CN112353931A - Chinese herbal medicine compound ointment for soothing skin of infants and preparation method thereof - Google Patents

Chinese herbal medicine compound ointment for soothing skin of infants and preparation method thereof Download PDF

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Publication number
CN112353931A
CN112353931A CN202011342879.XA CN202011342879A CN112353931A CN 112353931 A CN112353931 A CN 112353931A CN 202011342879 A CN202011342879 A CN 202011342879A CN 112353931 A CN112353931 A CN 112353931A
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extract
skin
radix
herbal medicine
chinese herbal
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薛旭升
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Guangzhou Cxs Chemical Science Technology Co ltd
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
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    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

The invention discloses a Chinese herbal medicine compound ointment for soothing skin of infants and a preparation method thereof, and the Chinese herbal medicine compound ointment comprises the following components in percentage by weight: 1-10% of microcrystalline wax, 4-25% of beeswax, 5-45% of low erucic acid rapeseed oil, 5-30% of lecithin, 3-20% of cocoa butter, 0.1-5% of tocopherol, 0.1-5% of bisabolol, 0-15% of caprylic/capric triglyceride, 0-40% of sunflower seed oil, 0.1-8% of lavender essential oil, 0-5% of sanshan wasabi essence, 0.1-5% of radix lithospermi extract, 0.1-5% of angelica root extract, 0.1-5% of radix sileris extract, 0.1-5% of radix rehmanniae extract and 0.1-5% of ginger root extract; the Chinese herbal medicine compound ointment for soothing the skin of the infant can effectively solve the skin problems of eczema, redness and swelling, pruritus and the like of a baby diaper, and soothes the young skin of the baby. The safety and the effectiveness are realized, and the long-term multiple use can be realized; the ointment has the advantages of reasonable formula matching, upgraded use feeling, bright and fine appearance, special fragrance, easy lifting, easy uniform smearing on the skin, good compatibility with the skin, easy absorption and no greasiness.

Description

Chinese herbal medicine compound ointment for soothing skin of infants and preparation method thereof
Technical Field
The invention relates to the technical field of ointments, and particularly relates to a Chinese herbal medicine compound ointment for soothing skin of infants and a preparation method thereof.
Background
The use of paper diapers by newborn babies has become widespread. But also tend to cause skin problems for infants as diapers are used. The skin of the baby is delicate and sensitive, but the baby is weak and small and has no independent consciousness, so that the skin problems of eczema, red swelling, pruritus and the like can easily occur when the baby frequently urinates the trousers.
The ointment for soothing the skin of the baby in the market is partially a medicine or contains hormone and cannot be used for multiple times for a long time, and the partial soothing ointment is a cosmetic, but is prepared by only using a single lithospermum component and solid wax, so that the effect is slight, and the skin feeling is poor.
Disclosure of Invention
The invention aims to provide the Chinese herbal medicine compound ointment for soothing the skin of the infant, which can effectively solve the skin problems of eczema, redness and swelling, pruritus and the like of the baby diaper and soothe the young skin of the baby. The safety and the effectiveness are realized, and the long-term multiple use can be realized; the ointment has the advantages of bright and fine appearance, special fragrance, easy lifting, easy uniform smearing on the skin, good compatibility with the skin, easy absorption and no greasiness.
The technical problem to be solved by the invention is realized by the following technical scheme:
a Chinese herbal medicine compound ointment for soothing the skin of infants comprises the following components in percentage by weight: 1-10% of microcrystalline wax, 4-25% of beeswax, 5-45% of low erucic acid rapeseed oil, 5-30% of lecithin, 3-20% of cocoa butter, 0.1-5% of tocopherol, 0.1-5% of bisabolol, 0-15% of caprylic/capric triglyceride, 0-40% of sunflower seed oil, 0.1-8% of lavender essential oil, 0-5% of sanshan wasabi essence, 0.1-5% of radix lithospermi extract, 0.1-5% of angelica root extract, 0.1-5% of radix sileris extract, 0.1-5% of radix rehmanniae extract and 0.1-5% of ginger root extract.
A preparation method of the Chinese herbal medicine compound ointment for soothing the skin of the infant comprises the following steps:
(1) adding microcrystalline wax, beeswax, low erucic acid rapeseed oil, lecithin, cocoa butter, caprylic/capric triglyceride, sunflower seed oil and Sanbehen essence into an oil phase pot, heating to 75-80 deg.C for complete dissolution, and stirring;
(2) mixing tocopherol, bisabolol, lavender essential oil, radix Arnebiae extract, radix Angelicae sinensis extract, radix Saposhnikoviae extract, and radix rehmanniae extract, and stirring;
(3) and (3) cooling the temperature in the step (1) to 73 ℃, putting the raw materials in the step (2) into the step (1), uniformly stirring and cooling.
Has the advantages that: the skin care product is natural in raw materials, is specially added with Chinese herbal medicine components, is compatible according to the traditional Chinese medicine principle, can effectively solve the skin problems of eczema, redness and swelling, pruritus and the like of the baby diaper, and can relieve the young skin of the baby. The safety and the effectiveness are realized, and the long-term multiple use can be realized; the ointment has the advantages of bright and fine appearance, special fragrance, easiness in picking up, easiness in uniform smearing on skin, good affinity with skin, easiness in absorption and no greasiness, fills the gap of a soothing product integrating efficacy and use feeling in the market, and provides a powerful guarantee for skin health of infants.
The special liquid oil prepared by the low erucic acid rapeseed oil through the optimal refining process is a food-grade oil product, and the oil is rich in natural vitamin E and GLA nutrient elements and has a good nourishing effect on skin;
the lecithin is beneficial to repairing and improving the skin barrier function, so that the skin moisturizing performance is improved, the skin is smooth, and the skin care product is particularly suitable for delicate skin of infants;
the cocoa seed butter is extracted from cocoa seeds and is prepared by squeezing and refining, is a natural vegetable oil, is rich in natural phytosterol, effectively moistens the skin, and has the functions of efficiently moisturizing and softening the skin;
the tocopherol is a vitamin with natural source, has good antioxidant effect, and can stabilize the product without rancidity and flavor change;
the bisabolol has the effects of protecting and nursing the inflammation damaged skin of the baby due to the diaper and the like, has good anti-inflammatory effect and certain bacteriostatic activity;
the lavender essential oil is extracted from lavender, and can clean skin, promote regeneration and recovery of damaged tissues and other skin care functions;
the alkanna tinctoria root extract has the effects of resisting inflammation, sterilizing, relieving pain, promoting wound healing and the like, and has a good effect on the damaged skin of the baby diaper;
the angelica root extract has the functions of promoting blood circulation and relieving itching;
the radix sileris extract has the functions of relieving fever, easing pain, resisting bacteria and diminishing inflammation, can resist bacteria and has certain inhibiting effect on swelling and inflammation;
the rehmannia root extract has the functions of clearing away heat and toxic materials;
the ginger root extract has the functions of moisturizing and bacteriostasis.
Detailed Description
The present invention will be described in further detail with reference to specific examples, but the present invention is not limited to these examples in any way.
Example 1
The components were weighed out separately according to the formulation shown in table 1 below.
TABLE 1
Composition (I) Proportioning
Microcrystalline wax 7%
Beeswax (Cera flava) 15%
Low erucic acid rapeseed oil 11.5%
Lecithin 30%
Cocoa seed butter 6%
Tocopherol 2%
Bisabolol 1%
Caprylic capric acid triglyceride 6%
Sunflower seed oil 5%
Lavender essential oil 7%
Sanshan wasabin essence 1%
Angelica root extract 2%
Ledebouriella root extract 1%
Rehmannia root extract 1%
Ginger root extract 0.5%
Radix Arnebiae extract 4%
(1) Adding microcrystalline wax, beeswax, low erucic acid rapeseed oil, lecithin, cocoa butter, caprylic/capric triglyceride, sunflower seed oil and Sanbehen essence into an oil phase pot, heating to 75-80 deg.C for complete dissolution, and stirring;
(2) mixing tocopherol, bisabolol, lavender essential oil, radix Arnebiae extract, radix Angelicae sinensis extract, radix Saposhnikoviae extract, and radix rehmanniae extract, and stirring;
(3) and (3) cooling the temperature in the step (1) to 73 ℃, putting the raw materials in the step (2) into the step (1), uniformly stirring and cooling.
And (3) effect testing:
double-blind, randomized, control study testing was selected: subjects (n ═ 20) used the ointment of application example 1 and a common ointment product a selected in the supermarket as a placebo, applied no more than 5 times a day for each diaper change, for four weeks, volunteers evenly healthy babies aged 0-3 years, the ointment of example 1 applied in the left hip area and the ointment product a applied in the right hip area.
The diaper is changed after the baby urinates for 4 hours every time, and the record is observed every day.
Wherein: the test results were scored at a full score of 5 points, preferably no red spots, a red wind of 5 points, and worst skin appearance problems of 0 points, as shown in table 2 below.
TABLE 2
Figure BDA0002799007590000051
Figure BDA0002799007590000061
As can be seen from the table 2, the ointment provided by the invention can effectively solve the skin problems of eczema, redness and swelling, pruritus and the like of the baby diaper, can relieve the young and tender skin of the baby, is safe and effective, can be used repeatedly for a long time, and has a more excellent effect.
The above-mentioned embodiments only express the embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (2)

1. A Chinese herbal medicine compound ointment for soothing the skin of an infant is characterized by comprising the following components in percentage by weight: 1-10% of microcrystalline wax, 4-25% of beeswax, 5-45% of low erucic acid rapeseed oil, 5-30% of lecithin, 3-20% of cocoa butter, 0.1-5% of tocopherol, 0.1-5% of bisabolol, 0-15% of caprylic/capric triglyceride, 0-40% of sunflower seed oil, 0.1-8% of lavender essential oil, 0-5% of sanshan wasabi essence, 0.1-5% of radix lithospermi extract, 0.1-5% of angelica root extract, 0.1-5% of radix sileris extract, 0.1-5% of radix rehmanniae extract and 0.1-5% of ginger root extract.
2. A method for preparing the Chinese herbal medicine compound ointment for soothing the skin of the infant as claimed in claim 1, which comprises the following steps:
(1) adding microcrystalline wax, beeswax, low erucic acid rapeseed oil, lecithin, cocoa butter, caprylic/capric triglyceride, sunflower seed oil and Sanbehen essence into an oil phase pot, heating to 75-80 deg.C for complete dissolution, and stirring;
(2) mixing tocopherol, bisabolol, lavender essential oil, radix Arnebiae extract, radix Angelicae sinensis extract, radix Saposhnikoviae extract, and radix rehmanniae extract, and stirring;
(3) and (3) cooling the temperature in the step (1) to 73 ℃, putting the raw materials in the step (2) into the step (1), uniformly stirring and cooling.
CN202011342879.XA 2020-11-25 2020-11-25 Chinese herbal medicine compound ointment for soothing skin of infants and preparation method thereof Pending CN112353931A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113143804A (en) * 2021-04-28 2021-07-23 广州亦妆生物科技有限公司 Plant composition and application thereof
CN115531229A (en) * 2022-11-08 2022-12-30 浙江海心智惠科技有限公司 Preparation method of skin-moistening plant essential oil
CN116327620A (en) * 2023-04-12 2023-06-27 广州芭妍化妆品有限公司 Calendula skin care oil for infants and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1110158A (en) * 1994-04-15 1995-10-18 彭勃 Zizhi medical cream
CN110236988A (en) * 2019-07-08 2019-09-17 广州市中通生化制品有限公司 A kind of antiallergic is releived multiple remediation composition and its ointment and preparation method
CN110327438A (en) * 2019-07-19 2019-10-15 广州艾蓓生物科技有限公司 One kind is releived massage cream
CN110354069A (en) * 2019-07-02 2019-10-22 广州艾蓓生物科技有限公司 A kind of ointment and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1110158A (en) * 1994-04-15 1995-10-18 彭勃 Zizhi medical cream
CN110354069A (en) * 2019-07-02 2019-10-22 广州艾蓓生物科技有限公司 A kind of ointment and preparation method thereof
CN110236988A (en) * 2019-07-08 2019-09-17 广州市中通生化制品有限公司 A kind of antiallergic is releived multiple remediation composition and its ointment and preparation method
CN110327438A (en) * 2019-07-19 2019-10-15 广州艾蓓生物科技有限公司 One kind is releived massage cream

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113143804A (en) * 2021-04-28 2021-07-23 广州亦妆生物科技有限公司 Plant composition and application thereof
CN115531229A (en) * 2022-11-08 2022-12-30 浙江海心智惠科技有限公司 Preparation method of skin-moistening plant essential oil
CN116327620A (en) * 2023-04-12 2023-06-27 广州芭妍化妆品有限公司 Calendula skin care oil for infants and preparation method thereof
CN116327620B (en) * 2023-04-12 2023-11-07 广州芭妍化妆品有限公司 Calendula skin care oil for infants and preparation method thereof

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Application publication date: 20210212