CN104434609A - Compound traditional Chinese medicine extract with acne removing function and application thereof in cosmetics - Google Patents
Compound traditional Chinese medicine extract with acne removing function and application thereof in cosmetics Download PDFInfo
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- CN104434609A CN104434609A CN201310439061.3A CN201310439061A CN104434609A CN 104434609 A CN104434609 A CN 104434609A CN 201310439061 A CN201310439061 A CN 201310439061A CN 104434609 A CN104434609 A CN 104434609A
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Abstract
The invention discloses a compound traditional Chinese medicine extract with an acne removing function and application thereof in cosmetics. The compound traditional Chinese medicine extract disclosed by the invention contains the following traditional Chinese medicine ingredients in percentage by weight: 1-25% of honeysuckle flowers, 1-20% of loquat leaves, 1-25% of forsythia fruit, 1-15% of radix scutellariae, 1-20% of Chinese holly, 1-25% of herba andrographitis, 1-20% of tribulus terrestris and 1-25% of mulberry barks. The compound traditional Chinese medicine extract disclosed by the invention has good effects of controlling the secretion of oils and fats, dredging sweat pores, carrying out bacteriostasis and disinfection and removing acnes. The composition does not contain chemically-synthesized substances, is free from toxic or side effects, is low in skin irritation and stable in nature, and is safe and reliable.
Description
Technical field
The present invention relates to a kind of compound Chinese medicine extract, this compound Chinese medicine extract has acne-removal function, can be applied in acne-eliminating cosmetic.
Background technology
Pox is being commonly called as of acne, is again " comedo ", " skin sore " or " acne ", is a kind of dermatosis because hair follicle and sebaceous gland are blocked, inflammation causes.During adolescence, hormone superfluous in body can grow by stimulating hair fast, and smegma is heavy wool fat more, and hair and sebaceous gland be overheap material therefore, and oils and fats and antibacterial are more easily adhered to, and causes the reaction of red swelling of the skin.Because this symptom is common in youth of both sexes, so just claim it to be " comedo ".Anti-acne is the process using Medical Technology or method to eliminate comedo.
At present, the active matter mainly two large classes of conventional acne-removal function: is chemicals, as sulfur, resorcinol, salicylic acid, benzoyl peroxide etc., there is the shortcomings such as large, the irritated rate of side effect is high in this kind of active matter; Two is antibiotic or phage species, such as metronidazole, chloromycetin, erythromycin etc., and this kind of active matter is very large to human injury, also there is the shortcomings such as large, the irritated rate of zest is high.In order to overcome chemicals and antibiotic to the harm of human body, present anti-acne starts to turn to use natural active products, a kind of there is anti-acne as patent of invention ZL200710078403.8 discloses, fill out hole, the herbal mixture of speckle removing effect and preparation method thereof, said composition is made up by weight of following crude drug: Rhizoma Acori Graminei 10 parts, Fructus Schisandrae Chinensis 8 parts, Fructus Bruceae 1 part, Cortex Acanthopancis 3 parts, Radix Et Rhizoma Rhei 2.5 parts; Patent of invention ZL200910235809.1 discloses a kind of compound acne-removing Chinese medicine extract and preparation method thereof, and described Chinese medicine is Radix Salviae Miltiorrhizae, Flos Caryophylli, Radix Scutellariae, Radix Et Rhizoma Rhei magnolia obovata; Patent of invention ZL201110353736.3 discloses the acne eliminating cream of a kind of anti-acne natural extract compositions and preparation thereof, and described anti-acne natural extract compositions is glycerol, Radix Scutellariae extracting solution, Radix Scutellariae extracting solution, Flos Lonicerae extractive solution, Radix Sophorae Flavescentis extractive liquid.
Summary of the invention
The first object of the present invention is to provide a kind of compound Chinese medicine extract with acne-removal function, and this compound Chinese medicine extract has acne-removal function.
Another object of the present invention is used in acne-eliminating cosmetic by above-mentioned compound Chinese medicine extract, makes stable in properties, respond well acne-eliminating cosmetic.
For realizing the first object of the present invention, present invention employs following technical scheme: a kind of herbal mixture with acne-removal function, it is characterized in that the component comprising following percentage by weight: Flos Lonicerae 1 ~ 25%; Folium Eriobotryae 1 ~ 20%; Fructus Forsythiae 1 ~ 25%; Radix Scutellariae 1 ~ 15%; Ilex purpurea Hassk.[I.chinensis Sims 1 ~ 20%; Herba Andrographis 1 ~ 25%; Fructus Tribuli 1 ~ 20%; Cortex Mori 1 ~ 25%.
For obtaining above-mentioned compound Chinese medicine extract, present invention employs following technical scheme: the Flos Lonicerae in above-mentioned herbal mixture, Folium Eriobotryae, Fructus Forsythiae, Radix Scutellariae, Ilex purpurea Hassk.[I.chinensis Sims, Herba Andrographis, Fructus Tribuli, Cortex Mori are pulverized, mix homogeneously after sieving, add Extraction solvent, heating and refluxing extraction 1 ~ 3 time, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product.In order to avoid dissolvent residual, the Extraction solvent used in the present invention can adopt water, ethanol, ethanol water.
For realizing the second object of the present invention, present invention employs following technical scheme: by the application of the extract of above-mentioned herbal mixture in preparation acne-eliminating cosmetic, it is characterized in that its consumption is 0.05 ~ 25%, and preferable amount is 1 ~ 15% containing above-mentioned compound Chinese medicine extract in acne-eliminating cosmetic.Except the extract containing above-mentioned herbal mixture, suitably can add the usual composition that applicable acne-eliminating cosmetic uses as required, as matrix components such as wetting agent, emollient, water, emulsifying agent, thickening agents.
The dosage form of acne-eliminating cosmetic is not particularly limited, and can be solution, gel, emulsion, cream frost shape, spray etc.
Beneficial effect of the present invention: the extract of herbal mixture of the present invention is made up of natural materials, has control fat secretion, dredging pore, antibacterial sterilization, effect of anti-acne.In addition, except controlling oil, sterilization, anti-acne effect, these active ingredient of Chinese herbs, also have good scavenging free radicals, restraint of tyrosinase active function, have certain defying age and whitening function.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further illustrated, but these embodiments are just in order to illustrate, are not limitations of the present invention.
The preparation of embodiment 1 compound Chinese medicine extract (I)
Extracting honeysuckle 20g, Folium Eriobotryae 10g, Fructus Forsythiae 15g, Radix Scutellariae 5g, Ilex purpurea Hassk.[I.chinensis Sims 8g, Herba Andrographis 20g, Fructus Tribuli 10, Cortex Mori 12g, pulverize, cross mix homogeneously after 40 mesh sieves, add the ethanol water 1000g that mass fraction is 60%, heating and refluxing extraction 60min, repeat extraction 3 times, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product.
The preparation of embodiment 2 compound Chinese medicine extract (II)
Extracting honeysuckle 15g, Folium Eriobotryae 10g, Fructus Forsythiae 10g, Radix Scutellariae 10g, Ilex purpurea Hassk.[I.chinensis Sims 5g, Herba Andrographis 20g, Fructus Tribuli 15g, Cortex Mori 15g, pulverize, cross mix homogeneously after 40 mesh sieves, add the ethanol water 800g that mass fraction is 70%, heating and refluxing extraction 70min, repeat extraction 2 times, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product.
The preparation of embodiment 3 compound Chinese medicine extract (III)
Extracting honeysuckle 10g, Folium Eriobotryae 20g, Fructus Forsythiae 10g, Radix Scutellariae 15g, Ilex purpurea Hassk.[I.chinensis Sims 15g, Herba Andrographis 10g, Fructus Tribuli 11g, Cortex Mori 10g, pulverize, cross mix homogeneously after 40 mesh sieves, add the ethanol water 1200g that mass fraction is 50%, heating and refluxing extraction 90min, repeat extraction 2 times, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product.
Embodiment 4 minimal inhibitory concentration (MIC) is tested
Get the culture dish containing different compound Chinese medicine extract Concentraton gradient, be added drop-wise in above-mentioned culture dish with the examination bacterium that supplies that aseptic straw draws 0.1mL corresponding, smoothen, 37 with aseptic L-type Glass rod.Cultivate 24h at DEG C, compare with sterilized water, blank extracting solution and extract diluent, record observed result.Be the MIC of this extract there is no the least concentration of thalli growth completely.Testing result is shown in Table 1.
The MIC (mg/L) of the various bacterium of table 1
As can be seen from Table 1, the compound Chinese medicine extract that prepared by the present invention has good inhibition to various bacteria such as can causing the propionibacterium acnes of an acne.
Embodiment 5 acne eliminating cream and preparation method thereof
Table 2 provides the acne eliminating cream formula containing compound Chinese medicine extract, and the consumption of each material represents with mass fraction.
Table 2
The preparation method of acne eliminating cream: by the dimethyl siloxane in formula table, isopropyl palmitate, Miglyol 812, monoglyceride, stearic acid, 1618 alcohol, cetearyl glucoside, polyglycereol-3-methyl distearate, methyl hydroxybenzoate, propylparaben mixing, be heated to 80 DEG C, fusing stirs, as oil phase; By the 1,2-PD in formula table, compound Chinese medicine extract, deionized water mixing, join emulsifying pot and be heated to 85 DEG C, stirring and dissolving is even, as aqueous phase.Joined by oil phase in aqueous phase, stir, emulsifying homogeneous, after 6 minutes, when stirring is cooled to 50 DEG C, adds essence, stirs, be cooled to 38 DEG C, be acne eliminating cream.
The anti-acne index SPF of acne-eliminating cosmetic prepared in this embodiment is 15.
Embodiment 6 acne removing water and preparation method thereof
Table 3 provides the acne removing water formula containing compound Chinese medicine extract, and the consumption of each material represents with mass fraction.
Table 3
The preparation method of acne removing water: deionized water is heated to 85 DEG C, adds hydroxyethyl-cellulose, stirring and dissolving is even, adds 1,3 butylene glycol.When stirring is cooled to 50 DEG C, add other compositions, continue stirring and be cooled to 38 DEG C, be acne removing water.
The evaluation of embodiment 7 anti-acne effect
Evaluation object: select face have acne, the age be 15-30 year youngster 40 example, wherein male 20 example, women 20 example.
Evaluation methodology: adopt double-blind method, the acne removing water 3-5g that after every morning washed prepared by Example 5 is applied to the position having acne on the face, and repasting once after washed before sleep in evening, 20 days is a course for the treatment of.
Evaluation criterion: 1. effective: acne disappears and takes off more than 70%; 2. effective: acne disappears and takes off more than 30%; 3. invalid: acne disappears and takes off less than 30%.
Evaluation result: effective 23 examples, account for 57.5%; Effective 12 examples, account for 30%; Invalid 5 examples, account for 12.5%.Total effective rate reaches 87.5%.
Claims (3)
1. there is a compound Chinese medicine extract for acne-removal function, it is characterized in that herbal mixture comprises the Chinese medicinal components of following percentage by weight: Flos Lonicerae 1 ~ 25%, Folium Eriobotryae 1 ~ 20%, Fructus Forsythiae 1 ~ 25%, Radix Scutellariae 1 ~ 15%, Ilex purpurea Hassk.[I.chinensis Sims 1 ~ 20%, Herba Andrographis 1 ~ 25%, Fructus Tribuli 1 ~ 20%, Cortex Mori 1 ~ 25%; The manufacture method of compound Chinese medicine extract is: the Flos Lonicerae in above-mentioned herbal mixture, Folium Eriobotryae, Fructus Forsythiae, Radix Scutellariae, Ilex purpurea Hassk.[I.chinensis Sims, Herba Andrographis, Fructus Tribuli, Cortex Mori are pulverized, mix homogeneously after sieving, add Extraction solvent, heating and refluxing extraction 1 ~ 3 time, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product; Extraction solvent is water, ethanol, ethanol water.
2. compound Chinese medicine extract according to claim 1, it is characterized in that carrying out in the steps below: Flos Lonicerae, Folium Eriobotryae, Fructus Forsythiae, Radix Scutellariae, Ilex purpurea Hassk.[I.chinensis Sims, Herba Andrographis, Fructus Tribuli, Cortex Mori are pulverized, mix homogeneously after sieving, add Extraction solvent, heating and refluxing extraction 1 ~ 3 time, merge extractive liquid, with activated carbon decolorizing, filtration, filtrate, through being evaporated to extractum shape, to obtain final product; Extraction solvent is water, ethanol, ethanol water.
3. the application of compound Chinese medicine extract according to claim 1 in preparation acne-eliminating cosmetic, is characterized in that its consumption is 0.05 ~ 25%, and preferable amount is 1 ~ 15% containing compound Chinese medicine extract according to claim 1 in acne-eliminating cosmetic.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105219553A (en) * | 2015-10-12 | 2016-01-06 | 广西大学 | A kind of natural hand soaps and preparation method thereof |
| CN106491459A (en) * | 2016-12-22 | 2017-03-15 | 江西宜信堂医疗科技有限公司 | A kind of acne eliminating cream containing traditional Chinese medicine ingredients and preparation method thereof |
| CN107496267A (en) * | 2017-10-18 | 2017-12-22 | 佛山市飞时达新材料科技有限公司 | A kind of acne-eliminating cosmetic and preparation method thereof |
| CN108635315A (en) * | 2018-05-17 | 2018-10-12 | 东莞市卫花生物科技有限公司 | A kind of anti-acne antiseptic |
| CN113171322A (en) * | 2021-05-12 | 2021-07-27 | 清远市望莎生物科技有限公司 | Acne-removing composition, application thereof and acne-removing nano gel emulsion containing acne-removing composition |
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| KR20080101461A (en) * | 2007-05-18 | 2008-11-21 | 김수남 | Composition for preventing and curing acne |
| CN101934059A (en) * | 2010-08-03 | 2011-01-05 | 广东轻工职业技术学院 | Preparation method of extract of traditional Chinese medicine composition with bacteriocidal function and application thereof in daily chemical products |
| CN102125618A (en) * | 2011-02-25 | 2011-07-20 | 南方医科大学 | Medicine for treating lung meridian wind-heat type acne |
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2013
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080101461A (en) * | 2007-05-18 | 2008-11-21 | 김수남 | Composition for preventing and curing acne |
| CN101934059A (en) * | 2010-08-03 | 2011-01-05 | 广东轻工职业技术学院 | Preparation method of extract of traditional Chinese medicine composition with bacteriocidal function and application thereof in daily chemical products |
| CN102125618A (en) * | 2011-02-25 | 2011-07-20 | 南方医科大学 | Medicine for treating lung meridian wind-heat type acne |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105219553A (en) * | 2015-10-12 | 2016-01-06 | 广西大学 | A kind of natural hand soaps and preparation method thereof |
| CN106491459A (en) * | 2016-12-22 | 2017-03-15 | 江西宜信堂医疗科技有限公司 | A kind of acne eliminating cream containing traditional Chinese medicine ingredients and preparation method thereof |
| CN107496267A (en) * | 2017-10-18 | 2017-12-22 | 佛山市飞时达新材料科技有限公司 | A kind of acne-eliminating cosmetic and preparation method thereof |
| CN108635315A (en) * | 2018-05-17 | 2018-10-12 | 东莞市卫花生物科技有限公司 | A kind of anti-acne antiseptic |
| CN113171322A (en) * | 2021-05-12 | 2021-07-27 | 清远市望莎生物科技有限公司 | Acne-removing composition, application thereof and acne-removing nano gel emulsion containing acne-removing composition |
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| CN104434609B (en) | 2017-06-16 |
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Effective date of registration: 20170608 Address after: 510300 Xingang West Road, Guangzhou, Guangdong, Haizhuqu District Co-patentee after: GUANGZHOU QUEENBE COSMETICS CO., LTD. Patentee after: Guangdong Industry Technical College Address before: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee before: Guangdong Industry Technical College |
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