CN103202796A - Skin care composition and face cream with acne treatment efficacy and preparation method of face cream - Google Patents
Skin care composition and face cream with acne treatment efficacy and preparation method of face cream Download PDFInfo
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Abstract
The invention provides a face cream with acne treatment efficacy and a preparation method of the face cream. The face cream is prepared by taking traditional Chinese medicine theory of China as a basis, taking skin health as a purpose, taking a composite traditional Chinese medicine extract as a main efficacy additive and taking common substrate components in cosmetics as assist. The acne treatment face cream provided by the invention has bacteriostasis efficacy, and also has the efficacies of removing pathogenic heat from blood, promoting blood, reducing the stagnation, relieving itching, diminishing inflammation and the like. The composite traditional Chinese medicine extract is naturally green, healthy and safe, and can be widely applied to acne treatment cosmetics.
Description
Technical field
The present invention relates to a kind of skin care compositions, specifically a kind of have anti-acne and have the Chinese medicine composition of bacteriostasis efficacy concurrently and the Chinese medicine skin protection facial cream that is prepared by this skin care compositions.
Background technology
Comedo is that hair follicle and sebaceous gland are blocked, and a kind of chronic inflammatory disease dermatoses that inflammation causes is common in the youth of both sexes of adolescence, mainly occur in face, cervical region, chest and back, shoulder and upper arm, form pimple, the traditional Chinese medical science claims " acne ", and the doctor trained in Western medicine name of disease is " acne ".The adolescence androgen increases, and smegma increases, and makes hair follicle, the different hyperkeratosis of sebaceous gland simultaneously, and the flat dead cell that horny layer comes off falls the hair follicle infundibulum, is combined with sebum, produces mixture.If these mixture can not freely be discharged skin surface, in hair follicle, form the fat bolt and deposit.When these dyskeratosis cell aggregationes, when expanding, lower hopper just forms ripe acne.The bacterial decomposition that sebum is existed in the hair follicle produces fatty acid, and latter's hair follicle stimulating causes inflammation, and causes the follicular wall damage to be broken, and the hair follicle content enters corium, thereby, cause the hair follicle inflammatory reaction of varying degree on every side.The genesis mechanism of comedo, relevant with following three big factors:
(1) to the agnogenio property aggravation of androgen steroid (as testosterone, dehydroepiandros-sterone, hydroxyprogesterone) reaction, causes sebum to produce and increase.
(2) propionibacterium acnes hypertrophy.This bacterium is formed for the hair follicle normal flora, and it is its effect machine matter with sebum, and makes it partly to be converted into free fatty.But propionibacterium acnes is the activating complement path also, produces two kinds of chemotactic factors at least, impels inflammation to take place.
(3) the capsular epithelium cell quantity increases, and tackness is arranged, and it is excessive to form the hair follicle tetention keratosis.Latter's occurrence cause is undistinct yet.Propionibacterium acnes produces free fatty, may be the principal element that comedo forms.
At present there is following problem in popular product for resolving poxes on the market: 1, easily cause skin allergy, and big to skin irritation; 2, add chemical antibacterial and destroy the skin normal flora; 3, add hormones such as some banned substances such as chloromycetin; 4, add heavy metal substance.
Summary of the invention
The objective of the invention is to propose a kind of skin care compositions with acne-removing.
A further object of the present invention is to propose a kind of preparation method of above-mentioned skin care compositions.
The 3rd purpose of the present invention is to propose the skin protection facial cream that utilizes above-mentioned preparation method to prepare.
Invention thinking of the present invention is:
The present invention utilizes advanced biotechnology, in conjunction with the traditional theory of Chinese medical science of China, Herba Artemisiae Scopariae, the Fructus Kochiae, Cortex Moutan, Galla Chinensis, Spina Gleditsiae, Spica Prunellae are effectively combined, form compound preparation, and with it as active component, be prepared into Pimple removing scream, make it have antibiotic, short infiltration, the effect of heat-clearing and toxic substances removing, promoting blood circulation and detumescence, thus can effectively prevent and treat dissimilar acnes, give the new life of skin and vigor.
For realizing purpose of the present invention, the present invention adopts following concrete technical scheme:
A kind of skin care compositions with acne-removing, described skin care compositions comprise A mutually with B mutually, described A is made up of following weight percentages:
Described B is made up of following materials by weight percentage:
Above-mentioned a kind of skin care compositions with acne-removing, wherein said Chinese medicine extract are extracted through the conventional extracting method of the field of Chinese medicines by following raw materials in weight portion medicine and obtain:
Herba Artemisiae Scopariae 20～30, the Fructus Kochiae 20～30, Cortex Moutan 10～20, Galla Chinensis 10～20, Spina Gleditsiae 10～20, Spica Prunellae 10～20.
Preferably, above-mentioned skin care compositions, wherein said Chinese medicine extract are extracted through following method by following raw materials in weight portion medicine and obtain:
Herba Artemisiae Scopariae 20～30, the Fructus Kochiae 20～30, Cortex Moutan 10～20, Galla Chinensis 10～20, Spina Gleditsiae 10～20, Spica Prunellae 10～20;
Described method is that step is as follows:
(1) according to above-mentioned weight portion proportioning weighting raw materials;
(2) percent by volume is 75%～80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10～1:20, and 60 ℃～70 ℃ heated and stirred 1～2 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10～1:20,60 ℃～70 ℃ of heated and stirred 30min～60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time are concentrated into 0.2～0.5g/ml for the first time, get concentrate;
(3) according to adding propylene glycol or butanediol in the mass ratio concentrate that to be 1:1～1:2 obtain to step (2), sucking filtration, 3000～5000 rev/mins of centrifuging and taking supernatant, namely.
Above-mentioned a kind of skin care compositions with acne-removing, wherein, described compositions also comprises the C phase, described C is antiseptic 0.05～0.2wt% mutually.
A kind of preparation method of above-mentioned skin care compositions, described method comprises the steps:
(1) B phase: butanediol and HANSHENGJIAO are stirred, stand-by; B except Chinese medicine extract other raw materials mutually is added to the water, and the back that stirs adds butanediol HANSHENGJIAO mixture, heats 80～85 ℃, mixing;
(2) A phase: according to each raw material of ratio requirement weighing A phase, heat 80～85 ℃, mixing;
(3) A is all joined mutually B mutually in, 2000～3000 rev/mins, homogenizing 5min～10min; 30～50 rev/mins, behind stirring 5～10min, begin to stir cooling, 30～50 rev/mins of speed, rate of temperature fall is 1～2 ℃/minute;
(4) when temperature drops to below 45～50 ℃, add Chinese medicine extract, stir, continue to be cooled to below 40 ℃, namely.
A kind of above-mentioned skin protection preparation of compositions method processed, wherein, described method comprises the steps:
(1) B phase: butanediol and HANSHENGJIAO are stirred, stand-by; B except Chinese medicine extract other raw materials mutually is added to the water, and the back that stirs adds butanediol HANSHENGJIAO mixture, heats 80～85 ℃, mixing;
(2) A phase: according to each raw material of ratio requirement weighing A phase, heat 80～85 ℃, mixing;
(3) A is all joined mutually B mutually in, 2000～3000 rev/mins, homogenizing 5min～10min; 30～50 rev/mins, behind stirring 5～10min, begin to stir cooling, 30～50 rev/mins of speed, rate of temperature fall is 1～2 ℃/minute;
(4) for when temperature drops to below 45～50 ℃, adding Chinese medicine extract and C be antiseptic mutually, stirs, and continues to be cooled to below 40 ℃, namely.
A kind of skin care formulation with acne-removing, described skin care formulation is made by said method.
The preparation that above-mentioned raw materials and method prepare is Pimple removing scream.According to use approach difference, Chinese medicine composition of the present invention is made powder after can simply pulverizing, and pats skin, also can realize final technique effect.Also can make other external-use skin care preparations as additive through extracting, as cleansing milk, spray or essence etc.But be not limited to above-mentioned dosage form.
Facial cream of the present invention recommends using method to be: after clean of every day, Pimple removing scream is coated on the skin of pox, massage treats that facial cream slowly absorbs gently.
Useful result of the present invention:
Raw material of the present invention is all selected natural plant composition for use, and is non-stimulated to skin safe through experiment confirm, can fundamentally improve the skin microenvironment and reach the effect of curing acne, and have clearing away heat and cooling blood concurrently, blood circulation promoting and dispersing pathogen accumulation, antipruritic, press down effects such as fat antiinflammatory, can also alleviate and eliminate cicatrix pockmark etc.Raw material of the present invention obtains easily, preparation method is easy, green safety, and anti-acne is effective, is easy to be accepted by consumers in general, has good application prospects and market prospect.
Description of drawings
Fig. 1 Pimple removing scream sample uses back skin oil and fat changes of contents situation;
Fig. 2 Pimple removing scream sample uses the situation of change of back skin oil and fat increment rate;
Fig. 3 Pimple removing scream sample uses the relative increment rate of back skin oil and fat;
Fig. 4 Pimple removing scream is to the inhibition of pimple;
Fig. 5 Pimple removing scream is to the inhibition of pustule;
Fig. 6 first all volunteer's in-service evaluation effects;
Fig. 7 second all volunteer's in-service evaluation effects;
Fig. 8 the 3rd all volunteer's in-service evaluation effects;
Volunteer's in-service evaluation effect around Fig. 9 the;
The back volunteer produced evaluation of effect to preventing pockmark around Figure 10 Pimple removing scream used.
The specific embodiment
The used medical material of present embodiment all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.Other raw materials all can obtain by commercially available purchase, and the present invention uses the source of raw material to see Table 1.
Table 1
The preparation of embodiment 1 facial cream of the present invention
Raw material and proportioning (mass percent) see Table 2:
Table 2
The preparation of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 30g, Fructus Kochiae 20g, Cortex Moutan 10g, Galla Chinensis 20g, Spina Gleditsiae 10g, Spica Prunellae 20g.
(2) percent by volume is 75% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10, and 60 ℃ of heated and stirred 1 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10,60 ℃ of heated and stirred 30min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.2g/ml, gets concentrate;
(3) redissolve according to adding propylene glycol in the mass ratio concentrate that to be 1:2 obtain to step (2), sucking filtration, 3000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
The facial cream preparation method:
(1) B phase: butanediol and HANSHENGJIAO are stirred, stand-by; B except Chinese medicine prescription extracting solution other raw materials mutually is added to the water, and the back that stirs adds butanediol HANSHENGJIAO mixture, heats 80 ℃;
(2) A phase: according to ratio requirement weighing A phase raw material, heat 85 ℃;
(3) A is all joined mutually B mutually in, 2000 rev/mins, homogenizing 5min; 30 rev/mins, behind the stirring 5min, begin to stir cooling, 30 rev/mins of speed, rate of temperature fall is 1 ℃/minute;
(4) when temperature drops to below 45 ℃, add Chinese medicine extract, stir; When temperature drops to below 40 ℃, get final product described facial cream.
The preparation of embodiment 2 facial creams of the present invention
Raw material and proportioning (mass percent) see Table 3:
Table 3
The preparation method of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 20g, Fructus Kochiae 30g, Cortex Moutan 20g, Galla Chinensis 10g, Spina Gleditsiae 15g, Spica Prunellae 15g.
(2) percent by volume is 80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:20, and 70 ℃ of heated and stirred 2 hours are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:20,70 ℃ of heated and stirred 60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.3g/ml, gets concentrate;
(3) according to adding butanediol in the mass ratio concentrate that to be 1:1 obtain to step (2), sucking filtration, 5000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
The preparation method of facial cream:
(1) B phase: butanediol and HANSHENGJIAO are stirred, stand-by; B except Chinese medicine prescription extracting solution other raw materials mutually is added to the water, and the back that stirs adds butanediol HANSHENGJIAO mixture, heats 85 ℃;
(2) A phase: according to ratio requirement weighing A phase raw material, heat 80 ℃;
(3) A is all joined mutually B mutually in, 3000 rev/mins, homogenizing 10min; 50 rev/mins, behind the stirring 10min, begin to stir cooling, 50 rev/mins of speed, rate of temperature fall is 2 ℃/minute;
(4) when temperature drops to below 50 ℃, add the Chinese prescription extracting solution, stir; When temperature drops to below 40 ℃, namely.
The preparation of embodiment 3 facial creams of the present invention
Raw material and proportioning (mass percent) see Table 4:
Table 4
The Chinese medicine extract preparation method:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 25g, Fructus Kochiae 25g, Cortex Moutan 15g, Galla Chinensis 15g, Spina Gleditsiae 20g, Spica Prunellae 10g.
(2) percent by volume is 75% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:15, and 65 ℃ of heated and stirred 1.5 hours are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:15,65 ℃ of heated and stirred 40min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.5g/ml, gets concentrate;
(3) according to adding butanediol in the mass ratio concentrate that to be 1:1 obtain to step (2), sucking filtration, 5000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
The facial cream preparation method:
(1) B phase: butanediol and HANSHENGJIAO are stirred, stand-by; B except Chinese medicine prescription extracting solution other raw materials mutually is added to the water, and the back that stirs adds butanediol HANSHENGJIAO mixture, heats 85 ℃;
(2) A phase: according to ratio requirement weighing A phase raw material, heat 80 ℃;
(3) A is all joined mutually B mutually in, 2500 rev/mins, homogenizing 8min; 40 rev/mins, behind the stirring 8min, begin to stir cooling, 40 rev/mins of speed, rate of temperature fall is 1 ℃/minute;
(4) when temperature drops to below 48 ℃, add Chinese prescription extracting solution and C raw material mutually, stir; When temperature drops to below 40 ℃, namely.
The preparation of embodiment 4 facial creams of the present invention
Raw material and proportioning (mass percent) see Table 5:
Table 5
The preparation of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 20g, Fructus Kochiae 20g, Cortex Moutan 10g, Galla Chinensis 10g, Spina Gleditsiae 20g, Spica Prunellae 10g.
(2) percent by volume is 75% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:20, and 60 ℃ of heated and stirred 1 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:20,60 ℃ of heated and stirred 30min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.4g/ml, gets concentrate;
(3) according to adding butanediol in the mass ratio concentrate that to be 1:1 obtain to step (2), sucking filtration, 5000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
The facial cream preparation method:
(1) B phase: butanediol and HANSHENGJIAO are stirred, stand-by; B except Chinese medicine prescription extracting solution other raw materials mutually is added to the water, and the back that stirs adds butanediol HANSHENGJIAO mixture, heats 83 ℃;
(2) A phase: according to ratio requirement weighing A phase raw material, heat 83 ℃;
(3) A is all joined mutually B mutually in, 3000 rev/mins, homogenizing 5min; 50 rev/mins, behind the stirring 5min, begin to stir cooling, 50 rev/mins of speed, rate of temperature fall is 1～2 ℃/minute;
(4) when temperature drops to below 50 ℃, add Chinese prescription extracting solution and C raw material mutually, stir; When temperature drops to below 40 ℃, namely.
Effect experiment of the present invention
One, Pimple removing scream anti-acne effect
1. inhibition zone
1) experimental principle
On inoculating for examination culture of strains base, impose quantitative embodiment 1 preparation sample, utilize the scattering and permeating effect of sample in agar culture medium, reach certain limit through sample infiltration diffusion behind the certain hour.In the scope that Mlc reaches, the growth of indicator bacteria just is suppressed, and produces an aseptic transparent region, is called inhibition zone.Under certain condition with certain limit in, the diameter of inhibition zone and the logarithm of sample concentration be functional relationship linearly.Utilize this principle, can compare the size of antibacterial virulence, or the working sample content of effective.The inhibition zone size of parallel 1, parallel 2, parallel 3 representative samples, one group of experimental data will be done three parallel laboratory tests, and last experimental result is to get the meansigma methods of three parallel numerical value as last result.
2) the inhibition zone result of external bacteriostatic experiment
Table 6
The criterion of external antibacterial qualitative results: antibacterial circle diameter is insensitive (-) less than 8mm, and 8～13mm is low responsive (+), and 13～19mm is medium sensitivity (++), and 19mm is above to be extremely sensitive (+++).The embodiment of the invention 1 preparation Chinese medicine extract has good fungistatic effect, and the inventor utilizes other embodiment to prepare sample and repeats above-mentioned experiment, and the result is with embodiment 1.
2, product control oil effect
1) experimental principle
Human experimentation, the crowd forms test population by particular experiment, test subject makes the variation of the skin oil and fat content before and after (and cosmetic industry composition) of applying some make up, thus determine cosmetics (or functional component) press down the fat effect.
2) experimental apparatus and sample
Experimental apparatus: skin oil and fat tester
SM815.
The facial cream of sample: embodiment 1 preparation.
Blank: as to be tried the position and do not use any cosmetics.
3) experiment crowd
The experimenter amounts to 30 people.Concrete sex composition and age structure are determined at random.If there are 2 people untoward reaction to occur, then stop test during this time; The result does not find untoward reaction.
4) experimental technique
(1) selects experimenter's forehead (branch left and right sides two parts) cycle labeling successively: tried region samples group and blank zone;
(2) technical staff uses the skin oil and fat tester
Averaging in SM815 test test position 3～5 times, is designated as initial value.
(3) test the position the experimenter and smear sample (Pimple removing scream).
(4) experimenter make continuously applied some make up one hour, two hours, four hours after, use the skin oil and fat tester by the technical staff
SM815 measures 3～5 times, averages.
(5) add up the numerical value that records, analyze its skin oil and fat changes of contents rule.
5) interpretation of result
Fat content changes
The fat content variation is reflected in test period Experimental Area fat content change with time.Its value is more big, and fat content is more big, otherwise fat content is more little.
As shown in Figure 1, sample sets is compared with the blank group after using 1 hour, and diversity is obvious; Sample used in 4 hours, and the fat content of sample sets is starkly lower than blank group.
The oils and fats increment rate changes
Oils and fats increment rate=(sample sets fat content-initial fat content)/initial fat content
As shown in Figure 2, in test period, tried the position after sample uses 1 hour, compare with initial value, skin oil and fat secretion increment rate is starkly lower than blank group, and is lower than blank group always.
Press down the fat rate
The relative increment rate of oils and fats namely presses down fat rate=(sample sets fat content-blank group fat content)/blank group fat content; This value is more little, and it is more obvious to illustrate that the relative blank sample of test specimen presses down the fat effect.
As shown in Figure 3, in test period, tried after the position uses sample, it presses down the fat rate is negative value always.
6) conclusion
After using sample, the fat secretion amount of being tried the position be starkly lower than do not smear sample be subjected to illustrate that product has the ability that skin oil and fat is secreted that suppresses in the examination zone.The inventor utilizes other embodiment to prepare facial cream and repeats above-mentioned experiment, and the result is with embodiment 1.
3, prevent that pockmark from telling on
1) experimental principle
Pockmark a kind of reparation reaction that to be body produce tissue injury, when the damage of skin reaches corium or large-area skin blemish deeply, the epidermis at this position can not be regenerated, will be by the corium fabric cell, collagen and proliferation of vessels replace, and pockmark so just occurred.The pox scar is because the extruding of infection inflammation or external force forms, and the inflammatory response of Skin Cell has caused the destruction of skin histology and to injure the collagen protein of corium too many, has caused the generation of cicatrix.Therefore improve the skin environment, keep skin elasticity, guarantee that collagen protein not by excessive degradation, can reduce the generation of cicatrix.
(Matrix Metalloproteinases1 MMP-1) is the key enzyme of degrade collagen albumen to matrix metalloproteinase 1, and the activity that suppresses MMP-1 can effectively reduce the collagen protein amount that is degraded, thereby reduces the generation of cicatrix.Therefore the effect that cicatrix is produced of the active reaction plant functional component by vitro inhibition matrix metalloproteinase-1(MMP-1).
Set up MMP-1 enzyme reaction experiment porch, based on this platform, under the prerequisite of destructive enzyme reaction system not, add the plant extract functional component, detect the variation of product fluorescence intensity by the enzyme reaction system, the variation of reflection enzyme activity indirectly, thus reflect that this plant extraction liquid functional component is to the influence of MMP-1 activity.
2) experimental procedure
1. solvent preparation:
(1) preparation buffer (50mmol/L HEPES, 0.12mol/L NaCl, 10mmol/L CaCl2,20 μ mol/L ZnSO4,0.05%Brij-35, pH=7.5),
(2) the MMP-1 proenzyme is standby with buffer gradient dilution to 0.22 μ g/100 μ L;
(3) fluorogenic substrate DQ-gelatin is standby with buffer gradient dilution to 0.20 μ g/100 μ L;
(4) the zymoexcitator APMA of adding 30mmol in the 0.1mol/L of 1L NaOH solution, it is standby to form APMA storing solution (30mmol/L);
(5) embodiment 1 preparation sample ligand is made certain density solution for standby;
2.MMP-1 the activation of proenzyme: the volume ratio (MMP:APMA) of MMP-1 proenzyme solution (0.22 μ g/100 μ L) and APMA solution (30mmol/L) being pressed 10:1 is mixed, and hatches the 45min activation at 37 ° of C;
3. application of sample: MMP-1 solution (concentration has been reduced to 0.20 μ g/100 μ L) the 40 μ L that get after the activation add in the 96 hole ELISA Plate, add embodiment 1 preparation Chinese medicine extract 8 μ L again, fluorogenic substrate DQ-gelatin solution (0.20 μ g/100 μ L) 52 μ L, making the end reaction system is 100 μ L;
Table 7 vitro inhibition MMP-1 experiment application of sample table
4. constant temperature is hatched: the 96 hole ELISA Plate that will finish application of sample are put into 37 ℃ of incubator constant temperature and are hatched 600s;
5. experimental result detects
(1). be 460nm in excitation wavelength before the reaction, emission wavelength is to detect the fluorescence intensity for the treatment of the measuring plants functional component under the testing conditions of 520nm;
(2). detect the fluorescence intensity of whole reaction system after reaction system stops to hatch immediately with Bio-Red FLx-800 fluorescence microplate reader, excitation wavelength is 460nm, and emission wavelength is 520nm.
6. Data Processing in Experiment
MMP-1 suppresses percent (%)=[1-(A1-A2)/Ao] * 100%
The fluorescence intensity of A1-representative sample inhibition group
The fluorescence intensity of A2-representative sample self
Ao-the represent fluorescence intensity of blank group
It is more remarkable to the active inhibition of MMP-1 to suppress this kind of plant functional component of the more big expression of percent.
3) experimental result
Chinese medicine extract is 98.32% to the maximum inhibition of MMP-1 after tested.It is identical that the inventor repeats above-mentioned experimental result with other embodiment preparing products.
Conclusion: Chinese medicine extract of the present invention has the pockmark of preventing generation and the desalination pockmark has positive effect.
4, the organoleptic indicator of anti-acne effect
Choose 100 volunteers, 13 years old-35 years old age, average 21.5 years old, each 50 of men and women.All there is skin lesion in face: pimple, pustule, pockmark.
Using method: after clean, the facial cream sample of getting an amount of embodiment 1 preparation spreads upon the affected part, is massaged into gently to absorb fully to get final product, and uses for 1 course for the treatment of continuously every day twice, and 4 weeks were a course for the treatment of.
The therapeutic evaluation standard:
Skin lesion counting * 100% before curative effect=(skin lesion counting before the treatment-treatment back skin lesion counting)/treatment
Produce effects: skin lesion disappears 60%～90%, sx;
Effectively: skin lesion disappears 20%～60%, doing well,improving;
Invalid: skin lesion disappears＜and 20%, clinical symptoms is not improved;
1) pimple
As shown in Figure 4, after sample used for first week, its action effect at pimple was obvious, and the effect persistence in 1～3 three week is good.
2) pustule
As shown in Figure 5, after sample used for 2 weeks, the action effect at pustule of sample was obvious, and lasting effect is arranged.
3) pockmark
As shown in figure 10, after sample used for 4 weeks, sample prevented that the generation action effect of pockmark is obvious.
4) conclusion
The volunteer is after being to use sample:
(1) from the vision index directly perceived of skin: pimple, pustule, pockmark are judged, the state that can significantly improve target skin of its sample sets, and the prolongation of the time of using with the volunteer, it improves effect and gradually is and increases progressively trend.
(2) shown in Fig. 6 to 9, from volunteer self sensation aspect, along with the increase of the time of using, its volunteer feels particularly evident, certain anti-acne is arranged, prevent the effect that pockmark produces, wherein by detecting last week, namely the volunteer around the feels that effective number reaches 93%.It is identical that the inventor repeats above-mentioned experimental result with other embodiment preparing products.
Claims (9)
1. the skin care compositions with acne-removing is characterized in that, described skin care compositions comprise A mutually with B mutually, described A is made up of following weight percentages:
Described B is made up of following materials by weight percentage:
2. a kind of skin care compositions with acne-removing according to claim 1 is characterized in that, described Chinese medicine extract is extracted through the conventional extracting method of the field of Chinese medicines by following raw materials in weight portion medicine and obtains:
Herba Artemisiae Scopariae 20～30, the Fructus Kochiae 20～30, Cortex Moutan 10～20, Galla Chinensis 10～20, Spina Gleditsiae 10～20, Spica Prunellae 10～20.
3. skin care compositions according to claim 1 is characterized in that, described Chinese medicine extract is extracted through following method by following raw materials in weight portion medicine and obtains:
Herba Artemisiae Scopariae 20～30, the Fructus Kochiae 20～30, Cortex Moutan 10～20, Galla Chinensis 10～20, Spina Gleditsiae 10～20, Spica Prunellae 10～20;
Described method is that step is as follows:
(1) according to above-mentioned weight portion proportioning weighting raw materials;
(2) percent by volume is 75%～80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10～1:20, and 60 ℃～70 ℃ heated and stirred 1～2 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10～1:20,60 ℃～70 ℃ of heated and stirred 30min～60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time are concentrated into 0.2～0.5g/ml for the first time, get concentrate;
(3) according to adding propylene glycol or butanediol in the mass ratio concentrate that to be 1:1～1:2 obtain to step (2), sucking filtration, 3000～5000 rev/mins of centrifuging and taking supernatant, namely.
4. according to claim 1,2 or 3 described a kind of skin care compositionss with acne-removing, it is characterized in that described compositions also comprises the C phase, described C is antiseptic 0.05～0.2wt% mutually.
5. the preparation method of a claim 1,2 or 3 described skin care compositionss is characterized in that described method comprises the steps:
(1) B phase: butanediol and HANSHENGJIAO are stirred, stand-by; B except Chinese medicine extract other raw materials mutually is added to the water, and the back that stirs adds butanediol HANSHENGJIAO mixture, heats 80～85 ℃, mixing;
(2) A phase: according to each raw material of ratio requirement weighing A phase, heat 80～85 ℃, mixing;
(3) A is all joined mutually B mutually in, 2000～3000 rev/mins, homogenizing 5min～10min; 30～50 rev/mins, behind stirring 5～10min, begin to stir cooling, 30～50 rev/mins of speed, rate of temperature fall is 1～2 ℃/minute;
(4) when temperature drops to below 45～50 ℃, add Chinese medicine extract, stir, continue to be cooled to below 40 ℃, namely.
6. the described skin protection of claim 4 a preparation of compositions method processed is characterized in that described method comprises the steps:
(1) B phase: butanediol and HANSHENGJIAO are stirred, stand-by; B except Chinese medicine extract other raw materials mutually is added to the water, and the back that stirs adds butanediol HANSHENGJIAO mixture, heats 80～85 ℃, mixing;
(2) A phase: according to each raw material of ratio requirement weighing A phase, heat 80～85 ℃, mixing;
(3) A is all joined mutually B mutually in, 2000～3000 rev/mins, homogenizing 5min～10min; 30～50 rev/mins, behind stirring 5～10min, begin to stir cooling, 30～50 rev/mins of speed, rate of temperature fall is 1～2 ℃/minute;
(4) for when temperature drops to below 45～50 ℃, adding Chinese medicine extract and C be antiseptic mutually, stirs, and continues to be cooled to below 40 ℃, namely.
7. the skin care formulation with acne-removing is characterized in that, described skin care formulation is made by the described method of claim 5.
8. the skin care formulation with acne-removing is characterized in that, described skin care formulation is made by the described method of claim 6.
9. according to claim 7 or 8 described skin care formulations with acne-removing, it is characterized in that described skin care formulation is facial cream.
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| CN111973524A (en) * | 2019-12-05 | 2020-11-24 | 上海遇鑫生物科技有限公司 | Refreshing facial cleanser containing saponin and preparation method of refreshing facial cleanser |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105919863A (en) * | 2016-05-30 | 2016-09-07 | 皖南医学院 | Acne removing and skin beautifying cream rich in extracts of natural ingredients and preparation method thereof |
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| CN106726987A (en) * | 2016-12-28 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of inhibiting bacteria and diminishing inflammation composition and its application |
| CN109745257A (en) * | 2017-11-07 | 2019-05-14 | 陕西博鸿生物科技集团有限公司 | A kind of cosmetic formulations and preparation method thereof with acne-removing |
| CN111973524A (en) * | 2019-12-05 | 2020-11-24 | 上海遇鑫生物科技有限公司 | Refreshing facial cleanser containing saponin and preparation method of refreshing facial cleanser |
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| CN103202796B (en) | 2015-02-04 |
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