CN108653129A - A kind of dressing for skin including the potent antiallergic composition of natural plants - Google Patents
A kind of dressing for skin including the potent antiallergic composition of natural plants Download PDFInfo
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- CN108653129A CN108653129A CN201810612684.9A CN201810612684A CN108653129A CN 108653129 A CN108653129 A CN 108653129A CN 201810612684 A CN201810612684 A CN 201810612684A CN 108653129 A CN108653129 A CN 108653129A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to a kind of dressing for skin including the potent antiallergic composition of natural plants.The dressing ingredient includes 1 10 parts of leek extract, 0.1 5 parts of chrysanthemum extract, 0.1 5 parts of Gotu Kola P.E, 0.1 5 parts of oat extract hydrolyzes 0.05 1 parts of glycosaminoglycan, 0.05 0.5 parts of Sodium Hyaluronate, 0.1 1 parts of carbomer, 0.05 0.5 parts of pH adjusting agent, 0.01 0.5 parts of decoyl hydroximic acid, 72 98 parts of water.Mentioned component combination is fabricated to a kind of dressing of external application, there is the effect of acceleration epidermal cell proliferation, reconstruction skin barrier, quick antiallergic anti-inflammatory, prolonged application not will produce drug resistance, without any side effects, fool proof reliable and cheap.
Description
Technical field
The invention belongs to skin care fields, and in particular to a kind of skin comprising the potent antiallergic composition of natural plants is deposited
Material.
Background technology
Skin covers whole body, various tissues and organ invading from extraneous physics, chemistry and pathogenic microorganism in protective
It attacks.There are two the barrier actions of aspect for skin tool:On the one hand prevent internal water, electrolyte and other substances from losing；Another party
Face prevents the intrusion of extraneous harmful substance.But when sebum film is destroyed, cuticula is directly exposed gradually thinning, and skin can become
Sensitivity, when exposed to heat and cold or other stimulation, skin can show the symptoms such as itch, shouting pain, more seriously when basal layer cell is new
Raw speed is unable to catch up with the impaired speed of cuticula, and the capillary of skin corium will be spread outward to be lost with the nutrition for making up epidermis
Weighing apparatus, there have been so-called red blood silks.Serious skin allergy can also draw skin injury, and the quick of skin is further aggravated in sepage
Perception.
Common rubefaction is itched, " skin allergy " symptom such as hair shaft, although it is difficult to find specific " anaphylactogen ",
But they are " skin barrier is impaired " there are one common ground, that is, skin surface loses normal defencive function and occurs
The loss of moisture of skin, to the drying of skin, furfur or itch occur.Meanwhile the germ of skin surface, pollen, chemicals
The anaphylactogens such as matter are easy to enter inside skin by impaired skin barrier, to further cause scytitis reaction.
The drug for the treatment of skin allergy has often neglected the reparation of skin barrier mostly based on antiallergy at present.Anti- group
Amine cure is the method for conventional therapy skin allergy, the disadvantage is that antihistamine treatment is the work for playing respite allergy
With, and cannot fundamentally solve patient of hypersensitivity's skin volume Geological Problems.Antihistamine drug temporarily solves allergic symptom, but mistake
The basis of quick generation does not change, and under anaphylactogen stimulation, Anaphylactic mediator is still constantly discharging, so antihistamine drug treatment is
It is good for the moment to make, still can recurrent exerbation.And it can inherently allow patient using various hormones, antihistaminic, antibiotic etc
Regulation mechanism burden it is heavier, seriously disturb patient's accurate endocrine systems originally, also cause the normal bacterium of patient's enteron aisle
The imbalance of group, further influences the intestinal absorption function of disease, vitamin, various trace elements normal absorption by serious shadow
It rings.The counter productive of this confrontation sex therapy, is recognized by more and more patients and clinician now.For a long time with
Come, a large amount of Huang amine, steroids drug with only playing the role of alleviating symptom, and side effect is very big, especially right
The development of infant, children and adolescents have significant effect.Allergy patient is the recurrent exerbation month after month throughout the year at each
Middle alleviation symptom, the immunocompetence of body is increasingly low, extremely painful.
The present invention using natural leek as primary raw material, in conjunction with Sodium Hyaluronate be made with repair antiallergic function liquid or
Gel dressing.Some natural plant extracts are added simultaneously, not only can quickly treat skin allergy, and skin screen can be rebuild again
Barrier.Break traditional antiallergy therapy theory, treatment center of gravity is transferred to from antiallergy and is repaired on skin barrier, fundamentally
Cure anaphylaxis skin.The present invention's is pure plant formula, without side-effects, is more suitable for allergic constitution crowd use.
Invention content
The purpose of the present invention is the deficiencies for skin allergy treatment technology, and treatment center of gravity is transferred to reparation from antiallergy
Come on skin barrier, fundamentally cures anaphylaxis skin.To reach this purpose, it includes natural plants that the present invention, which develops a kind of,
The dressing for skin of potent antiallergic composition, the dressing have accelerometer epithelial cell proliferation, rebuild skin barrier, quick antiallergic anti-inflammatory
The effect of, prolonged application not will produce drug resistance, without any side effects, fool proof reliable.
The present invention uses following technical scheme：
A kind of dressing for skin including the potent antiallergic composition of natural plants, includes the component of following parts by weight：Leek carries
Take 1-10 parts of object, 0.1-5 parts of chrysanthemum extract, 0.1-5 parts of Gotu Kola P.E, 0.1-5 parts of oat extract, hydrolysis glucose ammonia
0.05-1 parts of base glycan, 0.05-0.5 parts of Sodium Hyaluronate, 0.1-1 parts of carbomer, 0.05-0.5 parts of pH adjusting agent, decoyl hydroxyl oxime
It is 0.01-0.5 parts sour, 72-98 parts of water.
Preferably, the leek extract is leek rhizome extract.
Preferably, the pH adjusting agent is triethanolamine.
Preferably, the dressing for skin comprising the potent antiallergic composition of natural plants includes the component of following parts by weight：
8 parts of leek extract, 3 parts of chrysanthemum extract, 3 parts of Gotu Kola P.E, 3 parts of oat extract hydrolyze glycosaminoglycan 0.5
Part, 0.25 part of Sodium Hyaluronate, 0.5 part of carbomer, 0.2 part of pH adjusting agent, 0.25 part of decoyl hydroximic acid, 81 parts of water.
The leek extract, especially leek rhizome extract contain volatile oil and sulfide, protein, fat,
Carbohydrate, vitamin B, vitamin C and trace element have extremely strong anti-inflammatory antiallergic effect, and polysaccharide component, which has, repairs skin
The effect of.Anti-inflammatory antiallergic cooperates with restoration and protection so that the effect of leek extract is particularly evident.
The chrysanthemum extract is clearing heat and detoxicating antipruritic, and collaboration improves skin sensitivity and pruritis, is the reparation of skin
Advantage is provided.
The Gotu Kola P.E has effects that immunological regulation, anti-inflammatory, antiulcer.Further, pass through the table that compacts
Skin solves cutis laxa phenomenon with corium coupling part, keeps skin smooth flexible；The formation for promoting dermal collagen, makes fibre
Fibrillarin regenerates, and skin is made to achieve the effect that smooth and promotion wound healing of compacting.
Contain the ingredients such as avenin, oat peptide, oat beta glucan, oat oil in the oat extract.Oat β-
Glucan is one kind linearly without branch's mucopolysaccharide, because it contains a large amount of hydrophilic radical, can absorb moisture or lock skin angle
Matter layer moisture, avenabeta glucosan have extraordinary moisture-keeping efficacy, and fibroblast can be promoted to synthesize collagen, promote
Wound healing has the function of good skin repair.Also contain a large amount of antioxidant in oat extract, has：Caffeic acid,
Ferulic acid, coumaric acid, benzoic acid, vanillic acid, sinapic acid, protocatechuic acid, salicylic acid, gallic acid, syringic acid etc.；Also tie up
Raw element E, avenanthramide etc., these substances can effectively remove free radical, reduce wound of the free radical to Skin Cell
Evil increases skin activity, delaying skin aging, skin whitening, moisturizing, reduction wrinkle color spot, antiallergy and other effects.
The hydrolysis glycosaminoglycan is the cellular water work factor, and activating cell metabolism is conducive to repair cell
Barrier.
Described Sodium Hyaluronate itself is one of composition of human skin, is that a kind of acidity that distribution is most wide in human body is glutinous
Sugar is present in the matrix of connective tissue, has good moisture-keeping function, uses it in cosmetics, can keep skin moisturizing
Smooth, fine and smooth tender, high resilience has the function of wrinkle resistant, crease-resistant, beauty and health care and restores skin physiology function.Further
, the antimicrobial component in Sodium Hyaluronate and leek extract, Gotu Kola P.E and oat extract can ooze rapidly together
Transdermal protects mucosa cells not by invading pathogens, in conjunction with hydrolysis glycosaminoglycan together quick repairing skin tissue,
Wound healing power of regeneration is improved, the antiallergic ability of skin is fundamentally improved.
The carbomer is outstanding gel-type vehicle after neutralizing, and has the important uses such as thickening, suspension, is widely used in breast
In liquid, cream, gel.
The decoyl hydroximic acid is a kind of ideal organic acid, from acidity to neutral whole all holdings unionization state,
It is best antibacterial organic acid.There is highly effective chelating effect, the active element for inhibiting mould to need limits needed for microorganism growth
Environment.The triethanolamine is similar to other aminated compounds, since, there are lone pair electrons, triethanolamine tool is weak on nitrogen-atoms
Alkalinity can generate salt with inorganic acid or organic acid reaction.Triethanolamine can neutralize carbomer, adjust pH.
A kind of preparation method of the dressing for skin comprising the potent antiallergic composition of natural plants, includes the following steps：
(1) Sodium Hyaluronate, carbomer is soluble in water, it is heated to 75-85 degrees Celsius after being uniformly dispersed, maintains half
A hour, then it is cooled to 20-45 degrees Celsius；It adds pH adjusting agent and adjusts pH value between 4.5-7.5, mixture A is made；
(2) leek is cleaned up, grinds the propylene glycol solution stirring immersion 4- for being added that volume parts are 30% at paste
6 hours, preferably 4-5 hour, filtering are removed filter residue, and toward 0.005-0.4 parts of decoyl hydroximic acids of addition in filtrate, are made
Leek extract；
(3) formula ratio leek extract, hydrolysis glycosaminoglycan, chrysanthemum extract, Gotu Kola P.E, oat are weighed
Extract (chrysanthemum extract, Gotu Kola P.E, oat extract are commercially available) is added in the mixture A of step (1), stirs
It mixes uniformly, adds remaining decoyl hydroximic acid, stir evenly, the dressing is made.
Preferably, leek (preferably leek rhizome) and volume parts are 30% propylene glycol solution weight ratio in step (2)
It is 1:1.
Compared with prior art, the beneficial effects of the invention are as follows：Sodium Hyaluronate and leek extract in the dressing, product
Antimicrobial component in the careless extract of snow and oat extract together synergistic combination can rapid skin permeation, protect mucosa cells
Not by invading pathogens, and quick repairing skin tissue, improve skin antiallergic ability；It is extracted comprising various plants in the dressing
Object not only has antibacterial and skin barrier repair function, but also is natural plant formula, without side-effects, is more suitable for allergy body
Matter crowd uses.It in addition, dressing of the present invention is a kind of liquid or gel dressing, can form a film in skin surface, have to skin
There are isolation and protection.Stimulation of the anaphylactogen to skin is reduced, skin resistance is enhanced.Composite formula of the present invention
Main component is leek extract, and source is wide, cheap so that production cost substantially reduces, and is selected for more crowds.
Specific implementation mode
It is intended to further illustrate the present invention with reference to embodiments, is not intended to limit the present invention.
Embodiment 1
A kind of dressing for skin including the potent antiallergic composition of natural plants, includes the component of following parts by weight：Leek carries
Take 1 part of object, 0.1 part of chrysanthemum extract, 0.1 part of Gotu Kola P.E, 0.1 part of oat extract, hydrolysis glycosaminoglycan
0.05 part, 0.05 part of Sodium Hyaluronate, 0.1 part of carbomer, 0.05 part of pH adjusting agent, 0.01 part of decoyl hydroximic acid, 98 parts of water.
A kind of preparation method of the dressing for skin comprising the potent antiallergic composition of natural plants, includes the following steps：
(1) Sodium Hyaluronate, carbomer is soluble in water, it is heated to 75 degrees Celsius after being uniformly dispersed, maintains half
Hour, then it is cooled to 20 degrees Celsius；It adds pH adjusting agent and adjusts pH value to 4.5；
(2) leek is cleaned up, grind be added at paste propylene glycol solution that volume parts are 30% (leek with
30% propylene glycol solution weight ratio is 1:1) stirring is impregnated 4 hours, filtering, removes filter residue, and pungent toward addition 0.005 in filtrate
Leek extract is made in acyl hydroximic acid；
(3) formula ratio leek extract, hydrolysis glycosaminoglycan, chrysanthemum extract, Gotu Kola P.E, oat are weighed
Extract is added in the mixture A of step (1), stirs evenly, add remaining decoyl hydroximic acid, stir evenly, and is made described
Dressing.
Embodiment 2
A kind of dressing for skin including the potent antiallergic composition of natural plants, includes the component of following parts by weight：Radix Folium Allii tuberosi
8 parts of stem extraction, 3 parts of chrysanthemum extract, 3 parts of Gotu Kola P.E, 3 parts of oat extract hydrolyze glycosaminoglycan 0.5
Part, 0.25 part of Sodium Hyaluronate, 0.5 part of carbomer, 0.2 part of pH adjusting agent, 0.25 part of decoyl hydroximic acid, 81 parts of water.
A kind of preparation method of the dressing for skin comprising the potent antiallergic composition of natural plants, includes the following steps：
(1) Sodium Hyaluronate, carbomer is soluble in water, it is heated to 80 degrees Celsius after being uniformly dispersed, maintains half
Hour, then it is cooled to 35 degrees Celsius；It adds pH adjusting agent and adjusts pH value to 5.5, mixture A is made；
(2) leek rhizome is removed into fibrous root, cleaned up, ground into paste, the propylene glycol that volume parts are 30% is added
(leek rhizome and 30% propylene glycol solution weight ratio are 1 to solution:1) stirring is impregnated 5 hours, filtering, removes filter residue, and past filter
0.1 part of decoyl hydroximic acid is added in liquid, and leek rhizome extract is made；
(3) weigh formula ratio leek rhizome extract, hydrolysis glycosaminoglycan, chrysanthemum extract, Gotu Kola P.E,
Oat extract is added in the mixture A of step (1), stirs evenly, add remaining decoyl hydroximic acid, stir evenly, and is made
The dressing.
Embodiment 3
A kind of dressing for skin including the potent antiallergic composition of natural plants, includes the component of following parts by weight：Leek carries
10 parts of object is taken, 5 parts of chrysanthemum extract, 5 parts of Gotu Kola P.E, 5 parts of oat extract hydrolyzes 1 part of glycosaminoglycan, transparent
0.5 part of matter acid sodium, 1 part of carbomer, 0.5 part of pH adjusting agent, 0.5 part of decoyl hydroximic acid, 72 parts of water.
A kind of preparation method of the dressing for skin comprising the potent antiallergic composition of natural plants, under including the following steps：
(1) Sodium Hyaluronate, carbomer is soluble in water, it is heated to 85 degrees Celsius after being uniformly dispersed, maintains half
Hour, then it is cooled to 45 degrees Celsius；It adds pH adjusting agent and adjusts pH value to 7.5；
(2) leek is cleaned up, grind be added at paste propylene glycol solution that volume parts are 30% (leek with
30% propylene glycol solution weight ratio is 1:1) stirring is impregnated 6 hours, filtering, removes filter residue, and pungent toward 0.4 part of addition in filtrate
Leek extract is made in acyl hydroximic acid；
(3) formula ratio leek extract, hydrolysis glycosaminoglycan, chrysanthemum extract, Gotu Kola P.E, oat are weighed
Extract is added in the mixture A of step (1), stirs evenly, add remaining decoyl hydroximic acid, stir evenly, and is made described
Dressing.
Properties of product are tested
One, product antiallergic measure of merit
1. subjects：200 skin allergy volunteers, each 100 of men and women, age distribution 3-60 Sui is randomly divided into four
Group.
2. therapy：Four groups of experiments, A groups are divided to apply dressing prepared by embodiment 2, B groups apply the deposited of the preparation of embodiment 2
Material (but being free of leek extract), blank group, D groups apply drug of certain well-known treatment skin allergy on the market to C groups as a contrast.
It is each primary daily morning and evening, skin allergy area is washed down before coating.First time further consultation after continuous use 1 day, second after being used continuously 3 days
Secondary further consultation continues using third time further consultation after 5 days.
3. criterion：
(1) effective：The allergic phenomenas such as red swelling of the skin, itch, damage disappear.
(2) effectively：The allergic phenomenas such as red swelling of the skin, itch, damage mitigate.
(3) invalid：The allergic phenomenas such as red swelling of the skin, itch, damage are without significant change.
(4) it aggravates：The allergic phenomenas such as red swelling of the skin, itch, damage aggravate.
4. treatment results are listed in table 1.
Table 1：Treatment results
Table 1 shows：A groups just have 48 people to have remarkable result after 1 day, and B groups do not have, A groups and B group test result tables
Bright, when product of the present invention includes leek extract, product has very strong antiallergic effect.A groups and D groups the result shows that, this
It is faster and better to invent the product antiallergic effect.C is blank control group, more serious due to not treating within 3 days allergic phenomena, in order to by
The health of tester does not just remake blank control after 3 days.
Claims (8)
1. a kind of dressing for skin including the potent antiallergic composition of natural plants, which is characterized in that include the group of following parts by weight
Point：1-10 parts of leek extract, 0.1-5 parts of chrysanthemum extract, 0.1-5 parts of Gotu Kola P.E, 0.1-5 parts of oat extract,
Hydrolyze 0.05-1 parts of glycosaminoglycan, 0.05-0.5 parts of Sodium Hyaluronate, 0.1-1 parts of carbomer, pH adjusting agent 0.05-0.5
Part, 0.01-0.5 parts of decoyl hydroximic acid, 72-98 parts of water.
2. the dressing for skin according to claim 1 for including the potent antiallergic composition of natural plants, which is characterized in that described
Leek extract is leek rhizome extract.
3. the dressing for skin according to claim 1 for including the potent antiallergic composition of natural plants, which is characterized in that described
PH adjusting agent is triethanolamine.
4. the dressing for skin according to any one of claim 1-3 for including the potent antiallergic composition of natural plants, special
Sign is, includes the component of following parts by weight：8 parts of leek extract, 3 parts of chrysanthemum extract, 3 parts of Gotu Kola P.E, oat
3 parts of extract, 0.5 part of glycosaminoglycan of hydrolysis, 0.25 part of Sodium Hyaluronate, 0.5 part of carbomer, 0.2 part of pH adjusting agent are pungent
0.25 part of acyl hydroximic acid, 81 parts of water.
5. the dressing for skin according to any one of claim 1-3 for including the potent antiallergic composition of natural plants, special
Sign is that the physical aspect of the dressing is liquid or gel.
6. a kind of dressing for skin comprising the potent antiallergic composition of natural plants according to any one of claim 1-4
Preparation method, which is characterized in that include the following steps：
(1) Sodium Hyaluronate, carbomer is soluble in water, it is heated to 75-85 degrees Celsius after being uniformly dispersed, maintains half small
When, it is then cooled to 20-45 degrees Celsius, pH adjusting agent is added and adjusts pH value between 4.5-7.5, mixture A is made；
(2) leek is cleaned up, grinds propylene glycol solution stirring immersion 4-6 for being added that volume parts are 30% at paste
Hour, filtering removes filter residue, and toward 0.005-0.4 parts of decoyl hydroximic acids of addition in filtrate, leek extract is made；
(3) formula ratio leek extract, hydrolysis glycosaminoglycan, chrysanthemum extract, Gotu Kola P.E, oat extraction are weighed
Object is added in the mixture A of step (1), stirs evenly；Remaining decoyl hydroximic acid is added, is stirred evenly, is made described and applies
Material.
7. the preparation method of the dressing for skin according to claim 6 comprising the potent antiallergic composition of natural plants, special
Sign is that the propylene glycol solution that leek is 30% with volume parts in step (2) is 1 according to weight ratio:1 ratio stirring leaching
Bubble.
8. a kind of dressing for skin comprising the potent antiallergic composition of natural plants according to any one of claim 1-4 is answered
For skin antiallergic or skin care.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109498550A (en) * | 2018-12-19 | 2019-03-22 | 曲沃李时珍医药科技有限公司 | A kind of medical facial cold compress gel and preparation method thereof improving sensitive problem |
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| CN111297713A (en) * | 2020-04-15 | 2020-06-19 | 斑敏痘(广东)皮肤研究院 | Anti-allergy repair skin care preparation |
| CN111803703A (en) * | 2020-06-29 | 2020-10-23 | 华仁药业股份有限公司 | Gel dressing containing icodextrin |
| CN111803703B (en) * | 2020-06-29 | 2022-04-12 | 华仁药业股份有限公司 | Gel dressing containing icodextrin |
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