 6 parts of 1, 3-propanediol and 73.95 parts of deionized water.
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