CN109620879A

CN109620879A - A kind of wet repairing paste and preparation method thereof clearly

Info

Publication number: CN109620879A
Application number: CN201910136259.1A
Authority: CN
Inventors: 魏元刚; 钟慧; 杨永安; 易铭; 金显友
Original assignee: Nanjing Purple Source Kang Medicine Technology Co Ltd
Current assignee: Nanjing Purple Source Kang Medicine Technology Co Ltd
Priority date: 2019-02-25
Filing date: 2019-02-25
Publication date: 2019-04-16

Abstract

The present invention discloses a kind of wet repairing paste and preparation method thereof clearly, the clear wet repairing paste, by percentage to the quality, composition are as follows: glycyrrhetate and its derivative 0.01~1%, alkannin 0.01~0.1%, Baical Skullcap root P.E 0.05~2%, phellodendron extract 0.05~2%, shrubby sophora extract 0.05~2%, radix paeoniae alba extraction 0.05~2%, Magnolia cortex P.E 0.05~2%, Periostracum Serpentis extract 0.05~2%, fat of Oromaius norvaehollandeae 1~15%, vitamin E 0.05~1%, menthol 0.05~0.5%, auxiliary agent 5.2~44%, surplus are deionized water.The invention also discloses preparation methods.Clear wet repairing paste of the invention has the function of antibacterial convergence, relieving itching and eliminating swelling, prevents from oozing out, releiving inflammation.The problems such as hormone-free and chemically synthesized antiseptic and inhibiting bacteria function ingredient, it is red and swollen to be suitable for itch caused by eczema and all kinds of skin sensitivities, bite by mosquitos.

Description

A kind of wet repairing paste and preparation method thereof clearly

Technical field

The invention belongs to medical and sanitary products technical fields more particularly to a kind of clear wet repairing paste and preparation method thereof.

Background technique

Eczema is a kind of inflammatory reaction dermatoses, can usually be drawn by factors such as extraneous factor stimulation or thereins It rises.Belonging to Chinese medicine " wet sore " " acute eczema " scope, it is in diversity that skin lesion, which is generally symmetric, tendency is obviously oozed out often with having, There can be scratchiness, recurrent exerbation is touching refractory, easily evolves into chronic eczema.Each age group crowd can all fall ill, without obvious gender Difference, with allergic constitution, person is common.

Eczema is known as wet sore by theory of traditional Chinese medical science, and the interpretation of the cause, onset and process of an illness is the dysfunction of the spleen in transport, and dystrophy, ate the object of pungent stimulation more, caused the day after tomorrow Interior raw damp evil accumulates longization heat, pungent supporing yang, leads to retention of damp-heat in the interior, and and every sense wind, wet, the stifling skin of heat evil, cause channels and collaterals by Resistance, qi and blood lose smooth and fall ill.Wet sore is nascent such as scabies, itch without when, sprawling grabs saliva yellow water without stopping, contamination in flakes, mostly because of internal heat spleen Caused by wet wind-engaging.Therefore, the key for treating wet sore is heat-clearing wind-dispelling, dehumidifying promoting blood circulation, focuses on treating both manifestation and root cause of disease, should pay attention to damp and hot Mark as it is basic to take the dysfunction of the spleen in transport into account again.

The external treatment with Chinese medicine method of eczema is varied, mainly includes Chinese medicine external, acupuncture and moxibustion treatment, catgut implantation at acupoint, bloodletting treatment Method, point-application, scraping treatment, massage treatment.External treatment of traditional Chinese medicine treatment eczema has given full play to the excellent of China's Chinese Traditional Medicine Gesture provides treatment method more effective and abundant, and side effect is low, and idicatio is wide, and recurrence rate is low.But still there are many deficiencies Place, such as excessively cumbersome and strongly professional or some treatments of certain operations have the problems such as unavoidable pain.

And the treatment of existing Chinese medicine, formula have single type or limitation or medicinal material composition compatibility it is unreasonable or because Or extraction imperfect to the extraction of its effective component is unreasonable, not in place during processing or processing, to a certain extent The effect of depth therapy is not achieved, thus treatment is caused to be not thorough easy recurrence.

And addition steroids or antibiotics different degrees of in existing Western medicine, there are certain toxic side effect or It is easy to produce antibody, treatment is not achieved there are also some drugs and repairs the purpose of diseased region.It is just common for skin disease at present The curative effects limitation such as aqua, tincture it is undesirable, cure rate is low, recurrent exerbation, especially for some exudations for having resulted in infection Property, rotten to the corn dermatoses curative effect it is less obvious, stress and burden can not only be caused to patient, while returning patient and increasing warp Ji burden.

Application No. is the patents of CN201710422942.2 to disclose a kind of infantile eczema cream and preparation method thereof.The baby Youngster's eczema ointment is made of the raw material of following mass percent: shea butter 1-3%, coconut oil 0-4.6%, lanolin 1.9-5%, Baical Skullcap root P.E 0.5-2%, phellodendron extract 0.4-2%, common cnidium fruit P.E 0.05-0.2%, Fructus Kochiae extract 0.1- 0.5%, allantoin 0.1-0.5%, bisabolol 0.05-0.2%, menthyl lactate 0.1-2%, surfactant 2-5%, sweet Oxalic acid dipotassium 0.1-0.5%, stearic acid 1-10%, octadecyl alcolol 1-5.5%, glycerol 0.3-7%, methyl hydroxybenzoate 0-10%, oxybenzene Propyl ester 0-0.5%, essence 0-1%, thickener 0.1-25%, water surplus.The invention infantile eczema cream is matched using a variety of Chinese herbal medicines 5, its mutual synergistic effect is played, there is clearing heat and detoxicating, heat-clearing and damp-drying drug, antibacterial anti-inflammatory, dispelling wind and arresting itching multiple efficacies, pharmacological property temperature With it is quick, non-stimulated to skin and without side-effects.

Application No. is the patents of CN201710117602.9 to provide a kind of pharmaceutical composition, wet for preventing and treating infant eczema Rash cream and preparation method thereof.The active constituent of the pharmaceutical composition of the prevention and treatment infant eczema is prepared by the component of following mass parts It forms: 1-10 parts of Honegsukle flower P.E, 0.5-5 parts of oat alkaloid, 0.5-5 parts of chlorhexidine gluconate.The prevention and treatment of the invention The pharmaceutical composition of infant eczema has the function of clearing heat and detoxicating, scattered carbuncle detumescence, bacterio static itching-relieving, can effectively prevent infant Eczema, diaper rash Niao Xian, milk Zhen Nai Xian, bite by mosquitos, dermatorrhea eczema, skin allergy, itch, dermatitis, damp and hot prickly heat etc., and to baby The control efficiency of infantile eczema is significant, and is free of antibiotic, hormone, has no toxic side effect, mildly non-stimulated to skin, and will not produce Raw drug dependence, will not recur after recovery from illness.

In above-mentioned patent, although first patent using a variety of Chinese herbal medicine compatibilities, and has certain effect, in antibacterial side Face only tests out certain activity, and does not detect bacteriostasis rate in detail to compare fungistatic effect, and be added to methyl hydroxybenzoate With both chemical synthesis preservatives of Nipasol, dosage is not also low, and there are certain sensitization and irritations.

Second patent reaches fungistatic effect by chemical synthesis bacteriostatic agent equally at antibacterial aspect, and 2 months 2017 2 Day U.S. Food and Drug Administration (FDA) issues drug safety information: the product containing chlorhexidine gluconate exists rare See but serious allergic reaction.1998, FDA just alerted the dressing that medical personnel contains chlorhexidine gluconate and vein is defeated The Medical Devices such as liquid pipe line have the risk of severe allergic reaction.Although such adverse reaction is very rare, in the past few years Increased trend year by year is presented.

Contain some ingredients being used with caution in current some eczema ointments, the safety used does not ensure, may bring tight The side effect of weight, and have ignored the maintenance effect for skin.Therefore, search out it is a kind of not only can safe treatment eczema, but also can The eczema ointment of skin care is urgent problem.

Summary of the invention

Goal of the invention: in order to make up for the deficiencies of the prior art, the present invention provides a kind of clear wet repairing paste and its preparation sides Method.Skin infection caused by clear wet repairing paste produced by the present invention can effectively prevent because of staphylococcus aureus and Escherichia coli, With good inhibiting bacteria and diminishing inflammation effect.

Technical solution: clear wet repairing paste of the present invention, by percentage to the quality, composition are as follows: glycyrrhetate and its spread out Biological 0.01~1%, alkannin 0.01~0.1%, Baical Skullcap root P.E 0.05~2%, phellodendron extract 0.05~2%, kuh-seng Extract 0.05~2%, radix paeoniae alba extraction 0.05~2%, Magnolia cortex P.E 0.05~2%, Periostracum Serpentis extract 0.05~2%, Fat of Oromaius norvaehollandeae 1~15%, vitamin E 0.05~1%, menthol 0.05~0.5%, auxiliary agent 5.2~44%, surplus are deionization Water.

Glycyrrhizic acid is one of most important effective component in Radix Glycyrrhizae, has the effects that anti-inflammatory, antiviral and enhancing is immune, mesh Preceding glycyrrhizic acid is all applied in a salt form, such as mono-ammonium, diamine salts, monopotassium salt, di-potassium, disodium salt, trisodium salt, Because existing in a salt form relatively stable；In glycyrrhetate used in the present invention and its derivative, contain single glucuronic acid Enoxolone is to be obtained by glycyrrhetate by certain glucosides enzyme hydrolysis, as the derivative of glycyrrhizic acid, in anti-inflammatory and anti-mistake Equally or more than glycyrrhizic acid in quick activity, and polarity can smoothly enter into cell between glycyrrhizic acid and enoxolone, in body Interior solubility and transmembrane transport ability is all stronger than them, thus has better bioavilability, and has significant anticancer Effect.Preferably, in clear wet repairing paste, the mass percent of glycyrrhetate and its derivative is 0.1~1%, preferably 0.1~ 0.5%.Wherein, the glycyrrhetate and its derivative are single by the glycyrrhetate of mass percent 70~80% and 20~30% Glucuronic acid enoxolone composition, wherein glycyrrhizic acid is selected from one of ammonium glycyrrhizunate, sodium glycyrrhetate, potassium glycyrrhizana Or it is several, ammonium glycyrrhizunate is selected from ammonium glycyrrhizinate, diammonium glycyrrhizinate, and sodium glycyrrhetate is selected from disodium glycyrrhizinate, glycyrrhizic acid three Sodium, potassium glycyrrhizana are selected from glycyrrhizic acid list potassium, dipotassium glycyrrhizinate.Further, by percentage to the quality, the glycyrrhetate And its derivative composition is as follows: ammonium glycyrrhizunate 65~70%, sodium glycyrrhetate 3~5%, potassium glycyrrhizana 3~5%, single Portugal Grape uronic acid enoxolone 20~25%；Further, the glycyrrhetate and its derivative composition are as follows: ammonium glycyrrhizunate 70%, sodium glycyrrhetate 5%, potassium glycyrrhizana 5%, Glycyrrhetic acid 3-O-mono-BETA-D-glucuronide 20%.

Asian puccoon is peculiar naturally to resist inflammation, epidermis repairing activity ingredient alkannin, and has certain antioxidant activity, uses peace Entirely, effect is good.Suitable for various skin quality, there is the effect of anti-inflammatory, hemostasis, promotion skin regeneration, cell metabolism, it can be rapidly It penetrates into skin, promote wound healing.Preferably, in clear wet repairing paste, the mass percent of alkannin is 0.01~0.08%, excellent It is selected as 0.01~0.02%.

Radix scutellariae has the effect of heat-clearing and damp-drying drug, purging fire for removing toxin, and main component scutelloside, baicalein can effectively inhibit large intestine bar A variety of harmful bacterias such as bacterium, staphylococcus.

Effect that Cortex Phellodendri has heat-clearing and damp-drying drug, expelling wind and activating blood flow, desinsection antipruritic, the modern pharmacology proves that, containing jamaicin, A variety of alkaloids such as magnoflorine, jateorrhizine and palmatine, anti-inflammatory, analgesia, antimicrobial, oxidation resistant effect are significant. Preferably, in clear wet repairing paste, the mass percent of phellodendron extract is 0.1~1%, preferably 0.1~0.2%.

Kuh-seng has effects that heat-clearing and damp-drying drug, desinsection, diuresis, and clinic is usually used in eczema, pruitus, trichomonas vaginitis Deng.Its root system contains a variety of alkaloids, flavonoids, significantly inhibits to Escherichia coli, staphylococcus aureus etc..

Radix Paeoniae Alba, main component total glucoside have significant analgesia, calm, anticonvulsant action and anti-inflammatory and immune Adjustment effect, Immunity regulation that can be excessively high or too low by patient improve some allergy to normal condition so as to alleviate Property skin problem (such as: eczema, nettle rash).Preferably, in clear wet repairing paste, the mass percent of radix paeoniae alba extraction is 0.1 ~1%, preferably 0.1~0.2%.

It is Cortex Magnoliae Officinalis acrid flavour, warm-natured, have effects that promoting the circulation of qi dampness elimination, warm in pain, relieving asthma.Phenols component tool in Cortex Magnoliae Officinalis There is apparent bactericidal effect, Cortex Magnoliae Officinalis decoction has staphylococcus, streptococcus, dysentery with bloody stool bacillus, Pasteurella, comma bacillus stronger Antibacterial action.

Snake slough has effects that expelling wind and removing nebula, improving eyesight, removing toxic substances, desinsection, analgesic, it can also be used to treat child convulsion, skin The diseases such as itch, sore throat, mesh screen, acute mastitis and chorionic epithelioma, it is preferred that in clear wet repairing paste, snake slough is mentioned The mass percent for taking object is 0.1~1%, preferably 0.1~0.2%.

Fat of Oromaius norvaehollandeae is that a kind of grease extracted in birds emu is originated in from Australia, has percdation ability, can promote healing Burn, eczema, dermatitis and other skin diseases.Fat of Oromaius norvaehollandeae can also have analgesic effect to myalgia, make to due to sports At injury, arthritis have quick anti-inflammatory analgesic action.Preferably, in clear wet repairing paste, the mass percent of fat of Oromaius norvaehollandeae is 5 ~12%, preferably 5~10%.

Vitamin E can effectively antagonize free radical, inhibit lipid peroxide to generate, eliminate chloasma；Inhibit tyrosinase Activity, to reduce melanin production.Also having simultaneously promotes effective component to absorb, the effect of aid in skin reparation.Preferably, In clear wet repairing paste, the mass percent of vitamin E is 0.1~0.6%, preferably 0.1~0.2%.

The cold exhausted receptor of the stimulation human skin and mucous membrane of the menthol property of can choose, generates cold exhausted reflection and creeping chill, Cause the contraction of skin and mucosa blood vessel and deep tissue blood vessel, local blood circulation can be promoted, mitigates edema and pain, in skin Skin local topical menthol, there is apparent refrigerant sense, can play the effect of certain anti-inflammatory anti-itch analgesic.Preferably, clear wet In repairing paste, the mass percent of menthol is 0.1~0.5%, preferably 0.1~0.2%.

Baical Skullcap root P.E, phellodendron extract, shrubby sophora extract, radix paeoniae alba extraction, Magnolia cortex P.E and the snake slough mentions Taking object is alcohol extracting thing, such as ethanol extract, can sufficiently be extracted each effective component.

Specifically, the general preparative methods of each extract are as follows: taking corresponding medicinal material, 6~15 times of ethyl alcohol of its weight ratio are added Aqueous solution (mass fraction be 60~95%), 70~90 DEG C at a temperature of refluxing extraction 1~3 hour, then filter, medicinal material is anti- It extracts 2~4 times again, merging filtrate, concentrate drying obtains corresponding extract；

Preferably, in the general preparative methods of each extract, the mass fraction of ethanol water is 80%, is used The weight ratio that amount is 10 times, Extracting temperature are 85 DEG C, and extraction time is 2 hours, and extraction time is 2 times.

Baical Skullcap root P.E produced by the present invention, shrubby sophora extract magnolia obovata extract in bacteriostasis there is collaboration to make With can enhance fungistatic effect, improve antibacterial protective effect.Preferably, in clear wet repairing paste, the mass percent of Baical Skullcap root P.E It is 0.1~1%, the mass percent of shrubby sophora extract is 0.1~1%, and the mass percent of Magnolia cortex P.E is 0.1~1%. Preferably, the mass percent of Baical Skullcap root P.E is 0.2~1%, and the mass percent of shrubby sophora extract is 0.2~1%, Cortex Magnoliae Officinalis The mass percent of extract is 0.5~1%.

The auxiliary agent is in solubilizer, thickener, moisturizer, emulsifier, penetrating agent, cosolvent, acid-base modifier One or more, be acceptable additive and auxiliary material in medical and sanitary products.

The solubilizer is selected from one or more of poloxamer, Crodaret, is preferably pool Luo Shamu 188, mass percent shared by the solubilizer are 1~10%, preferably 1~6%, more preferably 1~4%.

The thickener is selected from one of carbomer series, cellulose derivative, xanthan gum, sodium alginate or several It plants, preferably carbomer U20, mass percent shared by the thickener is 0.2~1%, preferably 0.4~1%, more preferably 0.4~0.8%.

The moisturizer is selected from one or more of glycerol, propylene glycol, 1,3-BDO, polyethylene glycol, sorbierite, Preferably glycerol or/and propylene glycol, mass percent shared by the moisturizer are 1~10%, preferably 5~10%.

The emulsifier is in polyethenoxy ether class, fatty alcohol polyethenoxy ether class, polyol fatty acid ester class One or more, preferably 305 emulsifiers or/and glycerin monostearate, mass percent shared by the emulsifier is 0.6~ 5%, preferably 1~5%, more preferably 1~1.5%.

The penetrating agent be selected from sulfoxide type, pyrrolones, azone class, fitter acids and its ester class, terpenes, phosphide class, One or more of amine and amides, preferably azone, mass percent shared by the penetrating agent are 0.2~2%, preferably 0.5~1.5%, more preferably 0.5~1%.

The cosolvent is selected from one or more of ethyl alcohol, propylene glycol, 1,3-BDO, polyethylene glycol, preferably Propylene glycol or/and 1,3-BDO, the cosolvent account for 2~15%, preferably 2~10%, while can As moisturizer.

The acid-base modifier is in citric acid, sodium citrate, tartaric acid, acetic acid, sodium hydroxide, triethanolamine One or more, preferably triethanolamine, which accounts for 0.2~1%, preferably 0.4~ 1%, more preferably 0.4~0.8%.

Preferably, clear wet repairing paste of the present invention, by percentage to the quality, composition are as follows: glycyrrhetate and its derivative Object 0.1-1%, alkannin 0.01-0.08%, Baical Skullcap root P.E 0.1~1%, phellodendron extract 0.1~1%, shrubby sophora extract 0.1~1%, radix paeoniae alba extraction 0.1~1%, Magnolia cortex P.E 0.1~1%, Periostracum Serpentis extract 0.1~1%, fat of Oromaius norvaehollandeae 5~ 12%, vitamin E 0.1~0.6%, menthol 0.1~0.5%, auxiliary agent 10.3~34.5%, surplus are deionized water.

The pH of the clear wet repairing paste is 5.5~7.5.

The preparation method of clear wet repairing paste of the present invention includes:

By formula ratio, solubilizer, thickener are taken, portions of de-ionized water is added, after dissolution in 10~40 minutes is stirred at room temperature, 70~90 DEG C are heated to, stirring is swollen thickener sufficiently in 20~40 minutes, adds moisturizer, glycyrrhetate and its derivative Object, emulsifier, fat of Oromaius norvaehollandeae, penetrating agent, vitamin E, heat preservation are sufficiently stirred 20~40 minutes；It is cooled to 40~60 DEG C later, adds Enter the Baical Skullcap root P.E dissolved with cosolvent, phellodendron extract, shrubby sophora extract, radix paeoniae alba extraction, Magnolia cortex P.E, snake slough to mention Object, alkannin and menthol are taken, 10~30 minutes is stirred to being sufficiently mixed, is eventually adding acid-base modifier, and supplement surplus Deionized water is in pH between 5.5~7.5, is sufficiently stirred 10~30 minutes, and cooling to obtain the final product.

Preferably, the preparation method of clear wet repairing paste of the present invention includes:

By formula ratio, solubilizer, thickener are taken, portions of de-ionized water is added, after dissolution in 10~40 minutes is stirred at room temperature, 80~85 DEG C are heated to, stirring is swollen thickener sufficiently in 30~40 minutes, adds moisturizer, glycyrrhetate and its derivative Object, emulsifier, fat of Oromaius norvaehollandeae, penetrating agent, vitamin E, heat preservation are sufficiently stirred 20~30 minutes；It is cooled to 45~50 DEG C later, adds Enter the Baical Skullcap root P.E dissolved with cosolvent, phellodendron extract, shrubby sophora extract, radix paeoniae alba extraction, Magnolia cortex P.E, snake slough to mention Object, alkannin and menthol are taken, 20~30 minutes is stirred to being sufficiently mixed, is eventually adding acid-base modifier, and supplement surplus Deionized water is in pH between 6~7, is sufficiently stirred 20~30 minutes, and cooling to obtain the final product.

The utility model has the advantages that

Clear wet repairing paste of the invention, predominantly active skull cap components are free of chemical synthesis preservative, safe and reliable stingless Swash.By combining the effect of Baical Skullcap root P.E, shrubby sophora extract magnolia obovata extract Combination, while upper glycyrrhetate of arranging in pairs or groups And its natural components such as derivative, alkannin, phellodendron extract, radix paeoniae alba extraction, Periostracum Serpentis extract, fat of Oromaius norvaehollandeae, it plays antibacterial It restrains, the effect of relieving itching and eliminating swelling.Wherein, Baical Skullcap root P.E, shrubby sophora extract magnolia obovata extract play association in bacteriostasis Same-action has stronger bacteriostasis, while the chemical synthesis in substitution compared to the same dose of single ingredients Preservative, be originated from natural plants, have higher safety.Glycyrrhetate and its derivative, alkannin, Cortex Phellodendri, Radix Paeoniae Alba, snake It sloughs off and plays synergistic effect on anti-inflammatory repair function, compared to the same dose of single ingredients, there are stronger function and effect.It is yellow Cypress, Radix Paeoniae Alba, snake slough, menthol influence each other antipruritic effect.

The additive capacity of each ingredient of reasonable balance of the present invention, makes product play one's part to the full, external preparation for skin, has antibacterial receipts It holds back, relieving itching and eliminating swelling, prevent from oozing out, the effect for inflammation of releiving.Hormone-free and chemically synthesized antiseptic and inhibiting bacteria function ingredient, it is natural stingless Swash, the problems such as it is red and swollen to be suitable for itch caused by eczema and all kinds of skin sensitivities, bite by mosquitos, refrigerant antipruritic, care skin.This Invention product preparation process simple process, the period is short, is readily produced, and the market competitiveness is strong, has a extensive future.

Specific embodiment

Combined with specific embodiments below, the present invention is furture elucidated.

In the specific embodiment of the invention,

Glycyrrhetate and its derivative and alkannin derive from hundred million Li Nai sparrow Biotechnology Co., Ltd, wherein glycyrrhizic acid Salt and its derivative are mixture, specific ingredient by percentage to the quality, by ammonium glycyrrhizunate (specially ammonium glycyrrhizinate) 70%, sodium glycyrrhetate (specially disodium glycyrrhizinate) 5%, potassium glycyrrhizana (specially dipotassium glycyrrhizinate) 5%, single glucose Aldehydic acid enoxolone (CAS:34096-83-8) 20% forms.

Baical Skullcap root P.E, phellodendron extract, shrubby sophora extract, radix paeoniae alba extraction, Magnolia cortex P.E and Periostracum Serpentis extract General preparative methods it is as follows:

Corresponding medicinal material is taken, the ethanol water (mass fraction 80%) of 10 times of its weight ratio is added, flows back at 85 DEG C It extracts 2 hours, then filters, medicinal material extracts 2 times repeatedly, merging filtrate, and concentrate drying obtains corresponding extract.

A kind of clear wet repairing paste of embodiment 1

Formula components (200g), by percentage to the quality, composition are as follows: glycyrrhetate and its derivative 0.5%, alkannin 0.02%, Baical Skullcap root P.E 0.2%, phellodendron extract 0.2%, shrubby sophora extract 0.2%, radix paeoniae alba extraction 0.2%, Cortex Magnoliae Officinalis mention Take object 0.5%, Periostracum Serpentis extract 0.2%, fat of Oromaius norvaehollandeae 10%, vitamin E 0.2%, menthol 0.2%, poloxamer 1884%, carbomer U200.8%, glycerol 5%, 305 emulsifiers 0.5%, glycerin monostearate 1%, azone 1%, propylene glycol 10%, triethanolamine 0.8%, deionized water add to 200g.

Preparation method:

By formula ratio, PLURONICS F87, carbomer U20 are taken, portions of de-ionized water is added, is stirred at room temperature 10~40 points After clock dissolution, be heated to 80~85 DEG C, stirring is swollen thickener sufficiently in 30~40 minutes, add glycerol, glycyrrhetate and Its derivative, 305 emulsifiers, glycerin monostearate, fat of Oromaius norvaehollandeae, azone, vitamin E, heat preservation are sufficiently stirred 20~30 minutes； It is cooled to 45~50 DEG C later, Baical Skullcap root P.E that addition is dissolved with propylene glycol, phellodendron extract, shrubby sophora extract, Radix Paeoniae Alba mention Object, Magnolia cortex P.E, Periostracum Serpentis extract, alkannin and menthol are taken, 20~30 minutes is stirred to being sufficiently mixed, is eventually adding Triethanolamine, and balance deionized water is supplemented, pH is about 6.3, is sufficiently stirred 20~30 minutes, and cooling to obtain the final product.

A kind of clear wet repairing paste of embodiment 2

Formula components (200g), by percentage to the quality, composition are as follows: glycyrrhetate and its derivative 0.1%, alkannin 0.01%, Baical Skullcap root P.E 1%, phellodendron extract 0.1%, shrubby sophora extract 1%, radix paeoniae alba extraction 0.1%, Magnolia cortex P.E 1%, Periostracum Serpentis extract 0.1%, fat of Oromaius norvaehollandeae 5%, vitamin E 0.1%, menthol 0.1%, PLURONICS F87 1%, carbomer U200.4%, glycerol 5%, 305 emulsifiers 0.4%, glycerin monostearate 0.6%, azone 0.5%, propylene glycol 2%, three second Hydramine 0.4%, deionized water adds to 200g.

The preparation method is the same as that of Example 1.

A kind of clear wet repairing paste of embodiment 3

Formula components (200g), by percentage to the quality, composition are as follows: glycyrrhetate and its derivative 1%, alkannin 0.08%, Baical Skullcap root P.E 0.1%, phellodendron extract 1%, shrubby sophora extract 0.1%, radix paeoniae alba extraction 1%, Magnolia cortex P.E 0.1%, Periostracum Serpentis extract 1%, fat of Oromaius norvaehollandeae 12%, vitamin E 0.6%, menthol 0.5%, PLURONICS F87 6%, card wave Nurse U201%, glycerol 10%, 305 emulsifiers 2%, glycerin monostearate 3%, azone 1.5%, propylene glycol 10%, three ethyl alcohol Amine 1%, deionized water adds to 200g.

The preparation method is the same as that of Example 1.

The clear wet repairing paste fungistatic effect test of 4 present invention of embodiment

Detection method: choosing Escherichia coli, staphylococcus aureus both bacterium, with reference to GB15979-2002 appendix C 4 into Row bacteriostatic test (the processing time is 2 minutes).Concrete outcome is as follows:

The clear wet repairing paste fungistatic effect test of 1 present invention of table

Group	To Escherichia coli bacteriostasis rate	To staphylococcus aureus bacteriostasis rate
			Embodiment 1	98.6%	98.5%
Embodiment 2	99.5%	99.2%
			Embodiment 3	74.3%	73.5%

As seen from the above table, the clear wet repairing paste which provides has apparent bacteriostasis, can effectively prevent because golden yellow Skin infection caused by color staphylococcus and Escherichia coli.

The synergistic effect of three kinds of antipathogenic compositions in the clear wet repairing paste of 5 present invention of embodiment

It is control with embodiment 1, and based on its formula, three kinds of antipathogenic compositions are variable, compare fungistatic effect, below For the formula rate of several groups of variable parts (i.e. active constituent):

(1) Baical Skullcap root P.E 0.45%, shrubby sophora extract 0.45%, do not add Magnolia cortex P.E；

(2) Baical Skullcap root P.E 0.3%, Magnolia cortex P.E 0.6%, do not add shrubby sophora extract；

(3) shrubby sophora extract 0.3%, Magnolia cortex P.E 0.6%, do not add Baical Skullcap root P.E；

Wherein, compared to embodiment 1, the amount of the ingredient added less is shared out equally in remaining two kinds of ingredients, to keep antibacterial The total amount of active constituent is identical, i.e., and 0.9%；If the fungistatic effect of three kinds of ingredients is addition, then the suppression of this three group of formula It is higher than the data of control sample in an at least meeting in bacterium result；If the bacteriostasis rate of three group of formula is lower than control sample, illustrate What is sent out between three kinds of ingredients is synergistic effect；

The result is as follows:

The synergistic effect of three kinds of antipathogenic compositions in the clear wet repairing paste of 2 present invention of table

Group	To Escherichia coli bacteriostasis rate	To staphylococcus aureus bacteriostasis rate
			Control sample	98.6%	98.5%
Formula 1	82.1%	81.5%
			Formula 2	86.5%	81.8%
Formula 3	82.7%	88.3%

As seen from the above table, the bacteriostasis rate of three group of formula is lower than control sample, and three kinds of antipathogenic compositions are in antibacterial work in the present invention It is cooperateed with there is complementation.

Inhibiting effect of the clear wet repairing paste of 6 present invention of embodiment to the swelling of croton oil induced mice ear

Material: Kun Ming mice, 20~25g of weight, half male and half female；PINGYANPING RUANGAO (three nine-day periods after the winter solstice enterprise group)；Crotons Oil；Physiological saline；The made paste of embodiment 1.

Method: small white mouse 80 is only randomly divided into 8 groups, and PINGYANPING RUANGAO group, physiological saline group and 6 experimental groups are given respectively Give corresponding medicament, dosage be 0.lg/ only, be coated in mouse right ear two sides, successive administration 3 days, after last dose 1h, then at mouse Auris dextra two sides applies 2% croton oil, 50 μ L/ and only causes to swell, and left ear is not painted with normal ear.Cervical dislocation puts to death mouse after 6h, is punched with 6mL Device sweeps away the disk at the same position of left and right ear, and in weighing on torsion power balance, it is swelling that auris dextra weight, which subtracts left ear weight, than Compared with the anti-inflammatory effect of each group.

Paste used in experimental group: (based on embodiment 1, anti-inflammatory component (glycyrrhetate and its derivative, Asian puccoon are kept Element, phellodendron extract, radix paeoniae alba extraction, Periostracum Serpentis extract) total amount is constant, i.e., 1.12%)

Experimental group 1: glycyrrhetate and its derivative 0.5%, alkannin 0.02%, phellodendron extract 0.2%, Radix Paeoniae Alba are extracted Object 0.2%, Periostracum Serpentis extract 0.2%；

Experimental group 2: glycyrrhetate and its derivative 1.12%；

Experimental group 3: alkannin 1.12%；

Experimental group 4: phellodendron extract 1.12%；

Experimental group 5: radix paeoniae alba extraction 1.12%；

Experimental group 6: Periostracum Serpentis extract 1.12%；

The paste of the present invention of table 3 causes the influence (X ± S, n=10) of small white mouse auricle edema to croton oil

Group	Auricle swelling degree (mg)
		PINGYANPING RUANGAO group	3.56±1.85**
Physiological saline group	9.23±2.76
		Experimental group 1	4.25±2.51*
Experimental group 2	6.52±2.23*
		Experimental group 3	6.36±2.16*
Experimental group 4	8.15±2.82
		Experimental group 5	7.27±2.40*
Experimental group 6	8.21±2.71

Note: with physiological saline group ratio: P < 0.001 * P < .01, * *

As shown in Table 3, the made paste of embodiment 1 can be readily apparent that the auricle edema for inhibiting croton oil to cause small white mouse, Swelling is significantly lower than physiological saline group.And 5 kinds of anti-inflammatory components have synergistic effect in the present invention.

The synergistic effect of 4 kinds of antipruritic ingredients in the clear wet repairing paste of 7 present invention of embodiment

Material: Kun Ming mice, 20~25g of weight, half male and half female；Dextran.

Take mouse 60, half male and half female, the hair for sloughing skin after mouse incidence ear for 1 day in advance is spare, and each experimental group connects Continuous administration 3 days, dosage be 0.1g/ only, after last medication 1 hour lose hair or feathers position subcutaneous injection dextran 0.2mL/ times to get Mouse itch model.

Itch model mice is randomly divided into 1 model group and 5 experimental groups, every group 10, each group respectively will be corresponding tested Paste be uniformly applied to depilation position, model group smear physiological saline, continuous use 3 days.It is scratched with scratch one's head portion, rear solid end of mouse fore paw Trunk, mouth sting each position of whole body as itch indication, mouse itch number in 15min after tickling for record the 1st time.

Paste used in experimental group: (based on embodiment 1, antipruritic ingredient (phellodendron extract, radix paeoniae alba extraction, snake are kept Slough off extract, menthol) total amount is constant, i.e., 0.8%)

Experimental group 1: phellodendron extract 0.2%, radix paeoniae alba extraction 0.2%, Periostracum Serpentis extract 0.2%, menthol 0.2%；

Experimental group 2: phellodendron extract 0.8%；

Experimental group 3: radix paeoniae alba extraction 0.8%；

Experimental group 4: Periostracum Serpentis extract 0.8%；

Experimental group 5: menthol 0.8%；

The synergistic effect (X ± S, n=10) of 4 kinds of antipruritic ingredients in 4 present invention of table

Group	Itch number/time/15min
		Physiological saline group	10.32±1.54
Experimental group 1	5.61±1.53**
		Experimental group 2	8.71±1.62*
Experimental group 3	7.63±1.72*
		Experimental group 4	8.65±1.95*
Experimental group 5	8.21±2.04*

Note: with physiological saline group ratio: P < 0.001 * P < .01, * *

4 kinds of antipruritic ingredients have synergistic effect in the present invention as seen from the above table.

The clear wet repairing paste clinical trial result of 8 present invention of embodiment

Be selected in 204 patients of patient altogether and carry out clinical observations, male 103, female 101, the age between 5-60 years old, wherein The column of eczema 143, insect dermatitis 61；

It is required that the made paste sample of embodiment 1 is applied to affected part after subject cleans affected part with clear water, and 3 times a day, 1 week It is as a treatment course.

Effect criterion:

Recovery from illness: skin lesion is all subsided, and pruritis disappears, and curative effect rate is up to 100%；

It is effective: skin lesion obviously subside or it is most of subside, itch is substantially reduced, and curative effect rate is up to 70% or more；

Effective: skin lesion partial remission, pruritis make moderate progress, and curative effect rate is up to 30% or more；

Invalid: skin lesion recession is unobvious, and itch has no that mitigation or clinical symptoms deteriorate, and curative effect rate is not up to 30%.

Curative effect rate: curative effect rate=(total mark after total mark-treatment before treating)/total mark × 100% before treating

As a result: as shown in Table 5, in 204 triers, only 4 in vain, total effective rate 98.04%, wherein eczema trier Effective percentage is 97.90%, and insect dermatitis trier's effective percentage is 98.36%.

Each subject's effect of table 5

To sum up, the present invention has the function of good inhibiting bacteria and diminishing inflammation, and eczema can be effectively relieved and all kinds of skin sensitivities cause Itch it is red and swollen, the problems such as bite by mosquitos.

Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention And range.

Claims

1. a kind of clear wet repairing paste, which is characterized in that by percentage to the quality, composition are as follows:

Glycyrrhetate and its derivative 0.01~1%, alkannin 0.01~0.1%, Baical Skullcap root P.E 0.05~2%, Cortex Phellodendri mention Take object 0.05~2%, shrubby sophora extract 0.05~2%, radix paeoniae alba extraction 0.05~2%, Magnolia cortex P.E 0.05~2%, snake Slough off extract 0.05~2%, fat of Oromaius norvaehollandeae 1~15%, vitamin E 0.05~1%, menthol 0.05~0.5%, auxiliary agent 5.2~ 44%, surplus is deionized water.

2. clear wet repairing paste according to claim 1, which is characterized in that the Baical Skullcap root P.E, phellodendron extract, hardship Conopsea extraction, radix paeoniae alba extraction, Magnolia cortex P.E and Periostracum Serpentis extract are alcohol extracting thing.

3. clear wet repairing paste according to claim 2, which is characterized in that the Baical Skullcap root P.E, phellodendron extract, hardship Conopsea extraction, radix paeoniae alba extraction, Magnolia cortex P.E and Periostracum Serpentis extract extracting method include: to take corresponding medicinal material, it is added 6~15 times of ethanol waters of weight ratio, 70~90 DEG C at a temperature of refluxing extraction 1~3 hour, then filter, medicinal material is repeatedly It extracts 2~4 times, merging filtrate, concentrate drying obtains corresponding extract；The mass fraction of the ethanol water be 60~ 95%.

4. clear wet repairing paste according to claim 1, which is characterized in that the auxiliary agent is selected from solubilizer, thickener, guarantor One or more of humectant, emulsifier, penetrating agent, cosolvent, acid-base modifier.

5. clear wet repairing paste according to claim 4, which is characterized in that the solubilizer is selected from poloxamer, polyoxy One or more of ethylene hydrogenation castor oil, mass percent shared by the solubilizer are 1~10%；The thickener choosing From one or more of carbomer series, cellulose derivative, xanthan gum, mass percent shared by the thickener is 0.2 ~1%.

6. clear wet repairing paste according to claim 4, which is characterized in that the moisturizer is selected from glycerol, propylene glycol, 1, One or more of 3- butanediol, polyethylene glycol, sorbierite, mass percent shared by the moisturizer are 1~10%；It is described Emulsifier be selected from one or more of polyethenoxy ether class, fatty alcohol polyethenoxy ether class, polyol fatty acid ester class, should Mass percent shared by emulsifier is 0.6~5%.

7. clear wet repairing paste according to claim 4, which is characterized in that the penetrating agent is selected from sulfoxide type, pyrrolones One or more of class, azone class, fitter acids and its ester class, terpenes, phosphide class, amine and amides, shared by the penetrating agent Mass percent be 0.2~2%；The cosolvent in ethyl alcohol, propylene glycol, 1,3-BDO, polyethylene glycol one Kind is several, which accounts for 2~15%；The acid-base modifier be selected from citric acid, tartaric acid, One or more of acetic acid, sodium hydroxide, triethanolamine, the acid-base modifier account for 0.2~1%.

8. clear wet repairing paste according to claim 1, which is characterized in that the clear wet repairing paste pH is 5.5~7.5.

9. clear wet repairing paste according to claim 1, which is characterized in that by percentage to the quality, composition are as follows: glycyrrhetate And its derivative 0.1~1%, alkannin 0.01~0.08%, Baical Skullcap root P.E 0.1~1%, phellodendron extract 0.1~1%, Shrubby sophora extract 0.1~1%, radix paeoniae alba extraction 0.1~1%, Magnolia cortex P.E 0.1~1%, Periostracum Serpentis extract 0.1~1%, Fat of Oromaius norvaehollandeae 5~12%, vitamin E 0.1~0.6%, menthol 0.1~0.5%, auxiliary agent 10.3~34.5%, surplus be go from Sub- water.

10. a kind of preparation method of clear wet repairing paste characterized by comprising press formula ratio, take solubilizer, thickener, be added Portions of de-ionized water after dissolution in 10~40 minutes is stirred at room temperature, is heated to 70~90 DEG C, stirring makes thickener in 20~40 minutes Sufficiently swelling, adds moisturizer, glycyrrhetate and its derivative, emulsifier, fat of Oromaius norvaehollandeae, penetrating agent, vitamin E, heat preservation is filled Divide stirring 20~40 minutes；Be cooled to 40~60 DEG C later, Baical Skullcap root P.E that addition is dissolved with cosolvent, phellodendron extract, Shrubby sophora extract, radix paeoniae alba extraction, Magnolia cortex P.E, Periostracum Serpentis extract, alkannin and menthol stir 10~30 minutes extremely It is sufficiently mixed, is eventually adding acid-base modifier, and supplement balance deionized water, be in pH between 5.5~7.5, be sufficiently stirred 10~30 minutes, cooling to obtain the final product.