CN103202892B - Traditional Chinese medicine composition and skin care essence having acne treatment efficacy and preparation method of essence - Google Patents
Traditional Chinese medicine composition and skin care essence having acne treatment efficacy and preparation method of essence Download PDFInfo
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Abstract
The invention provides acne treatment essence with acne treatment efficacy and a preparation method of the essence. The acne treatment water is prepared by taking traditional Chinese medicine theory of China as a basis, taking skin health as a purpose, taking a composite traditional Chinese medicine extract as a main efficacy additive and taking common substrate components in makeup as assistance. The acne treatment essence provided by the invention has bacteriostasis efficacy, and also has the efficacies of removing pathogenic heat from blood, promoting blood, reducing the stagnation, relieving itching, diminishing inflammation and the like. The composite traditional Chinese medicine extract is naturally green, healthy and safe, and can be widely applied to acne treatment cosmetics.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicinal skin care essence that there is anti-acne and have Chinese medicine composition of bacteriostasis efficacy and preparation method thereof concurrently and prepared by said composition.
Background technology
Comedo is that hair follicle and sebaceous gland are blocked, and a kind of chronic inflammatory disease dermatoses that inflammation causes is common in the youth of both sexes of adolescence, mainly occur in face, cervical region, chest and back, shoulder and upper arm, form pimple, the traditional Chinese medical science claims " acne ", and doctor trained in Western medicine name of disease is " acne ".Adolescence androgen increases, and smegma increases, and makes hair follicle, the different hyperkeratosis of sebaceous gland simultaneously, and the flat dead cell that horny layer comes off falls hair follicle infundibulum, is combined with sebum, produces mixture.If these mixture can not freely be discharged skin surface, in hair follicle, form fat bolt and deposit.When these dyskeratosis cell aggregationes, lower hopper just forms ripe acne while expansion.The bacterial decomposition that sebum is existed in hair follicle, produces fatty acid, and the latter's hair follicle stimulating causes inflammation, and causes follicular wall damage to be broken, and hair follicle content enters corium, thereby, cause the hair follicle inflammatory reaction of varying degree around.The genesis mechanism of comedo, relevant with following three large factors:
(1) the agnogenio property aggravation to androgen steroid (as testosterone, dehydroepiandros-sterone, hydroxyprogesterone) reaction, causes sebum to produce and increases.
(2) propionibacterium acnes hypertrophy.This bacterium is hair follicle normal flora composition, and it acts on machine matter taking sebum for it, and to make it Partial Conversion be free fatty.Propionibacterium acnes also can activating complement path, at least produces two kinds of chemotactic factors, impels inflammation to occur.
(3) capsular epithelium cell quantity increases, and has tackness, forms hair follicle tetention keratosis excessive.The latter's occurrence cause is undistinct yet.Propionibacterium acnes produces free fatty, may be the principal element that comedo forms.
At present there is following problem in popular product for resolving poxes on the market: 1, easily cause skin allergy, and large to skin irritation; 2, add chemical antibacterial to destroy skin normal flora; 3, add some banned substances as hormones such as chloromycetin; 4, add heavy metal substance.
Summary of the invention
The object of the invention is to propose a kind of Chinese medicine composition with acne-removing.
A further object of the present invention is to propose a kind of preparation method of above-mentioned Chinese medicine composition.
The 3rd object of the present invention is to propose to utilize the purposes of the Chinese medicine extract that above-mentioned preparation method prepares.
The 4th object of the present invention is to propose a kind of skin care formulation that includes above-mentioned Chinese medicine extract.
Invention thinking of the present invention is:
The present invention utilizes advanced biotechnology, in conjunction with the traditional theory of Chinese medical science of China, Herba Artemisiae Scopariae, the Fructus Kochiae, Cortex Moutan, Galla Chinensis, Spina Gleditsiae, Spica Prunellae are effectively combined, form compound preparation, and set it as active component, be added in anti-acne elite, make it have antibacterial, short infiltration, the effect of heat-clearing and toxic substances removing, promoting blood circulation and detumescence, thus can effectively prevent and treat dissimilar acne, give life and vigor that skin is new.
For realizing object of the present invention, the present invention adopts following concrete technical scheme:
Have a Chinese medicine composition for acne-removing, the crude drug of described Chinese medicine composition is:
Herba Artemisiae Scopariae 20～30 weight portions, the Fructus Kochiae 20～30 weight portions, Cortex Moutan 10～20 weight portions, Galla Chinensis 10～20 weight portions, Spina Gleditsiae 10～20 weight portions, Spica Prunellae 10～20 weight portions.
A preparation method for above-mentioned Chinese medicine composition, described method step is as follows:
(1) according to above-mentioned weight portion proportioning weighting raw materials;
(2) percent by volume is 75%～80% ethanol extraction twice, extracts for the first time crude drug and ethanol mass volume ratio g/ml is 1:10～1:20, and 50 DEG C～70 DEG C heated and stirred 1～2 hour are filtered to obtain filtrate for the first time; Extract for the second time crude drug and ethanol mass volume ratio g/ml is 1:10～1:20,50 DEG C～70 DEG C of heated and stirred 30min～60min, filter to obtain filtrate for the second time; Filtrate and filtrate mixing for the second time, be concentrated into 0.2g/ml～0.5g/ml for the first time, obtains concentrate;
(3) be to add propylene glycol or butanediol in the concentrate that obtains to step (2) of 1:1～1:2 according to mass ratio, sucking filtration, 3000～5000 revs/min of centrifuging and taking supernatant, to obtain final product.
Have a Chinese medicine extract for acne-removing, described extract is prepared by said method.
Described Chinese medicine extract has the purposes in the skin care formulation of acne-removing in preparation.
Have a skin care formulation for acne-removing, described skin care formulation is prepared from by said extracted thing and the conventional adjuvant of skin care field.
Have a skin care compositions for acne-removing, described compositions is made up of the raw material of following mass percent:
A preparation method for above-mentioned skin protection compositions processed, described method comprises the steps:
(1) water is first heated to water solublity Jojoba oil 80 DEG C～90 DEG C dissolvings completely;
(2) EDETATE SODIUM, hyaluronate sodium, glycerol, allantoin, Aloe powder are added in the solution of step (1), be stirred to after being heated to 80 DEG C～90 DEG C completely and dissolve; Adding AVC to be stirred to completely dissolves again;
(3) cool to below 40 DEG C, add described antiseptic and Chinese medicine extract to stir, to obtain final product.
Have a skin care formulation for acne-removing, described skin care formulation is made up of said method.
Described skin care formulation is essence.
The preparation that above-mentioned raw materials and method prepare is anti-acne essence.According to use approach difference, Chinese medicine composition of the present invention can utilize the simplest method to pulverize and make powder, pats skin, also can realize final technique effect.Or Chinese medicine extract also can be made into other external-use skin care preparations, as external facial cream, cleansing milk, water preparation or spray etc.But be not limited to above-mentioned dosage form, can be according to method preparation known in skin care item industrial circle.
Essence recommendation method of the present invention is: after clean of every day, essence is coated on the skin of pox, massage, treats that essence slowly absorbs gently.
Useful result of the present invention:
Raw material of the present invention is all selected natural plant composition, non-stimulated to skin safe through experiment confirmation, can fundamentally improve skin microenvironment and reach the effect of curing acne, and have clearing away heat and cooling blood concurrently, blood circulation promoting and dispersing pathogen accumulation, antipruritic, press down the effects such as fat antiinflammatory, can also alleviate and eliminate cicatrix pockmark etc.Raw material of the present invention obtains easily, preparation method is easy, green safety, and anti-acne is effective, is easy to be accepted by consumers in general, has good application prospect and market prospect.
Brief description of the drawings
Skin oil and fat changes of contents situation after Fig. 1 anti-acne elite sample uses;
The situation of change of skin oil and fat increment rate after Fig. 2 anti-acne elite sample uses;
The relative increment rate of skin oil and fat after Fig. 3 anti-acne elite sample uses.
Detailed description of the invention
The present embodiment medical material used all can be bought and obtain from China Medicament Group Corp., meets 2005 editions standards of Pharmacopoeia of People's Republic of China.
Preparation raw material of the present invention is originated in table 1:
Table 1
The preparation of embodiment 1 Chinese medicine extract of the present invention
(1) take each raw material of Chinese medicine medicine according to following compositions:
Herba Artemisiae Scopariae 30g, Fructus Kochiae 20g, Cortex Moutan 10g, Galla Chinensis 20g, Spina Gleditsiae 10g, Spica Prunellae 20g.
(2) percent by volume is 75% ethanol extraction twice, extracts for the first time crude drug and ethanol mass volume ratio g/ml is 1:20, and 60 DEG C of heated and stirred 1 hour are filtered to obtain filtrate for the first time; Extract for the second time crude drug and ethanol mass volume ratio g/ml is 1:10,60 DEG C of heated and stirred 30min, filter to obtain filtrate for the second time; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.2g/ml, obtains concentrate;
(3) be in the concentrate that obtains to step (2) of 1:1, to add propylene glycol to redissolve according to mass ratio g/g, sucking filtration, 3000 revs/min of centrifuging and taking supernatant, to obtain final product.
The preparation of embodiment 2 Chinese medicine extract of the present invention
(1) take each raw material of Chinese medicine medicine according to following compositions:
Herba Artemisiae Scopariae 20g, Fructus Kochiae 30g, Cortex Moutan 15g, Galla Chinensis 10g, Spina Gleditsiae 15g, Spica Prunellae 10g.
(2) percent by volume is 80% ethanol extraction twice, extracts for the first time crude drug and ethanol mass volume ratio g/ml is 1:10, and 70 DEG C of heated and stirred 2 hours are filtered to obtain filtrate for the first time; Extract for the second time crude drug and ethanol mass volume ratio g/ml is 1:20,70 DEG C of heated and stirred 60min, filter to obtain filtrate for the second time; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.5g/ml, obtains concentrate;
(3) be in the concentrate that obtains to step (2) of 1:2, to add propylene glycol to redissolve according to mass ratio g/g, sucking filtration, 5000 revs/min of centrifuging and taking supernatant, to obtain final product.
The preparation of embodiment 3 Chinese medicine extract of the present invention
(1) take each raw material of Chinese medicine medicine according to following compositions:
Herba Artemisiae Scopariae 25g, Fructus Kochiae 25g, Cortex Moutan 20g, Galla Chinensis 15g, Spina Gleditsiae 20g, Spica Prunellae 15g.
(2) percent by volume is 80% ethanol extraction twice, extracts for the first time crude drug and ethanol mass volume ratio g/ml is 1:15, and 50 DEG C of heated and stirred 1.5 hours are filtered to obtain filtrate for the first time; Extract for the second time crude drug and ethanol mass volume ratio g/ml is 1:15,50 DEG C of heated and stirred 40min, filter to obtain filtrate for the second time; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.3g/ml, obtains concentrate;
(3) be in the concentrate that obtains to step (2) of 1:1.5, to add propylene glycol to redissolve according to mass ratio g/g, sucking filtration, 4000 revs/min of centrifuging and taking supernatant, to obtain final product.
The preparation of embodiment 4 essences of the present invention
Raw material and proportioning (mass percent), in table 2:
Table 2
Preparation method:
(1) with deionized water first by water solublity Jojoba oil heating for dissolving, 80 DEG C of heating-up temperatures;
(2) EDETATE SODIUM, hyaluronate sodium, glycerol, allantoin, Aloe powder are joined in the solution of step (1), be heated to 80 DEG C after stirring and dissolving; Add AVC, stir, it is dissolved completely.
(3) be cooled to below 40 DEG C, add antiseptic and Chinese medicine extract, stir, obtain anti-acne elite finished product.
The preparation of embodiment 5 essences of the present invention
Raw material and proportioning (mass percent), in table 3
Table 3
Preparation method:
(1) with deionized water first by water solublity Jojoba oil heating for dissolving, 90 DEG C of heating-up temperatures;
(2) EDETATE SODIUM, hyaluronate sodium, glycerol, allantoin, Aloe powder are joined in deionized water, be heated to 90 DEG C after stirring and dissolving; Add AVC, stir, it is dissolved completely.
(3) be cooled to below 40 DEG C, add antiseptic and Chinese medicine extract, stir, obtain anti-acne elite finished product.
The preparation of embodiment 4 essences of the present invention
Raw material and proportioning (mass percent), in table 4
Table 4
Preparation method:
(1) with deionized water first by water solublity Jojoba oil heating for dissolving, 85 DEG C of heating-up temperatures
(2) EDETATE SODIUM, hyaluronate sodium, glycerol, allantoin, Aloe powder are joined in deionized water, be heated to 85 DEG C after stirring and dissolving, add AVC, stir, it is dissolved completely;
(3) be cooled to below 40 DEG C, add antiseptic and Chinese medicine extraction liquid, stir, obtain anti-acne elite finished product.
Effect experiment of the present invention
One, anti-acne elite anti-acne effect
1, inhibition zone
1) experimental principle:
In the culture medium of inoculating for examination strain, impose quantitative sample, utilize the scattering and permeating effect of sample in agar culture medium, after certain hour, sample diffusion reaches certain limit.The scope reaching at Mlc, the growth of indicator bacteria is just suppressed, produces an aseptic transparent region, is called inhibition zone.Under certain condition with certain limit in, the diameter of inhibition zone and linearly functional relationship of the logarithm of sample concentration.Utilize this principle, can compare the size of antibacterial virulence, or the content of working sample effective ingredient.
2) inhibition zone of In Vitro Bacteriostasis experiment the results are shown in Table 5:
Table 5 Chinese medicine extraction liquid and erythromycin benzoyl peroxide MIC measurement result (mg/ml)
| Group | Propionibacterium acnes | Staphylococcus aureus | Staphylococcus epidermidis | Fructus Citri Limoniae staphylococcus |
| Embodiment 1 extract | 27.96 | 30.25 | 16.42 | 66.35 |
| Erythromycin | 12.71 | 30.25 | 30.42 | 66.35 |
3) result
Can find out from this experiment, embodiment 1 extract and erythromycin benzoyl peroxide all have bacteriostasis in various degree, but the bacteriostasis of the two there were significant differences.Embodiment 1 extract is 7.96mg/ml to the MIC of propionibacterium acnes, and fungistatic effect is the strongest, and the MIC of staphylococcus epidermidis and staphylococcus aureus is respectively to 16.42,30.25, is 66.35 to the staphylococcic MIC of Fructus Citri Limoniae, and its bacteriostasis is the most weak; Erythromycin benzoyl peroxide is best to the fungistatic effect of staphylococcus epidermidis, staphylococcus aureus, MIC measurement result is 30.42,30.25mg/ml, all low compared with treatment group to Fructus Citri Limoniae staphylococcus bacteriostasis, MIC value 66.35mg/ml, bacteriostasis to propionibacterium acnes is the poorest, MIC value is 12.71mg/ml, and curative effect is starkly lower than treatment group.The Chinese medicine extract that as can be seen from the results prepared by the embodiment of the present invention 1 has good bacteriostasis efficacy, and it is identical that inventor repeats above-mentioned experimental result with other embodiment preparing products.
2, product control oil effect
1) experimental principle
Human experimentation, by particular experiment, crowd forms test population, the test subject variation of skin oil and fat content before and after (and cosmetic industry composition) that makes to apply some make up, thus determine cosmetics (or functional component) press down fat effect.
2) experimental apparatus and sample
Experimental apparatus: skin oil and fat tester
Sample: embodiment 4 anti-acne essences.
Blank: tested position is not used any cosmetics.
3) experiment crowd
Experimenter amounts to 30 people.Concrete sex composition and age structure are determined at random.If there are during this time 2 people to occur untoward reaction, stop test; Result is not found untoward reaction.
4) experimental technique
1. select experimenter's forehead (point left and right two parts) cycle labeling successively: tested region samples group and blank region;
2. technical staff uses skin oil and fat tester
3-5 time, test test position, averages, and is designated as initial value.
3. test position experimenter and smear sample, use anti-acne elite.
4. experimenter, making continuously to apply some make up after one hour, two hours, four hours, uses skin oil and fat tester by technical staff
measure 3-5 time, average.
5. the numerical value that statistics records, analyzes its skin oil and fat changes of contents rule.
5) interpretation of result
Fat content changes
Fat content variation was reflected in test period, Experimental Area fat content change with time.Its value is larger, and fat content is larger, otherwise fat content is less.
As shown in Figure 1, sample sets is compared with blank group after using 1 hour, and diversity is obvious; In sample uses 4 hours, the fat content of sample sets is starkly lower than blank group.
Oils and fats increment rate changes
Oils and fats increment rate=(sample sets fat content-initial fat content)/initial fat content
As shown in Figure 2, within test period,, after sample uses 1 hour, compare with initial value in tested position, and skin oil and fat secretion increment rate is starkly lower than blank group, and always lower than blank group.
Press down fat rate
The relative increment rate of oils and fats, presses down fat rate=(sample sets fat content-blank group fat content)/blank group fat content; This value is less, illustrates that the relative blank sample of test specimen presses down fat effect more obvious.
As shown in Figure 3, within test period, tested position is used after sample, and it presses down fat rate is negative value always.
6) conclusion
Using after sample, the fat secretion amount at tested position is starkly lower than the tested region of not smearing sample, illustrates that product has the ability that suppresses skin oil and fat secretion.It is identical that inventor repeats above-mentioned experimental result with other embodiment preparing products.
3, prevent that pockmark from telling on
1) experimental principle
The pockmark one reparation reaction that to be body produce tissue injury, when the damage of skin is dark and corium or large-area skin blemish, the epidermis at this position can not be regenerated, will be by corium fabric cell, the blood vessel of collagen and hypertrophy replaces, and has so just occurred pockmark.Pox scar is because infection inflammation or external force extruding institute forms, and the inflammatory response of Skin Cell has caused the destruction to skin histology and injured the collagen protein of corium too many, has caused the generation of cicatrix.Therefore improve skin environment, keep skin elasticity, ensure that collagen protein is not excessively degraded, can reduce the generation of cicatrix.
Matrix metallopeptidase 1 (Matrix Metalloproteinases 1, MMP-1) is the key enzyme of degrade collagen albumen, and the activity that suppresses MMP-1 can effectively reduce the collagen protein amount being degraded, thereby reduces the generation of cicatrix.Therefore the effect by the active reaction plant functional component of vitro inhibition Fibroblast collagenase (MMP-1), cicatrix being produced.
Set up MMP-1 enzyme reaction experiment porch, taking this platform as basis, under the prerequisite of destructive enzyme reaction system not, add plant extract functional component, detect the variation of product fluorescence intensity by enzyme reaction system, the variation of reflection enzyme activity indirectly, thus the influence of this plant extraction liquid functional component to MMP-1 activity reflected.
2) experimental procedure
1. solvent preparation:
(1) preparation buffer (50mmol/L HEPES, 0.12mol/L NaCl, 10mmol/L CaCl2,20 μ mol/L ZnSO4,0.05%Brij-35, pH=7.5),
(2) MMP-1 proenzyme is for subsequent use with buffer gradient dilution to 0.22 μ g/100 μ L;
(3) fluorogenic substrate DQ-gelatin is for subsequent use with buffer gradient dilution to 0.20 μ g/100 μ L;
(4) in the 0.1mol/L of 1L NaOH solution, add the zymoexcitator APMA of 30mmol, form APMA storing solution (30mmol/L) for subsequent use;
(5) sample (prepared by embodiment 1) is mixed with to certain density solution for standby;
The activation of 2.MMP-1 proenzyme: the volume ratio (MMP:APMA) of MMP-1 proenzyme solution (0.22 μ g/100 μ L) and APMA solution (30mmol/L) being pressed to 10:1 is mixed, hatches 45min activation at 37 ° of C;
3. application of sample: MMP-1 solution (concentration has been reduced to 0.20 μ g/100 μ L) the 40 μ L that get after activation add in 96 hole ELISA Plate, add again sample (prepared by embodiment 1) solution 8 μ L, fluorogenic substrate DQ-gelatin solution (0.20 μ g/100 μ L) 52 μ L, making end reaction system is 100 μ L;
Table 6 vitro inhibition MMP-1 experiment application of sample table
4. constant-temperature incubation: the 96 hole ELISA Plate that complete application of sample are put into 37 DEG C of incubator constant-temperature incubation 600s;
5. experimental result detects
(1). before reaction, be 460nm in excitation wavelength, under the testing conditions that emission wavelength is 520nm, detect the fluorescence intensity for the treatment of measuring plants functional component;
(2). after reaction system stops hatching, detect immediately with Bio-Red FLx-800 fluorescence microplate reader the fluorescence intensity of whole reaction system, excitation wavelength is 460nm, and emission wavelength is 520nm.
6. Data Processing in Experiment
MMP-1 suppresses percent (%)=[1-(A
1-A
2)/Ao] * 100%
A
1the fluorescence intensity of sample (prepared by embodiment 1) inhibition group is added in-representative
A
2the fluorescence intensity of-representative sample (prepared by embodiment 1) self
Ao-the represent fluorescence intensity of blank group
Suppress this kind of plant functional component of the larger expression of percent more remarkable to the active inhibition of MMP-1.
3) experimental result
Chinese medicine extraction liquid is 97.62% to the maximum inhibition of MMP-1 after tested.It is identical that inventor repeats above-mentioned experimental result with other embodiment preparing products.
Conclusion: this product prevents that pockmark from producing and desalination pockmark has positive effect.
4, anti-acne effect clinical data and method
4.1 data and method
4.1.1 case selection
200 routine patients are divided into treatment group, matched group at random.Treatment group 100 examples, 13 years old～33 years old age, average 20.5 years old; Man's 40 examples, female's 60 examples; The course of disease 2 months～10 years, average 3.1 years; Wherein acne, papular type 58 examples, pustule type 30 examples, pockmark type 12 examples.Matched group 100 examples, 14 years old～35 years old age, average 21.5 years old; Man's 37 examples, female's 63 examples; The course of disease 2 months～12 years, average 3.6 years; Wherein acne, papular type 60 examples, pustule type 27 examples, pockmark type 12 examples.2 groups of Genders, age, courses of disease are learned processing by statistics, and difference not statistically significant (P > 0.05), has comparability.
4.1.2 Therapeutic Method: treatment group external embodiment 4 prepares anti-acne elite, 4 weeks is 1 course for the treatment of at every day 2 times.Matched group is with erythromycin benza gel every day 2 times, 4 weeks courses for the treatment of.Observing skin lesion improves degree and adds up clinical efficacy.
4.1.3 clinical efficacy
Skin lesion counting × 100% before curative effect=(the rear skin lesion counting of skin lesion counting-treatment before treatment)/treatment
Recovery from illness: skin lesion disappears more than 90%, only has a little pigmentation;
Effective: skin lesion disappears 60%～90%, and symptom alleviates;
Effective: skin lesion disappears 20%～60%, symptom is improved;
Invalid: the skin lesion < 20% that disappears, clinical symptoms is not improved;
Total effective rate=cure rate+obvious effective rate
Onset time is judged: the natural law that after medication, symptom alleviates, deflorescence reaches more than 20% is onset time.
Treatment group 55 examples of fully recovering, effective 42 examples, total effective rate is 97.0%, matched group 31 examples of fully recovering, effective 42 examples, total effective rate is 73.0%, treatment group is apparently higher than matched group.It is identical that inventor repeats above-mentioned experimental result with other embodiment preparing products.
Table 7 treatment group and matched group curative effect comparison (%)
| Group | Number of cases | Recovery from illness | Effective | Invalid | Cure rate | Effective percentage |
| Treatment group | 100 | 55 | 42 | 3 | 55.0% | 97.0% |
| Matched group | 100 | 31 | 42 | 27 | 31.0% | 73.0% |
4.1.4 onset time comparison: treatment group: 1d～3d onset patient 42 examples, 3d～7d onset 30 examples, > 7d onset 28 examples; Matched group: 1d～3d onset patient 29 examples, 3d～7d onset 27 examples, > 7d onset 46 examples.Treatment group and matched group comparison, onset time obviously shifts to an earlier date.It is identical that inventor repeats above-mentioned experimental result with other embodiment preparing products.
Table 8 matched group and treatment group onset time comparison
| Group | Number of cases | 1～3d | 3～7d | ﹥7d |
| Treatment group | 100 | 42 | 30 | 28 |
| Matched group | 100 | 29 | 27 | 46 |
Claims (9)
1. an external medicine composition with acne-removing, is characterized in that, the crude drug of described external medicine composition is:
Herba Artemisiae Scopariae 20～30 weight portions, the Fructus Kochiae 20～30 weight portions, Cortex Moutan 10～20 weight portions, Galla Chinensis 10～20 weight portions, Spina Gleditsiae 10～20 weight portions, Spica Prunellae 10～20 weight portions.
2. a preparation method for external medicine composition described in claim 1, is characterized in that, described method step is as follows:
(1) according to weight portion proportioning weighting raw materials described in claim 1;
(2) percent by volume is 75%～80% ethanol extraction twice, extracts for the first time crude drug and ethanol mass volume ratio g/ml is 1:10～1:20, and 50 DEG C～70 DEG C heated and stirred 1～2 hour are filtered to obtain filtrate for the first time; Extract for the second time crude drug and ethanol mass volume ratio g/ml is 1:10～1:20,50 DEG C～70 DEG C of heated and stirred 30min～60min, filter to obtain filtrate for the second time; Filtrate and filtrate mixing for the second time, be concentrated into 0.2g/ml～0.5g/ml for the first time, obtains concentrate;
(3) be to add propylene glycol or butanediol in the concentrate that obtains to step (2) of 1:1～1:2 according to mass ratio, sucking filtration, 3000～5000 revs/min of centrifuging and taking supernatant, to obtain final product.
3. an external medicine composition with acne-removing, is characterized in that, described external medicine composition is prepared by method described in claim 2.
4. described in claim 3, external medicine composition has the purposes in the skin care formulation of acne-removing in preparation.
5. a skin care formulation with acne-removing, is characterized in that, described skin care formulation is prepared from by external medicine composition described in claim 3 and the conventional adjuvant of skin care field.
6. a skin care compositions with acne-removing, is characterized in that, described skin care compositions is made up of the raw material of following mass percent:
7. a preparation method for skin care compositions described in claim 6, is characterized in that comprising the steps:
(1) water is first heated to water solublity Jojoba oil 80 DEG C～90 DEG C dissolvings completely;
(2) EDETATE SODIUM, hyaluronate sodium, glycerol, allantoin, Aloe powder are added in the solution of step (1), be stirred to after being heated to 80 DEG C～90 DEG C completely and dissolve; Adding AVC to be stirred to completely dissolves again;
(3) cool to below 40 DEG C, add antiseptic and external medicine composition to stir, to obtain final product.
8. a skin care compositions with acne-removing, is characterized in that, described skin care compositions is made up of method described in claim 7.
9. the skin care compositions with acne-removing as claimed in claim 8, is characterized in that, described skin care compositions is essence.
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| CN103989602A (en) * | 2014-05-31 | 2014-08-20 | 广州丹奇日用化工厂有限公司 | Calanthe discolor lindl extract, as well as preparation method and application thereof |
| CN105194286B (en) * | 2015-05-28 | 2019-03-01 | 孟宏 | Have effects that radiation protection and repair the external skin-care composition of skin barrier, essence and preparation method thereof |
| CN105106350B (en) * | 2015-09-08 | 2018-09-11 | 北京工商大学 | Have effects that press down external medicine composition, phosphatide complexes of acne and its preparation method and application |
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| CN105919876A (en) * | 2016-06-12 | 2016-09-07 | 马殿伟 | Traditional Chinese medicine composition containing cerasusssp and applied to acne removing cosmetics |
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