KR20080090186A - Composition for the acceleration of hair growth - Google Patents

Abstract

A composition comprising herb medicine is provided to improve safety to human body by using natural products, and enhance hair growth-stimulating and accelerating and hair tonic effects. A composition for acceleration of hair growth comprises 0.1-15 wt.% of bamboo salt and 0.1-20 wt.% of Acorus gramineus, and optionally 0.1-80 wt.% of one herb medicine selected from Chrysanthemum morifolium RAMAT., Eugenia caryophyllata THUNB., Lycium chinense, Pinellia ternata tuber, Mentha arvensis L., Acanthopanax sessiliflorus SEEM., Sophora flavescens Aiton, Thuja orientalis Linn, Rubus coreanus MIQ, Panax ginseng C.A Meyer, Zingiber officinale rhizome, Angelica gigas Nakai, Hordeum vulgare var. and a mixture thereof, and formulated as paste, infusion, decoction, tinc agent, extract, fluid extract, syrup, ointment or cream.

Description

Composition for promoting hair growth {COMPOSITION FOR THE ACCELERATION OF HAIR GROWTH}

1 is a photograph showing the change in the number of hair follicles after administration of the composition of the present invention to mice,

Figure 2 is a photograph showing the degree of hair growth after applying the composition of the present invention to mice,

3 is a result of observing the degree of hair loss inhibition and hair growth after administration of the composition of the present invention to the hair loss patient.

The present invention relates to a composition for promoting hair growth having excellent effects of hair growth, hair growth and wool, containing bamboo salt and Acorus gramineus as an active ingredient.

The human hair is about 100,000 to 150,000, each hair has a different cycle and grow and drop out through the anagen, catagen and telogen. This cycle is repeated over three to six years, with an average of 50 to 100 hairs falling out per day. In general, alopecia refers to an increase in the number of hairs that are abnormally dropped due to shortening of the hair growth rate in the growth phase and more hair in the degenerative or resting period. The causes of alopecia have been discussed, such as poor blood circulation, excessive male hormone action, excessive sebum secretion, peroxide, bacteria, hypodermic function, genetic factors, aging, stress. However, to date, no clear cause for hair loss is known, and in recent years, a growing number of people are suffering from hair loss due to changes in diet and stress caused by social environment. Products that are currently marketed as hair growth promoting or hair loss preventing agents against various and complex hair loss causes growth period induction effect, hair growth period extension effect, 5α-reductase inhibitory effect, blood circulation promoting effect, bactericidal effect, anti-dandruff effect, moisturizing Efficacy by mechanisms such as the effect, antioxidant effect is intended. However, the products are not sufficient to prevent hair loss, promote hair growth, and cause problems.

On the other hand, herbal medicines have the advantage of low development cost and short development period as well as high added value compared to drugs extracted from synthetic compounds by using mainly natural raw materials. Currently, there are no drugs that have been certified as a product produced in Korea as a herbal medicine for hair loss treatment, and cosmetics and soaps have not been proven effective. In addition, more than 90% of hair growth, wool-related medicines, cosmetics, shampoos, soaps, etc. are imported from abroad, and the growth rate of imports is being accelerated. Among the natural hair loss treatments used overseas, products with a high market share include saw palmetto, green tea, pygeum, emu oil, and pumpkin seed. Pantogar ™ (MERZ, Germany), which contains medicinal yeast as an active ingredient, is mainly prescribed to female alopecia patients, but currently there are only two FDA-approved drugs for hair growth and wool. There are dozens of products, but most of them have not been recognized for their effectiveness.

Thus, the inventors of the present invention while studying the safe hair growth promoting agent having a hair growth promoting effect, to prepare a composition containing the bamboo salt and changchangpo extract as an active ingredient as an active ingredient, and tested the result, excellent safety to the human body As well as confirming that the hair growth, hair growth and wool effect is excellent and completed the present invention.

Accordingly, an object of the present invention is to provide a composition for promoting hair growth, which is excellent in hair growth, hair growth and wool effects, and also excellent in human safety.

In accordance with the above object, the present invention provides a composition for promoting hair growth comprising bamboo salt and stone spear as an active ingredient.

Hereinafter, the present invention will be described in detail.

The composition for promoting hair growth according to the present invention is characterized in that it contains bamboo salt and stone spear as essential ingredients. Bamboo salt may be included in an amount of 0.1 to 15% by weight, preferably 0.1 to 5% by weight based on the total composition. In addition, the stone spear can be included in an amount of 0.1 to 20% by weight, preferably 0.1 to 13% by weight based on the total composition. Instead of the bamboo salt may be used a mixture of bamboo salt and salt, wherein the mixing ratio of bamboo salt and salt may range from 1: 5 to 1:15.

The bamboo salt and stone spear can be used commercially available without limitation.

In addition, the composition for promoting hair growth according to the present invention is Chrysanthemum indicum , cloves ( Syzygium aromaticum ), phalanx (root bark of Lycium chinense Miller), Pinellia ternata , peppermint ( Mentha arvensis var piperascens ), Acanthopanax senticosus, red ginseng ( Sophora flavescens ), cypresses (young branches and leaves of Thuja orientalis L.), bokbunja (fruit of Rubus coreanus Miquel), ginseng ( Ponax) ginseng CAMey. ), ginger ( Zingiber officinale Roscoe ), Angelica (root of Angelica gigas Nakai), malt ( Hordeum vulgare var.hexastichon (L.) Asch. ) and a mixture thereof It may further comprise, preferably may further comprise a side of the white leaf, ginseng and malt. At this time, these herbal ingredients may be included in 0.1 to 80% by weight based on the total composition, preferably from 50 to 80% by weight.

The components included in the composition of the present invention may be an extract, and the extraction method may use a known method. For example, each herbal medicine is dried by natural drying or forced drying, and finely chopped, followed by polar solvents such as water, ethanol, butanol and acetone; Nonpolar solvents such as ether, hexane, benzene, chloroform and ethyl acetate; Mixtures thereof; Alkaline water; Alternatively, the above components may be extracted using vegetable oils such as soybean oil, sesame oil, and the like, and may be chilled, permeated or heated. In the case of cold acupuncture and water permeation, it is about 12 hours to 96 hours, and in the case of a warm needle, depending on the type and temperature of the solvent used, about 5 to 30 ml of solvent is added per 1 g of crude medicine, In about 30 minutes to 24 hours.

Extracts of the present invention are particularly preferred tinctures or liquid extracts leached from 30 to 60% of hydrous alcohols, and are traditionally formulated, that is, about 600 g of herbal medicines in 3000 to 7000 cc of water for about 2 to 4 hours It is also possible to use an extract obtained by extraction at from 90 ℃.

In addition, the composition of the present invention can be formulated in the form of a coating agent that can be applied to the skin leach diluent or ethanol diluent of the leach solution, general herbal preparations, ie, acupuncture, premises, tinctures, extracts, liquid extracts, syrups It can be formulated into internal and external preparations, such as ointments and cream preparations. At this time, in the case of the formulation of the type applied to the hair, a buffer may be added to adjust the pH, for example, sodium monophosphate, sodium diphosphate, sodium triphosphate, citric acid, sodium citrate, tartaric acid, tartaric acid Sodium, boric acid, phosphoric acid, hydrochloric acid, sodium hydroxide and the like can be used, preferably sodium monophosphate, sodium triphosphate or a mixture thereof can be used.

In addition, the composition of the present invention can be used as a medicinal cosmetic in combination with hair cosmetics such as wool, hair tonic, hair lotion, hair cream, shampoo and rinse, and contains a skin absorption promoting substance to increase the efficacy of the active ingredient. can do.

The dosage of these preparations may vary depending on the patient's age, symptoms, and method of administration, but in the case of external preparations, it is preferable to apply 1 to 3 ml to the affected area 1 to 5 times a day for more than 1 month. .

In addition, the composition of the present invention may contain a variety of well-known materials, which are usually formulated into cosmetics that are expected to hair growth and hair growth effect, if necessary, for example, vasodilators such as capronium chloride; Vitamins such as calcium pantothenate, vitamin A acetate, and pantothenyl alcohol; Amino acids such as methionine and serine; Anti-inflammatory agents such as diphenhydramine hydrochloride; Fungicides such as benzalkonium chloride and the like.

Hereinafter, the present invention will be described in more detail with reference to the following Examples and Test Examples. However, the following Examples and Test Examples are only for illustrating the present invention, but the scope of the present invention is not limited thereto.

Example 1: Preparation of a solid composition for promoting hair growth

250 g of changchangpo was quantified and placed in the lower part of the reaction tank of the water heater, and 1500ml of distilled water was poured and then filtered, and the filtrate was filtered by a Buchner funnel, and the filtrate was cooled in a bottle. After adding nine times the volume of alcohol to the filtrate and stirring for three and a half hours, the alcohol solution was put into a round flask and concentrated under reduced pressure using a reduced pressure concentrator (TOKYO RIKAIKAI CO., LTD) and cooling water at about 5 ° C. and dried. After obtaining the extract, distilled water was added and concentrated under reduced pressure again in the same manner. The obtained extract was filtered through a 0.2 μm cellulose filter paper, preliminarily frozen in a freezer at −30 ° C., removed with water in a freeze dryer (Bondiro), and dried to obtain stone powder. 100 ml of 25% bamboo salt aqueous solution was added to the stone powder, filtered through a 0.2 μm cellulose filter paper, and subdivided into 5 ml each of 10 ml glass bottles, which were placed in a freeze dryer chamber and lyophilized at −50 ° C. to give a solid state. The composition of was obtained.

Example 2: Preparation of liquid composition for promoting hair growth

5 mg each of bamboo salt, Seokchangpo, baekryeop, ginseng, and malt were finely mixed, and 150ml of 30% hydrous ethanol was added thereto, and the mixture was cooled at room temperature for 48 hours, and then extracted using an extractor (TOKYO RIKAIKAI CO., LTD.). The extract obtained by heating at 70 ° C. was purified by a pressure reducer (TOKYO RIKAIKAI CO., LTD.) And filtered through a Buchner funnel to obtain 100 ml of the extract. The extract was concentrated to dryness to obtain 4 g of dry extract, and then a 30% hydrous ethanol solution containing 5% thereof was prepared.

Example 3: Preparation of hair spreading composition for promoting hair growth

7000 ml of water was added to 80 g of Seokchangpo, Gamguk, Clove, Phalanx, Panax Mint, Mint, Prickly Pear, Red Ginseng, Cucumber, Bokbunja, Ginseng, Ginger, Angelica and Malt, and extracted at 90 ° C for 4 hours. Thereafter, 100 g of bamboo salt was added thereto. After adding the extract and the solubilizing agent to ethanol and completely dissolving the mixture, the mixture was sufficiently stirred, and then added to the purified water part (10% oil, 85% distilled water and 5% emulsifier) prepared in advance while stirring to completely solubilize. Filtration was applied by the method of preparing a hair restorer composition.

Example 4: Preparation of oral administration composition for hair growth promotion

10 mg each of Seokchangpo, Ephedra, Ginseng and Malt; And 5 mg each of ginseng, cloves, phalanges, pan-fried peppermint, peppermint, prickly pear, red ginseng, bokbunja, ginger, donkey, and bamboo salt in the same manner as in Example 1 to obtain dry extract 20 mg, and then extract in the usual manner. The agent was prepared.

Test Example 1 Measurement of Change in Mouse Hair Follicle Number

For 47-50-week-old male mice (C57BL / 6), the composition prepared in Example 2 was administered once a day for 30 days, 0.03 mg, three times a day, and then orally administered to observe hair follicle changes. . As for the control group, 3 mice, the composition 1 administration group, the 3 administration group, and the 10 administration group were used 6 mice each. As a result of observing hair follicle changes in each mouse after 30 days, the number of hair follicles was increased in the group to which the composition of the present invention was administered as compared to the control group, as shown in FIG. And both increased in size. In addition, the histological abnormalities were not found in the liver, kidney, and nervous system samples of the administration group, so that there were no side effects.

Test Example 2 Measurement of Change in Mouse Hair Count

The back hairs and back hairs of 47-50 week old male white mice (C57BL / 6) were removed and 100 μl of the composition prepared in Example 3 was applied twice a day only on the right side around the midline of the lateral plane. As a result of measuring the length of the hair at an interval of 1 day, as shown in FIG. 2, the hairs of the back and the back hairs showed more growth on the applied side (right) from the 7th and 14th days, respectively.

Test Example 3: Hair loss inhibition and hair growth test

Eight male patients undergoing hair loss were administered with the extract prepared in Example 4 three times in an amount of 6 to 9 g per day, and hair loss inhibition and hair growth were observed for three months. As a result, as shown in FIG. 3, hair loss was stopped in 6 of 8 people who participated in the experiment after 1 month, and showed hair growth that was visually confirmed after 3 months, and no other side effects were observed.

Test Example 4: Determination of Heavy Metal Content

The heavy metal content of the compositions prepared in Examples 3 and 4 was examined in the heavy metal laboratory in Chonnam National University. As a result, as shown in Table 1, the composition of the present invention was found to be less than the allowable heavy metal content was determined to be safe for the human body.

As described above, the composition according to the present invention can be used as an effective preparation for hair growth because it is excellent in the effects of hair growth, hair growth and wool, and also excellent in the human body by using herbal ingredients. have.

Claims (11)

Composition for promoting hair growth comprising bamboo salt and stone spear as an active ingredient. The method of claim 1, The bamboo salt and stone swelling, characterized in that it comprises 0.1 to 15% by weight and 0.1 to 20% by weight relative to the total composition, hair growth promoting composition. The method of claim 1, Instead of the bamboo salt, characterized in that containing a mixture of bamboo salt and salt, hair growth promoting composition. The method of claim 3, wherein Bamboo salt and salt mixing ratio of 1: 5 to 1:15, characterized in that the hair growth promoting composition. The method of claim 1, Hairy plant, characterized in that it further comprises a herbal medicine selected from the group consisting of persimmon soup, cloves, phalanges, specks, peppermint, prickly pear, ginseng, cedar, bokbunja, ginseng, ginger, donkey, malt and mixtures thereof Promotional composition. The method of claim 5, The herbal medicine is characterized in that it comprises 0.1 to 80% by weight relative to the total composition, hair growth promoting composition. The method of claim 5, The hair growth promoting composition is characterized in that it comprises bamboo salt, stone spear, baekyeop, ginseng and malt, hair growth promoting composition. The method according to claim 1 or 5, Said changchangpo or herbal medicine is characterized in that the form of extract, hair growth promoting composition. The method of claim 8, The extract may be a polar solvent, a nonpolar solvent or a mixture thereof; Alkaline water; Or plant oil, characterized in that prepared using a composition for promoting hair growth. Hair growth promoting agent prepared from the composition for promoting hair growth according to claim 1 or 5. The method of claim 10, The hair growth promoting agent is characterized in that the hair growth promoting agent is selected from coatings, acupuncture, premises, tinctures, extracts, liquid extracts, syrups, ointments and creams.

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