CN113940896B - Anti-aging skin repair liquid containing vitamin A alcohol and preparation method thereof - Google Patents
Anti-aging skin repair liquid containing vitamin A alcohol and preparation method thereof Download PDFInfo
- Publication number
- CN113940896B CN113940896B CN202111387753.9A CN202111387753A CN113940896B CN 113940896 B CN113940896 B CN 113940896B CN 202111387753 A CN202111387753 A CN 202111387753A CN 113940896 B CN113940896 B CN 113940896B
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- China
- Prior art keywords
- vitamin
- extract
- liquid containing
- repair liquid
- deionized water
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 33
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Classifications
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention relates to the technical field of skin care products, and discloses an anti-aging skin repair liquid containing vitamin A alcohol and a preparation method thereof, wherein the skin repair liquid consists of 8-12% of propylene glycol, 12-18% of tannin mixture, 0.5-0.8% of sodium hyaluronate, 10-12% of vitamin A alcohol solution, 0.2-0.5% of phenoxyethanol, 0.1-0.3% of ethylhexyl glycerol and the balance of deionized water; the tannin mixture comprises flos Matricariae Chamomillae extract, herba Taraxaci rhizome/root extract, herba Violae extract, flos Malvae extract, flos Lonicerae extract, radix Paeoniae extract and Aloe vera leaf juice; the vitamin A alcohol solution comprises glycerol, polyglycerol-10 laurate, nicotinamide, 3-o-ethyl ascorbic acid, 1, 2-pentanediol, caprylic/capric triglyceride, tocopheryl acetate, 1, 3-propanediol, and hydroxy-pinacol retinol; the tannin mixture and the vitamin A alcohol synergistically activate the silk fibroin, relieve sensitive skin and delay skin aging.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to an anti-aging skin repair liquid containing vitamin A alcohol and a preparation method thereof.
Background
The sensitive skin is a high reaction state of skin under physiological or pathological conditions, mainly occurs on the face, and clinically presents subjective symptoms such as burning, stinging, itching, tightness and the like, along with symptoms such as erythema, scales, telangiectasia and the like when the skin is stimulated by physical, chemical, mental and other factors.
The lack of silk fibroin can lead to the entry of foreign allergens into the body through broken epidermal barriers and binding to antigen presenting cells leading to the development of atopic diseases. Thus, symptoms and signs of atopic dermatitis such as dry skin, rash, itching and the like appear.
Retinol is natural vitamin a, and retinol and its derivatives are commonly referred to as: a retinoid family comprising: retinoids, retinoic acid, retinyl esters, beta-carotene, etc., are the preferred ingredients for use on skin as antioxidant, anti-aging and acne treatment.
The retinol component contained in the skin care product in the prior art is easy to lose activity in air, light and heat, has poor stability, and has large usage amount of anti-sensitive anti-aging nutritional components and poor effect.
Disclosure of Invention
Based on the defects of the prior art, the invention provides the anti-aging skin repair liquid containing the vitamin A alcohol, which has good effect and high safety under the use level of the anti-sensitive anti-aging nutritional ingredients.
Another object of the present invention is to provide a method for preparing the anti-aging skin repair liquid containing tretinoin, so as to rapidly meet the market demand.
To achieve the purpose, the invention adopts the following technical scheme:
the anti-aging skin repair liquid containing vitamin A alcohol comprises, by weight, 8-12% of propylene glycol, 12-18% of a tannin mixture, 0.5-0.8% of sodium hyaluronate, 10-12% of a vitamin A alcohol solution, 0.2-0.5% of phenoxyethanol, 0.1-0.3% of ethylhexyl glycerol and the balance of water;
the tannin mixture comprises flos Matricariae Chamomillae extract, herba Taraxaci rhizome/root extract, herba Violae extract, flos Mali Pumilae extract, flos Lonicerae extract, radix Paeoniae extract and Aloe vera leaf juice;
the vitamin A alcohol solution comprises glycerol, polyglycerol-10 laurate, nicotinamide, 3-o-ethyl ascorbic acid, 1, 2-pentanediol, caprylic/capric triglyceride, tocopheryl acetate, 1, 3-propanediol, and hydroxy-pinacol retinol.
Specifically, the tannin mixture comprises 1% of chamomile extract, 1% of dandelion rhizome/root extract, 1% of viola yedoensis extract, 1% of malva sylvestris extract, 0.5% of honeysuckle extract, 1% of paeonia lactiflora root extract, 0.5% of aloe vera leaf juice and the balance of water according to weight percentage.
Specifically, the vitamin A alcohol solution comprises, by weight, 15% of glycerol, 8% of polyglycerol-10 laurate, 6% of nicotinamide, 6% of 3-o-ethyl ascorbic acid, 2.5% of 1, 2-pentanediol, 2.5% of caprylic/capric triglyceride, 2.5% of tocopheryl acetate, 2.5% of 1, 3-propanediol, 1.5% of hydroxy pinacolone retinoate and the balance of water.
Furthermore, the invention also provides a preparation method of the anti-aging skin repair liquid containing the vitamin A alcohol, which comprises the following steps:
s1) weighing 8-12% of propylene glycol, 12-18% of tannin mixture, 0.5-0.8% of sodium hyaluronate, 10-12% of vitamin A alcohol solution, 0.2-0.5% of phenoxyethanol, 0.1-0.3% of ethylhexyl glycerol and the balance of water according to weight percentage;
s2) heating part of deionized water, then adding sodium hyaluronate for soaking, and uniformly stirring to obtain sodium hyaluronate gel;
s3) adding propylene glycol, the vitamin A alcohol solution and the tannin mixture into the sodium hyaluronate gel, uniformly stirring by using a homogenizer, adding the rest deionized water, and cooling to obtain emulsion;
s4) adding phenoxyethanol and ethylhexyl glycerol into the emulsion, and stirring until the phenoxyethanol and the ethylhexyl glycerol are dissolved, thus obtaining the anti-aging skin repair liquid containing the vitamin A alcohol.
Preferably, the heated deionized water of step S2) and the deionized water of step S3) each account for 50% of the total amount of deionized water used.
Preferably, in step S2), the deionized water is heated to a temperature of 45-50 ℃.
Preferably, in step S2), the soaking time of the sodium hyaluronate is 2-2.5h.
Preferably, in the step S3), the stirring time of the homogenizer is 15-20min, and the homogenizing time is 3-5min.
Preferably, in step S3), the temperature of the cooling is 35-40 ℃; in the step S4), the stirring time is 3-5min.
The technical scheme of the invention has the beneficial effects that: the anti-aging skin repair liquid containing the vitamin A alcohol contains a tannin mixture and the vitamin A alcohol which are cooperated to activate the silk fibroin, so that sensitive skin is relieved, and skin aging is delayed.
Furthermore, the invention also provides a method for preparing the anti-aging skin repair liquid containing the vitamin A alcohol, the process is simple, and the prepared product has good skin absorbability and high transdermal rate.
Drawings
FIG. 1 is a graph of test results of example 1 of the present invention;
FIG. 2 is a graph of test results of example 2 of the present invention;
FIG. 3 is a graph showing the test results of example 31 of the present invention.
Description of the embodiments
In the description herein, reference to the term "embodiment," "example," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the invention, the scope of which is defined by the claims and their equivalents.
The technical scheme of the invention is further described below with reference to the specific embodiments.
The anti-aging skin repair liquid containing vitamin A alcohol comprises, by weight, 8-12% of propylene glycol, 12-18% of a tannin mixture, 0.5-0.8% of sodium hyaluronate, 10-12% of a vitamin A alcohol solution, 0.2-0.5% of phenoxyethanol, 0.1-0.3% of ethylhexyl glycerol and the balance of water;
the tannin mixture comprises flos Matricariae Chamomillae extract, herba Taraxaci rhizome/root extract, herba Violae extract, flos Mali Pumilae extract, flos Lonicerae extract and Aloe vera leaf juice;
the vitamin A alcohol solution comprises glycerol, polyglycerol-10 laurate, nicotinamide, 3-o-ethyl ascorbic acid, 1, 2-pentanediol, caprylic/capric triglyceride, tocopheryl acetate, 1, 3-propanediol, and hydroxy-pinacol retinol.
The vitamin A alcohol-containing anti-aging skin repair liquid adopts the components of the chamomile extract, the dandelion root and stem/root extract, the viola yedoensis extract, the mallow flower extract, the honeysuckle extract, the paeonia lactiflora root extract and the aloe vera leaf juice which are contained in the tannin mixture as the plant extracts with the most soothing effect, and the tannin mixture is fused with the strong locking moisture of the small molecular sodium hyaluronate to provide multiple in vitro barrier protection for sensitive skin. The hydroxy pinacolone retinoic acid ester contained in the vitamin A alcohol solution can resist oxidation and relieve skin, and the tannin mixture and the vitamin A alcohol are synergistic, so that the silk fibroin is activated, sensitive skin is relieved, and skin aging is delayed.
In addition, the vitamin A alcohol solution can improve the stability of the contained hydroxy pinacolone retinoic acid ester and promote skin absorption into an anti-aging target part; the hydroxy pinacolone retinoic acid ester can directly act without combination conversion with biological enzyme, and has the advantages of less irritation, higher use safety and better transdermal rate.
Sodium hyaluronate is also called sodium hyaluronate, is a substance inherent to skin, exogenous sodium hyaluronate is an endogenous supplement to skin, small-molecule sodium hyaluronate can penetrate into epidermis layers of the skin, and promote the supply of skin nutrition and the excretion of wastes, so that skin aging is prevented, the regeneration of epidermal cells is accelerated by promoting the proliferation and differentiation of epidermal cells, the healing of skin at a damaged part is promoted, meanwhile, the skin is also moisturized and lubricated, the sodium hyaluronate can improve the physiological condition of the skin, the environment is provided for the synthesis of dermal collagen and elastic fibers, and the supply of nutrient substances is enhanced.
Specifically, the tannin mixture comprises 1% of chamomile extract, 1% of dandelion rhizome/root extract, 1% of viola yedoensis extract, 1% of malva sylvestris extract, 0.5% of honeysuckle extract, 1% of paeonia lactiflora root extract, 0.5% of aloe vera leaf juice and the balance of water according to weight percentage.
The flos Matricariae Chamomillae extract can relieve sensitive skin.
The extract of root/stem of Taraxacum officinale has effect of preventing skin inflammation.
Viola yedoensis extract can relieve burning sensation of sensitive skin and eliminate inflammation.
The flos Lonicerae extract is used for regulating sebum secretion, relieving free radical injury caused by ultraviolet irradiation, and has antiaging and moisturizing effects.
The paeonia lactiflora root extract has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, promoting metabolism, improving immunity and improving facial roughness.
The aloe vera leaf juice contains plant active polypeptide and amino acid, has the effects of diminishing inflammation, relieving pain and repairing skin wound, can treat skin inflammation, and has good healing efficacy on acne, freckle, acne, scald, incised wound, mosquito bite and the like.
Specifically, the vitamin A alcohol solution comprises, by weight, 15% of glycerol, 8% of polyglycerol-10 laurate, 6% of nicotinamide, 6% of 3-o-ethyl ascorbic acid, 2.5% of 1, 2-pentanediol, 2.5% of caprylic/capric triglyceride, 2.5% of tocopheryl acetate, 2.5% of 1, 3-propanediol, 1.5% of hydroxy pinacolone retinoate and the balance of water.
Glycerol, polyglycerol-10 laurate, 1, 2-pentanediol 2.5% and 1, 3-propanediol are used for regulating skin hydration function, increasing skin moisture, and improving skin dryness.
Nicotinamide can alleviate and prevent the dullness, chloasma and skin resistance decrease caused by the premature aging of skin.
3-O-ethyl ascorbic acid and tocopheryl acetate can inhibit tyrosinase activity, and have antioxidant effect.
Caprylic/capric triglyceride contains palm oil or coconut oil derivatives, and can lubricate and soften rough skin.
Hydroxy pinacolone retinoic acid ester: a retinol derivative has effects in regulating metabolism of epidermis and horny layer, resisting aging, reducing sebum secretion, relieving skin pigment, preventing acne, whitening skin, and removing speckle. The powerful effect of retinol is ensured, and simultaneously the irritation is greatly reduced, so that the retinol can be used for resisting aging and preventing acne recurrence.
Furthermore, the invention also provides a preparation method of the anti-aging skin repair liquid containing the vitamin A alcohol, which comprises the following steps:
s1) weighing 8-12% of propylene glycol, 12-18% of tannin mixture, 0.5-0.8% of sodium hyaluronate, 10-12% of vitamin A alcohol solution, 0.2-0.5% of phenoxyethanol, 0.1-0.3% of ethylhexyl glycerol and the balance of water according to weight percentage;
s2) heating part of deionized water, then adding sodium hyaluronate for soaking, and uniformly stirring to obtain sodium hyaluronate gel;
s3) adding propylene glycol, the vitamin A alcohol solution and the tannin mixture into the sodium hyaluronate gel, uniformly stirring by using a homogenizer, adding the rest deionized water, and cooling to obtain emulsion;
s4) adding phenoxyethanol and ethylhexyl glycerol into the emulsion, and stirring until the phenoxyethanol and the ethylhexyl glycerol are dissolved, thus obtaining the anti-aging skin repair liquid containing the vitamin A alcohol.
The sodium hyaluronate forms gel through soaking, can be quickly absorbed by skin, lubricate the skin and promote the humidity of the skin, and the vitamin A alcohol solution and the tannin mixture which are subjected to homogenization treatment can promote the transdermal rate absorbed by the skin, so that the efficacy of the anti-aging skin repair liquid containing the vitamin A alcohol is improved.
The stability of the emulsion is improved by adding phenoxyethanol and ethylhexyl glycerol.
Preferably, the heated deionized water of step S2) and the deionized water of step S3) each account for 50% of the total amount of deionized water used.
50% of the deionized water is used for dissolving the sodium hyaluronate in the step S1), so that the rest deionized water can be used for cooling later, and the problem that the product concentration is low due to the fact that the dosage of the deionized water needs to be increased is avoided.
Preferably, in step S2), the deionized water is heated to a temperature of 45-50 ℃.
The water temperature of 45-50 ℃ is beneficial to improving the dissolution and water absorption speed of sodium hyaluronate, and if the temperature is too high above 60 ℃, sodium hyaluronate can be decomposed, so that the heated water temperature is not too high.
Preferably, in step S2), the soaking time of the sodium hyaluronate is 2-2.5h.
Soaking in water at 40-50deg.C for more than 2 hr to saturate sodium hyaluronate.
Preferably, in the step S3), the stirring time of the homogenizer is 15-20min, and the homogenizing time is 3-5min.
The nutrient components contained in the tannin mixture and the vitamin A alcohol solution can be made into fine particles by stirring for more than 15min and homogenizing for more than 3min by a homogenizer, so that the absorption rate of skin can be improved.
Preferably, in step S3), the temperature of the cooling is 35-40 ℃; in the step S4), the stirring time is 3-5min.
Cooling to 35-40deg.C, adding phenoxyethanol to reduce volatilization of phenoxyethanol as antiseptic, adding ethylhexyl glycerol as stabilizer of emulsion, and stirring for 3-5min to uniformly distribute stabilizer in emulsion.
Examples 1 to 3
1. The anti-aging skin repair liquids containing tretinoin of examples 1 to 3 were prepared and prepared in the raw material ratios listed in table 1, and the preparation steps were as follows:
s1) weighing 8-12% of propylene glycol, 12-18% of tannin mixture, 0.5-0.8% of sodium hyaluronate, 10-12% of vitamin A alcohol solution, 0.2-0.5% of phenoxyethanol, 0.1-0.3% of ethylhexyl glycerol and the balance of water according to weight percentage;
s2) heating half of deionized water to 45-50 ℃, then adding sodium hyaluronate, soaking for 2-2.5h, and uniformly stirring to obtain sodium hyaluronate gel;
s3) adding propylene glycol, the vitamin A alcohol solution and the tannin mixture into the sodium hyaluronate gel, uniformly stirring for 15-20min by using a homogenizer, homogenizing for 3-5min, adding the rest half of deionized water, and cooling to 35-40 ℃ to prepare emulsion;
s4) adding phenoxyethanol and ethylhexyl glycerol into the emulsion, and stirring for 3-5min until the mixture is dissolved, thus obtaining the anti-aging skin repair liquid containing vitamin A alcohol.
TABLE 1 raw material compositions of examples 1-3
2. The following in vitro experiments were carried out with the anti-aging skin repair liquid containing tretinoin prepared in example 1:
2.1 experimental method: haCaT-FLG-Luc cells (15X 10 cells/mL) were treated with the anti-aging skin repair solution containing vitamin A alcohol at a mass concentration of 0.1%, 0.5% and 4%, respectively, using 1mM calcium chloride as a positive control for 72 hours, and then luciferase activity in the corresponding cell lysates was measured, and the effect of activating silk fibroin promoters was expressed by double induction with the test results, as shown in FIG. 1.
2.2 As can be seen from the test results shown in FIG. 1, the activities of luciferase in the cell lysates of HaCaT-FLG-Luc cells (15×10 cells/mL) treated with the anti-aging skin repair liquid containing vitamin A alcohol at mass concentrations of 0.1%, 0.5% and 4% were 26%, 97% and 364%, respectively, which indicates that the vitamin A alcohol solution of the present invention can promote the expression of silk Fibroin (FILAGGRIN), decompose to form moisturizing factors, and improve the moisturizing property of skin and the integrity of sebum.
3. The following in vitro experiments were carried out with the anti-aging skin repair liquid containing tretinoin prepared in example 2:
3.1 The experimental method comprises the following steps: triplicate samples were cultured in 96-well microplates with 293-VR1 cells, the anti-aging skin repair solutions containing tretinoin at concentrations of 0%, 1% and 4% were added to the culture cell fluids of the three samples, respectively, and the culture was continued for 30 minutes, with 1. Mu.M capsaicin for 3 hours, 10. Mu.M capsicum Zhuo Ping for a positive control of TRPV-1 receptor, and the cell activity of each sample after 3 hours was detected with an IncuCyt living cell imaging analyzer, and the detection results are shown in FIG. 2.
3.2 from the test results shown in FIG. 2, it can be seen that: the cell viability of the test sample with the capsaicin concentration of 1 mu M and the capsaicin concentration of 4% is respectively improved by about 2 times and 3.5 times compared with that of the control sample with the capsaicin concentration of 1 mu M, which proves that the vitamin A alcohol solution can increase the antagonism capability of cells to TRPV1 receptors, reduce external stimulus and ease skin sensitivity.
It is worth noting that TRPV1 (transient receptor potential vanillic acid subtype 1 channel protein) is present in unmyelinated C-fibers and aδ fibers, mainly regulating the human perception of burning, pain and stinging. TRPV1 plays an important role in hyperalgesia caused by inflammation. When inflammation occurs, inflammatory factors bind to respective receptors on neurons, act on TRPV1 through respective intracellular signaling pathways, cause sensitization of central or peripheral nerves, and exhibit hyperalgesia.
4. The following rat skin penetration test was performed with the anti-aging skin repair liquid containing tretinoin prepared in example 3:
4.1 detection instrument: a percutaneous absorption tester;
4.2 test method: smearing the free rhodamine B aqueous solution display agent on a test part of the skin of the mouse; diluting the anti-aging skin repair liquid containing vitamin A alcohol prepared in the embodiment 3 into 10% aqueous solution to serve as a test sample, smearing the aqueous solution on the test part, and respectively detecting a blank sample and the test sample at 2h and 4h, wherein an image obtained by detection is shown in a figure 3;
4.3 from the image shown in fig. 3 it can be seen that: the free rhodamine B water solution is concentrated on the stratum corneum at 2h and 4h, and cannot effectively permeate the stratum corneum barrier; the rhodamine B marked 10% concentration test sample has penetrated the stratum corneum barrier in 2 hours, and the fluorescence intensity of the stratum corneum penetrated part of the 10% test sample in 4 hours is enhanced in detail, which shows that the active ingredients of the 10% test sample have penetrated into the deep skin layers, and the skin permeability experiment results show that the anti-aging skin repair liquid containing the vitamin A alcohol can effectively deliver the active substances to the deep skin tissues.
Examples 4 to 6
5. The formula of the essence water prepared by the anti-aging skin repair liquid containing vitamin A alcohol and prepared by the method in the embodiment 1 is shown in the table 2 below;
5.1, comparing the effect of the product of a certain brand of the commercial similar vitamin A alcohol with the effect of using the product of a consumer;
5.2 test protocol:
consumer number: 12 persons;
test part: the inner side of the front arm;
test time: 2h/4h/6h;
test instrument: soft/fx;
test environment: 22 ℃ and 58% of humidity;
the testing method comprises the following steps: the capacitance method is adopted, each group of 12 people is respectively smeared on the inner sides of the left and right front arms and then is detected, the skin moisture contents of 2h, 4h and 6h are detected, and the average value of the detection results of each group is shown in the table 3.
Table 2 formulations of the essence water of examples 4-6
TABLE 3 skin moisture detection results for examples 4-6 and commercially available products
From the above results of the test in table 3, it can be seen that the essence water containing 1.5%, 2.5% and 3% of the anti-aging skin repair liquid containing vitamin a alcohol has excellent moisture retention of not less than 43% after 6 hours, and the water content of the same commercial products after 6 hours is only 34%, which is remarkably reduced compared with the prior products.
In conclusion, the anti-aging skin repair liquid containing the vitamin A alcohol contains the tannin mixture and the vitamin A alcohol which cooperate to activate the silk fibroin, so that sensitive skin is relieved, and skin aging is delayed.
Furthermore, the invention also provides a method for preparing the anti-aging skin repair liquid containing the vitamin A alcohol, the process is simple, and the prepared anti-aging skin repair liquid containing the vitamin A alcohol has good skin absorption and high transdermal rate.
In the description of the present specification, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the invention, the scope of which is defined by the claims and their equivalents.
The technical principle of the present invention is described above in connection with the specific embodiments. These descriptions are meant only to illustrate the principles of the invention; and should not be construed as limiting the scope of the invention in any way. Based on the explanation herein; other embodiments of the present invention will occur to those skilled in the art without the need for inventive effort; all of which fall within the scope of the present invention.
Claims (7)
1. The anti-aging skin repair liquid containing vitamin A alcohol is characterized in that the raw materials consist of 8-12% of propylene glycol, 12-18% of tannin mixture, 0.5-0.8% of sodium hyaluronate, 10-12% of vitamin A alcohol solution, 0.2-0.5% of phenoxyethanol, 0.1-0.3% of ethylhexyl glycerol and the balance of deionized water according to weight percentage;
the tannin mixture consists of 1% of chamomile extract, 1% of dandelion rhizome/root extract, 1% of viola yedoensis extract, 1% of mallow flower extract, 0.5% of honeysuckle flower extract, 1% of paeonia lactiflora root extract, 0.5% of aloe vera leaf juice and the balance of deionized water;
the vitamin A alcohol solution consists of 15% of glycerin, 8% of polyglycerol-10 laurate, 6% of nicotinamide, 6% of 3-o-ethyl ascorbic acid, 2.5% of 1, 2-pentanediol, 2.5% of caprylic/capric triglyceride, 2.5% of tocopheryl acetate, 2.5% of 1, 3-propanediol, 1.5% of hydroxy pinacol retinol and the balance of deionized water.
2. The method for preparing the anti-aging skin repair liquid containing tretinoin according to claim 1, comprising the following steps:
s1) weighing 8-12% of propylene glycol, 12-18% of tannin mixture, 0.5-0.8% of sodium hyaluronate, 10-12% of vitamin A alcohol solution, 0.2-0.5% of phenoxyethanol, 0.1-0.3% of ethylhexyl glycerol and the balance of deionized water according to weight percentage;
s2) heating part of deionized water, then adding sodium hyaluronate for soaking, and uniformly stirring to obtain sodium hyaluronate gel;
s3) adding propylene glycol, the vitamin A alcohol solution and the tannin mixture into the sodium hyaluronate gel, uniformly stirring by using a homogenizer, adding the rest deionized water, and cooling to obtain emulsion;
s4) adding phenoxyethanol and ethylhexyl glycerol into the emulsion, and stirring until the phenoxyethanol and the ethylhexyl glycerol are dissolved, thus obtaining the anti-aging skin repair liquid containing the vitamin A alcohol.
3. The method for preparing an anti-aging skin repair liquid containing tretinoin according to claim 2, wherein the heated deionized water of step S2) and the deionized water of step S3) each account for 50% of the total amount of deionized water used.
4. The method for preparing an anti-aging skin repair liquid containing tretinoin according to claim 2, wherein in step S2), the temperature of the deionized water is 45-50 ℃.
5. The method for preparing an anti-aging skin repair liquid containing tretinoin according to claim 2, wherein in step S2), the soaking time of sodium hyaluronate is 2-2.5h.
6. The method for preparing an anti-aging skin repair liquid containing tretinoin according to claim 2, wherein in step S3), the stirring time of the homogenizer is 15-20min, and the homogenizing time is 3-5min.
7. The method for preparing an anti-aging skin repair liquid containing tretinoin according to claim 2, wherein in step S3), the temperature of cooling is 35-40 ℃; in the step S4), the stirring time is 3-5min.
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| US6589514B2 (en) * | 2001-04-17 | 2003-07-08 | Morinda, Inc. | Cosmetic intensive repair serum with morinda citrifolia |
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