CN109498523B

CN109498523B - Anti-chapping skin care product and preparation thereof

Info

Publication number: CN109498523B
Application number: CN201811596540.5A
Authority: CN
Inventors: 林东权; 张华强; 张忠伟; 覃奇芳; 陈佳田; 江秋鸿; 黄鹏; 张和平
Original assignee: Guangdong Jungat Daily Chemical Co ltd
Current assignee: Guangdong Jungat Daily Chemical Co ltd
Priority date: 2018-12-25
Filing date: 2018-12-25
Publication date: 2021-07-30
Anticipated expiration: 2038-12-25
Also published as: CN109498523A

Abstract

The invention relates to an anti-chapping skin care product and a preparation method thereof, wherein the anti-chapping skin care product mainly comprises the following components in percentage by weight: 1.0-5.0% of bletilla striata stem extract, 1-20.0% of grease, 0.1-20.0% of phytosterol isostearate, 1-5.0% of ribes nigrum fruit extract, 0.5-3% of hydrolyzed hazelnut protein, 0.5-2% of sodium palmitoyl prolinate, 0.5-2% of nymphaea alba extract, 0.01-10.0% of emulsion thickening agent, 0.5-20.0% of polyalcohol humectant, 0.1-5.0% of urea, 0.1-2.0% of essence, 0.01-0.1% of chelating agent, 0.01-2.0% of neutralizer, 0.01-2.0% of preservative and water added to 100%. According to the invention, the mutual synergistic effect of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the palmitoyl prolinate sodium and the nymphaea alba extract is utilized, the components and the content thereof are reasonably selected, the dry skin, the crack condition and the itching and pain caused by chapping can be improved, the skin rhagadia preventing effect is good, the skin is kept in a moist state, and the whitening cream is not greasy in use and has better skin feeling.

Description

Anti-chapping skin care product and preparation thereof

Technical Field

The invention relates to the field of personal skin care products, in particular to an anti-chapping skin care product and a preparation method thereof.

Background

Human skin is composed of epidermis, dermis and subcutaneous adipose tissue, and the epidermis includes stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum and stratum basale. Each layer of skin contains moisture, with more or less moisture being critical to how tender, plump, shiny and soft the skin is. In autumn and winter, the climate is cold and dry, sweat secretion is less, sebum moistening is lacking, the skin is dry, and various mechanical and physical frictions and contact of detergents, dirt and the like are added, so that wind, dryness and dampness are accumulated on the skin, and a series of chapping symptoms such as skin thickening, dryness, pruritus, crack, bleeding, pain and the like appear. Chap symptoms are common to workers, farmers and household women. At present, ointment containing vaseline and lanolin is generally adopted for treating chaps, and the chaps are slowly self-healed by utilizing the function of lipid to keep moisture, but the products have poor effect and are easy to repeat.

Disclosure of Invention

In view of the problems in the prior art, the present invention aims to provide an anti-chapping skin care product and a preparation method thereof.

A skin care product for preventing chapping comprises 1.0-5.0% of a bletilla striata stem extract, 1-20.0% of grease, 0.1-20.0% of phytosterol isostearate, 1-5.0% of a ribes nigrum fruit extract, 0.5-3% of hydrolyzed hazelnut protein, 0.5-2% of palmitoyl sodium prolinate and 0.5-2% of a nymphaea alba extract.

Further, the paint mainly comprises the following components in percentage by weight:

further, the mass ratio of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea candida presl extract is 10: 6: 1: 1: 1.

furthermore, the mass percentage content of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract is 5.0%, 3.0%, 0.5% and 0.5% respectively.

Further, the extraction method of the bletilla striata stem extract mainly comprises the following steps:

(1) pulverizing rhizoma Bletillae tuber, drying, and sieving to obtain rhizoma Bletillae stem powder; weighing dry powder of bletilla striata stems, performing reflux extraction by using ethanol water solution with the volume concentration of 70-90%, filtering, and collecting filtrate, namely bletilla striata alcohol extract;

(2) adding polyamide and distilled water into the bletilla striata alcohol extract obtained in the step (1), uniformly mixing, and then carrying out reduced pressure evaporation until no alcohol smell exists, so as to obtain a polyamide suspension adsorbing the bletilla striata alcohol extract;

(3) adding the polyamide suspended by distilled water into a chromatographic column, and after settling, filling the polyamide suspension absorbing the bletilla striata alcohol extract in the step 2) into the column;

(4) sequentially eluting with distilled water, 15-25% ethanol water solution with volume concentration and 35-45% ethanol water solution with volume concentration at the flow rate of 2ml/min, and collecting the eluent of the 35-45% ethanol water solution with volume concentration;

(5) adding distilled water into the ethanol eluent collected in the step (4), uniformly mixing, and performing dynamic adsorption by adopting a D101 macroporous resin column at the flow rate of 2 ml/min;

(6) sequentially eluting with 15-25% ethanol water solution and 35-45% ethanol water solution at the flow rate of 2ml/min, collecting 35-45% ethanol eluate, and evaporating under reduced pressure to obtain rhizoma bletilla crude extract;

(7) and (3) uniformly stirring the crude extract of the bletilla striata stems in the step (6) by using a butanediol aqueous solution with the volume concentration of 15-80%, standing at a low temperature for 48h, and filtering to remove insoluble substances to obtain the bletilla striata stem extract.

The obtained rhizoma bletilla stem extract mainly contains water, butanediol, mannan, and glucose; wherein, the weight percentage of the mannan and the glucose in the bletilla striata stem extract is 1 to 10 percent. Refractive index: 1.310-1.390, density: 1.00-1.05g/cm³。

Further, the pH value is 5.0-7.0.

Further, the skin care product comprises skin care emulsion, skin care cream, toning lotion and skin care essence.

Further, the thickening emulsifier is hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

The preparation of the anti-chapping skin care product mainly comprises the following steps:

(1) weighing the components in proportion, putting the oil and the phytosterol isostearic acid into a proper container, heating to 80-85 ℃, and stirring until the oil and the phytosterol isostearic acid are completely dissolved to form an oil phase;

(2) adding water, polyalcohol humectant, emulsifying thickener, urea and chelating agent into a proper container, heating to 80-85 deg.C, stirring to dissolve completely to obtain water phase;

(3) starting a stirring speed of 20r/min, slowly adding the oil phase heated in the step (1) into the water phase heated in the step (2), stirring at a speed of 40r/min, starting a homogenizer, and homogenizing for 3min at a rotating speed of 3000 r/min;

(4) stirring, slowly cooling to 70-60 ℃, and adding a neutralizer;

(5) stirring and cooling to 45 deg.C, adding antiseptic, essence and rhizoma Bletillae stem extract, Ribes nigrum fruit extract, hydrolyzed hazelnut protein, acyl sodium proline, and flos Nymphaeae alba extract, cooling to room temperature, and adjusting pH.

Bletilla striata is a perennial herb of the orchid plant Bletilla striata (Thunb.) reiehb.f. which has been sourced and far-flowing in China historically, and is a cosmetic good drug, namely Bletilla striata, rhizoma nardostachyos, radix geissae, rhizoma bletillae, wild rice and the like in humid places. Rhizoma Bletillae stem is rich in multiple active ingredients, and the rhizoma bletilla of new contains water 14.6%, starch 30.48.48%, glucose 1.5%, volatile oil, mucilage, polysaccharide, etc.; the external use is daubed, can eliminate the marks left by acne on the face and chapped skin, and can make the skin smooth and traceless. Ben Cao gang mu says that it can enter lung to stop bleeding, promote tissue regeneration and treat sore. "conventional function: it can be used for treating initial sores and ulcers, or sores and abscess with ulceration and unhealed wounds, and rhagadia manus et pedis. The "materia medica summary" records: the essential herb … … for Bai Ji, astringing Qi, excreting phlegm, stopping bleeding and curing abscess is also good at promoting tissue regeneration; the "Collection of prescriptions of physicians" clearly records: when the rhizoma bletillae is ground into powder and drunk with rice, the powder can be used for treating cough, consumptive lung disease and hemoptysis. The bletilla striata stem extract obtained by the extraction method of the invention is rich in natural water-soluble polysaccharide with higher content, and can promote keratinocytes to migrate faster and earlier to realize the treatment of chapped skin.

The ribes nigrum fruit extract is rich in vitamin C and is several times to dozens of times higher than other fruits and vegetables. Ribes nigrum is a very good source of quercetin, contains much quercetin and anthocyanin, and has the effects of removing free radicals, resisting oxidation, improving immunity and resisting viruses.

The hydrolyzed hazelnut protein can promote the comprehensive renewal of epidermal and dermal cells, and recombine the barrier function of sebum by promoting the renewal of epidermal layer and improving the impermeability of epidermal layer; firming the dermis layer by promoting fibroblast growth and newcastle disease metabolism, increasing the thickness of thin skin layers and decreasing the thickness of thick skin layers.

The palmitoyl prolinesodium has an antiallergic and soothing effect. Reducing pigmentation due to inflammation (ultraviolet, irritation, acne) and aging, helping skin resist external irritation, relieving pain due to heat sensitivity, and lowering epidermal temperature. Is stable and easy to use. Also has certain cleaning effect.

The extract of Nymphaea alba, also known as Nelumbo nucifera, is a plant of the genus Nymphaea which originates from Europe. The plant natural extract contains vitamins and various nutrient components, has various effects, contains various saccharides and alcohols, also is a moisturizing component, activates a moisturizing physiological storage procedure and regulates skin moisturizing factors.

Compared with the prior art, the anti-chapping skin care product prepared by the invention has the advantages that the mutual synergistic effect of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract is utilized, the components and the content thereof are reasonably selected, the obtained anti-chapping skin care product can improve the dry skin, the crack condition and the itching and pain caused by chapping, has the good effect of treating and preventing chapping of the skin, enables the skin to keep a moist state, is not greasy when being used, and has better skin feeling.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below.

Example 1

An anti-chapping skin care lotion comprises the components with the weight percentage shown in the table 1.

TABLE 1 ingredient list of skin care lotion containing bletilla striata stem extract

The manufacturing process comprises the following steps:

1. weighing the raw materials of the component A according to the proportion shown in the reference table 1, putting the component A into a proper container, heating to 80-85 ℃, and stirring until the component A is completely dissolved to form an oil phase.

2. Weighing the raw materials of the component B according to the proportion shown in the reference table 1, putting the component B into a proper container, heating to 80-85 ℃, and stirring until the component B is completely dissolved to be used as a water phase.

3. Starting stirring speed at 20r/min, slowly adding the oil phase of the component A into the heated water phase of the component B, stirring at 40r/min, starting a homogenizer, and homogenizing for 3 min. The rotating speed is 3000 r/min.

4. Stirring, slowly cooling to 70-60 ℃, and adding the component C.

5. Stirring and cooling to 45 ℃, adding the phase D, cooling to room temperature, solidifying, adjusting the pH value to 5.0-7.0, inspecting, and discharging.

Wherein the extraction of the bletilla striata stem extract mainly comprises the following steps:

1) pulverizing rhizoma Bletillae tuber, drying, and sieving with 40-60 mesh sieve to obtain rhizoma Bletillae stem dry powder; weighing dry powder of bletilla striata stems, performing reflux extraction by using ethanol water solution with the volume concentration of 70-90%, filtering, and collecting filtrate, namely bletilla striata alcohol extract; the volume dosage of the ethanol water solution with the volume concentration of 60-90% is 5-10L/kg by weight of the dry powder of rhizoma bletillae.

2) Adding 100-120-mesh polyamide and distilled water into the filtrate obtained in the step 1), uniformly mixing, and then carrying out reduced pressure evaporation until no alcohol smell exists, thereby obtaining the polyamide suspension for adsorbing the bletilla striata alcohol extract.

3) Adding 100-120 mesh polyamide suspended in distilled water into the chromatographic column, settling, and filling the polyamide suspension absorbing the bletilla striata alcohol extract in the step 2) into the column.

4) Sequentially eluting with distilled water, 15-25% ethanol water solution with volume concentration and 35-45% ethanol water solution with volume concentration at the flow rate of 2ml/min, and collecting the eluent of the 35-45% ethanol water solution with volume concentration.

5) Adding distilled water into the ethanol eluent collected in the step 4), uniformly mixing, and performing dynamic adsorption by adopting a D101 macroporous resin column at the flow rate of 2 ml/min.

6) Sequentially eluting with 15-25% ethanol water solution and 35-45% ethanol water solution at the flow rate of 2ml/min, collecting 35-45% ethanol eluate, and evaporating under reduced pressure to obtain rhizoma bletilla crude extract;

(7) and (3) uniformly stirring the crude extract of the bletilla striata stems in the step (6) by using a butanediol aqueous solution with the volume concentration of 15-80%, standing at a low temperature (6-8 ℃) for 48 hours, and filtering to remove insoluble substances to obtain the bletilla striata stem extract.

Example 2

An anti-chapping skin cream comprises the components in percentage by weight shown in Table 2.

Table 2 raw materials of the skin cream containing the bletilla striata stem extract are listed.

The manufacturing process comprises the following steps:

1. weighing the raw materials of the component A according to the proportion shown in the reference table 2, putting the component A into a proper container, heating to 80-85 ℃, and stirring until the component A is completely dissolved to form an oil phase.

2. Weighing the raw materials of the component B according to the proportion shown in the reference table 2, putting the component B into a proper container, heating to 80-85 ℃, and stirring until the component B is completely dissolved to be used as a water phase.

4. Stirring, slowly cooling to 70-60 ℃, and adding the component C.

Wherein the extraction method of the bletilla striata stem extract is the same as that of the embodiment 1.

Example 3

A cosmetic lotion for preventing chapping comprises the components in percentage by weight shown in Table 3.

TABLE 3 ingredient list of astringent containing extract of stem of bletilla striata

The manufacturing process comprises the following steps:

1. weighing the raw material A according to the proportion shown in the reference table 3, putting the raw material A into a proper container, heating to 80-85 ℃, stirring until the raw material A is completely dissolved, keeping the temperature for 30min, and then cooling.

2. Cooling to 75-70 ℃, weighing the raw material of the component B according to the proportion shown in the material table 3, putting the component B into the component A, and stirring until the component B is completely dissolved.

3. Stirring, cooling to 45 ℃, adding the C phase, cooling to room temperature, solidifying, adjusting the pH value to 5.0-7.0, inspecting, and discharging.

Example 4

An anti-chapping skin care essence comprises the components in percentage by weight shown in Table 4.

TABLE 4 ingredient list of skin care essence containing bletilla striata stem extract

The manufacturing process comprises the following steps:

1. weighing the raw material A according to the proportion shown in the reference table 4, putting the raw material A into a proper container, heating to 80-85 ℃, stirring until the raw material A is completely dissolved, keeping the temperature for 30min, and then cooling.

2. Cooling to 60-65 ℃, weighing the raw material of the component B according to the proportion shown in the material table 3, putting the component B into the component A, and stirring until the component B is completely dissolved.

The performance test comprises the following steps:

effectiveness test of anti-chapping test of skin care products prepared according to examples 1-4.

100 cases of clinical observation are carried out, and before observation, the skin is clinically mainly manifested as skin cracking and pruritus.

1. The method comprises the following steps: the anti-chapping skin care products in examples 1-4 or skin care products purchased in the market at present (the moisturizing emulsion purchased in the market is comparative example 1, the moisturizing cream purchased in the market is comparative example 2, the moisturizing and moisturizing cream purchased in the market is comparative example 3, and the moisturizing and moisturizing essence purchased in the market is comparative example 4) or anti-chapping cream purchased in the market (X doctor foot crack cream, a certain brand, and the first word is replaced by X) is coated on the cracked and itchy skin, and the anti-chapping skin care products are used as comparative example 5. And counting the results after 3 days, 7 days and 20 days.

Table 5 test results for rhagades healing of example 1

Table 6 test results for rhagades healing of example 2

Table 7 test results for chapped skin healing of example 3

Table 8 test results for rhagades healing of example 4

2. And (4) trial results: the skin care products of examples 1-4 are quick, the effective rate or cure rate can reach more than 80% in 3 days, and the effective rate or cure rate can reach more than 84% in 7 days. Up to 100% effective or curative in 20 days. Therefore, the anti-chapping skin care product has obvious effects of preventing chapping and curing chapping and chapping of skin.

Example 5

The bletilla striata stem extract of example 2 was removed and the water content was adjusted to 100%. The other components and their contents were unchanged. The preparation method is the same as example 2.

Example 6

The ribes nigrum fruit extract in example 2 is removed, and the water content is adjusted to 100 percent. The other components and their contents were unchanged. The preparation method is the same as example 2.

Example 7

The hydrolyzed hazelnut protein of example 2 was removed and the water content was adjusted to 100%. The other components and their contents were unchanged. The preparation method is the same as example 2.

Example 8

The sodium palmitoylprolinate of example 2 was removed and the water content was adjusted to 100%. The other components and their contents were unchanged. The preparation method is the same as example 2.

Example 9

The water content was adjusted to 100% by removing the water lily extract of example 2. The other components and their contents were unchanged. The preparation method is the same as example 2.

Example 10

Adjusting the mass ratio of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract in example 2 to 10: 10: 1: 1: 1. the total mass of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract is unchanged. The other components and their contents were unchanged. The preparation method is the same as example 2.

Example 11

The mass ratio of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract in the embodiment 2 is 10: 6: 1: 1: 2. the total mass of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract is unchanged. The other components and their contents were unchanged. The preparation method is the same as example 2.

Example 12

The mass ratio of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract in the embodiment 2 is 10: 1: 1: 1: 1. the total mass of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract is unchanged. The other components and their contents were unchanged. The preparation method is the same as example 2.

And (5) performance test II:

270 workers (mainly construction workers and sanitation workers) with seriously cracked hands are selected in 11 months in 2018, and the skin of the hands is thickened, dry, cracked and slightly bleeding, and is accompanied by pruritus and pain. The chapped-preventing skin cream prepared in example 2 and examples 5 to 9 was applied to chapped skin by randomly dividing into 9 groups, and 30 persons in each group were each applied once in the morning and once in the evening, and the effect was observed after one week of use.

TABLE 9 results of the tests for chapped skin resistance of examples 2 and 5 to 12

And (3) performance test:

and 2018, and 270 factory workers with severe chaps of hands and/or feet in 8-10 months of continuous two years (2016 and 2017) are selected in 8 months of the year. The anti-chap skin cream prepared in example 2 and examples 5-9 was applied to the hands and feet of 30 persons each in 9 groups, once in the morning and at night, and the effect was observed after three months of use.

TABLE 10 results of the tests for chapped skin prevention of examples 2 and 5-12

	The number of people with slight rhagadia	Number of severe chapping	The number of people without chapping
				Example 2	5	0	25
Example 5	14	13	3
				Example 6	9	1	20
Example 7	8	3	19
				Example 8	7	2	21
Example 9	9	3	18
				Example 10	8	2	20
Example 11	7	0	23
				Example 12	6	1	23

Example 13

The content of the bletilla striata stem extract in example 2 was set to 0.5%, 1.0%, 4.0%, 10%, respectively, and the water content was adjusted to 100%. The other components and their contents were unchanged. The preparation method is the same as example 2. When the content of the bletilla striata stem extract is 0.5%, the anti-rhagadia effect is not obvious. The content of 1.0%, 4.0% and 10% of the bletilla striata stem extract is not as good as that of example 2 in anti-chapping effect.

Example 14

The content of the ribes nigrum fruit extract in example 2 is respectively set to be 0.5%, 1%, 5% and 10%, and the water content is adjusted to be 100%. The other components and their contents were unchanged. The preparation method is the same as example 2. The chapping-resistant effect was inferior to that of example 2.

Example 15

The content of hydrolyzed hazelnut protein in example 2 was set to 0.1%, 1%, 3%, 5%, respectively, and the water content was adjusted to 100%. The other components and their contents were unchanged. The preparation method is the same as example 2. The chapping-resistant effect was inferior to that of example 2.

Example 16

The content of sodium palmitoylprolinate in example 2 was adjusted to 0.1%, 1%, 2%, and 5%, respectively, and the water content was adjusted to 100%. The other components and their contents were unchanged. The preparation method is the same as example 2. The chapping-resistant effect was inferior to that of example 2.

Example 17

The content of the water lily flower extract in example 2 was set to 0.1%, 1%, 2%, 5%, respectively, and the water content was adjusted to 100%. The other components and their contents were unchanged. The preparation method is the same as example 2. The chapping-resistant effect was inferior to that of example 2.

Claims

1. The anti-chapping skin care product is characterized by comprising the following components in percentage by weight:

1.0-5.0% of bletilla striata stem extract

1-20.0% of oil

0.1 to 20.0 percent of phytosterol isostearate

Ribes nigrum fruit extract 1-5.0%

0.5 to 3 percent of hydrolyzed hazelnut protein

0.5-2% of palmitoyl proline sodium

0.5-2% of water lily flower extract

0.01 to 10.0 percent of emulsifying thickener

0.5-20.0% of polyhydric alcohol humectant.

0.1 to 5.0 percent of urea

0.1-2.0% of essence

0.01 to 0.1 percent of chelating agent

0.01 to 2.0 percent of neutralizer

0.01 to 2.0 percent of preservative

Adding water to 100%;

the extraction method of the bletilla striata stem extract mainly comprises the following steps:

2. The anti-chapping skin care product according to claim 1, wherein the weight ratio of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the nymphaea alba extract is 10: 6: 1: 1: 1.

3. the anti-chapping skin care product according to claim 1, wherein the content of the bletilla striata stem extract, the ribes nigrum fruit extract, the hydrolyzed hazelnut protein, the sodium palmitoyl prolinate and the water lily flower extract are respectively 5.0%, 3.0%, 0.5% and 0.5% by weight.

4. The anti-chapping skin care product according to claim 1, wherein the pH value is 5.0 to 7.0.

5. The anti-chapping skin care product according to claim 1, wherein the skin care product comprises skin care lotion, skin care cream, cosmetic water and skin care essence.

6. The anti-chapping skin care product according to claim 1, wherein the thickening emulsifier is hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

7. The method for preparing the skin care product for preventing chapping according to claim 1, which mainly comprises the following steps:

(4) stirring, slowly cooling to 70-60 ℃, and adding a neutralizer;

(5) stirring and cooling to 45 deg.C, adding antiseptic, essence and rhizoma Bletillae stem extract, Ribes nigrum fruit extract, hydrolyzed hazelnut protein, palmitoyl proline sodium, and flos Nymphaeae extract, cooling to room temperature, and adjusting pH.