CN108379347A - A kind of hemp floral leaf anti-inflammatory analgetic ointment and preparation method thereof - Google Patents
A kind of hemp floral leaf anti-inflammatory analgetic ointment and preparation method thereof Download PDFInfo
- Publication number
- CN108379347A CN108379347A CN201810416392.8A CN201810416392A CN108379347A CN 108379347 A CN108379347 A CN 108379347A CN 201810416392 A CN201810416392 A CN 201810416392A CN 108379347 A CN108379347 A CN 108379347A
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- Prior art keywords
- floral leaf
- inflammatory analgetic
- hemp floral
- extract
- vaseline
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
Abstract
The invention discloses a kind of hemp floral leaf anti-inflammatory analgetic ointment and preparation method thereof, in parts by weight, including the following raw material：Industrial hemp floral leaf extract 10~60%, vaseline 20~40%, paraffin 10~35%, transdermal enhancer 5~18%, auxiliary material 0.1~5%.Anti-inflammatory analgetic ointment of the present invention uses all natural industrial hemp floral leaf extract, in conjunction with other matching components, anti-inflammatory analgetic effect is apparent, also there is certain anti-microbial property, and the pharmacological property ingredient in this product can be with rapid osmotic skin, the acute pains of injury such as the either chronic aches such as arthralgia, or strain all have stronger analgesia, detumescence, anti-inflammatory efficacy.The anti-inflammatory analgetic ointment of the present invention is easily fabricated, and preparation method technology degree is high, and cost is relatively low, is suitble to large-scale production.
Description
Technical field
The invention belongs to relieve pain, anti-inflammatory pharmaceutical technology field, and in particular to a kind of hemp floral leaf anti-inflammatory analgetic ointment
And preparation method thereof.
Background technology
In daily life, with modern society's working environment, the change of rhythm of life, caused by various factors
Traumatic injury, soreness of waist and knee joint influence people's health and daily life and work.Regular western medicine treatment is only simple wound
Disposition and symptomatic treatment mostly locally or systemically use analgesic-antipyretic, alleviate inflammation in the short time in addition to local use local anaesthetics
And pain, local skin stimulation and gastrointestinal side effect are often resulted in, and though markedly fast, it is palliative, soft tissue is damaged
Wound can only lean on the natural reparation of body, and thoroughly there is still a need for the long periods for recovery from illness.
Many external preparations on the market have effects that analgesia, analgesic, detumescence at present, and formula components are different, effect
Different from, all different for different injuries and its processing method of disease and medication, effect is also unsatisfactory, and is permitted
More topical class swelling and pain relieving anti-inflammation drugs effect unobvious, the course for the treatment of is slow, controls table and does not make this, and the smell is awful, makes us being difficult to connect
By some drugs even will appear papule, blister using rear many people's local skins or feel the symptoms such as itch.Therefore it needs to grind
The anti-inflammatory analgetic ointment that send out a kind of completely new.
Invention content
The technical problems to be solved by the invention for the above-mentioned prior art the problem of, provide it is a kind of have it is apparent
The hemp floral leaf anti-inflammatory analgetic ointment and preparation method thereof of analgesic antiphlogistic, antibiotic effect.
The technical solution that the present invention solves above-mentioned technical problem is as follows：
A kind of hemp floral leaf anti-inflammatory analgetic ointment, in parts by weight, including the following raw material：Industrial hemp floral leaf extract 10
~60%, vaseline 20~40%, paraffin 10~35%, transdermal enhancer 5~18%, auxiliary material 0.1~5%.
Preferably, a kind of floral leaf anti-inflammatory analgetic ointment, in parts by weight, described includes the following raw material：Industrial hemp floral leaf
Extract 40%, vaseline 30%, paraffin 15%, transdermal enhancer 12%, auxiliary material 3%.
Preferably, cannabidiol content is 10% to 99% in the industrial hemp floral leaf extract；Wherein, the hemp
Floral leaf extract eliminates wherein drug ingredient tetrahydrocannabinol using special process, and main component is nontoxic cannabidiol
With a small amount of other terpene compounds and aliphatic acid etc., there is apparent analgesic, anti-inflammatory and antibacterial effect.Present invention industry simultaneously is big
What fried dough twist leaf extract raw material met that State Food and Drug Administration issues on June 30th, 2014 has used cosmetics former
Expect the requirement of catalogue notice (No. 11).
Preferably, the transdermal enhancer includes one kind or more in menthol, borneol, propylene glycol, azone, Chinese medical extract
Kind.
Preferably, the Chinese medical extract includes cinnamomum cassia extract, Flos Caryophylli extract, angelica extract, eucalyptus oil, intelligence development
A variety of mixtures in benevolence oil, the present invention selected by Chinese medical extract all have certain anti-inflammatory, analgesic efficacy, with the present invention
Main component industrial hemp floral leaf extract cooperates, and significantly improves anti-inflammatory, analgesic efficacy.
Preferably, the auxiliary material includes one or both of preservative, polyethylene glycol mixture.
Another mesh of the present invention, provides a kind of preparation method of hemp floral leaf anti-inflammatory analgetic ointment, specifically includes following step
Suddenly：
(1) paraffin and vaseline are put into 110~120 DEG C of heating in melt pot by weight makes raw material melt；
(2) it is put into mixing kettle after filtering melt paraffin and vaseline while hot, is cooled to 65~70 DEG C and keeps constant temperature,
Then industrial hemp floral leaf extract, transdermal enhancer, auxiliary material are added in mixing kettle by weight, it is stirring while adding, it is mixed
0.5~1 hour；
(3) sampling carries out the inspection of semifinished product, filling at product after qualified.
Preferably, mixing speed described in step (2) is 100~800rpm.
The application method of product of the present invention：It takes and is applied to affected part in right amount, daily 3~4 times, continuous use can fully recover from an illness for 3~5 days
More, if can be massaged a few minutes after smearing, drug absorption can be more effectively facilitated, to play a multiplier role.
The advantageous effect of the present invention compared with prior art：
1, it is safe and non-toxic, all natural work that anti-inflammatory analgetic ointment of the present invention, which uses completely new active constituent, main component,
Sparetime university's fried dough twist leaf extract has the bioactivity of analgesic, anti-inflammatory and antibacterial using cannabis leaf extract, in conjunction with other cooperations
Component, anti-inflammatory analgetic effect is apparent, also has certain anti-microbial property, and the pharmacological property ingredient in this product can be with rapid osmotic skin
The acute pains of injury such as the chronic aches such as skin, either arthralgia, or strain all have stronger analgesia, detumescence, anti-inflammatory work(
Effect.
2, product of the present invention not only has effects that anti-inflammatory analgetic, also has certain antibiotic effect, common compared with commercially available
The effect of antiphlogistic and analgesic ointment, is notable, and performance is stablized, and drug safety does not find any adverse reaction.
3, using simply, conveniently, significant effect has no toxic side effect product of the present invention.Since uptake is few, stomach will not be caused
The people of the adverse reactions such as enteron aisle, central nervous system, angiocarpy, especially allergic constitution, not will produce allergic problem.
4, anti-inflammatory analgetic ointment of the invention is easily fabricated, and preparation method technology degree is high, and cost is relatively low, is suitble to big rule
Mould produces.
Specific implementation mode
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
Embodiment 1
A kind of hemp floral leaf anti-inflammatory analgetic ointment, in parts by weight, including the following raw material：Industrial hemp floral leaf extract
10%, vaseline 40%, paraffin 35%, menthol 5%, cinnamomum cassia extract 5%, preservative 5%.
A kind of preparation method of hemp floral leaf anti-inflammatory analgetic ointment, specifically comprises the following steps：
(1) paraffin and vaseline are put into 110 DEG C of heating in melt pot by weight makes raw material melt；
(2) it is put into mixing kettle after filtering melt paraffin and vaseline while hot, is cooled to 65 DEG C and keeps constant temperature, then
Industrial hemp floral leaf extract, menthol, cinnamomum cassia extract, preservative are added in mixing kettle by weight, it is stirring while adding,
It is stirred 0.5 hour with the speed of 800rpm；
(3) sampling carries out the inspection of semifinished product, filling at product after qualified.
Embodiment 2
A kind of floral leaf anti-inflammatory analgetic ointment, in parts by weight, described includes the following raw material：Industrial hemp floral leaf extract
40%, vaseline 30%, paraffin 15%, borneol 6%, Flos Caryophylli extract 3%, angelica extract 3%, polyethylene glycol 3%.
A kind of preparation method of hemp floral leaf anti-inflammatory analgetic ointment, specifically comprises the following steps：
(1) paraffin and vaseline are put into 120 DEG C of heating in melt pot by weight makes raw material melt；
(2) it is put into mixing kettle after filtering melt paraffin and vaseline while hot, is cooled to 70 DEG C and keeps constant temperature, then
Industrial hemp floral leaf extract, borneol, Flos Caryophylli extract, angelica extract, polyethylene glycol are added in mixing kettle by weight,
It is stirring while adding, it is stirred 1 hour with the speed of 500rpm；
(3) sampling carries out the inspection of semifinished product, filling at product after qualified.
Embodiment 3
A kind of hemp floral leaf anti-inflammatory analgetic ointment, in parts by weight, including the following raw material：Industrial hemp floral leaf extract
60%, vaseline 20%, paraffin 10%, propylene glycol 6.6%, eucalyptus oil 3.3%, preservative 0.1%.
A kind of preparation method of hemp floral leaf anti-inflammatory analgetic ointment, specifically comprises the following steps：
(1) paraffin and vaseline are put into 110~120 DEG C of heating in melt pot by weight makes raw material melt；
(2) it is put into mixing kettle after filtering melt paraffin and vaseline while hot, is cooled to 65~70 DEG C and keeps constant temperature,
Then industrial hemp floral leaf extract, propylene glycol, eucalyptus oil, preservative are added in mixing kettle by weight, it is stirring while adding,
It is stirred 1 hour with the speed of 100rpm；
(3) sampling carries out the inspection of semifinished product, filling at product after qualified.
Embodiment 4
A kind of hemp floral leaf anti-inflammatory analgetic ointment, in parts by weight, including the following raw material：Industrial hemp floral leaf extract
30%, vaseline 30%, paraffin 20%, menthol 10%, Flos Caryophylli extract 4%, fructus alpiniae oxyphyllae oil 4%, preservative 2%.
A kind of preparation method of hemp floral leaf anti-inflammatory analgetic ointment, specifically comprises the following steps：
(1) paraffin and vaseline are put into 115 DEG C of heating in melt pot by weight makes raw material melt；
(2) it is put into mixing kettle after filtering melt paraffin and vaseline while hot, is cooled to 70 DEG C and keeps constant temperature, then
Industrial hemp floral leaf extract, azone, Flos Caryophylli extract, fructus alpiniae oxyphyllae oil, preservative are added in mixing kettle by weight, Bian Jia
Side is stirred, and is stirred 0.8 hour with the speed of 600rpm；
(3) sampling carries out the inspection of semifinished product, filling at product after qualified.
Embodiment 5
A kind of hemp floral leaf anti-inflammatory analgetic ointment, in parts by weight, including the following raw material：Industrial hemp floral leaf extract
50%, vaseline 20%, paraffin 24%, menthol 3%, propylene glycol 1%, eucalyptus oil 1%, preservative 1%.
A kind of preparation method of hemp floral leaf anti-inflammatory analgetic ointment, specifically comprises the following steps：
(1) paraffin and vaseline are put into 115 DEG C of heating in melt pot by weight makes raw material melt；
(2) it is put into mixing kettle after filtering melt paraffin and vaseline while hot, is cooled to 70 DEG C and keeps constant temperature, then
Industrial hemp floral leaf extract, menthol, propylene glycol, eucalyptus oil, preservative are added in mixing kettle by weight, side edged stirs
It mixes, is stirred 0.5 hour with the speed of 800rpm；
(3) sampling carries out the inspection of semifinished product, filling at product after qualified.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
Experiment
The patient of 50 traumatic injuries is chosen, swelling or extravasated blood symptom occurs in the affected part of these patients.By this 50 patients
It is randomly divided into two groups using table of random number method.Male 15 in control group 25, women 10 are age 15-60 Sui, average
28 years old age.In treatment group 25, male 10, women 15, age 17-56 Sui, average age 30 years old.
Diagnostic criteria is：
It cures：Pain disappears, and swelling recession or extravasated blood scatter, and affected part activity is freely.
It improves：Pain disappears substantially, and swelling is improved, and extravasated blood starts to scatter, and injury activity is dumb.
In vain：Pain, sign are without improvement after treatment.
Control group waist-leg is sprained or arthralgia patient gives the treatment of Western medicine anodyne；This is given for treatment
Invention ointment is treated.Observation 7 days, treatment results are as follows：
| It is effective | Effectively | In vain | |
| Treatment group's number | 24 | 1 | 0 |
| Contrast groups number | 8 | 16 | 1 |
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of hemp floral leaf anti-inflammatory analgetic ointment, which is characterized in that in parts by weight, including the following raw material：Industrial hemp is spent
Leaf extract 10~60%, vaseline 20~40%, paraffin 10~35%, transdermal enhancer 5~18%, auxiliary material 0.1~5%.
2. hemp floral leaf anti-inflammatory analgetic ointment according to claim 1, which is characterized in that in parts by weight, including it is as follows
Raw material：Industrial hemp floral leaf extract 40%, vaseline 30%, paraffin 15%, transdermal enhancer 12%, auxiliary material 3%.
3. hemp floral leaf anti-inflammatory analgetic ointment according to claim 1 or 2, which is characterized in that the industrial hemp floral leaf
Cannabidiol content is 10% to 99% in extract.
4. hemp floral leaf anti-inflammatory analgetic ointment according to claim 1 or 2, which is characterized in that the transdermal enhancer includes thin
It is one or more in lotus brain, borneol, propylene glycol, azone, Chinese medical extract.
5. hemp floral leaf anti-inflammatory analgetic ointment according to claim 4, which is characterized in that the Chinese medical extract includes meat
A variety of mixtures in osmanthus extract, Flos Caryophylli extract, angelica extract, eucalyptus oil, fructus alpiniae oxyphyllae oil.
6. hemp floral leaf anti-inflammatory analgetic ointment according to claim 1 or 2, which is characterized in that the auxiliary material includes anti-corrosion
Mixture is planted in one or both of agent, polyethylene glycol.
7. a kind of preparation method of hemp floral leaf anti-inflammatory analgetic ointment as claimed in claim 1 or 2, which is characterized in that specific packet
Include following steps：
(1) paraffin and vaseline are put into 110~120 DEG C of heating in melt pot by weight makes raw material melt；
(2) it is put into mixing kettle after filtering melt paraffin and vaseline while hot, is cooled to 65~70 DEG C and keeps constant temperature, then
Industrial hemp floral leaf extract, transdermal enhancer, auxiliary material are added in mixing kettle by weight, it is stirring while adding, mixing 0.5~
1 hour；
(3) sampling carries out the inspection of semifinished product, filling at product after qualified.
8. the preparation method of hemp floral leaf anti-inflammatory analgetic ointment according to claim 7, which is characterized in that in step (2)
The mixing speed is 100~800rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810416392.8A CN108379347A (en) | 2018-05-03 | 2018-05-03 | A kind of hemp floral leaf anti-inflammatory analgetic ointment and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810416392.8A CN108379347A (en) | 2018-05-03 | 2018-05-03 | A kind of hemp floral leaf anti-inflammatory analgetic ointment and preparation method thereof |
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| CN108379347A true CN108379347A (en) | 2018-08-10 |
Family
ID=63064856
Family Applications (1)
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|---|---|---|---|
| CN201810416392.8A Pending CN108379347A (en) | 2018-05-03 | 2018-05-03 | A kind of hemp floral leaf anti-inflammatory analgetic ointment and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110354069A (en) * | 2019-07-02 | 2019-10-22 | 广州艾蓓生物科技有限公司 | A kind of ointment and preparation method thereof |
| CN112274563A (en) * | 2020-11-11 | 2021-01-29 | 云南汉木森生物科技有限责任公司 | Cannabis leaf quick-acting pain-relieving and soothing paste and preparation method thereof |
| CN113116865A (en) * | 2021-04-30 | 2021-07-16 | 中山威习日化科技有限公司 | Spray and preparation method thereof |
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| US20120264818A1 (en) * | 2011-04-15 | 2012-10-18 | Jon Newland | Topical Compositions with Cannabis Extracts |
| CN106265364A (en) * | 2016-09-30 | 2017-01-04 | 汉义生物科技（北京）有限公司 | A kind of compositions containing Fructus Cannabis extract and the application in cleaning supplies thereof |
| CN106278828A (en) * | 2016-08-16 | 2017-01-04 | 云南汉素生物科技有限公司 | A kind of method extracting cannabidiol from industrial hemp floral leaf |
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2018
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| CN1480130A (en) * | 2003-07-22 | 2004-03-10 | 复旦大学 | Ointment for eliminating wind-damp, antiinflammation and ease pain as well as its preparing method |
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| CN106278828A (en) * | 2016-08-16 | 2017-01-04 | 云南汉素生物科技有限公司 | A kind of method extracting cannabidiol from industrial hemp floral leaf |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110354069A (en) * | 2019-07-02 | 2019-10-22 | 广州艾蓓生物科技有限公司 | A kind of ointment and preparation method thereof |
| CN112274563A (en) * | 2020-11-11 | 2021-01-29 | 云南汉木森生物科技有限责任公司 | Cannabis leaf quick-acting pain-relieving and soothing paste and preparation method thereof |
| CN113116865A (en) * | 2021-04-30 | 2021-07-16 | 中山威习日化科技有限公司 | Spray and preparation method thereof |
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Application publication date: 20180810 |
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