CN103585330B - A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof - Google Patents
A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition for cutaneous fungal infection, it is made up of the crude drug of following weight portion: Fructus Toosendan 10-30 part, Cortex Phellodendri 10-30 part, Flos Carthami 5-25 part and Folium Artemisiae Argyi 15-40 part.Chinese medicine composition of the present invention belongs to external anti-fungal infection medicine, use safety, Be very effective.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Along with the antibiotic extensive use of high-efficiency broad spectrum, diabetes and acquired immune deficiency syndrome (AIDS) patient are on the increase, and the sickness rate of fungal infection presents ascendant trend.Medical circle is devoted to find effective, safe antifungal drug always.Chinese herbal medicine is one of precious wealth in motherland's medical treasure-house, has a lot of active strong, effective ingredient that toxicity is low, have certain antibacterial, bactericidal action to common pathogen in Chinese herbal medicine.Research and develop multiple antifungal Chinese medicine and have important meaning to solution Resistant strain problem.
The Chinese medicine preparation made of general Chinese herbal medicine due to the chemical property difference of various antibiotic effective ingredient comparatively large, be difficult to the fungus being applied to deep skin, often effective rear easy recurrence, can not effect a radical cure.
Therefore invention is a kind of safe and effective, especially has the Chinese medicine composition of good action to be necessary and feasible to deep skin fungal infection.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of safe, effective, economic Chinese medicine composition for cutaneous fungal infection.
The present invention forms for the crude drug of antifungal Chinese medicine composition primarily of following weight portion: Fructus Toosendan 10-30 part, Cortex Phellodendri 10-30 part, Flos Carthami 5-25 part and Folium Artemisiae Argyi 15-40 part.
Preferably, each crude drug and weight portion thereof are respectively: Fructus Toosendan 15-25 part, Cortex Phellodendri 15-25 part, Flos Carthami 10-20 part and Folium Artemisiae Argyi 20-35 part.
More preferably, each crude drug and weight portion thereof are respectively: Fructus Toosendan 20 parts, Cortex Phellodendri 20 parts, 15 parts, Flos Carthami and Folium Artemisiae Argyi 30 parts.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, the method comprises the steps: 1) Flos Carthami powder is broken to 60-300 order, all the other flavour of a drug are crushed to 30 ~ 120 orders, the glacial acetic acid lixiviate of 5-8 times amount 5-30% 2-3 time, soak 7 days for 1st time, soak 3-5 days 2nd time and 3 times, filter, concentrate, obtain concentrated solution;
2) concentrated solution is added pharmaceutically acceptable carrier and/or excipient, make ointment, solution, patch, cream, aerosol agent, paste, plaster, external pulvis etc.
Preferably, the preparation method of this Chinese medicine composition is:
1) Flos Carthami powder is broken to 80-200 order, and all the other flavour of a drug are crushed to 30 ~ 70 orders, with the glacial acetic acid lixiviate 2 times of envelope-bulk to weight ratio 6 times amount 10%, soaks 7 days for the 1st time, soaks 5 days for the 2nd time, filter, concentrated, obtains concentrated solution;
2) above-mentioned concentrated solution is added pharmaceutically acceptable carrier and/or excipient, make ointment, solution, patch, cream, aerosol agent, paste, plaster, external pulvis etc.
More have choosing, the preparation method of this Chinese medicine composition is:
1) Flos Carthami powder is broken to 120 orders, and all the other flavour of a drug are crushed to 60 orders, with the glacial acetic acid lixiviate 3 times of envelope-bulk to weight ratio 6 times amount 10%, soaks 7 days for the 1st time, respectively soaks 3 days for the 2nd time and the 3rd time, filters, concentrates, obtain concentrated solution;
3) glacial acetic acid of 10% is mixed with composition concentrated solution in right amount, add pharmaceutically acceptable carrier and/or excipient, make ointment, solution, patch, cream, aerosol agent, paste, plaster, external pulvis etc.
Of the present invention is external preparation, and through the Chinese medicine ingredients that glacial acetic acid extracts, chemical property is more single, and purity is higher, can kill deep skin fungus.Glacial acetic acid contained in this preparation improves the sterilizing function of Chinese medicine composition by the effect such as softening skin and exfoliation, has collaborative antifungic action with Chinese medicine composition.
Cortex Phellodendri in prescription: can heat-clearing and toxic substances removing, dampness removing to stop itchin and parasite killing etc. be monarch drug; Fructus Toosendan: soothing liver-QI expels the heat-evil, anthelmintic, Folium Artemisiae Argyi: removing dampness to relieve itching, warm both QI and blood are ministerial drug; Flos Carthami, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain are adjuvant drug, strengthen lesions position qi and blood circulation, make metabolism vigorous, evil malicious loss, recover its self-defence defence capability, thus realize the object for the treatment of both the principal and secondary aspects of a disease.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
Prescription forms:
Fructus Toosendan 2kg, Cortex Phellodendri 2kg, Flos Carthami 1.5kg and Folium Artemisiae Argyi 3kg
The preparation method of unguentum:
1) Flos Carthami powder is broken to 120 orders, and all the other flavour of a drug are crushed to 60 orders, obtains the medicated powder of ingredients;
2) with 10% glacial acetic acid lixiviate 3 times, soak 7 days for the 1st time, the 2nd time and the 3rd each immersion 3 days, filtering, being concentrated into relative density is 1.20-1.30(25 DEG C), obtain concentrated solution.
3) by Chinese medicine composition concentrated solution, the vaseline of 85% and mixture, the Nipagin ester of 15% lanoline, 10% glacial acetic acid mixes in the ratio of 3:5:1:1, makes homogeneous external ointment for skin.
Experimental example 1: the clinical trial of antibacterial Chinese medicine compositions of the present invention
1. clinical data
Case selection: select beriberi patient 50 example: man 25 example, female 25 example; Tinea corporis 42 example, man 20 example, female 22 example; Prurigo 45 example man 30 example, female 15 example, respectively the external application embodiment of the present invention 1 ointment, general clinical data is in table 1
The general clinical data of table 1.
2. Therapeutic Method
2.1 embodiment of the present invention 1 ointments are applied to affected part equably, change dressings once every 2 ~ 3 days, within 5 days, are a course for the treatment of.
3. criterion of therapeutical effect
Cure: without pruritus, inflammation disappears; Skin lesion place is as excellent as before, without leaving a trace.
Effective: to have micro-redness, affected part area reduces more than 2/3;
Invalid: original symptom does not change.
4. therapeutic outcome and conclusion (see table 2).
The present invention is by the treatment to 137 routine patients, and total effective rate 100%, cure rate 79.6%, effective percentage 20.4%, the present invention is to beriberi, and tinea corporis, prurigo have obvious therapeutic effect.
Table 2 Chinese medicine composition is to the therapeutic effect of different fungal infection disease
Claims (6)
1. be used for the treatment of a Chinese medicine composition for cutaneous fungal infection, its crude drug is the medical material of following weight portion: Fructus Toosendan 10-30 part, Cortex Phellodendri 10-30 part, Flos Carthami 5-25 part and Folium Artemisiae Argyi 15-40 part.
2. Chinese medicine composition according to claim 1, is characterized in that, its crude drug is the medical material of following weight portion: Fructus Toosendan 15-25 part, Cortex Phellodendri 15-25 part, Flos Carthami 10-20 part and Folium Artemisiae Argyi 20-35 part.
3. Chinese medicine composition according to claim 2, is characterized in that, its crude drug is the medical material of following weight portion: Fructus Toosendan 20 parts, Cortex Phellodendri 20 parts, 15 parts, Flos Carthami and Folium Artemisiae Argyi 30 parts.
4. a preparation method for Chinese medicine composition described in any one of claim 1-3, is characterized in that, comprise the steps:
1) Flos Carthami powder is broken to 60-300 order, and all the other flavour of a drug are crushed to 30 ~ 120 orders, with glacial acetic acid lixiviate 2-3 time of envelope-bulk to weight ratio 5-8 times amount 5-30%, soaks 7 days for the 1st time, soaks 3-5 days later at every turn, filters, concentrated, obtains concentrated solution;
2) concentrated solution is added pharmaceutically acceptable carrier and/or excipient, make ointment, solution, patch, cream, aerosol agent, paste, plaster, external pulvis.
5. the preparation method of Chinese medicine composition according to claim 4, is characterized in that, comprises the steps:
1) Flos Carthami powder is broken to 80-200 order, and its pleasant impression medicated powder is broken to 30 ~ 70 orders, with the glacial acetic acid lixiviate 2 times of envelope-bulk to weight ratio 6 times amount 10%, soaks 7 days for the 1st time, soaks 5 days for the 2nd time, filter, concentrated, obtains concentrated solution;
2) above-mentioned concentrated solution is added pharmaceutically acceptable carrier and/or excipient, make ointment, solution, patch, cream, aerosol agent, paste, plaster, external pulvis.
6. be used for the treatment of a preparation method for the pharmaceutical composition of cutaneous fungal infection, it is characterized in that, raw material of Chinese medicine medicine is the medical material of following weight portion: Fructus Toosendan 10-30 part, Cortex Phellodendri 10-30 part, Flos Carthami 5-25 part and Folium Artemisiae Argyi 15-40 part; Described preparation method comprises the steps:
1) Flos Carthami powder is broken to 120 orders, all the other flavour of a drug are crushed to 60 orders, with the glacial acetic acid lixiviate 3 times of envelope-bulk to weight ratio 6 times amount 10%, soak 7 days for the 1st time, respectively soak 3 days for the 2nd time and the 3rd time, filter, concentrate, obtain concentrated solution;
2) glacial acetic acid of 10% is mixed with concentrated solution, add pharmaceutically acceptable carrier and/or excipient, make ointment, solution, patch, cream, aerosol agent, paste, plaster, external pulvis.
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| CN201310500888.0A CN103585330B (en) | 2013-10-22 | 2013-10-22 | A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof |
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| CN201310500888.0A CN103585330B (en) | 2013-10-22 | 2013-10-22 | A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof |
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| CN103585330A CN103585330A (en) | 2014-02-19 |
| CN103585330B true CN103585330B (en) | 2015-08-05 |
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| CN108079105A (en) * | 2017-05-22 | 2018-05-29 | 安徽菩提生物医药科技有限公司 | A kind of composition of skin bacteria inhibitor of external application and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1718226A (en) * | 2005-05-09 | 2006-01-11 | 汪建国 | Medicine composition for treating leuconychia, and its prepn. method |
| CN101695514A (en) * | 2009-10-30 | 2010-04-21 | 邯郸钢铁股份有限公司 | Traditional Chinese medicinal preparation for treating trauma and cicatricial hyperplasia gargalesthesia and preparation method thereof |
| US8476486B2 (en) * | 2009-07-29 | 2013-07-02 | California Oils Corporation | Ramularia leaf spot resistant safflower |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1718226A (en) * | 2005-05-09 | 2006-01-11 | 汪建国 | Medicine composition for treating leuconychia, and its prepn. method |
| US8476486B2 (en) * | 2009-07-29 | 2013-07-02 | California Oils Corporation | Ramularia leaf spot resistant safflower |
| CN101695514A (en) * | 2009-10-30 | 2010-04-21 | 邯郸钢铁股份有限公司 | Traditional Chinese medicinal preparation for treating trauma and cicatricial hyperplasia gargalesthesia and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 天然防腐剂的防腐机理及抑菌效果研究现状;王文光等;《农产品加工 学刊》;20120831(第8期);第107-109页，尤其是第108页右栏第3段 * |
| 自制去扁平疣便方;刘正才等;《家庭医生报》;20071015;第1页第5段 * |
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