CN111643402B - Acne-removing composition containing saw palmetto essential oil and preparation method thereof - Google Patents

Abstract

The invention discloses an acne-removing composition containing sawpalmetto essential oil and a preparation method thereof, the raw materials of the acne-removing composition comprise 0.05-0.1 part by weight of sawpalmetto essential oil, 0.01-0.05 part by weight of angelica ferulic acid, 0.5-2 parts by weight of pueraria isoflavone, 0.5-3 parts by weight of wheat protein extract, 1-10 parts by weight of salicylic acid, 1-5 parts by weight of nicotinamide, 0.5-5 parts by weight of citric acid and 0.1-3 parts by weight of zinc gluconate, 0.5-2 parts of aloe vera extract freeze-dried powder, 0.05-1 part of patchouli essential oil, 0.01-0.1 part of chamomile essential oil, 0.5-3 parts of allantoin, 0.2-0.5 part of hyaluronic acid, 0.1-0.5 part of dipotassium glycyrrhizinate, 1-8 parts of plant antibacterial component composition and 0.5-1 part of arbutin. The composition provided by the invention effectively blocks the pathophysiological process of acne according to all targets and links of the acne, thereby achieving the triple effects of controlling oil, removing acne and repairing acne marks.

Description

Acne-removing composition containing saw palmetto essential oil and preparation method thereof

Technical Field

The invention relates to an acne-removing composition containing sawpalmetto essential oil and a preparation method thereof, belonging to the technical field of cosmetics.

Background

Acne, also known as whelk, pimple and comedo, is a common chronic disease and frequently occurs disease in dermatology. Statistics show that 95% of men and 85% of women in adolescence suffer from acne of different degrees. The main clinical manifestations of acne are blackhead, whitehead, inflammatory papules, pustules, nodules, cysts; pigmentation, large pores and even scar-like lesions are easy to form. The pathogenesis of acne is complex, including: excessive androgen secretion, excessive local androgen receptor expression, hypersecretion of sebaceous glands, hyperkeratosis of hair follicles, and acneiform c infection. After puberty, the level of male hormone in human body, especially testosterone, is rapidly increased, the sebaceous gland development is promoted, and a large amount of sebum is produced; meanwhile, abnormal keratinization of the pilosebaceous canal causes the canal to be blocked and sebum is discharged to be obstructed, and micro acne is formed; the proliferation of a number of microorganisms in the hair follicle, particularly propionibacterium acnes, and the lipase produced by propionibacterium acnes breaks down sebum to produce free fatty acids, chemotactic inflammatory cells and mediators, and ultimately induce and exacerbate the inflammatory response.

The number of acne-removing products in the market is not enough, but most of the ointment and the medicinal cream can cause stimulation and damage to the skin to different degrees and have certain side effects. In addition, the product added with hormone is easy to rebound to cause the acne to recur; the traditional Chinese medicine for treating acne has many traditional Chinese medicine products, complex components and unstable quality.

Saw palmetto (Saw palmetto), also known as sabal palm, is a plant of the palmaceae family native to the south east coast of the America. In 1908, saw palmetto fruit was loaded into the United states pharmacopoeia, which was widely used in European countries in 1950, and subsequently loaded into the British pharmacopoeia, European pharmacopoeia, Martindale pharmacopoeia, and the like. Modern research finds that: saw palmetto has good safety, is a botanical drug with excellent treatment effect on prostatic hyperplasia and urinary system diseases, is one of natural drugs which are popular in the European and American markets at present, and is widely applied to clinic. The saw palmetto was found to have the following effects: (1) saw palmetto can effectively inhibit the activity of I-type and II-type 5 alpha-reductase, reduce the transformation of testosterone to Dihydrotestosterone (DHT) in prostate tissue, and thus inhibit prostate hyperplasia; and competitively inhibits the binding of DHT to androgen receptors in the prostate. (2) Serenoa repens can interfere with the production of inflammatory mediators, such as prostaglandins, and the synthesis of the 5-lipoxygenase metabolite leukotriene B4(Leukotriene B4), thereby exerting an anti-inflammatory effect; sophie et al found that saw palmetto inhibited pro-inflammatory cytokines in prostate, significantly reduced the expression of interleukin-17 (interleukin 17, IL-17) and interleukin-6 (interleukin 6, IL-6), and thereby inhibited prostate hyperplasia. (3) Saw palmetto inhibits alpha 1-adrenergic receptors of prostate and bladder in a non-competitive way by improving the fibrous structure of bladder smooth muscle, reduces the contraction of bladder smooth muscle and effectively improves the symptom of lower urinary tract.

At present, the saw palmetto is reported in domestic and foreign documents to be mainly used for treating benign prostatic hyperplasia, and the using method is mainly oral administration. Through literature search, no anti-acne product and technology using saw palmetto as a main drug effect component is reported at home and abroad up to now. The invention discovers for the first time that the saw palmetto extract can be used for treating acne by local skin and has the effect of preventing acne recurrence; has wide application prospect in treating indications and medication method.

Disclosure of Invention

The invention relates to an acne removing composition containing sawpalmetto essential oil, wherein an acne removing product is prepared from the following raw materials in parts by weight: 0.05-0.10 part of saw palmetto essential oil, 0.01-0.05 part of angelica ferulic acid, 0.50-2.00 parts of pueraria isoflavone, 0.50-3.00 parts of wheat protein extract, 1.00-10.00 parts of salicylic acid, 1.00-5.00 parts of nicotinamide, 0.50-5.00 parts of citric acid, 0.10-3.00 parts of zinc gluconate, 0.50-2.00 parts of aloe vera freeze-dried powder, 0.05-1.00 part of patchouli essential oil, 0.01-0.10 part of chamomile essential oil, 0.50-3.00 parts of allantoin, 0.20-0.50 part of glycyrrhizic acid glass, 0.10-0.50 part of dipotassium, 1.00-8.00 parts of plant antibacterial component combination and 0.50-1.00 part of arbutin.

Preferably, the plant antibacterial ingredient combination consists of eugenol and cineole, and the mass ratio of the eugenol to the cineole is 1: 1.

The composition is prepared into an ointment, a cream, a lotion, a mask or a facial cleanser together with other auxiliary materials acceptable to human bodies.

Preferably, the anti-acne composition containing the serenoa repens essential oil is prepared into cream, and specifically comprises the following steps:

(1) dispersing 0.016kg of xanthan gum and 0.1-0.2 kg of polyacrylate cross-linked polymer-6 by using 0.8-1.2 kg of glycerol and 0.5-0.7 kg of 1, 3-butanediol, adding into 12-13 kg of purified water, after complete dissolution, adding 0.07-0.09 kg of aloe freeze-dried powder and 2-3 kg of 1, 3-butanediol, stirring and dissolving, heating to 70-75 ℃ after the solution is completely dissolved to be semitransparent mucus, controlling the stirring speed at 20rpm, and avoiding a large amount of bubbles from generating to obtain phase A.

(2) Transferring 0.5-0.6 kg of hexadecanol, 0.1-0.3 kg of SQE21 emulsifier, 0.3-0.5 kg of dimethyl silicone oil, 0.9-1.1 kg of caprylic/capric triglyceride and 0.5-0.7 kg of ethylhexyl palmitate into an oil phase pot, heating to 75 ℃, and stirring while heating; the solution is white emulsion after being fully dissolved, and the heating time is controlled within 20 minutes to obtain a phase B.

(3) Slowly adding the phase B into the phase A at a constant speed under rapid stirring, continuously stirring for 15 minutes after homogenization, stirring at a speed of 20rpm, cooling to 40 ℃, adding accurately weighed 0.9kg of phase C raw material, and continuously stirring for 10 minutes after adding; stirring at low speed, filtering, and discharging to obtain the final product.

The phase C is a mixture obtained by mixing saw palmetto essential oil, Chinese angelica ferulic acid, pueraria isoflavone, wheat protein extract, salicylic acid, nicotinamide, citric acid, zinc gluconate, aloe barbadensis freeze-dried powder, patchouli essential oil, chamomile essential oil, allantoin, hyaluronic acid, dipotassium glycyrrhizinate, plant antibacterial component combination and arbutin according to a proportion.

The saw palmetto essential oil is prepared by extracting fruits by a supercritical method, and is rich in various fatty acids and volatile oil; mainly comprises saturated and unsaturated fatty acids such as oleic acid, lauric acid, myristic acid, palmitic acid, linoleic acid, stearic acid, linolenic acid, and the like.

The kudzu root is an ancient Chinese medicinal material and has important medicinal value; the isoflavone compound is rich in isoflavone compounds, and researches show that the isoflavone compound has wide application values in the aspects of expanding blood vessels, resisting aging, resisting thrombus, reducing blood fat and blood pressure, enhancing memory, enhancing immunity, having estrogen-like effect and the like. The pueraria isoflavone of the invention is a main effective component in pueraria and comprises the following components: puerarin, 3-hydroxy puerarin, 3-methoxy puerarin, xyloside, daidzein, daidzin, formononetin, genistin, etc., wherein puerarin accounts for the main component. The radix Puerariae isoflavone can improve blood flow velocity, dilate blood vessel, relieve vasospasm, inhibit platelet aggregation, repair endothelial cells, increase PGl2/TXA2 level, and reduce catecholamine generation, thereby reducing blood viscosity and inhibiting thrombosis. Meanwhile, puerarin can obviously inhibit 5-HT release in thrombocyte induced by prothrombin, has inhibiting effect on the aggregation of erythrocyte and thrombocyte, prolongs the time of in vivo thrombosis and the time of blood coagulation, and has obvious antithrombotic and anticoagulant effects. The chemical structure of the pueraria isoflavone is a bisphenol structure, and is a phytoestrogen which is most similar to the estrogen secreted by a human body on the molecular structure. On one hand, the compound can act on an estrogen receptor in vivo and produce an effect, and the effect is mild; on the other hand, the dynamic balance of estrogen in the body can be maintained: when the estrogen is deficient in the body, the pueraria isoflavone can play a role in supplementing the estrogen and has no obvious influence on the normal estrogen level; when the estrogen level in the body is too high, the pueraria isoflavone can prevent the estrogen from acting on a target organ too much, so that the estrogen level is kept relatively balanced; research shows that the pueraria isoflavone can improve hypofunction of ovaries caused by the fact that the estrogen level in the bodies of the aged rats is reduced to enhance the lipid peroxidation and reduce the activity of free radical scavenging enzymes. The mechanism may be: the pueraria isoflavone acts on the hypothalamus-pituitary-ovary axis of an aging rat to regulate the estrogen level in vivo, thereby maintaining the balance of oxidation and oxidation resistance of an organism. At present, pueraria isoflavone is often used as an estrogen replacement therapy in clinic to treat a series of diseases caused by the reduction of the estrogen level in the female in menopause.

The angelica ferulic acid is a monomer component of angelica, and the angelica sodium ferulate is sodium salt of ferulic acid; the sodium ferulate has antiinflammatory and antioxidant effects; it can directly resist the action of inflammatory mediators, reduce the release amount of prostaglandin E in inflammatory tissues, and inhibit inflammatory exudation, thereby inhibiting the subsequent inflammatory reaction.

The invention has the beneficial effects that:

the acne-removing composition disclosed by the invention is applied to the concepts of dialectical treatment and comprehensive treatment in the traditional Chinese medicine, and various plant extracts are adopted, so that the pathophysiological process of acne is effectively blocked aiming at all targets and links of acne attack, and thus the triple effects of controlling oil, removing acne and repairing acne marks are achieved. The salicylic acid, the citric acid and the zinc gluconate dissolve sebum accumulated in hair follicles; saw palmetto essential oil blocks local skin testosterone receptors and inhibits sebaceous gland secretion; salicylic acid, citric acid, radix Puerariae isoflavone, radix Angelicae sinensis ferulic acid, and dipotassium glycyrrhizinate for inhibiting hair follicle hyperkeratosis; salicylic acid and citric acid inhibit the growth of propionibacterium acnes; the nicotinamide and the aloe vera freeze-dried powder can preserve moisture and supplement local skin nutrient components; salicylic acid, nicotinamide, citric acid, zinc gluconate, aloe barbadensis freeze-dried powder, arbutin and patchouli essential oil relieve skin and repair acne marks; the pueraria isoflavone and the angelica ferulic acid dredge blood and lymph circulation of locally damaged skin; the plant antibacterial components eugenol and eucalyptol are effective in inhibiting the growth of Propionibacterium acnes.

The formula adopts the plant fine extract, so that the side effects, the unpleasant odor and the uncomfortable skin feeling of the traditional Chinese medicine impurities are overcome; it contains no antibiotic, hormone and chemical agent, and can be used for a long time without side effect. Can be used for development and production of cosmetics and medicines; can also be made into ointment, cream, milky lotion, facial mask, facial cleanser, etc.; has wide market prospect.

Description of the drawings:

FIG. 1 is a graph comparing the therapeutic effects of typical cases in example 1;

FIG. 2 is a graph comparing the therapeutic effects of typical cases in example 2;

FIG. 3 is a graph showing the comparison of the therapeutic effects of the typical cases in example 3.

Detailed Description

The present invention will be described in further detail with reference to specific examples, but the scope of the present invention is not limited to the examples.

The acne-removing composition disclosed by the invention applies the concepts of dialectical treatment and comprehensive treatment in the traditional Chinese medicine, adopts various plant extracts, and aims at all targets and links related to acne pathogenesis: excessive androgen secretion or/and over-expression of testosterone receptor; sebaceous gland exuberance and sebum accumulation in hair follicle; hyperkeratosis of hair follicle epithelium and poor excretion of sebum in hair follicle; fourthly, infection of propionibacterium acnes in hair follicles; local blood and lymph reflux disorder, hemoglobin and pigmentation; sixthly, local inflammatory mediator is excessively released; effectively blocks the pathophysiology process, thereby achieving the triple effects of controlling oil, removing acne and repairing acne marks.

The acne clinical manifestation severity classification standard is as follows:

mild (grade i): acne is a major skin lesion with small amounts of papules and pustules, with a total lesion count of less than 30.

Moderate (including II and III)

(stage II): has acne, moderate papules and pustules, and 31-50 total lesions.

(stage III): a large number of papules and pustules are occasionally associated with large inflammatory lesions, which are widely distributed. The total number of the lesions is 51-100, and the number of the nodules is less than 3.

Severe (grade iv): nodular/cystic or polymeric acne, most of which has pain and forms cysts, the number of focuses is more than 100; the number of nodules/cysts is more than 3.

The exclusion criteria are combined with the inclusion and exclusion criteria of the cosmetic contact dermatitis diagnostic criteria and the treatment principles thereof.

Secondly, the evaluation standard of the curative effect is as follows:

the curative effect index is as follows: (total skin loss before use-total skin loss after use)/total skin loss before use × 100%. .

Effective rate (number of cured people plus number of effective people)/total number of people x 100%.

The curative effect index is more than or equal to 90 percent.

The effective rate is more than or equal to 60 percent and the curative effect index is less than or equal to 90 percent.

The effective index is more than or equal to 20 percent and less than or equal to 60 percent.

Efficacy index < 20%.

Example 1

The implementation further illustrates the acne removing efficacy of the acne removing composition through clinical experiments.

800 patients clinically diagnosed with acne were collected, wherein 420 male patients and 380 female patients were aged 18-30 years; patients were divided into 8 groups of 100 people each, with the acne being graded (similar numbers and proportions of mild, moderate and severe).

TABLE 1

The basic formulation in table 1 is: 2.00 parts of wheat protein extract, 5.00 parts of salicylic acid, 3.00 parts of nicotinamide, 2.00 parts of citric acid, 2.00 parts of zinc gluconate, 1.00 part of aloe vera freeze-dried powder, 0.05 part of patchouli essential oil, 0.01 part of chamomile essential oil, 2.00 parts of allantoin, 0.20 part of hyaluronic acid, 0.50 part of dipotassium glycyrrhizinate, 4.00 parts of plant antibiotic composition and 0.80 part of arbutin.

The formula is processed by Yunnan Bonielan biological technology limited company to be made into cream, and the cream is delivered to the 8 groups of patients after being checked to be qualified; the using method comprises the following steps: applying on affected part, massaging gently for 2-3 times per day for four weeks, observing and collecting clinical results, and collating and analyzing data as shown in Table 2.

TABLE 2

Group of	Invalid number of people (human)	Number of valid persons (human)	Number of effective people (human)	The number of cured people (human)	High efficiency
						1	20	22	35	23	58.00％
2	2	4	43	51	94.00％
						3	2	3	42	53	95.00％
4	1	2	41	56	97.00％
						5	12	23	34	31	65.00％
6	10	16	39	35	74.00％
						7	14	16	36	34	70.00％
8	17	20	31	32	63.00％

As can be seen from the results in table 2, the saw palmetto essential oil, the angelica ferulic acid and the pueraria isoflavone can be added according to a specific proportion to realize the best acne removing effect under the condition of the same basic formula; if only one or two of the above ingredients are selected, the effect is improved but the best effect is not achieved compared with the basic formula.

Example 2

In order to further illustrate that the saw palmetto essential oil, the angelica ferulic acid and the pueraria isoflavone have the acne-removing effect, animal experiments further verify that the saw palmetto essential oil, the angelica ferulic acid and the pueraria isoflavone have the acne-removing effect.

This example used a conventional method (Kligman method, a standard rabbit ear model established by the American dermatological society in 1989) to establish a rabbit ear acne model. The method specifically comprises the following steps: coating coal tar for 2cm × 2cm at the opening of ear canal at the inner side of external auditory canal of male rabbit for 2 weeks, 0.5ml each time, 1 time per day, and making it into experimental acne model; thereafter, acne was topically applied 2 times a day for a total of 4 weeks with cream 0.25ml, and the number of comedones was observed again to verify the therapeutic effect of the drug.

The rabbit ear acne is successfully established according to the conventional method, and 10 rabbits with moderate and severe acne are selected as a group; the experimental animals are divided into: the basic formula group, experimental group 1 (basic formula + saw palmetto essential oil + angelica ferulic acid + pueraria isoflavone), experimental group 2 (basic formula + saw palmetto essential oil), experimental group 3 (basic formula + angelica ferulic acid), experimental group 4 (basic formula + pueraria isoflavone), each group had 20 (n ═ 20), the time of ointment application was four weeks, and the experimental results are shown in table 3:

TABLE 3

The experimental results were analyzed by X + -s, and the P was <0.01 in the experimental group compared with the basic formula group, and the comparison between the two groups was statistically different.

As can be seen from table 3: the basic formula is added with saw palmetto essential oil, angelica ferulic acid and pueraria isoflavone, and the treatment effect on the acne is better than that of other groups.

Analysis of the mechanisms of acne formation and treatment found that: the saw palmetto extract is locally used, so that the local skin androgen receptor and inflammatory reaction can be effectively inhibited, the secretion quantity and inflammatory reaction of local skin hair follicle endothelial sebaceous glands can be effectively reduced, the local hair follicle keratinization degree is reduced, and the clinical treatment effect of acne is improved. Local inflammation of hair follicles of acne causes local capillary constriction and blood circulation disturbance, and local red swelling and blood stasis; the saw palmetto achieves the effect of dredging local blood circulation by expanding local capillary vessels. The Serenoa repens extract is mainly fatty acid, and has high skin absorption rate and strong skin permeability when being used topically. The composition of the invention is added with the component for enhancing the skin permeability, so that the saw palmetto can effectively enter the dermis layer of the skin and fully exert the pharmacological effect thereof. At present, the domestic and foreign documents report that saw palmetto is mainly used for treating benign prostatic hyperplasia, and the using method and oral administration are the main; the invention discovers for the first time that the saw palmetto extract can be used for treating acne by local skin application and has the effect of preventing acne recurrence.

The factors such as sebaceous gland aggregation and Propionibacterium acnes infection cause aseptic and bacterial inflammatory reaction of the lesion local hair follicle, factors such as local inflammatory mediators and prostaglandin E aggravate local inflammatory reaction, multiple injuries of skin tissues are caused, and the factors are also one of the main reasons for forming scars locally. The angelica ferulic acid selected by the invention has pharmacological actions of resisting inflammation, resisting oxidation, inhibiting amino acid metabolism and the like, can directly resist the action of inflammatory mediators, reduces the release amount of prostaglandin E in inflammatory tissues, and inhibits inflammatory exudation, thereby inhibiting the subsequent inflammatory reaction.

Increased androgen levels or/and decreased estrogen levels in the body are one of the major pathogenesis of acne. The pueraria isoflavone is locally used, so that the local skin estrogen concentration can be increased, and the excessive sebaceous gland secretion caused by the overhigh local skin androgen level can be effectively resisted, so that the generation and the recurrence of the acne can be effectively inhibited from the root. The pueraria isoflavone can accelerate blood flow speed of local skin of acne, dilate capillary vessel, relieve vasospasm, inhibit platelet aggregation, repair endothelial cells, improve PGl2/TXA2 level and reduce catecholamine generation, thereby reducing blood viscosity, inhibiting thrombosis, accelerating local inflammation absorption, relieving tissue edema and eliminating local skin acne mark and pigmentation.

Example 3

The acne removing composition containing the serenoa repens essential oil is prepared from the following raw materials in parts by weight: 0.10 part of saw palmetto essential oil, 0.02 part of angelica ferulic acid, 0.60 part of pueraria isoflavone, 0.50 part of wheat protein extract, 3.00 parts of salicylic acid, 1.00 part of nicotinamide, 0.20 part of citric acid, 0.10 part of zinc gluconate, 3.00 parts of aloe vera essence freeze-dried powder, 0.05 part of patchouli essential oil, 0.01 part of chamomile essential oil, 3.00 parts of allantoin, 0.20 part of hyaluronic acid, 0.50 part of dipotassium glycyrrhizinate, 1.00 part of plant antibiotic composition and 0.50 part of arbutin.

The formula is prepared into cream by the following method, wherein the phase C is the composition:

(1) dispersing 0.016kg of xanthan gum and 0.16kg of polyacrylate crosslinked polymer-6 by using 1kg of glycerol and 0.6kg of 1, 3-butanediol, adding into 12.62kg of purified water, after complete dissolution, adding 0.08kg of aloe freeze-dried powder and 2.12kg of 1, 3-butanediol, stirring and dissolving, heating to 75 ℃ after the solution is completely dissolved and is semitransparent mucus, controlling the stirring speed to be 20rpm, and avoiding generation of a large amount of bubbles to obtain phase A.

(2) Transferring 0.54kg of cetostearyl alcohol, 0.2kg of SQE21 emulsifier, 0.4kg of dimethicone, 1kg of caprylic/capric triglyceride, and 0.6kg of C24 (ethylhexyl palmitate) into an oil phase pot, heating to 75 deg.C, and stirring while heating; the solution is white emulsion after being fully dissolved, and the heating time is controlled within 20 minutes to obtain a phase B.

(3) Slowly adding the phase B into the phase A at a constant speed under rapid stirring, continuously stirring for 15 minutes after homogenization, stirring at a speed of 20rpm, cooling to 40 ℃, accurately weighing 0.9kg of phase C raw material, adding, and continuously stirring for 10 minutes; stirring at low speed, filtering, and discharging to obtain the final product.

The using method comprises the following steps: applying on affected part, massaging gently for 2-3 times per day for three weeks, observing and collecting clinical results, and collecting and analyzing data.

In the embodiment, 100 patients clinically diagnosed as acne are randomly collected, wherein 55 male patients and 45 female patients are aged between 18 and 30 years; the effective rate of the acne-removing composition in the embodiment is 98%, wherein the effective rate is (the number of cured people plus the number of effective people)/the total number of people multiplied by 100%.

Typical case 1

Patient, female, 19 years old, long acne 4 years, oily skin. The acne is a severe mixed type acne with a large number of acne marks and pigmentation, and the acne is treated for a plurality of times in a beauty parlor before, and is often repeated and can not be cured all the time. The cream with the formula is applied to the affected part three times a day after 3 months in 2018, and the acne completely disappears and acne marks and pigmentation are not existed after 2 months of treatment, as shown in figure 1.

Example 4

The acne removing composition containing the serenoa repens essential oil is prepared from the following raw materials in parts by weight: 0.08 part of saw palmetto essential oil, 0.04 part of angelica ferulic acid, 1.50 parts of pueraria isoflavone, 3.00 parts of wheat protein extract, 1.00 part of salicylic acid, 5.00 parts of nicotinamide, 5.00 parts of citric acid, 3.00 parts of zinc gluconate, 0.50 part of aloe barbadensis freeze-dried powder, 1.00 part of patchouli essential oil, 0.01 part of chamomile essential oil, 0.50 part of allantoin, 0.20 part of hyaluronic acid, 0.50 part of dipotassium glycyrrhizinate, 8.00 parts of plant antibiotic composition and 1.00 part of arbutin.

The formula is prepared into cream by the following method, wherein the phase C is the composition:

(1) dispersing 0.016kg of xanthan gum and 0.16kg of polyacrylate crosslinked polymer-6 by using 1kg of glycerol and 0.6kg of 1, 3-butanediol, adding into 12.62kg of purified water, after complete dissolution, adding 0.08kg of aloe powder and 2.12kg of 1, 3-butanediol, stirring and dissolving, heating to 75 ℃ after the solution is completely dissolved and is semitransparent mucus, controlling the stirring speed to be 20rpm, and avoiding a large amount of bubbles from generating to obtain phase A.

(2) Transferring 0.54kg of cetostearyl alcohol, 0.2kg of SQE21 emulsifier, 0.4kg of dimethicone, 1kg of caprylic/capric triglyceride, and 0.6kg of C24 (ethylhexyl palmitate) into an oil phase pot, heating to 75 deg.C, and stirring while heating; the solution is white emulsion after being fully dissolved, and the heating time is controlled within 20 minutes to obtain a phase B.

(3) Slowly adding the phase B into the phase A at a constant speed under rapid stirring, continuously stirring for 15 minutes after homogenization, stirring at a speed of 20rpm, cooling to 40 ℃, accurately weighing 0.9kg of phase C raw material, adding, and continuously stirring for 10 minutes; stirring at low speed, filtering, and discharging to obtain the final product.

The using method comprises the following steps: applying on affected part, massaging gently for 2-3 times per day for three weeks, observing and collecting clinical results, and collecting and analyzing data.

In the embodiment, 100 patients clinically diagnosed as acne are randomly collected, wherein 53 male patients and 57 female patients are aged between 18 and 30 years, and the effective rate of the acne removing composition is 95%.

Typical case 2

The patient, female, is 22 years old, has 6 years of acne growing time, and belongs to severe mixed acne and oily skin. Various acne removing products on the market are used before, so that the acne removing products are good in time and bad in time and cannot be completely cured all the time; particularly, the food is aggravated after being eaten with spicy stimulation, thereby seriously influencing normal work and study and generating serious psychological burden. The cream with the formula is applied to the affected part three times a day in 5 months in 2019, and after 1 month, the acne completely disappears and only a little acne mark is left as shown in figure 2 after the affected part is added with the conditioning diet.

Example 5

The acne removing composition containing the serenoa repens essential oil is prepared from the following raw materials in parts by weight: 0.05 part of saw palmetto essential oil, 0.03 part of angelica ferulic acid, 1.80 parts of pueraria isoflavone, 1.0 part of wheat protein extract, 10.0 parts of salicylic acid, 4.00 parts of nicotinamide, 3.00 parts of citric acid, 1.00 parts of zinc gluconate, 2.00 parts of aloe vera freeze-dried powder, 0.80 part of patchouli essential oil, 0.01 part of chamomile essential oil, 1.00 part of allantoin, 0.20 part of hyaluronic acid, 0.50 part of dipotassium glycyrrhizinate, 6.00 parts of plant antibiotic composition and 0.60 part of arbutin.

The formula is prepared into cream by the following method, wherein the phase C is the composition:

(1) dispersing 0.016kg of xanthan gum and 0.16kg of polyacrylate crosslinked polymer-6 by using 1kg of glycerol and 0.6kg of 1, 3-butanediol, adding into 12.62kg of purified water, after complete dissolution, adding 0.08kg of aloe powder and 2.12kg of 1, 3-butanediol, stirring and dissolving, heating to 75 ℃ after the solution is completely dissolved and is semitransparent mucus, controlling the stirring speed to be 20rpm, and avoiding a large amount of bubbles from generating to obtain phase A.

(2) Transferring 0.54kg of cetostearyl alcohol, 0.2kg of SQE21 emulsifier, 0.4kg of dimethicone, 1kg of caprylic/capric triglyceride, and 0.6kg of C24 (ethylhexyl palmitate) into an oil phase pot, heating to 75 deg.C, and stirring while heating; the solution is white emulsion after being fully dissolved, and the heating time is controlled within 20 minutes to obtain a phase B.

(3) Slowly adding the phase B into the phase A at a constant speed under rapid stirring, continuously stirring for 15 minutes after homogenization, stirring at a speed of 20rpm, cooling to 40 ℃, accurately weighing 0.9kg of phase C raw material, adding, and continuously stirring for 10 minutes; stirring at low speed, filtering, and discharging to obtain the final product.

The using method comprises the following steps: applying on affected part, massaging gently for 2-3 times per day for three weeks, observing and collecting clinical results, and collecting and analyzing data.

In the embodiment, 100 patients clinically diagnosed as acne are randomly collected, wherein 50 male patients and 50 female patients are aged between 18 and 30 years, and the effective rate of the acne removing composition is 96%.

Typical case 3

Female patients, 16 years old, have 2 years of acne growing time, have neutral skin, belong to moderate mixed acne, and mainly have a large number of closed acnes. The repeated use of a plurality of acne removing products on the market has no obvious effect, and particularly, the acne is aggravated during the menstruation. Severely affecting learning and even producing mild depressive symptoms. The cream prepared by the formula is applied to the affected part three times a day after 5 months in 2019, and the acne completely disappears after the affected part is continuously used for one month. After that, one or two acne cream occasionally grows, and the acne cream completely disappears after 2-3 days.

The product prepared from the acne-removing composition containing the serenoa repens essential oil is sent to a Ningbo entry-exit inspection and quarantine bureau inspection and quarantine technical center for inspection, and the color and the state of the product are as follows: milky white cream, the results of the sanitary chemical examination are shown in Table 4.

TABLE 4 sanitary chemistry test results

Claims (4)

1. An acne-removing composition containing sawpalmetto essential oil is characterized in that: the acne removing product is prepared from the following raw materials in parts by weight: 0.05-0.10 part of saw palmetto essential oil, 0.01-0.05 part of angelica ferulic acid, 0.50-2.00 parts of pueraria isoflavone, 0.50-3.00 parts of wheat protein extract, 1.00-10.00 parts of salicylic acid, 1.00-5.00 parts of nicotinamide, 0.50-5.00 parts of citric acid, 0.10-3.00 parts of zinc gluconate, 0.50-2.00 parts of aloe vera freeze-dried powder, 0.05-1.00 part of patchouli essential oil, 0.01-0.10 part of chamomile essential oil, 0.50-3.00 parts of allantoin, 0.20-0.50 part of glycyrrhizic acid glass, 0.10-0.50 part of dipotassium, 1.00-8.00 parts of plant antibacterial component combination and 0.50-1.00 part of arbutin.

2. The anti-acne composition containing serenoa repens essential oil according to claim 1, characterized in that: the plant antibacterial component composition consists of eugenol and cineole, wherein the mass ratio of the eugenol to the cineole is 1: 1.

3. The anti-acne composition containing serenoa repens essential oil according to claim 1, characterized in that: the composition is prepared into an ointment, a cream, a milky lotion, a mask or a facial cleanser together with other human acceptable auxiliary materials.

4. The method for preparing the anti-acne composition containing the serenoa repens essential oil in claim 3 is characterized in that: the acne-removing composition is prepared into cream, and specifically comprises the following steps:

(1) dispersing 0.016kg of xanthan gum and 0.1-0.2 kg of polyacrylate cross-linked polymer-6 by using 0.8-1.2 kg of glycerol and 0.5-0.7 kg of 1, 3-butanediol, adding into 12-13 kg of purified water, after complete dissolution, adding 0.07-0.09 kg of aloe freeze-dried powder and 2-3 kg of 1, 3-butanediol, stirring and dissolving, heating to 70-75 ℃ after complete dissolution and the solution is semitransparent mucus, controlling the stirring speed at 20rpm, and avoiding generation of a large amount of bubbles to obtain a phase A;

(2) transferring 0.5-0.6 kg of hexadecanol, 0.1-0.3 kg of SQE21 emulsifier, 0.3-0.5 kg of dimethyl silicone oil, 0.9-1.1 kg of caprylic/capric triglyceride and 0.5-0.7 kg of ethylhexyl palmitate into an oil phase pot, heating to 75 ℃, and stirring while heating; fully dissolving to obtain white emulsion, and heating for 20 min to obtain phase B;

(3) slowly adding the phase B into the phase A at a constant speed under rapid stirring, continuously stirring for 15 minutes after homogenization, stirring at a speed of 20rpm, cooling to 40 ℃, adding accurately weighed 0.9kg of phase C raw material, and continuously stirring for 10 minutes after adding; stirring at low speed, filtering, and discharging to obtain acne removing cream containing saw palmetto essential oil;

the phase C is a mixture obtained by mixing saw palmetto essential oil, Chinese angelica ferulic acid, pueraria isoflavone, wheat protein extract, salicylic acid, nicotinamide, citric acid, zinc gluconate, aloe barbadensis freeze-dried powder, patchouli essential oil, chamomile essential oil, allantoin, hyaluronic acid, dipotassium glycyrrhizinate, plant antibacterial component combination and arbutin according to a proportion.

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