CN113476394A - Composition for effectively regulating dryness and desquamation of skin and preparation method and application thereof - Google Patents
Composition for effectively regulating dryness and desquamation of skin and preparation method and application thereof Download PDFInfo
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- CN113476394A CN113476394A CN202110893063.4A CN202110893063A CN113476394A CN 113476394 A CN113476394 A CN 113476394A CN 202110893063 A CN202110893063 A CN 202110893063A CN 113476394 A CN113476394 A CN 113476394A
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- skin
- ceramide
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- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims abstract description 4
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- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 208000010744 skin desquamation Diseases 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 210000000438 stratum basale Anatomy 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 210000000439 stratum lucidum Anatomy 0.000 description 1
- 210000000437 stratum spinosum Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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Abstract
The invention discloses a composition for effectively regulating skin dryness and desquamation, a preparation method and application thereof, wherein the composition comprises the following components: water, artemia salina extract, tridecyl alcohol trimellitate, hydrogenated polyisobutene, salvia miltiorrhiza root extract, clove bud extract, scutellaria baicalensis root extract, angelica root extract, licorice root extract, centella asiatica extract, phytosphingosine, glycerol polyacrylate, PVM/MA copolymer, polyacrylate-13, polyisobutylene, polydimethylsiloxane, acrylates/C10-30 alkanol acrylate crosspolymer, octyldodecanol, patchouli leaf extract, ceramide 3, ceramide 6II, ceramide 1 and the like. The invention also provides a preparation method and application of the composition. The composition prepared by the invention can be used for pertinently solving desquamation of skin caused by different reasons, and can promote skin barrier repair, keep moisture for a long time, realize broad-spectrum antibacterial and deep anti-inflammatory functions and the like.
Description
Technical Field
The invention relates to a composition for regulating skin dryness and desquamation in the field of cosmetics, and a preparation method and application thereof, in particular to a composition for effectively regulating skin dryness and desquamation, and a preparation method and application thereof.
Background
Dry skin is a common skin condition that manifests as dry, rough, lusterless, taut skin, possibly with desquamation, chapping. Dry desquamation of skin is mainly caused by lack of water in the skin. The skin is divided into epidermis, dermis and hypodermis from the outside to the inside, and the epidermis is divided into stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum and stratum basale. A sebum membrane is arranged on the outermost stratum corneum layer to moisturize skin. The stratum corneum and sebaceous membrane prevent the loss of water from the skin. Seasonal changes, dry weather, excessive bathing and other factors can cause sebum loss and skin moisture content reduction, thereby causing symptoms such as dry skin and desquamation. Due to the complexity and repeatability of the causes of desquamation, the existing treatment method has weak persistence, and healthy skin care products which can durably and effectively regulate desquamation of skin, repair barrier function and maintain skin steady state are rare.
Disclosure of Invention
The invention aims to provide a composition which is suitable for all skin types and can quickly and effectively regulate skin dryness and desquamation, a preparation method thereof and application thereof in skin care products, can solve the existing problems, aims at the skin dryness and desquamation caused by different reasons, and can promote skin barrier repair, long-term moisture retention, broad-spectrum antibiosis, deep anti-inflammatory function and the like.
In order to achieve the above object, the present invention provides a composition effective for regulating desquamation of dry skin, wherein the composition comprises a phase A, a phase B, a phase C, a phase D; phase A comprises water, artemia salina extract, tridecyl alcohol trimellitate, hydrogenated polyisobutene, radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, herba Centellae extract, phytosphingosine, glycerol polyacrylate, PVM/MA copolymer, and polyacrylate-13; phase B comprises polyisobutylene, polydimethylsiloxane, acrylate/C10-30 alkanol acrylate cross-linked polymer, octyldodecanol, patchouli leaf extract, ceramide 3, ceramide 6II, ceramide 1, and sodium tocopheryl phosphate; the phase C comprises cholesterol, sodium lauroyl lactylate and carbomer; the phase D comprises xanthan gum, polysorbate-20, phenoxyethanol, octyl glycol, methyl hydroxybenzoate, triethanolamine, potassium sorbate, EDTA disodium, propyl hydroxybenzoate, and ethylhexyl glycerol.
The composition for effectively regulating skin dryness and desquamation comprises the following components in parts by weight: 2-4 parts of artemia salina extract, 2-4 parts of tridecanol trimellitate, 2-3 parts of hydrogenated polyisobutene, 0.5-1.5 parts of salvia miltiorrhiza root extract, 0.5-1.5 parts of clove bud extract, 0.5-1.5 parts of scutellaria baicalensis root extract, 0.5-1.5 parts of angelica root extract, 0.5-1.5 parts of liquorice root extract, 0.5-1.5 parts of centella asiatica extract, 2-4 parts of phytosphingosine, 2-4 parts of glycerol polyacrylate, 2-3 parts of PVM/MA copolymer, 132-3 parts of polyacrylate, 1-3 parts of polyisobutene, 2-3 parts of polydimethylsiloxane, 0.5-1.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1-2 parts of octyldodecanol, 2-4 parts of pogostemon leaf extract, 34-6 parts of ceramide, 6 parts of ceramide II, 14-6 parts of ceramide, 2-4 parts of sodium phosphate, 2-4 parts of cholesterol, 0.4-0.6 part of sodium lauroyl lactylate, 0.05-0.15 part of carbomer, 0.4-0.6 part of xanthan gum, 200.1-0.3 part of polysorbate, 0.04-0.06 part of phenoxyethanol, 0.05-0.15 part of caprylyl glycol, 0.1-0.3 part of methyl hydroxybenzoate, 0.04-0.06 part of triethanolamine, 0.02-0.04 part of potassium sorbate, 0.04-0.06 part of EDTA disodium, 0.005-0.015 part of propyl hydroxybenzoate and 0.05-0.15 part of ethylhexylglycerin.
The composition for effectively regulating skin dryness and desquamation comprises the following components in percentage by mass: 3% of artemia salina extract, 3% of tridecyl alcohol trimellitate, 2.5% of hydrogenated polyisobutene, 1% of salvia miltiorrhiza root extract, 1% of clove bud extract, 1% of scutellaria baicalensis root extract, 1% of angelica root extract, 1% of licorice root extract, 1% of centella asiatica extract, 3% of phytosphingosine, 3% of glycerol polyacrylate, 2.5% of PVM/MA copolymer, 132.5% of polyacrylate-132.5%, 2% of polyisobutene, 2.5% of polydimethylsiloxane, 1% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1.5% of dodecanol, 3% of patchouli extract, 35% of ceramide, 6II 5% of ceramide, 15% of ceramide, 3% of sodium tocopheryl phosphate, 3% of cholesterol, 0.5% of sodium lauroyl lactylate, 0.1% of carbomer, 0.5% of xanthan gum, 200.2% of polysorbate-200.2% 0.05% of phenoxyethanol, 0.1% of caprylyl glycol, 0.2% of methylparaben, 0.05% of triethanolamine, 0.03% of potassium sorbate, 0.05% of disodium EDTA, 0.01% of propylparaben and 0.1% of ethylhexylglycerin.
The composition for effectively regulating skin dryness and desquamation is characterized in that water is added into the composition to 100% by mass percent.
The invention also provides a preparation method of the composition for effectively regulating skin dryness and desquamation, wherein the method comprises the following steps: step 1, weighing raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase; step 2, respectively heating the phase A and the phase B; step 3, adding the phase B into the phase A, and emulsifying uniformly; step 4, adding the phase C, and continuing to emulsify uniformly; and 5, cooling, adding the phase D, and uniformly stirring.
In the above method for preparing the composition effective in regulating skin dryness and desquamation, in step 2, the phase a and the phase B are heated to 80 ℃ respectively.
In the preparation method of the composition for effectively regulating skin dryness and desquamation, in the step 3, the phase B is added into the phase A and emulsified for 2 minutes.
In the preparation method of the composition for effectively regulating skin dryness and desquamation, in the step 4, the phase C is added, and emulsification is continued for 2 minutes.
In the step 5, after cooling to 40 ℃, the phase D is added and stirred uniformly.
The invention also provides the use of the composition prepared by the method for effectively regulating the dryness and desquamation of the skin, wherein the composition is used for preparing a skin care product; the skin care product comprises an emulsion.
The composition for effectively regulating the dryness and desquamation of the skin, the preparation method and the application thereof provided by the invention have the following advantages:
the composition for effectively regulating skin dryness and desquamation, which is disclosed by the invention, combines a ceramide composition, sodium tocopheryl phosphate, an artemia salina extract, a patchouli plant extract and other plant extracts (salvia miltiorrhiza, clove, scutellaria baicalensis, angelica sinensis, liquorice, centella asiatica and the like) for the first time, is suitable for various skin dryness and desquamation symptoms, can form a natural skin barrier, has the functions of moisturizing, water locking, inflammation resistance, bacteriostasis and the like while quickly repairing the skin, and thus improves dry and sensitive skin, and keeps the moisture and health of the skin.
The composition can effectively regulate symptoms of skin dryness and desquamation, relieve discomfort caused by skin dryness, rapidly relieve inflammatory reaction caused by skin dryness, and has super-strong moisture-keeping ability, and can form natural skin barrier, retain moisture and water, and resist inflammation and bacteria.
Detailed Description
The following further describes embodiments of the present invention.
The composition for effectively regulating the dryness and desquamation of the skin comprises a phase A, a phase B, a phase C and a phase D; phase A comprises water, artemia salina extract, tridecyl alcohol trimellitate, hydrogenated polyisobutene, radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, herba Centellae extract, phytosphingosine, glycerol polyacrylate, PVM/MA copolymer, and polyacrylate-13; phase B comprises polyisobutylene, polydimethylsiloxane, acrylate/C10-30 alkanol acrylate cross-linked polymer, octyldodecanol, patchouli leaf extract, ceramide 3, ceramide 6II, ceramide 1, and sodium tocopheryl phosphate; the phase C comprises cholesterol, sodium lauroyl lactylate and carbomer; the phase D comprises xanthan gum, polysorbate-20, phenoxyethanol, octyl glycol, methyl hydroxybenzoate, triethanolamine, potassium sorbate, EDTA disodium, propyl hydroxybenzoate, and ethylhexyl glycerol.
Preferably, the composition comprises the following components in parts by weight: 2-4 parts of artemia salina extract, 2-4 parts of tridecanol trimellitate, 2-3 parts of hydrogenated polyisobutene, 0.5-1.5 parts of salvia miltiorrhiza root extract, 0.5-1.5 parts of clove bud extract, 0.5-1.5 parts of scutellaria baicalensis root extract, 0.5-1.5 parts of angelica root extract, 0.5-1.5 parts of liquorice root extract, 0.5-1.5 parts of centella asiatica extract, 2-4 parts of phytosphingosine, 2-4 parts of glycerol polyacrylate, 2-3 parts of PVM/MA copolymer, 132-3 parts of polyacrylate, 1-3 parts of polyisobutene, 2-3 parts of polydimethylsiloxane, 0.5-1.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1-2 parts of octyldodecanol, 2-4 parts of pogostemon leaf extract, 34-6 parts of ceramide, 6 parts of ceramide II, 14-6 parts of ceramide, 2-4 parts of sodium phosphate, 2-4 parts of cholesterol, 0.4-0.6 part of sodium lauroyl lactylate, 0.05-0.15 part of carbomer, 0.4-0.6 part of xanthan gum, 200.1-0.3 part of polysorbate, 0.04-0.06 part of phenoxyethanol, 0.05-0.15 part of caprylyl glycol, 0.1-0.3 part of methyl hydroxybenzoate, 0.04-0.06 part of triethanolamine, 0.02-0.04 part of potassium sorbate, 0.04-0.06 part of EDTA disodium, 0.005-0.015 part of propyl hydroxybenzoate and 0.05-0.15 part of ethylhexylglycerin.
More preferably, the composition comprises the following components in percentage by mass: 3% of artemia salina extract, 3% of tridecyl alcohol trimellitate, 2.5% of hydrogenated polyisobutene, 1% of salvia miltiorrhiza root extract, 1% of clove bud extract, 1% of scutellaria baicalensis root extract, 1% of angelica root extract, 1% of licorice root extract, 1% of centella asiatica extract, 3% of phytosphingosine, 3% of glycerol polyacrylate, 2.5% of PVM/MA copolymer, 132.5% of polyacrylate-132.5%, 2% of polyisobutene, 2.5% of polydimethylsiloxane, 1% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1.5% of dodecanol, 3% of patchouli extract, 35% of ceramide, 6II 5% of ceramide, 15% of ceramide, 3% of sodium tocopheryl phosphate, 3% of cholesterol, 0.5% of sodium lauroyl lactylate, 0.1% of carbomer, 0.5% of xanthan gum, 200.2% of polysorbate-200.2% 0.05% of phenoxyethanol, 0.1% of caprylyl glycol, 0.2% of methylparaben, 0.05% of triethanolamine, 0.03% of potassium sorbate, 0.05% of disodium EDTA, 0.01% of propylparaben and 0.1% of ethylhexylglycerin.
The composition is added with water to 100 percent by mass percent.
The main functional components of the composition of the invention are as follows: ceramide composition, ARTEMIA salina (ARTEMIA) extract, sodium tocopheryl phosphate, Pogostemon CABLIN (Pogostemon CABLIN) leaf extract and other plant extracts (Saviae Miltiorrhizae radix (Salvia Miltiorrhiza) root extract, flos Caryophylli (Eugenia CARYOPHYLLUS) bud extract, Scutellariae radix (Scutellaria BAICALENSIS) root extract, Glycyrrhrizae radix extract, radix Angelicae SINENSIS (Angelica POLYMORPHA SINENSIS) root extract, herba Centellae (CENTELLA ASIATICA) extract and/or extract thereof)
The ceramide composition is a natural stratum corneum of a human body, can repair skin barriers, improve an autoimmune system and eliminate skin inflammation, thereby achieving the purposes of quickly supplementing water, repairing skin, relieving dry and desquamation of skin, relieving discomfort of skin and the like. Meanwhile, the skin moisturizing cream has super moisturizing capability, can lock water with high energy accumulation, and can adjust the water-oil balance of the skin for a long time.
The cannabinoid receptor 2(CB2) activator in the patchouli (POGOSTEMON CABLIN) leaf extract can effectively activate a CB2 receptor, inhibit a TRPV1 receptor and synthesize beta-endorphin, thereby achieving the aims of quickly replenishing water and repairing skin, quickly repairing desquamation of skin, effectively relieving symptoms such as dry desquamation of skin and the like, and further moisturizing and desensitizing.
Artemia extract (i.e., GP4G), nucleotides obtained from extremophilic plankton. Firstly, the cell factor can be activated, various physiological activities and metabolism of human skin can be effectively regulated, the absorption of the skin to water is accelerated, and the damaged skin barrier is quickly repaired. And secondly, the skin care product can resist various types of pressure on the skin caused by various external factors such as multiple factors such as seasonal variation, excessive bathing, seasonal dryness and the like, protect protein, nucleic acid and mitochondrial components in cells, can quickly protect and repair skin cells, and has strong whitening and moisturizing effects.
The sodium tocopheryl phosphate is vitamin E, and can utilize hydroxyl in tocopherol to chemically modify and protect skin cells, avoid oxidation, promote TPNa (R) absorbed by skin, and quickly hydrolyze and convert phosphatase in the skin into active tocopherol to further play a role. It has strong capability of eliminating various inflammations caused by external factors, and can promote the synthesis of ceramide in skin,
forming a high moisture-retaining skin barrier, and achieving the double effects of high water replenishing and moisture retaining.
The root extract of Salvia MILTIORRHIZA (Salvia Miltiorrhiza) has antiinflammatory and antibacterial effects, and can effectively inhibit sebaceous gland cell proliferation, thereby reducing sebaceous gland cell volume and moisturizing.
Baicalin and baicalein in the radix Scutellariae extract can inhibit inflammatory reaction caused by cytokine specificity, and has broad-spectrum antibacterial effect. Therefore, it can relieve various inflammatory reactions caused by dry and desquamated skin, and enhance the anti-allergy ability of the skin.
The angelica root extract can control the expansion of vascular endothelial cells, has good SOD-like activity, can inhibit peroxidation and free radical reaction, is combined with phospholipid to protect a biological membrane, has extremely strong skin repair capacity, and has the effects of repairing skin barriers and keeping moisture for a long time.
The Glycyrrhrizae radix extract can promote proliferation of muscle cell and vascular endothelial cell, promote generation of collagen, inhibit generation of NO, enhance skin immunity, resist inflammation, reduce oxidation rate, improve desquamation phenomenon of skin, and relieve dry skin.
The centella asiatica extract is plant collagen, and can promote skin collagen regeneration, enhance cell basal layer cell activity, regulate skin immunity, and repair skin barrier.
The invention also provides a preparation method of the composition for effectively regulating skin dryness and desquamation, which comprises the following steps: step 1, weighing raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase; step 2, respectively heating the phase A and the phase B; step 3, adding the phase B into the phase A, and emulsifying uniformly; step 4, adding the phase C, and continuing to emulsify uniformly; and 5, cooling, adding the phase D, and uniformly stirring.
In step 2, phase A and phase B are heated to 80 ℃ respectively.
In step 3, add phase B to phase A and emulsify for 2 minutes.
In step 4, add phase C and continue to emulsify for 2 minutes.
And 5, cooling to 40 ℃, adding the phase D, and uniformly stirring.
The invention also provides the use of the composition prepared by the method, which is effective in regulating the dryness and desquamation of the skin, in the preparation of skin care products; the skin care product comprises an emulsion.
The compositions for effectively regulating skin dryness and desquamation provided by the present invention, and the preparation method and use thereof are further described below with reference to the following examples.
Example 1
A composition effective in regulating dryness and desquamation of skin is provided, and the ingredients are shown in Table 1 below. All the raw materials respectively accord with the corresponding national standards.
Table 1 composition formulation table (in mass percent).
The embodiment also provides a preparation method of the composition for effectively regulating skin dryness and desquamation, which comprises the following steps:
step 1, weighing the raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase.
And 2, heating the phase A and the phase B to 80 ℃ respectively.
And 3, adding the phase B into the phase A, and emulsifying for 2 minutes to ensure that the phase B is uniformly emulsified.
And 4, adding the phase C, and continuing to emulsify for 2 minutes to ensure that the emulsion is uniform.
And 5, cooling to 40 ℃, adding the phase D, and uniformly stirring.
The embodiment also provides the application of the composition prepared by the method and effective in regulating the dryness and desquamation of the skin, and the composition is used for preparing a skin care product; the skin care product comprises an emulsion.
Example 2
A composition effective in regulating dryness and desquamation of skin comprises the following components in parts by weight:
2 parts of artemia salina extract, 2 parts of tridecyl alcohol trimellitate, 2 parts of hydrogenated polyisobutene, 0.5 part of salvia miltiorrhiza extract, 0.5 part of clove bud extract, 0.5 part of scutellaria baicalensis root extract, 0.5 part of angelica root extract, 0.5 part of licorice root extract, 0.5 part of centella asiatica extract, 2 parts of phytosphingosine, 2 parts of glycerol polyacrylate, 2 parts of PVM/MA copolymer, polyacrylate-132 parts, 1 part of polyisobutene, 2 parts of polydimethylsiloxane, 0.5 part of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1 part of octyl dodecanol, 2 parts of patchouli leaf extract, 34 parts of ceramide, 6II4 parts of ceramide, 14 parts of ceramide, 2 parts of sodium tocopheryl phosphate, 2 parts of cholesterol, 0.4 part of sodium lauroyl lactylate, 0.05 part of carbomer, 0.4 part of xanthan gum, 200.1 part of polysorbate, 1 part of sodium lauroyl lactylate, and the like, 0.04 part of phenoxyethanol, 0.05 part of caprylyl glycol, 0.1 part of methyl hydroxybenzoate, 0.04 part of triethanolamine, 0.02 part of potassium sorbate, 0.04 part of EDTA disodium, 0.005 part of propyl hydroxybenzoate and 0.05 part of ethylhexyl glycerol.
Finally, water is added into the composition to 100 parts by weight.
The embodiment also provides a preparation method of the composition for effectively regulating skin dryness and desquamation, which comprises the following steps:
step 1, weighing the raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase.
And 2, heating the phase A and the phase B to 80 ℃ respectively.
And 3, adding the phase B into the phase A, and emulsifying for 2 minutes to ensure that the phase B is uniformly emulsified.
And 4, adding the phase C, and continuing to emulsify for 2 minutes to ensure that the emulsion is uniform.
And 5, cooling to 40 ℃, adding the phase D, and uniformly stirring.
The embodiment also provides the application of the composition prepared by the method and effective in regulating the dryness and desquamation of the skin, and the composition is used for preparing a skin care product; the skin care product comprises an emulsion.
Example 3
A composition effective in regulating dryness and desquamation of skin comprises the following components in parts by weight:
4 parts of artemia salina extract, 4 parts of tridecyl alcohol trimellitate, 3 parts of hydrogenated polyisobutene, 1.5 parts of salvia miltiorrhiza extract, 1.5 parts of clove bud extract, 1.5 parts of scutellaria baicalensis extract, 1.5 parts of angelica root extract, 1.5 parts of licorice root extract, 1.5 parts of centella asiatica extract, 4 parts of phytosphingosine, 4 parts of glycerol polyacrylate, 3 parts of PVM/MA copolymer, 133 parts of polyacrylate-133, 3 parts of polyisobutene, 3 parts of polydimethylsiloxane, 1.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 2 parts of octyl dodecanol, 4 parts of patchouli leaf extract, 36 parts of ceramide, 6II6 parts of ceramide, 16 parts of ceramide, 4 parts of sodium tocopheryl phosphate, 4 parts of cholesterol, 0.6 part of sodium lauroyl lactylate, 0.15 part of carbomer, 0.6 part of xanthan gum, 200.3 parts of polysorbate-200.3 parts of, 0.06 part of phenoxyethanol, 0.15 part of caprylyl glycol, 0.3 part of methyl hydroxybenzoate, 0.06 part of triethanolamine, 0.04 part of potassium sorbate, 0.06 part of EDTA disodium, 0.015 part of propyl hydroxybenzoate and 0.15 part of ethylhexyl glycerol.
Finally, water is added into the composition to 100 parts by weight.
The embodiment also provides a preparation method of the composition for effectively regulating skin dryness and desquamation, which comprises the following steps:
step 1, weighing the raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase.
And 2, heating the phase A and the phase B to 80 ℃ respectively.
And 3, adding the phase B into the phase A, and emulsifying for 2 minutes to ensure that the phase B is uniformly emulsified.
And 4, adding the phase C, and continuing to emulsify for 2 minutes to ensure that the emulsion is uniform.
And 5, cooling to 40 ℃, adding the phase D, and uniformly stirring.
The embodiment also provides the application of the composition prepared by the method and effective in regulating the dryness and desquamation of the skin, and the composition is used for preparing a skin care product; the skin care product comprises an emulsion.
The compositions prepared in the examples were tested and evaluated in the following manner.
1. Test object
Experimental group (invention): 30 cases, 15 men and 25 women; the age is 20-60 years old;
control group (placebo-general moisturizer): 30 cases, 15 men and 15 women, age 19-61 years.
The data of sex, age, etc. of two groups of people are statistically processed, the difference is not statistically significant (P >0.05), and the two groups are comparable.
2. Treatment mode, the skin dryness and desquamation part of the experimental group is coated with the invention, the skin dryness and desquamation part of the control group is coated with the common moisturizing liquid, the healing time and the repeated condition of the skin dryness and desquamation are recorded within 15 days, the following evaluation is carried out, and the occurrence of the uncomfortable reaction is recorded.
3. Evaluation criteria:
evaluation was made on the basis of dry skin, itching, redness, stinging and desquamation.
And (3) healing: the symptoms and signs are resolved by more than 95%.
The effect is shown: the clinical manifestation is reduced by 80 to 94 percent.
Improvement: the clinical manifestation is reduced by 50 to 79 percent.
And (4) invalidation: no improvement in clinical manifestations.
And (3) relapse: improved, effective and the clinical manifestations reappear after recovery.
4. As a result: the results are shown in table 2 below.
Table 2 table of test results.
The difference analysis (P is less than 0.05) of the experimental group and the control group has obvious difference, and the statistical significance is achieved. The effective action time of the experimental group is obviously shorter than that of the control group, the experimental group has no relapse within 5 days, the control group has obvious relapse, the experimental group can quickly and persistently recover the symptoms of the dry and desquamative skin, and simultaneously, the experimental group does not generate discomfort, so that the invention has good effect.
Among the components adopted by the invention, the ceramide composition can improve the autoimmune system and eliminate skin inflammation, thereby achieving the aims of quickly supplementing moisture and relieving discomfort such as dry skin, desquamation and the like. Meanwhile, the skin moisturizing cream has super-strong moisturizing capability and can adjust the water-oil balance of the skin for a long time. The artemia salina extract (GP 4G) can effectively regulate various physiological activities and metabolism of human skin, accelerate the absorption of the skin to moisture and quickly repair damaged skin barriers; can resist various types of pressure on the skin caused by external factors; has good whitening and moisturizing effects. The sodium tocopheryl phosphate has strong capacity of eliminating various inflammations caused by external factors, and can also promote the synthesis of ceramide in the skin, form a high-moisture-retention skin barrier and achieve the double effects of high water supplement and moisture retention. The patchouli leaf extract can quickly relieve allergy and itching, quickly repair skin desquamation and further preserve moisture.
The composition for effectively regulating the dryness and desquamation of the skin, the preparation method and the application thereof provided by the invention have the functions of quickly replenishing water, repairing skin barriers, moisturizing and locking water, resisting inflammation and inhibiting bacteria and the like, and can achieve the effect of effectively regulating the dryness and desquamation of the skin, thereby improving the dry skin and keeping the moisture and health of the skin for a long time.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.
Claims (10)
1. A composition effective in regulating dryness and desquamation of skin, wherein the composition comprises phase A, phase B, phase C, phase D;
phase A comprises water, artemia salina extract, tridecyl alcohol trimellitate, hydrogenated polyisobutene, radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, herba Centellae extract, phytosphingosine, glycerol polyacrylate, PVM/MA copolymer, and polyacrylate-13;
phase B comprises polyisobutylene, polydimethylsiloxane, acrylate/C10-30 alkanol acrylate cross-linked polymer, octyldodecanol, patchouli leaf extract, ceramide 3, ceramide 6II, ceramide 1, and sodium tocopheryl phosphate;
the phase C comprises cholesterol, sodium lauroyl lactylate and carbomer;
the phase D comprises xanthan gum, polysorbate-20, phenoxyethanol, octyl glycol, methyl hydroxybenzoate, triethanolamine, potassium sorbate, EDTA disodium, propyl hydroxybenzoate, and ethylhexyl glycerol.
2. The composition effective in regulating dryness and desquamation of skin of claim 1, wherein said composition comprises, in parts by weight: 2-4 parts of artemia salina extract, 2-4 parts of tridecanol trimellitate, 2-3 parts of hydrogenated polyisobutene, 0.5-1.5 parts of salvia miltiorrhiza root extract, 0.5-1.5 parts of clove bud extract, 0.5-1.5 parts of scutellaria baicalensis root extract, 0.5-1.5 parts of angelica root extract, 0.5-1.5 parts of liquorice root extract, 0.5-1.5 parts of centella asiatica extract, 2-4 parts of phytosphingosine, 2-4 parts of glycerol polyacrylate, 2-3 parts of PVM/MA copolymer, 132-3 parts of polyacrylate, 1-3 parts of polyisobutene, 2-3 parts of polydimethylsiloxane, 0.5-1.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1-2 parts of octyldodecanol, 2-4 parts of pogostemon leaf extract, 34-6 parts of ceramide, 6 parts of ceramide II, 14-6 parts of ceramide, 2-4 parts of sodium phosphate, 2-4 parts of cholesterol, 0.4-0.6 part of sodium lauroyl lactylate, 0.05-0.15 part of carbomer, 0.4-0.6 part of xanthan gum, 200.1-0.3 part of polysorbate, 0.04-0.06 part of phenoxyethanol, 0.05-0.15 part of caprylyl glycol, 0.1-0.3 part of methyl hydroxybenzoate, 0.04-0.06 part of triethanolamine, 0.02-0.04 part of potassium sorbate, 0.04-0.06 part of EDTA disodium, 0.005-0.015 part of propyl hydroxybenzoate and 0.05-0.15 part of ethylhexylglycerin.
3. The composition effective in regulating dryness and desquamation of skin according to claim 2, wherein said composition comprises, in mass percent: 3% of artemia salina extract, 3% of tridecyl alcohol trimellitate, 2.5% of hydrogenated polyisobutene, 1% of salvia miltiorrhiza root extract, 1% of clove bud extract, 1% of scutellaria baicalensis root extract, 1% of angelica root extract, 1% of licorice root extract, 1% of centella asiatica extract, 3% of phytosphingosine, 3% of glycerol polyacrylate, 2.5% of PVM/MA copolymer, 132.5% of polyacrylate-132.5%, 2% of polyisobutene, 2.5% of polydimethylsiloxane, 1% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1.5% of dodecanol, 3% of patchouli extract, 35% of ceramide, 6II 5% of ceramide, 15% of ceramide, 3% of sodium tocopheryl phosphate, 3% of cholesterol, 0.5% of sodium lauroyl lactylate, 0.1% of carbomer, 0.5% of xanthan gum, 200.2% of polysorbate-200.2% 0.05% of phenoxyethanol, 0.1% of caprylyl glycol, 0.2% of methylparaben, 0.05% of triethanolamine, 0.03% of potassium sorbate, 0.05% of disodium EDTA, 0.01% of propylparaben and 0.1% of ethylhexylglycerin.
4. A composition effective in regulating dryness and desquamation of skin according to claim 3, wherein said composition comprises water in an amount up to 100% by weight.
5. A method for preparing a composition effective in regulating dryness and desquamation of skin according to any one of claims 1 to 4, wherein said method comprises:
step 1, weighing raw materials in proportion, and dividing the raw materials into an A phase, a B phase, a C phase and a D phase;
step 2, respectively heating the phase A and the phase B;
step 3, adding the phase B into the phase A, and emulsifying uniformly;
step 4, adding the phase C, and continuing to emulsify uniformly;
and 5, cooling, adding the phase D, and uniformly stirring.
6. The method of claim 5, wherein in step 2, phase A and phase B are heated to 80 ℃ respectively.
7. The method of claim 5, wherein in step 3, phase B is added to phase A and emulsified for 2 minutes.
8. The method of claim 5, wherein in step 4, phase C is added and emulsification is continued for 2 minutes.
9. The method of claim 5, wherein in step 5, after cooling to 40 ℃, phase D is added and stirred until homogeneous.
10. Use of a composition effective in regulating dryness and desquamation of skin prepared by the method of claim 5, wherein said composition is used to prepare a skin care product; the skin care product comprises an emulsion.
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