CN110420266A - A kind of three green pepper anti-acne anti-mite agent - Google Patents

A kind of three green pepper anti-acne anti-mite agent Download PDF

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CN110420266A
CN110420266A CN201910737287.9A CN201910737287A CN110420266A CN 110420266 A CN110420266 A CN 110420266A CN 201910737287 A CN201910737287 A CN 201910737287A CN 110420266 A CN110420266 A CN 110420266A
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acne
mite agent
extract
kawakaw
mite
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CN110420266B (en
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林助鸣
陈超炉
林圣伟
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Guangzhou Chuanyan Chemical Technology Co Ltd
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Guangzhou Chuanyan Chemical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/67Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/758Zanthoxylum, e.g. pricklyash
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The invention discloses a kind of three green pepper anti-acne anti-mite agent, mainly contain Chinese prickly ash (ZANTHOXYLUM BUNGEANUM) berry extract, millet starch (CAPSICUM FRUTESCENS) berry extract, kawakaw (PIPER METHYSTICUM) root extract.Three greens pepper acne-removing composition of the present invention can reduce fat secretion, guarantee that cuticula falls off normally, and also have good anti-mite effect, the problem of can effectively solve whelk recurrent exerbation.

Description

A kind of three green pepper anti-acne anti-mite agent
Technical field
The present invention relates to anti-acne anti-mite products, are specifically related to a kind of three green pepper anti-acne anti-mite agent.
Background technique
1841, mankind vermiform mite worm was found in people's external auditory canal by Berger earliest, was then presented as secrecy report Give Paris academy of sciences;1842, G Simon published thesis in Berlin, is described in detail in find in human face's hair follicle this and posts Infested is mite, and is called steatozoons.Later, constantly there are relevant research and discovery.1919, Stanley Hirst was first The secondary monograph published about Demodex describes known 24 kinds of vermiform mites at that time.1972, C Desch and NB Mankind vermiform mite worm is classified as demodex folliculorum and demodex brevis by Nutting.Mankind vermiform mite worm is found 177 years so far Come, although not interrupted always to the researchs such as its biology, immunology, epidemiology, pathogenic, treatment method, due to doctor Fatal disease will not generally be developed into clinical disease by treating bound pair demodicidosis ununified understanding and demodicidosis Disease, or even many medical workers are additionally considered that mankind vermiform mite worm is exactly the non-pathogenic helminth of human normal.So that we Medical text books do not discuss clearly, have less understanding after causing medico from one generation to the next to go on clinical position to it. In face of whelk (acne), the acarodermatitis such as brandy nose, pore be coarse, blackhead, the change of skin orange peel, flush Clinical manifestation, if treated still according to traditional fuzzy cause of disease, this results in clinically not curing acarodermatitis, And there is basic reason repeatedly (referring to the clinical research of Pu Xingwang, Liu Gang, Lu Kaihua mankind vermiform mite worm and skin health Be in progress [J] China drainer for plastic surgery magazine, 2018,29 (08): 510-511+516-517.)
Therefore, market in urgent need one kind had not only had anti-acne effect, but also the product with mite removal effect, was sent out repeatedly with solving whelk Make, it is difficult to the problem of eradicating.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of product for resolving poxes for having both mite removal effect, can effectively solve the youth The problem of acne recurrent exerbation.
The specific technical solution to solve the above problems is as follows:
A kind of three green pepper anti-acne anti-mite agent, contain Chinese prickly ash (ZANTHOXYLUM BUNGEANUM) berry extract, millet starch (CAPSICUM FRUTESCENS) berry extract, kawakaw (PIPER METHYSTICUM) root extract.
Three greens pepper anti-acne anti-mite agent of the present invention can be prepared by conventional production process, in preferable implementation of the invention In mode comprising following steps:
(1) Chinese prickly ash fruit, millet starch fruit, kawakaw root dry, pulverize to 10-50 mesh, obtains plant powder;
(2) water, butanediol, hexylene glycol are added into plant powder to extract as Extraction solvent, then filters.
In wherein some embodiments, in the step (2), extracts preferred cryogenic high pressure difference method and extract, including walk as follows Rapid: by plant powder and solvent, investment is extracted in kettle together after mixing, and temperature is adjusted to 30 ~ 50 DEG C, it is forced into 50 ~ 100MPa, stirs lower soak extraction 10 ~ 30 minutes, is then centrifuged for, then collection supernatant is separated by filtration.
In wherein some embodiments, the Chinese prickly ash fruit, millet starch fruit, kawakaw root mass ratio be (1- 10): (1-10): (1-10).
The mass ratio of Chinese prickly ash fruit, millet starch fruit, kawakaw root described in one of the embodiments, is 1:2:1.
In wherein some embodiments, the mass ratio of the plant powder and water, butanediol, hexylene glycol is 1:15: 5:0.5。
The present invention uses the characteristics of cryogenic high pressure difference method to be to be avoided that the loss of heat-sensitive ingredients, high-pressure section under cryogenic conditions Solvent is easier to penetrate into inside plant powder under part, is quickly soluble in effective component in solvent, and test proves, passes through low temperature The extract active constituent that High Pressure Difference method obtains is higher, and skin-care effect is more preferably.
Three greens pepper acne-removing composition of the present invention can reduce fat secretion, guarantee that cuticula falls off normally, and also With good anti-mite effect, the problem of can effectively solve whelk recurrent exerbation, can be used as a kind of activated feedstock and be added to The common matrix of skin care item or carrier can be made into anti-acne cream, anti-acne essence, anti-acne aqua, anti-acne jelly, Deacne pack, dispel The cosmetics such as acne is spraying, acarid of dispelling is spraying.
In wherein some embodiments, usage amount of the three green pepper acne-removing compositions in cosmetics is 1-10wt%.
The embodiment of the invention also provides a kind of oil control and acne removal frost, the component including following mass percentage:
In wherein some embodiments, the oil control and acne removal frost also contains the extraction of kuh-seng (SOPHORA ANGUSTIFOLIA) root Object.
Kuh-seng (SOPHORA ANGUSTIFOLIA) root extract of the present invention can be marketable material, be also possible to Be made by conventional method, such as: be solvent with water or ethyl alcohol, extract 1-3 time, combined extract, filter to get.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to Routine techniques carries out.
Chinese prickly ash fruit according to the present invention, to A type and beta streptococcus, staphylococcus, pneumococcus, bacillus anthracis, withered Straw bacterium, comma bacillus, proteus, paratyphosum Bacterium, shigella dysenteriae, Pseudomonas aeruginosa have inhibiting effect.Volatile oil is to thin Bacterium and a variety of dermatophytes and deep fungal have certain bacteriostasis, wherein to wool sample sporidiole bacteria and red hair tinea Bacterium is most sensitive.Skimmianine also has stronger antifungic action.Contained volatile oil can make ascaris suum seriously be poisoned in ringer solution, right Itch mite has stronger action of contace poison.
Millet starch fruit according to the present invention, to many strains such as gold-coloured staphylococci, Fu Shi dysentery bacterium, typhoid fever dysentery bacterium, green Purulence bacillus, withered grass bacterium etc. have the killing effect of inhibition, while can also accelerate blood circulation, promote red blood cell liveness, accelerate Skin metabolism helps impaired organization healing and consolidation skin, can promote close connection between epidermis and corium and It can inhibit the increase of fat cell.
Kawakaw root according to the present invention contains a variety of amides compounds: such as piperine, piperamide, piperettine Alkali, papper oil alkali, aromatic oil, crude protein etc. compound are directed to the propionibacterium acnes of small pox, pseudomonas aeruginosa, and white is read Pearl bacterium and staphylococcus have extraordinary sterilization analgesic activity.
Radix sophorae according to the present invention, rich in matrine, oxymatrine, ammothamnine, N-Methylcytisine, The alkaloids such as Anagyrine, baptifoline, SopHocarpine, d-Iosmatrine, Kuraridine have anti-inflammation and sterilization antibacterial, adjust Immune and increasing leukocyte and Bergamot Mint Extract.
Embodiment 1
A kind of preparation method of three greens pepper anti-acne anti-mite agent, comprising the following steps:
(1) Chinese prickly ash fruit, millet starch fruit, kawakaw root is dry, wherein the Chinese prickly ash fruit, millet starch fruit, kawakaw root Mass ratio be 1:10:1;50 mesh are crushed to, plant powder is obtained;
(2) water, butanediol, hexylene glycol are added into plant powder, wherein the plant powder and water, butanediol, hexylene glycol Mass ratio be 1:15:5:0.5;Investment is extracted in kettle together after mixing, and temperature is adjusted to 30 DEG C, is forced into 50MPa is stirred lower soak extraction 30 minutes, is then centrifuged for, collects supernatant, then with the separation of 1000 mesh filter-cloth filterings.
Embodiment 2
A kind of preparation method of three greens pepper anti-acne anti-mite agent, comprising the following steps:
(1) Chinese prickly ash fruit, millet starch fruit, kawakaw root is dry, wherein the Chinese prickly ash fruit, millet starch fruit, kawakaw root Mass ratio be 10:1:10;10 mesh are crushed to, plant powder is obtained;
(2) water, butanediol, hexylene glycol are added into plant powder, wherein the plant powder and water, butanediol, hexylene glycol Mass ratio be 1:15:5:0.5;Investment is extracted in kettle together after mixing, and temperature is adjusted to 50 DEG C, is forced into 100MPa is stirred lower soak extraction 10 minutes, is then centrifuged for, collects supernatant, then with the separation of 500 mesh filter-cloth filterings.
Embodiment 3
A kind of preparation method of three greens pepper anti-acne anti-mite agent, comprising the following steps:
(1) Chinese prickly ash fruit, millet starch fruit, kawakaw root is dry, wherein the Chinese prickly ash fruit, millet starch fruit, kawakaw root Mass ratio be 1:2:1;30 mesh are crushed to, plant powder is obtained;
(2) water, butanediol, hexylene glycol are added into plant powder, wherein the plant powder and water, butanediol, hexylene glycol Mass ratio be 1:15:5:0.5;Investment is extracted in kettle together after mixing, and temperature is adjusted to 40 DEG C, is forced into 80MPa is stirred lower soak extraction 20 minutes, is then centrifuged for, collects supernatant, then with the separation of 800 mesh filter-cloth filterings.
Comparative example 1
A kind of preparation method of three greens pepper anti-acne anti-mite agent, comprising the following steps:
(1) Chinese prickly ash fruit is crushed to 30 mesh, obtains plant powder;
(2) water, butanediol, hexylene glycol are added into plant powder, wherein the plant powder and water, butanediol, hexylene glycol Mass ratio be 1:15:5:0.5;Investment is extracted in kettle together after mixing, and temperature is adjusted to 40 DEG C, is forced into 80MPa is stirred lower soak extraction 20 minutes, is then centrifuged for, collects supernatant, then with the separation of 800 mesh filter-cloth filterings.
Comparative example 2
A kind of preparation method of three greens pepper anti-acne anti-mite agent, comprising the following steps:
(1) millet starch fruit powder is broken to 30 mesh, obtains plant powder;
(2) water, butanediol, hexylene glycol are added into plant powder, wherein the plant powder and water, butanediol, hexylene glycol Mass ratio be 1:15:5:0.5;Investment is extracted in kettle together after mixing, and temperature is adjusted to 40 DEG C, is forced into 80MPa is stirred lower soak extraction 20 minutes, is then centrifuged for, collects supernatant, then with the separation of 800 mesh filter-cloth filterings.
Comparative example 3
A kind of preparation method of three greens pepper anti-acne anti-mite agent, comprising the following steps:
(1) kawakaw root is crushed to 30 mesh, obtains plant powder;
(2) water, butanediol, hexylene glycol are added into plant powder, wherein the plant powder and water, butanediol, hexylene glycol Mass ratio be 1:15:5:0.5;Investment is extracted in kettle together after mixing, and temperature is adjusted to 40 DEG C, is forced into 80MPa is stirred lower soak extraction 20 minutes, is then centrifuged for, collects supernatant, then with the separation of 800 mesh filter-cloth filterings.
Comparative example 4
A kind of preparation method of three greens pepper anti-acne anti-mite agent, comprising the following steps:
(1) Chinese prickly ash fruit, millet starch fruit, kawakaw root is dry, wherein the Chinese prickly ash fruit, millet starch fruit, kawakaw root Mass ratio be 1:2:1;30 mesh are crushed to, plant powder is obtained;
(2) water, butanediol, hexylene glycol are added into plant powder, wherein the plant powder and water, butanediol, hexylene glycol Mass ratio be 1:15:5:0.5;Investment is extracted in kettle together after mixing, soaking at room temperature extraction 20 minutes under stirring, so After be centrifuged, collect supernatant, then with 800 mesh filter-cloth filterings separation.
Test the test of 1 anti-mite
(1) acquisition of human Demodex: vermiform mite is obtained using Transparent spinel, specific steps: before advising subject to sleep After washing one's face, by long 6cm, the adhesive tape of wide 1.5cm is affixed on the positions such as volume, cheek, nose, chin respectively, morning next day take off after stick at Adhesive tape, microscopy.
(2) it test grouping: takes water as a solvent, is respectively diluted to extract obtained by embodiment 1-3 and comparative example 1-4 1% dilution, and blank control is set.200 microlitres of 1% dilution is added dropwise in each glass slide, spreads out dilution uniformly, guarantees dilute Liquid is released to come into full contact with polypide.It is placed in the environment that relative humidity is 70-80%, temperature is 26-28 DEG C, is taken out after 1 hour, shown The survival condition of micro- microscopic observation vermiform mite.3min is observed continuously under 400 × microscope, polypide huge legendary turtle limb or the sufficient motionless person of pawl sentence Break as death.It specifically tests several such as the following table 1.
1 anti-mite test recording table of table
Seen from table 1, anti-mite effect is best when Chinese prickly ash fruit, millet starch fruit, kawakaw root share.
Embodiment 4
A kind of oil control and acne removal frost, the component including following mass percentage:
Embodiment 5
A kind of oil control and acne removal frost, the component including following mass percentage:
Embodiment 6
A kind of oil control and acne removal frost, the component including following mass percentage:
Embodiment 7
A kind of oil control and acne removal frost, the component including following mass percentage:
Kuh-seng (SOPHORA ANGUSTIFOLIA) root extract of the present invention is made by the following method, such as: it uses 75vt% ethyl alcohol is solvent, stir it is lower extract 3 times, combined extract, filtering to get.
Test the test of 2 oil control and acne removals
The assessment of oil-control effect is carried out to oil control and acne removal frost obtained by embodiment 4-7 and blank control group.Wherein blank control group Difference with embodiment 6 is without containing three green pepper anti-acne anti-mite agent.
Test equipment: German CK company skin oil and fat tester Sebumeter SM815.Its working principle is to use A kind of special adhesive tape, can quickly absorb keratoderma surface grease, and grease can make the light transmittance of adhesive tape change, pass through instrument The light transmittance before and after photometer measurement adhesive tape use built in device and the fat content for obtaining keratoderma.
Test method: convening 40 Oilys and the volunteer with whelk, is divided into 4 groups, every group of 10 people are early daily Evening respectively uses an oil control and acne removal frost, and usage amount is 0.1g/ times, is applied on the face, is gently massaged into absorption.It took pictures every 1 week Recording an anti-acne situation, (by comparing with the photo before product is used, the judgement that whelk quantity reduces 1/3 or more is to have Effect), and the fat content at volunteer's forehead position is measured with skin oil and fat tester, each site tests 3 times are averaged.
Specific test record such as the following table 2, table 3.
2 oil-control test recording table of table
3 anti-acne test recording table of table
From table 2, table 3 as it can be seen that oil control and acne removal frost obtained by the embodiment of the present invention has good oil control and acne removal effect.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.

Claims (9)

1. a kind of three green pepper anti-acne anti-mite agent, which is characterized in that containing Chinese prickly ash (ZANTHOXYLUM BUNGEANUM) berry extract, Millet starch (CAPSICUM FRUTESCENS) berry extract, kawakaw (PIPER METHYSTICUM) root extract.
2. a kind of preparation method of three greens pepper anti-acne anti-mite agent as described in claim 1, which comprises the following steps:
(1) Chinese prickly ash fruit, millet starch fruit, kawakaw root dry, pulverize to 10-50 mesh, obtains plant powder;
(2) water, butanediol, hexylene glycol are added into plant powder to extract as Extraction solvent, then filters.
3. the preparation method of three greens pepper anti-acne anti-mite agent according to claim 2, which is characterized in that in the step (2), mention It takes preferred cryogenic high pressure difference method to extract, includes the following steps: that investment extracts kettle together after mixing by plant powder and solvent In, temperature is adjusted to 30 ~ 50 DEG C, is forced into 50 ~ 100MPa, stirs lower soak extraction 10 ~ 30 minutes, is then centrifuged for, collection Then supernatant is separated by filtration.
4. the preparation method of three greens pepper anti-acne anti-mite agent according to claim 2, which is characterized in that the Chinese prickly ash fruit, small Meter Jiao Guo, kawakaw root mass ratio be (1-10): (1-10): (1-10).
5. the preparation method of three greens pepper anti-acne anti-mite agent according to claim 2, which is characterized in that the Chinese prickly ash fruit, small Meter Jiao Guo, kawakaw root mass ratio be 1:2:1.
6. the preparation method of three greens pepper anti-acne anti-mite agent according to claim 2, which is characterized in that the plant powder with Water, butanediol, hexylene glycol mass ratio be 1:15:5:0.5.
7. application of the three greens pepper anti-acne anti-mite agent described in claim 1 in cosmetics.
8. a kind of oil control and acne removal frost, which is characterized in that the component including following mass percentage:
9. oil control and acne removal frost according to claim 8, which is characterized in that further include kuh-seng (SOPHORA ANGUSTIFOLIA) root extract.
CN201910737287.9A 2019-08-11 2019-08-11 Acne-removing and mite-removing agent with three kinds of pepper Active CN110420266B (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
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CN111329807A (en) * 2020-04-02 2020-06-26 广州市逸轩精细化工有限公司 Acne removing cream and preparation method thereof
CN111617010A (en) * 2020-07-23 2020-09-04 广州市轩颜化妆品有限公司 Foot periostracum and preparation method thereof
CN111991302A (en) * 2020-09-23 2020-11-27 广东大澳生物科技有限公司 Acne removing gel and preparation method thereof
CN112006934A (en) * 2020-09-04 2020-12-01 江苏美爱斯化妆品股份有限公司 Cosmetic compound with mild acne removing effect and application thereof
CN113197804A (en) * 2021-04-29 2021-08-03 钟意生物技术(广州)有限公司 Plant repair factor and application thereof
CN113208992A (en) * 2021-05-11 2021-08-06 广州杨森药业有限公司 Mild acne-removing mite-removing goat milk soap and preparation method thereof
CN115006314A (en) * 2022-07-11 2022-09-06 科乐美(广州)生物科技有限公司 Piper methysticum Forst extract and its preparation method and application
WO2024052756A1 (en) * 2022-09-09 2024-03-14 Crodarom Use of an extract of sichuan pepper for a skin treatment and a composition suitable for this use.
FR3139466A1 (en) * 2022-09-09 2024-03-15 Crodarom Use of a Sichuan pepper extract for skin treatment and a composition adapted to this use.

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