CN105641265A - Aloe combination drug used for treating acne, preparation thereof and application thereof - Google Patents
Aloe combination drug used for treating acne, preparation thereof and application thereof Download PDFInfo
- Publication number
- CN105641265A CN105641265A CN201610064624.9A CN201610064624A CN105641265A CN 105641265 A CN105641265 A CN 105641265A CN 201610064624 A CN201610064624 A CN 201610064624A CN 105641265 A CN105641265 A CN 105641265A
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- Prior art keywords
- radix
- aloe
- medicine
- composition
- volatile oil
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Abstract
The invention provides an aloe combination drug used for treating acne. The combination drug is prepared from aloe, radix lithospermi, grape seeds, polygonum cuspidatum, hlblSClls llutabilis, the root of red-rooted salvia, licorice roots, fructus forsythiae, mint, talcum powder, allantoin, clove oil and an active compound or extract of radix angelica sinensis volatile oil. According to the aloe combination drug used for treating acne and a cream preparation thereof, the combination drug has good itching relieving and inflammatory eliminating activity and is better than current common erythromycin ointment sold in the market.
Description
Technical field
The present invention relates to a kind of external medicine preparation, more specifically to a kind of Aloe composition of medicine for treating acne and preparation thereof.
Technical background
Acne is a kind of commonly encountered diseases, frequently-occurring disease, outside the Pass having with the factor such as endocrine, immunity, the mixed infection of the anaerobe such as hypersteatosis and hair follicle hyperkeratinization also assist in morbidity, propionibacterium acnes and the aerobe such as staphylococcus aureus, staphylococcus epidermidis is also closely related with it. Patients with acne skin lesion district, above-mentioned flora all enters to increase than health, propionibacterium acnes is the dominant bacteria of human body skin, owing to sebaceous gland growth is quick, sebum secretion is excessive, pilosebaceous duct dyskeratosis, sebum are discharged and be obstructed, propionibacterium acnes is able to growth and breeding under local anaerobic environment, causes hair follicle, sebaceous gland secondary infection. Prominent pathogenic of propionibacterium acnes has been found to, and can not only induce immunoreation and the local inflammation of body, also too fast relevant to hair follicle ductal epithelial cell hyperkeratosis. Propionibacterium acnes and the part aerobe growth and breeding such as staphylococcus aureus, staphylococcus epidermidis can be promoted again due to sebum drainage difficulty, cause inflamed papules, pustule. From theory of Chinese medical science, the factor such as the generation of acne and the foul damp of diseases caused by exogenous pathogenic factor, addiction delicious food savoury, eating and drinking without temperance or feelings will internal injury is relevant, and ferritic sun heat is contained partially in addition, throwing off restraint the product eating pungent delicious food, taste lose strong, grow turbid damp, accumulateing for a long time and turn to damp and hot turbid poison, pent-up head form acne. Its pathogeny is mainly the damp and hot poison stasis of blood combined into disease.
In commercially available acne external preparation, the Chinese herbal main component that compound tanshinone anti-acne glue contains is Radix Salviae Miltiorrhizae; Blue or green Cuo emulsifiable paste is made up of Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Angelicae Dahuricae, Bombyx Batryticatus, Borneolum Syntheticum etc. The combinational drug therapy acnes adopting Radix Salviae Miltiorrhizae to be monarch drug in the prior art more. It is made into by Fructus Cnidii, Aloe, Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Cordyceps, Ganoderma, Radix Glycyrrhizae, Flos Lonicerae etc. as Chinese patent application " Traditional Chinese medicine liniment (CN00123396.3) of a kind for the treatment of acne fast " provides for a kind of main formula. For treating the Chinese medicine composition of acne. In this formula, Fructus Cnidii, Aloe, Radix Salviae Miltiorrhizae and the Radix Rehmanniae are as monarch drug, the common active function playing bactericidal antiphlogistic. Chinese patent application " a kind of external Chinese medicinal liniment preventing and treating acne dermatosis and preparation method thereof (CN201110374815.2) " provides a kind of external medicine preparation being made up of Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Radix Scutellariae, Radix Hemsleyae Macrospermae, Aloe, Radix Glycyrrhizae and Borneolum Syntheticum, and in said preparation, Radix Sophorae Flavescentis and Radix Salviae Miltiorrhizae are main active as monarch drug.Chinese patent " tanshinone IIA purposes (CN201310023814.2) in the medicine or cosmetics of preparation suppression propionibacterium acnes " has opened tanshinone ��A for preparing prevention or treating the purposes in the medicine or cosmetics of being bred the acne caused by propionibacterium acnes.
Extracorporeal bacteria inhibitor test is the universal method checking titer of antibodies both at home and abroad, is also the method that specifies of pharmacopoeia of each country. The sensitivity measuring medicine is reacted by bacterium to be checked by the size of inhibition zone, and inhibition zone is more big, and MIC is more little, and the fungistatic effect of medicine is also more strong. This is it is demonstrated experimentally that main pathogenic bacterium of acnes group is had good inhibiting effect by compound tanshinone anti-acne glue, and the MIC to Cuo propionibacterium is 7.82, is 15.63��62.5 to staphylococcus epidermidis, the staphylococcic MIC of Fructus Citri Limoniae. The curative effect of Retinoids, Retin-A, Renova, Accutane needs many-sided overall merit, confirmed by this clinical observation on the therapeutic effect and antibacterial experiment in vitro, patients with acne skin lesion symptom is improved substantially by compound tanshinone anti-acne glue, and evident in efficacy, reliable, the discussion for its mechanism of action is that clinical application provides reliable foundation.
Summary of the invention
For solving the problems referred to above, the invention provides a kind of Aloe composition of medicine for treating acne, described composition of medicine by Aloe, Radix Arnebiae (Radix Lithospermi), Semen Vitis viniferae, Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae, Pulvis Talci, allantoin, Oleum Caryophylli and Radix Angelicae Sinensis volatile oil former medicine or extract form.
In described composition of medicine, the agents area of Aloe is the juice of fresh and alive Aloe, the agents area of Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae and Semen Vitis viniferae is water extract, the agents area of Oleum Caryophylli is the oil of Folium Caryophylli, flower or stem, Radix Angelicae Sinensis volatile oil with when the volatile oil of GUIQUAN medical material, Pulvis Talci and allantoin are for be all used as medicine.
In composition of medicine, the weight ratio of each component crude drug is: Aloe, Radix Arnebiae (Radix Lithospermi), Semen Vitis viniferae, Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae, Pulvis Talci, allantoin, Oleum Caryophylli, Radix Angelicae Sinensis volatile oil weight ratio be 20-30:2-5:5-10:10-20:5-10:5-10:1-5:5-10:1-5:2-5:1-5:1-5: 1-5;
Wherein, the weight of Aloe, Radix Arnebiae (Radix Lithospermi), Semen Vitis viniferae, Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae and Herba Menthae is the weight of crude drug, Oleum Caryophylli, Radix Angelicae Sinensis volatile oil the weight that weight is extractive of volatile oil, Pulvis Talci and allantoin are the medicine weight without any extraction process.
Wherein composition of medicine solid extract comprises the following steps:
1) weight ratio according to claim 3 weighs medical material, by Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae, Semen Vitis viniferae, adds 12 times of soak by water 3 times, each 1.5 hours, collecting decoction, filters, and is concentrated into appropriate, lets cool; Obtain extracting solution;
2) extracting solution is adjusted to containing determining alcohol 65% with 95% ethanol, stands 24 hours, take supernatant, reclaim ethanol to without alcohol taste, 80 DEG C of drying under reduced pressure, obtaining dry extract;
3) adding Talcum powder in dry extract, allantoin powder obtains composition of medicine solid extract.
For the preparation method treating the Aloe combined pharmaceutical formulation of acne, comprise the following steps:
1) according to Aloe, Radix Arnebiae (Radix Lithospermi), Semen Vitis viniferae, Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae, Pulvis Talci, allantoin, Oleum Caryophylli, Radix Angelicae Sinensis volatile oil, stearic acid, vaseline, lanoline, hexadecanol, glycerol monostearate vinegar, sodium lauryl sulphate, glycerol and the weight ratio that light yl benzoic acid second vinegar is 20-30:2-5:5-10:10-20:5-10:5-10:1-5:5-10:1-5:2-5:1-5:1-5: 1-5:1-3:5-10:2-8:2-8:1-5:1-3:10-20:0.2-0.5 is weighed medical material and adjuvant,
2) by stearic acid, vaseline, lanoline, hexadecanol, glycerol monostearate vinegar, Oleum Caryophylli and Radix Angelicae Sinensis volatile oil, heating, to 85 DEG C, stirs evenly, as oil phase, standby;
3) by sodium lauryl sulphate, glycerol, to light yl benzoic acid second vinegar, add dry extract and fresh aloe juice, water use regulation heats to 90 DEG C, and after all dissolving, constant temperature, to 85 DEG C, stirs evenly, as aqueous phase;
4) oil phase is slowly added into aqueous phase, puts 1000rpm in refiner and stir 15min, cooling, solidification, subpackage, obtain the Aloe combined pharmaceutical formulation for treating acne.
The Aloe composition of medicine for treating acne described above application in preparing Retinoids, Retin-A, Renova, Accutane.
The method have the benefit that: the invention provides a kind of Aloe composition of medicine for treating acne and cream preparation thereof, the drug regimen that this preparation provides has the excellent activity of itch stopping and diminish inflammation, is better than commonly using commercially available erythromycin ointment at present.
Detailed description of the invention
The bacteriostatic activity research of the different Aloe composition of medicine of embodiment 1
1, strain:
Bacterial strain propionibacterium acnes reference culture ATCC1l827, staphylococcus aureus reference culture ATCC100817.
2, reagent:
Propionibacterium acnes culture medium; Brain-heart infusion medium; Staphylococcus aureus: Carnis Bovis seu Bubali cream culture medium.
Culture medium is prepared according to a conventional method, and adjusting pH value is 7.1��7.2. To cultivate based on after good seal in conical flask, and put in autoclave sterilizing 30min at 121 DEG C, after cooling, be placed in 4 DEG C of refrigerators and save backup.
Reference culture inoculated and cultured respectively is increased bacterium by the preparation of bacteria suspension, cultivating 24h (propionibacterium acnes anaerobism glove box cultivates 48h) under conventional culture conditions, absorption bacterium solution culture medium dilution is adjusted to 0.5 Maxwell and (is about 1.5 �� 10 than turbid unit8CFU/mL), bacteria suspension culture medium is continued dilution, 1 �� 10 will be adjusted to Maxwell than turbid instrument5��106CFU/mL, standby.
3, prepared by test liquid:
The preparation of 3.1 experimental group A
Weigh Aloe 20 parts, Radix Arnebiae (Radix Lithospermi) 2 parts, Semen Vitis viniferae 5 parts, Rhizoma Polygoni Cuspidati 10 parts, Flos Hibisci Mutabilis 5 parts, Radix Salviae Miltiorrhizae 5 parts, 1 part of Radix Glycyrrhizae, Fructus Forsythiae 5 parts, Herba Menthae 1 part, Pulvis Talci 2 parts, allantoin 1 part, Oleum Caryophylli 1 part, Radix Angelicae Sinensis volatile oil 1 part;
Undertaken Aloe removing the peel, grinding process, carry out sterilization after grinding, then aseptically separated by gravy, it is thus achieved that the fresh juice of organic aloe.
Take Rhizoma Polygoni Cuspidati, Radix Arnebiae (Radix Lithospermi), Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae and Semen Vitis viniferae fine powder and add 12 times of soak by water 3 times, each 1.5 hours, collecting decoction, filter, be concentrated into appropriate, let cool. Add 95% ethanol to alcohol content and reach 65%, stand 24 hours, take supernatant, reclaim ethanol to without alcohol taste, 80 DEG C of drying under reduced pressure, obtain dry extract, add Pulvis Talci (powder) 2 parts, allantoin (powder) 2 parts, puts in exsiccator, obtains medicine dried cream powder.
Weigh stearic acid 1 part, 10 parts of vaseline, lanoline 8 parts, hexadecanol 8 parts, glycerol monostearate vinegar 4 parts, add Oleum Caryophylli and Radix Angelicae Sinensis volatile oil. Heating, to 85 DEG C, stirs evenly, as oil phase, standby.
Separately take sodium lauryl sulphate 2 parts, glycerol 12 parts, to light yl benzoic acid second vinegar 0.2 part, add medicine dry extract and fresh aloe juice, water use regulation makes biphase totally 200 parts of oil, water. Heating is to 90 DEG C, and after all dissolving, constant temperature, to 85 DEG C, stirs evenly, as aqueous phase.
Oil phase is slowly added into aqueous phase, puts stirring (looorpm, 15min) in refiner, cooling, solidification, subpackage, obtain Aloe combined pharmaceutical formulation, give experimental group A by name;
The preparation of 3.2 experimental group B
Weigh Aloe 30 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Semen Vitis viniferae 10 parts, Rhizoma Polygoni Cuspidati 20 parts, Flos Hibisci Mutabilis 10 parts, Radix Salviae Miltiorrhizae 10 parts, 5 parts of Radix Glycyrrhizae, Fructus Forsythiae 10 parts, Herba Menthae 5 parts, Pulvis Talci 5 parts, allantoin 5 parts, Oleum Caryophylli 5 parts, Radix Angelicae Sinensis volatile oil 5 parts. Prepare Aloe combined pharmaceutical formulation according to the method described above, give experimental group B by name;
The preparation of 3.3 experimental group C
Weigh Aloe 25 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Semen Vitis viniferae 7 parts, Rhizoma Polygoni Cuspidati 15 parts, Flos Hibisci Mutabilis 8 parts, Radix Salviae Miltiorrhizae 8 parts, 4 parts of Radix Glycyrrhizae, Fructus Forsythiae 7 parts, Herba Menthae 4 parts, Pulvis Talci 3 parts, allantoin 4 parts, Oleum Caryophylli 4 parts, Radix Angelicae Sinensis volatile oil 4 parts. Prepare Aloe combined pharmaceutical formulation according to the method described above, give experimental group C by name;
The preparation of 3.4 experimental group D
By the above-mentioned experimental group A medicine dried cream powder obtained, add Oleum Caryophylli and Radix Angelicae Sinensis volatile oil, mix well with distilled water, give experimental group D by name;
The preparation of 3.5 experimental group E
By the above-mentioned experimental group B medicine dried cream powder obtained, add Oleum Caryophylli and Radix Angelicae Sinensis volatile oil, mix well with distilled water, give experimental group E by name;
The preparation of 3.6 experimental group F
By the above-mentioned experimental group C medicine dried cream powder obtained, add Oleum Caryophylli and Radix Angelicae Sinensis volatile oil, mix well with distilled water, to name experimental group F.
Inhibition zone measures
Under aseptic technique, take above-mentioned bacteria suspension respectively, with spreading rod uniform application in culture medium. Putting down Oxford cup gently media surface in solidification with aseptic tweezer again, light pressure Oxford cup makes contact good. Drawing test liquid in the cup of Oxford with injection needles, 37 DEG C of incubators take out (propionibacterium acnes anaerobism glove box cultivates 48h) after cultivating 24h, accurately measure the diameter of the effective inhibition zone of test liquid in each culture dish with slide calliper rule. Each sample repeats 3 times. Additionally prepare matched group: blank group (culture medium), negative control group (culture medium, bacteria suspension, sterilized water), positive controls (culture medium, bacteria suspension, erythromycin), observe the impact on bacterial growth of the growing state of antibacterial, culture medium and Chinese herbal medicine. Concrete as shown in table 1.
The table 1 various extract suppression circle (n=3) to acne pathogenic bacterium
Note: for 3 repeated experiments average result, "-" indicates without obvious inhibition zone
Statistical conclusions from table 1 is not it is found that the multipair propionibacterium acnes of the extract of Radix Arnebiae (Radix Lithospermi) possesses activity, and the mixing fungistatic effect being made up of Radix Salviae Miltiorrhizae, Radix Arnebiae (Radix Lithospermi), Aloe and Herba Menthae etc. is ideal; Wherein close to the activity of erythromycin in the activity to propionibacterium acnes.
Minimal inhibitory concentration (MIC) measures
Adopt 2 times of dilution methods of test tube, measure above-mentioned each group of test liquid minimal inhibitory concentration (MIC). The Chinese medicine test liquid fluid medium of fungistatic effect all there are to dilute l0,20,40,80,160,320,640,1280 and 2560 times successively two kinds of pathogenic bacterium in above-mentioned inhibition zone measures. I.e. concentration respectively lOOmg/mL, 50mg/mL, 25mg/mL, 12.5mg/mL, 6.25mg/mL, 3.125mg/mL, 1.5625mg/mL, 0.7825mg/mL, 0.3913mg/mL of final medicinal liquid (crude drug content). The diluent of lmL adds the bacteria suspension of 0.1mL. And set positive control pipe. Cultivate 24h (propionibacterium acnes anaerobism glove box cultivates 48h), observed result for 37 DEG C. The experiment tube of minimum diluent concentration is found out, it is determined that MIC from each pipe of asepsis growth; Specifically it is shown in Table 2.
The extract MIC (mg/mL) (�� s) to acne pathogenic bacterium respectively organized by table 2
Note: be the meansigma methods repeating experiment for 3 times.
Embodiment 2 is treated the Aloe combined pharmaceutical formulation of acne and is investigated at pharmacodynamics
Anti-inflammation test: adopt mice ear method, choose SD rat 60, male and female half and half, body weight 180-220g. 6O Mus is randomly divided into 6 groups, often group 10, i.e. blank group, experimental group A, B, C and positive drug control group. Experimental group A, B, C are equivalent to the preparation of crude drug amount 1.5g respectively to mouse right ear, and positive controls smears commercially available erythromycin ointment 0.2g at mouse right ear; Blank group does not deal with, and is applied to each group of mouse right ear with dimethylbenzene (0.03mL/ is only) and causes inflammation after 30min, and after 15min, de-cervical vertebra puts to death mice, lays round auricle at the same position of ear, left and right two respectively with 8mm diameter card punch. Weighing in electronic analytical balance, every Mus auris dextra sheet weight deducts left auricle weight and is this Mus inflammatory tissue swelling, and medicine group ear swelling degree compares with blank group.
The result of each group mouse corrosion disease test, is shown in Table 3; Each group mice caused by dimethylbenzene xylene inflammation ear swelling degree is significantly less than blank group, and difference has highly significant (P < 0.01), illustrates that each group of the Aloe composition of medicine emulsifiable paste for the treatment of acne has antiinflammatory action.
The impact on mice swelling of the Aloe composition of medicine emulsifiable paste of acne treated by table 3
Note: compare with blank group,*P 0.01;
Antipruritic test: Cavia porcellus is randomly divided into by body weight, sex administration group and matched group. It is randomly divided into 6 groups, often group 10, male and female half and half, i.e. blank group, experimental group A, B, C and positive drug control group. Experimental group A, B, C obtain preparation at Cavia porcellus auris dextra auricle uniform application experimental group A, B, C obtained above respectively and are equivalent to 1.5 (crude drug) g kg-1, positive controls is at Cavia porcellus auris dextra auricle uniform application erythromycin emulsifiable paste 2.0g kg-1, acne ointment matched group 2.0g kg-1 that commercially available acne ointment (the quasi-word B20050043 of traditional Chinese medicines) obtains at Cavia porcellus auris dextra auricle uniform application, blank group is at Cavia porcellus auris dextra auricle uniform application bare substrate 2.0g kg-1, 2 times/d, 1d before experiment, to instep shaving behind each group of Cavia porcellus right side, and coating 1 time. Et is worked as in experiment, and with shaving place, instep behind No. 0 sand paper scratch animal right side, with a small amount of oozing of blood for degree, area is 1cm2, local coating again is once. 10min after last administration. Beginning at wound surface place with 0.O1% histamine phosphate 0.05mL/ only to drip, each interval time is 3min, until occurring that Cavia porcellus later licks right metapedes, to start histamine phosphate's total amount itch-threshold the most that Cavia porcellus gives when later licking right metapedes occur. Record and more each group cause Fujian of itching, between organizing t inspection. result is in Table 4. As seen from Table 4, experimental group A, B, C compare with blank group, difference statistically significant (P < 0.05 or P < 0.01). Experimental group A, B, to improving playing a role clearly of histamine phosphate itch-threshold, illustrate that the Aloe composition of medicine emulsifiable paste for the treatment of acne is remarkably improved the histamine phosphate itch-threshold to Cavia porcellus.
Table 4 is treated the Aloe composition of medicine emulsifiable paste of acne and histamine phosphate is caused the impact (�� SD, n=10) of foot pruritus
Note: compare with blank group,*P is < O.05,#P<O.O1��
Claims (6)
1. the Aloe composition of medicine being used for treating acne, it is characterised in that: described composition of medicine is made up of former medicine or the extract of Aloe, Radix Arnebiae (Radix Lithospermi), Semen Vitis viniferae, Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae, Pulvis Talci, allantoin, Oleum Caryophylli and Radix Angelicae Sinensis volatile oil.
2. the Aloe composition of medicine for treating acne according to claim 1, it is characterized in that: in described composition of medicine, the agents area of Aloe is the juice of fresh and alive Aloe, the agents area of Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae and Semen Vitis viniferae is water extract, the agents area of Oleum Caryophylli is the oil of Folium Caryophylli, flower or stem, the agents area of Radix Angelicae Sinensis volatile oil is the volatile oil when GUIQUAN medical material, and Pulvis Talci and allantoin are for be all used as medicine.
3. the Aloe composition of medicine for treating acne according to claim 2, it is characterised in that: in composition of medicine, the weight ratio of each component crude drug is: Aloe, Radix Arnebiae (Radix Lithospermi), Semen Vitis viniferae, Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae, Pulvis Talci, allantoin, Oleum Caryophylli, Radix Angelicae Sinensis volatile oil weight ratio be 20-30:2-5:5-10:10-20:5-10:5-10:1-5:5-10:1-5:2-5:1-5:1-5: 1-5;
Wherein, the weight of Aloe, Radix Arnebiae (Radix Lithospermi), Semen Vitis viniferae, Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae and Herba Menthae is the weight of crude drug, Oleum Caryophylli, Radix Angelicae Sinensis volatile oil the weight that weight is extractive of volatile oil, Pulvis Talci and allantoin are the medicine weight without any extraction process.
4. the preparation method for treating the Aloe composition of medicine of acne, it is characterised in that: wherein composition of medicine solid extract comprises the following steps:
1) weight ratio according to claim 3 weighs medical material, by Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae, Semen Vitis viniferae, adds 12 times of soak by water 3 times, each 1.5 hours, collecting decoction, filters, and is concentrated into appropriate, lets cool; Obtain extracting solution;
2) extracting solution is adjusted to containing determining alcohol 65% with 95% ethanol, stands 24 hours, take supernatant, reclaim ethanol to without alcohol taste, 80 DEG C of drying under reduced pressure, obtaining dry extract;
3) adding Talcum powder in dry extract, allantoin powder obtains composition of medicine solid extract.
5. the preparation method for treating the Aloe combined pharmaceutical formulation of acne, it is characterised in that: comprise the following steps:
1) according to Aloe, Radix Arnebiae (Radix Lithospermi), Semen Vitis viniferae, Rhizoma Polygoni Cuspidati, Flos Hibisci Mutabilis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Forsythiae, Herba Menthae, Pulvis Talci, allantoin, Oleum Caryophylli, Radix Angelicae Sinensis volatile oil, stearic acid, vaseline, lanoline, hexadecanol, glycerol monostearate vinegar, sodium lauryl sulphate, glycerol and the weight ratio that light yl benzoic acid second vinegar is 20-30:2-5:5-10:10-20:5-10:5-10:1-5:5-10:1-5:2-5:1-5:1-5: 1-5:1-3:5-10:2-8:2-8:1-5:1-3:10-20:0.2-0.5 is weighed medical material and adjuvant,
2) by stearic acid, vaseline, lanoline, hexadecanol, glycerol monostearate vinegar, Oleum Caryophylli and Radix Angelicae Sinensis volatile oil, heating, to 85 DEG C, stirs evenly, as oil phase, standby;
3) by sodium lauryl sulphate, glycerol, to light yl benzoic acid second vinegar, add dry extract and fresh aloe juice, water use regulation heats to 90 DEG C, and after all dissolving, constant temperature, to 85 DEG C, stirs evenly, as aqueous phase;
4) oil phase is slowly added into aqueous phase, puts 1000rpm in refiner and stir 15min, cooling, solidification, subpackage, obtain the Aloe combined pharmaceutical formulation for treating acne.
6. the application in preparing Retinoids, Retin-A, Renova, Accutane of the Aloe composition of medicine for treating acne described in any one of claim 1,3.
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| CN201610064624.9A CN105641265A (en) | 2016-01-29 | 2016-01-29 | Aloe combination drug used for treating acne, preparation thereof and application thereof |
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| CN201610064624.9A CN105641265A (en) | 2016-01-29 | 2016-01-29 | Aloe combination drug used for treating acne, preparation thereof and application thereof |
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| CN105641265A true CN105641265A (en) | 2016-06-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610064624.9A Withdrawn CN105641265A (en) | 2016-01-29 | 2016-01-29 | Aloe combination drug used for treating acne, preparation thereof and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974995A (en) * | 2017-04-26 | 2017-07-25 | 重庆市中药研究院 | One kind is used for Hirudo japonica externally applied compound medicinal, preparation and its application |
| CN107334912A (en) * | 2017-08-30 | 2017-11-10 | 南京多宝生物科技有限公司 | The extracting method and aloe products of a kind of aloe |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142456A (en) * | 2013-03-27 | 2013-06-12 | 王付喜 | Traditional Chinese medicine acne removing face cream |
| CN103599181A (en) * | 2013-11-29 | 2014-02-26 | 苏国仁 | Medicine for treating acne |
-
2016
- 2016-01-29 CN CN201610064624.9A patent/CN105641265A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142456A (en) * | 2013-03-27 | 2013-06-12 | 王付喜 | Traditional Chinese medicine acne removing face cream |
| CN103599181A (en) * | 2013-11-29 | 2014-02-26 | 苏国仁 | Medicine for treating acne |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974995A (en) * | 2017-04-26 | 2017-07-25 | 重庆市中药研究院 | One kind is used for Hirudo japonica externally applied compound medicinal, preparation and its application |
| CN107334912A (en) * | 2017-08-30 | 2017-11-10 | 南京多宝生物科技有限公司 | The extracting method and aloe products of a kind of aloe |
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Application publication date: 20160608 |