CN113750015A - Acne removing composition with acne mark removing and scar removing effects and preparation method thereof - Google Patents
Acne removing composition with acne mark removing and scar removing effects and preparation method thereof Download PDFInfo
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- CN113750015A CN113750015A CN202111221741.9A CN202111221741A CN113750015A CN 113750015 A CN113750015 A CN 113750015A CN 202111221741 A CN202111221741 A CN 202111221741A CN 113750015 A CN113750015 A CN 113750015A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention discloses an acne removing composition with acne mark removing and scar removing effects, and relates to the technical field of skin care products. The composition comprises Scutellariae radix extract, cortex Phellodendri extract, Coptidis rhizoma root extract and herba Centellae extract. The preparation method comprises the following steps: (1) drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, and herba Centellae, and pulverizing to obtain plant powder; (2) adding water, butanediol and 1, 2-pentanediol into the plant powder obtained in the step (1), extracting and filtering. The composition has effects of removing acne mark, removing acne scar, controlling oil and removing acne. The function purposes, the function routes and the function mechanisms of each component in the composition are different, and the components show the optimal synergistic effect when in proper dosage proportion. The preparation method can improve the active components of the extract and improve the effect.
Description
Technical Field
The invention relates to the technical field of skin care products, and particularly relates to an acne removing composition with acne mark removing and scar removing effects.
Background
Acne is also called "comedo" and "face blister" in medicine, commonly known as "whelk" and "pimple", and is a very common chronic inflammation of sebaceous glands and hair follicles. It is good at the facial surfaces of young men and women, especially at the forehead, cheeks and chin, and also at the parts with abundant sebaceous glands such as chest, shoulder and back. Under normal conditions, the sebaceous glands secrete a proper amount of grease, and the grease reaches the surface of the skin to achieve the effect of moistening the skin. When skin sebaceous glands are stimulated by stimulation factors (androgen, spicy greasy food, menstruation, mental stress and the like), excessive sebum is secreted, horny layers fall out and are disordered, skin metabolism disorder is caused, old waste horny substances are accumulated, sebum cannot be smoothly discharged, the phenomenon of hair follicle blockage and the like is caused, a closed environment is caused after a hair follicle opening is blocked, acne can be formed, an anoxic state appears in the hair follicle, a growth environment is created for anaerobic propionibacterium acnes, the propionibacterium acnes starts to excessively reproduce, inflammatory substances are gathered by metabolic products of the propionibacterium acnes, inflammatory acne can be formed, pigmentation caused by inflammation often leaves marks on the skin after the acne is eliminated, and the inflammatory reaction of skin cells causes damage to skin tissues at the same time, so that scars are generated. Acne is not only a body disease, but also a body and mind disease which cannot be ignored, and the generation of acne, acne marks and acne scars can cause certain influence on social, psychological, emotional and other aspects of patients. Many products for removing acne sold in the market mainly treat acne marks and acne scars after the acne is removed, but the products cannot well remove or relieve the acne marks and the acne scars generated after the acne is removed, so that the market urgently needs a product with the effects of removing the acne marks and the acne scars, and the multi-effect requirement of the acne removing product is met.
Chinese patent application CN201910615975.8 discloses a composition for whitening, removing freckles, removing acnes and improving skin, which is prepared by mixing a component A, a component B, a component C, a component D, a component E, a component F, a component G and a component H; the component A consists of the following components: deionized water, p-hydroxyacetophenone, a purslane extract and allantoin; the component B consists of the following components: methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, petrolatum and caprylic/capric triglyceride; the component C is an acryloyl dimethyl ammonium taurate/VP copolymer; the component D consists of the following components: deionized water, pearl powder and radix Sophorae Flavescentis powder; the component E consists of the following components: yeast fermentation lysate filtrate, erythritol, butylene glycol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, camellia sinensis extract, glycyrrhiza glabra root extract, chamomile flower extract, rosemary leaf extract, 1, 2-pentanediol, glyceryl caprylate, caprylhydroxamic acid, propylene glycol, hydrolyzed elastin, oat beta-glucan, oat kernel extract, coptis chinensis extract, salvia miltiorrhiza root extract, atractylis lancea extract, dandelion extract, poria cocos extract, coix seed extract, hydroxyphenylpropionamide benzoic acid, glycolic acid, PEG-60 hydrogenated castor oil, ethylhexyl glycerol, glyceryl caprylate, lactobacillus/pear juice fermentation product filtrate, phellodendron bark extract, willow bark extract, rehmannia glutinosa root extract, melia indica folium extract, scutellaria baicalensis root extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea leaf extract, glycyrrhiza glabra extract, salvia miltiorrhiza extract, glycyrrhiza uralensis extract, glycyrrhiza glabra extract, glycyrrhiza uralensis extract, and water, Houttuynia cordata extract, soyabean seed extract, dandelion extract, fructus cnidii extract, radix puerariae extract, angelica sinensis root extract, phellodendron amurense extract, sophora flavescens root extract, fructus kochiae extract, zanthoxylum bungeanum fruit extract, ginseng root extract, arginine ferulate, 1-methylhydantoin-2-imide, dogwood extract, menthol lactate, menthol, lavender oil, borneol, bighead atractylodes rhizome root powder, bletilla striata root powder, Japanese ampelopsis root powder, peony root powder, poria cocos powder and stiff silkworm extract; dandelion extract, fructus cnidii extract, radix puerariae extract, angelica root extract, phellodendron amurense extract, sophora flavescens root extract, fructus kochiae extract, zanthoxylum bungeanum fruit extract, ginseng root extract, arginine ferulate, 1-methylhydantoin-2-imide, dogwood extract, menthol lactate, menthol, lavender oil, borneol, atractylodes macrocephala root powder, bletilla striata root powder, ampelopsis japonica root powder, peony root powder, poria cocos powder and stiff silkworm extract; the component F consists of the following components: deionized water and citric acid; the component G consists of the following components: deionized water and denatonium benzoate; the component H is an acryloyl dimethyl ammonium taurate/VP copolymer.
Chinese patent application CN201911177274.7 discloses an acne removing liquid, which comprises the following raw materials in parts by weight: 10 parts of radix curcumae, 30 parts of herba lycopi, 30 parts of chrysanthemum, 30 parts of poria cocos, 30 parts of periostracum cicadae, 30 parts of cortex moutan, 30 parts of radix paeoniae rubra, 30 parts of coptis chinensis, 30 parts of mallotus japonicus, 30 parts of radix scutellariae, 30 parts of honeysuckle, 30 parts of safflower carthamus, 30 parts of rhizoma atractylodis macrocephalae, 30 parts of rhizoma atractylodis, 30 parts of pearl powder, 30 parts of rose, 30 parts of rhizoma smilacis glabrae, 30 parts of eupatorium fortunei, 30 parts of ginseng, 30 parts of angelica sinensis, 30 parts of peach gum, 10 parts of ganoderma lucidum, 10 parts of borneol, 0.5 part of musk, 45 parts of momordica charantia, 200 parts of herba centellae extract and 200 parts of radix sophorae flavescentis extract.
At present, the acne-removing composition in the prior art has more and more active ingredients which are mixed and are easy to cause adverse reactions, and the preparation or extraction is carried out by adopting a conventional method, so that a great amount of active ingredients are lost. In view of the above, the present application provides a composition having effects of removing acne marks and scarsAcne removing deviceThe composition has simple components, the preparation method can quickly dissolve the effective components in the solvent, and the extract has higher active components and better effect.
Disclosure of Invention
The invention aims to provide an acne-removing composition which has the effects of removing acne marks, removing acne scars, controlling oil and removing acnes. The function purposes, the function routes and the function mechanisms of each component in the composition are different, and the components show the optimal synergistic effect when in proper dosage proportion. The preparation method can improve the active components of the extract and improve the effect.
In order to achieve the purpose, the technical scheme of the invention is as follows:
in one aspect, the invention provides an acne-removing composition with acne mark-removing and scar-removing effects, which comprises a scutellaria baicalensis root extract, a phellodendron amurense bark extract, a coptis chinensis root extract and a centella asiatica extract.
Preferably, the acne-removing composition is prepared from 1-10:1-10:1-10:1-10 by mass of radix scutellariae, cortex phellodendri bark, rhizoma coptidis and centella asiatica; further preferred are scutellaria root, phellodendron bark, coptis root and centella asiatica in a mass ratio of 5:3:3: 6.
"centella asiatica" refers to the whole plant of centella asiatica.
The baicalein, baicalin and other components contained in the scutellaria baicalensis roots influence the metabolism of arachidonic acid through various links, and inhibit the generation of prostaglandin E (PGE) and Leukotriene (LT) to different degrees, thereby relieving the expansion of blood vessels by inflammatory mediators, increasing the permeability of blood vessel walls and chemotactic effect of white blood cells; baicalin also has extremely high inhibitory activity on melanocytes, can remarkably inhibit the generation of lipid peroxide, and can relieve melanin pigmentation;
the phellodendron amurense bark has an anti-inflammatory effect, can directly support the muscle bottom to relieve pockmarks, can promote the generation of collagen to repair scars, combines the oxidation resistance of the collagen, and keeps the skin stable; cortex Phellodendri bark containing berberine, phellodendrine, obacunone, etc. has inhibitory effect on Staphylococcus aureus, Staphylococcus albus, Staphylococcus citricola, Diplococcus pneumoniae, Diplococcus meningitidis, Streptococcus viridis, Vibrio cholerae, Bacillus diphtheriae, Bacillus dysenteriae, Pseudomonas aeruginosa, etc.
The rhizoma coptidis root related by the invention contains various active ingredients such as coptisine and jateorhizine. Has remarkable antibacterial effect on gram-positive bacteria such as staphylococcus aureus, streptococcus pneumoniae, beta lactamase-producing streptococcus pneumoniae and the like, gram-negative bacteria such as pseudomonas aeruginosa, escherichia coli, drug-resistant acinetobacter baumannii, neisseria gonorrhoeae and the like, and fungi such as candida albicans, candida albicans and the like, and can balance grease.
The centella asiatica extract is rich in terpenoids, can obviously improve the content of collagen and cell layer fibronectin (fibronectin is widely involved in the processes of cell migration, adhesion, proliferation, hemostasis, skin tissue repair and the like), and can stimulate and promote the generation of type I and type III collagen, activate fibroblast genes and improve and repair the barrier function of the skin; can promote wound healing and scar repair, and reduce inflammatory reaction. In addition, the centella asiatica extract can reduce the production of proinflammatory mediators (IL-1, MMP-1), and improve and repair the barrier function of the skin.
On the other hand, the invention provides a preparation method of the acne-removing composition, which comprises the following steps:
(1) drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, and herba Centellae, and pulverizing to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into the plant powder obtained in the step (1), extracting and filtering.
Preferably, in the step (1), the pulverization is to 10-50 mesh.
Preferably, in the step (2), the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 10-30:30-70:30-70:1-10, and is further preferably 17:50:50: 5.
Preferably, in the step (2), the extraction is performed by a low-temperature high-pressure difference method, and specifically comprises the following steps: regulating temperature to 30-50 deg.C, pressurizing to 50-100MPa, and soaking and extracting under stirring for 30-60 min.
The low-temperature high-pressure difference method is characterized in that loss of thermosensitive components can be avoided under low-temperature conditions, the solvent can more easily permeate into the plant powder under high-pressure conditions, effective components can be rapidly dissolved in the solvent, and tests prove that the extract obtained by the low-temperature high-pressure difference method has higher active components and better effect.
In another aspect, the invention also provides application of the acne-removing composition in cosmetics.
Preferably, in the application, the content of the acne-removing composition in the cosmetics is 2-10 wt%.
Finally, the invention provides oil-control acne-removing gel which comprises the composition.
Preferably, the oil-control acne-removing gel comprises an A phase and a B phase, wherein the A phase comprises water, allantoin, EDTA disodium, polyacrylate cross-linked polymer-6, 1, 2-pentanediol, menthol and the composition; and the phase B comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, cyclopentadimethylsiloxane, cyclohexasiloxane and polydimethylsiloxane.
Further preferably, the oil-control acne-removing gel comprises the following components:
the invention has the beneficial effects that:
(1) the acne-removing composition provided by the invention has the effects of removing acne marks, removing acne scars, controlling oil and removing acnes. The function purposes, the function routes and the function mechanisms of each component in the composition are different, and the components show the optimal synergistic effect when in proper dosage proportion.
(2) The effective components are plant sources, and have no irritation to skin, mild components and safety.
(3) The low-temperature high-pressure difference method is characterized in that loss of thermosensitive components can be avoided under low-temperature conditions, the solvent can more easily permeate into the plant powder under high-pressure conditions, effective components can be rapidly dissolved in the solvent, and tests prove that the extract obtained by the low-temperature high-pressure difference method has higher active components and better effect.
Detailed Description
The present invention will be further explained with reference to specific examples in order to make the technical means, the technical features, the technical objectives and the effects of the present invention easier to understand, but the following examples are only preferred embodiments of the present invention, and not all embodiments of the present invention. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention. In the following examples, unless otherwise specified, all the operations were performed by conventional methods, all the equipments were performed by conventional methods, and the materials of the equipments used in the respective examples were the same. For process parameters or conditions not specifically mentioned, it can be carried out with reference to conventional techniques.
In the following examples, the term "acne removing agent" refers to the composition prepared by the present invention, including scutellaria root extract, phellodendron bark extract, coptis root extract, centella asiatica extract, and is abbreviated as "yellow" because it contains scutellaria root extract, phellodendron bark extract, and coptis root extract.
Example 1
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) drying radix scutellariae, cortex phellodendri bark, rhizoma coptidis root and centella asiatica, wherein the mass ratio of the radix scutellariae, the cortex phellodendri bark, the rhizoma coptidis root and the centella asiatica is 1:10:1: 1; pulverizing to 50 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, putting into extraction kettle, adjusting temperature to 30 deg.C, pressurizing to 50MPa, soaking and extracting under stirring for 60 min, centrifuging, collecting supernatant, and filtering with 1000 mesh filter cloth.
Example 2
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) drying radix scutellariae, cortex phellodendri bark, rhizoma coptidis root and centella asiatica, wherein the mass ratio of the radix scutellariae, the cortex phellodendri bark, the rhizoma coptidis root and the centella asiatica is 10:1:10: 10; pulverizing to 50 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, putting into extraction kettle, adjusting temperature to 50 deg.C, pressurizing to 100MPa, soaking and extracting under stirring for 30min, centrifuging, collecting supernatant, and filtering with 500 mesh filter cloth.
Example 3
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) drying radix scutellariae, cortex phellodendri bark, rhizoma coptidis root and centella asiatica, wherein the mass ratio of the radix scutellariae, the cortex phellodendri bark, the rhizoma coptidis root and the centella asiatica is 5:3:3: 6; pulverizing to 30 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, putting into extraction kettle, adjusting temperature to 40 deg.C, pressurizing to 80MPa, soaking and extracting under stirring for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 1
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) pulverizing radix Scutellariae to 30 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, putting into extraction kettle, adjusting temperature to 40 deg.C, pressurizing to 80MPa, soaking and extracting under stirring for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 2
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) pulverizing cortex Phellodendri bark to 30 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, putting into extraction kettle, adjusting temperature to 40 deg.C, pressurizing to 80MPa, soaking and extracting under stirring for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 3
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) pulverizing rhizoma Coptidis to 30 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, putting into extraction kettle, adjusting temperature to 40 deg.C, pressurizing to 80MPa, soaking and extracting under stirring for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 4
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) pulverizing herba Centellae to 30 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, putting into extraction kettle, adjusting temperature to 40 deg.C, pressurizing to 80MPa, soaking and extracting under stirring for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 5
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) drying the purslane flower/leaf/stem, the amur corktree bark, the coptis root and the centella asiatica, wherein the mass ratio of the purslane flower/leaf/stem, the amur corktree bark, the coptis root and the centella asiatica is 5:3:3: 6; pulverizing to 30 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, putting into extraction kettle, adjusting temperature to 40 deg.C, pressurizing to 80MPa, soaking and extracting under stirring for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 6
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) drying radix scutellariae, cortex phellodendri bark, rhizoma coptidis root and centella asiatica, wherein the mass ratio of the radix scutellariae, the cortex phellodendri bark, the rhizoma coptidis root and the centella asiatica is 5:3:3: 6; pulverizing to 30 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, placing into extraction kettle, stirring, soaking at room temperature (without pressurizing), extracting for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Comparative example 7
A preparation method of a three-yellow acne removing agent comprises the following steps:
(1) drying radix scutellariae, aloe, rhizoma coptidis root and centella asiatica, wherein the mass ratio of the radix scutellariae, the aloe, the rhizoma coptidis root and the centella asiatica is 5:3:3: 6; pulverizing to 30 mesh to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into plant powder, wherein the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5; mixing, placing into extraction kettle, stirring, soaking at room temperature (without pressurizing), extracting for 40 min, centrifuging, collecting supernatant, and filtering with 800 mesh filter cloth.
Test example 1 anti-Propionibacterium acnes Effect
Propionibacterium acnes is the primary pathogen that causes acne. In the antibacterial experiment, propionibacterium acnes is used as a bacterial model, and in order to verify the antibacterial effect of the composition, the compositions in the embodiments 1 to 3 and the comparative examples 1 to 7 of the invention are subjected to antibacterial performance measurement by referring to GB15979-2002 (hygienic Standard for Disposable sanitary articles) appendix C4 'test method for antibacterial performance of dissolution antibacterial (inhibiting) products':
1) test samples: the compositions described in examples 1-3 and comparative examples 1-7 were diluted to 2% dilutions, respectively.
2) Preparation of bacterial suspension: a24-hour culture of the propionibacterium acnes is washed by 0.03mol/L phosphate buffer solution to prepare 104-106CFU/mL bacterial suspension.
3) Respectively taking 1g of test sample, adding 0.1mL of the bacterial suspension, uniformly coating and mixing, starting timing, adding 9mL of 0.03mol/L phosphate buffer solution after 20min, fully and uniformly mixing, taking 3 dilutions, respectively taking 1mL of the dilutions, placing the dilutions in two parallel plates, adding corresponding culture medium, and culturing for 24 hours at 36 +/-1 ℃ under anaerobic condition to count bacterial colonies. The above experiment was repeated 3 times, and the average was taken and a blank control group was set.
The calculation formula of the bacteriostatic rate is as follows: and X is (A-B)/A X100%, wherein X is the bacteriostasis rate, A is the average recovered colony of a blank control sample, and B is the average recovered colony of a test sample.
The evaluation criteria for efficacy were: (1) the effect is obvious when the bacteriostasis rate is more than or equal to 90 percent; (2) the bacteriostatic rate is 40-90% and the effect is normal; (3) the bacteriostasis rate is less than 40 percent, which indicates no effect. The results are shown in the following table.
TABLE 1 antibacterial (Propionibacterium acnes) test results
| Group of | Propionibacterium acnes inhibition rate (%) | Evaluation of efficacy |
| Example 1 | 90 | The effect is obvious |
| Example 2 | 91 | The effect is obvious |
| Example 3 | 94 | The effect is obvious |
| Comparative example 1 | 42 | General effects |
| Comparative example 2 | 48 | General effects |
| Comparative example 3 | 53 | General effects |
| Comparative example 4 | 40 | General effects |
| Comparative example 5 | 42 | General effects |
| Comparative example 6 | 68 | General effects |
| Comparative example 7 | 40 | General effects |
As can be seen from Table 1, the compositions of examples 1 to 3 have an obvious bacteriostatic effect on Propionibacterium acnes, and the compositions of comparative examples 1 to 7 have a general bacteriostatic effect; experiments show that the scutellaria baicalensis roots, the phellodendron amurense barks, the coptis roots and the centella asiatica can obviously inhibit the proliferation of propionibacterium acnes when being used in a combined way according to a proper proportion, and the inhibition effect is better than that when the components are used independently; can effectively prevent or improve the acne symptom of the skin.
Example 4
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 2.
Example 5
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 3.
Example 6
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 4.
Comparative example 8
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 5.
Comparative example 9
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 6.
Comparative example 10
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 7.
Comparative example 11
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 8.
Comparative example 12
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 9.
Comparative example 13
The oil-control acne-removing gel comprises the following components in percentage by mass:
table 10.
Test example 2 oil control acne removal test
The oil-controlling and acne-removing efficacy of the oil-controlling and acne-removing condensation prepared in examples 4-6, comparative examples 8-13 and blank control group was evaluated. The blank control group was different from example 6 in that it did not contain the acne removing agent.
The oil control effect tester is a skin oil tester. The working principle of the skin cuticle oil absorption rubber belt is that a special rubber belt is adopted, oil on the surface of the skin cuticle can be absorbed quickly, the transmittance of the rubber belt can be changed by the oil, and the oil content of the skin cuticle can be obtained by measuring the transmittance of the rubber belt before and after use through a photometer arranged in an instrument.
The test method comprises the following steps: 100 volunteers with oily skin and whelk are recruited and divided into 10 groups of 10 persons each, wherein one group uses the oil-controlling and acne-removing gel of a blank control group, three groups use the oil-controlling and acne-removing gels prepared in examples 4-6 respectively, and six groups use the oil-controlling and acne-removing gels prepared in comparative examples 8-13 respectively, and the oil-controlling and acne-removing gels are used once in the morning and evening every day with the use amount of 0.2 g/time, smeared on the face and lightly massaged until being absorbed. The oil content of the forehead of the volunteer was measured every other week with a skin oil tester, each part was tested 3 times, the average was taken, and the specific test record is shown in table 2. The acne removing condition is recorded by taking pictures every other week, the acne number is reduced by more than 1/3 and the judgment is effective by comparing the picture with the picture before using the product, and the specific test records are shown in the table.
TABLE 11 oil control test recording table
TABLE 12 acne-removing test record sheet
As can be seen from tables 11 and 12, the oil-controlling acne-removing gel prepared by the embodiment of the invention has good oil-controlling acne-removing effect; and the combination of the radix scutellariae, the bark of amur corktree, the root of coptis and the centella asiatica according to a proper proportion has better acne removing effect than that of single use.
Comparative example 14
The acne-removing conditioning essence (containing salicylic acid) with better public praise is selected
Comparative example 15
Centella asiatica acne-removing cream with good public praise
Test example 3 acne mark and scar removal test
The oil-controlling and acne-removing gel prepared in examples 4-6 and comparative examples 8-13, the oil-controlling and acne-removing gel prepared in a blank control group and the commercial acne-removing products prepared in comparative examples 14-15 were evaluated for the efficacy of removing acne marks and scars, wherein the blank control group is different from the example 6 in that no acne removing agent is contained.
The test method comprises the following steps: 120 volunteers with newly generated acne marks and scars (generated within one month) are gathered and divided into 10 groups, 10 persons are gathered, one group of the groups uses the oil-control acne-removing gel of a blank control group, three groups of the groups use the oil-control acne-removing gel prepared in examples 4-6 respectively, six groups of the groups use the oil-control acne-removing gel prepared in comparative examples 8-13 respectively, two groups of the groups use the commercially available acne-removing products of comparative examples 14-15 respectively, and the groups are used once a day in the morning and evening with the use amount of 0.2 g/time, smeared on the face and gently massaged until the gel is absorbed. The conditions of the acne marks and the acne scars after the volunteers use the product for one month are compared, and specific test records are shown in the table.
TABLE 13 acne mark removing test record sheet
TABLE 14 acne scar test recording sheet
From 13 and 14, the acne mark removing and conditioning essence (containing salicylic acid) of the comparative example 14 has a good acne mark removing effect and a poor acne scar removing effect; the centella asiatica acne cream of the comparative example 15 has good scar removing effect and poor acne mark removing effect; the oil-control acne-removing gel prepared by the embodiment of the invention has good acne mark-removing and scar-removing effects, and has better acne-removing effect than that of each component used independently.
Test example 4 irritation test (Patch test)
Test samples: oil-controlling acne-removing gel prepared in examples 4-6 and commercially available acne-removing products of comparative examples 14-15.
Subject: selecting 30 volunteers (the same batch of subjects is used for each test sample);
the test method comprises the following steps: a closed test is adopted, 0.02g of test sample is placed in a patch applicator, a hypoallergenic adhesive tape is applied to the arm curve side of a tested subject, the test area is at least 5 x 5cm, the tested subject straightens the arm when applying, the test sample is applied from the lower part to the upper part, the adhesive tape is lightly pressed by the palm to discharge air, the test sample is tightly attached to the skin for 24 hours, and the blank control group is a test sample which is not used.
And (4) observing results: the patch was removed 30min and then interpreted according to the interpretation criteria described below, and the statistical test results are shown in the table below.
Interpretation criteria: (one) negative reaction; (+ -suspicious reaction: only mild erythema; (+) weak positive: erythema, infiltrates, and possibly small amounts of papules; strong positive (++): erythema, infiltrates, papules, blisters; (+++) very positive: erythema, infiltrates, papules, blisters, bulla.
TABLE 15 irritation test records
| Test item | Negative/rate | Suspected reaction/rate | Weak positive/rate | Strong positive/rate | Very strong positive/rate | Positive rate |
| Example 4 | 30/100％ | 0/0 | 0/0 | 0/0 | 0/0 | 0 |
| Example 5 | 30/100％ | 0/0 | 0/0 | 0/0 | 0/0 | 0 |
| Example 6 | 30/100％ | 0/0 | 0/0 | 0/0 | 0/0 | 0 |
| Comparative example 14 | 16/53.33％ | 12/40％ | 2/6.67％ | 0/0 | 0/0 | 46.67％ |
| Comparative example 15 | 28/93.33％ | 2/6.67％ | 0/0 | 0/0 | 0/0 | 6.67％ |
As can be seen from the table above, the oil-controlling and acne-removing condensation prepared in the embodiments 4-6 of the invention has low skin sensitization, and no positive reaction is detected in 30 subjects, which indicates that the composition has no stimulation to skin, mild components and safety.
In conclusion, compared with the comparative examples, the three-yellow acne removing agent composition obtained in examples 1-3 has more remarkable effects of reducing skin grease secretion and better acne removing effect, and especially, the effect of example 3 is the most ideal; the experimental result shows that the composition can embody the best oil-controlling and acne-removing efficacy by matching and combining the components in a proper proportion, and has the best acne mark-removing and scar-removing efficacy. The analysis proves that the efficacy of the composition is due to the fact that the action purposes, the action routes and the mechanisms of all the components in the composition are different, and the components show the best synergistic effect when being used in the right dosage proportion; and tests prove that the composition has no stimulation to skin, mild components and safety.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. An acne-removing composition with the effects of removing acne marks and acne scars is characterized by comprising a scutellaria baicalensis root extract, a phellodendron amurense bark extract, a coptis chinensis root extract and a centella asiatica extract.
2. The acne-removing composition according to claim 1, wherein the raw materials of the composition are scutellaria baicalensis root, phellodendron amurense bark, coptis chinensis root and centella asiatica in a mass ratio of 1-10:1-10: 1-10.
3. The acne treatment composition according to claim 2, wherein the raw materials of the composition are scutellaria baicalensis root, phellodendron amurense bark, coptis chinensis root and centella asiatica in a mass ratio of 5:3:3: 6.
4. A method for preparing the acne-removing composition according to any one of claims 1 to 3, which comprises the following steps:
(1) drying radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, and herba Centellae, and pulverizing to obtain plant powder;
(2) adding water, butanediol and 1, 2-pentanediol into the plant powder obtained in the step (1), extracting and filtering.
5. The preparation method according to claim 4, wherein in the step (2), the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 10-30:30-70:30-70: 1-10.
6. The preparation method according to claim 5, wherein in the step (2), the mass ratio of the plant powder to the water, the butanediol and the 1, 2-pentanediol is 17:50:50: 5.
7. The preparation method according to claim 4, wherein in the step (2), the extraction is performed by a low-temperature high-pressure difference method, and specifically comprises the following steps: regulating temperature to 30-50 deg.C, pressurizing to 50-100MPa, and soaking and extracting under stirring for 30-60 min.
8. Use of the acne-removing composition according to any one of claims 1 to 3 or the acne-removing composition prepared by the preparation method according to any one of claims 4 to 7 in cosmetics; preferably, in the application, the content of the acne-removing composition in the cosmetic is 2-10 wt%.
9. An oil-controlling acne-removing gel, which is characterized by comprising the acne-removing composition as described in any one of claims 1 to 3 or prepared by the preparation method as described in any one of claims 4 to 7.
10. The oil-controlling acne-removing gel according to claim 9, characterized by comprising phase a and phase B, wherein phase a comprises water, allantoin, disodium EDTA, polyacrylate crosspolymer-6, 1, 2-pentanediol, menthol and the acne-removing composition; the phase B comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, cyclopentadimethylsiloxane, cyclohexasiloxane and polydimethylsiloxane;
preferably, the oil-control acne-removing gel comprises the following components:
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