CN103202797B - Skin care composition and water aqua having acne treatment efficacy and preparation method of water aqua - Google Patents
Skin care composition and water aqua having acne treatment efficacy and preparation method of water aqua Download PDFInfo
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Abstract
The invention provides acne treatment water with acne treatment efficacy and a preparation method of the water. The acne treatment water is prepared by taking traditional Chinese medicine theory of China as a basis, taking skin health as a purpose, taking a composite traditional Chinese medicine extract as a main efficacy additive and taking common substrate components in makeup as assistance. The acne treatment water provided by the invention has bacteriostasis efficacy, and also has the efficacies of removing pathogenic heat from blood, promoting blood, reducing the stagnation, relieving itching, diminishing inflammation and the like. The composite traditional Chinese medicine extract is naturally green, healthy and safe, and can be widely applied to acne treatment cosmetics.
Description
Technical field
The present invention relates to a kind of skin care compositions, specifically a kind of have anti-acne and the skin care compositions having bacteriostasis efficacy concurrently and the water preparation that prepared by this skin care compositions and preparation method thereof.
Background technology
Comedo is that hair follicle and sebaceous gland are blocked, a kind of chronic inflammatory skin that inflammation causes is sick, be common in the youth of both sexes of adolescence, mainly occur in and be usually apt to occur in face, cervical region, chest and back, shoulder and upper arm, form pimple, the traditional Chinese medical science claims " acne ", and doctor trained in Western medicine name of disease is " acne ".Adolescence androgen increases, and smegma increases, and makes the different hyperkeratosis of hair follicle, sebaceous gland simultaneously, and the flat dead cell that horny layer comes off falls hair follicle infundibulum, is combined with sebum, produces mixture.If these mixture freely can not discharge skin surface, and deposit form fat bolt in hair follicle.When these dyskeratosis cell aggregationes, when lower hopper expands, just form ripe acne.Sebum is by the bacterial decomposition existed in hair follicle, and produce fatty acid, the latter's hair follicle stimulating causes inflammation, and causes follicular wall lesion ruptures, and hair follicle content enters corium, thus, cause the inflammatory reaction of perifollicolar varying degree.The genesis mechanism of comedo, relevant with following three large factors:
(1) to the agnogenio property aggravation that androgenic steroids (as testosterone, dehydroepiandros-sterone, hydroxyprogesterone) reacts, cause sebum to produce and increase.
(2) propionibacterium acnes hypertrophy.This bacterium is hair follicle normal flora composition, and it, and makes it to be partially converted into free fatty for it acts on machine matter with sebum.Propionibacterium acnes also can activating complement path, at least produces two kinds of chemotactic factors, impels inflammation to occur.
(3) capsular epithelium cell quantity increases, and has tackness, forms hair follicle tetention keratosis excessive.The latter's occurrence cause is undistinct yet.Propionibacterium acnes produces free fatty, may be the principal element that comedo is formed.
The problem of the product for resolving poxes on market: 1, easily cause skin allergy is large to skin irritation; 2, add chemical antibacterial and destroy skin normal flora; 3, some banned substances are added as hormones such as chloromycetin; 4, heavy metal substance is added.
To sum up, this area is badly in need of a kind ofly can making up prior art defect and the good skin care formulation of technique effect.
Summary of the invention
The object of the invention is to propose a kind of skin care compositions with acne-removing.
Another object of the present invention is to propose a kind of method above-mentioned skincare composition room being prepared into water preparation.
Invention thinking of the present invention is:
The present invention utilizes advanced biotechnology, in conjunction with the theory of Chinese medical science of Chinese tradition, Herba Artemisiae Scopariae, the Fructus Kochiae, Cortex Moutan, Galla Chinensis, Spina Gleditsiae, Spica Prunellae are effectively combined, form compound preparation, and it can be used as active component, be added in anti-acne water preparation, make it have antibacterial, short infiltration, the effect of heat-clearing and toxic substances removing, promoting blood circulation and detumescence, thus effectively can prevent and treat dissimilar acne, give the new life of skin and vigor.
For realizing object of the present invention, the present invention adopts following concrete technical scheme:
Have a skin care compositions for acne-removing, described skin care compositions comprises the raw material of following mass percent:
Described Chinese medicine extract is obtained through the extraction of field of Chinese medicines general extraction methods by the crude drug of following weight:
Herba Artemisiae Scopariae 20 ~ 30, the Fructus Kochiae 10 ~ 30, Cortex Moutan 10 ~ 20, Galla Chinensis 10 ~ 20, Spina Gleditsiae 10 ~ 20, Spica Prunellae 10 ~ 20.
Preferably, described Chinese medicine extract is obtained through following method extraction by the crude drug of following weight:
(1) according to following weight parts proportioning weighting raw materials:
Herba Artemisiae Scopariae 20 ~ 30, the Fructus Kochiae 20 ~ 30, Cortex Moutan 10 ~ 20, Galla Chinensis 10 ~ 20, Spina Gleditsiae 10 ~ 20, Spica Prunellae 10 ~ 20;
(2) percent by volume is 75% ~ 80% ethanol extraction twice, and it is 1:10 ~ 1:20 that first time extracts crude drug and ethanol mass volume ratio g/ml, 60 DEG C ~ 70 DEG C heated and stirred 1 ~ 2 hour, filters to obtain filtrate for the first time; Second time extracts crude drug and ethanol mass volume ratio g/ml is 1:10 ~ 1:20,60 DEG C ~ 70 DEG C heated and stirred 30min ~ 60min, filters to obtain second time filtrate; First time, filtrate mixed with second time filtrate, and rotary evaporation is concentrated into 0.2g/ml ~ 0.5g/ml, obtains concentrate;
(3) add propylene glycol or butanediol, sucking filtration, 3000 ~ 5000 revs/min of centrifuging and taking supernatant according in the mass ratio concentrate that to be 1:1 ~ 1:2 obtain to step (2), collect filtrate, to obtain final product.
Above-mentioned skin care compositions also comprises C phase, and described C phase and consumption are: antiseptic 0.01 ~ 0.5wt%.
A preparation method for above-mentioned skin protection compositions, described method comprises the steps:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added to the water be heated to 80 DEG C ~ 90 DEG C after stirring and evenly mixing cooling;
(2) cool to less than 40 DEG C, add Chinese medicine extract and stir, to obtain final product.
A preparation method for above-mentioned skin protection compositions, described method step is as follows:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added to the water be heated to 80 DEG C ~ 90 DEG C after stir cooling;
(2) cool to less than 40 DEG C, add antiseptic and Chinese medicine extract stirs, to obtain final product.
Have a skin care formulation for acne-removing, described skin care formulation is made up of said method.
The above-mentioned skin care formulation with acne-removing, described skin care formulation is water preparation, the cosmetic water that water preparation and skin care field are commonly used.
Different according to use approach, Chinese medicine composition of the present invention can be pulverized and mixed makes powder flush coat, also can be made into other external-use skin care preparations, as cleansing milk, spray or essence etc. after extracting.Be not limited to above-mentioned dosage form, according to method known in skin care industry field, aforementioned pharmaceutical compositions can be made various different external preparation by known method.
The cosmetic water of water preparation of the present invention namely on ordinary days in skin care formulation, recommendation method is: after clean of every day, anti-acne water preparation is coated on the skin of pox, massages gently, treat that water slowly absorbs.
Beneficial outcomes of the present invention:
Raw material of the present invention all selects natural plant composition, non-stimulated to skin safe, Chinese medicine extract itself not only has bacteriostasis efficacy, also has clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, antipruritic, the effects such as antiinflammatory, can improve skin microenvironment, fundamentally the skin problem such as Acne treatment, meanwhile, the present invention has pockmark or cicatrix and well prevents and dispel effect.Raw material of the present invention obtains easily, preparation method is easy, and green safety, anti-acne effect is good, is easy to be accepted by consumers in general, has good application prospect and market prospect.
Accompanying drawing explanation
Skin oil and fat changes of contents situation after Fig. 1 acne removing water sample uses
The situation of change of skin oil and fat increment rate after Fig. 2 acne removing water sample uses
The relative increment rate of skin oil and fat after Fig. 3 acne removing water sample uses
Fig. 4 is the inhibition of acne removing water to pimple;
Fig. 5 is the inhibition of acne removing water to pustule;
First week volunteer's in-service evaluation effect after Fig. 6 acne removing water uses;
Second week volunteer in-service evaluation effect after Fig. 7 acne removing water uses;
3rd week volunteer's in-service evaluation effect after Fig. 8 acne removing water uses;
4th week volunteer in-service evaluation effect after Fig. 9 acne removing water uses;
After Figure 10 acne removing water uses surrounding, volunteer produces evaluation of effect to preventing pockmark.
Detailed description of the invention
Acne removing water provided by the invention is main additive with composite traditional Chinese medicine extract, is aided with conventional matrix components in cosmetics formulated.Medical material used all can be bought from China Medicament Group Corp. and obtain, and meets Pharmacopoeia of People's Republic of China 2005 editions standards.Invention formulation raw material sources are in table 1.
Table 1
The preparation of embodiment 1 anti-acne water preparation of the present invention
Raw material and proportioning (mass percent)
The preparation of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 30g, Fructus Kochiae 20g, Cortex Moutan 10g, Galla Chinensis 20g, Spina Gleditsiae 10g, Spica Prunellae 20g.
(2) percent by volume is 75% ethanol extraction twice, and it is 1:10 that first time extracts crude drug and ethanol mass volume ratio g/ml, 60 DEG C of heated and stirred 1 hour, filters to obtain filtrate for the first time; Second time extracts crude drug and ethanol mass volume ratio g/ml is 1:10,60 DEG C of heated and stirred 30min, filters to obtain second time filtrate; First time, filtrate mixed with second time filtrate, and rotary evaporation is concentrated into 0.2g/ml, obtains concentrate;
(3) add propylene glycol, sucking filtration, 3000 revs/min of centrifuging and taking supernatant according in the mass volume ratio g/ml concentrate that to be 1:2 obtain to step (2), collect filtrate, to obtain final product.
The preparation of anti-acne water preparation
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added in deionized water be heated to 80 DEG C after stirring and evenly mixing cooling;
(2) cool to less than 40 DEG C, add described Chinese medicine extract and stir, to obtain final product.
The preparation of embodiment 2 anti-acne water preparation of the present invention
Raw material and proportioning (mass percent)
The preparation of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 20g, Fructus Kochiae 20g, Cortex Moutan 10g, Galla Chinensis 10g, Spina Gleditsiae 20g, Spica Prunellae 10g.
(2) percent by volume is 80% ethanol extraction twice, and it is 1:20 that first time extracts crude drug and ethanol mass volume ratio g/ml, 70 DEG C of heated and stirred 2 hours, filters to obtain filtrate for the first time; Second time extracts crude drug and ethanol mass volume ratio g/ml is 1:20,70 DEG C of heated and stirred 60min, filters to obtain second time filtrate; First time, filtrate mixed with second time filtrate, and rotary evaporation is concentrated into 0.3g/ml, obtains concentrate;
(3) add butanediol, sucking filtration, 5000 revs/min of centrifuging and taking supernatant according in the mass volume ratio g/ml concentrate that to be 1:1 obtain to step (2), collect filtrate, to obtain final product.
The preparation of anti-acne water preparation:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added in deionized water be heated to 90 DEG C after stirring and evenly mixing cooling;
(2) cool to less than 40 DEG C, add described antiseptic and Chinese medicine extract stirs, to obtain final product.
The preparation of embodiment 3 acne removing water of the present invention
Raw material and proportioning (mass percent)
The preparation of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 25g, Fructus Kochiae 30g, Cortex Moutan 20g, Galla Chinensis 15g, Spina Gleditsiae 15g, Spica Prunellae 15g.
(2) percent by volume is 75% ethanol extraction twice, and it is 1:15 that first time extracts crude drug and ethanol mass volume ratio g/ml, 65 DEG C of heated and stirred 1.5 hours, filters to obtain filtrate for the first time; Second time extracts crude drug and ethanol mass volume ratio g/ml is 1:15,65 DEG C of heated and stirred 40min, filters to obtain second time filtrate; First time, filtrate mixed with second time filtrate, and rotary evaporation is concentrated into 0.5g/ml, obtains concentrate;
(3) add propylene glycol or butanediol, sucking filtration, 4000 revs/min of centrifuging and taking supernatant according in the mass volume ratio g/ml concentrate that to be 1:1 obtain to step (2), collect filtrate, to obtain final product.
The preparation of anti-acne water preparation:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added in deionized water be heated to 85 DEG C after stirring and evenly mixing cooling;
(2) cool to less than 40 DEG C, add described antiseptic and Chinese medicine extract stirs, namely prepare described skin care formulation.
Efficacy experiments of the present invention
One. anti-acne water preparation anti-acne effect
The mensuration of antibacterial circle diameter size---filter paper enzyme
1) experimental principle:
Inoculating in the culture medium for examination strain, imposing quantitative sample (prepared by embodiment 1), utilizing the scattering and permeating effect of sample in agar culture medium, after certain hour, sample permeates diffusion reaches certain limit.In the scope that Mlc reaches, the growth of indicator bacteria is just suppressed, produces an aseptic transparent region, is called inhibition zone.Parallel 1,2,3 is inhibition zone sizes of sample, and when general experiment, one group of experimental data will do three parallel laboratory tests, last experimental result be get three parallel numerical value meansigma methods as last result.Under certain condition with in certain limit, the diameter of inhibition zone and the logarithm of sample concentration linearly functional relationship.Utilize this principle, the size of antibacterial virulence can be compared, or the content of working sample effective ingredient.
2) inhibition zone of antibacterial experiment in vitro the results are shown in Table 2
Table 2
| Group | Parallel 1 | Parallel 2 | Parallel 3 | Average diameter (mm) |
| Staphylococcus aureus | 18.42 | 18.62 | 18.88 | 18.64 |
| Staphylococcus epidermidis | 40.42 | 40.92 | 40.22 | 40.52 |
The criterion of In Vitro Bacteriostasis qualitative results: it is insensitive (-) that antibacterial circle diameter is less than 8mm, 8 ~ 13mm is less sensitive (+), and 13 ~ 19mm is medium sensitivity (++), and more than 19mm is extremely sensitive (+++).It is identical with above-mentioned experimental result that inventor repeats above-mentioned experimental result with other embodiment products.
2, product control oil effect
1) experimental principle
Human experimentation, by particular experiment, crowd forms test population, and test subject makes to apply some make up the change of skin oil and fat content before and after (and cosmetic industry composition), thus deterministic cosmetic (or functional component) press down fat effect.
2) experimental apparatus and sample
Experimental apparatus: skin oil and fat tester
Sample: embodiment 1 prepares anti-acne water preparation.
Blank: recipient site does not use any cosmetics.
3) Subject Population
Experimenter amounts to 30 people.Concrete sex composition and age structure are determined at random.If period has 2 people to occur untoward reaction, then stop test; Result does not find untoward reaction.
4) experimental technique
1. experimenter's forehead (point left and right two parts) cycle labeling is successively selected: tested region samples group and blank region;
2. technical staff uses skin oil and fat tester
3-5 time, test test position, averages, is designated as initial value.
3. smear sample at subject position, use acne removing water.
4. experimenter is after making continuously to apply some make up one hour, two hours, four hours, uses skin oil and fat tester by technical staff
measure 3-5 time, average.
5. add up the numerical value recorded, analyze its skin oil and fat changes of contents rule.
5) interpretation of result
Fat content changes
Fat content change is reflected in test period, Experimental Area fat content Changing Pattern in time.Its value is larger, and fat content is larger, otherwise fat content is less.
As Fig. 1, sample sets use after 1 hour compared with blank group, diversity is obvious; Sample uses in 4 hours, and the fat content of sample sets is starkly lower than blank group.
Oils and fats increment rate changes
Oils and fats increment rate=(sample sets fat content-initial fat content)/initial fat content
As Fig. 2, within test period, recipient site is after sample uses 1 hour, and compared with initial value, skin oil and fat secretion increment rate is starkly lower than blank group, and always lower than blank group.
Press down fat rate
The relative increment rate of oils and fats, namely presses down fat rate=(sample sets fat content-blank group fat content)/blank group fat content; This value is less, illustrates that test specimen presses down fat effect relative to blank sample more obvious.
As Fig. 3, within test period, after recipient site uses sample, it presses down fat rate is negative value always.
6) conclusion
After use sample, the fat secretion amount of recipient site is starkly lower than the tested region of not smearing sample, illustrates that product has the ability suppressing skin oil and fat secretion.It is identical with above-mentioned experimental result that inventor repeats above-mentioned experimental result with other embodiment products.
3, prevent pockmark from telling on
1) experimental principle
The pockmark one reparation reaction that to be body produce tissue injury, when the damage of skin is dark and corium or large-area skin blemish, the epidermis at this position can not regenerate, will by corium fabric cell, and the blood vessel of collagen and hypertrophy replaced, and has so just occurred pockmark.Pox scar is because infection inflammation or external force extruding formed, the inflammatory response of Skin Cell cause to the destruction of skin histology and injure corium collagen protein too much, cause the generation of cicatrix.Therefore improve skin environment, keep skin elasticity, ensure that collagen protein is not excessively degraded, the generation of cicatrix can be reduced.
Matrix metallopeptidase 1 (Matrix Metalloproteinases1, MMP-1) is the key enzyme of degrade collagen albumen, suppresses the activity of MMP-1 effectively can reduce the collagen protein amount be degraded, thus reduces the generation of cicatrix.Therefore the effect that the active reaction plant functional component passing through vitro inhibition Fibroblast collagenase (MMP-1) produces cicatrix.
Set up MMP-1 enzyme reaction experiment porch, based on this platform, under the prerequisite of not destructive enzyme reaction system, add plant extract functional component, the change of product fluorescence intensity is detected by enzyme reaction system, the change of indirect reflection enzyme activity, thus reflect that this plant extraction liquid functional component is to the influence of MMP-1 activity.
2) experimental procedure
1. solvent preparation:
(1) buffer (50mmol/L HEPES, 0.12mol/L NaCl, 10mmol/L CaCl2,20 μm of ol/L ZnSO4,0.05%Brij-35, pH=7.5) is prepared,
(2) MMP-1 proenzyme buffer gradient is diluted to 0.22 μ g/100 μ L for subsequent use;
(3) fluorogenic substrate DQ-gelatin buffer gradient is diluted to 0.20 μ g/100 μ L for subsequent use;
(4) in the 0.1mol/L NaOH solution of 1L, add the zymoexcitator APMA of 30mmol, form APMA storing solution (30mmol/L) for subsequent use;
(5) embodiment 1 is prepared water preparation and be mixed with certain density solution for standby;
The activation of 2.MMP-1 proenzyme: MMP-1 proenzyme solution (0.22 μ g/100 μ L) and APMA solution (30mmol/L) are mixed by the volume ratio (MMP:APMA) of 10:1, hatches 45min activation at 37 ° of C;
3. application of sample: get the MMP-1 solution after activation (concentration has reduced to 0.20 μ g/100 μ L) 40 μ L and add in 96 hole ELISA Plate, add certain again and treat measuring plants functional component solution 8 μ L, fluorogenic substrate DQ-gelatin solution (0.20 μ g/100 μ L) 52 μ L, make end reaction system be 100 μ L;
Table 3 vitro inhibition MMP-1 tests application of sample table
4. constant-temperature incubation: the 96 hole ELISA Plate completing application of sample are put into 37 DEG C of incubator constant-temperature incubation 600s;
5. experimental result detects
(1) reaction is front is 460nm in excitation wavelength, and emission wavelength is detect the fluorescence intensity of testing sample (prepared by embodiment 1) under the testing conditions of 520nm;
(2) reaction system stopping detects the fluorescence intensity of whole reaction system immediately with Bio-Red FLx-800 fluorescence microplate reader after hatching, and excitation wavelength is 460nm, and emission wavelength is 520nm.
6. Data Processing in Experiment
MMP-1 suppresses percent (%)=[1-(A
1-A
2)/Ao] * 100%
A
1the fluorescence intensity of sample (prepared by embodiment 1) suppression group is added in-representative
A
2-represent the fluorescence intensity of testing sample self
The fluorescence intensity of Ao-represent blank group
Suppress the active inhibition of percent this kind of plant functional component of larger expression to MMP-1 more remarkable.
3) experimental result
Chinese medicine extraction liquid is 98.41% to the maximum inhibition of MMP-1 after tested.
Conclusion: this product prevents pockmark from producing and desalination pockmark has positive effect.It is identical with above-mentioned experimental result that inventor repeats above-mentioned experimental result with other embodiment products.
4, the organoleptic indicator of anti-acne effect
Choose 100 volunteers, 13 years old ~ 35 years old age, average 21.5 years old, each 50 of men and women.All there are pimple, pustule, pockmark in face.
Using method: after clean, gets appropriate embodiment 1 and prepares sample and spread upon affected part, be massaged into gently and absorb completely, and twice daily, using for 1 course for the treatment of continuously, 4 weeks is a course for the treatment of.
Curative effect: skin lesion counting × 100% before curative effect=(before treatment the rear skin lesion counting of skin lesion counting-treatment)/treatment
Effective: skin lesion disappears 60% ~ 90%, and symptom alleviates;
Effective: skin lesion disappears 20% ~ 60%, symptom is improved;
Invalid: skin lesion disappears < 20%, and clinical symptoms is not improved;
(1) pimple
As shown in Figure 4, after sample uses first week, its action effect for pimple is obvious, and the lasts in 1 ~ 3 three week is good.
(2) pustule
As shown in Figure 5, after sample uses 2 weeks, the action effect for pustule of sample is obvious, and has lasting lasting effect.
(3) pockmark
As shown in Figure 10, after sample uses 4 weeks, sample prevents the generation action effect of pockmark obvious.
(4) conclusion
Comprehensive above test result draws, its volunteer is after being use sample:
1) from the intuitive visual index of skin: pimple, pustule, pockmark judge, the state that can significantly improve purported skin of its sample sets, the prolongation of the time used with volunteer, it improves effect gradually in increasing trend.
2) as shown in Fig. 6 to 9, from volunteer self sensation aspect, along with the increase of the time used, its volunteer feels particularly evident, the effect having certain anti-acne, prevent pockmark from producing, wherein cut-off detects last week, and namely the volunteer of 4th week feels that efficiently individual quantity reaches 89%.
Claims (8)
1. have a skin care compositions for acne-removing, it is characterized in that, described skin care compositions comprises the raw material of following weight percentage ratio:
Described antipruritic and antipruritic agent II is water/glycerol/trehalose/tapioca/Opuntia Streptacantha stem extract;
Described Chinese medicine extract is obtained through the extraction of field of Chinese medicines general extraction methods by the crude drug of following weight:
Herba Artemisiae Scopariae 20 ~ 30, the Fructus Kochiae 10 ~ 30, Cortex Moutan 10 ~ 20, Galla Chinensis 10 ~ 20, Spina Gleditsiae 10 ~ 20 and Spica Prunellae 10 ~ 20.
2. skin care compositions as claimed in claim 1, is characterized in that, described Chinese medicine extract is obtained through following method extraction by the crude drug of following weight:
(1) according to following weight parts proportioning weighting raw materials:
Herba Artemisiae Scopariae 20 ~ 30, the Fructus Kochiae 20 ~ 30, Cortex Moutan 10 ~ 20, Galla Chinensis 10 ~ 20, Spina Gleditsiae 10 ~ 20 and Spica Prunellae 10 ~ 20;
(2) percent by volume is 75% ~ 80% ethanol extraction twice, and it is 1:10 ~ 1:20 that first time extracts crude drug and ethanol mass volume ratio g/ml, 60 DEG C ~ 70 DEG C heated and stirred 1 ~ 2 hour, filters to obtain filtrate for the first time; Second time extracts crude drug and ethanol mass volume ratio g/ml is 1:10 ~ 1:20,60 DEG C ~ 70 DEG C heated and stirred 30min ~ 60min, filters to obtain second time filtrate; First time, filtrate mixed with second time filtrate, and rotary evaporation is concentrated into 0.2g/ml ~ 0.5g/ml, obtains concentrate;
(3) add propylene glycol or butanediol, sucking filtration, 3000 ~ 5000 revs/min of centrifuging and taking supernatant according in the mass ratio concentrate that to be 1:1 ~ 1:2 obtain to step (2), collect filtrate, to obtain final product.
3. skin care compositions as claimed in claim 1 or 2, it is characterized in that, described skin care compositions also comprises C phase, and described C phase and consumption are: antiseptic 0.01 ~ 0.5wt%.
4. a preparation method for skin care compositions described in claim 1 or 2, is characterized in that, described preparation method comprises the steps:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA and allantoin are added to the water be heated to 80 DEG C ~ 90 DEG C after stirring and evenly mixing cooling;
(2) cool to less than 40 DEG C, add Chinese medicine extract and stir, to obtain final product.
5. a preparation method for skin care compositions described in claim 3, is characterized in that, the step of described preparation method is as follows:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA and allantoin are added to the water be heated to 80 DEG C ~ 90 DEG C after stir cooling;
(2) cool to less than 40 DEG C, add antiseptic and Chinese medicine extract stirs, to obtain final product.
6. have a skin care formulation for acne-removing, it is characterized in that, described skin care formulation is made up of preparation method described in claim 4.
7. have a skin care formulation for acne-removing, it is characterized in that, described skin care formulation is made up of preparation method described in claim 5.
8. the skin care formulation with acne-removing as claimed in claims 6 or 7, it is characterized in that, described skin care formulation is water preparation.
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| CN105193649B (en) * | 2015-05-28 | 2018-04-10 | 孟宏 | With radiation proof and repair the external skin-care composition of skin barrier effect, toner and preparation method thereof |
| CN105194286B (en) * | 2015-05-28 | 2019-03-01 | 孟宏 | Have effects that radiation protection and repair the external skin-care composition of skin barrier, essence and preparation method thereof |
| CN105168478A (en) | 2015-08-28 | 2015-12-23 | 无限极（中国）有限公司 | Skin care product and preparation method thereof |
| CN105168479A (en) * | 2015-08-28 | 2015-12-23 | 无限极（中国）有限公司 | Acne-removing traditional Chinese medicine composition and preparation method thereof |
| CN105078838A (en) * | 2015-09-10 | 2015-11-25 | 柳超 | Acne-removing lotion and preparation method thereof |
| CN106381125B (en) * | 2016-08-26 | 2021-03-30 | 华南理工大学 | Chinese herbal medicine extract and application thereof in preparation of gas hydrate with high gas storage density |
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| CN108113956A (en) * | 2018-03-05 | 2018-06-05 | 广州市尚昇生物科技有限公司 | A kind of acne removing water and its preparation method and application |
| CN108815035A (en) * | 2018-07-29 | 2018-11-16 | 佛山文森特知识产权服务有限公司 | A kind of refrigerant itching relieving skin care composition |
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| CN103202797A (en) | 2013-07-17 |
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