CN106309156A - Ferulic acid acne fading solution and preparation method thereof - Google Patents
Ferulic acid acne fading solution and preparation method thereof Download PDFInfo
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- CN106309156A CN106309156A CN201610929148.2A CN201610929148A CN106309156A CN 106309156 A CN106309156 A CN 106309156A CN 201610929148 A CN201610929148 A CN 201610929148A CN 106309156 A CN106309156 A CN 106309156A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention provides a ferulic acid acne fading solution and a preparation method thereof. The ferulic acid acne fading solution is mainly prepared from the following components in parts by weight: 1 to 2 parts of ferulic acid, 0.15 to 10 parts of sodium hyaluronate, 2 to 12 parts of mycose, 1 to 10 parts of nicotinamide, 3 to 12 parts of glycerinum, 0.4 to 5 parts of allantoin, 1 to 9 parts of hydroxyethylcellouse, 0.5 to 12 parts of D-panthenol and 20 to 30 parts of water. The ferulic acid acne fading solution provided by the invention has an obvious acne fading effect, becomes effective quickly, and can quickly promote the healing of skin suffering from acne.
Description
Technical field
The present invention relates to cosmetic technical field, especially relate to a kind of ferulic acid and remove skin ulcer water and preparation method thereof.
Background technology
Acne is that one betides pilosebaceous chronic inflammation disease, takes place mostly in head and chest and back, relatively
Involve extremity less.Generally its course of disease is sustainable for many years.There are some researches show that U.S. 12-24 year crowd's acne prevalence is 85%.Separately
Having been reported that Some Domestic area university students's acne prevalence is up to 85.3%, existing prevalence is 36.4%.Postpubescence acne is then
Based on women, 28～37 years old 1 levels in female patients with acne prevalence 23%～26%, and 42～52 years old women also have the trouble of 3%～5%
Sick rate.Along with raising and the change of living habit of people's living standard, acne is increasingly subject to people's attention.Partly
District's Dermatology Outpatient Department survey result shows, in common discosmetic dermatosis, acne ranks the first.
The pathogenesis of acne is the most not yet fully apparent from, but most scholar is considered multifactor coefficient result,
Generally and androgen, propionibacterium acnes propagation, the cured secretion of skin, the dyskeratosis of pilosebaceous duct, immunne response, psychology
And the factor such as heredity is relevant.The clinical Therapeutic Principle for acne is the link as much as possible acting on pathogenesis of acne, including
Reduce and suppression sebum secretion, minimizing hair follicle block, suppress or kill propionibacterium acnes, control inflammation, and avoid or subtract
Few cicatrization etc..In for, severe acne, generally use the principle of Systemic administration, then can local application for mild acne.
The medicines such as current clinical treatment acne common antibiotics class, retinoid, androgen antagonist, and multiple physical therapy modalities.
But there is the shortcomings such as the length course for the treatment of, untoward reaction recurrence more, easy and part therapy somewhat expensive in above-mentioned therapy.
The Natural antioxidant that ferulic acid is well recognized as, is also the anti-cancer material of international cognition in recent years, causes common people to gaze at.
Ferulic acid has good antioxidant activity, has hydrogen peroxide, superoxide radical, hydroxy radical, peroxynitrite strongly
Scavenging action, and physiological function can be regulated, suppression produces the enzyme of free radical, increases the activity removing free radical enzyme.It is reported,
Ferulic acid can be greatly increased the activity of glutathione S-transferase and quinone reductase, suppresses tyrosinase activity, and can be with film phosphorus
Acyl ethamine combines, and protecting film fat is not attacked by free radical.The reports such as Kayahara etc. and Kawabatta, ferulic acid can be big
Big glutathione S-transferase and the activity of quinone reductase of increasing, suppression tyrosinase activity.Experimentation also finds, ferulic acid
The peroxide produced in energy protective, the cell injury that particularly hydroxy radical, nitric oxide cause.And, with other phenol
Class material is compared, and ferulic acid has two advantages: one is that its antioxidant activity is strong.Antioxidation in lecithin-liposome system
In activity, same to gallic acid, propylgallate, caffeic acid, enidin, delphinidin, catechin, epicatechin, rutin, Mongolian oak
Pi Su compares, and the rejection ability that hydroperoxides are produced by ferulic acid is the strongest.Another advantage of ferulic acid is the most stable, its pH
Stability is significantly stronger than chlorogenic acid, caffeic acid and gallic acid.
Harmful substance and other skin injurys in extraneous ultraviolet, radiation, air can destroy keratodermatitis, make epidermis
Produce more free radical with hypodermal cell metabolism, destroy cell membrane further, cause water loss, aggravation fat secretion to be lost
Adjust, cause the inflammatory reaction of skin.Ferulic acid has strong anti-oxidative activity, can prevent cell by free radical in scavenger cell
The destruction of plasma membrane and the loss of cell moisture, reduce inflammation reaction.
Ferulic acid molecular weight 194.14, it has preferable Transdermal absorption performance.Wei Li etc. use Valia-Chien diffusion cell
With HPLC method, utilizing in vitro nude mice skin to be studied the Transdermal absorption of ferulic acid, result shows not add any rush saturating
In the case of agent, ferulic acid can fast strikethrough nude mice skin, this just explanation ferulic acid inherently have good Transdermal absorption function.
Exploitation to ferulic acid at present focus mostly at pure field of medicaments, are limited to whitening more in beauty and skin care field, dispel
Speckle effect, rarely has report about the product going acne.
In view of this, the special proposition present invention.
Summary of the invention
The first object of the present invention is to provide a kind of ferulic acid to go skin ulcer water, described ferulic acid to go the obvious acne of skin ulcer water
Disappear effect, and instant effect, can rapidly promote the healing of acne skin.
The second object of the present invention is the preparation method providing above-mentioned ferulic acid to remove skin ulcer water, described preparation method flow process
Simply, operate safety, easily promote.
In order to reach above technique effect, the invention provides techniques below scheme:
A kind of ferulic acid removes skin ulcer water, is mainly made up of following component:
By weight, ferulic acid 1～2 parts, hyaluronate sodium 0.15～10 parts, trehalose 2～12 parts, nicotiamide 1～10
Part, glycerol 3～12 parts, allantoin 0.4～5 parts, hyetellose 1～9 parts, D-panthenol 0.5～12 parts, water 20-30 part.
Existing ferulyolated cosmetic, is all with whitening, speckle dispelling as primary efficacy, and ferulic acid is used for acne by the present invention
Treatment, formulated ferulic acid goes skin ulcer water to have effect that antiinflammatory is antibacterial, promotes the healing of acne skin.
Wherein, hyaluronate sodium, glycerol are wetting agent；Trehalose, nicotiamide are skin mucosa protective agent；Allantoin is glutinous
Film healing agent；D-panthenol is skin-nourishing supplement.After above component and ferulic acid combine, by inhibiting bacteria and diminishing inflammation, skin repair,
Skin care trilogy thoroughly eliminates acne.
Through statistics, the ferulic acid of the present invention goes the skin ulcer water extinction rate to acne in a week can reach more than 96.7%；And
And clinical cure rate reaches more than 98%.
The present invention goes skin ulcer water applicating method unrestricted, the most suitable, it is also possible to as MASQUE APAISANT HYDRATANT.
Above ferulic acid goes skin ulcer water to improve further:
Preferably, by weight, ferulic acid 1～2 parts, hyaluronate sodium 2～10 parts, trehalose 2～12 parts, nicotiamide 1
～10 parts, glycerol 3～8 parts, allantoin 0.4～2 parts, hyetellose 1～5 parts, D-panthenol 0.5～12 parts, water 20-25 part.
Preferably, by weight, ferulic acid 1～2 parts, hyaluronate sodium 5～10 parts, trehalose 5～12 parts, nicotiamide 5
～10 parts, glycerol 3～5 parts, allantoin 0.4～2 parts, hyetellose 1～5 parts, D-panthenol 8～12 parts, water 20-25 part.
Reduce allantoin, the proportion of glycerol, improve the proportion of other component such as hyaluronate sodium, trehalose, can improve
Product goes the speed that takes effect of skin ulcer.
It addition, the molecular weight of hyaluronate sodium is in (0.5～2.0) × 106In the range of be preferred, preferably 0.5 × 106, 0.7 ×
106, 1 × 106。
Preferably, aminoacid and/or vitamin E are also included；
Described aminoacid is preferably selected from lysine, glutamic acid, glycine one or more, preferably lysine, paddy ammonia
Acid, glycine mix with the weight ratio of 1:1-2:1-2.
Aminoacid can be as skin-nourishing supplement；Vitamin E both can be able to rise again anti-ageing as natural antiseptic agent
Old effect.
It is highly preferred that the addition of mentioned component is: by weight, also include lysine 0.5-5 part, glutamic acid 0.5-5
Part, glycine 0.5-5 part, vitamin E 0.15-5 part；
It is further preferred that lysine 2-5 part, glutamic acid 3-5 part, glycine 2-5 part, vitamin E 0.15-2 part.
Water used by the present invention is preferably deionized water, the water of preferably pH5.5-7.5, more preferably pH6-6.5.Select acidity
The water of partial neutral, both can play bactericidal action, can reduce again the zest to skin.
Preferably, also including penetrating agent, described penetrating agent is selected from oleic acid, menthol, azone, sodium laurylsulfate
Planting or multiple, preferably azone, sodium laurylsulfate mixes with the ratio of 1:2-4.
Penetrating agent is conducive to the percutaneous lipid barrier of product, promotes the absorption of effective ingredient, improves absorbance and sees
Effect speed.
The consumption of penetrating agent is preferably: by weight, penetrating agent 0.1-1.5 part, preferably 1-1.5 part.
Ferulic acid of the present invention goes the preparation method of skin ulcer water relatively simple:
All raw materials are mixed at 40-70 DEG C and get final product.
Wherein, in order to improve mixing efficiency, described mixing is further: be dissolved in sweet by hyaluronate sodium, allantoin mixing
In oil, then hyetellose, D-panthenol, trehalose, nicotiamide are mixed soluble in water, then above two solution is mixed,
Homogenizing.
If also one or more in aminoacid, vitamin E and penetrating agent, then mixed at all raw materials are at 40-70 DEG C
Add during conjunction.
To sum up, compared with prior art, invention achieves techniques below effect:
(1) work out a kind of ferulyolated cosmetic for acne and remove skin ulcer water.
(2) improve curative effect, and the speed that takes effect.
(3) preparation method is simple, safety.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme is clearly and completely described, but ability
Field technique personnel it will be appreciated that following described embodiment is a part of embodiment of the present invention rather than whole embodiments,
It is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under not making creative work premise, broadly falls into the model of present invention protection
Enclose.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument
Unreceipted production firm person, being can be by the commercially available conventional products bought and obtain.
Embodiment 1
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 1g, hyaluronate sodium (molecular weight 0.5 × 106) 10g, trehalose 2g, nicotiamide 10g, glycerol
3g, allantoin 5g, hyetellose 1g, D-panthenol 12g, deionized water (pH6.5) 20g.
Preparation: heat water to 40 ± 5 DEG C, is added thereto to other raw material, stirring and evenly mixing, cooling, to obtain final product.
Embodiment 2
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 2g, hyaluronate sodium (molecular weight 2 × 106) 0.15g, trehalose 12g, nicotiamide 1g, glycerol
12g, allantoin 0.4g, hyetellose 9g, D-panthenol 0.5g, deionized water (pH6.5) 30g.
Preparation: heat water to 70 ± 5 DEG C, is added thereto to other raw material, stirring and evenly mixing, cooling, to obtain final product.
Embodiment 3
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 2 parts, hyaluronate sodium (molecular weight 1 × 106) 2 parts, trehalose 12 parts, nicotiamide 10 parts, glycerol
8 parts, allantoin 2 parts, hyetellose 5 parts, D-panthenol 12 parts, deionized water (pH6.5) 25g.
Preparation:
Glycerol is heated to 50 ± 5 DEG C, is added thereto to hyaluronate sodium, allantoin, mixing.
Heat water to 50 ± 5 DEG C, be added thereto to other raw material, stirring and evenly mixing, then be added thereto to aforesaid glycerol
Solution, mixing, cool down and get final product.
Embodiment 4
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 1 part, hyaluronate sodium (molecular weight 0.7 × 106) 5 parts, trehalose 5 parts, nicotiamide 5 parts, glycerol
3 parts, allantoin 2 parts, hyetellose 5 parts, D-panthenol 8 parts, deionized water (pH6.5) 25g.
Preparation:
Glycerol is heated to 50 ± 5 DEG C, is added thereto to hyaluronate sodium, allantoin, mixing.
Heat water to 50 ± 5 DEG C, be added thereto to other raw material, stirring and evenly mixing, then be added thereto to aforesaid glycerol
Solution, mixing, cool down and get final product.
Embodiment 5
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 1 part, hyaluronate sodium (molecular weight 1 × 106) 5 parts, trehalose 5 parts, nicotiamide 5 parts, glycerol 3
Part, allantoin 2 parts, hyetellose 5 parts, D-panthenol 8 parts, lysine 0.5 part, 0.5 part of glutamic acid, glycine 0.5 part, dimension life
Element E0.15 part, deionized water (pH6.5) 25g.
Preparation:
Glycerol is heated to 50 ± 5 DEG C, is added thereto to hyaluronate sodium, allantoin, mixing.
Heat water to 50 ± 5 DEG C, be added thereto to other raw material, stirring and evenly mixing, then be added thereto to aforesaid glycerol
Solution, mixing, cool down and get final product.
Embodiment 6
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 1 part, hyaluronate sodium (molecular weight 1 × 106) 5 parts, trehalose 5 parts, nicotiamide 5 parts, glycerol 3
Part, allantoin 2 parts, hyetellose 5 parts, D-panthenol 8 parts, lysine 2 parts, 3 parts of glutamic acid, glycine 2 parts, vitamin E2
Part, deionized water (pH6.5) 25g.
Preparation:
Glycerol is heated to 50 ± 5 DEG C, is added thereto to hyaluronate sodium, allantoin, mixing.
Heat water to 50 ± 5 DEG C, be added thereto to other raw material, stirring and evenly mixing, then be added thereto to aforesaid glycerol
Solution, mixing, cool down and get final product.
Embodiment 7
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 1 part, hyaluronate sodium (molecular weight 1 × 106) 5 parts, trehalose 5 parts, nicotiamide 5 parts, glycerol 3
Part, allantoin 2 parts, hyetellose 5 parts, D-panthenol 8 parts, lysine 2 parts, 4 parts of glutamic acid, glycine 4 parts, vitamin E2
Part, deionized water (pH6.5) 25g.
Preparation:
Glycerol is heated to 50 ± 5 DEG C, is added thereto to hyaluronate sodium, allantoin, mixing.
Heat water to 50 ± 5 DEG C, be added thereto to other raw material, stirring and evenly mixing, then be added thereto to aforesaid glycerol
Solution, mixing, cool down and get final product.
Embodiment 8
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 1 part, hyaluronate sodium (molecular weight 1 × 106) 5 parts, trehalose 5 parts, nicotiamide 5 parts, glycerol 3
Part, allantoin 2 parts, hyetellose 5 parts, D-panthenol 8 parts, lysine 2 parts, 4 parts of glutamic acid, glycine 4 parts, vitamin E2
Part, azone 0.3 part, sodium laurylsulfate 1.2 parts, deionized water (pH6.5) 25g.
Preparation:
Glycerol is heated to 50 ± 5 DEG C, is added thereto to hyaluronate sodium, allantoin, mixing.
Heat water to 50 ± 5 DEG C, be added thereto to other raw material, stirring and evenly mixing, then be added thereto to aforesaid glycerol
Solution, mixing, cool down and get final product.
Embodiment 9
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 1 part, hyaluronate sodium (molecular weight 1 × 106) 5 parts, trehalose 5 parts, nicotiamide 5 parts, glycerol 3
Part, allantoin 2 parts, hyetellose 5 parts, D-panthenol 8 parts, lysine 2 parts, 4 parts of glutamic acid, glycine 4 parts, vitamin E2
Part, azone 0.3 part, sodium laurylsulfate 0.7 part, deionized water (pH6.5) 25g.
Preparation:
Glycerol is heated to 50 ± 5 DEG C, is added thereto to hyaluronate sodium, allantoin, mixing.
Heat water to 50 ± 5 DEG C, be added thereto to other raw material, stirring and evenly mixing, then be added thereto to aforesaid glycerol
Solution, mixing, cool down and get final product.
Embodiment 10
Prepare ferulic acid and remove skin ulcer water
Formula: ferulic acid 1 part, hyaluronate sodium (molecular weight 1 × 106) 5 parts, trehalose 5 parts, nicotiamide 5 parts, glycerol 3
Part, allantoin 2 parts, hyetellose 5 parts, D-panthenol 8 parts, lysine 2 parts, 4 parts of glutamic acid, glycine 4 parts, vitamin E2
Part, menthol 0.1 part, deionized water (pH6.5) 25g.
Preparation:
Glycerol is heated to 50 ± 5 DEG C, is added thereto to hyaluronate sodium, allantoin, mixing.
Heat water to 50 ± 5 DEG C, be added thereto to other raw material, stirring and evenly mixing, then be added thereto to aforesaid glycerol
Solution, mixing, cool down and get final product.
Functional test
Choosing 100 volunteers, in age 15-35 year, the mean age is 22 years old, each 50 of men and women.All there is acne in face (again
Claim comedo), it is randomly divided into 10 groups, 10 groups are removed skin ulcer water by embodiment 1-10 respectively.
Using method: after face cleaning, take prepared by the appropriate embodiment of the present invention removes skin ulcer water, is massaged into gently and fully absorbs i.e.
Can, every day 2 times, use a course for the treatment of continuously, within 1 week, be a course for the treatment of.
Curative effect:
Skin lesion counting × 100% before curative effect=(skin lesion counting after skin lesion counting-treatment before treatment)/treatment
Curative effect rank:
Effective: skin lesion disappears 60%-90%, and symptom alleviates；
Effective: skin lesion disappears 20%-60%, symptom is improved；
Invalid: skin lesion disappears, and < 20%, clinical symptoms is not improved.
The embodiment 2 of matched group: CN103070804A.
One, statistics takes effect required time (disappear with the skin lesion that takes effect and more than 20% be as the criterion)
Result such as table 1, it is known that the present invention at most needs to take effect for two days.
The duration that takes effect needed for each embodiment of table 1
Two, acne extinction rate after adding up a week
The volunteer application present invention removes skin ulcer water one week, tests acne extinction rate, result such as table 2.
The each embodiment of table 2 go acne effect
It addition, find in Shi Yan, using the prolongation of time with volunteer, it is significant increasing trend that acne improves effect,
Table 3 below only enumerates the trend that disappears of embodiment 1.
Table 3
| 1d acne extinction rate (%) | 3d acne extinction rate (%) | 7d acne extinction rate (%) |
| 27.15 | 52.91 | 86.38 |
Three, statistics cure rate
100 example patients, cure 99 examples altogether, and cure rate reaches 99%.
Last it is noted that various embodiments above is merely to illustrate technical scheme, it is not intended to limit；To the greatest extent
The present invention has been described in detail by pipe with reference to foregoing embodiments, it will be understood by those within the art that: it depends on
So the technical scheme described in foregoing embodiments can be modified, or the most some or all of technical characteristic is entered
Row equivalent；And these amendments or replacement, do not make the essence of appropriate technical solution depart from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a ferulic acid removes skin ulcer water, it is characterised in that be mainly made up of following component:
By weight, ferulic acid 1～2 parts, hyaluronate sodium 0.15～10 parts, trehalose 2～12 parts, nicotiamide 1～10 parts, sweet
Oil 3～12 parts, allantoin 0.4～5 parts, hyetellose 1～9 parts, D-panthenol 0.5～12 parts, water 20-30 part.
Ferulic acid the most according to claim 1 removes skin ulcer water, it is characterised in that by weight, ferulic acid 1～2 parts, hyalomitome
Acid sodium 2～10 parts, trehalose 2～12 parts, nicotiamide 1～10 parts, glycerol 3～8 parts, allantoin 0.4～2 parts, hyetellose 1
～5 parts, D-panthenol 0.5～12 parts, water 20-25 part.
Ferulic acid the most according to claim 1 removes skin ulcer water, it is characterised in that by weight, ferulic acid 1～2 parts, hyalomitome
Acid sodium 5～10 parts, trehalose 5～12 parts, nicotiamide 5～10 parts, glycerol 3～5 parts, allantoin 0.4～2 parts, hyetellose 1
～5 parts, D-panthenol 8～12 parts, water 20-25 part.
Ferulic acid the most according to claim 1 removes skin ulcer water, it is characterised in that by weight, also includes aminoacid and/or dimension
Raw element E；
Described aminoacid is preferably selected from lysine, glutamic acid, glycine one or more, preferably lysine, glutamic acid, sweet
Propylhomoserin mixes with the weight ratio of 1:1-2:1-2.
Ferulic acid the most according to claim 4 removes skin ulcer water, it is characterised in that by weight, also includes lysine 0.5-5
Part, glutamic acid 0.5-5 part, glycine 0.5-5 part, vitamin E 0.15-5 part；
Preferably, lysine 2-5 part, glutamic acid 3-5 part, glycine 2-5 part, vitamin E 0.15-2 part.
6. remove skin ulcer water according to the ferulic acid described in any one of claim 1-5, it is characterised in that water is deionized water, preferably
The water of pH5.5-7.5, more preferably pH6-6.5.
7. remove skin ulcer water according to the ferulic acid described in any one of claim 1-5, it is characterised in that also include penetrating agent, described rush
One or more in oleic acid, menthol, azone, the sodium laurylsulfate of penetration enhancer, preferably azone, sodium laurylsulfate with
The ratio mixing of 1:2-4.
8. remove skin ulcer water according to the ferulic acid described in any one of claim 7, it is characterised in that by weight, penetrating agent 0.1-1.5
Part, preferably 1-1.5 part.
9. the ferulic acid described in any one of claim 1-3 goes the preparation method of skin ulcer water, it is characterised in that comprise the following steps:
All raw materials are mixed at 40-70 DEG C and get final product.
Ferulic acid the most according to claim 9 goes the preparation method of skin ulcer water, it is characterised in that described mixing is further:
Hyaluronate sodium, allantoin mixing are dissolved in glycerol, then hyetellose, D-panthenol, trehalose, nicotiamide are mixed molten
Yu Shuizhong, then by the mixing of above two solution, homogenizing；
Preferably, when all raw materials are mixed at 40-70 DEG C, be additionally added the one in aminoacid, vitamin E and penetrating agent or
Multiple.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610929148.2A CN106309156A (en) | 2016-10-31 | 2016-10-31 | Ferulic acid acne fading solution and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109453055A (en) * | 2018-11-12 | 2019-03-12 | 宁波蒙曼生物科技有限公司 | A kind of acne-expelling face pack liquid and preparation method thereof |
| CN110638692A (en) * | 2019-10-30 | 2020-01-03 | 华南理工大学 | Facial mask liquid with acne inhibiting effect and preparation method thereof |
| CN111195217A (en) * | 2018-11-19 | 2020-05-26 | 上海家化联合股份有限公司 | Single phase oil composition containing ferulic acid |
| CN111643402A (en) * | 2020-06-04 | 2020-09-11 | 昆明滇本生物科技有限公司 | Acne-removing composition containing saw palmetto essential oil and preparation method thereof |
| WO2023097326A1 (en) * | 2021-11-29 | 2023-06-01 | The Procter & Gamble Company | Method for treating post-acne marks |
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| CN103070804A (en) * | 2013-01-28 | 2013-05-01 | 朱进仓 | Acne removing cleanser |
| CN105412141A (en) * | 2015-11-12 | 2016-03-23 | 成都远睿生物技术有限公司 | Medicine for repairing skin injuries and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453055A (en) * | 2018-11-12 | 2019-03-12 | 宁波蒙曼生物科技有限公司 | A kind of acne-expelling face pack liquid and preparation method thereof |
| CN111195217A (en) * | 2018-11-19 | 2020-05-26 | 上海家化联合股份有限公司 | Single phase oil composition containing ferulic acid |
| CN111195217B (en) * | 2018-11-19 | 2023-03-28 | 上海家化联合股份有限公司 | Single phase oil composition containing ferulic acid |
| CN110638692A (en) * | 2019-10-30 | 2020-01-03 | 华南理工大学 | Facial mask liquid with acne inhibiting effect and preparation method thereof |
| CN111643402A (en) * | 2020-06-04 | 2020-09-11 | 昆明滇本生物科技有限公司 | Acne-removing composition containing saw palmetto essential oil and preparation method thereof |
| CN111643402B (en) * | 2020-06-04 | 2021-04-27 | 昆明滇本生物科技有限公司 | Acne-removing composition containing saw palmetto essential oil and preparation method thereof |
| WO2023097326A1 (en) * | 2021-11-29 | 2023-06-01 | The Procter & Gamble Company | Method for treating post-acne marks |
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