CN113750015B - Acne-removing composition with acne mark and acne scar removing effects and preparation method thereof - Google Patents
Acne-removing composition with acne mark and acne scar removing effects and preparation method thereof Download PDFInfo
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- CN113750015B CN113750015B CN202111221741.9A CN202111221741A CN113750015B CN 113750015 B CN113750015 B CN 113750015B CN 202111221741 A CN202111221741 A CN 202111221741A CN 113750015 B CN113750015 B CN 113750015B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The application discloses an acne-removing composition with acne mark and acne scar removing effects, and relates to the technical field of skin care products. The composition comprises radix Scutellariae extract, cortex Phellodendri extract, rhizoma Coptidis extract and herba Centellae extract. The preparation method comprises the following steps: (1) Drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, and herba Centellae, and pulverizing to obtain plant powder; (2) Adding water, butanediol and 1, 2-pentanediol into the plant powder obtained in the step (1), extracting, and filtering. The composition has effects of removing acne mark, removing acne scar, controlling oil and removing acne. The purpose, the action route and the mechanism of each component in the composition are different, and the components show the best synergistic effect when the dosage proportion is proper. The preparation method can improve the active ingredients of the extract, and has good effect.
Description
Technical Field
The application relates to the technical field of skin care products, in particular to an acne removing composition with acne mark removing and acne scar removing effects.
Background
The acne is also called acne and pimple in medicine, commonly called acne, pimple, etc., and is a very common chronic inflammation of sebaceous glands and hair follicles. It is good for puberty men and women, especially forehead, cheek and chin, and also found in the rich sebaceous gland distribution of chest, shoulder and back. Under normal conditions, sebaceous glands secrete proper amounts of grease to reach the skin surface to achieve the effect of moisturizing the skin. When the sebaceous glands of the skin are stimulated by stimulus factors (androgens, spicy greasy foods, menses, mental stress and the like), excessive sebum is secreted, the horny layer is out of order, skin metabolism is disordered, old and waste horny substances are accumulated, sebum cannot be smoothly discharged, hair follicles are blocked and the like, a closed environment is formed after the hair follicles are blocked, acne is formed, the hair follicles are in an anoxic state, anaerobic propionibacterium acnes are used for manufacturing a growing environment, propionibacterium acnes start to excessively reproduce, inflammatory substances are accumulated by metabolites of propionibacterium acnes, inflammatory acne is formed, acne marks are always left on the skin after acne is eliminated due to pigmentation caused by inflammation, and skin cells are simultaneously damaged by inflammatory reaction, so that scars are generated. Acne is not only a somatic disease, but also a physical and psychological disease which cannot be ignored, and the generation of acne, acne marks and acne scars often has certain influence on social, psychological, emotional and other aspects of patients. Many products for removing acne sold in the market at present mainly take sterilization and anti-inflammation as main treatments, but the products cannot well remove or relieve acne marks and acne scars generated after acne is removed, so that an efficacy product with acne mark removal and acne scar removal effects is urgently needed in the market, and the requirement on multiple efficacy of the acne removal product is met.
Chinese patent application CN201910615975.8 discloses a composition for whitening, removing spots, removing acnes and improving skin, which is prepared by mixing component a, component B, component C, component D, component E, component F, component G and component H; the component A consists of the following components: deionized water, p-hydroxyacetophenone, purslane extract and allantoin; the component B consists of the following components: methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, petrolatum and caprylic/capric triglyceride; the component C is an ammonium acryloyldimethyl taurate/VP copolymer; the component D consists of the following components: deionized water, pearl powder and kuh-seng powder; the component E consists of the following components: yeast fermentation lysate filtrate, erythritol, butylene glycol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra root extract, chamomile extract, rosemary leaf extract, 1, 2-pentanediol, glycerol caprylate, octanoic acid, propylene glycol, hydrolyzed elastin, oat beta-glucan, oat kernel extract, coptis chinensis extract, salvia root extract, rhizoma atractylodis extract, dandelion extract, poria cocos extract, coix seed extract, hydroxyphenyl propionamide benzoic acid, glycolic acid, PEG-60 hydrogenated castor oil, ethylhexyl glycerol, glycerol caprylate, lactobacillus/pear juice fermentation product filtrate cortex Phellodendri extract, salix alba bark extract, radix rehmanniae extract, neem leaf extract, radix Scutellariae extract, herba Houttuyniae extract, semen glycines Indici extract, herba Taraxaci extract, fructus Cnidii extract, radix Puerariae extract, radix Angelicae sinensis root extract, cortex Phellodendri extract, radix Sophorae Flavescentis extract, kochiae fructus extract, fructus Zanthoxyli extract, radix Ginseng extract, arginine ferulate, 1-methylhydantoin-2-imide, corni fructus extract, menthol lactate, menthol, oleum Lavandula Angustifolia, borneolum Syntheticum, atractylodis rhizoma root powder, rhizoma Bletillae root powder, radix Ampelopsis powder, radix Paeoniae root powder, poria powder, bombyx Batryticatus extract; dandelion extract, cnidium fruit extract, kudzu vine root extract, angelica root extract, phellodendron bark extract, kuh-seng root extract, broom cypress fruit extract, pricklyash peel extract, ginseng root extract, arginine ferulate, 1-methylhydantoin-2-imide, dogwood extract, menthol lactate, menthol, lavender oil, borneol, bighead atractylodes rhizome root powder, bletilla tuber root powder, japanese ampelopsis root powder, paeonia root powder, poria cocos powder and stiff silkworm extract; the component F consists of the following components: deionized water and citric acid; the component G consists of the following components: deionized water and benzodenal ammonium; the component H is an ammonium acryloyldimethyl taurate/VP copolymer.
Chinese patent application CN201911177274.7 discloses an acne-removing liquid which comprises the following raw materials in parts by weight: 10 parts of radix curcumae, 30 parts of herba lycopi, 30 parts of chrysanthemum, 30 parts of poria cocos, 30 parts of periostracum cicada, 30 parts of cortex moutan, 30 parts of radix paeoniae rubra, 30 parts of coptis chinensis, huang Tong parts of radix scutellariae, 30 parts of honeysuckle, 30 parts of safflower, 30 parts of bighead atractylodes rhizome, 30 parts of rhizoma atractylodis, 30 parts of pearl powder, 30 parts of rose, 30 parts of rhizoma smilacis glabrae, 30 parts of eupatorium, 30 parts of ginseng, 30 parts of angelica sinensis, 30 parts of peach gum, 10 parts of ganoderma lucidum, 10 parts of borneol, 0.5 part of musk, 45 parts of balsam pear, 200 parts of centella asiatica extract and 200 parts of radix sophorae flavescentis extract.
The acne-removing composition in the prior art has more and more active ingredients, is easy to cause adverse reaction, and is prepared or extracted by adopting a conventional method during preparation, so that a large amount of active ingredients are lost. In view of the above, the present application provides a composition having the effects of eliminating acne marks and eliminating acne scarsAcne removingThe composition has simple components, and the preparation method can make the effective components rapidThe extract has higher active ingredients and better effect when dissolved in solvent.
Disclosure of Invention
The application aims to provide an acne-removing composition which has the effects of removing acne marks, removing acne scars, controlling oil and removing acnes. The purpose, the action route and the mechanism of each component in the composition are different, and the components show the best synergistic effect when the dosage proportion is proper. The preparation method can improve the active ingredients of the extract, and has good effect.
In order to achieve the above object, the present application has the following technical scheme:
in one aspect, the application provides an acne-removing composition with acne mark and acne scar removing effects, which comprises a radix scutellariae extract, a cortex phellodendri extract, a rhizoma coptidis extract and a centella extract.
Preferably, the acne-removing composition comprises the raw materials of radix scutellariae, cortex phellodendri, rhizoma coptidis and centella asiatica in a mass ratio of 1-10:1-10:1-10:1-10; further preferably, the mass ratio of the radix scutellariae, the cortex phellodendri, the rhizoma coptidis and the centella is 5:3:3:6.
"centella" refers to the whole plant of centella asiatica.
The baicalein, baicalin and other components contained in the baicalein disclosed by the application influence the metabolism of arachidonic acid through various links, and inhibit the generation of prostaglandin E (PGE) and Leukotriene (LT) to different degrees, so that the effects of dilating blood vessels by inflammatory mediators, increasing the permeability of blood vessel walls and chemotaxis of leucocytes are lightened; baicalin also has extremely high inhibitory activity on melanocytes, can remarkably inhibit the generation of lipid peroxide, and can relieve melanin pigmentation;
the cortex phellodendri has the anti-inflammatory effect, can directly resist the myobottom to relieve the acnes, can promote the generation of collagen to repair scars, combines the oxidation resistance of the cortex phellodendri and stabilizes the skin; the cortex Phellodendri contains berberine, phellodendrine, and has inhibiting effect on Staphylococcus aureus, staphylococcus albus, staphylococcus lemon, diplococcus pneumoniae, diplococcus meningitidis, streptococcus viridae, vibrio cholerae, bacillus diphtheriae, bacillus dysenteriae, pseudomonas aeruginosa, etc.
The coptis root contains a plurality of active ingredients such as coptisine, jatrorrhizine and the like. Has remarkable antibacterial effect on staphylococcus aureus, streptococcus pneumoniae producing ultra-broad-spectrum-beta lactamase and other gram-positive bacteria, pseudomonas aeruginosa, escherichia coli, drug-resistant acinetobacter baumannii, neisseria gonorrhoeae and other gram-negative bacteria, candida albicans and other fungi, and can balance grease.
The centella asiatica extract is rich in terpenoid, can obviously improve the content of collagen and cell layer fibronectin (the fibronectin is widely involved in the processes of cell migration, adhesion, proliferation, hemostasis, skin tissue repair and the like), can stimulate and promote the generation of type I collagen and type III collagen, activate fibroblast genes, and improve and repair the barrier function of skin; can promote wound healing and scar repair, and reduce inflammatory reaction. In addition, centella asiatica extract can reduce the production of pro-inflammatory mediators (IL-1, MMP-1) and improve and repair the self barrier function of skin.
In another aspect, the present application provides a method for preparing the above acne-removing composition, comprising the steps of:
(1) Drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, and herba Centellae, and pulverizing to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into the plant powder obtained in the step (1), extracting, and filtering.
Preferably, in the step (1), the pulverization means pulverization to 10 to 50 mesh.
Preferably, in the step (2), the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 10-30:30-70:30-70:1-10, and more preferably 17:50:50:5.
Preferably, in the step (2), the extraction adopts a low-temperature high-pressure difference method, specifically: regulating the temperature to 30-50deg.C, pressurizing to 50-100MPa, and soaking and extracting under stirring for 30-60 min.
The low temperature and high pressure difference method is characterized in that the loss of thermosensitive components can be avoided under the low temperature condition, the solvent is easier to permeate into the plant powder under the high pressure condition, the active ingredients are rapidly dissolved in the solvent, and the test proves that the active ingredients of the extract obtained by the low temperature and high pressure difference method are higher and the effect is better.
In still another aspect, the application also provides application of the acne-removing composition in cosmetics.
Preferably, in the application, the content of the acne removing composition in the cosmetic is 2-10wt%.
Finally, the application provides an oil-control acne-removing gel, which comprises the composition.
Preferably, the oil-control acne-removing gel comprises a phase A and a phase B, wherein the phase A comprises water, allantoin, disodium EDTA, polyacrylate crosslinked polymer-6, 1, 2-pentanediol, menthol and the composition; the phase B comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, cyclopentadimethicone, cyclohexasiloxane and dimethicone.
Further preferably, the oil control acne removal condensation comprises the following components:
the beneficial effects of the application are as follows:
(1) The acne-removing composition provided by the application has the effects of removing acne marks, removing acne scars, controlling oil and removing acne. The purpose, the action route and the mechanism of each component in the composition are different, and the components show the best synergistic effect when the dosage proportion is proper.
(2) The effective components are plant sources, have no irritation to skin, and are mild and safe.
(3) The low temperature and high pressure difference method is characterized in that the loss of thermosensitive components can be avoided under the low temperature condition, the solvent is easier to permeate into the plant powder under the high pressure condition, the active ingredients are rapidly dissolved in the solvent, and the test proves that the active ingredients of the extract obtained by the low temperature and high pressure difference method are higher and the effect is better.
Detailed Description
In order to make the technical means, the creation features, the achievement of the purpose and the effect of the present application easy to understand, the present application will be further elucidated with reference to the specific embodiments, but the following embodiments are only preferred embodiments of the present application, not all of them. Based on the examples in the embodiments, those skilled in the art can obtain other examples without making any inventive effort, which fall within the scope of the application. In the following examples, unless otherwise specified, the methods of operation used were conventional, the equipment used was conventional, and the materials used in the examples were the same. For process parameters or conditions not specifically noted, reference may be made to conventional techniques.
In the following examples, the term "Sanhuang acne-removing agent" is a composition prepared by the application, and comprises a baical skullcap root extract, a cortex phellodendri extract, a rhizoma coptidis root extract and a centella asiatica extract, and is abbreviated as "Sanhuang" because of containing the baical skullcap root extract, the cortex phellodendri extract and the rhizoma coptidis root extract.
Example 1
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis and herba Centellae, wherein the mass ratio of radix Scutellariae, cortex Phellodendri, rhizoma Coptidis and herba Centellae is 1:10:1:1; pulverizing to 50 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, placing into an extraction kettle, adjusting temperature to 30deg.C, pressurizing to 50MPa, soaking under stirring, extracting for 60 min, centrifuging, collecting supernatant, and filtering with 1000 mesh filter cloth.
Example 2
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis and herba Centellae, wherein the mass ratio of radix Scutellariae, cortex Phellodendri, rhizoma Coptidis and herba Centellae is 10:1:10:10; pulverizing to 50 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, placing into an extraction kettle, adjusting the temperature to 50deg.C, pressurizing to 100MPa, soaking under stirring, extracting for 30min, centrifuging, collecting supernatant, and filtering with 500 mesh filter cloth.
Example 3
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis and herba Centellae, wherein the mass ratio of radix Scutellariae, cortex Phellodendri, rhizoma Coptidis and herba Centellae is 5:3:3:6; pulverizing to 30 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, placing into an extraction kettle, adjusting temperature to 40deg.C, pressurizing to 80MPa, soaking under stirring, extracting for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 1
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Pulverizing radix Scutellariae to 30 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, placing into an extraction kettle, adjusting temperature to 40deg.C, pressurizing to 80MPa, soaking under stirring, extracting for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 2
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Pulverizing cortex Phellodendri bark to 30 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, placing into an extraction kettle, adjusting temperature to 40deg.C, pressurizing to 80MPa, soaking under stirring, extracting for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 3
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Pulverizing rhizoma Coptidis to 30 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, placing into an extraction kettle, adjusting temperature to 40deg.C, pressurizing to 80MPa, soaking under stirring, extracting for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 4
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Pulverizing herba Centellae to 30 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, placing into an extraction kettle, adjusting temperature to 40deg.C, pressurizing to 80MPa, soaking under stirring, extracting for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 5
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Drying purslane flower/leaf/stem, cortex phellodendri, coptis root and centella asiatica, wherein the mass ratio of purslane flower/leaf/stem, cortex phellodendri, coptis root and centella asiatica is 5:3:3:6; pulverizing to 30 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, placing into an extraction kettle, adjusting temperature to 40deg.C, pressurizing to 80MPa, soaking under stirring, extracting for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 6
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis and herba Centellae, wherein the mass ratio of radix Scutellariae, cortex Phellodendri, rhizoma Coptidis and herba Centellae is 5:3:3:6; pulverizing to 30 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, soaking at room temperature under stirring (without pressurization) for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 7
A preparation method of a Sanhuang acne-removing agent comprises the following steps:
(1) Drying radix Scutellariae, aloe, rhizoma Coptidis and herba Centellae, wherein the mass ratio of radix Scutellariae, aloe, rhizoma Coptidis and herba Centellae is 5:3:3:6; pulverizing to 30 mesh to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50:5; mixing, soaking at room temperature under stirring (without pressurization) for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Test example 1 Propionibacterium acnes-resistance effect
Propionibacterium acnes is the primary pathogen responsible for causing acne. Antibacterial experiments to verify the antibacterial effect of the composition of the application by using propionibacterium acnes as a bacterial model, antibacterial performance determination is performed on the compositions of examples 1-3 and comparative examples 1-7 according to GB15979-2002 "antibacterial Performance test method for dissolution antibacterial (antibacterial) products of Disposable sanitary articles sanitary Standard" appendix C4 ".
1) Test sample: the compositions described in examples 1-3 and comparative examples 1-7 were diluted to 2% dilutions, respectively.
2) Preparation of bacterial suspension: the propionibacterium acnes 24h culture is washed by 0.03mol/L phosphate buffer solution to prepare 104-106CFU/mL bacterial suspension.
3) 1g of test sample is respectively taken, 0.1mL of the bacterial suspension is added for uniform coating and mixing, timing is started, 9mL of 0.03mol/L phosphate buffer solution is added after 20min for full mixing, after proper dilution is carried out, 3 dilutions are taken, 1mL of the solution is respectively taken and placed in two parallel plates, and then the corresponding culture medium is added for culturing for 24 hours under the anaerobic condition at 36+/-1 ℃ for colony counting. The above test was repeated 3 times, averaged, and a blank control group was set.
The calculation formula of the bacteriostasis rate is as follows: x= (a-B)/a×100%, where X is the antibacterial rate, a is the average recovered colony of the blank control sample, and B is the average recovered colony of the test sample.
The efficacy evaluation criteria were: the antibacterial rate is more than or equal to 90 percent, which is obvious in effect; (2) the bacteriostasis rate is 40-90% and the effect is general; and (3) the antibacterial rate is less than 40 percent, which is no effect. The results are shown in the following table.
TABLE 1 antibacterial (Propionibacterium acnes) test results
| Group of | Propionibacterium acnes antibacterial ratio (%) | Efficacy evaluation |
| Example 1 | 90 | Obvious effect |
| Example 2 | 91 | Obvious effect |
| Example 3 | 94 | Obvious effect |
| Comparative example 1 | 42 | Effects are general |
| Comparative example 2 | 48 | Effects are general |
| Comparative example 3 | 53 | Effects are general |
| Comparative example 4 | 40 | Effects are general |
| Comparative example 5 | 42 | Effects are general |
| Comparative example 6 | 68 | Effects are general |
| Comparative example 7 | 40 | Effects are general |
As can be seen from Table 1, the compositions of examples 1-3 have remarkable antibacterial effects on Propionibacterium acnes, and the antibacterial effects of comparative examples 1-7 are general; experiments show that the radix scutellariae, cortex phellodendri, rhizoma coptidis and centella asiatica can obviously inhibit the proliferation of propionibacterium acnes when being combined and used by proper proportions, and the inhibition effect is better than that of the single use of the components; can effectively prevent or improve acne symptoms of skin.
Example 4
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 2.
Example 5
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 3.
Example 6
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 4.
Comparative example 8
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 5.
Comparative example 9
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 6.
Comparative example 10
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 7.
Comparative example 11
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 8.
Comparative example 12
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 9.
/>
Comparative example 13
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 10.
Test example 2 oil control and acne removal test
The oil control acne-removing gel prepared in examples 4 to 6, comparative examples 8 to 13 and blank control group was subjected to an evaluation of the oil control acne-removing efficacy. The blank was different from example 6 in that it did not contain a three-yellow anti-acne agent.
The oil control effect tester is a skin grease tester. The working principle of the adhesive tape is that a special adhesive tape is adopted, so that grease on the surface of the skin cuticle can be absorbed rapidly, the transmittance of the adhesive tape can be changed, and the grease content of the skin cuticle can be obtained by measuring the transmittance of the adhesive tape before and after use through a photometer built in an instrument.
The testing method comprises the following steps: 100 volunteers with oily skin and acne are summoned, and the volunteers are divided into 10 groups of 10 people, wherein one group uses oil control acne-removing gel of a blank control group, three groups use the oil control acne-removing gels prepared in examples 4-6 respectively, and six groups use the oil control acne-removing gels prepared in comparative examples 8-13 respectively, and the oil control acne-removing gel is used once a day in the morning and evening, the use amount is 0.2 g/time, and the oil control acne-removing gel is smeared on the face and is gently massaged until absorption. The fat content of the forehead part of the volunteer was measured with a skin fat tester every other week, each part was tested 3 times, and the average value was taken, and specific test records are shown in table 2. The acne removal condition is recorded every other week, the acne number is reduced by more than 1/3 by comparison with the photo before the product is used, and the specific test record is shown in the table below.
TABLE 11 oil control test record table
TABLE 12 anti-acne test record chart
From tables 11 and 12, the oil-control acne-removing gel prepared by the embodiment of the application has good oil-control acne-removing effect; and the effects of acne removal of the baikal skullcap root, the cortex phellodendri, the rhizoma coptidis root and the centella asiatica are better than those of acne removal of the baikal skullcap root, the cortex phellodendri, the rhizoma coptidis root and the centella asiatica when the baikal skullcap root, the cortex phellodendri and the rhizoma centella asiatica are combined and used by proper proportions.
Comparative example 14
The acne-removing conditioning essence (containing salicylic acid) with better public praise in the market is selected
Comparative example 15
Centella asiatica acne-removing paste with better public praise in market
Test example 3 anti-acne mark and anti-acne scar test
The oil control acne-removing gel prepared in examples 4 to 6 and comparative examples 8 to 13 and the oil control acne-removing gel prepared in the blank control group and the commercial acne-removing products of comparative examples 14 to 15 were subjected to acne mark and acne scar removal efficacy evaluation, wherein the blank control group is different from example 6 in that the three-yellow acne-removing agent is not contained.
The testing method comprises the following steps: 120 volunteers with new acne marks and acne scars (the acne marks and the acne scars are generated within one month) are summoned, the volunteers are divided into 10 groups, 10 people are respectively used in one group, the oil control acne-removing condensation of a blank control group is used, the oil control acne-removing condensation prepared in examples 4-6 is respectively used in three groups, the oil control acne-removing condensation prepared in comparative examples 8-13 is respectively used in six groups, the commercial acne-removing products in comparative examples 14-15 are respectively used in two groups, the use amount is 0.2 g/time in the morning and evening, and the volunteers are smeared on the face and gently massaged until absorption. Comparison was made by volunteers for signs of acne marks and scars after one month of use of the product, and specific test recordings are shown in the following table.
TABLE 13 acne mark removal test record form
TABLE 14 test record table for removing acne scars
From 13 and 14, the acne-removing conditioning essence (containing salicylic acid) of comparative example 14 has better acne mark removing effect and poorer acne mark removing effect; the centella asiatica acne-removing paste of comparative example 15 has good acne-removing effect and poor acne mark-removing effect; the oil-control acne-removing gel prepared by the embodiment of the application has good acne mark removing and acne scar removing effects, and has better acne removing effects than the independent use of each component.
Test example 4 irritation test (Patch test)
Test sample: the oil-control acne-removing gel prepared in examples 4-6 and the commercial acne-removing products of comparative examples 14-15.
The subject: 30 volunteers (each test sample used the same batch of subjects) were selected;
the test method comprises the following steps: a closed test is adopted, 0.02g of test sample is placed in a patch device, the patch device is applied to the bent side of the arm of a tested object by using a hypoallergenic adhesive tape, the test area is at least 5X 5cm, the arm of the tested object is straightened when the patch device is applied, the test sample is applied from the lower part to the upper part, the adhesive tape is slightly pressed by the palm to discharge air, the patch device is tightly adhered to the skin for 24 hours, and a blank control group is a test sample which is not used.
Observation results: after removing the patch device for 30min, the patch device was interpreted according to the following interpretation standard, and the statistical test results are shown in the following table.
Interpretation criteria: (one) negative reaction; suspicious reaction: only mild erythema; (+) weak positive: erythema, infiltration, and possibly small papules; (++) strong positive: erythema, infiltration, papules, blisters; (+ ++ + electrode) strong positive: erythema, infiltration, papules, blisters and bullae.
TABLE 15 irritation test record
| Test item | Negative/rate | Suspicious response/Rate | Weak positive/rate | Strong positive/rate | Extremely strong positivity/Rate | Positive rate |
| Example 4 | 30/100％ | 0/0 | 0/0 | 0/0 | 0/0 | 0 |
| Example 5 | 30/100％ | 0/0 | 0/0 | 0/0 | 0/0 | 0 |
| Example 6 | 30/100％ | 0/0 | 0/0 | 0/0 | 0/0 | 0 |
| Comparative example 14 | 16/53.33％ | 12/40％ | 2/6.67％ | 0/0 | 0/0 | 46.67％ |
| Comparative example 15 | 28/93.33％ | 2/6.67％ | 0/0 | 0/0 | 0/0 | 6.67％ |
As is clear from the table, the oil-control acne-removing gel prepared in the examples 4-6 has low skin sensitization, and no positive reaction is detected in 30 subjects, so that the composition has no stimulation to skin, mild ingredients and safety.
In summary, the three-yellow acne-removing agent compositions obtained in examples 1 to 3 have more outstanding skin oil secretion reduction and better acne-removing effects than the comparative examples, and especially the effect of example 3 is most ideal; experimental results show that the composition can show the optimal oil control and acne removal effects through proper proportion collocation combination, and simultaneously has the optimal acne mark removal and acne scar removal effects. The analysis shows that the efficacy of the composition is due to the fact that the purpose of action, the action route and the mechanism of each component in the composition are different, and the components show the best synergistic effect when the dosage proportion is proper; and experiments prove that the composition has no stimulation to skin, mild ingredients and safety.
The foregoing description of the preferred embodiments of the application is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the application.
Claims (9)
1. An acne-removing composition with acne mark and acne scar removing effects is characterized by comprising radix scutellariae extract, cortex phellodendri extract, rhizoma coptidis extract and centella asiatica extract in a mass ratio of 1-10:1-10:1-10:1-10;
the preparation method comprises the following steps:
(1) Drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, and herba Centellae, and pulverizing to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into the plant powder obtained in the step (1), extracting, filtering,
in the step (2), the extraction adopts a low-temperature high-pressure difference method, and specifically comprises the following steps: regulating the temperature to be 30-50 ℃, pressurizing to be 50-100MPa, soaking and extracting for 30-60 minutes under stirring, wherein the mass ratio of the plant powder to water, butanediol and 1, 2-pentanediol is 10-30:30-70:30-70:1-10.
2. The acne-removing composition according to claim 1, wherein the composition comprises the raw materials of scutellaria root, cortex phellodendri, coptis root and centella asiatica in a mass ratio of 5:3:3:6.
3. The method for preparing the acne-removing composition according to any one of claims 1 to 2, comprising the steps of:
(1) Drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, and herba Centellae, and pulverizing to obtain plant powder;
(2) Adding water, butanediol and 1, 2-pentanediol into the plant powder obtained in the step (1), extracting, filtering,
in the step (2), the extraction adopts a low-temperature high-pressure difference method, and specifically comprises the following steps: regulating the temperature to be 30-50 ℃, pressurizing to be 50-100MPa, soaking and extracting for 30-60 minutes under stirring, wherein the mass ratio of the plant powder to water, butanediol and 1, 2-pentanediol is 10-30:30-70:30-70:1-10.
4. The method according to claim 3, wherein in the step (2), the mass ratio of the plant powder to water, butanediol, and 1, 2-pentanediol is 17:50:50:5.
5. Use of an anti-acne composition according to any one of claims 1-2 or prepared according to the preparation method of any one of claims 3-4 for the preparation of an anti-acne cosmetic.
6. The use according to claim 5, characterized in that the acne-removing composition is present in the cosmetic in an amount of 2-10wt%.
7. An oil-controlling acne-removing gel characterized by comprising the acne-removing composition according to any one of claims 1 to 2 or the acne-removing composition prepared by the preparation method according to any one of claims 3 to 4.
8. The oil-controlling anti-acne gel according to claim 7, comprising a phase a and a phase B, wherein the phase a comprises water, allantoin, disodium EDTA, polyacrylate crosslinked polymer-6, 1, 2-pentanediol, menthol and the anti-acne composition of any one of claims 1-2 or the anti-acne composition prepared according to the preparation method of any one of claims 3-4; the phase B comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, cyclopentadimethicone, cyclohexasiloxane and dimethicone.
9. The oil control acne-removing gel according to claim 8, wherein the oil control acne-removing gel comprises the following components:
the water is supplemented to 100 wt%
Allantoin 0.2 wt%
EDTA disodium 0.05 wt%
Polyacrylate crosslinked Polymer-6.5 wt%
1, 2-pentanediol 4 wt%
Menthol 0.1 wt%
An anti-acne composition according to any one of claims 1 to 2 or an anti-acne composition prepared according to the method of any one of claims 3 to 4, 2 to 10wt%
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 1 wt%
Cyclopentadimethicone, cyclohexasiloxane 1.5. 1.5 wt%
Polydimethylsiloxane 2.5. 2.5 wt%.
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| CN115025024B (en) * | 2022-07-29 | 2023-11-03 | 维怡美生物科技(广州)有限公司 | Acne and mark removing composition and application thereof |
| CN115414295B (en) * | 2022-09-13 | 2024-03-08 | 中华全国供销合作总社南京野生植物综合利用研究所 | Compound plant acne-removing mite-inhibiting composition and preparation method and application thereof |
| CN116850116A (en) * | 2023-08-24 | 2023-10-10 | 广州唯我美日用品有限公司 | Acne-removing composition, acne-removing facial cleanser containing acne-removing composition and preparation method of acne-removing facial cleanser |
| CN118236308A (en) * | 2024-02-26 | 2024-06-25 | 广州市赛迪药业科技有限公司 | Herbal acne-removing composition and preparation method and application thereof |
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