CN110354069A - A kind of ointment and preparation method thereof - Google Patents

A kind of ointment and preparation method thereof Download PDF

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Publication number
CN110354069A
CN110354069A CN201910596901.4A CN201910596901A CN110354069A CN 110354069 A CN110354069 A CN 110354069A CN 201910596901 A CN201910596901 A CN 201910596901A CN 110354069 A CN110354069 A CN 110354069A
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ointment
oil
accounts
weight
vaseline
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CN110354069B (en
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沈进
邓伟健
林锦雄
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Guangzhou I & B Biological Technology Co Ltd
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Guangzhou I & B Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
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  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides a kind of ointment and preparation method thereof.Ointment of the present invention includes gelling agent and emollients, gelling agent includes the vaseline of the hydroxy stearic acid and 5-60% that account for ointment weight 0.3-2% respectively, emollients include the caprylic/capric triglyceride for accounting for ointment weight 0.01-20%, it is rationally compounded by hydroxy stearic acid, vaseline and caprylic/capric triglyceride, ointment of the present invention is in gel gel, soft-touch, with excellent cold-resistant, heat-resistant stability；Prevent mosquito from biting with stronger by adding menthol, blue gum leaf oil, camphor, safflower seed oil and the caryophyllus oil of reasonable compatibility again, clearing away heat and eliminating dampeness, dredging collateral dredging, treatment redness, slight the effect of spraining, also there is natural flavor and good bacteriostasis simultaneously, without adding essence and preservative, naturally there is safety, furthermore, ointment preparation process of the present invention is simple, is easy to technology production.

Description

A kind of ointment and preparation method thereof
Technical field
The present invention relates to ointment arts, and in particular to a kind of ointment and preparation method thereof.
Background technique
There are the following problems for presently commercially available ointment product:
(1) formula contains menthol, vaseline and/paraffin more, and thermal stability is bad, and temperature is more than 40 DEG C of easy condensate oils, leads The effect of causing functional component is weakened；
(2) ointment effect is single mostly, do not have prevent mosquito from biting, be red and swollen, slight strain, detoxicating, relieving inflammation, heat-clearing The multiple efficacies such as wet, dredging collateral dredging.
Therefore, it is necessary to develop a stabilization, multi-functional ointment.
Summary of the invention
It is an object of the invention to overcome drawbacks described above in the prior art, a kind of ointment and preparation method thereof is provided.
To achieve the above object, the technical solution adopted by the present invention are as follows:
In a first aspect, it includes gelling agent and emollients, the gelling agent includes difference the present invention provides a kind of ointment The hydroxy stearic acid of the ointment weight 0.3-2% and the vaseline of 5-60% are accounted for, the emollients include to account for the ointment weight The caprylic/capric triglyceride of 0.01-20%.It has been found that hydroxy stearic acid, vaseline and caprylic/capric triglyceride are multiple With that can form gel gel, soft-touch is easy to apply, when ointment include account for hydroxy stearic acid that its weight is respectively 0.3-2%, When the caprylic/capric triglyceride of the vaseline of 5-60% and 0.01-20%, be formed by gel gel have well it is cold-resistant, Heat-resistant stability can effectively prevent both effectiveness ingredient contained in formula and be precipitated under high temperature, low temperature environment, to ensure that function The effect of effect property ingredient.
Preferably, it being calculated on the basis of the total weight of the ointment, hydroxy stearic acid accounts for 0.6%, and vaseline accounts for 33.35%, Caprylic/capric triglyceride accounts for 6%.With this condition, the cold-resistant of the ointment, heat-resistant stability are more preferable.
Preferably, the ointment also includes functional component, and the functional component includes to account for the ointment weight 1- respectively 40% menthol, blue gum leaf oil, camphor, safflower seed oil and caryophyllus oil；It is further preferred that being with the total weight of the ointment Benchmark, menthol account for 15%, and blue gum leaf oil accounts for 5%, and camphor accounts for 10%, and safflower seed oil accounts for 10%, and caryophyllus oil accounts for 5%.It is thin Lotus brain is a kind of cyclic alcohol of saturation obtained in the peppermint oil, has effects that dispelling wind, heat-clearing and removing toxic substances；Blue gum leaf oil has Improve respiratory tract function, anti parasitic, promote the effects of skin absorption, wind-expelling pain-stopping, antipruritic, relieving summer-heat, treatment burn；Camphor tool There is the effect of antipruritic orifice opening, desinsection, swelling and pain relieving；Safflower seed oil is a kind of carminative, can be used to treat treating rheumatic ostealgia, bruise It sprains, pruitus；Caryophyllus oil has the effect of analgesic；The ointment contains menthol, blue gum leaf oil, camphor, safflower seed oil With caryophyllus oil with preventing mosquito from biting, clearing away heat and eliminating dampeness, dredging collateral dredging treat red and swollen, slight strain and other effects, and peppermint Brain, blue gum leaf oil, camphor and safflower seed oil all have natural flavor, are not required to add other essence again, do not have to addition especially and close At essence；It is calculated when on the basis of the total weight of the ointment, menthol, blue gum leaf oil, camphor, safflower seed oil and cloves oil When not accounting for 1-40%, when the ointment compares because of the synergistic effect between this five kinds of ingredients containing only one of this five kinds of ingredients, With more preferable effect, especially being calculated when on the basis of the total weight of the ointment, menthol accounts for 15%, and blue gum leaf oil accounts for 5%, Camphor accounts for 10%, and safflower seed oil accounts for 10%, when caryophyllus oil accounts for 5%, and effect is more preferable.In addition, blue gum leaf oil has fungistatic effect, energy Preservative efficacy is played instead of preservative.
Preferably, the gelling agent also includes the mixture of the microwax and paraffin that account for the ointment weight 1-20% respectively And the beeswax of 0.1-20%, wherein the weight ratio of microwax and paraffin is 3:7；It is further preferred that the gelling agent is also wrapped Mixture containing the microwax and paraffin for accounting for the ointment weight 14% and 1% beeswax.By addition microwax, paraffin and Beeswax keeps ointment easy to form, uses convenient for picking, while also making ointment use feeling and stability more preferable.
Preferably, the ointment also includes oil-soluble colorant, and the oil-soluble colorant accounts for the ointment weight 0.002-2%；It is further preferred that the oil-soluble colorant accounts for the ointment weight 0.02%；It is further preferred that institute Stating oil-soluble colorant is chrome oxide green, as CI 77288.
Second aspect, the present invention provides a kind of preparation methods of ointment comprising following steps:
(1) by vaseline, microwax, paraffin, hydroxy stearic acid, beeswax, caprylic/capric triglyceride and oil-soluble colorant Mixing, is heated to 90-95 DEG C, waits stirrings to after being completely dissolved uniformly, is cooled to 60-80 DEG C, heat preservation for standby use obtains A phase materials；
(2) B phase materials are sequentially added in the A phase materials, is kept the temperature at 60-80 DEG C, stirred to being completely dissolved, defoam, The filling ointment to obtain the final product.
Preferably, the oil-soluble colorant is chrome oxide green, as CI 77288.
Compared with prior art, the present invention has the following advantages and beneficial effects:
(1) ointment soft-touch of the present invention, it is easy to apply, with excellent cold-resistant, heat-resistant stability, it can effectively prevent formula Contained in both effectiveness ingredient be precipitated under high temperature, low temperature environment, to ensure that the effect of both effectiveness ingredient.
(2) ointment of the present invention has and rationally compounding menthol, blue gum leaf oil, camphor, safflower seed oil and caryophyllus oil Preferably prevent mosquito from biting, clearing away heat and eliminating dampeness, dredging collateral dredging, treatment redness, slight strain and other effects, while also there is natural perfume Taste and good bacteriostasis are not required to additionally add essence and preservative, natural and safety.
(3) the preparation method simple process of ointment of the present invention, condition is controllable, easy to industrialized production.
Detailed description of the invention
Fig. 1 is the photo of the ointment in embodiment 2.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention It is described further.
Embodiment 1-9
Embodiment 1-9 is a kind of embodiment of ointment of the present invention, and the composition of these compositions is as shown in table 1, wherein micro- The mixture of brilliant wax and paraffin is made of the microwax that weight ratio is 3:7 and paraffin.
Composition/% of ointment in 1 embodiment 1-9 of table
Ointment in embodiment 1-9 is prepared by following steps:
(1) by vaseline, microwax, paraffin, hydroxy stearic acid, beeswax, caprylic/capric triglyceride and oil-soluble colorant Mixing, is heated to 90-95 DEG C, waits stirrings to after being completely dissolved uniformly, is cooled to 60-80 DEG C, heat preservation for standby use obtains A phase materials；
(2) B phase materials are sequentially added in the A phase materials, is kept the temperature at 60-80 DEG C, stirred to being completely dissolved, defoam, The filling ointment to obtain the final product；
Wherein, B phase materials include menthol, blue gum leaf oil, camphor, safflower seed oil and caryophyllus oil.
Comparative example 1
Comparative example 1 is a kind of ointment, except without in addition to microwax, paraffin and beeswax, other compositions and ratio with implementation Example 2 is identical.
Comparative example 2
Comparative example 2 is a kind of ointment, except without in addition to hydroxy stearic acid ester, other compositions and ratio with 2 phase of embodiment Together.
Comparative example 3
Comparative example 3 is a kind of ointment, and in addition to without menthol, other compositions and ratio are same as Example 2.
Comparative example 4
Comparative example 4 is a kind of ointment, and in addition to without blue gum leaf oil, other compositions and ratio are same as Example 2.
Comparative example 5
Comparative example 5 is a kind of ointment, and in addition to without camphor, other compositions and ratio are same as Example 2.
Comparative example 6
Comparative example 6 is a kind of ointment, and in addition to without safflower seed oil, other compositions and ratio are same as Example 2.
Comparative example 7
Comparative example 7 is a kind of ointment, and in addition to without caryophyllus oil, other compositions and ratio are same as Example 2.
Applicant uses following experimental study effect of the invention, specific as follows:
(1) stability test
Test object: the ointment in embodiment 1-9 and comparative example 1-2.
Test method: test sample is respectively placed in 50 DEG C, 3 months at room temperature and -20 DEG C, whether steady observes sample later It is fixed, and test sample hardness.
Test result: 2 are specifically shown in Table.
The stability and hardness test result of 2 sample of table
Test sample 50℃ Room temperature -20℃
Embodiment 1 Stablize, it is partially soft Stablize, hardness is moderate Stablize
Embodiment 2 Stablize, hardness is moderate Stablize, hardness is moderate Stablize
Embodiment 3 Stablize, hardness is moderate Stablize, hardness is moderate There is crackle on surface
Embodiment 4 It is unstable, it is slight fuel-displaced Stablize, hardness is moderate Stablize
Embodiment 5 Stablize Stablize, partially firmly Stablize
Embodiment 6 Stablize Stablize, partially firmly Stablize
Embodiment 7 Stablize Stablize, partially firmly Stablize
Embodiment 8 Stablize Stablize, partially firmly Stablize
Embodiment 9 Stablize Stablize, partially firmly Stablize
Comparative example 1 It is unstable, hence it is evident that fuel-displaced Stablize, it is partially soft Stablize
Comparative example 2 Fuel-displaced thawing occurs Stablize Stablize
Although the ointment room temperature stability inferior in comparative example 1 is good, lotion is softer, uneven surface, and appearance is not It is good-looking, it is also not susceptible to pick use.
(2) efficacy test
Test object: the ointment in embodiment 2 and comparative example 3-7.
Test method: test sample is distributed to 30 subjects, the mosquito-proof effect of investigation statistics sample, dredging collateral are clear later It becomes silted up, the effect of analgesic.
Test result: it investigates and shows to compare embodiment 2, the effect is relatively poor for comparative example 3 and the mosquito-proof sting of comparative example 5, i.e., Lack menthol or camphor, mosquito-proof sting declines；Embodiment 2 is compared, the dredging collateral dredging effect of comparative example 4 and 6 is poor, Lack blue gum leaf oil or safflower oil, dredging collateral dredging declines；Embodiment 2 is compared, 5 analgesic effect of comparative example is poor, i.e., Lack caryophyllus oil, analgesic effect weakens.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention And range.

Claims (10)

1. a kind of ointment, it is characterised in that: the ointment includes gelling agent and emollients, and the gelling agent is described comprising accounting for respectively The hydroxy stearic acid of ointment weight 0.3-2% and the vaseline of 5-60%, the emollients include to account for the ointment weight 0.01- 20% caprylic/capric triglyceride.
2. ointment according to claim 1, it is characterised in that: calculated on the basis of the total weight of the ointment, hydroxyl is hard Resin acid accounts for 0.6%, and vaseline accounts for 33.35%, and caprylic/capric triglyceride accounts for 6%.
3. ointment according to claim 1, it is characterised in that: the ointment also includes functional component, the functional component Menthol, blue gum leaf oil, camphor, safflower seed oil and caryophyllus oil comprising accounting for the ointment weight 1-40% respectively.
4. ointment according to claim 3, it is characterised in that: calculated on the basis of the total weight of the ointment, menthol 15% is accounted for, blue gum leaf oil accounts for 5%, and camphor accounts for 10%, and safflower seed oil accounts for 10%, and caryophyllus oil accounts for 5%.
5. ointment according to claim 1, it is characterised in that: the gelling agent also includes to account for the ointment weight 1- respectively The beeswax of 20% microwax and the mixture of paraffin and 0.1-20%, wherein the weight ratio of microwax and paraffin is 3:7.
6. ointment according to claim 5, it is characterised in that: calculated on the basis of the total weight of the ointment, microwax 14% is accounted for the mixture of paraffin, beeswax accounts for 1%.
7. ointment according to claim 1, it is characterised in that: the ointment also includes oil-soluble colorant, and the oil is molten Property colorant accounts for the 0.002-2% of the ointment weight.
8. ointment according to claim 7, it is characterised in that: the oil-soluble colorant accounts for the ointment weight 0.02%.
9. ointment according to claim 8, it is characterised in that: the oil-soluble colorant is chrome oxide green.
10. a kind of preparation method of ointment, it is characterised in that: the preparation method includes the following steps:
(1) vaseline, microwax, paraffin, hydroxy stearic acid, beeswax, caprylic/capric triglyceride and oil-soluble colorant are mixed It closes, is heated to 90-95 DEG C, wait stirrings to after being completely dissolved uniformly, be cooled to 60-80 DEG C, heat preservation for standby use obtains A phase materials；
(2) B phase materials are sequentially added in the A phase materials, heat preservation is being cooled to 60-80 DEG C, stirs to being completely dissolved, disappears Bubble, the filling ointment to obtain the final product；
Wherein, B phase materials include menthol, blue gum leaf oil, camphor, safflower seed oil and caryophyllus oil.
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Publication number Priority date Publication date Assignee Title
CN112353931A (en) * 2020-11-25 2021-02-12 广州旭升化工科技有限公司 Chinese herbal medicine compound ointment for soothing skin of infants and preparation method thereof

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