CN108186510A - A kind of aloe oil control and acne removal composition - Google Patents
A kind of aloe oil control and acne removal composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of oil control and acne removal compositions, contain raw material as described below:Chicory root extract, ginseng extract, aloe extract and peony root extractive.The chicory root extract, ginseng extract, aloe extract and peony root extractive mass ratio be (1~10):(1~10):(1~10):(1~10).Oil control and acne removal composition of the present invention can be absorbed through skin very well, by dredging pore, inhibiting bacteria and diminishing inflammation, Sage Extract, the approach to boost metabolism, play effective anti-acne effect, and be effectively improved the pigmentation at small pox position.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of aloe oil control and acne removal composition.
Background technology
Acne, popular name whelk are a kind of inflammatory disorders for being happened at pilosebaceous follicle and its surrounding tissue.The hair of acne
It is raw mainly closely related with the factors such as hypersteatosis, pilosebaceous duct obstruction, bacterium infection and inflammatory reaction.
The pathogenesis of acne vulgaris is:Facial sebum secretion increases, and leads to hair follicle and sebaceous gland duct hyperkeratinization.Hyperkeratinization
Cell and sebum combine, and deposit and form fat granule in hair follicle, and fat granule is decomposed by the propionibacterium acnes in hair follicle, generate free
Aliphatic acid causes inflammation to form acne.Propionibacterium acnes are can be seen that from the pathogenesis of acne
(Propionibacteriumacnes) it is the finally formed key factor of acne and essential condition, in the formula of cosmetics
If can add certain active constituents effectively inhibits or kill propionibacterium acnes in design, expected anti-acne effect can be reached
Fruit.
At present, the product for the treatment of acne is added to chemical bactericide, hormone, astringent and anti-inflammatory agent etc. more in the market, though
It can sterilize in a short time or anti-inflammatory, but big to skin irritation, the burden that can increase skin be used for a long time, and cause skin red
The allergic symptoms such as swollen, suppuration or pain, and since pathogen easily generates drug resistance, acne will soon recur, and be formed
Scar or pigmentation.Antibiotic and hormonal substance are big since side effect is used for a long time, disabled.In addition, in some
Medicine acne-eliminating cosmetic due to the mechanism of action and ingredient collocation it is indefinite product is caused to work slow, treatment cycle is long, there have to be unpleasant more
Smell and color can also leave black or Red Sigil, also do not welcome by consumer after healing.Therefore, research and development are a kind of more
Safe efficient, lasting product for resolving poxes is particularly urgent.
Invention content
The technical problem to be solved in the present invention is to provide a kind of oil control and acne removal composition is provided, skin quilt can be penetrated well
It absorbs, by dredging pore, inhibiting bacteria and diminishing inflammation, Sage Extract, the approach to boost metabolism, plays effective anti-acne effect, and
It is effectively improved the pigmentation at small pox position.
In order to achieve the above object, the present invention provides following technical solution:
A kind of oil control and acne removal composition, contains raw material as described below:Chicory root extract, ginseng extract, aloe carry
Take object and peony root extractive.
In wherein some embodiments, the chicory root extract, ginseng extract, aloe extract and tree peony root carry
The mass ratio for taking object is (1~10):(1~10):(1~10):(1~10).
In wherein some embodiments, the oil control and acne removal composition also contains raw material as described below:Radix sophorae carries
Take object, kaempferia galanga root extract, Radix Arnebiae extract, Radix Salviae Miltiorrhizae root extract and Rhizoma Atractylodis Macrocephalae root extract, the kuh-seng root extract, mountain
A kind of apple root extract, Radix Arnebiae extract, Radix Salviae Miltiorrhizae root extract and Rhizoma Atractylodis Macrocephalae root extract mass ratio be (1~10):(1~10):
(1~10):(1~10):(1~10).
Oil control and acne removal composition of the present invention can be used as a kind of functional additive to add in the common base of cosmetics
In matter or carrier, wherein the cosmetics are facial mask, cream, gel, lotion, Essence, spraying, toner etc., and changing
Additive amount in cosmetic is 0.1%~1%.
In addition, the present invention also provides a kind of Whelk-eliminating paste, the component of following mass percent is included:Octyl group polymethyl siloxane
1~5%, Parleam 1~5%, cetostearyl alcohol 1~3%, olive oil 1~2%, dimethyl silicone polymer 1~
2%th, Butyrospermum parkii fruit fat 0.1~1%, polysorbate -600.1~1%, PEG-100 stearates 0.1~0.5%, glycerine
Stearate 0.1~1%, PEG-100 stearates 0.1~1%, frankincense oil 0.01~0.1%, glycerine 1~5%, 1,3-
It is propylene glycol 1~5%, glycerin polyether -261~3%, Sodium Hyaluronate 0.01~0.1%, tocopherol acetate 0.1~1%, sweet
Oily caprylate 0.1~0.5%, dipotassium glycyrrhizinate 0.1~0.5%, 1,2- pentanediols 0.1~1%, acrylic acid (ester) class/C10-
30 alkylol acrylamide acid esters cross-linked polymers 0.1~0.5%, parahydroxyacet-ophenone 0.1~0.5%, triethanolamine 0.1~
0.5%th, xanthans 0.05~0.2%, described above there is composition 0.1~1%, the water surplus of oil control and acne removal.
The fractions of composition are made with following briefly introduction:
Chicory root extract can eliminate freckle, whelk, acne, have instant bactericidal effect and antisepsis, can be with
The acne as caused by propionic acid Propiobacterium and other pathogens is effectively reduced, while also there is potent cell facilitation, it can
It is left no trace simultaneously with dispelling skin acne;Ginseng extract can inhibit the activity of tyrosinase, and then reduce pigmentation, rise
To whitening function;Aloe extract can not only clean skin, moreover it is possible to remove blackhead and acne, and reduce skin itch;Tree peony root
Extract has good antioxidation, can effectively remove free radical, reduces oxidative damage;The present invention is mutual by these four ingredients
Mutually reconcile, collaboration, can realize stripping aging cutin, dredging pore, inhibiting bacteria and diminishing inflammation, adjust water and oil balance, boost metabolism,
The pigmented multiple skin effect caused by whelk is removed, realizes the purpose of anti-acne skin care.In addition, Radix Arnebiae extract is not
Only there are antiallergy, anti-aging effects, also with good moisture-keeping function, and promote the generation of collagen, increase skin
Elasticity;Rhizoma Atractylodis Macrocephalae root extract has good resisting pathogenic microbes effect, maintains the microecological balance of skin surface, and can increase
The antianaphylaxis of skin;Radix Salviae Miltiorrhizae root extract has very strong vasodilative effect, has good treatment to more red blood silks, congested dermatitis
Effect, to eliminating blackening, freckle has extremely strong synergism, and to antifreeze, effect of prestressed is splendid.With kuh-seng root extract, kaempferia galanga
Root extract compounds chicory root extract, ginseng extract, aloe extract and peony root extractive together, can further suppress
Acne and inflammation as caused by propionibacterium acnes and staphylococcus aureus etc., while the pH value of skin microenvironment is adjusted, press down
The growth of acne pathogenic flora processed, while there are good moisture-keeping functions, skin water and oil balance is adjusted, improves environment in skin,
Inhibit the hyperkeratosis of pilosebaceous duct, prevent grease blocked pore from acne being caused to be formed.It can also be formed in skin surface
Hydrated sheath repairs the function barrier of skin while skin care, reduces the formation of depressed scar after acne.
Compared with prior art, it is the device have the advantages that as follows:
Oil control and acne removal composition of the present invention is largely tested and is studied through inventor, selected chicory root extract,
Ginseng extract, aloe extract and peony root extractive are accelerated to solve acne problems in terms of the deep layer mechanism for generating acne,
Depth reparation and the impaired acne skin of nourishing, effectively desalinate acne print pockmark, make the fast quick-recovery original color of acne skin and elasticity,
It can be good at being absorbed through skin surface, into deep layer;The multiple efficacies ingredient being rich in is reconciled mutually, is cooperateed with, can be with
Stripping aging cutin is played, dredging pore, inhibiting bacteria and diminishing inflammation, oil-control, boosts metabolism, remove the pigment caused by whelk and sink
The all-dimensional multi-angle effect, has excellent anti-acne skin effect.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, but the implementation of the present invention is not limited to this, for especially not dated technological parameter or condition, can refer to
Routine techniques carries out.
A kind of Whelk-eliminating paste includes the component of such as the following table 1:
Table 1
Comparative example 1
Difference lies in be not added with chicory root extract with embodiment 3.
Comparative example 2
Difference lies in be not added with ginseng extract with embodiment 3.
Comparative example 3
Difference lies in be not added with aloe extract with embodiment 3.
Comparative example 4
Difference lies in be not added with peony root extractive with embodiment 3.
Comparative example 5
With embodiment 3 difference lies in, chicory root extract in acne-removing composition, ginseng extract, aloe extract and
The mass ratio of peony root extractive is 1:11:1:0.9.
Comparative example 6
Difference lies in be not added with kuh-seng root extract with embodiment 4.
Comparative example 7
Difference lies in be not added with kaempferia galanga root extract with embodiment 4.
Comparative example 8
Difference lies in be not added with Radix Arnebiae extract with embodiment 4.
Comparative example 9
Difference lies in be not added with Radix Salviae Miltiorrhizae root extract with embodiment 4.
Comparative example 10
Difference lies in be not added with Rhizoma Atractylodis Macrocephalae root extract with embodiment 4.
The inhibition of propionibacterium acnes is tested
(1) test specimen:Whelk-eliminating paste, acne propionic acid bar prepared by the Whelk-eliminating paste of Examples 1 to 5 preparation, comparative example 1~10
3 groups of bacteria strain (isolated at patients with acne skin lesion);
(2) test method:
1. the culture of anaerobic bacteria, separation, identification:THl0 cultures will be inoculated at patients with acne skin lesion by isolated sample
In base, with airbag method, 37 DEG C of culture 72h in anaerobic jar are placed in, indicator are made with methylene blue, palladium grain is pierced for catalysis.
2. the separation of anaerobic bacteria
Picking single bacterium colony turns 2 pieces of tablets, and one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition;Another piece
With 37 DEG C of aerobic cultures;Result is observed after 48h.
3. the identification of anaerobic bacteria
Without bacterial growth under aerobic culture;
Occur uniform form, canescence, the circle of tiny, diameter about 1.Omm protrusions, edge on the tablet of Anaerobic culturel
Bacterium colony is made microscopy, visible chromabacterium biolaceum under mirror by slightly neat bacterium colony.It is micro-bend in rodlike or rod-shaped, can one end blunt circle, one end becomes
Carefully, coloring is not deep, and cell is single, can arrange or arrange in pairs as the shapes such as " people ", " v ".Again tested through oxytolerant, catalase test,
Indole test, biochemical serial test for identification are propionibacterium acnes.
4. anaerobism drug sensitive test
Inoculation:1 colony inoculation in the bacterium colony more than picking cultivated is on LB plating mediums, the aerobic trainings of 370C
It supports for 24 hours, by aerobic culture, propionibacterium acnes are rinsed with sterile saline for 24 hours, and flushing liquor is put into sterile test tube;Using wheat
Family name's turbidimetry is than turbid, and opacity tube is with shaking 12 times is before needed, first than turbid to 3 × 108/mL, then with normal saline dilution to 106/mL
It is spare.
LB plating mediums are inoculated with:The swab stick of sterilizing is dipped into bacterium solution, extra bacterium solution is gone in being squeezed on tube wall, is trained in LB tablets
Even spread on base is supported, and a circle is swept along plate edge ring, covers plate, dry 2min.Sterile steel bowl (a diameter of 6mm) is light
It is put on plating medium, fills it up with the prevention acne composition obtained by embodiment, be put into 37 DEG C of aerobic cultures for 24 hours, find plate
Interior no bacterial growth continues 37 DEG C of aerobic cultures and sees have inhibition zone to be formed afterwards for 24 hours.Antibacterial circle diameter is surveyed, by 3 groups of antibacterial circle diameters
Value is averaged.
Result of the test:
Chinese medicine antibacterial susceptibility grade classification, with reference to corresponding antibiotic standard ".Inhibition zone diameter>20mm is Gao Min, 10~
20mm is quick in being,<10mm is drug resistance, and the results are shown in Table 2 for specific observation.
Table 2
The Whelk-eliminating paste that can be seen that Examples 1 to 5 preparation from the result of the test of table 2 is respectively provided with high quick effect (inhibition zone is straight
Diameter>20mm), and comparative example 1~5 prepare Whelk-eliminating paste only have in quick effect (10~20mm of antibacterial circle diameter).Illustrate witloof
Root extract, ginseng extract, aloe extract and peony root extractive can be synergistic, have excellent inhibiting bacteria and diminishing inflammation work(
Effect.
Embodiment 4-5 and embodiment 1-3 is compared as it can be seen that kuh-seng root extract, kaempferia galanga root extract, Radix Arnebiae extract, pellet
The addition of ginseng root extract and Rhizoma Atractylodis Macrocephalae root extract significantly improves inhibition of the Whelk-eliminating paste to propionibacterium acnes;
And comparative example 6-10 and embodiment 4-5 is compared as it can be seen that kuh-seng root extract, kaempferia galanga root extract, Radix Arnebiae extract, red sage root
Extract and Rhizoma Atractylodis Macrocephalae root extract can just embody promotion effect when sharing, and have the function of synergy.
Oil-control efficacy validation
First, tested crowd
300 adult female volunteers, age between 16 to 35 one full year of life, are randomly divided into 15 groups;
2nd, test method
Left and right sides at cheek, temple and corners of the mouth intersection at experiment septum reset or so cheekbone, nose and pupil intersection or so
As test area.Specification subject or care-giver adhere to using daily sooner or later, half face test sample, and another half face only makes
It is wiped with clear water.Carry out follow-up within 1 week, 2 weeks after experiment starts, the Whelk-eliminating paste that test is prepared using Examples 1 to 5 respectively, comparison
Whelk-eliminating paste and the skin oil and fat changes of contents using clear water prepared by example 1~10, the test of same volunteer is by same survey
Amount personnel complete.
3rd, search time
Entirely 4 weeks by a definite date researchers of research carried out clinical test results in the 0th week, 2 weeks, 4 weeks, variation in 2 weeks, variation in 4 weeks
Assessment.Oil-control test result is shown in Table 3.
4th, testing standard
The measure of skin oil and fat content
3 are surveyed using the skin oil and fat content measuring instrument Sebumeter that German Courage+Khazaka (CK) company produces
It is secondary to be averaged.
Table 3
The oil-control performance that can be seen that the Whelk-eliminating paste of Examples 1 to 3 preparation from the data result of table 3 is apparently higher than comparison
The oil-control performance of Whelk-eliminating paste prepared by example 1~5.Illustrate that chicory root extract, ginseng extract, aloe extract and tree peony root carry
Take the key component that object is Whelk-eliminating paste performance oil-control effect, and chicory root extract, ginseng extract, aloe extract and tree peony
The effect of Whelk-eliminating paste is just apparent when root extract shares, and embodies synergistic function.
Embodiment 4-5 and embodiment 1-3 is compared as it can be seen that kuh-seng root extract, kaempferia galanga root extract, Radix Arnebiae extract, pellet
The addition of ginseng root extract and Rhizoma Atractylodis Macrocephalae root extract significantly improves the oil-control effect of the Whelk-eliminating paste;And comparative example 6-10 with
Embodiment 4-5 is compared as it can be seen that kuh-seng root extract, kaempferia galanga root extract, Radix Arnebiae extract, Radix Salviae Miltiorrhizae root extract and Rhizoma Atractylodis Macrocephalae root carry
It takes object that can just embody promotion effect when sharing, there is synergy.
Human efficiency evaluates
Object on probation:The crowd of 20-45 Sui face head's small pox of age, facial skin status and appearance for greasy, pigmentation,
Cutin aging.
Method:Every group of 20 people, anti-acne prepared by the Whelk-eliminating paste and comparative example 1~10 that respectively prepared by test example 1~5
Cream.Corresponding product is tested twice sooner or later daily, and other product for resolving poxes or hormone product must not be used during experiment,
In the state of the 25th day detection skin, as a result such as the following table 4.
Table 4
As can be seen from Table 4, the Whelk-eliminating paste that prepared by Examples 1 to 5 is above comparative example 1~5 to the improvement of skin.
Illustrate that chicory root extract, ginseng extract, aloe extract and peony root extractive effectively play stripping aging cutin, control
Oil removes the effect of the all-dimensional multi-angles such as the pigmentation caused by whelk, has excellent anti-acne skin effect, and witloof
The effect of Whelk-eliminating paste is just apparent when root extract, ginseng extract, aloe extract and peony root extractive share, and embodies association
Same synergistic effect.
Embodiment 4-5 and embodiment 1-3 is compared as it can be seen that kuh-seng root extract, kaempferia galanga root extract, Radix Arnebiae extract, pellet
The addition of ginseng root extract and Rhizoma Atractylodis Macrocephalae root extract significantly improves the greasy of the Whelk-eliminating paste, pigmentation, cutin aging
Effect;And comparative example 6-10 and embodiment 4-5 is compared as it can be seen that kuh-seng root extract, kaempferia galanga root extract, Radix Arnebiae extract, pellet
Ginseng root extract and Rhizoma Atractylodis Macrocephalae root extract can just embody improvement when sharing, and have the function of synergy.
The above described is only a preferred embodiment of the present invention, limitation in any form is not done to the present invention, therefore
All contents without departing from technical solution of the present invention, technical spirit according to the present invention is made to the above embodiment any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (7)
1. a kind of oil control and acne removal composition, which is characterized in that the oil control and acne removal composition contains raw material as described below:Chrysanthemum
Lettuce root extract, ginseng extract, aloe extract and peony root extractive.
2. a kind of oil control and acne removal composition according to claim 1, which is characterized in that the chicory root extract, people
The mass ratio of conopsea extraction, aloe extract and peony root extractive is (1~10):(1~10):(1~10):(1~10).
A kind of 3. oil control and acne removal composition according to claim 1 or 2, which is characterized in that the oil control and acne removal combination
Object also contains raw material as described below:Kuh-seng root extract, kaempferia galanga root extract, Radix Arnebiae extract, Radix Salviae Miltiorrhizae root extract and white
Art root extract, the kuh-seng root extract, kaempferia galanga root extract, Radix Arnebiae extract, Radix Salviae Miltiorrhizae root extract and Rhizoma Atractylodis Macrocephalae root carry
The mass ratio for taking object is (1~10):(1~10):(1~10):(1~10):(1~10).
4. a kind of oil control and acne removal composition according to claim 3, which is characterized in that the oil control and acne removal composition is made
It is that a kind of functional additive is added in the common matrix of cosmetics or carrier.
5. a kind of oil control and acne removal composition according to claim 4, which is characterized in that the cosmetics for facial mask, cream,
Gel, lotion, Essence, spraying, toner.
6. a kind of oil control and acne removal composition according to claim 5, which is characterized in that the oil control and acne removal composition exists
Additive amount in cosmetics is 0.1%-1%.
7. a kind of Whelk-eliminating paste, which is characterized in that include the component of following mass percent:Octyl group polymethyl siloxane 1~5%,
Parleam 1~5%, cetostearyl alcohol 1~3%, olive oil 1~2%, dimethyl silicone polymer 1~2%, ox
Oily fruit tree fruit fat 0.1~1%, polysorbate -600.1~1%, PEG-100 stearates 0.1~0.5%, glycerol stearate
Ester 0.1~1%, PEG-100 stearates 0.1~1%, frankincense oil 0.01~0.1%, glycerine 1~5%, 1,3- propylene glycol 1~
5%th, glycerin polyether -261~3%, Sodium Hyaluronate 0.01~0.1%, tocopherol acetate 0.1~1%, glycerol caprylate
0.1~0.5%, dipotassium glycyrrhizinate 0.1~0.5%, 1,2- pentanediols 0.1~1%, acrylic acid (ester) class/C10-30 alkanols third
Olefin(e) acid ester cross-linked polymer 0.1~0.5%, parahydroxyacet-ophenone 0.1~0.5%, triethanolamine 0.1~0.5%, xanthans
0.05~0.2%, claim 1-3 any one of them has effects that composition 0.1-1%, the water surplus of oil control and acne removal.
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CN113116763B (en) * | 2019-12-31 | 2023-10-27 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, repairing cream containing collagenase inhibitor and preparation method of repairing cream |
CN113368018A (en) * | 2020-03-10 | 2021-09-10 | 盈妆生物科技(上海)有限公司 | Anti-inflammatory acne-removing composition and preparation method thereof |
CN112426390A (en) * | 2020-12-22 | 2021-03-02 | 广州天翼化妆品有限公司 | Natural traditional Chinese medicine acne-removing composition and preparation method thereof |
WO2022173787A1 (en) * | 2021-02-15 | 2022-08-18 | Lincoln Manufacturing Inc | Multifunctional natural protectant systems with hydroxyacetophenone |
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