CN109745257A - A kind of cosmetic formulations and preparation method thereof with acne-removing - Google Patents
A kind of cosmetic formulations and preparation method thereof with acne-removing Download PDFInfo
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- CN109745257A CN109745257A CN201711082817.8A CN201711082817A CN109745257A CN 109745257 A CN109745257 A CN 109745257A CN 201711082817 A CN201711082817 A CN 201711082817A CN 109745257 A CN109745257 A CN 109745257A
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Abstract
The embodiment of the present invention provides a kind of cosmetic formulations and preparation method thereof with acne-removing, is related to cosmetics beauty treatment fields, and the secretion for reducing sebocyte cell androgen is combined by inhibiting bacteria and diminishing inflammation, treats acne from the root.By percentage to the quality, the cosmetic formulations with acne-removing include at least: nutgall extractive 1-10% and lupulus extract 1-10%.
Description
Technical field
The present invention relates to cosmetics beauty treatment fields more particularly to a kind of cosmetic formulations and its preparation with acne-removing
Method.
Background technique
Acne is a kind of chronic inflammation of pilosebaceous follicle, is common in the youth of both sexes of adolescence.The prevalence of acne
There are more than 400,000,000 whelk patients in sex investigation discovery, China, and it is improper to be such as not treated in time or prevent and treat, and can leave scar refractory throughout one's life,
And influence life.
The pathogenic factor of acne is more, mainly with endocrine factors, pilosebaceous duct dyskeratosis and acne skin
Infective agent caused by microorganism is related.Based on acne mechanism of production and performance, principle of reatment mainly includes following side
Face: (1) inhibit and reduce the secretion of sebum；(2) adhesive for weakening horn cell, mitigates the narrow of infundibulum of hair follicle portion, makes skin
Rouge is smooth, unobstructed secretion；(3) anaerobic propionibacterium acnes are killed in suppression；(4) it controls inflammation, prevents hair follicle sebum glandular structure from being broken
It is bad, to reduce scar.
And current most of cosmetics for anti-acne, it is focused mostly in the inhibiting bacteria and diminishing inflammation stage at initial stage, i.e., was generated in acne
One stage of journey is treated, therefore skin acne can continue to recur.More seriously, when development acne to inflammation phase
When, which may have already appeared dermal lesions, at this point, diminishing inflammation even with Related product, also not can avoid skin
Skin forms scar, seriously affects skin beauty, to bring greatly life puzzlement and psychological burden to people.
To sum up, additive concentrates on generating inhibiting bacteria and diminishing inflammation effect the effect of existing acne-removing beauty product, not over adjustment skin
The secretion situation of hormone improves acne in skin sebocyte cell, does not solve the problems, such as in the root that acne generates.
Summary of the invention
The embodiment of the invention provides a kind of cosmetic formulations and preparation method thereof with acne-removing, are disappeared by antibacterial
Inflammation combines the secretion for reducing sebocyte cell androgen, treats acne from the root.
In order to achieve the above objectives, the embodiment of the present invention adopts the following technical scheme that
The embodiment of the present invention provides a kind of cosmetic formulations with acne-removing, by percentage to the quality, described to have anti-acne
The cosmetic formulations of effect include at least: nutgall extractive 1-10% and lupulus extract 1-10%.
Chinese gall is a kind of widely applied Chinese medicine material, and extract has effects that good antibacterial anti-inflammatory and convergence,
Inactivated and making the intracorporal plasm of microorganism and a variety of enzymic coagulations, thus play to a variety of fungies such as propionibacterium acnes and
The good killing effect of bacterium.
Flavones is rich in lupulus extract, hops flavones is a kind of important active constituent in hops, is had anti-
Viral, antimycotic, antitumor, anti-oxidant, inhibition bone resorption, estrogen-like action etc., are chiefly used in medical and edible field.
Further, its effect can be preferably played since described two functional components are dissolved in oil-phase component, so
Functional component is compounded with necessary emulsifiable cosmetics carrier, it is therefore, by percentage to the quality, described that there is anti-acne function
The cosmetic formulations of effect further include:
Shea butter 1-3%, dimethicone 2-5%, glycerol 0.5-2%, stearine 2-5%, oil with hydrogenated soybean 3-10%,
16-18 alcohol 1-3%, isopropyl myristate 3-8%, reed fragrant plant oil 5-15%, tocopherol acetate 1-8%, Phenoxyethanol 0.1-1%, with
And deionized water 20-79.4%.
The embodiment of the present invention also provides a kind of preparation method of cosmetic formulations with acne-removing, this method comprises:
(1) by percentage to the quality, oily phase raw material: shea butter 1-3%, dimethicone 2-5%, glycerol 0.5-2%, glycerol is taken
Stearate 2-5%, oil with hydrogenated soybean 3-10%, 16-18 alcohol 1-3%, isopropyl myristate 3-8%, nutgall extractive 1-
10%, lupulus extract 1-10%；
(2) by percentage to the quality, Aqueous Phase Raw Material is taken: Phenoxyethanol 0.1-1%, reed fragrant plant oil 5-15%；Deionized water 20-79.4%；
(3) the oily phase raw material is heated to 70-90 DEG C respectively, sterilized about 15-25 minutes；Aqueous Phase Raw Material is heated to 80-90
DEG C, it sterilizes about 15-25 minutes；And the oily phase raw material and the Aqueous Phase Raw Material are cooled to 75-80 DEG C；
(4) the oily phase raw material is slowly added in the Aqueous Phase Raw Material, is allowed to fully emulsified, continues to be slowly stirred, it is cooling
To 35-45 DEG C, tocopherol acetate 1-8% is added and stirs evenly.
Further, before execution (1), the method also includes:
The ethyl alcohol of 10 times of volumes will be added into its crushed material after the ground crushing of the Chinese gall of cleaning treatment, filled under room temperature
Divide stirring, stand 20-24 hours, ethyl alcohol is recycled in filtering；
Freeze-drying, freeze-dried powder cross 120 meshes, obtain nutgall extractive.
Further, before execution (1), the method also includes:
It will be filtered after the hops of cleaning treatment is smash slurry into juice, and hops concentrate be obtained after centrifugal concentrating, to concentration
The ethyl alcohol of 5 times of volumes is added in liquid, is sufficiently stirred under room temperature, stands 1-3 hours, ethyl alcohol is recycled in filtering；
Freeze-drying, freeze-dried powder cross 120 meshes, obtain lupulus extract.
Nutgall extractive has the effect of good inhibition propionibacterium acnes, controls inflammation, and lupulus extract can
To play the effect of antagonism androgen, so that inhibitory hormone is horizontal, the two, which combines, can fundamentally adjust skin generation acne
Condition, prevent its recurrence.
The embodiment of the present invention provides a kind of cosmetic formulations and preparation method thereof with acne-removing, with mass percent
Meter, the cosmetic formulations with acne-removing include at least: nutgall extractive 1-10% and lupulus extract 1-10%.
Compared to the prior art, the present invention uses lupulus extract and nutgall extractive to compound as anti-acne function for the first time
The additive of effect, while the crucial bacterium propionibacterium acnes for inhibiting inflammation and acne to occur, it is suppressed that sebocyte cell swashs
It is plain horizontal, the skin environment that acne generates is adjusted from acne genesis mechanism, not only plays therapeutic effect, moreover it is possible to prevent acne
Inflammation phase is developed to, the damage of skin area is inhibited to aggravate, reduces the probability that skin generates scar.
It is experimentally confirmed that compared using acne-removing additive of the invention with other acne-removing additives in the market,
Using the trier of additive of the present invention, pore and ferroheme are substantially reduced in other products after 72 hours, are illustrated of the invention
Acne-removing additive has better advantage in treatment acne.Raw material sources of the present invention are wide, at low cost, safely may be used
It leans on, manufacturing process is simple and easy, is suitble to industrialized production, has broad application prospects in daily skin protection cosmetics field.
Detailed description of the invention
Fig. 1 is the comparison diagram of the pore dia of A group subject provided in an embodiment of the present invention and B group subject；
Fig. 2 is the comparison diagram of the ferroheme of A group subject provided in an embodiment of the present invention and B group subject.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention is described in detail.
It should be noted that Multi-functional skin tester MC960 comes from Germany CK in example.
Embodiment 1
The embodiment of the present invention provides a kind of cosmetic formulations with acne-removing, by percentage to the quality, described to have anti-acne
The cosmetic formulations of effect include at least: nutgall extractive 1-10% and lupulus extract 1-10%.
Specifically, preparing a kind of anti-acne lotion in the present embodiment.
Including following components, by percentage to the quality, nutgall extractive 5%, lupulus extract 5%, shea butter 3%,
Dimethicone 2%, glycerol 2%, stearine 2%, oil with hydrogenated soybean 3%, 16-18 alcohol 1%, isopropyl myristate 3%, reed
Fragrant plant oil 5%, tocopherol acetate 8%, Phenoxyethanol 0.3%, deionized water 60.5%.
Anti-acne additive accounts for the 10% of skin care item vehicle weight.
Embodiment 2
The embodiment of the present invention provides a kind of cosmetic formulations with acne-removing, by percentage to the quality, described to have anti-acne
The cosmetic formulations of effect include at least: nutgall extractive 1-10% and lupulus extract 1-10%.
Specifically, preparing a kind of acne eliminating cream in the present embodiment.
Including following components, by percentage to the quality, nutgall extractive 1%, lupulus extract 10%；Shea butter
1%, dimethicone 5%, glycerol 0.5%, stearine 5%, oil with hydrogenated soybean 10%, 16-18 alcohol 1%, myristic acid isopropyl
Ester 5%, reed fragrant plant oil 5%, tocopherol acetate 8%, Phenoxyethanol 0.8%, deionized water 7.3%.
Anti-acne additive accounts for the 11% of skin care item vehicle weight.
Embodiment 3
Specifically, preparing a kind of anti-acne lotion in the present embodiment.
By in embodiment 1 nutgall extractive and lupulus extract with tea tree ethereal oil, (currently used anti-acne is made up
Effect raw material in product) it replaces, remaining ingredient keeps identical.
Including following components, by percentage to the quality, tea tree ethereal oil 10%, shea butter 3%, dimethicone 2%, glycerol
2%, stearine 2%, oil with hydrogenated soybean 3%, 16-18 alcohol 1%, isopropyl myristate 3%, reed fragrant plant oil 5%, tocopherol acetic acid
Ester 8%, Phenoxyethanol 0.5%, deionized water 60.5%.
The anti-acne lotion prepared in embodiment 1 and embodiment 3 is carried out to the influence test of acne and skin quality:
Tested crowd is acne skin, and tested crowd is divided into two groups of A, B, and every group of 15 people are ignorant to trial product, is excluded
Influence of the psychological factor to the product overall evaluation.1 product of embodiment is used in A group embodiment；Embodiment is used in B group comparative example
3 products.
After subject's face cleaning, a trial product is smeared respectively at the every 6h of acne spots, with CK skin detection instrument respectively at 0h,
6h, 12h, for 24 hours, 48h, 72h detect its acne spots ferroheme, pore two indices.
Acne spots ferroheme degree reacts the power of its inflammatory reaction, when acne spots ferroheme is high, shows the area
Inflammatory reaction is stronger, and when acne spots ferroheme is low, inflammatory reaction is weaker；Pore size can be as acne skin grease
The index of degree of strength is secreted, when fat secretion amount is big, pore dia be will increase, when fat secretion amount is small, pore dia
It can accordingly reduce.
As depicted in figs. 1 and 2, measurement result shows A group subject after using 12h, under ferroheme degree is compared with 0h
Drop 18, as time went on, embodiment subject's ferroheme degree persistently reduces, A group subject after 72h, pore dia and
After 0h, relative decrease 1.65；And B group subject ferroheme after using 72h is just decreased obviously, pore dia is in 72h
There is no significantly changing.
Subject shows that A group subject only has 1 people to think the irritating feeling of product used, and 13 people using feeling evaluation
Thinking skin lesion after 24h has reparation phenomenon, and has 6 people to think the irritating feeling of product used in B group subject, wherein 2 people recognize
There is reparation phenomenon after 24h for skin lesion.So anti-acne additive used is compared with anti-acne additive is often used in market in the present invention, thorn
Sharp property is smaller, and skin lesion resume speed is faster.
Illustrating anti-acne additive of the invention, fundamentally inhibiting bacteria and diminishing inflammation and reduction sebocyte cell hormone aspect treat Cuo
Sore, it is more more significant than the single effect for inhibition bacterial inflammation.
The embodiment of the present invention provides a kind of cosmetic formulations and preparation method thereof with acne-removing, with mass percent
Meter, the cosmetic formulations with acne-removing include at least: nutgall extractive 1-10% and lupulus extract 1-10%.
Compared to the prior art, the present invention uses lupulus extract and nutgall extractive to compound as anti-acne function for the first time
The additive of effect, while the crucial bacterium propionibacterium acnes for inhibiting inflammation and acne to occur, it is suppressed that sebocyte cell swashs
It is plain horizontal, the skin environment that acne generates is adjusted from acne genesis mechanism, not only plays therapeutic effect, moreover it is possible to prevent acne
Inflammation phase is developed to, the damage of skin area is inhibited to aggravate, reduces the probability that skin generates scar.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (5)
1. a kind of cosmetic formulations with acne-removing, which is characterized in that by percentage to the quality, described that there is acne-removing
Cosmetic formulations include at least: nutgall extractive 1-10% and lupulus extract 1-10%.
2. the cosmetic formulations according to claim 1 with acne-removing, which is characterized in that by percentage to the quality,
The cosmetic formulations with acne-removing further include:
Shea butter 1-3%, dimethicone 2-5%, glycerol 0.5-2%, stearine 2-5%, oil with hydrogenated soybean 3-10%,
16-18 alcohol 1-3%, isopropyl myristate 3-8%, reed fragrant plant oil 5-15%, tocopherol acetate 1-8%, Phenoxyethanol 0.1-1%, with
And deionized water 20-79.4%.
3. a kind of preparation method of the cosmetic formulations with acne-removing, which is characterized in that the change with acne-removing
The preparation method of cosmetic preparation includes:
(1) by percentage to the quality, oily phase raw material: shea butter 1-3%, dimethicone 2-5%, glycerol 0.5-2%, glycerol is taken
Stearate 2-5%, oil with hydrogenated soybean 3-10%, 16-18 alcohol 1-3%, isopropyl myristate 3-8%, nutgall extractive 1-
10%, lupulus extract 1-10%；
(2) by percentage to the quality, Aqueous Phase Raw Material is taken: Phenoxyethanol 0.1-1%, reed fragrant plant oil 5-15%；Deionized water 20-79.4%；
(3) the oily phase raw material is heated to 70-90 DEG C respectively, sterilized about 15-25 minutes；Aqueous Phase Raw Material is heated to 80-90
DEG C, it sterilizes about 15-25 minutes；And the oily phase raw material and the Aqueous Phase Raw Material are cooled to 75-80 DEG C；
(4) the oily phase raw material is slowly added in the Aqueous Phase Raw Material, is allowed to fully emulsified, continues to be slowly stirred, it is cooling
To 35-45 DEG C, tocopherol acetate 1-8% is added and stirs evenly.
4. the preparation method of the cosmetic formulations according to claim 3 with acne-removing, which is characterized in that executing
(1) before, the method also includes:
The ethyl alcohol of 10 times of volumes will be added into its crushed material after the ground crushing of the Chinese gall of cleaning treatment, filled under room temperature
Divide stirring, stand 20-24 hours, ethyl alcohol is recycled in filtering；
Freeze-drying, freeze-dried powder cross 120 meshes, obtain nutgall extractive.
5. the preparation method of the cosmetic formulations according to claim 3 with acne-removing, which is characterized in that executing
(1) before, the method also includes:
It will be filtered after the hops of cleaning treatment is smash slurry into juice, and hops concentrate be obtained after centrifugal concentrating, to concentration
The ethyl alcohol of 5 times of volumes is added in liquid, is sufficiently stirred under room temperature, stands 1-3 hours, ethyl alcohol is recycled in filtering；
Freeze-drying, freeze-dried powder cross 120 meshes, obtain lupulus extract.
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| CN201711082817.8A CN109745257A (en) | 2017-11-07 | 2017-11-07 | A kind of cosmetic formulations and preparation method thereof with acne-removing |
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| CN201711082817.8A CN109745257A (en) | 2017-11-07 | 2017-11-07 | A kind of cosmetic formulations and preparation method thereof with acne-removing |
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| CN110840805A (en) * | 2019-12-04 | 2020-02-28 | 泉后(广州)生物科技研究院有限公司 | Acne removing composition and cosmetic |
| CN111281851A (en) * | 2019-12-10 | 2020-06-16 | 程定义 | PH-targeted flexible nanoliposome with acne removing effect and preparation method thereof |
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Effective date of registration: 20200312 Address after: 710024 floor 4, building B1, standard workshop community, No. 599, Fangyuan Third Road, modern textile industrial park, Baqiao District, Xi'an City, Shaanxi Province Applicant after: Xi'an Bohong Biotechnology Co.,Ltd. Address before: 710024 B1 3-4 layer of standard workshop District of Baqiao District Textile Industrial Park, Xi'an City, Shaanxi Applicant before: SHAANXI BIOHONG BIOTECHNOLOGY GROUP CO.,LTD. |
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Application publication date: 20190514 |