CN103191232A - Traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle and preparation and application of composition - Google Patents
Traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle and preparation and application of composition Download PDFInfo
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- CN103191232A CN103191232A CN2013101248264A CN201310124826A CN103191232A CN 103191232 A CN103191232 A CN 103191232A CN 2013101248264 A CN2013101248264 A CN 2013101248264A CN 201310124826 A CN201310124826 A CN 201310124826A CN 103191232 A CN103191232 A CN 103191232A
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle. The traditional Chinese medicine composition is composed of coptis root, jasmine and gallnut in a weight ratio of 2: (2-4): (2-1), and the formulation is unique and satisfies the drug matching principle. Through the matching of the coptis root, jasmine and gallnut, the occlusion of papillary foramina can be strengthened to prevent pathogenic bacteria from passing the papillary foramina by virtue of the effects of clearing away heat and toxic materials and contracting smooth muscle of the jasmine. The invention further discloses a preparation containing the traditional Chinese medicine composition. The coptis root, jasmine fluid extract and gallnut fluid extract are combined, and then normal auxiliary materials are added to the combination to prepare the traditional Chinese medicine ointment. The preparation is a pure traditional Chinese medicine preparation with high security, is free of residues, and can be used in a lactation period; the preparation is applied to the papillary foramina so as to prevent the pathogenic bacteria from entering glandcistern from the papillary foramina; and meanwhile, the pathogenic bacteria in the papillary foramina and the glandcistern can be killed so as to effectively prevent mastitis of dairy cattle.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to Chinese medicine composition and the preparation thereof of preventing and treating mammitis of cow, also relate to the application of this Chinese medicine composition.
Background technology
Mastitis, namely milk is swollen, milk is yellow, acute mastitis, is that expectorant, wet, gas, blood stagnation knot do not loose, and changes and is due to the inflammation.It is reported that after milch cow had squeezed milk, teat sphincter was shunk fully and need be reached 1 hour, makes papillary foramina be in open state for a long time, provides convenience for pathogenic microorganism enters Ru Chi, therefore be considered to the one of the main reasons of mammitis of cow morbidity.Once there are a lot of raisers to prevent and treat in the papillary foramina administration with antimicrobial ointment season occurred frequently at mammitis of cow in the practice, but owing to be to use the non-dry milk phase, will certainly cause residues of antibiotics.Along with the raising of people to the attention degree of food safety, antibiotic is used for the control mammitis of cow and also is subjected to certain restriction.
Chinese medicine more and more is subjected to people's attention at the control mammitis of cow, also is the focus and emphasis of a lot of scholar's research, and the dosage form at the control mastitis has injection, injectable powder, liniment, unguentum etc. at present.But owing under blood breast barrier or the skin barrier effect, be difficult to reach active drug concentration in the newborn pond, therapeutic effect is often undesirable.In order to make medicine reach valid density at Ru Chizhong, also have in the prior art drug infusion in newborn pond, but adopt its operation of this mode administration very difficult, need professional person's professional tool.People such as Wang Jiufeng form thin film by " mastitis nipple Medicatedbath lotion " at body surface, thereby reach the effect of killing the papillary foramina pathogen that presses down, but milch cow is squeezing the milk cattle farm that can couch unavoidably in back 1 hour, will certainly cause breaking of thin film, a large amount of pathogenic microorganisms in the cattle bed can enter not closed fully papillary foramina again and cause morbidity in addition.In addition, clinical investigation finds that there is shortcomings such as using inconvenience, duration of efficacy weak point in the nipple Medicatedbath lotion.Therefore, develop a kind of control mammitis of cow medicine, can effectively stop pathogen to pass through papillary foramina, and can press down the important channel that the pathogen that kills in the papillary foramina is the control mammitis of cow.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Chinese medicine composition of preventing and treating mammitis of cow, prescription is unique, meets the drug matching principle, and is good to the prevention effect of mastitis.
For achieving the above object, the invention provides following technical scheme:
The Chinese medicine composition of control mammitis of cow, described Chinese medicine composition is made of for 2:2-4:2-1 by weight Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis.
Preferably, described Chinese medicine composition is made of for 2:2:1 by weight Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis.
Two of purpose of the present invention is to provide the preparation of control mammitis of cow, and its technical scheme is:
2. the preparation that contains described Chinese medicine composition.
Administration for convenience, most preferred dosage form is ointment, the ointment that makes can adopt the nipple administration, (pathogen enters the main path in newborn pond both can to have stoped pathogen to pass through open papillary foramina, can be long-time open because milch cow has squeezed the milk papillary foramina), can press down the cause of disease bacterium that kills in papillary foramina and the newborn pond again.
Preferably, described ointment comprises that percentage by weight is Rhizoma Coptidis, Fructus Gardeniae and the Galla Chinensis fluid extract of 10-15%.
Preferably, described ointment comprises that percentage by weight is 13% Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis fluid extract.
Preferred, the preparation method of Rhizoma Coptidis and Fructus Gardeniae fluid extract is: getting Rhizoma Coptidis and the Fructus Gardeniae of formula ratio, is 75% ethanol extraction with volume fraction, and extracting solution is concentrated into the medical material gross weight, gets alcohol extract; Medicinal residues extracting in water, extracting solution are concentrated into the medical material gross weight, get the water extract, merge alcohol extract and water extract then, concentrate, and get Rhizoma Coptidis and Fructus Gardeniae fluid extract.
Preferred, the preparation method of Rhizoma Coptidis and Fructus Gardeniae fluid extract is: get formula ratio Rhizoma Coptidis and Fructus Gardeniae, added the volume fraction be equivalent to 5 times of Rhizoma Coptidis and Fructus Gardeniae weight and be 75% soak with ethanol 30 minutes, be reflux, extract, 2 times under 80 ℃ of conditions in temperature then, each 1 hour, filtrate is concentrated into the medical material gross weight, gets alcohol extract; Add the water that is equivalent to 8 times of filtering residue weight in the filtering residue, heating extraction 3 times was extracted 1 hour at every turn, collect filtrate, and filtrate being concentrated into is equivalent to the medical material gross weight, get the water extract, merge alcohol extract and water extract then, and be concentrated into and be equivalent to the medical material gross weight, get Rhizoma Coptidis and Fructus Gardeniae fluid extract.
Preferably, the preparation method of Galla Chinensis fluid extract: get the Galla Chinensis of formula ratio, add the water that is equivalent to 15 times of Galla Chinensis weight, be to extract under 100 ℃ of conditions 2 times in temperature, each 2 hours, filtration collection filtrate was concentrated into then and is equivalent to Galla Chinensis weight, gets the Galla Chinensis fluid extract.
Three of purpose of the present invention is to provide the application of above-mentioned Chinese medicine composition, and technical scheme is:
The application of described Chinese medicine composition in the medicine of preparation control mammitis of cow.
Beneficial effect of the present invention is: the Chinese medicine composition of control mammitis of cow disclosed by the invention, and prescription is unique, has added Fructus Gardeniae in the prescription, has heat-clearing and toxic substances removing, shrink the effect of smooth muscle, can strengthen the closure of papillary foramina simultaneously, stop pathogen to enter papillary foramina; The invention also discloses Chinese medicine composition is made fluid extract, add conventional adjuvant then and make preparation (as ointment), can adopt the nipple administration, overcome employing intramuscular injection or quiet notes administration and can not effectively see through blood breast barrier, transdermal administration can not effectively pass through skin barrier, and can not make medicine reach the defective of valid density at Ru Chizhong, also having overcome breast perfusion preparation simultaneously needs operational difficulties such as professional person's professional tool; And use Chinese medicine ointment of the present invention, can make effective ingredient in the medicine enter in the newborn pond and reach active drug concentration, to preventing and treating the effective of mammitis of cow, owing to adopt ointment, have easy to usely, only need use several grams to get final product at every turn, and be convenient to remove, only needing milking is to extrude to discard to get final product, pollution-free to milk, can satisfy the needs of food safety.
The specific embodiment
With specific embodiment, be described in detail of the present invention below.
Embodiment 1
The Chinese medicine composition of control mammitis of cow, its prescription is as follows:
Prescription 1: Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis weight ratio are 2:2:1.
Prescription 2: Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis weight ratio are 2:2:2.
Prescription 2: Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis weight ratio are 2:4:1.
Embodiment 2
The preparation of Chinese medicine fluid extract
1. prepare Rhizoma Coptidis, Fructus Gardeniae fluid extract:
Get Rhizoma Coptidis and the Fructus Gardeniae of formula ratio respectively, added the volume fraction be equivalent to 5 times of Rhizoma Coptidis and Fructus Gardeniae weight and be 75% soak with ethanol 30 minutes, be reflux, extract, 2 times under 80 ℃ of conditions in temperature then, each 1 hour, filter and collect filtrate and filtering residue respectively, filtrate being concentrated into of collecting is equivalent to the medical material gross weight, is designated as filtrate A; The water that is equivalent to 8 times of filtering residue weight will be added in the filtering residue of collecting, heating extraction 3 times, the each extraction 1 hour, filter and collect filtrate, and filtrate being concentrated into be equivalent to the medical material gross weight, be designated as liquor B, then merging filtrate A and liquor B, and be concentrated into and be equivalent to the medical material gross weight, get Rhizoma Coptidis, Fructus Gardeniae fluid extract.
2. prepare the Galla Chinensis fluid extract
Getting the Galla Chinensis of formula ratio, add the water that is equivalent to 15 times of Galla Chinensis weight, is to extract 2 times under 100 ℃ of conditions in temperature, and each 2 hours, filtration collection filtrate was concentrated into then and is equivalent to Galla Chinensis weight, gets the Galla Chinensis fluid extract.
Rhizoma Coptidis, Fructus Gardeniae fluid extract and the Galla Chinensis fluid extract of preparation are mixed, get the Chinese medicine fluid extract.Be equivalent to the 1g crude drug in every 1mL Chinese medicine fluid extract in the gained Chinese medicine fluid extract.
Embodiment 3
The Chinese medicine ointment of control mammitis of cow, its preparation method can adopt the conventional method for preparing ointment, and method for optimizing is:
Get glycerol, triethanolamine, distilled water is as water, add benzoic acid then, nipalgin, during sodium sulfite and EDTA disodium are soluble in the aqueous phase, get hard ester acid then, lanoline, liquid paraffin, white vaseline is that 4:2.5:1.5:1 mixes the back as oil phase by mass ratio, mixed with water and heating in water bath to 85 ℃ carries out fusion with oil phase then, add sodium lauryl sulphate again, tween 80 and octadecanol are as emulsifying agent, speed with 80 ~ 100r/min stirs by same direction, get then in the adding of Chinese medicine fluid extract and substrate mixed liquor of formula ratio, mix homogeneously, condensation namely gets the Chinese medicine ointment of preventing and treating mammitis of cow.
In the Chinese medicine ointment of the control mammitis of cow that makes, the percentage by weight of Chinese medicine fluid extract is 15%, the percentage by weight of oil phase is 20%, the percentage by weight of emulsifying agent is 5%, the glycerol percentage by weight is 5%, the percentage by weight of triethanolamine is 1.489%, benzoic percentage by weight is 0.25%, the percentage by weight of nipalgin antiseptic is 0.1%, the percentage by weight of sodium sulfite is 0.5%, the percentage by weight of EDTA disodium is 0.01%, surplus is water, and wherein the HLB value of emulsifying agent is 13.
Further, the percentage by weight of Chinese medicine fluid extract is in the 10-15% scope, and emulsifying agent all can be made the Chinese medicine ointment of control mammitis of cow in the 3-5% scope.
Embodiment 4
Separate 4 strain mastitis pathogen (being respectively staphylococcus aureus, F group streptococcus, B streptococcus and D streptococcus) and 2 strain standard bacterium (for streptococcus (1886) and streptococcus (588)) from the cattle farm, Rongchang County and be strain subject, Chinese medicine fluid extract disclosed by the invention and 15 kinds of Chinese medicines are made extracting solution carry out extracorporeal bacteria inhibitor test, the result is as shown in table 1.
Table 1,15 kinds of Chinese medicine extraction liquid are to the MIC value (mg/mL) of main pathogen of bovine mastitis
| Chinese medicine | Staphylococcus aureus | The B streptococcus | The F streptococcus | The D streptococcus | Streptococcus type strain 1886 | Streptococcus type strain 588 |
| Rhizoma Coptidis | 2.0 | 31.3 | 62.5 | ＞500 | 62.5 | ＞500 |
| Galla Chinensis | 2.0 | 250 | 62.5 | 62.5 | 31.3 | 62.5 |
| Flos Lonicerae | ＞500 | 250 | 125 | 125 | 62.5 | 500 |
| Fructus Gardeniae | 250 | 125 | 62.5 | 125 | 62.5 | 2.0 |
| Radix Salviae Miltiorrhizae | 15.6 | ＞500 | 500 | ＞500 | 500 | 500 |
| Cortex Phellodendri | 2.0 | ＞500 | ＞500 | ＞500 | ＞500 | ＞500 |
| Herba Taraxaci | 62.5 | ＞500 | 500 | ＞500 | ＞500 | ＞500 |
| Pericarpium Granati | 31.3 | 500 | ＞500 | ＞500 | ＞500 | 500 |
| Radix Gentianae | 500 | ＞500 | ＞500 | ＞500 | ＞500 | ＞500 |
| Radix Scutellariae | 3.9 | ＞500 | ＞500 | ＞500 | ＞500 | 31.3 |
| Radix Et Rhizoma Rhei | 3.9 | 250 | 125 | 500 | ＞500 | 125 |
| The Fructus Chebulae | 31.3 | 250 | 62.5 | 500 | 250 | 250 |
| Cortex Fraxini | 31.3 | ＞500 | 2.0 | ＞500 | ＞500 | ＞500 |
| Radix Isatidis | 250 | ＞500 | ＞500 | ＞500 | ＞500 | ＞500 |
| Herba Taraxaci looses | 62.5 | ＞500 | 125 | ＞500 | ＞500 | 250 |
| The Chinese medicine fluid extract | 2.0 | 15.6 | 31.3 | 31.3 | 31.3 | 2.0 |
The result shows that in three kinds of Chinese medicines, Rhizoma Coptidis and Galla Chinensis are 2.0 mg/mL to staphylococcus aureus minimum inhibitory concentration (MIC); Galla Chinensis is 31.3mg/mL to streptococcus 1886 MIC; Fructus Gardeniae is 2.0mg/mL to streptococcus type strain 588 MIC; Rhizoma Coptidis is 2.0mg/mL to F streptococcus m IC; Galla Chinensis is 62.5mg/mL to D streptococcus m IC; Rhizoma Coptidis is 31.3mg/mL to B streptococcus m IC.But be to use the Chinese medicine fluid extract to carry out extracorporeal bacteria inhibitor test, many strains antibacterial MIC all had in various degree reduce.The result shows that the extract of Chinese medicine composition preparation disclosed by the invention has tangible inhibitory or killing effect to the mastitis pathogen, and effect is better than single medicine.
Explanation is at last, above preferred embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is described in detail by above preferred embodiment, but those skilled in the art are to be understood that, can make various changes to it in the form and details, and not depart from claims of the present invention institute restricted portion.
Claims (10)
1. prevent and treat the Chinese medicine composition of mammitis of cow, it is characterized in that: described Chinese medicine composition is made of for 2:2-4:2-1 by weight Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis.
2. according to the Chinese medicine composition of the described control mammitis of cow of claim 1, it is characterized in that: described Chinese medicine composition is made of for 2:2:1 by weight Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis.
3. the preparation that contains claim 1 or 2 described Chinese medicine compositions.
4. preparation according to claim 3, it is characterized in that: described preparation is ointment.
5. preparation according to claim 4, it is characterized in that: described ointment contains Rhizoma Coptidis, Fructus Gardeniae and the gallic fluid extract that percentage by weight is 10-15%.
6. preparation according to claim 5, it is characterized in that: described ointment comprises that percentage by weight is 13% Rhizoma Coptidis, Fructus Gardeniae and Galla Chinensis fluid extract.
7. according to claim 5 or 6 described preparations, it is characterized in that: the preparation method of Rhizoma Coptidis, Fructus Gardeniae fluid extract: getting Rhizoma Coptidis and the Fructus Gardeniae of formula ratio, is 75% ethanol extraction with volume fraction, and extracting solution is concentrated into the medical material gross weight, gets alcohol extract; Medicinal residues extracting in water, extracting solution are concentrated into the medical material gross weight, get the water extract, merge alcohol extract and water extract then, concentrate, and get Rhizoma Coptidis, Fructus Gardeniae fluid extract.
8. preparation according to claim 7, it is characterized in that: the preparation method of Rhizoma Coptidis, Fructus Gardeniae fluid extract is: get formula ratio Rhizoma Coptidis and Fructus Gardeniae, added the volume fraction be equivalent to 5 times of Rhizoma Coptidis and Fructus Gardeniae weight and be 75% soak with ethanol 30 minutes, be reflux, extract, 2 times under 80 ℃ of conditions in temperature then, each 1 hour, filtrate is concentrated into the medical material gross weight, gets alcohol extract; Add the water that is equivalent to 8 times of filtering residue weight in the filtering residue, heating extraction 3 times was extracted 1 hour at every turn, collect filtrate, and filtrate being concentrated into is equivalent to the medical material gross weight, get the water extract, merge alcohol extract and water extract then, and be concentrated into and be equivalent to the medical material gross weight, get Rhizoma Coptidis, Fructus Gardeniae fluid extract.
9. according to claim 5 or 6 described preparations, it is characterized in that: the preparation method of Galla Chinensis fluid extract: the Galla Chinensis of getting formula ratio, add the water that is equivalent to 15 times of Galla Chinensis weight, be to extract under 100 ℃ of conditions 2 times in temperature, each 2 hours, filtration collection filtrate is concentrated into then and is equivalent to Galla Chinensis weight, gets the Galla Chinensis fluid extract.
10. claim 1 or the 2 described Chinese medicine compositions application in the medicine of preparation control mammitis of cow.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878439A (en) * | 2016-06-02 | 2016-08-24 | 隆昌锐智恒创生物科技有限公司 | Traditional Chinese medicine spray film agent for preventing and treating cow mastitis and preparation method thereof |
| CN114848680A (en) * | 2021-02-03 | 2022-08-05 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
-
2013
- 2013-04-11 CN CN201310124826.4A patent/CN103191232B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 陈燕丽等: "中草药抗金黄色葡萄球菌的研究现状", 《中兽医医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878439A (en) * | 2016-06-02 | 2016-08-24 | 隆昌锐智恒创生物科技有限公司 | Traditional Chinese medicine spray film agent for preventing and treating cow mastitis and preparation method thereof |
| CN114848680A (en) * | 2021-02-03 | 2022-08-05 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
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| CN103191232B (en) | 2014-06-11 |
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Address after: 402460 Chongqing Changyuan County of Rongchang city Xueyuan Road street, No. 160 Patentee after: Southwest University Address before: 400715 Chongqing Road, Beibei District No. 2 Patentee before: Southwest University |