CN113491664A - Composition for quickly relieving pruritus as well as preparation method and application thereof - Google Patents
Composition for quickly relieving pruritus as well as preparation method and application thereof Download PDFInfo
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- CN113491664A CN113491664A CN202110859716.7A CN202110859716A CN113491664A CN 113491664 A CN113491664 A CN 113491664A CN 202110859716 A CN202110859716 A CN 202110859716A CN 113491664 A CN113491664 A CN 113491664A
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Abstract
The invention discloses a composition for rapidly relieving pruritus, a preparation method and application thereof, wherein the composition comprises the following components: glyceryl stearate citrate, tridecyl alcohol stearate, jojoba oil, macadamia nut oil, safflower oil, caprylic/capric triglyceride, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and polydimethylsiloxane; beta-glucan, xanthan gum, silica, arginine, glycerol, dipropylene glycol, a first mixture, a second mixture, water; acrylate/C10-30 alkanol acrylate crosspolymer, polydimethylsiloxane, third blend; olive fruit oil, a fourth mixture, a fifth mixture, a sixth mixture, a seventh mixture, an eighth mixture. The invention also provides a preparation method and application of the composition. The composition prepared by the invention can be used for pertinently solving skin pruritus symptoms caused by different reasons, and promoting skin to strengthen moisturizing, anti-allergy, repairing functions and the like.
Description
Technical Field
The invention relates to a composition for relieving skin itch in the field of cosmetics, a preparation method and application thereof, and particularly relates to a composition for quickly relieving itch, a preparation method and application thereof.
Background
Skin itch, a common symptom of skin, often afflicts various populations. Skin pruritus can occur in all parts of the body, face, back and limbs are the most common, and skin pruritus can be divided into general type and allergic type, wherein the general type of pruritus is generally caused by dry skin, and the allergic type of pruritus is skin pruritus symptom caused by skin allergy. A common skin allergy is actually a hypersensitivity reaction. It refers to the specific immune response mainly caused by the damage of tissue cells when the body is stimulated by certain specific antigens. Skin allergy is more common due to destruction of ecological environment, abuse of various industrial additives in skin care products, and the like. The mechanism of skin itch is a complex pathological process. The epidermis is composed of two types of cells, keratinocytes and dendritic cells, and keratinocytes are the major cells of the epidermis and play a critical role in the onset of skin itch. Keratinocytes can produce a variety of receptors, such as histamine receptors, nerve factor receptors, protease activated receptors, and the like. These receptors may cause symptoms of skin itch, and due to the complexity of the skin itch mechanism, there are currently no specific drugs and effective methods for treating skin itch.
Disclosure of Invention
The invention aims to provide a composition for quickly relieving pruritus, which is suitable for all skin types, and the preparation and the application of the composition in skin care products, can solve the existing problems, aim at the skin pruritus symptoms caused by different reasons, and can promote the skin to strengthen the functions of moisturizing, anti-allergy, repairing and the like.
In order to achieve the above objects, the present invention provides a composition for rapidly relieving itching, wherein the composition comprises a phase a, a phase B, a phase C, a phase D; the phase A comprises glyceryl stearate citrate, tridecyl alcohol stearate, jojoba oil, macadamia nut oil, safflower oil, caprylic/capric triglyceride, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and polydimethylsiloxane; phase B comprises beta-glucan, xanthan gum, silica, arginine, glycerol, dipropylene glycol, a first mixture, a second mixture, and water; the phase C comprises acrylate/C10-30 alkanol acrylate cross-linked polymer, polydimethylsiloxane and a third mixture; the phase D comprises olive fruit oil, a fourth mixture, a fifth mixture, a sixth mixture, a seventh mixture and an eighth mixture.
The composition for rapidly relieving itching is characterized in that the first mixture is obtained by mixing tamarind seed polysaccharide and glucose in any proportion; the second mixture is obtained by mixing sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer according to any proportion; the third mixture is prepared by mixing ceramide 3, ceramide 6II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer, xanthan gum, phenoxyethanol, ethylhexyl glycerol, and water at any ratio; the fourth mixture is obtained by mixing water, 1, 3-propanediol and lactobacillus fermentation lysate according to any proportion; the fifth mixture is obtained by mixing octyl dodecanol and the patchouli leaf extract according to any proportion; the sixth mixture is prepared by mixing water, 1, 2-hexanediol, rhizoma Polygonati Odorati extract, propyl hydroxybenzoate, methyl hydroxybenzoate, p-hydroxyacetophenone, 1, 2-pentanediol, radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, and herba Centellae extract at any ratio; the seventh mixture is prepared by mixing water, butanediol, Artemisia princeps leaf extract, and Fucus vesiculosus extract at any ratio; the eighth mixture is prepared by mixing phenoxyethanol, 1, 3-propylene glycol, propylene carbonate, caprylyl hydroximic acid and o-cymene-5-alcohol according to any proportion.
The composition for rapidly relieving pruritus comprises the following components in parts by weight: 1-3 parts of glycerol stearate citrate, 2-4 parts of tridecyl alcohol stearate, 2-4 parts of jojoba seed oil, 2-4 parts of macadamia nut seed oil, 0.5-1.5 parts of safflower seed oil, 2-3 parts of caprylic/capric triglyceride, 1-3 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2-3 parts of polydimethylsiloxane, 0.4-0.6 part of beta-glucan, 0.2-0.4 part of xanthan gum, 0.4-0.6 part of silica, 0.02-0.08 part of arginine, 1-2 parts of glycerol, 0.4-0.6 part of dipropylene glycol, 0.5-1.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.5-1.5 part of polydimethylsiloxane and 2-4 parts of olive oil.
The composition for rapidly relieving pruritus comprises the following components in percentage by mass: glyceryl stearate citrate 2%, tridecyl alcohol stearate 3%, jojoba oil 3%, macadamia nut oil 3%, safflower seed oil 1%, caprylic/capric triglyceride 2.5%, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 2%, polydimethylsiloxane 2.5%, beta-glucan 0.5%, xanthan gum 0.3%, silica 0.5%, arginine 0.05%, glycerin 1.5%, dipropylene glycol 0.5%, acrylates/C10-30 alkanol acrylate crosspolymer 1%, polydimethylsiloxane 1%, olive oil 3%.
The composition for rapidly relieving pruritus further comprises the following components in parts by weight: 0.5-1.5 parts of a first mixture, 0.5-1.5 parts of a second mixture, 4-6 parts of a third mixture, 4-6 parts of a fourth mixture, 2-4 parts of a fifth mixture, 1-2 parts of a sixth mixture, 0.5-1.5 parts of a seventh mixture and 0.4-0.6 parts of an eighth mixture.
The composition for rapidly relieving pruritus comprises the following components in percentage by mass: first mixture 1%, second mixture 1%, third mixture 5%, fourth mixture 5%, fifth mixture 3%, sixth mixture 1.5%, seventh mixture 1%, eighth mixture 0.5%.
The composition for rapidly relieving pruritus is characterized in that water is added to the composition to 100% by mass percent.
The invention also provides a preparation method of the composition for quickly relieving pruritus, wherein the method comprises the following steps: step 1, weighing raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase; step 2, respectively preheating the phase A and the phase B; step 3, adding phase B into phase A, homogenizing, and then adding phase C, and continuously homogenizing; and 4, cooling and stirring, finally adding the phase D, and continuously stirring until the phase D is uniform.
In the above method for preparing the composition for rapidly relieving itching, in the step 2, the phase a and the phase B are respectively preheated to 80 ℃; in step 3, adding phase B into phase A, homogenizing for 2 minutes, adding phase C, and continuing to homogenize for 2 minutes; and 4, cooling and stirring to 40 ℃, finally adding the phase D, and continuously stirring until the phase D is uniform.
The invention also provides the application of the composition for quickly relieving pruritus prepared by the method, wherein the composition is used for preparing a skin care product; the skin care product comprises body milk.
The composition for quickly relieving pruritus and the preparation method and application thereof provided by the invention have the following advantages:
the composition for quickly relieving the pruritus, disclosed by the invention, combines the ceramide compound, the glucose and the sodium hyaluronate compound, various plant traditional Chinese medicine extracts and the microbial fermentation products for the first time, is suitable for various skin pruritus symptoms, can quickly relieve the skin pruritus and simultaneously can form a natural barrier on the surface of the skin to promote the moisturizing, book locking and bacteriostasis effects of the skin.
The composition has the functions of repairing skin barrier, moisturizing, locking water, resisting inflammation and inhibiting bacteria and the like while achieving the aim of rapidly relieving itching symptoms, so that allergic skin or dry skin is improved, and the skin is kept moist and healthy.
Detailed Description
The following further describes embodiments of the present invention.
The composition for quickly relieving pruritus provided by the invention comprises an A phase, a B phase, a C phase and a D phase; the phase A comprises glyceryl stearate citrate, tridecyl alcohol stearate, jojoba oil, macadamia nut oil, safflower oil, caprylic/capric triglyceride, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and polydimethylsiloxane; phase B comprises beta-glucan, xanthan gum, silica, arginine, glycerol, dipropylene glycol, a first mixture, a second mixture, and water; the phase C comprises acrylate/C10-30 alkanol acrylate cross-linked polymer, polydimethylsiloxane and a third mixture; the phase D comprises olive fruit oil, a fourth mixture, a fifth mixture, a sixth mixture, a seventh mixture and an eighth mixture.
The first mixture is obtained by mixing the sour bean seed polysaccharide and the glucose according to any proportion; the second mixture is obtained by mixing sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer according to any proportion; the third mixture is prepared by mixing ceramide 3, ceramide 6II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer, xanthan gum, phenoxyethanol, ethylhexyl glycerol, and water at any ratio; the fourth mixture is obtained by mixing water, 1, 3-propanediol and lactobacillus fermentation lysate according to any proportion; the fifth mixture is obtained by mixing octyl dodecanol and the patchouli leaf extract according to any proportion; the sixth mixture is prepared by mixing water, 1, 2-hexanediol, rhizoma Polygonati Odorati extract, propyl hydroxybenzoate, methyl hydroxybenzoate, p-hydroxyacetophenone, 1, 2-pentanediol, radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, and herba Centellae extract at any ratio; the seventh mixture is prepared by mixing water, butanediol, Artemisia princeps leaf extract, and Fucus vesiculosus extract at any ratio; the eighth mixture is prepared by mixing phenoxyethanol, 1, 3-propylene glycol, propylene carbonate, caprylyl hydroximic acid and o-cymene-5-alcohol according to any proportion.
Preferably, the composition comprises the following components in parts by weight: 1-3 parts of glycerol stearate citrate, 2-4 parts of tridecyl alcohol stearate, 2-4 parts of jojoba seed oil, 2-4 parts of macadamia nut seed oil, 0.5-1.5 parts of safflower seed oil, 2-3 parts of caprylic/capric triglyceride, 1-3 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2-3 parts of polydimethylsiloxane, 0.4-0.6 part of beta-glucan, 0.2-0.4 part of xanthan gum, 0.4-0.6 part of silica, 0.02-0.08 part of arginine, 1-2 parts of glycerol, 0.4-0.6 part of dipropylene glycol, 0.5-1.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.5-1.5 part of polydimethylsiloxane and 2-4 parts of olive oil.
More preferably, the composition comprises the following components in percentage by mass: glyceryl stearate citrate 2%, tridecyl alcohol stearate 3%, jojoba oil 3%, macadamia nut oil 3%, safflower seed oil 1%, caprylic/capric triglyceride 2.5%, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 2%, polydimethylsiloxane 2.5%, beta-glucan 0.5%, xanthan gum 0.3%, silica 0.5%, arginine 0.05%, glycerin 1.5%, dipropylene glycol 0.5%, acrylates/C10-30 alkanol acrylate crosspolymer 1%, polydimethylsiloxane 1%, olive oil 3%.
Preferably, the composition further comprises the following components in parts by weight: 0.5-1.5 parts of a first mixture, 0.5-1.5 parts of a second mixture, 4-6 parts of a third mixture, 4-6 parts of a fourth mixture, 2-4 parts of a fifth mixture, 1-2 parts of a sixth mixture, 0.5-1.5 parts of a seventh mixture and 0.4-0.6 parts of an eighth mixture.
More preferably, the composition comprises the following components in percentage by mass: first mixture 1%, second mixture 1%, third mixture 5%, fourth mixture 5%, fifth mixture 3%, sixth mixture 1.5%, seventh mixture 1%, eighth mixture 0.5%.
The composition is added with water to 100 percent by mass percent.
The main functional components of the composition of the invention are as follows: ceramide 3, ceramide 6II, ceramide 1, lactobacillus fermentation lysate, beta-glucan, tamarind seed polysaccharide (TAMARINDUS INDICA), glucose, sodium hyaluronate cross-linked polymer, acetylated sodium hyaluronate, hydrolyzed sodium hyaluronate, root extract of Salvia MILTIORRHIZA (Salvia Miltiorrhiza), flower bud extract of clove (Eugenia CARYOPHYLLUS), extract of Fucus VESICULOSUS (Fucus vesiculosis), root extract of Scutellaria BAICALENSIS (Scutellaria BAICALENSIS), root extract of Angelica SINENSIS (Angelica POLYMORPHA SINENSIS), root extract of Glycyrrhiza URALENSIS (Glycyrrhiza URALENSIS), centella asiatica (CENTELLA ASIATICA), leaf extract of Pogostemon cablin, etc.
The patchouli extract can block pain receptor TRPV1 in time, relieve pruritus and red swelling, start cannabinoid receptor system, calm and relieve allergy.
Ceramide is one of the major components of the skin barrier, is a major intercellular lipid, and accounts for more than 50% of intercellular lipids. If ceramide is absent, the skin barrier is damaged, and tissues are absent, so that pruritus and allergy are caused. The bionic skin natural barrier can be formed by adopting various ceramide compounds, the protective barrier function of the skin can be effectively recovered, ceramide is supplied to the skin, the skin barrier is consolidated and repaired, the stimulation of external substances to skin cells is favorably resisted, the invasion of pathogenic microorganisms can be resisted, and meanwhile, the ceramide compound is also a natural moisturizing component, so that the loss of water can be effectively reduced.
The tamarind seed polysaccharide is a natural humectant, is a plurality of polysaccharides extracted from tamarind seeds, contains a large amount of network water-locking molecular tamarind seed polysaccharide, can regulate skin, and has moisturizing, antibacterial and anti-inflammatory effects.
Beta-glucan is derived from Agaricus blazei, and has specific effects of promoting cell growth, wound healing, and enhancing immune system, compared with glucan derived from yeast and plants. It is a multifunctional component with anti-inflammatory, anti-aging, moisture-keeping and after-sun repairing functions, and can resist the stimulation of harmful substances in the air to the skin.
Sodium hyaluronate is an inherent component of the dermis layer of human skin, and has the functions of lubricating and nourishing cells and cell organs. The sodium hyaluronate compound has good viscoelasticity and moisture retention, and can form a moisture-retention breathable film on the surface of skin, so that the stimulation of external substances to the skin is blocked, and the invasion of pathogenic microorganisms is reduced; meanwhile, the skin care product can enter a dermis layer to promote blood circulation and promote absorption and utilization of nutrients by the skin. Therefore, the sodium hyaluronate can further protect the skin and effectively prevent skin allergy while effectively relieving itching symptoms.
The root extract of Salvia MILTIORRHIZA (Salvia MILTIORRHIZA) has fat-soluble and water-soluble components, tanshinone in the fat-soluble component has antiinflammatory and antibacterial effects, and water-soluble components of tanshinol and protocatechuic aldehyde have antioxidant, antibacterial and antiinflammatory effects. The Salvia miltiorrhiza root extract has the effects of inhibiting the proliferation of sebaceous gland cells, reducing the volume of the sebaceous gland cells and relieving the condition of excessive secretion of grease, and is mainly used for anti-allergic and anti-acne products.
Flos Caryophylli (Eugenia CARYOPHYLLUS) bud extract is a non-hormone antiallergic agent, and can reduce skin capillary permeability, inhibit inflammatory reaction, and effectively inhibit hypersensitivity; can enhance skin immunity and promote skin microcirculation. Can effectively improve neurodermatitis and relieve skin pruritus.
The Fucus vesiculosus extract contains unique glutamic acid, and has strong moisture-keeping effect. The Fucus vesiculosus extract also contains alginic acid and calcium alginate, and has effects of improving immunity of skin system, and eliminating and inhibiting harmful substances in skin, thereby achieving anti-inflammatory and anti-allergy effects.
Baicalin and baicalein in radix Scutellariae extract can affect arachidonic acid metabolism channel, inhibit specificity of cytokine, etc. and has antipyretic, antiinflammatory and antiallergic effects; it also has strong antimicrobial effect and broad-spectrum antibacterial effect. Therefore, the skin anti-allergy capability can be enhanced while the pruritus symptom is relieved at a high speed.
The radix Angelicae sinensis extract has effects of promoting blood circulation, removing blood stasis, and improving skin microcirculation; and the SOD has good SOD-like activity, inhibits peroxidation and free radical reaction, is combined with phospholipid to protect a biological membrane, can promote the proliferation of stem cells, and has strong repairing and anti-aging capabilities.
The Glycyrrhrizae radix extract can promote proliferation of muscle cell and vascular endothelial cell, promote collagen production, inhibit NO production, inhibit bacteria, resist inflammation, and promote skin activity.
Centella asiatica extract has the functions of relieving swelling, detoxifying and removing pus.
The patchouli leaf extract can activate CB2 receptors of the skin, inhibit temperature pain receptors TRPV1 and has the function of quickly desensitizing. The patchouli leaf extract can promote the synthesis of beta-endorphin, thereby regulating discomfort such as pruritus, swelling and pain and the like. The patchouli leaf extract also maintains skin barrier homeostasis by promoting the expression of loricrin and collagen I.
The artemisia princeps (ARTEMISIA PRINCEPS) leaf extract contains 4 cytotoxic active ingredients firstly, and inhibits various inflammatory mediators such as: expression of iNOS, IL-1. beta., IL-6, IL-31 and IL-33 was demonstrated in human tumor cell lines cultured against 5 species: a549, SK-OV-3, SK-MEI-2, XF498 and HCT-15 can relieve skin irritation, and thus has anti-allergic and anti-irritation effects and effect of inhibiting atopic dermatitis. Meanwhile, the composition can effectively inhibit beta-hexosaminidase, thereby inhibiting the release of histamine and inflammatory factors and quickly relieving pruritus.
Jojoba (Simmondsia CHINENSIS) seed oil is rich in vitamin A, B, E and minerals such as calcium and magnesium, and has effects in promoting absorption and maintenance of nutrients by skin, and repairing damaged cells. Meanwhile, the skin care product can smooth capillary pores, regulate the oil secretion of the skin, and improve the problems of skin such as pruritus, inflammation, eczema and the like. It has excellent curative effect and relaxing effect on allergic skin.
The nutrients in the seed oil of the macadimia nut (MACADAMIA TERNIFOLIA) are necessary for forming a grease protective layer on the skin, and the oil is mild and does not irritate the skin; macadamia nut oil can also be added in the invention to increase the lubrication degree and the nourishing degree; can promote the establishment of skin barrier, and has the functions of protecting, moistening and moistening skin.
The lactobacillus fermentation lysate is fermented by lactobacillus pentosus, has the effects of softening cutin, preserving moisture and locking water, and is helpful for promoting cell metabolism and simultaneously adjusting pH, thereby preventing the skin from being invaded by pathogenic microorganisms.
The invention also provides a preparation method of the composition for quickly relieving pruritus, which comprises the following steps: step 1, weighing raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase; step 2, respectively preheating the phase A and the phase B; step 3, adding phase B into phase A, homogenizing, and then adding phase C, and continuously homogenizing; and 4, cooling and stirring, finally adding the phase D, and continuously stirring until the phase D is uniform.
In the step 2, respectively preheating the phase A and the phase B to 80 ℃; in step 3, adding phase B into phase A, homogenizing for 2 minutes, adding phase C, and continuing to homogenize for 2 minutes; and 4, cooling and stirring to 40 ℃, finally adding the phase D, and continuously stirring until the phase D is uniform.
The invention also provides the use of the composition for rapidly relieving pruritus prepared by the method, and the composition is used for preparing skin care products; the skin care product comprises body milk.
The composition for rapidly relieving itching, the preparation method and the use thereof provided by the present invention will be further described with reference to the following examples.
Example 1
A composition for rapidly relieving itching comprises the following components shown in Table 1. All the raw materials respectively accord with the corresponding national standards.
Table 1 composition formulation table (in mass percent).
The present embodiment also provides a method for preparing the composition for rapidly relieving itching, comprising:
step 1, weighing the raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase.
And 2, preheating the phase A and the phase B to 80 ℃ respectively.
And 3, adding the phase B into the phase A, homogenizing for 2 minutes, adding the phase C, and continuing to homogenize for 2 minutes.
And 4, cooling and stirring the mixture for 40 ℃, finally adding the phase D, and continuously stirring the mixture until the mixture is uniform.
The embodiment also provides the application of the composition for rapidly relieving pruritus prepared by the method, and the composition is used for preparing skin care products; the skin care product comprises body milk.
Example 2
A composition for rapidly relieving pruritus comprises the following components in parts by weight:
1 part of glycerol stearate citrate, 2 parts of tridecyl alcohol stearate, 2 parts of jojoba seed oil, 2 parts of macadamia nut seed oil, 0.5 part of safflower seed oil, 2 parts of caprylic/capric triglyceride, 1 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2 parts of polydimethylsiloxane, 0.4 part of beta-glucan, 0.2 part of xanthan gum, 0.4 part of silica, 0.02 part of arginine, 1 part of glycerol, 0.4 part of dipropylene glycol, 0.5 part of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.5 part of polydimethylsiloxane and 2 parts of olive oil.
The composition further comprises: 0.5 part of first mixture, 0.5 part of second mixture, 4 parts of third mixture, 4 parts of fourth mixture, 2 parts of fifth mixture, 1 part of sixth mixture, 0.5 part of seventh mixture and 0.4 part of eighth mixture.
Then the composition is added with water to 100 percent by mass percent.
The first mixture is obtained by mixing the sour bean seed polysaccharide and the glucose according to any proportion; the second mixture is obtained by mixing sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer according to any proportion; the third mixture is prepared by mixing ceramide 3, ceramide 6II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer, xanthan gum, phenoxyethanol, ethylhexyl glycerol, and water at any ratio; the fourth mixture is obtained by mixing water, 1, 3-propanediol and lactobacillus fermentation lysate according to any proportion; the fifth mixture is obtained by mixing octyl dodecanol and the patchouli leaf extract according to any proportion; the sixth mixture is prepared by mixing water, 1, 2-hexanediol, rhizoma Polygonati Odorati extract, propyl hydroxybenzoate, methyl hydroxybenzoate, p-hydroxyacetophenone, 1, 2-pentanediol, radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, and herba Centellae extract at any ratio; the seventh mixture is prepared by mixing water, butanediol, Artemisia princeps leaf extract, and Fucus vesiculosus extract at any ratio; the eighth mixture is prepared by mixing phenoxyethanol, 1, 3-propylene glycol, propylene carbonate, caprylyl hydroximic acid and o-cymene-5-alcohol according to any proportion.
The present embodiment also provides a method for preparing the composition for rapidly relieving itching, comprising:
step 1, weighing the raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase.
And 2, preheating the phase A and the phase B to 80 ℃ respectively.
And 3, adding the phase B into the phase A, homogenizing for 2 minutes, adding the phase C, and continuing to homogenize for 2 minutes.
And 4, cooling and stirring the mixture for 40 ℃, finally adding the phase D, and continuously stirring the mixture until the mixture is uniform.
The embodiment also provides the application of the composition for rapidly relieving pruritus prepared by the method, and the composition is used for preparing skin care products; the skin care product comprises body milk.
Example 3
A composition for rapidly relieving pruritus comprises the following components in parts by weight:
3 parts of glycerol stearate citrate, 4 parts of tridecyl alcohol stearate, 4 parts of jojoba seed oil, 4 parts of macadamia nut seed oil, 1.5 parts of safflower seed oil, 3 parts of caprylic/capric triglyceride, 3 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 3 parts of polydimethylsiloxane, 0.6 part of beta-glucan, 0.4 part of xanthan gum, 0.6 part of silica, 0.08 part of arginine, 2 parts of glycerol, 0.6 part of dipropylene glycol, 1.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1.5 parts of polydimethylsiloxane and 4 parts of olive oil.
The composition further comprises: 1.5 parts of first mixture, 1.5 parts of second mixture, 6 parts of third mixture, 6 parts of fourth mixture, 4 parts of fifth mixture, 2 parts of sixth mixture, 1.5 parts of seventh mixture and 0.6 part of eighth mixture.
Then the composition is added with water to 100 percent by mass percent.
The first mixture is obtained by mixing the sour bean seed polysaccharide and the glucose according to any proportion; the second mixture is obtained by mixing sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer according to any proportion; the third mixture is prepared by mixing ceramide 3, ceramide 6II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer, xanthan gum, phenoxyethanol, ethylhexyl glycerol, and water at any ratio; the fourth mixture is obtained by mixing water, 1, 3-propanediol and lactobacillus fermentation lysate according to any proportion; the fifth mixture is obtained by mixing octyl dodecanol and the patchouli leaf extract according to any proportion; the sixth mixture is prepared by mixing water, 1, 2-hexanediol, rhizoma Polygonati Odorati extract, propyl hydroxybenzoate, methyl hydroxybenzoate, p-hydroxyacetophenone, 1, 2-pentanediol, radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, and herba Centellae extract at any ratio; the seventh mixture is prepared by mixing water, butanediol, Artemisia princeps leaf extract, and Fucus vesiculosus extract at any ratio; the eighth mixture is prepared by mixing phenoxyethanol, 1, 3-propylene glycol, propylene carbonate, caprylyl hydroximic acid and o-cymene-5-alcohol according to any proportion.
The present embodiment also provides a method for preparing the composition for rapidly relieving itching, comprising:
step 1, weighing the raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase.
And 2, preheating the phase A and the phase B to 80 ℃ respectively.
And 3, adding the phase B into the phase A, homogenizing for 2 minutes, adding the phase C, and continuing to homogenize for 2 minutes.
And 4, cooling and stirring the mixture for 40 ℃, finally adding the phase D, and continuously stirring the mixture until the mixture is uniform.
The embodiment also provides the application of the composition for rapidly relieving pruritus prepared by the method, and the composition is used for preparing skin care products; the skin care product comprises body milk.
The compositions prepared in the examples were tested and evaluated in the following manner.
1. Test object
Experimental group (invention): 50, 25 men and 25 women; age 16-63 years;
control group (placebo-general moisturizer): 50 cases, 25 men and 25 women, the age is 15-65 years old.
The data of sex, age, etc. of two groups of people are statistically processed, the difference is not statistically significant (P >0.05), and the two groups are comparable.
2. The treatment mode is that the itching part of the experimental group is coated with the traditional moisturizing lotion, the itching part of the control group is coated with the traditional moisturizing lotion, the effect is 1 hour, the following evaluation is carried out, and the occurrence of uncomfortable response is recorded.
3. Evaluation criteria:
evaluation was made on the basis of skin breakdown, redness, stinging and itching.
And (3) healing: the symptoms and signs are resolved by more than 95%.
The effect is shown: the clinical manifestation is reduced by 80 to 94 percent.
Improvement: clinical performance is reduced by 50-79%.
And (4) invalidation: no improvement in clinical manifestations.
4. As a result: the results of treatment for two groups of patients with seborrheic dermatitis are shown in table 2 below.
Table 2 table of test results.
The difference analysis (P is 0.074 and less than 0.05) performed on the experimental group and the control group has significant difference, and has statistical significance. The effective rate of the experimental group is obviously higher than that of the control group, which shows that the experimental group can rapidly relieve the pruritus symptom, and simultaneously, the experimental group does not generate discomfort, thus showing that the invention has super-strong effect.
In the components adopted by the invention, the ceramide compound can form a bionic skin natural barrier, restore the protective barrier function of the skin, consolidate and repair the skin barrier, resist the stimulation of external substances to skin cells, resist the invasion of pathogenic microorganisms and effectively reduce the loss of water. The patchouli leaf extract can activate CB2 receptors of skin and inhibit temperature pain receptors TRPV1, and has the effect of quickly desensitizing. The patchouli leaf extract can synthesize beta-endorphin and regulate uncomfortable feelings such as pruritus, swelling and pain and the like. The patchouli leaf extract promotes the expression of paphiopedilum protein and collagen I and maintains the skin barrier steady state. Beta-glucan can promote cell growth, wound healing and enhance the immune system. The sodium hyaluronate can form a moisturizing breathable film, can block the stimulation of external substances to the skin, reduce the invasion of pathogenic microorganisms, promote blood circulation, effectively relieve itching symptoms, further protect the skin and effectively prevent skin allergy. The lactobacillus fermentation lysate can soften cutin, preserve moisture and lock water, promote cell metabolism, regulate pH value and prevent pathogenic microorganism from invading skin.
The composition for rapidly relieving pruritus, the preparation method and the application thereof provided by the invention have the functions of repairing skin barriers, moisturizing, locking water, resisting inflammation, inhibiting bacteria and the like while achieving the purpose of rapidly relieving pruritus symptoms, so that allergic skin or dry skin is improved, and the skin is kept moist and healthy.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.
Claims (10)
1. A composition for rapidly relieving itching, which comprises a phase A, a phase B, a phase C and a phase D;
the phase A comprises glyceryl stearate citrate, tridecyl alcohol stearate, jojoba oil, macadamia nut oil, safflower oil, caprylic/capric triglyceride, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and polydimethylsiloxane;
phase B comprises beta-glucan, xanthan gum, silica, arginine, glycerol, dipropylene glycol, a first mixture, a second mixture, and water;
the phase C comprises acrylate/C10-30 alkanol acrylate cross-linked polymer, polydimethylsiloxane and a third mixture;
the phase D comprises olive fruit oil, a fourth mixture, a fifth mixture, a sixth mixture, a seventh mixture and an eighth mixture.
2. The composition for rapidly relieving itching according to claim 1, wherein said first mixture is obtained by mixing tamarind seed polysaccharide and glucose in an arbitrary ratio;
the second mixture is obtained by mixing sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer according to any proportion;
the third mixture is prepared by mixing ceramide 3, ceramide 6II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer, xanthan gum, phenoxyethanol, ethylhexyl glycerol, and water at any ratio;
the fourth mixture is obtained by mixing water, 1, 3-propanediol and lactobacillus fermentation lysate according to any proportion;
the fifth mixture is obtained by mixing octyl dodecanol and the patchouli leaf extract according to any proportion;
the sixth mixture is prepared by mixing water, 1, 2-hexanediol, rhizoma Polygonati Odorati extract, propyl hydroxybenzoate, methyl hydroxybenzoate, p-hydroxyacetophenone, 1, 2-pentanediol, radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, and herba Centellae extract at any ratio;
the seventh mixture is prepared by mixing water, butanediol, Artemisia princeps leaf extract, and Fucus vesiculosus extract at any ratio;
the eighth mixture is prepared by mixing phenoxyethanol, 1, 3-propylene glycol, propylene carbonate, caprylyl hydroximic acid and o-cymene-5-alcohol according to any proportion.
3. The composition for rapidly relieving itching according to claim 1, wherein said composition comprises, in parts by weight: 1-3 parts of glycerol stearate citrate, 2-4 parts of tridecyl alcohol stearate, 2-4 parts of jojoba seed oil, 2-4 parts of macadamia nut seed oil, 0.5-1.5 parts of safflower seed oil, 2-3 parts of caprylic/capric triglyceride, 1-3 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2-3 parts of polydimethylsiloxane, 0.4-0.6 part of beta-glucan, 0.2-0.4 part of xanthan gum, 0.4-0.6 part of silica, 0.02-0.08 part of arginine, 1-2 parts of glycerol, 0.4-0.6 part of dipropylene glycol, 0.5-1.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.5-1.5 part of polydimethylsiloxane and 2-4 parts of olive oil.
4. The composition for rapidly relieving itching according to claim 3, wherein said composition comprises, in mass percent: glyceryl stearate citrate 2%, tridecyl alcohol stearate 3%, jojoba oil 3%, macadamia nut oil 3%, safflower seed oil 1%, caprylic/capric triglyceride 2.5%, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 2%, polydimethylsiloxane 2.5%, beta-glucan 0.5%, xanthan gum 0.3%, silica 0.5%, arginine 0.05%, glycerin 1.5%, dipropylene glycol 0.5%, acrylates/C10-30 alkanol acrylate crosspolymer 1%, polydimethylsiloxane 1%, olive oil 3%.
5. The composition for rapidly relieving itching according to claim 3, further comprising in parts by weight: 0.5-1.5 parts of a first mixture, 0.5-1.5 parts of a second mixture, 4-6 parts of a third mixture, 4-6 parts of a fourth mixture, 2-4 parts of a fifth mixture, 1-2 parts of a sixth mixture, 0.5-1.5 parts of a seventh mixture and 0.4-0.6 parts of an eighth mixture.
6. The composition for rapidly relieving itching according to claim 5, wherein said composition comprises, in mass percent: first mixture 1%, second mixture 1%, third mixture 5%, fourth mixture 5%, fifth mixture 3%, sixth mixture 1.5%, seventh mixture 1%, eighth mixture 0.5%.
7. The composition for rapidly relieving itching according to claim 6, wherein water is added to the composition to 100% by mass.
8. A method for preparing a composition for rapidly relieving itching according to any of claims 1 to 7, characterized in that said method comprises:
step 1, weighing raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase;
step 2, respectively preheating the phase A and the phase B;
step 3, adding phase B into phase A, homogenizing, and then adding phase C, and continuously homogenizing;
and 4, cooling and stirring, finally adding the phase D, and continuously stirring until the phase D is uniform.
9. The method for preparing a composition for rapidly relieving itching according to claim 8, wherein in the step 2, the phase A and the phase B are preheated to 80 ℃ respectively; in step 3, adding phase B into phase A, homogenizing for 2 minutes, adding phase C, and continuing to homogenize for 2 minutes; and 4, cooling and stirring to 40 ℃, finally adding the phase D, and continuously stirring until the phase D is uniform.
10. Use of a composition for rapid relief of itch, prepared by the method of claim 8, for the preparation of a skin care product; the skin care product comprises body milk.
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| CN114224952A (en) * | 2021-11-09 | 2022-03-25 | 安徽亿人安股份有限公司 | Traditional Chinese medicine decontamination preparation for soothing skin of infants and preparation method thereof |
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Application publication date: 20211012 |