CN110755323A

CN110755323A - Lithospermum erythrorhizon nursing cream and preparation method thereof

Info

Publication number: CN110755323A
Application number: CN201911169235.2A
Authority: CN
Inventors: 徐华; 赵焱; 赵艳红
Original assignee: SUZHOU DONGFANGZHIBAO COSMETIC CO Ltd
Current assignee: SUZHOU DONGFANGZHIBAO COSMETIC CO Ltd
Priority date: 2019-11-26
Filing date: 2019-11-26
Publication date: 2020-02-07
Anticipated expiration: 2039-11-26
Also published as: CN110755323B

Abstract

The invention discloses a lithospermum nursing cream and a preparation method thereof, and belongs to the field of daily chemicals. The lithospermum nursing cream mainly comprises caprylic/capric triglyceride, alkanna tinctoria root, dimethiconol, white beeswax, hydrogenated castor oil, glyceryl behenate, triglyceride C10-18 fatty acid, rapeseed oil, glyceryl stearate, phytosterol oleate, menthol and the like. In the preparation method, the arnebia root is used for extracting the arnebia oil, and is refined by a special process together with vegetable oil such as olive oil, rapeseed oil and the like, so that the extraction and the stability of active ingredients of the arnebia are ensured to the maximum extent. The prepared lithospermum nursing cream not only has the effects of sterilization and disinfection, but also can solve the skin problems of dryness, pruritus, rhagadia, redness and swelling and the like, and is mild and non-irritating to skin.

Description

Lithospermum erythrorhizon nursing cream and preparation method thereof

Technical Field

The invention belongs to the field of daily chemicals, and particularly relates to a lithospermum nursing paste and a preparation method thereof.

Background

Radix Arnebiae is a Chinese medicinal material with sweet and cold nature and taste, has effects of promoting blood circulation for removing blood stasis, removing toxic substance, promoting eruption and cooling blood, and can be used for treating eczema, scald due to hot water and fire, and blood heat and toxic materials. Radix Arnebiae is often combined with Chinese medicinal materials such as radix Angelicae sinensis, radix Angelicae Dahuricae, and Borneolum Syntheticum to regulate immunity, promote blood circulation, enrich blood, clear away heat and toxic materials, relieve swelling and pain, and inhibit bacteria.

At present, the chemical components, pharmacological action and extraction process in the lithospermum are researched comprehensively and deeply in China, wherein the main components of the lithospermum are various naphthoquinone compounds such as shikonin, isobutyryl shikonin, acetylshikonin and the like, the wide pharmacological action is realized, in addition, the naphthoquinone compounds are extremely unstable, the temperature influence is large, and the stability of the naphthoquinone compounds can be damaged by high temperature. Therefore, an efficient method for extracting alkannin is of great importance.

The Chinese pharmacopoeia describes that the quality of three types of lithospermum is the best, namely Sinkiang lithospermum (soft lithospermum), lithospermum and lithospermum root. The lithospermum has the effects of resisting inflammation, inhibiting bacteria and the like, has obvious inhibiting effect on staphylococcus aureus, pseudomonas aeruginosa and the like, can promote the growth of cells on the surface of skin and accelerate wound healing, has stronger antioxidant activity, and can effectively remove free radicals.

CN109481725A discloses a ready-to-use compound lithospermum oil dressing and a preparation method thereof. The preparation method comprises the steps of mixing and sealing the lithospermum, the polygonum cuspidatum, the borneol, the vitamin E oil, the inositol hexaphosphate and the olive oil, then placing the sealed container in a vacuum constant temperature box, turning the sealed container every other hour to ensure that the medicines are fully and uniformly mixed, then cooling the sealed container to room temperature, filtering to remove impurities, adding the vitamin E oil and the inositol hexaphosphate to be uniformly mixed, filtering and sterilizing to obtain medicine leaching oil, soaking the medicine leaching oil into a single-layer polyester fiber net under the aseptic condition, and placing the medicine leaching oil into a sterile aluminum foil bag. Animal experiment research and clinical experiment research are respectively carried out, and experimental test results show that the shikonin oil gauze can obviously improve the healing speed of burn wounds, and can reduce the incidence rate and the generation area of scars aiming at healing wounds with scars of II-III degrees, but the preparation method has complex process and strict environmental requirements.

CN109432337A discloses a arnebia oil with skin care, traumatic injury stopping effects and its preparation method, wherein arnebia oil comprises arnebia, saffron, buffalo horn, frankincense, angelica, glabrous greenbrier rhizome, dahurian angelica root, cicada slough, myrrh, borneol, dendrobium, cortex lycii radicis, hispid fig and vegetable oil. The preparation method comprises soaking Olibanum, radix Angelicae sinensis, rhizoma Smilacis Glabrae, radix Angelicae Dahuricae, periostracum Cicadae and Myrrha in Chinese liquor, taking out the residues, adding into boiling vegetable oil A to obtain medicinal oil A, adding radix Arnebiae, stigma croci Sativi and cornu Bubali into the medicinal oil A, decocting for 6-10h, cooling, adding Borneolum Syntheticum, herba Dendrobii, cortex Lycii and Ficus Simplicissima, heating and stirring again, cooling to normal temperature, standing, and filtering to obtain radix Arnebiae oil. Clinical effect experiments for treating patients with poisonous insect bites show that the cure rate can reach 90 percent at most, the cure rate can reach 76 percent for patients with traumatic injuries and joint swelling and pain, and the lithospermum oil can treat diseases such as burns and scalds, necrosis removal and granulation promotion, lumbar muscle strain and the like, but the preparation raw materials have higher cost and the preparation condition has high requirements.

CN109700720A discloses an infant care cream and a preparation method thereof. The infant care cream mainly comprises propylene glycol, xanthan gum, allantoin, fatty alcohol, glyceryl stearate/PFG 100-stearate, phytosterol ester, medical vaseline, vitamin E acetate, polydimethylsiloxane, ammonium acryloyldimethyl taurate/vinyl pyrrolidone copolymer, alkanna tinctoria root extract, menthol, borneol, nicotinamide and the like. The preparation method comprises heating propylene glycol, xanthan gum and medical vaseline in water phase pot, heating span 60, Tween 60 and fatty alcohol in oil phase pot, mixing the obtained products, cooling to 40 deg.C, adding the rest materials, mixing, stirring, and sieving to obtain the final product. Experiments are carried out on infants (less than 2 years old) with eczema, the cure rate reaches 96% at most, the loss rate of the menthol after the infants are stored for 1 month reaches 7%, the preparation steps are complicated, the infants cannot be stored for a long time, and the failure rate is high.

In order to research the lithospermum erythrorhizon nursing ointment which is mild and non-irritant to skin, research personnel carry out a large amount of research, and the existing lithospermum erythrorhizon ointment also has the defects of complex preparation method, short storage period, irritation to skin and the like, so that the lithospermum erythrorhizon ointment which is mild and non-irritant to skin, and capable of sterilizing and diminishing inflammation and the preparation method thereof are urgently needed to be provided.

Disclosure of Invention

In view of the above-mentioned drawbacks of the background art, the invention provides a lithospermum nursing cream and a preparation method thereof, and the prepared lithospermum nursing cream has good sterilization and anti-inflammation effects, good repairing and beautifying effects on skin, particularly good relief effects on mosquito bites, chapped skin and the like, and has an obvious skin nursing effect.

In order to achieve the purpose, the invention adopts the following technical scheme:

a lithospermum nursing cream comprises the following raw materials: petrolatum, mineral oil, caprylic/capric triglyceride, shea butter, alkanna tinctoria root, dimethiconol, beeswax, hydrogenated castor oil, glyceryl behenate, triglycerides of C10-18 fatty acids, microcrystalline wax, canola oil, glyceryl stearate, vitamin E esters, olive oil, plant extracts, phytosterol oleate, tocopheryl acetate and menthol.

Further, the lithospermum nursing paste comprises the following raw materials in percentage by weight: 30-40% of petrolatum, 20-30% of mineral oil, 6-10% of caprylic/capric triglyceride, 3-8% of shea butter, 5-9% of radix Arnebiae, 5-8% of dimethiconol, 4-7% of white beeswax, 3-6% of hydrogenated castor oil, 2-5% of glyceryl behenate, 2-5% of C10-18 triglyceride, 2-5% of microcrystalline wax, 2-5% of rapeseed oil, 2-3% of glyceryl stearate, 0.5-1.0% of vitamin E ester, 1.5-5% of olive oil, 0.5-2% of plant extract, 0.5-1.0% of phytosterol oleate, 0.3-0.5% of tocopherol acetate and 0.1-0.5% of menthol.

Further, the weight ratio of the alkanna tinctoria roots, the brassica campestris oil and the phytosterol oleate is 10-18: 4-10: 1.

preferably, the lithospermum nursing cream comprises the following raw materials in percentage by weight: petrolatum 33%, mineral oil 22%, caprylic/capric triglyceride 8%, shea butter 4.5%, alkanna tinctoria root 6%, dimethiconol 5%, white beeswax 4%, hydrogenated castor oil 3%, glyceryl behenate 2%, C10-18 triglycerides, microcrystalline wax 2%, canola oil 3%, glyceryl stearate 2%, vitamin E ester 0.5%, olive oil 1.5%, plant extract 0.5%, phytosterol oleate 0.5%, tocopheryl acetate 0.3% and menthol 0.2%.

Further, the radix Arnebiae is radix Arnebiae in Xinjiang.

Further, the plant extract is one or more of scutellaria root, glycyrrhiza glabra root, perilla seed, kochia fruit, magnolia biondii bud/flower, dictamnus dasycarpus root, centella asiatica, peony root, divaricate saposhnikovia root and sweet almond, and preferably one or more of centella asiatica, divaricate saposhnikovia root and sweet almond.

The invention also provides a preparation method of the lithospermum nursing paste, which comprises the following steps:

(1) mixing petrolatum, mineral oil, microcrystalline wax, shea butter, glyceryl behenate and glyceryl stearate, and stirring to obtain a mixture 1;

(2) adding white beeswax, hydrogenated castor oil, dimethiconol, C10-18 fatty acid triglycerides, caprylic/capric triglyceride and vitamin E ester into the mixture 1 obtained in the step (1), mixing and stirring to obtain a mixture 2;

(3) mixing radix Arnebiae, Brassica campestris seed oil and oleum Olivarum, soaking, and filtering to obtain arnebia oil;

(4) adding the lithospermum oil obtained in the step (3) into the mixture 2 obtained in the step (2), mixing and stirring to obtain a mixture 3;

(5) adding the plant extract, the phytosterol oleate, the tocopherol acetate and the menthol into the mixture 3 obtained in the step (4), mixing and stirring to obtain a mixture 4;

(6) and cooling the mixture 4, and aging to obtain the lithospermum nursing paste.

Further, the stirring temperature in the step (1) is 65-75 ℃ and the stirring time is 15-25 minutes.

Further, the stirring temperature in the step (2) is 70-80 ℃ and the time is 10-15 minutes.

Further, the soaking temperature in the step (3) is 55-65 ℃ for 1.5-2 days, then the temperature is reduced to 45-55 ℃, and the soaking is carried out for 5-6 days.

Further, the stirring temperature in the step (4) is 55-65 ℃ and the stirring time is 6-8 days.

Further, the stirring temperature in the step (5) is 75-85 ℃ and the stirring time is 25-30 minutes.

Further, the temperature of the temperature reduction in the step (6) is 55-65 ℃, and the aging time is 1-2 hours.

Compared with the prior art, the invention has the beneficial effects that:

(1) the lithospermum oil is extracted by selecting high-quality Xinjiang soft lithospermum root and matching with vegetable oil such as olive oil, rape seed oil and the like through a special process, and the washing and the stability of active ingredients of the lithospermum are ensured to the maximum extent.

(2) Various solid and liquid grease, wax and the like are selected to be mixed to prepare a fresh and easily-smeared paste, and the use is convenient.

(3) The skin sensitivity problems of dry skin, pruritus, chap, red swelling and the like can be effectively solved by adding the phytosterol oleate and various plant extracting solutions.

(4) The lithospermum nursing cream disclosed by the invention has the moisturizing effect, and can be used for improving the brightness of the skin, improving the dry state of the skin and improving the elasticity of the skin.

(5) The lithospermum nursing cream has the effects of sterilizing and diminishing inflammation, and can be used for eliminating mosquito and insect bite marks and skin red and swollen and chapped marks.

Detailed Description

For a better understanding of the present invention, the present invention is further described in conjunction with the following specific examples, wherein the terminology used in the examples is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention.

The raw material sources are as follows:

the Xinjiang soft alkanna tinctoria root is purchased from Suzhou Chinese medicinal material company;

the brassica seed oil is purchased from the company AAK of Sweden;

phytosterol oleate was purchased from shanghai huixin;

the other raw materials are common commercial products, so that the source of the raw materials is not particularly limited.

Example 1

The lithospermum nursing paste comprises the following raw materials in percentage by weight: 40% petrolatum, 20% mineral oil, 6% caprylic/capric triglyceride, 3.5% shea butter, 5% arnica root, 5% dimethiconol, 4% white beeswax, 3% hydrogenated castor oil, 2% glyceryl behenate, 2% C10-18 triglycerides, 2% microcrystalline wax, 2% canola oil, 2% glyceryl stearate, 0.5% vitamin E ester, 1.5% olive oil, 0.5% centella asiatica extract, 0.5% phytosterol oleate, 0.3% tocopheryl acetate and 0.2% menthol.

The preparation method of the lithospermum nursing paste comprises the following steps:

(1) mixing and stirring petrolatum, mineral oil, microcrystalline wax, shea butter, glyceryl behenate and glyceryl stearate, wherein the stirring temperature is 65 ℃, and the stirring time is 15 minutes, so as to obtain a mixture 1;

(2) adding white beeswax, hydrogenated castor oil, dimethiconol, C10-18 fatty acid triglycerides, caprylic/capric triglyceride and vitamin E ester into the mixture 1 obtained in the step (1), mixing and stirring at the temperature of 70 ℃ for 10 minutes to obtain a mixture 2;

(3) mixing radix Arnebiae, Brassica campestris oil and oleum Olivarum, soaking at 55 deg.C for 1.5 days, cooling to 45 deg.C, soaking for 5 days, and filtering to obtain oleum Arnebiae;

(4) adding the lithospermum oil obtained in the step (3) into the mixture 2 obtained in the step (2), mixing and stirring at the stirring temperature of 55 ℃ for 6 days to obtain a mixture 3;

(5) adding centella asiatica extract, phytosterol oleate, tocopheryl acetate and menthol into the mixture 3 obtained in the step (4), mixing and stirring at the stirring temperature of 75 ℃ for 25 minutes to obtain a mixture 4;

(6) and cooling the mixture 4 at 55 ℃, and aging for 1 hour to obtain the lithospermum nursing paste.

Example 2

The lithospermum nursing paste comprises the following raw materials in percentage by weight: petrolatum 30%, mineral oil 27%, caprylic/capric triglyceride 6%, shea butter 3.5%, arnica root 5%, dimethiconol 5%, white beeswax 4%, hydrogenated castor oil 3%, glyceryl behenate 2%, C10-18 fatty acid triglycerides 2%, microcrystalline wax 2%, canola oil 5%, glyceryl stearate 2%, vitamin E ester 0.5%, olive oil 1.5%, centella asiatica extract 0.5%, phytosterol oleate 0.5%, tocopheryl acetate 0.3% and menthol 0.2%.

(1) mixing and stirring petrolatum, mineral oil, microcrystalline wax, shea butter, glyceryl behenate and glyceryl stearate, wherein the stirring temperature is 75 ℃, and the stirring time is 20 minutes, so that a mixture 1 is obtained;

(2) adding white beeswax, hydrogenated castor oil, dimethiconol, C10-18 fatty acid triglycerides, caprylic/capric triglyceride and vitamin E ester into the mixture 1 obtained in the step (1), mixing and stirring at the stirring temperature of 75 ℃ for 15 minutes to obtain a mixture 2;

(3) mixing radix Arnebiae, Brassica campestris oil and oleum Olivarum, soaking at 55 deg.C for 2 days, cooling to 45 deg.C, soaking for 6 days, and filtering to obtain oleum Arnebiae;

(4) adding the lithospermum oil obtained in the step (3) into the mixture 2 obtained in the step (2), mixing and stirring at the stirring temperature of 60 ℃ for 6 days to obtain a mixture 3;

(5) adding centella asiatica extract, phytosterol oleate, tocopheryl acetate and menthol into the mixture 3 obtained in the step (4), mixing and stirring at the stirring temperature of 80 ℃ for 25 minutes to obtain a mixture 4;

Example 3

The lithospermum nursing paste comprises the following raw materials in percentage by weight: petrolatum 30%, mineral oil 20%, caprylic/capric triglyceride 6%, shea butter 3%, arnica oil 9%, arnica root 9%, dimethiconol 5%, white beeswax 4%, hydrogenated castor oil 3.5%, glyceryl behenate 2%, C10-18 fatty acid triglycerides 3%, microcrystalline wax 3%, canola oil 5%, glyceryl stearate 2%, vitamin E ester 0.5%, olive oil 1.5%, centella asiatica extract 1.0%, phytosterol oleate 0.5%, tocopheryl acetate 0.5% and menthol 0.5%.

(1) mixing and stirring petrolatum, mineral oil, microcrystalline wax, shea butter, glyceryl behenate and glyceryl stearate, wherein the stirring temperature is 75 ℃, and the stirring time is 25 minutes, so that a mixture 1 is obtained;

(2) adding white beeswax, hydrogenated castor oil, dimethiconol, C10-18 fatty acid triglycerides, caprylic/capric triglyceride and vitamin E ester into the mixture 1 obtained in the step (1), mixing and stirring at the stirring temperature of 80 ℃ for 15 minutes to obtain a mixture 2;

(3) mixing radix Arnebiae, Brassica campestris oil and oleum Olivarum, soaking at 65 deg.C for 2 days, cooling to 55 deg.C, soaking for 6 days, and filtering to obtain oleum Arnebiae;

(4) adding the lithospermum oil obtained in the step (3) into the mixture 2 obtained in the step (2), mixing and stirring at the stirring temperature of 65 ℃ for 8 days to obtain a mixture 3;

(5) adding the centella asiatica extract, the phytosterol oleate, the tocopherol acetate and the menthol into the mixture 3 obtained in the step (4), mixing and stirring at the stirring temperature of 85 ℃ for 30 minutes to obtain a mixture 4;

(6) and cooling the mixture 4 at 65 ℃, and aging for 2 hours to obtain the lithospermum nursing paste.

Example 4

The lithospermum nursing paste comprises the following raw materials in percentage by weight: petrolatum 32.5%, mineral oil 23%, caprylic/capric triglyceride 6%, shea butter 3%, arnica oil 9%, dimethicone 5%, white beeswax 5%, hydrogenated castor oil 3%, glyceryl behenate 2%, C10-18 fatty acid triglycerides 2%, microcrystalline wax 2%, canola oil 2%, glyceryl stearate 2%, vitamin E ester 0.5%, olive oil 1.5%, centella asiatica extract 0.5%, phytosterol oleate 0.5%, tocopheryl acetate 0.3% and menthol 0.2%.

(1) mixing and stirring petrolatum, mineral oil, microcrystalline wax, shea butter, glyceryl behenate and glyceryl stearate, wherein the stirring temperature is 70 ℃, and the stirring time is 25 minutes, so that a mixture 1 is obtained;

(3) mixing radix Arnebiae, Brassica campestris oil and oleum Olivarum, soaking at 60 deg.C for 2 days, cooling to 50 deg.C, soaking for 5 days, and filtering to obtain oleum Arnebiae;

(4) adding the lithospermum oil obtained in the step (3) into the mixture 2 obtained in the step (2), mixing and stirring at the stirring temperature of 60 ℃ for 8 days to obtain a mixture 3;

(5) adding centella asiatica extract, phytosterol oleate, tocopheryl acetate and menthol into the mixture 3 obtained in the step (4), mixing and stirring at the stirring temperature of 75 ℃ for 30 minutes to obtain a mixture 4;

(6) and cooling the mixture 4 at 55 ℃, and aging for 2 hours to obtain the lithospermum nursing paste.

Example 5

The lithospermum nursing paste comprises the following raw materials in percentage by weight: petrolatum 33%, mineral oil 22%, caprylic/capric triglyceride 8%, shea butter 4.5%, arnica root 6%, dimethiconol 5%, white beeswax 4%, hydrogenated castor oil 3%, glyceryl behenate 2%, C10-18 fatty acid triglycerides 2%, microcrystalline wax 2%, canola oil 3%, glyceryl stearate 2%, vitamin E ester 0.5%, olive oil 1.5%, centella asiatica extract 0.5%, phytosterol oleate 0.5%, tocopheryl acetate 0.3% and menthol 0.2%.

(1) mixing and stirring petrolatum, mineral oil, microcrystalline wax, shea butter, glyceryl behenate and glyceryl stearate, wherein the stirring temperature is 70 ℃, and the stirring time is 20 minutes, so that a mixture 1 is obtained;

(3) mixing radix Arnebiae, Brassica campestris oil and oleum Olivarum, soaking at 60 deg.C for 2 days, cooling to 55 deg.C, soaking for 6 days, and filtering to obtain oleum Arnebiae;

(6) and cooling the mixture 4 to 60 ℃, and aging for 1 hour to obtain the lithospermum nursing paste.

Comparative example 1

The lithospermum nursing paste comprises the following raw materials in percentage by weight: petrolatum 41.5%, mineral oil 19%, caprylic/capric triglyceride 5%, shea butter 8.5%, arnica root 2.5%, dimethiconol 5%, white beeswax 3%, hydrogenated castor oil 3%, glyceryl behenate 1%, C10-18 triglyceride 1%, microcrystalline wax 1%, canola oil 1%, glyceryl stearate 5%, vitamin E ester 0.5%, olive oil 1.0%, centella asiatica extract 1%, phytosterol oleate 0.3%, tocopheryl acetate 0.1% and menthol 0.6%.

Other sources of raw materials and preparation method were the same as in example 5.

Comparative example 2

The lithospermum nursing paste comprises the following raw materials in percentage by weight: 28% petrolatum, 17% mineral oil, 5% caprylic/capric triglyceride, 8.5% shea butter, 10% arnica root, 4% dimethiconol, 3% white beeswax, 2% hydrogenated castor oil, 6% glyceryl behenate, 6% C10-18 triglycerides, 1% microcrystalline wax, 6% canola oil, 1% glyceryl stearate, 0.3% vitamin E ester, 0.5% olive oil, 0.5% centella asiatica extract, 0.4% phytosterol oleate, 0.2% tocopheryl acetate and 0.6% menthol.

Comparative example 3

Wherein the weight ratio of the arnebia euchroma root to the brassica oil to the phytosterol oleate is 12: 2: 1 (the total weight of arnebia euchroma root, brassica oil and phytosterol oleate is the same as in example 5).

Other sources and contents of raw materials and preparation method are the same as those of example 5.

Comparative example 4

The difference from the embodiment 5 of the application is that in the preparation method of the lithospermum nursing paste, in the step (3), the arnebia euchroma root, the brassica oil and the olive oil are mixed, soaked at the soaking temperature of 60 ℃ for 8 days, and filtered to obtain the lithospermum oil;

Comparative example 5

The difference from the embodiment 5 of the application is that in the preparation method of the lithospermum nursing paste, the stirring temperature in the step (2) is 65 ℃, the soaking temperature in the step (3) is 50 ℃, the soaking is carried out for 2 days, then the temperature is reduced to 40 ℃, the soaking is carried out for 6 days, the lithospermum oil is obtained after the filtration, and the stirring temperature in the step (5) is 65 ℃;

Comparative example 6

The difference from the embodiment 5 of the application is that in the preparation method of the lithospermum nursing paste, the stirring temperature in the step (1) is 80 ℃, the soaking temperature in the step (3) is 70 ℃, the soaking is carried out for 2 days, then the temperature is reduced to 65 ℃, the soaking is carried out for 6 days, the lithospermum oil is obtained after the filtration, and the stirring temperature in the step (5) is 90 ℃;

Comparative example 7

Example 5 in patent CN 108096103B.

Test experiments:

1. testing the extraction rate of alkannin:

the test method comprises the following steps: the content of shikonin in the arnebia oil directly influences the action effect of the arnebia oil, the extraction rate of shikonin in the arnebia oil in the above examples and comparative examples is respectively tested, and the content of shikonin in the arnebia oil is tested by an HPLC method.

The extraction rate (%) of shikonin was found in table 1, i.e., the weight (g) of shikonin/the weight (g) of shikonin oil.

Testing an instrument: high performance liquid chromatograph LC-10A (Shimadzu, Japan).

The chromatographic conditions include: a chromatographic column: shimadzu Shim-packVP-ODS column (4.6 mm. times.250 mm); mobile phase: methanol-0.025 mol/L phosphoric acid (85: 15); flow rate: 1.0 mL/min; detection wavelength: 516 nm; column temperature: 25 ℃; sample introduction volume: 20 μ L.

Table 1:

the experiments show that the extraction rate of the shikonin in the lithospermum oil in the embodiment of the invention is more than 90%, wherein the extraction rate of the shikonin in the lithospermum oil in the embodiment 5 is 95%, which is the optimal embodiment; the setting of the comparative example is at least one factor out of the claimed range, and experimental data show that the extraction rate of the shikonin in the lithospermum oil is obviously reduced, so the embodiment of the invention has better effect.

2. Skin moisture test:

(1) testing the population: age and sex were randomized, and the above examples and comparative examples were tested separately, and the results are shown in table 2.

The test was carried out using a skin moisture tester (CK company, germany), and the test site: inside the arm.

The test flow comprises the following steps: the subjects were divided into 12 groups of 11 persons, and after cleaning the inner skin of the arm, the ointment was applied, and the moisture changes before and after use were measured, respectively, and the results were averaged, and are shown in table 2.

Table 2:

the experiments show that after the ointment disclosed by the invention is used in the embodiment, the moisture content of the skin smearing part for 2 hours is greatly improved compared with the moisture content before the ointment is used, the moisture content of the skin smearing part for 2 hours in the comparative example is smaller than the moisture content in the embodiment, the significance of the claimed range of the invention is highlighted, and the moisturizing effect of the embodiment 5 is optimal, so that the lithospermum nursing ointment disclosed by the invention has a remarkable moisturizing effect.

3. Detecting mosquito bites:

the test process comprises the steps of respectively applying the ointment to 30 test persons with skin mosquito bites in each example or comparative example for 1-2 times per day, continuously using the ointment for 7 days, and respectively taking an average value according to the test standard that ① is cured, the symptoms of the skin bite part disappear, ② is effective, the symptoms of the skin bite part are relieved, ③ is ineffective, the symptoms of the skin bite part are not acted, and the results are shown in a table 3.

Table 3:

the experiments show that the total effective rates in the examples are all more than 96.67 percent, the total effective rates in the comparative examples are all lower than those in the examples, at least one factor of the settings of the comparative examples 1 to 5 is out of the range claimed by the invention, so the significance of the range claimed by the invention is highlighted, the comparative examples 6 to 7 are target products prepared by the prior art, and the effect of treating mosquito bites is found to be lower than that in the examples by comparison; in addition, the subject in the embodiment 5 is healed, the total effective rate reaches 100%, and the shikonin nursing ointment is the best embodiment, so the shikonin nursing ointment has obvious effects of treating skin and repairing wounds caused by insect bites and stings.

4. Skin chap test:

the test process comprises the steps of applying the ointment on a test population, namely patients with local chapped skin, applying the ointment on 30 patients in each example or comparative example for 1-2 times per day for 7 days continuously, wherein the average value is obtained according to the test standard that ① is cured, namely, the chapped skin disappears, ② is effective, the chapped skin is relieved, ③ is ineffective, no effect is caused on the chapped skin, and the results are shown in Table 4.

Table 4:

through the experiments, the total effective rate in the examples is more than 96.67 percent, the total effective rate in the comparative examples is lower than that in the examples, at least one factor of the arrangement of the comparative examples 1 to 5 is out of the range claimed by the invention, so the significance of the range claimed by the invention is highlighted, and the comparative examples 6 to 7 are target products prepared by the prior art, and the effect of treating the chapped skin is lower than that in the examples through comparison; in addition, the testers in the embodiment 5 are cured, the total effective rate is 100%, and the best embodiment is that the lithospermum nursing cream has obvious effects of treating chapped skin, red swelling and the like.

Claims

1. A lithospermum nursing cream is characterized in that:

the lithospermum nursing paste comprises the following raw materials: petrolatum, mineral oil, caprylic/capric triglyceride, shea butter, alkanna tinctoria root, dimethiconol, beeswax, hydrogenated castor oil, glyceryl behenate, triglycerides of C10-18 fatty acids, microcrystalline wax, canola oil, glyceryl stearate, vitamin E esters, olive oil, plant extracts, phytosterol oleate, tocopheryl acetate and menthol.

2. The lithospermum erythrorhizon nursing cream as claimed in claim 1, wherein:

the lithospermum nursing paste comprises the following raw materials in percentage by weight: 30-40% of petrolatum, 20-30% of mineral oil, 6-10% of caprylic/capric triglyceride, 3-8% of shea butter, 5-9% of radix Arnebiae, 5-8% of dimethiconol, 4-7% of white beeswax, 3-6% of hydrogenated castor oil, 2-5% of glyceryl behenate, 2-5% of C10-18 triglyceride, 2-5% of microcrystalline wax, 2-5% of rapeseed oil, 2-3% of glyceryl stearate, 0.5-1.0% of vitamin E ester, 1.5-5% of olive oil, 0.5-2% of plant extract, 0.5-1.0% of phytosterol oleate, 0.3-0.5% of tocopherol acetate and 0.1-0.5% of menthol.

3. The lithospermum erythrorhizon nursing cream as claimed in claim 2, wherein: the weight ratio of the alkannin root to the brassica seed oil to the phytosterol oleate is 10-18: 4-10: 1.

4. the lithospermum erythrorhizon nursing cream as claimed in claim 1, wherein: the radix Arnebiae is radix Arnebiae of Sinkiang.

5. The lithospermum erythrorhizon nursing cream as claimed in claim 1, wherein: the plant extract is one or more of radix Scutellariae, radix Glycyrrhiza Glabra, fructus Perillae, Kochiae fructus, flos Magnoliae, radix Dictamni, herba Centellae, radix moutan, radix Saposhnikoviae, and sweet almond.

6. A process for preparing a arnebia euchroma (Royle) Johnst care cream as claimed in any one of claims 1 to 5, which comprises the steps of:

(1) mixing petrolatum, mineral oil, microcrystalline wax, shea butter, glyceryl behenate, glyceryl stearate and vitamin E ester, and stirring to obtain a mixture 1;

(2) adding white beeswax, hydrogenated castor oil, dimethiconol, C10-18 fatty acid triglycerides and caprylic/capric triglyceride into the mixture 1 obtained in the step (1), mixing and stirring to obtain a mixture 2;

(6) and cooling and aging the mixture 4 to obtain the lithospermum nursing paste.

7. The method of claim 6, wherein: the stirring temperature in the step (1) is 65-75 ℃, and the stirring time is 15-25 minutes; the stirring temperature in the step (2) is 70-80 ℃, and the stirring time is 10-15 minutes.

8. The method of claim 6, wherein: and (3) soaking at 55-65 ℃ for 1.5-2 days, cooling to 45-55 ℃, and soaking for 5-6 days.

9. The method of claim 6, wherein: the stirring temperature in the step (4) is 55-65 ℃, and the stirring time is 6-8 days.

10. The method of claim 6, wherein: the stirring temperature in the step (5) is 75-85 ℃, and the stirring time is 25-30 minutes; the temperature of the temperature reduction in the step (6) is 55-65 ℃, and the aging time is 1-2 hours.