CN109568156A - A kind of antiallergy toner and its preparation method and application containing trollflower - Google Patents
A kind of antiallergy toner and its preparation method and application containing trollflower Download PDFInfo
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- CN109568156A CN109568156A CN201910015370.5A CN201910015370A CN109568156A CN 109568156 A CN109568156 A CN 109568156A CN 201910015370 A CN201910015370 A CN 201910015370A CN 109568156 A CN109568156 A CN 109568156A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
Abstract
The invention belongs to daily skincare product fields, and in particular to a kind of antiallergy toner and its preparation method and application containing trollflower.Antiallergy toner provided by the invention containing trollflower includes following component and its weight percent: Flos Trollii extract 2~5%, Flos Lonicerae extractive solution 1~3%, menthol 0.01~0.05%, propylene glycol 0.01~0.05%, pyrrolidone sodium carboxylate 2~5%, glycerol 2~5%, Sodium Hyaluronate 0.05~0.15%, solubilizer 0.1~0.2%, chamomile essential oil 0.05~0.1%, sweet orange oil 0.1%~0.2%, water 81.45~92.78%.The resistance of skin can be enhanced in antianaphylactic toner provided by the invention, has good antiallergy, anti-inflammatory effect, mildly non-stimulated to skin, makes skin that water be kept to moisten smooth, high resilience.
Description
Technical field
The invention belongs to daily skincare product fields, and in particular to a kind of antiallergy toner and its preparation containing trollflower
Methods and applications.
Background technique
Toner is also referred to as firming lotion, toner etc..The effect of toner, which is that clean again, has restored skin surface
PH-value, and improve cuticula, absorb skin preferably, and prepare for application maintenance product.Absorb skin preferably.
Currently, relative to the skin toner aquatic products containing chemical synthesis ingredient, more and more people tend to using with day
The cosmetic product of right extract component, reason are that natural active matter is mentioned from the natural material of plant, animal or microorganism
It takes and separates, there is the characteristics of widely applicable, without side-effects or Small side effects, more liked by masses, be increasingly becoming master
Stream.And in toner application field, and the product for being provided simultaneously with good anti-allergic effects is even more rare report.
Trollflower also known as " Jin Furong ", " non-irrigated lotus ", " common nasturtium herb " etc., are the rare wild plants of Ranunculaceae Trollius,
It is distributed widely in the ground such as China North China, Inner Mongol and northeast, is herbaceos perennial.Trollius as medicinal origin
Long, it is used as medicine such as trollflower with dry flower or bud, golden yellow color is a kind of civil common herbal medicine in China, first recorded in " book on Chinese herbal medicine
Detailed outline is picked up any lost article from the road ", wherein description has, " trollflower bitter, aphtha, laryngalgia, the larynx cold in nature controlled swell, superficial heat pingival atrophy, ear pain mesh pain, have improving eyesight
The effect of Xie Lan barrier ".And modern pharmacy research shows that, Trollius main component be alkaloid, flavonoids, have more
Anti-inflammatory, it is antiviral the effects of, and have inhibiting effect to various bacteria, wherein trollflower is of great value plants antimicrobial medicine, tool
There is the features such as has a broad antifungal spectrum, effect is significant, adverse reaction is small, medical value is high, widely used.Currently, the research in relation to lily feet
It is concentrated mainly on the Study on Resources, crude drug identifies and acquisition processing, chemical component and active component, preparation research, clinical application etc.
Aspect has already appeared many reports about trollflower related patents, such as trollflower effervescent tablet, Chinese globe flower injection, trollflower
The preparation method of dripping pill, trollflower antipyretic capsule, trollflower freeze-dried powder, Trollflower health-care tea, Trollflower beverage etc., and arrive mesh
Before until, it is rare by Flos Trollii extract be applied to cosmetic field report.
Chinese patent application CN105998215A disclose a kind of Flos Trollii extract and preparation method thereof with containing its preparation,
The Flos Trollii extract is made using in-depth filtration combined flocculation sedimentation, although this method has energy-saving and environmental protection, has
Machine remains low advantage, and still, preparation process is still very complicated；It is that acute and chronic tonsillitis is treated in preparation containing its preparation, it is acute
Tympanitis, acute myringitis, acute conjunctivitis, the drug of acute lymphangitis also include various pharmaceutical carriers in the drug, such as
Polyvinylpyrrolidone, calcium carbonate, superfine silica gel powder etc. can cause certain stimulation to human body.
Chinese patent application CN106389227A discloses a kind of toner, and the toner includes cucumber extract, black
Fructus lycii extracted solution, olive oil can effectively promote the metabolism of body, prevent skin aging, moisten skin whitening, but
It is not include trollflower in the effective component in the toner, might have living contaminants, make one allergy occur, inflammation etc. is asked
Topic, and then stimulation is generated to skin.
In summary, apply trollflower as the seldom of effective component, generally existing anti-mistake in the skin care item of the prior art
The effects of quick, antibacterial anti-inflammatory effect is poor, generates stimulate the reaction to people.
Summary of the invention
The purpose of the present invention is to overcome the shortcomings of the existing technology and deficiency, provides a kind of antiallergy skin toner containing trollflower
Water and the preparation method and application thereof.Antiallergy toner provided by the invention containing trollflower has good antiallergy, anti-inflammatory,
Bacteriostasis efficacy makes skin keep smooth, the high resilience of water profit human temperature and non-stimulated, enhancing skin resistance.
In order to achieve the above object, the technical solution adopted by the present invention are as follows:
A kind of antiallergy toner containing trollflower, including following component and its weight percent: Flos Trollii extract 2~
5%, Flos Lonicerae extractive solution 1~3%, menthol 0.01~0.05%, propylene glycol 0.01~0.05%, nano-titanium dioxide 3%
~5%, pyrrolidone sodium carboxylate 2~5%, glycerol 2~5%, Trenaxmine 1%~2%, Sodium Hyaluronate 0.05~0.15%,
Solubilizer 0.1~0.2%, chamomile essential oil 0.05~0.1%, D-araboascorbic acid 0.1%~0.3%, sweet orange oil 0.1%
~0.2%, water 73.95~88.58%.
Preferably, the antiallergy toner containing trollflower is made of following component and its weight percent: trollflower
Extract 4%, Flos Lonicerae extractive solution 2%, menthol 0.02%, propylene glycol 0.04%, nano-titanium dioxide 4%, pyrrolidones
Carboxylic acid sodium 4%, glycerol 4%, Trenaxmine 1.5%, Sodium Hyaluronate 0.1%, solubilizer 0.15%, chamomile essential oil 0.08%,
D-araboascorbic acid 0.2%, sweet orange oil 0.15%, water 79.76%.
Preferably, the Flos Trollii extract the preparation method comprises the following steps:
(1) trollflower is taken, impurity is washed away, crushed after being dried crosses 80-100 mesh, obtains trollflower coarse powder；
(2) 8-10 times of total amount ethyl alcohol measured of trollflower coarse powder obtained by step (1) is added, adds lily feet obtained by step (1)
The cellulase of flower coarse powder total amount 0.8~1.2%, 2-4h is extracted under conditions of 45-50 DEG C, obtains crude extract；
(3) leaf will be slightly mentioned obtained by step (2) and is warming up to 85-90 DEG C, continue refluxing extraction 3-5h, filtering, and collect filtrate,
Be cooled to 55-65 DEG C, filtrate depressurized, be concentrated into relative density be 1.05-1.15 medicinal extract to get.
Preferably, it is 70- that the ethyl alcohol that step (2) is added in the preparation method of the Flos Trollii extract, which is volume fraction,
80% ethanol solution.
Preferably, the Flos Lonicerae extractive solution the preparation method comprises the following steps: extracting honeysuckle, crushes after cleaning, drying, gold and silver is added
Flower 4-8 times of weight water impregnate 1-2 hours, refluxing extraction 2-3 times is 3-4 hours each, filter, merging filtrate to get.
The preparation method of the present invention also provides the described antiallergy toner containing trollflower, includes the following steps:
S1, by Sodium Hyaluronate, Trenaxmine, nano-titanium dioxide, D-araboascorbic acid and glycerol, be added in agitated kettle,
It mixes slowly uniformly, water is added, is heated to 40-50 DEG C, continue to stir 20-30min, until hyaluronic acid is completely dissolved, it is cooling, it is standby
With；
S2, menthol, chamomile essential oil are taken, sweet orange oil is mixed with Gelfest CH40, is mixed slowly, and is added the third two
Alcohol, homogeneous 5-15min are then added in the agitated kettle of step S1, stir and evenly mix, and obtain mixing liquid；
S3, Flos Trollii extract, Flos Lonicerae extractive solution and pyrrolidones carboxylic is added into mixing liquid obtained by step S2
Sour sodium, mix slowly it is uniform to system, discharging to get.
It preferably, in step S1, S2 and S3 is at a slow speed 50-100r/min.
In the present invention, D-araboascorbic acid and nano-titanium dioxide joined, the two may be combined to form a kind of metatitanic acid class
Substance, this substance can play good sun-proof result, moreover, also there is certain whitening function, meanwhile, the present invention is unexpected
Discovery, Trenaxmine and D-araboascorbic acid be added in a certain amount of ratio, can play better moistening effect.
Compared with prior art, the advantages of the antiallergy toner provided by the invention containing trollflower are as follows:
(1) in the antiallergy toner produced by the present invention containing trollflower, it joined Flos Trollii extract and mentioned with honeysuckle
Liquid is taken, the antibacterial of toner, antiallergy, anti-inflammatory performance are greatly improved；
(2) the antiallergy toner produced by the present invention containing trollflower, while joined Trenaxmine, nano-titanium dioxide,
The substances such as D-araboascorbic acid not only can achieve good moistening effect, can also play certain sun-proof whitening effect；
(3) in the antiallergy toner produced by the present invention containing trollflower, without the chemistry for causing stimulation to human body
Substance will not cause damages to human body, can promote skin resistance, make skin that water be kept to moisten smooth, high resilience.
Specific embodiment
The present invention is further explained combined with specific embodiments below, it is noted that following embodiment is only
To explain the present invention, and it cannot be used to limit the present invention, all technical solutions same or similar with the present invention are in this hair
Within bright protection scope.Unless otherwise specified, what technological means used in embodiment was well known to those skilled in the art
Conventional means, raw materials used is commercial goods.
Gelfest CH40 is purchased from Guangzhou Tuo Xin Chemical Industry Science Co., Ltd；Pyrrolidone sodium carboxylate is purchased from Guangzhou
Quan Ao chemical products Co., Ltd；Menthol is purchased from Zhengzhou Qi Huadun chemical products Co., Ltd；Chamomile essential oil is purchased from
Shanghai Huijia Cosmetics Co., Ltd..
A kind of antiallergy toner containing trollflower of embodiment 1
The antiallergy toner containing trollflower, is made of: Flos Trollii extract following component and its weight percent
2%, Flos Lonicerae extractive solution 1%, menthol 0.01, propylene glycol 0.01, nano-titanium dioxide 3%, pyrrolidone sodium carboxylate 2 is sweet
Oil 2, Trenaxmine 1%, Sodium Hyaluronate 0.05, solubilizer 0.1, chamomile essential oil 0.05, D-araboascorbic acid 0.1%, sweet orange
Essential oil 0.1%, water 88.58%.
The Flos Trollii extract the preparation method comprises the following steps:
(1) trollflower is taken, impurity is washed away, crushed after being dried crosses 80 meshes, obtains trollflower coarse powder；
(2) ethanol solution that trollflower coarse powder 8 times of volume fractions of total amount obtained by step (1) are 70% is added, adds step
Suddenly the cellulase of trollflower coarse powder total amount 0.8% obtained by (1), extracts 2h under conditions of 45 DEG C, obtains crude extract；
(3) leaf will be slightly mentioned obtained by step (2) and be warming up to 85 DEG C, continue refluxing extraction 3h, filtering, and collect filtrate, cool down
To 55 DEG C, filtrate is depressurized, be concentrated into relative density be 1.05 medicinal extract to get.
The Flos Lonicerae extractive solution the preparation method comprises the following steps: extracting honeysuckle, crushes after cleaning, drying, honeysuckle weight 4 is added
Times water impregnate 1 hour, refluxing extraction 2 times, 3 hours every time, filtering, merging filtrate to get.
The antiallergy toner containing trollflower the preparation method comprises the following steps:
S1, by Sodium Hyaluronate, Trenaxmine, nano-titanium dioxide, D-araboascorbic acid and glycerol, be added in agitated kettle,
It is stirred evenly under the speed of 50r/min, water is added, is heated to 40 DEG C, continue to stir 20min, until hyaluronic acid is completely dissolved,
It is cooling, it is spare；
S2, it takes menthol, chamomile essential oil, sweet orange oil to mix with Gelfest CH40, is stirred under the speed of 50r/min
It mixes, propylene glycol is added, homogeneous 5min is then added in the agitated kettle of step S1, stirs and evenly mixs, and obtains mixing liquid；
S3, Flos Trollii extract, Flos Lonicerae extractive solution and pyrrolidones carboxylic is added into mixing liquid obtained by step S2
Sour sodium, under the speed of 50r/min stir it is uniform to system, discharging to get.
A kind of antiallergy toner containing trollflower of embodiment 2
The antiallergy toner containing trollflower, is made of: Flos Trollii extract following component and its weight percent
5%, Flos Lonicerae extractive solution 3%, menthol 0.05%, propylene glycol 0.05%, nano-titanium dioxide 5%, pyrrolidone sodium carboxylate
5%, glycerol 5%, Trenaxmine 2%, Sodium Hyaluronate 0.15%, solubilizer 0.2%, chamomile essential oil 0.1%, the different Vitamin C of D-
Acid 0.3%, sweet orange oil 0.2%, water 73.95%.
The Flos Trollii extract the preparation method comprises the following steps:
(1) trollflower is taken, impurity is washed away, crushed after being dried sieves with 100 mesh sieve, and obtains trollflower coarse powder；
(2) ethanol solution that trollflower coarse powder 10 times of volume fractions of total amount obtained by step (1) are 80% is added, adds step
Suddenly the cellulase of trollflower coarse powder total amount 1.2% obtained by (1), extracts 4h under conditions of 50 DEG C, obtains crude extract；
(3) leaf will be slightly mentioned obtained by step (2) and be warming up to 90 DEG C, continue refluxing extraction 5h, filtering, and collect filtrate, cool down
To 65 DEG C, filtrate is depressurized, be concentrated into relative density be 1.15 medicinal extract to get.
The Flos Lonicerae extractive solution the preparation method comprises the following steps: extracting honeysuckle, crushes after cleaning, drying, honeysuckle weight 8 is added
Times water impregnate 2 hours, refluxing extraction 3 times, 4 hours every time, filtering, merging filtrate to get.
The antiallergy toner containing trollflower the preparation method comprises the following steps:
S1, by Sodium Hyaluronate, Trenaxmine, nano-titanium dioxide, D-araboascorbic acid and glycerol, be added in agitated kettle,
It is stirred evenly under the speed of 100r/min, water is added, is heated to 50 DEG C, continue to stir 30min, until hyaluronic acid is completely molten
Solution, it is cooling, it is spare；
S2, menthol, chamomile essential oil, sweet orange oil is taken to mix with Gelfest CH40, under the speed of 100r/min
Propylene glycol is added in stirring, and homogeneous 15min is then added in the agitated kettle of step S1, stirs and evenly mixs, and obtains mixing liquid；
S3, Flos Trollii extract, Flos Lonicerae extractive solution and pyrrolidones carboxylic is added into mixing liquid obtained by step S2
Sour sodium, under the speed of 100r/min stir it is uniform to system, discharging to get.
A kind of antiallergy toner containing trollflower of embodiment 3
The antiallergy toner containing trollflower, is made of: Flos Trollii extract following component and its weight percent
4%, Flos Lonicerae extractive solution 2%, menthol 0.02%, propylene glycol 0.04%, nano-titanium dioxide 4%, pyrrolidone sodium carboxylate
4%, glycerol 4%, Trenaxmine 1.5%, Sodium Hyaluronate 0.1%, solubilizer 0.15%, chamomile essential oil 0.08%, D- is different to be resisted
Bad hematic acid 0.2%, sweet orange oil 0.15%, water 79.76%.
The Flos Trollii extract the preparation method comprises the following steps:
(1) trollflower is taken, impurity is washed away, crushed after being dried crosses 90 meshes, obtains trollflower coarse powder；
(2) ethanol solution that trollflower coarse powder 9 times of volume fractions of total amount obtained by step (1) are 75% is added, adds step
Suddenly the cellulase of trollflower coarse powder total amount 1.0% obtained by (1), extracts 3h under conditions of 48 DEG C, obtains crude extract；
(3) leaf will be slightly mentioned obtained by step (2) and be warming up to 87 DEG C, continue refluxing extraction 4h, filtering, and collect filtrate, cool down
To 60 DEG C, filtrate is depressurized, be concentrated into relative density be 1.10 medicinal extract to get.
The Flos Lonicerae extractive solution the preparation method comprises the following steps: extracting honeysuckle, crushes after cleaning, drying, honeysuckle weight 6 is added
Times water impregnate 1.5 hours, refluxing extraction 3 times, 3.5 hours every time, filtering, merging filtrate to get.
The antiallergy toner containing trollflower the preparation method comprises the following steps:
S1, by Sodium Hyaluronate, Trenaxmine, nano-titanium dioxide, D-araboascorbic acid and glycerol, be added in agitated kettle,
It is stirred evenly under the speed of 75r/min, water is added, is heated to 45 DEG C, continue to stir 25min, until hyaluronic acid is completely dissolved,
It is cooling, it is spare；
S2, it takes menthol, chamomile essential oil, sweet orange oil to mix with Gelfest CH40, is stirred under the speed of 75r/min
It mixes, propylene glycol is added, homogeneous 10min is then added in the agitated kettle of step S1, stirs and evenly mixs, and obtains mixing liquid；
S3, Flos Trollii extract, Flos Lonicerae extractive solution and pyrrolidones carboxylic is added into mixing liquid obtained by step S2
Sour sodium, under the speed of 75r/min stir it is uniform to system, discharging to get.
A kind of antiallergy toner containing trollflower of comparative example 1
The antiallergy toner containing trollflower, is made of: Flos Trollii extract following component and its weight percent
4%, menthol 0.02%, propylene glycol 0.04%, nano-titanium dioxide 4%, pyrrolidone sodium carboxylate 4%, glycerol 4%, pass it is bright
Acid 1.5%, Sodium Hyaluronate 0.1%, solubilizer 0.15%, chamomile essential oil 0.08%, D-araboascorbic acid 0.2%, sweet orange
Essential oil 0.15%, water 81.76%.
The preparation method of the Flos Trollii extract is similar to Example 3；
The preparation method of the antiallergy toner containing trollflower is similar to Example 3；
Difference with embodiment 3 is, Flos Lonicerae extractive solution is not included in comparative example 1.
A kind of antiallergy toner containing trollflower of comparative example 2
The antiallergy toner containing trollflower, is made of: Flos Trollii extract following component and its weight percent
4%, Flos Lonicerae extractive solution 2%, menthol 0.02%, propylene glycol 0.04%, nano-titanium dioxide 4%, pyrrolidone sodium carboxylate
4%, glycerol 4%, Trenaxmine 1.5%, Sodium Hyaluronate 0.1%, solubilizer 0.15%, chamomile essential oil 0.08%, sweet orange essence
Oil 0.15%, water 79.96%.
The preparation method of the Flos Trollii extract is similar to Example 3；
The preparation method of the Flos Lonicerae extractive solution is similar to Example 3；
The preparation method of the antiallergy toner containing trollflower is similar to Example 3；
Difference with embodiment 3 is, D-araboascorbic acid is not included in comparative example 2.
A kind of antiallergy toner containing trollflower of comparative example 3
The antiallergy toner containing trollflower, is made of: Flos Trollii extract following component and its weight percent
4%, Flos Lonicerae extractive solution 2%, menthol 0.02%, propylene glycol 0.04%, nano-titanium dioxide 4%, pyrrolidone sodium carboxylate
4%, glycerol 4%, Trenaxmine 1.5%, Sodium Hyaluronate 0.1%, solubilizer 0.15%, D-araboascorbic acid 0.2%, sweet orange essence
Oil 0.15%, water 79.84%.
The preparation method of the Flos Trollii extract is similar to Example 3；
The preparation method of the Flos Lonicerae extractive solution is similar to Example 3；
The preparation method of the antiallergy toner containing trollflower is similar to Example 3；
Difference with embodiment 3 is, chamomile essential oil is not included in comparative example 3.
A kind of antiallergy toner containing trollflower of comparative example 4
The antiallergy toner containing trollflower, is made of: Flos Trollii extract following component and its weight percent
4%, Flos Lonicerae extractive solution 2%, menthol 0.02%, propylene glycol 0.04%, pyrrolidone sodium carboxylate 4%, glycerol 4%, pass it is bright
Acid 1.5%, Sodium Hyaluronate 0.1%, solubilizer 0.15%, chamomile essential oil 0.08%, D-araboascorbic acid 0.2%, sweet orange
Essential oil 0.15%, water 83.76%.
The preparation method of the Flos Trollii extract is similar to Example 3；
The preparation method of the Flos Lonicerae extractive solution is similar to Example 3；
The preparation method of the antiallergy toner containing trollflower is similar to Example 3；
Difference with embodiment 3 is, nano-titanium dioxide is not included in comparative example 4.
A kind of antiallergy toner containing trollflower of comparative example 5
The antiallergy toner containing trollflower, is made of: Flos Trollii extract following component and its weight percent
4%, Flos Lonicerae extractive solution 2%, menthol 0.02%, propylene glycol 0.04%, nano-titanium dioxide 4%, pyrrolidone sodium carboxylate
4%, glycerol 4%, Trenaxmine 1.5%, Sodium Hyaluronate 0.1%, solubilizer 0.15%, chamomile essential oil 0.08%, D- is different to be resisted
Bad hematic acid 0.2%, water 79.91%.
The preparation method of the Flos Trollii extract is similar to Example 3；
The preparation method of the Flos Lonicerae extractive solution is similar to Example 3；
The preparation method of the antiallergy toner containing trollflower is similar to Example 3；
Difference with embodiment 3 is, sweet orange oil is not included in comparative example 5.
1 irritation test of test example
1. test specimen: the antiallergy toner containing trollflower made from embodiment 1-3 and comparative example 1-5
2. subjects: 80 volunteers of the age at 18~30 years old are randomly divided into 8 groups, and every group of 10 people try out examination respectively
Test sample.Subject requires: skin health, without skin medical history, and skin color difference is unobvious.
3. test method: subject is washed one's hands using clear water sooner or later, is smearing test specimen on hand daily, while not smearing it
His skin care item, cosmetics, scope of activities, food of subject etc. do same treatment, after 1 week, observe the specific feelings of subject
Condition.
4. test result: the antiallergy toner containing trollflower made from embodiment 1-3 and comparative example 1-5 is smeared, it is tested
Person does not occur situations such as redness on hand, illustrates all test specimens of this test before without significant change with test product is used
It will not make one to generate allergic reaction.
The test of 2 performance of keeping humidity of test example
1. test specimen: the antiallergy toner containing trollflower made from embodiment 1-3 and comparative example 1-5.
2. subjects: choosing 100 volunteers of 20-45 one full year of life, men and women is fifty-fifty, is randomly divided into 10 groups.
3. test method: daily early morning is washed one's face with clear water, is then smeared made from embodiment 1-3 and comparative example 1-7 respectively
Aloe Vera Gel detects the water content of skin using skin moisture detector after smearing when 1h, 5h, 10h and 15h.
4. test result: specific test result is shown in Table 1.
The moistening effect of 1 different tests sample of table compares
As shown in Table 1, using the antiallergy toner made from 1-3 of the embodiment of the present invention containing trollflower, moistening effect is bright
It is aobvious to stablize, wherein it is most stable with the moistening effect of embodiment 3, it is highly preferred embodiment of the present invention, water content 46-47% is human body
The water content of skin the most comfortable, and the performance of keeping humidity of comparative example is unstable, as time goes by, water content gradually decreases, especially
It is comparative example 2, due to eliminating D-araboascorbic acid, compared with embodiment 1-3, moistening effect is far short of what is expected.
The test of 3 antibacterial anti-inflammatory of test example
1. test specimen: embodiment 1-3 and the antiallergy toner obtained containing trollflower of comparative example -5.
2. subjects: BALB/c mouse 180 of 18-20 week old are chosen, is randomly divided into 9 groups, every group 20, Suo Youshi
Mouse is tested without skin medical history.
3. test method: by every mouse in same side depilation 3cm × 5cm, 12h makees place of stopping eating to mouse before testing
Reason, but do not stop eating, the skin among depilation position is galled with sterile fine sandpaper, with slight oozing of blood for degree of being, forms 2cm × 2cm
Square wound face, in each mouse skin wound site, 1-8 group is smeared respectively made from embodiment 1-3 and comparative example 1-5
Antiallergy toner containing trollflower, the 9th group is used as blank control group, without any processing.
After smearing 12 hours, the wound site of every group of mouse is observed, is counted, wherein abnormal disease does not occur
Shape, namely predetermined substance is not detected in wound site or microorganism is feminine gender, conversely, for the positive.
4. test result: specific test result is shown in Table 2.
The antibacterial anti-inflammatory effect of 2 different tests sample of table
As shown in Table 2, the mouse of the antiallergy toner containing trollflower made from 1-3 of the embodiment of the present invention, 12h are smeared
Afterwards, the inflammatory reaction decline of wound site even disappears, and 90% or more be negative especially contains made from smearing embodiment 3
The mouse of the antiallergy toner of trollflower has good antibacterial anti-inflammatory performance, and after 12h, 95% be negative is therefore, real
Applying example 3 is highly preferred embodiment of the present invention.In comparative example 1-5, Flos Lonicerae extractive solution, antibacterial anti-inflammatory are eliminated in comparative example 1
It can substantially reduce, and in blank group, since mouse itself has certain self-healing ability, so also there is minute quantity immunity strong
Mouse inflammatory reaction disappears.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range, although elaborating referring to preferred embodiment to the present invention, those skilled in the art should be managed
Solution, can with modification or equivalent replacement of the technical solution of the present invention are made, without departing from technical solution of the present invention essence and
Range.
Claims (8)
1. a kind of antiallergy toner containing trollflower, which is characterized in that including following component and its weight percent: trollflower
Extract 2~5%, Flos Lonicerae extractive solution 1~3%, menthol 0.01~0.05%, propylene glycol 0.01~0.05%, nanometer two
Titanium oxide 3%~5%, pyrrolidone sodium carboxylate 2~5%, glycerol 2~5%, Trenaxmine 1%~2%, Sodium Hyaluronate 0.05
~0.15%, solubilizer 0.1~0.2%, chamomile essential oil 0.05~0.1%, D-araboascorbic acid 0.1%~0.3%, sweet orange
Essential oil 0.1%~0.2%, water 73.95~88.58%.
2. the antiallergy toner containing trollflower as described in claim 1, which is characterized in that by following component and its weight percent
Array is at Flos Trollii extract 4%, Flos Lonicerae extractive solution 2%, menthol 0.02%, propylene glycol 0.04%, nano-titanium dioxide
4%, pyrrolidone sodium carboxylate 4%, glycerol 4%, Trenaxmine 1.5%, Sodium Hyaluronate 0.1%, solubilizer 0.15%, chamomile
Essential oil 0.08%, D-araboascorbic acid 0.2%, sweet orange oil 0.15%, water 79.76%.
3. the antiallergy toner containing trollflower as claimed in claim 1 or 2, which is characterized in that the solubilizer is solubilizer
Gelfest CH40。
4. the antiallergy toner containing trollflower as claimed in claim 1 or 2, which is characterized in that the Flos Trollii extract
The preparation method comprises the following steps:
(1) trollflower is taken, impurity is washed away, crushed after being dried crosses 80-100 mesh, obtains trollflower coarse powder；
(2) 8-10 times of weight of trollflower coarse powder of ethyl alcohol is added into trollflower coarse powder obtained by step (1), adds step (1)
The cellulase of gained trollflower coarse powder weight 0.8~1.2%, 2-4h is extracted under conditions of 45-50 DEG C, obtains crude extract；
(3) crude extract obtained by step (2) is warming up to 85-90 DEG C, continues refluxing extraction 3-5h, filtering, and collect filtrate, cools down
To 55-65 DEG C, filtrate is depressurized, be concentrated into relative density be 1.05-1.15 medicinal extract to get.
5. the antiallergy toner containing trollflower as claimed in claim 3, which is characterized in that the preparation of the Flos Trollii extract
Ethyl alcohol in step described in method (2) is the ethanol water that volume fraction is 70-80%.
6. the antiallergy toner containing trollflower as claimed in claim 1 or 2, which is characterized in that the Flos Lonicerae extractive solution
The preparation method comprises the following steps: extracting honeysuckle, crushes after cleaning, drying, the water that 4-8 times of honeysuckle weight is added impregnates 1-2 hours, and reflux mentions
Take 2-3 times, it is 3-4 hours each, filtering, merging filtrate to get.
7. a kind of preparation method of the antiallergy toner as described in claim any one of 1-5 containing trollflower, which is characterized in that
Include the following steps:
S1, by Sodium Hyaluronate, Trenaxmine, nano-titanium dioxide, D-araboascorbic acid and glycerol, be added in agitated kettle, at a slow speed
It stirs evenly, water is added, is heated to 40-50 DEG C, continue to stir 20-30min, until hyaluronic acid is completely dissolved, it is cooling, it is spare；
S2, it takes menthol, chamomile essential oil, sweet orange oil to mix with solubilizer, mixes slowly, propylene glycol, homogeneous 5- is added
15min is then added in the agitated kettle of step S1, stirs and evenly mixs, and obtains mixing liquid；
S3, Flos Trollii extract, Flos Lonicerae extractive solution and pyrrolidone sodium carboxylate is added into mixing liquid obtained by step S2,
Mix slowly it is uniform to system, discharging to get.
8. the preparation method of the antiallergy toner containing trollflower as claimed in claim 6, which is characterized in that the step S1,
That in S2 and S3 is 50-100r/min at a slow speed.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111184667A (en) * | 2020-02-25 | 2020-05-22 | 刘燕 | Composition with moistening and moisture-keeping and anti-allergy effects and preparation method thereof |
| CN111297756A (en) * | 2020-02-25 | 2020-06-19 | 刘燕 | Essence with moistening and moisturizing and anti-allergy effects and preparation method thereof |
| CN113368020A (en) * | 2021-05-11 | 2021-09-10 | 上海游春生物科技有限公司 | All natural cucurbitaceae plant water beauty lotion |
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| CN105534796A (en) * | 2015-12-30 | 2016-05-04 | 广州暨南生物医药研究开发基地有限公司 | Anti-allergic toner containing folium artemisiae argyi extract and preparation method thereof |
| CN109355136A (en) * | 2018-11-05 | 2019-02-19 | 广东大鹏医药科技有限公司 | A kind of preparation method and its handmade soap of lily feet flower essential oil |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105534796A (en) * | 2015-12-30 | 2016-05-04 | 广州暨南生物医药研究开发基地有限公司 | Anti-allergic toner containing folium artemisiae argyi extract and preparation method thereof |
| CN109355136A (en) * | 2018-11-05 | 2019-02-19 | 广东大鹏医药科技有限公司 | A kind of preparation method and its handmade soap of lily feet flower essential oil |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111184667A (en) * | 2020-02-25 | 2020-05-22 | 刘燕 | Composition with moistening and moisture-keeping and anti-allergy effects and preparation method thereof |
| CN111297756A (en) * | 2020-02-25 | 2020-06-19 | 刘燕 | Essence with moistening and moisturizing and anti-allergy effects and preparation method thereof |
| CN113368020A (en) * | 2021-05-11 | 2021-09-10 | 上海游春生物科技有限公司 | All natural cucurbitaceae plant water beauty lotion |
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