CN106974858A - A kind of acne-removing composition of Sage Extract and its application - Google Patents
A kind of acne-removing composition of Sage Extract and its application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a kind of acne-removing composition of Sage Extract and its application, composition is made up of Atractylis chinensis rhizome extract, papaya extractives and biennial wormwood extract, good antimicrobial effect of the inhibiting bacteria and diminishing inflammation effect than single component of complex composition, synergy has significant antibacterial effect；Composition can nutrition skin, with reference to NMF, the water conservation water lock ability of system is strengthened, so as to reach certain moisture-keeping function and promote the reparation of impaired skin.Composition is applied in anti-acne essence, can be quickly absorbed by the skin, and plays its maximum anti-acne effect；By improving the wettability of skin, suppressing skin ester excessive secretion, regulation skin oil and fat balance, antibacterial anti-inflammatory, the approach for going acne print, the effect of full effect anti-acne is reached.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of acne-removing composition of Sage Extract and its application.
Background technology
Acne, is commonly called as " whelk ", to betide the chronic inflammatory skin of pilosebaceous follicle.Occur mainly in sebum
The position that gland is densely distributed, smegma is vigorous.At present, the pathogenesis for whelk has had certain understanding, loses
Biography, endocrinopathy, poor environment stimulate and pressure it is excessive be long acne major incentive.For pathogenesis, it can select
Plant anti-acne composition, is prepared into product for resolving poxes, to meet demand of the people to " green cosmetics ".
Application of the active components of plants in cosmetics is more and more extensive, application liquid of the plant extracts in product for resolving poxes
It is more and more.Chinese patent CN10358062A is disclosed using chrysanthemum, watermelon peel freeze-dried powder, the Radix Astragali, cucumber extract, rose
Pox-eliminating whitening liquid prepared by the compositions such as essential oil, tea oil, lemon oil；Chinese patent CN103041113A disclose using kuh-seng,
The plant components such as the root bark of tree peony, aloe, radix scutellariae, radix glycyrrhizae, prepare a kind of gel for treating acne.The patent of such patent product for resolving poxes is
Through a lot, but generally existing works slow, and treatment cycle is long, and preparation technology is complicated, the problems such as cost is big.
Also have on the market and much declare products such as " anti-acne " " removing acne " " anti-acnes ", but much there is propaganda or exaggerate a surname
The problems such as biography, i.e. product, do not have anti-acne effect or anti-acne effect unobvious；Or violated anti-acne raw material is added, cause product
Security is low；Or regulated substance is exceeded, it is used for a long time, makes skin loadings excessive, cause the skin of unrepairable to damage.Cause
This, researches and develops the significant product for resolving poxes of a natural gentle, safe, effect, is one of the emphasis of cosmetics research and development.
The content of the invention
In view of the above-mentioned problems, it is an object of the invention to provide a kind of acne-removing composition for integrating treatment and skin care,
And apply composition in anti-acne essence, energy active balance grease reaches the anti-acne effect perfected.
To reach above-mentioned purpose, the present invention provides following scheme：
A kind of acne-removing composition of Sage Extract includes following component：Atractylis chinensis rhizome extract, papaya extractives, argy wormwood
Extract, wherein, Atractylis chinensis rhizome extract, papaya extractives, the weight part ratio of biennial wormwood extract are (2-10) in composition:
(1-9):(3-8)。
The preparation method of the Atractylis chinensis rhizome extract is：Dry Atractylis chinensis rhizome is crushed；Use 75%-85% second
Alcohol circumfluence distillation, 50-75 DEG C of Extracting temperature merges extract solution, is concentrated into no alcohol taste and obtains concentrate；To the above-mentioned concentration of step
Liquid extracting n-butyl alcohol, obtains n-butyl alcohol extract；By n-butyl alcohol extract AB-8 type macroporous resin enrichments, distilled water is first used
Elution, then 60% ethanol elution is used, 60% ethanol eluate is collected, is concentrated under reduced pressure, is spray-dried, obtains the Atractylis chinensis rhizome
Extract.
The preparation method of the papaya extractives is：Papaya tablet is decocted 2-3 times with vapor heating, it is each 1-2 hours；
Filter to get filtrate, 70-85% ethanol precipitations will be used after filtrate heating concentration；The alcohol clear liquid heating concentration of acquisition obtains medicinal extract shape wood
Melon extract.
The preparation method of the biennial wormwood extract is：Dry mugwort leaf is crushed, solid material is obtained；By solid material plus
Enter deionized water soaked overnight, solid-to-liquid ratio (g/ml) is 1:15-1:20；Take above-mentioned heating and refluxing extraction 2-3 times, extraction time is
1-3h, 60-75 DEG C of Extracting temperature；Merging filtrate；Filtrate is filtered to remove impurity；Filtrate decompression is concentrated and dried to obtain dried object；Will
Dried object, which was crushed, obtains the biennial wormwood extract after 65-80 mesh sieves.
The present invention also provides application of the acne-removing composition of energy Sage Extract in cosmetics are prepared, and the cosmetics
For Essence.
The Essence is consisted of the following composition：25-30 parts of 0.2-3 parts of acne-removing composition, the NMF of Sage Extract, chela
0.05-0.1 parts of mixture, 0.1-0.3 parts of preservative, deionized water add to 100 parts.
The NMF be 1,3 butylene glycol, Sodium Hyaluronate, DPG, glycerine, propane diols, butanediol at least
It is a kind of；The chelating agent is at least one of EDETATE SODIUM, Etidronic Acid；The preservative is methyl hydroxybenzoate, oxybenzene third
At least one of ester, Phenoxyethanol.
The present invention also provides a kind of preparation method of Essence, comprises the following steps：By NMF, chelating agent, deionization
Water mixing, which is heated to 70-80 DEG C, is completely dissolved it；It is cooled to after 45 DEG C, sequentially adds the anti-acne of described Sage Extract
Composition, preservative, stir, low temperature discharging.
Following introduce is made to the plant component of the present invention：
Atractylis chinensis is the dry rhizome of feverfew Atractylis chinensis, and nature and flavor are pungent.Pharmaceutical research shows that Atractylis chinensis rhizome is extracted
Thing has the effect such as antiulcer, diuresis, liver protection, anti-inflammatory, antibacterial.The principal component of its volatile oil is the eudesmols of β mono- or the folium eucalyptis of β mono-
Oleyl alcohol and atractylone.Involatile constituent also containing the water soluble ingredient such as amino acid, polyacetylene platform thing, sequiterpene glucosides and
A small amount of furfural, has obvious sterilization functions to tulase, staphylococcus aureus, Escherichia coli, dead leaf bacillus and Pseudomonas aeruginosa.
Pawpaw is the dry mature fruit of rosaceous plant chaenomeles lagenaria.Contain carpaine, pawpaw in papaya extractives
Protease, chymopapain, lycopene, vitamin B, C, E, sugar, protein, carrotene, kryptoxanthin etc..With certain U.S.
In vain, the effect of skin is repaired in nutrition.In addition, composition (such as oleanolic acid, pomolic acid and black bearberry containing Antithemolytic streptococcus
Alcohol) and suppress streptolysin sitosterol, pomolic acid, oleanolic acid have anti-inflammatory, it is antibacterial, reduction transaminase, wide spectrum resist
Bacterium acts on.
Argy wormwood is a kind of composite family herbaceos perennial.The smell of argy wormwood has the calm effect set the mind at rest, relax body and mind.
Biennial wormwood extract main component has 1,8- cineoles, α-keep ketone, acetylcholine, choline etc., and they have anti-inflammation, antiallergy
With the effect stimulated circulation.
Compared with prior art, the device have the advantages that as follows：
(1) Atractylis chinensis rhizome extract, papaya extractives and the argy wormwood that the present invention will there is excellent inhibiting bacteria and diminishing inflammation to act on
Extract is compounded, good antimicrobial effect of the inhibiting bacteria and diminishing inflammation effect than single component of complex composition, synergy, there is significant suppression
The effect of bacterium；(2) composition of the invention can nutrition skin, with reference to NMF, strengthen the water conservation water lock ability of system so that
Reach certain moisture-keeping function and promote the reparation of impaired skin；(3) anti-acne essence of the invention, quickly can be inhaled by skin
Receive, play its maximum anti-acne effect；Put down by improving the wettability of skin, suppressing skin ester excessive secretion, regulation skin oil and fat
Weighing apparatus, antibacterial anti-inflammatory, the approach for going acne print, reach the effect of full effect anti-acne；(4) pH of anti-acne essence of the invention is weak acid
Property, do not stimulate gently, safe, collection treatment and maintenance one can prevent or treat acne；And the preparation work of anti-acne essence
Skill is simple, is produced on a large scale.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The acne-removing composition of Sage Extract：2 parts of Atractylis chinensis rhizome extract, 1 part of papaya extractives, 3 parts of biennial wormwood extract,
Portion is set to 100g；Atractylis chinensis rhizome extract 200g, papaya extractives 100g, biennial wormwood extract 300g；Atractylis chinensis rhizome is carried
It is 2 to take thing, papaya extractives, the mass ratio of biennial wormwood extract:1:3.
The preparation method of Atractylis chinensis rhizome extract is：Dry Atractylis chinensis rhizome is crushed；Carried with 75 alcohol heat reflux
Take, 50 DEG C of Extracting temperature, merge extract solution, be concentrated into no alcohol taste and obtain concentrate；The above-mentioned concentrate of step is extracted with n-butanol
Take, obtain n-butyl alcohol extract；By n-butyl alcohol extract AB-8 type macroporous resin enrichments, first with distillation water elution, then use
60% ethanol elution, collects 60% ethanol eluate, is concentrated under reduced pressure, and is spray-dried, obtains the Atractylis chinensis rhizome extract.
The preparation method of papaya extractives is：Papaya tablet is decocted 3 times, every time 2 hours with vapor heating；Filtering to filter
Liquid, will use 85% ethanol precipitation after filtrate heating concentration；The alcohol clear liquid heating concentration of acquisition obtains medicinal extract shape papaya extractives.
The preparation method of biennial wormwood extract is：Dry mugwort leaf is crushed, solid material is obtained；Solid material is added and gone
Ionized water soaked overnight, solid-to-liquid ratio (g/ml) is 1:15-1:20；Take above-mentioned heating and refluxing extraction 2 times, extraction time is 1h, is carried
Take temperature 60 C；Merging filtrate；Filtrate is filtered to remove impurity；Filtrate decompression is concentrated and dried to obtain dried object；Dried object is crushed
Cross and the biennial wormwood extract is obtained after 65-80 mesh sieves.
Embodiment 2
The acne-removing composition of Sage Extract：10 parts of Atractylis chinensis rhizome extract, 9 parts of papaya extractives, biennial wormwood extract 8
Part, portion is set to 10g；Atractylis chinensis rhizome extract 100g, papaya extractives 90g, biennial wormwood extract 80g；Atractylis chinensis rhizome is carried
It is 10 to take thing, papaya extractives, the mass ratio of biennial wormwood extract:9:8.
The preparation method of Atractylis chinensis rhizome extract is：Dry Atractylis chinensis rhizome is crushed；Use 85% alcohol heat reflux
Extract, 75 DEG C of Extracting temperature, merge extract solution, be concentrated into no alcohol taste and obtain concentrate；To the above-mentioned concentrate n-butanol of step
Extraction, obtains n-butyl alcohol extract；By n-butyl alcohol extract AB-8 type macroporous resin enrichments, first with distillation water elution, then use
60% ethanol elution, collects 60% ethanol eluate, is concentrated under reduced pressure, and is spray-dried, obtains the Atractylis chinensis rhizome extract.
The preparation method of papaya extractives is：Papaya tablet is decocted 2 times, every time 1 hour with vapor heating；Filtering to filter
Liquid, will use 70% ethanol precipitation after filtrate heating concentration；The alcohol clear liquid heating concentration of acquisition obtains medicinal extract shape papaya extractives.
The preparation method of biennial wormwood extract is：Dry mugwort leaf is crushed, solid material is obtained；Solid material is added and gone
Ionized water soaked overnight, solid-to-liquid ratio (g/ml) is 1:15-1:20；Take above-mentioned heating and refluxing extraction 2 times, extraction time is 3h, is carried
Take 75 DEG C of temperature；Merging filtrate；Filtrate is filtered to remove impurity；Filtrate decompression is concentrated and dried to obtain dried object；Dried object is crushed
Cross and the biennial wormwood extract is obtained after 65-80 mesh sieves.
Embodiment 3
The acne-removing composition of Sage Extract：1 part of Atractylis chinensis rhizome extract, 1 part of papaya extractives, 1 part of biennial wormwood extract,
Portion is set to 100g；Atractylis chinensis rhizome extract 100g, papaya extractives 100g, biennial wormwood extract 100g；Atractylis chinensis rhizome is carried
It is 1 to take thing, papaya extractives, the mass ratio of biennial wormwood extract:1:1.
The preparation method of Atractylis chinensis rhizome extract is：Dry Atractylis chinensis rhizome is crushed；Use 80% alcohol heat reflux
Extract, 60 DEG C of Extracting temperature, merge extract solution, be concentrated into no alcohol taste and obtain concentrate；To the above-mentioned concentrate n-butanol of step
Extraction, obtains n-butyl alcohol extract；By n-butyl alcohol extract AB-8 type macroporous resin enrichments, first with distillation water elution, then use
60% ethanol elution, collects 60% ethanol eluate, is concentrated under reduced pressure, and is spray-dried, obtains the Atractylis chinensis rhizome extract.
The preparation method of papaya extractives is：Papaya tablet is decocted 3 times, every time 1 hour with vapor heating；Filtering to filter
Liquid, will use 80% ethanol precipitation after filtrate heating concentration；The alcohol clear liquid heating concentration of acquisition obtains medicinal extract shape papaya extractives.
The preparation method of biennial wormwood extract is：Dry mugwort leaf is crushed, solid material is obtained；Solid material is added and gone
Ionized water soaked overnight, solid-to-liquid ratio (g/ml) is 1:15-1:20；Take above-mentioned heating and refluxing extraction 3 times, extraction time is 2h, is carried
Take 75 DEG C of temperature；Merging filtrate；Filtrate is filtered to remove impurity；Filtrate decompression is concentrated and dried to obtain dried object；Dried object is crushed
Cross and the biennial wormwood extract is obtained after 65-80 mesh sieves.
The elite formula of liquid of embodiment 4~8 is shown in Table one, and the acne-removing composition of the Sage Extract described in embodiment 4~8 is implementation
The acne-removing composition of the made Sage Extract of example 1.
Table one
The preparation method of the Essence of embodiment 4~8 comprises the following steps：By 1,3 butylene glycol, Sodium Hyaluronate, dipropyl two
Alcohol, glycerine, propane diols, butanediol, EDETATE SODIUM, Etidronic Acid, deionized water mix and are heated to 70 DEG C and make its complete
Dissolving；It is cooled to after 45 DEG C, acne-removing composition, methyl hydroxybenzoate, Nipasol, the Phenoxyethanol of Sage Extract stir, low
Temperature discharging.
The elite formula of liquid of embodiment 9~13 is shown in Table two, and the acne-removing composition of the Sage Extract described in embodiment 9~13 is real
Apply the acne-removing composition of the made Sage Extract of example 2
Table two
The preparation method of the Essence of embodiment 4~8 comprises the following steps：By 1,3 butylene glycol, Sodium Hyaluronate, dipropyl two
Alcohol, glycerine, propane diols, butanediol, EDETATE SODIUM, Etidronic Acid, deionized water mix and are heated to 75 DEG C and make its complete
Dissolving；It is cooled to after 45 DEG C, acne-removing composition, methyl hydroxybenzoate, Nipasol, the Phenoxyethanol of Sage Extract stir, low
Temperature discharging.
The elite formula of liquid of embodiment 14~18 is shown in Table two, and the acne-removing composition of the Sage Extract described in embodiment 14~18 is
The acne-removing composition of the made Sage Extract of embodiment 3
Table three
The preparation method of the Essence of embodiment 14~18 comprises the following steps：By 1,3 butylene glycol, Sodium Hyaluronate, dipropyl
Glycol, glycerine, propane diols, butanediol, EDETATE SODIUM, Etidronic Acid, deionized water mix and are heated to 80 DEG C and make its complete
Fully dissolved；It is cooled to after 45 DEG C, acne-removing composition, methyl hydroxybenzoate, Nipasol, the Phenoxyethanol of Sage Extract stir,
Low temperature discharges.
Comparative example 1
Difference with embodiment 4 is not add Atractylis chinensis rhizome extract, other preparation conditions and method and the phase of embodiment 1
Together.
Comparative example 2
Difference with embodiment 4 is not add papaya extractives, and other preparation conditions and method are same as Example 1.
Comparative example 3
Difference with embodiment 4 is not add biennial wormwood extract, and other preparation conditions and method are same as Example 1.
Comparative example 4
Difference with embodiment 4 is the acne-removing composition for not adding Sage Extract, other preparation conditions and method and implementation
Example 1 is identical.
Comparative example 5
Difference with embodiment 4 is that the parts by weight of the acne-removing composition of Sage Extract are 3.1, other preparation conditions and side
Method is same as Example 1.
Suppression experiment to propionibacterium acnes
The generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction etc.
Factor is closely related.The level of androgen particularly testosterone in descendant's body that adolesces is raised rapidly, promotes sebaceous glands development
And produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, and dyssebacia forms cutin
Bolt is micro mist thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase that propionibacterium acnes is produced
Sebum generation free fatty is decomposed, while chemotactic inflammatory cell and medium, finally induce and aggravate inflammatory reaction.Thus may be used
See, propionibacterium acnes amount reproduction is a key factor for inducing whelk and causing whelk to deteriorate, therefore, research pair
The inhibitory action of propionibacterium acnes is to evaluate one of important method of sample anti-acne action effect.
(1) test specimen：The acne-removing composition of the Sage Extract of embodiment 1, Atractylis chinensis rhizome extract, papaya extractives,
The composition of biennial wormwood extract, papaya extractives and biennial wormwood extract, 5 groups of propionibacterium acnes bacterial strain is (at patients with acne skin damaged
It is isolated)；
(2) test method：
1. culture, separation, the identification of anaerobic bacteria：THl0 cultures will be inoculated at patients with acne skin damaged by isolated sample
In base, airbag method is used, 37 DEG C of culture 72h in anaerobic jar are placed in, indicator is made with methylene blue, palladium grain is catalysis thorn.
2. the separation of anaerobic bacteria
Picking single bacterium colony, turns 2 pieces of flat boards, one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition；Another piece with
37 DEG C of aerobic cultures；Result is observed after 48h.
3. the identification of anaerobic bacteria
Without bacterial growth under aerobic culture；
Occur the raised circle of homogeneous form, canescence, tiny, diameter about 1.0mm, edge on the flat board of Anaerobic culturel slightly
Neat bacterium colony, visible chromabacterium biolaceum under microscopy, mirror is made by bacterium colony.It is micro-bend in bar-shaped or shaft-like, can one end blunt circle, one end attenuates,
Coloring is not deep, and cell is single, can arrange or arrange in pairs as shapes such as " people ", " v ".Again tested through oxytolerant, catalase test, indoles
Experiment, biochemical serial test for identification are propionibacterium acnes.
4. anaerobism drug sensitive test
Inoculation：1 colony inoculation in the bacterium colony more than picking cultivated is on LB plating mediums, the aerobic trainings of 370C
24h is supported, aerobic culture 24h propionibacterium acneses are rinsed with sterile saline, flushing liquor is put into sterile test tube；Using wheat
Family name's turbidimetry is than turbid, and opacity tube is with shaking 12 times is before needed, first than turbid to 3 × 108/mL, then with normal saline dilution to 106/mL
It is standby.
LB plating mediums are inoculated with：The swab stick of sterilizing is dipped into bacterium solution, unnecessary bacterium solution is gone in being squeezed on tube wall, in the training of LB flat boards
Even spread on base is supported, and a circle is swept along plate edge ring, plate is covered, 2min is dried.Sterile steel bowl (a diameter of 6mm) is light
It is put on plating medium, fills it up with the acne-removing composition of the Sage Extract of the gained of embodiment 1, be put into 37 DEG C of aerobic culture 24h, send out
Without bacterial growth in existing plate, see there is inhibition zone to be formed after continuing 37 DEG C of aerobic culture 24h.Antibacterial circle diameter is surveyed, it is antibacterial by 3 groups
Loop diameter value is averaged.
Result of the test：Acne-removing composition group to add the Sage Extract of embodiment 1 is extracted as experimental group with Atractylis chinensis rhizome
Thing substitution embodiment 1 composition extract is control group 1, replaces the composition extract of embodiment 1 as control using papaya extractives
Group 2, replaces the composition extract of embodiment 1 as control group 3 using biennial wormwood extract, is replaced with papaya extractives and biennial wormwood extract
The composition extract of embodiment 1 is control group 4.Chinese medicine antibacterial susceptibility grade classification, with reference to corresponding antibiotic standard ".Antibacterial ring size
Diameter>20mm is Gao Min, and 10~20mm is quick in being,<10mm is resistance, and specific observation result is as shown in Table 4.
Table four
Efficacy assessments：
From above result of the test can be seen that the present invention Sage Extract acne-removing composition and Atractylis chinensis rhizome extract,
Papaya extractives, biennial wormwood extract, the composition of papaya extractives and biennial wormwood extract, which all have, suppresses propionibacterium acnes
Effect, and the acne-removing composition of Sage Extract has high quick effect (antibacterial circle diameter to propionibacterium acnes>20mm)；Atractylis chinensis
Rhizome extract, papaya extractives, biennial wormwood extract, the composition of papaya extractives and biennial wormwood extract are to propionibacterium acnes
There is quick effect (antibacterial circle diameter is between 10~20mm), it can thus be seen that northern in the acne-removing composition of Sage Extract of the present invention
Rhizoma atractylodis rhizome extract, papaya extractives, biennial wormwood extract have the effect of Synergistic.
Skin Irritation Test
(1) test specimen：The anti-acne essence of embodiment 4；
(2) experimental animal：Small white mouse
(3) 24h shaves off small white mouse back cervical vertebra diamond wool before testing, unhairing scope or so 2cm × 2cm, and side is used for
Experiment, side is used to compare, and skin is cleaned using warm water, then wipes test specimen on a side test skin, wipes daily
Wipe 1 time, 1h observes skin wound repair after wiping, continuous to wipe 7 days.
(4) result of the test：, never there is erythema oedema etc. using the anti-acne essence of embodiment 1 in 7 days Skin Irritation Tests
Etc. stimulate the reaction.
Acne-removing is verified
Subjects：
The 630 26-35 Sui volunteer with whelk, volunteer's facial area has papule, redness, skin greasing, pore
Thick, inflammatory reaction substantially, the warts symptom such as continuous repeatedly.
Selection standard:Glucocorticoid, dimension A classes medicine, antibiotic etc. are taken in clinical observation the last fortnight, and in the observation period
Between without using said medicine；No drinking during observation, excessively pungent stimulation group food is not eaten.
630 people are randomly divided into 21 groups, every group of 30 people correspond to embodiment 4~18 respectively, and the comparative example 6 of comparative example 1~6 is
The excellent commercially available anti-acne essence of anti-acne effect.Patient is sooner or later clean rear by the appropriate mildy wash of offer by Irrigation daily
It is evenly coated on the face and then cleans up, continuing more than 30d must not be interrupted.
Criterion of therapeutical effect：
Criterion of therapeutical effect is worked out with reference to the guideline of clinical investigations that new Chinese medicine treats acne vulgaris.1) it is almost recovered:It is scorching
Property fash all disappear, pigmentation is only stayed, without new fash；2) it is effective:Inflammatory deflorescence more than 70%, new fash is less than 5
It is individual；3) effectively:More than inflammatory deflorescence 30%-60%, new fash is less than 10；4) it is invalid:Inflammatory deflorescence is not enough
29% or without significant change, or even add severe one.
Clinical efficacy result is as shown in Table 5 after 30d：
From table five, the average cure rate of embodiment 4~18 is 96%, significantly larger than comparative example 1~6, it is seen that this hair
The anti-acne essence that the acne-removing composition of bright Sage Extract is made has remarkable result on anti-acne effect；Comparative example 4 and embodiment 1
The acne-removing composition for being distinguished as not adding Sage Extract, as a result almost without anti-acne effect, it is seen that in Sage Extract of the present invention
The made anti-acne essence of acne-removing composition in, the acne-removing composition of Sage Extract is principle active component；Comparative example 1 and reality
Apply example 4 be distinguished as do not add Atractylis chinensis rhizome extract, experimental result fully recover 6 people, effective 9 people, effective 4 people, invalid 12 people
It can be seen that anti-acne effect is substantially poorer than embodiment 4, composition compatibility changes completely, loses synergistic function, and comparative example 2~3 is same
Reason, contrasts visible in the acne-removing composition of Sage Extract of the present invention by comparative example 1~3 and embodiment 4, and Atractylis chinensis rhizome is extracted
Thing, papaya extractives and the biennial wormwood extract Synergistic in terms of anti-acne.
Represent to use after corresponding anti-acne essence using the trier of embodiment 4~18, face is salubriouser, and water is tender
After use as snug as a bug in a rug.
Upper embodiment only illustrates embodiment of the present invention, does not have any formal limitation to the present invention；It is any
Professional and technical personnel is engaged in, all has the ability to make some changes using the technology contents disclosed or modifies, become as equivalent
The equivalent embodiment of change, according to the technology of the present invention essence, simply modification, equivalent variations and modification is carried out to the present invention, is belonged to
In the range of technical solution of the present invention.
Claims (9)
1. a kind of acne-removing composition of Sage Extract, it is characterised in that the composition includes following component：Atractylis chinensis rhizome is carried
Thing, papaya extractives, biennial wormwood extract are taken, wherein, Atractylis chinensis rhizome extract, papaya extractives, argy wormwood are extracted in composition
The weight part ratio of thing is (2-10):(1-9):(3-8).
2. the acne-removing composition of a kind of Sage Extract according to claim 1, it is characterised in that the Atractylis chinensis rhizome is carried
The preparation method for taking thing is：Dry Atractylis chinensis rhizome is crushed；Extracted with 75%-85% alcohol heat reflux, Extracting temperature 50-
75 DEG C, merge extract solution, be concentrated into no alcohol taste and obtain concentrate；To the above-mentioned concentrate extracting n-butyl alcohol of step, positive fourth is obtained
Alcohol extract；By n-butyl alcohol extract AB-8 type macroporous resin enrichments, first with distillation water elution, then 60% ethanol elution is used,
60% ethanol eluate is collected, is concentrated under reduced pressure, is spray-dried, obtains the Atractylis chinensis rhizome extract.
3. the acne-removing composition of a kind of Sage Extract according to claim 1, it is characterised in that the papaya extractives
Preparation method is：Papaya tablet is decocted 2-3 times with vapor heating, it is each 1-2 hours；Filter to get filtrate, filtrate is heated dense
70-85% ethanol precipitations are used after contracting；The alcohol clear liquid heating concentration of acquisition obtains medicinal extract shape papaya extractives.
4. the acne-removing composition of a kind of Sage Extract according to claim 1, it is characterised in that the biennial wormwood extract
Preparation method is：Dry mugwort leaf is crushed, solid material is obtained；Solid material is added into deionized water soaked overnight, solid-liquid
It is 1 than (g/ml):15-1:20；Take above-mentioned heating and refluxing extraction 2-3 times, extraction time is 1-3h, 60-75 DEG C of Extracting temperature；Close
And filtrate；Filtrate is filtered to remove impurity；Filtrate decompression is concentrated and dried to obtain dried object；Dried object was crushed after 65-80 mesh sieves
Obtain the biennial wormwood extract.
5. application of the acne-removing composition of the Sage Extract according to claim any one of 1-4 in cosmetics are prepared.
6. application according to claim 5, it is characterised in that the cosmetics are Essence.
7. a kind of Essence, it is characterised in that the Essence is consisted of the following composition：
0.2-3 parts of the acne-removing composition of Sage Extract as described in claim any one of 1-4
25-30 parts of NMF
0.05-0.1 parts of chelating agent
0.1-0.3 parts of preservative
Deionized water adds to 100 parts.
8. a kind of Essence according to claim 1, it is characterised in that the NMF is 1,3-BDO, hyalomitome
At least one of sour sodium, DPG, glycerine, propane diols, butanediol；The chelating agent is EDETATE SODIUM, Etidronic Acid
At least one of；The preservative is at least one of methyl hydroxybenzoate, Nipasol, Phenoxyethanol.
9. a kind of preparation method of Essence as claimed in claim 7, it is characterised in that the preparation method includes following step
Suddenly：NMF, chelating agent, deionized water are mixed and be heated to 70-80 DEG C and be completely dissolved it；It is cooled to after 45 DEG C, according to
Secondary acne-removing composition, the preservative for adding Sage Extract described in claim 1, stirs, low temperature discharging.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710196628.7A CN106974858A (en) | 2017-03-28 | 2017-03-28 | A kind of acne-removing composition of Sage Extract and its application |
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| CN201710196628.7A CN106974858A (en) | 2017-03-28 | 2017-03-28 | A kind of acne-removing composition of Sage Extract and its application |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494271A (en) * | 2020-06-19 | 2020-08-07 | 广州智尚生物科技有限公司 | Atractylodes lancea rhizome and hypericum perforatum mixed extract and preparation method and application thereof |
| CN114796051A (en) * | 2022-04-28 | 2022-07-29 | 陆文勇 | Whitening and moisturizing mask with acne removing effect and preparation method thereof |
| CN116585242A (en) * | 2023-07-11 | 2023-08-15 | 同芙国际控股集团有限公司 | Moisturizing and soothing composition and preparation method thereof |
-
2017
- 2017-03-28 CN CN201710196628.7A patent/CN106974858A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494271A (en) * | 2020-06-19 | 2020-08-07 | 广州智尚生物科技有限公司 | Atractylodes lancea rhizome and hypericum perforatum mixed extract and preparation method and application thereof |
| CN111494271B (en) * | 2020-06-19 | 2022-10-28 | 广州智尚生物科技有限公司 | Atractylodes lancea rhizome and hypericum perforatum mixed extract and preparation method and application thereof |
| CN114796051A (en) * | 2022-04-28 | 2022-07-29 | 陆文勇 | Whitening and moisturizing mask with acne removing effect and preparation method thereof |
| CN116585242A (en) * | 2023-07-11 | 2023-08-15 | 同芙国际控股集团有限公司 | Moisturizing and soothing composition and preparation method thereof |
| CN116585242B (en) * | 2023-07-11 | 2023-09-15 | 同芙国际控股集团有限公司 | Moisturizing and soothing composition and preparation method thereof |
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Application publication date: 20170725 |