CN105434307B - A kind of Whelk-eliminating paste containing Chinese herbal medicine extract and preparation method thereof - Google Patents
A kind of Whelk-eliminating paste containing Chinese herbal medicine extract and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Abstract
The invention discloses a kind of Whelk-eliminating pastes containing Chinese herbal medicine extract and preparation method thereof, it is desirable to provide a kind of inhibition to propionibacterium acnes is stronger, and anti-acne effect is good, and safety is mild, does not have irritant Whelk-eliminating paste to human body；Technical points are made of the component of following mass percents：Emulsifier 6 10%, assistant for emulsifying agent 2 3%, grease 10 14%, antioxidant 0.4 0.6%, absorption enhancers 1.6 2.4%, acne-removing composition 5 7.5%, emulsifier thickener 1.6 2.4%, moisturizer 8 12%, preservative 0.2 1%, surplus is water；Wherein：100% in terms of acne-removing composition gross mass, each component mass percent is, camphor 6 10%, menthol 6 10%, peony root extractive 12 20%, sorrel root extract 28 40%, nutgall extractive 20 30%, Cortex Phellodendri extract 8 12%, belong to technical field of skin care.
Description
Technical field
The present invention relates to a kind of Whelk-eliminating paste and preparation method thereof more particularly to a kind of Whelk-eliminating paste containing Chinese herbal medicine extract and
Preparation method；Belong to technical field of skin care.
Background technology
Acne is commonly called as whelk, dark sore, acne, is a kind of chronic inflammatory skin of pilosebaceous follicle, main to occur
At the position that face, shirtfront, omoplate smegma are vigorous.It is one of most common disease of Skin cosmesis, incidence 70
~80%, recess, spot can be formed in skin surface, strong influence is generated with social to teen-age psychology.
The drug that clinical treatment acne uses is mainly chemical drugs such as topical Retinoids class drug, benzoyl peroxide, outer
With antibiotic etc., it will appear the irritative responses such as allergy and local erythema, furfur, burning sensation using excessive skin, skin made
Into secondary injury.The product for resolving poxes prepared using natural plant active component, it is safe and free of toxic and side effects, therefore increasingly by city
The favor of field.
The factor for inducing acne is varied, research shows that propionibacterium acnes and acne have close relationship.
Largely secretion leads to scytitis and pilosebaceous duct dyskeratosis, and then form micro mist for sebaceous glands Rapid development and lipid
Thorn and acne, micro mist thorn and acne block pore, are that the propionibacterium acnes of anaerobism create prolific good environment, directly
It connects and induces inflammation or exacerbation inflammation.
Invention content
Against the above deficiency, it the purpose of the present invention is to provide a kind of inhibition to propionibacterium acnes is stronger, dispels
Acne effect is good, and safety is mild, does not have irritant Whelk-eliminating paste containing Chinese herbal medicine extract and preparation method thereof to human body.
In order to solve the above technical problems, previous technical solution provided by the invention is such：
A kind of Whelk-eliminating paste containing Chinese herbal medicine extract, is made of the component of following mass percents：Emulsifier 6-10%, is helped
Emulsifier 2-3%, grease 10-14%, antioxidant 0.4-0.6%, absorption enhancers 1.6-2.4%, acne-removing composition 5-
7.5%, emulsifier thickener 1.6-2.4%, moisturizer 8-12%, preservative 0.2-1%, surplus is water；
Wherein：100% in terms of acne-removing composition gross mass, each component and its mass percent in the acne-removing composition
For camphor 6-10%, menthol 6-10%, peony root extractive 12-20%, sorrel root extract 28-40%, Chinese gall
Extract 20-30%, Cortex Phellodendri extract 8-12%, hamamelis extract 5-10% and Purslane extract 3-6%.
Preferably, the above-mentioned Whelk-eliminating paste containing Chinese herbal medicine extract, the emulsifier is stereth -2, stearyl alcohol
Polyethers -21, stearine, stearine/PEG-100 stearates, polysorbate -60, cetearyl Portugal
Glucosides, 14-22 alcohol, C12-20 alkyl glucosides, cetylstearyl alcohol, cocoyl glucoside, ceteareth -20
One of or arbitrary combination.
It is furthermore preferred that the above-mentioned Whelk-eliminating paste containing Chinese herbal medicine extract, 100% in terms of emulsifier gross mass, the emulsification
Each component and its mass percent are in agent, -2 18-28% of stereth, -21 22-35% of stereth, and glycerine is hard
Resin acid ester 22-35% and stearine/PEG-100 stearates 13-21%.
Preferably, the above-mentioned Whelk-eliminating paste containing Chinese herbal medicine extract, the grease is isopropyl myristate, hydrogenation is poly-
One of isobutene, dimethyl silicone polymer or arbitrary combination.
Preferably, the above-mentioned Whelk-eliminating paste containing Chinese herbal medicine extract, the assistant for emulsifying agent are cetostearyl alcohol.
Preferably, the above-mentioned Whelk-eliminating paste containing Chinese herbal medicine extract, the emulsifing thickener are hydroxypropul starch phosphoric acid
Ester.
Preferably, the above-mentioned Whelk-eliminating paste containing Chinese herbal medicine extract, the moisturizer are propylene glycol.
To prepare the above-mentioned Whelk-eliminating paste containing Chinese herbal medicine extract, latter solution provided by the invention is such：
1) each component is weighed；
2) emulsifier, assistant for emulsifying agent, the grease weighed step 1), which is added in oil phase pot, is warming up to 85~90 DEG C, heat preservation 15
~20min dissolves to obtain oil phase component；
3) moisturizer that weighs step 1), emulsifing thickener, water, which are added in water phase pot, is warming up to 85~90 DEG C, heat preservation 10
~15min dissolves to obtain water phase components；
4) under the conditions of 80-85 DEG C, 30~40r/min of mixing speed, the oil phase component, the step that successively prepare step 2)
3) water phase components prepared are pumped into emulsification pot, and open homogeneous blender, after 3~5min of 2500-3500r/min homogeneous, continue
10~20min of stirring must emulsify phase component；
5) emulsification phase component prepared by step 4) is cooled to 60~65 DEG C, adds in antioxidant, absorption enhancers, anti-acne group
Close object, while turn on agitator and homogeneous blender after 2~4min of 2500-3500r/min homogeneous, continue in 30~40r/min
Stir 6-15min, then be cooled to 40~45 DEG C, add in preservative, then 30~40r/min stir 15~20min to get into
Product.
Compared with prior art, technical solution provided by the invention has following technological merit：
1st, in technical solution provided by the invention, each component of strictly investigating, scientific compatibility, prepared Whelk-eliminating paste is to Cuo
The inhibition of sore Propionibacterium is stronger, and acne effect is good, and safety is mild, human body is not stimulated.
2nd, acne-removing composition contained in technical solution provided by the invention is using sorrel root extract as main antibacterial
Ingredient, is aided with the effect of peony root extractive, Cortex Phellodendri extract enhancing antibacterial anti-inflammatory, and compounding has five times of astriction
Seed extract promotes the healing of wound and the purulence that disappears, and addition camphor and menthol give the effect of the calm anti-inflammatory of formula increase simultaneously, can
Promote the absorption of antibacterial anti-inflammatory ingredient, increase the acne-removing of product.
3rd, contain tocopherol acetate in technical solution provided by the invention, there is antioxidation to reduce pigment deposition,
Shorten acne
The time that acne is eliminated.
4th, containing herbal component in technical solution provided by the invention, the safety validity for promoting product expands simultaneously
Chinese medicine day
The application of right extract
Specific embodiment
With reference to embodiment, the claim of the present invention is described in further detail, but do not formed pair
Any restrictions of the present invention, the modification of anyone limited number of time made in the claims in the present invention protection domain, still in this hair
Within bright claims.
Embodiment 1
Whelk-eliminating paste of the another kind containing Chinese herbal medicine extract provided by the invention, is made per 100kg Whelk-eliminating pastes of following components：
Cetearyl glucoside 3kg, stearine/PEG-100 stearate 3kg, cetostearyl alcohol 3kg, myristic acid are different
Propyl ester 10kg, Parleam 2kg, dimethyl silicone polymer 2kg, tocopherol acetate 0.4kg, Laurocapram 1.6kg,
Camphor 0.7kg, menthol 0.6kg, peony root extractive 1.5kg, sorrel root extract 2.2kg, nutgall extractive
1.8kg, Cortex Phellodendri extract 0.7kg, hydroxypropyl starch phosphate 1.6kg, propylene glycol 12kg, methyl hydroxybenzoate 0.2kg, oxybenzene
Propyl ester 0.1kg, Sensiva SC50 0.28kg, surplus are water.
Embodiment 2
Whelk-eliminating paste of the another kind containing Chinese herbal medicine extract provided by the invention, is made per 100kg of following components：14 alcohol
2kg, C20 alkyl glucoside 2kg, stearine 3kg, cetostearyl alcohol 2.5kg, isopropyl myristate 10kg, poly- two
Methylsiloxane 2kg, tocopherol acetate 0.5kg, Laurocapram 2kg, camphor 0.5kg, menthol 0.5kg, tree peony root carry
Object 1.5kg, sorrel root extract 2kg, nutgall extractive 1.0kg, Cortex Phellodendri extract 0.5kg are taken, hydroxypropyl forms sediment
Powder phosphate 2kg, propylene glycol 10kg, Phenoxyethanol 0.75kg, methylisothiazolinone 0.005kg, surplus is water.
Embodiment 3
Whelk-eliminating paste of the another kind containing Chinese herbal medicine extract provided by the invention, is made per 100kg Whelk-eliminating pastes of following components：
Cetylstearyl alcohol 1kg, cocoyl glucoside 1kg, stearine 2kg, ceteareth -20 2kg are sweet
Oleostearin acid esters/PEG-100 stearate 2kg, cetostearyl alcohol 3kg, isopropyl myristate 8kg, Parleam
2kg, dimethyl silicone polymer 2kg, tocopherol acetate 0.6kg, Laurocapram 2.2kg, camphor 0.5kg, menthol
0.5kg, peony root extractive 1kg, sorrel root extract 2.1kg, nutgall extractive 1.52kg, Cortex Phellodendri extract
0.63kg, hydroxypropyl starch phosphate 2.2kg, propylene glycol 10kg, methyl hydroxybenzoate 0.2kg, methylisothiazolinone 0.01kg are remaining
It measures as water.
Embodiment 4
Whelk-eliminating paste of the another kind containing Chinese herbal medicine extract provided by the invention, is made per 100kg Whelk-eliminating pastes of following components：
- 2 1.6kg of stereth, stereth -21 2.8kg, stearine 2.8kg, stearine/PEG-100
Stearate 1.3kg, cetostearyl alcohol 2.5kg, isopropyl myristate 10kg, Parleam 1kg, polydimethylsiloxanes
Alkane 1kg, tocopherol acetate 0.5kg, Laurocapram 2kg, camphor 0.4kg, menthol 0.4kg, peony root extractive 1kg,
Sorrel root extract 2kg, nutgall extractive 1.5kg, Cortex Phellodendri extract 0.8kg, hydroxypropyl starch phosphate
2kg, propylene glycol 10kg, Phenoxyethanol 0.8kg, surplus are water.
Embodiment 5
Whelk-eliminating paste of the another kind containing Chinese herbal medicine extract provided by the invention, is made per Whelk-eliminating paste 100kg of following components：
Stearine/PEG-100 stearate 8.5kg, cetostearyl alcohol 2.5kg, isopropyl myristate 8kg, hydrogenation are poly- different
Butylene 2kg, dimethyl silicone polymer 2kg, tocopherol acetate 0.5kg, Laurocapram 2kg, camphor 0.5kg, menthol
0.5kg, peony root extractive 1.25kg, sorrel root extract 2kg, nutgall extractive 1.25kg, Cortex Phellodendri extraction
Object 0.8kg, hydroxypropyl starch phosphate 2kg, propylene glycol 10kg, Phenoxyethanol 0.8kg, methylisothiazolinone 0.005kg are remaining
It measures as water.
Embodiment 6
A kind of Whelk-eliminating paste containing Chinese herbal medicine extract provided by the invention, is made of following components：Stereth -2
2kg, stereth -21 2.5kg, stearine 2.5kg, stearine/PEG-100 stearate 1.5kg,
Cetostearyl alcohol 2.5kg, isopropyl myristate 8kg, Parleam 2kg, dimethyl silicone polymer 2kg, tocopherol second
Acid esters 0.5kg, Laurocapram 2kg, camphor 0.5kg, menthol 0.5kg, peony root extractive 1kg, the extraction of sorrel root
Object 2.1kg, nutgall extractive 1.52kg, Cortex Phellodendri extract 0.63kg, hydroxypropyl starch phosphate 2kg, propylene glycol
10kg, Phenoxyethanol 0.8kg, surplus are water.
Embodiment 7
Whelk-eliminating paste of the another kind containing Chinese herbal medicine extract provided by the invention, is made per Whelk-eliminating paste 100kg of following components：
Stearine/PEG-100 stearate 8.5kg, cetostearyl alcohol 2.5kg, isopropyl myristate 8kg, hydrogenation are poly- different
Butylene 2kg, dimethyl silicone polymer 2kg, tocopherol acetate 0.5kg, Laurocapram 2kg, camphor 0.5kg, menthol
0.5kg, peony root extractive 1.25kg, sorrel root extract 2kg, nutgall extractive 1.25kg, Cortex Phellodendri extraction
Object 0.8kg, hamamelis extract 0.10kg, Purslane extract 0.3kg, hydroxypropyl starch phosphate 2kg, propylene glycol 10kg,
Phenoxyethanol 0.8kg, methylisothiazolinone 0.005kg, surplus are water.
Embodiment 8
A kind of Whelk-eliminating paste containing Chinese herbal medicine extract provided by the invention, is made of following components：Stereth -2
2kg, stereth -21 2.5kg, stearine 2.5kg, stearine/PEG-100 stearate 1.5kg,
Cetostearyl alcohol 2.5kg, isopropyl myristate 8kg, Parleam 2kg, dimethyl silicone polymer 2kg, tocopherol second
Acid esters 0.5kg, Laurocapram 2kg, camphor 0.5kg, menthol 0.5kg, peony root extractive 1kg, the extraction of sorrel root
Object 2.1kg, hamamelis extract 0.5kg, Purslane extract 0.6kg, nutgall extractive 1.52kg, Cortex Phellodendri extract
0.63kg, hydroxypropyl starch phosphate 2kg, propylene glycol 10kg, Phenoxyethanol 0.8kg, surplus are water.
The preparation method of Whelk-eliminating paste of any one in embodiment 1 to 8 containing Chinese herbal medicine extract, successively including following steps
Suddenly：
1) each component is weighed by any one group of mass number in embodiment 1 to 7；
2) emulsifier component, assistant for emulsifying agent, the oil component weighed step 1), which is added in oil phase pot, is warming up to 85~90
DEG C, 15~20min of heat preservation dissolves to obtain oil phase component；
3) moisturizer that weighs step 1), emulsifing thickener, water, which are added in water phase pot, is warming up to 85~90 DEG C, heat preservation 10
~15min dissolves to obtain water phase components；
4) under the conditions of 80-85 DEG C, 30~40r/min of mixing speed, the oil phase component, the step that successively prepare step 2)
3) water phase components prepared are pumped into emulsification pot, and open homogeneous blender, after 3~5min of 2500-3500r/min homogeneous, continue
10~20min of stirring must emulsify phase component；
5) emulsification phase component prepared by step 4) is cooled to 60~65 DEG C, adds in antioxidant, absorption enhancers, anti-acne group
Close object, while turn on agitator and homogeneous blender after 2~4min of 2500-3500r/min homogeneous, continue in 30~40r/min
Stir 6-15min, then be cooled to 40~45 DEG C, add in preservative component, then 30~40r/min stir 15~20min to get
Finished product.
Wherein：Said extracted object is respectively by the extracting method of following methods peony root extractive：10g tree peony roots is taken to drink
Piece is placed in flask, adds in 75wt% ethanol solution 100g, after impregnating 0.5h, the refluxing extraction 1h under 70 DEG C of water bath conditions, point
From extracting solution, the dregs of a decoction continuously add 75wt% ethanol solution 100g, and the refluxing extraction 1h at 70 DEG C obtains secondary raffinate, close
And two batches extracting solution.Tree peony root extracting solution is filtered using Buchner funnel, obtains clarified solution (tree peony root extracting solution).It will be clear
Clear liquid is placed in vacuum drying chamber, and 48h is continued drying out under conditions of temperature 70 C, vacuum degree -0.05MPa, obtains dry production
Object is crushed to get peony root extractive powder.
The extracting method of sorrel root extract：10g rhubarb decoction pieces are taken, are placed in flask, it is molten to add in 70wt% ethyl alcohol
Liquid 100g, after impregnating 0.5h, the refluxing extraction 1h under 80 DEG C of water bath conditions, extraction fluid, the dregs of a decoction continuously add 70wt% second
Alcoholic solution 100g, the refluxing extraction 1h at 80 DEG C obtain secondary raffinate, merge two batches extracting solution.Using Buchner funnel to big
Yellow extracting solution is filtered, and obtains clarified solution (Radix Et Rhizoma Rhei extract).Clarified solution is placed in vacuum drying chamber, in 80 DEG C of temperature,
48h is continued drying out under conditions of vacuum degree -0.05MPa, obtains desciccate, is crushed to get rheum officinale root extract powder.
The extracting method of nutgall extractive：10g Chinese gall medicine materical crude slice is taken, is placed in flask, adds in water 100g, impregnates 0.5h
Afterwards, the refluxing extraction 1h under 60 DEG C of water bath conditions, extraction fluid, the dregs of a decoction continuously add water 100g, the refluxing extraction at 60 DEG C
1h obtains secondary raffinate, merges two batches extracting solution.Chinese nutgall is filtered using Buchner funnel, is clarified
Liquid.Clarified solution is placed in vacuum drying chamber, continues drying out 48h under conditions of temperature 70 C, vacuum degree -0.05MPa, obtain
To desciccate, crush to get nutgall extractive powder.
The extracting method of Cortex Phellodendri extract：10g cork tree medicine materical crude slice is taken, is placed in flask, adds in 75wt% ethanol solutions
100g, after impregnating 0.5h, the refluxing extraction 1h under 80 DEG C of water bath conditions, extraction fluid, the dregs of a decoction continuously add 75wt% ethyl alcohol
Solution 100g, the refluxing extraction 1h at 80 DEG C obtain secondary raffinate, merge two batches extracting solution.Using Buchner funnel to cork tree
Extracting solution is filtered, and obtains clarified solution (Cortex Phellodendri extracting solution).Clarified solution is placed in vacuum drying chamber, in temperature 80
DEG C, 48h is continued drying out under conditions of vacuum degree -0.05MPa, obtains desciccate, is crushed to get Cortex Phellodendri extract
Powder.
The extracting method of hamamelis extract：10g witch hazels are taken, are placed in flask, add in water 100g, after impregnating 0.5h,
The refluxing extraction 1h under 60 DEG C of water bath conditions, extraction fluid, the dregs of a decoction continuously add water 100g, the refluxing extraction 1h at 60 DEG C,
Secondary raffinate is obtained, merges two batches extracting solution.Hazel extract is filtered using Buchner funnel, obtains clarified solution.
Clarified solution is placed in vacuum drying chamber, continues drying out 48h under conditions of temperature 70 C, vacuum degree -0.05MPa, done
Dry product is crushed to get hamamelis extract powder.
Purslane extract：10g purslane medicine materical crude slice is taken, is placed in flask, adds in 60wt% ethanol solution 100g, is impregnated
After 0.5h, the refluxing extraction 1h under 70 DEG C of water bath conditions, extraction fluid, the dregs of a decoction continuously add 60wt% ethanol solution 100g,
The refluxing extraction 1h at 70 DEG C obtains secondary raffinate, merges two batches extracting solution.Using Buchner funnel to Purslane extract into
Row filtering, obtains clarified solution (Purslane extract).
In order to better illustrate the advantages of present invention has, the anti-acne provided by the invention containing Chinese herbal medicine extract is given below
The effect of cream, tests：
1st, propionibacterium acnes bacteriostatic test
Test method：
Propionibacterium acnes (ATCC11827) tablet is prepared using double-layer agar technique, tablet bacteria containing amount is 104~105CFU/
Plate accurately weighs 0.5g samples, is uniformly applied on tablet containing bacterium with aseptic cotton carrier, is cultivated under anaerobic condition at 36 ± 1 DEG C
24 hours, then observe bacterium colony growth result in plate.
1) have no that bacterium colony grows (showing that sample is stronger to the inhibition of propionibacterium acnes, sample anti-acne effect is good)；
2) part bacterium colony growth (shows that sample has propionibacterium acnes certain inhibition, sample anti-acne effect
In)；
3) bacterium colony grows (show sample to propionibacterium acnes unrestraint effect, sample does not have anti-acne effect) completely.
Whelk-eliminating paste is taken to do propionibacterium acnes bacteriostatic test, the result is that having no that bacterium colony is grown, shows this Whelk-eliminating paste to acne
The inhibition of Propionibacterium is stronger, and sample anti-acne effect is good.
2nd, security test
3T3 red untake cytotoxicity tests
General permeability is 1%, 3T3 red untakes to the Whelk-eliminating paste containing Chinese herbal medicine extract that invention provides on the skin
Cytotoxicity test is not the results show that the Whelk-eliminating paste of 1% concentration influences the activity of 3T3 cells；
Whelk-eliminating paste shows that this Whelk-eliminating paste is to 3T3 cells to IC50 (half lethal concentration) test result of 3T3 cells
IC50 (half lethal concentration) is 36400 μ g/ml
LD50 is calculated as 5256.9mg/kg by acute oral toxicity and cytotoxicity model, is carried out using GHS anxious
Property Oral toxicity classification, which does not predict acute oral toxicity not in the range of toxicity grading.
Whelk-eliminating paste safety provided by the invention is mild in summary, it is irritant not have to human body.
Claims (4)
1. a kind of Whelk-eliminating paste containing Chinese herbal medicine extract, which is characterized in that be made of the component of following mass percents：Emulsifier
6-10%, assistant for emulsifying agent 2-3%, grease 10-14%, antioxidant 0.4-0.6%, absorption enhancers 1.6-2.4%, anti-acne combination
Object 5-7.5%, emulsifing thickener 1.6-2.4%, moisturizer 8-12%, preservative 0.2-1%, surplus are water；
Wherein：100% in terms of acne-removing composition gross mass, each component and its mass percent are camphor tree in the acne-removing composition
Brain 6-10%, menthol 6-10%, peony root extractive 12-20%, sorrel root extract 28-40%, Chinese gall extraction
Object 20-30%, Cortex Phellodendri extract 8-12%, hamamelis extract 5-10% and Purslane extract 3-6%；
The emulsifier is stereth -2, stereth -21, stearine, stearine/PEG-
100 stearates, polysorbate -60, cetearyl glucoside, 14-22 alcohol, C12-20 alkyl glucosides, cetyl
One of octadecanol, cocoyl glucoside, ceteareth -20 or arbitrary combination；
The grease is isopropyl myristate, Parleam, one of dimethyl silicone polymer or arbitrary
Combination；
The assistant for emulsifying agent is cetostearyl alcohol；
The emulsifing thickener is hydroxypropyl starch phosphate.
2. the Whelk-eliminating paste according to claim 1 containing Chinese herbal medicine extract, which is characterized in that in terms of emulsifier gross mass
100%, each component and its mass percent are -2 18-28% of stereth in the emulsifier, stereth -21
22-35%, stearine 22-35% and stearine/PEG-100 stearates 13-21%.
3. the Whelk-eliminating paste according to claim 1 containing Chinese herbal medicine extract, which is characterized in that the moisturizer is the third two
Alcohol.
4. prepare the method for the Whelk-eliminating paste described in claim 1 containing Chinese herbal medicine extract, which is characterized in that successively including following
Step：
1) mass percent as described in claim 1 weighs each component；
2) emulsifier that weighs step 1), assistant for emulsifying agent, grease, which are added in oil phase pot, is warming up to 85~90 DEG C, and heat preservation 15~
20min dissolves to obtain oil phase component；
3) moisturizer that weighs step 1), emulsifing thickener, water, which are added in water phase pot, is warming up to 85~90 DEG C, and heat preservation 10~
15min dissolves to obtain water phase components；
4) under the conditions of 80-85 DEG C, 30~40r/min of mixing speed, the oil phase component, the step 3 that successively prepare step 2) are made
Standby water phase components are pumped into emulsification pot, and open homogeneous blender, after 3~5min of 2500-3500r/min homogeneous, continue to stir
10~20min must emulsify phase component；
5) emulsification phase component prepared by step 4) is cooled to 60~65 DEG C, adds in antioxidant, absorption enhancers, anti-acne combination
Object, while turn on agitator and homogeneous blender after 2~4min of 2500-3500r/min homogeneous, continue to stir in 30~40r/min
6-15min is mixed, then is cooled to 40~45 DEG C, adds in preservative, then 15~20min is stirred to get finished product in 30~40r/min.
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| WO2020043365A1 (en) * | 2018-08-28 | 2020-03-05 | Beiersdorf Ag | Acrylate-free cosmetic emulsion |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020043363A1 (en) * | 2018-08-28 | 2020-03-05 | Beiersdorf Ag | Acrylate-free cosmetic emulsion |
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