KR950006061B1 - Hair growing composition - Google Patents

Abstract

The hair growth promoting compound contained essentially the extracts of the fruit of Cornus officinalis S. et Z (Cornaceae), Eclipta prostrata (Compositae), and fruit of Mulberry alba (Moraceae). Thus, 10gm Cornaceae, 10gm Compositae, and 5 gm Moraceae were mixed, in which 30% ethanol 150ml was added and maintained 48hrs at room temperature and then extracted at 60-70≰C to give hair growth promoting compound.

Description

Hair growth promoting composition

Figure 1 is an external morphological change picture showing the hair growth process according to the hair growth promoting composition of the present invention.

2 is a graph showing the results of the cell growth promoting effect test of the hair growth promoting composition of the present invention.

The present invention relates to a hair growth promoting composition containing an extract composed of a certain kind of herbal medicine.

Conventionally, as a cause of baldness and hair loss, (1) the theory of the action of testosterone in organs such as the hair roots and sebaceous glands (2) the decrease in blood flow to the follicles (3) the scalp abnormalities due to excessive sebum secretion, the production of peroxides, and the growth of bacteria (4) genetic factors (5) aging and the like have been discussed. However, no clear cause for hair loss has yet been identified, and in recent years, more and more people are suffering from alopecia, and their age is decreasing.

As for the treatment of alopecia, there is no clear effect yet, and based on experience in the past, a compound having the action of applying physical stimulation to the head with a brush or removing or alleviating the cause has been formulated.

There are more than 1.3 million hairs and 100,000 hairs in the human body. These hairs go through three stages of growth, anagen, catagen, and telogen. Hair loss, which means less or no hair than normal due to hair or hair for some reason, can be distinguished from general hair loss (telogen effluvium) in which hair falls out of a resting state and anagen effluvium, which is abnormal hair loss. In general, the term alopecia refers to the latter.

Types of alopecia include alopecia areata, premature alopecia, and alopecia alopecia in women, syphilis alopecia, and male pattern baldness.

Conventionally, there are preparations based on female hormones related to hormonal theory in the treatment of such alopecia, but there are reports of not only effects but also skin irritation and side effects caused by hormone administration. Roh is distributed in the United States of the United States Minoxidil (minoxidil), Italy, Crinos (Crinos, Co.) trichosaccharide (richosaccharide) as a main ingredient, but the side effects such as lack of obvious effects and human stability has emerged have.

Therefore, the present inventors have closely observed the recent deterioration and increase in the number of alopecia patients, influenced the prevention and hair loss of hair loss, and selected and researched and selected materials from which natural biomaterials are also secured. Confirmed that the composition prepared by the extraction extraction has the effect of promoting hair growth and completed the present invention.

That is, the present invention is to provide a growth promoting composition which is safe for the living body in natural products and can achieve hair loss prevention and hair growth promoting effect.

When described in detail with respect to the hair growth promoting composition centered on the technical content of the present invention that can achieve the object as described above.

The hair growth promoting composition according to the present invention essentially contains extracts of cornus and nasturtium, and further contains one or more herbal extracts selected from the group consisting of red ginseng, cabbage, earthenware, black bean, mulberry, fat milk, dew, and aloe. It is characterized by. These terms do not limit the herbal medicine itself, but a leaching, transferring, extract, extract, etc. prepared by partially or totally leaching, transferring, or leaching liquid from the herbal medicine, or drying the concentrate again. (Hereinafter referred to as "extract extract") and chemicals contained in herbal medicines and which have a main effect.

The scientific names of various herbal medicines used in the present invention are as follows.

Medicine Name

Cornus officinalis S, et Z (Cornaceae) Fruit

Outpost of Eclipta prostrata (Compositae)

Fruit of mulberry alba (Moraceae)

Roots of Sanguisorba officinalis L. (Rosaceae)

Fruit of Achyranthes japonica Nakai (Amarantaceae)

Carcelium abrotanoides, fruit of L. (Carduaceae)

Seeds of Salvia miltiorrhiza Bunge (Lamiaceae)

Seed of Tosaza Cuscuta australis R. Br (Convolvulaceae)

Seed of Prunus persica Stokes (Rosaceae)

Black bean Glycine max Merr. Fruit of the (Glycine semen)

As a method of extracting the herbal extract of the present invention, it is possible to use a known method. For example, each herbal medicine is dried by any method of natural drying or forced drying, and finely chopped, and then water, ethanol, butanol, acetone, etc. It is carried out using organic solvents such as various kinds of polar solvents, ethers, hexane, benzene, chloroform, ethyl acetate, various kinds of nonpolar solvents, mixed solvents of these or alkaline water, or vegetable oils such as soybean oil and sesame oil. Cold, percolation, or hot. The leaching treatment is about 12-96 hours for cold needle and percolation, and depending on the type and temperature of solvent used for warm needle, but suitable is 0.5-24 hours at a temperature close to the reflux temperature of the solvent. It is good to do the degree.

In particular, the extraction extract of the present invention is preferably a tincture, a liquid extract, an extract leached in the hydrous alcohol.

The action and effect of the components of the herbal materials used in the present invention are shown in the following table.

The herbal formulation of the present invention is suitable for each part of one or more of fat milk, hyssop, crane, earthworm, black bean, audi, doin, cornus milk, nasturtium, and two or more types of salvia, but the degree or condition of the disease or the subject of administration The formulation of each prescription can be increased or decreased by various factors such as constitution and age. Therefore, the formulation of the prescription may be any combination capable of effectively exhibiting the hair growth promoting effect, but in particular, each of these herbal drugs is preferably selected within the range of 1 to 3 parts.

The formulation is specific to the weight ratio of the herbal medicine itself, and may be used as it is when extracting the whole product by blending the herbal medicine, but when formulated with the extract extract or chemicals, it is good to select the prescription formulation in terms of the herbal medicine weight.

The hair growth promoting composition of the present invention is also suitable for the leaching solution or ethanol of the leaching solution as a diluent as a coating agent, but general herbal prescription preparations such as acupuncture, premises, tincture, extract, rheumatic extract, syrup, ointment, cream It can be used as an oral or external preparation such as a preparation.

The herbal prescription of the present invention may also be blended into hair cosmetics such as wool, hair tonic, hair lotion, hair cream, shampoo, rinse, etc. in a conventional manner to form a medicinal cosmetic. Such formulations may contain skin absorption promoting substances to increase the effectiveness of the herbal formulations. The dosage of these preparations varies depending on the patient's age, symptoms, and method of administration. However, in the case of external preparations, it is recommended to apply them 1-5 liters per day to 1-5 times per day and continue for 1 month or more.

On the other hand, the hair growth promoting composition of the present invention is suitable in the range that does not impair the main effect of the other prescription of the above-mentioned prescription may be added to other hair growth promoter in order to give a synergistic effect to the main effect. Such substances include vasodilators such as capronium chloride, vitamins such as calcium pantothenate, vitamin A acetate and pantothenyl alcohol, amino acids such as methionine and serine, anti-inflammatory agents such as diphenhydramine hydrochloride, and fungicides such as benzalkonium chloride. It may contain.

The following examples may be more detailed description of the present invention, the present invention is not limited only to the examples.

Example 1

After mixing 10 gm of Cornus oil, Nasturtium each and 5 gm of Audi, add 150 ml of 30% hydrous ethanol, and chill it for 48 hours at room temperature, and extract by heating at 60-70 ° C. using an extractor. To 100 ml of the extract. The extract was concentrated to dryness to obtain 4 g of dry extract. For pharmacological and clinical trials, a 30% functional ethanol solution containing 5% dry extract was used.

Example 2

10 gm of cornus oil, nasturtium herb and 5 gm of fat milk and hyssop were treated in the same manner as in Example 1 to obtain 5.1 gm of dry extract.

Example 3

10 gm of cornus, 10 g each of nasturtium and 5 gm of hyssop, crane, and earthenware were treated as in Example 1 to obtain 6 gm of dry extract.

Example 4

Each of 10 gm of cornus oil, nasturtium, sweet ginseng, and 5 gm of fat milk, black bean, and doin were treated as in Example 1 to obtain 9 gm of dry extract.

Example 5

10 gm of cornus oil, nasturtium each and 5 gm of Audi, fat milk, hyssop and hackle were treated as in Example 1 to obtain 13 gm of dry extract. In the case of Example 2-5, pharmacological experiments and clinical trials were prepared by using a 30% hydrous ethanol solution containing 5% dry extract as in Example 1.

[Test Example 1]

1) Hair growth effect test

The hair growth effect test was performed using black mice (C57BL / 6, male), 47-50 weeks old, to remove dorsal hair, and 100 microliters of test substance according to Examples 1 to 5 were applied daily from the next day. The length of hair and the extent of hair growth over time were compared by assigning scores according to the degree of restoration after hair removal. For comparison of hair growth, the natural growth state was observed without applying the test substance to the control group.

The results are shown in Tables 1 and 2 below, and FIG. 1 is a photograph of external morphological changes showing the hair growth process according to the test material application according to Example 5. FIG.

TABLE 1

Change test result of hair length

TABLE 2

Result of restoration test to normal hair after hair removal

TABLE 4

Dosage: 5g / kg, weight

Number of test animals: 10

Deaths: 0

Autopsy: No significant abnormalities observed

2) skin irritation test

In order to determine the degree of skin irritation with respect to the composition according to the present invention, a skin patch test was carried out on 12 subjects of the composition according to Example 5. Observation determined the skin reaction after 24 hours or 48 hours of patching. The test results are shown in Table 5 below.

TABLE 5

Summary: The sample showed a non-irritant response in human skin irritation tests.

From the above results, the composition according to the present invention is considered to be a safe material for living organisms without toxicity.

From the above test results, the present invention has a special effect in that it can provide a composition having excellent biosafety and remarkable hair growth promoting effect.

Claims (1)

A hair growth promoting composition, comprising an extract of cornus, nasturtium and audi.