CN109498550A - A kind of medical facial cold compress gel and preparation method thereof improving sensitive problem - Google Patents

A kind of medical facial cold compress gel and preparation method thereof improving sensitive problem Download PDF

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Publication number
CN109498550A
CN109498550A CN201811566339.2A CN201811566339A CN109498550A CN 109498550 A CN109498550 A CN 109498550A CN 201811566339 A CN201811566339 A CN 201811566339A CN 109498550 A CN109498550 A CN 109498550A
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parts
extract
cold compress
compress gel
sensitive problem
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刘小俊
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Quwo Li Shizhen Pharmaceutical Technology Co Ltd
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Quwo Li Shizhen Pharmaceutical Technology Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a kind of medical facial cold compress gels for improving sensitive problem, including activity extract, Sodium Hyaluronate, carbomer and hydrogel；The activity extract is the extract of Radix Salviae Miltiorrhizae, Caulis Spatholobi, rhizoma corydalis, rhizome of chuanxiong, Radix Rehmanniae, cynomorium songaricum, balsam pear, imperial tongue, aloe, cassia seed, rosin, cicada slough, Golden Larch Bark and folium eucalypti；The activity extract, Sodium Hyaluronate, carbomer and hydrogel weight ratio be 10:1~10:1~10:10~50.The invention also discloses the preparation methods for the medical facial cold compress gel for improving sensitive problem.The medical facial cold compress gel that the present invention improves sensitive problem is capable of the itch that effectively therapeutic sensitivity skin occurs, shouting pain, scorching hot, tight and red and swollen etc. symptoms, and treated effect is high, reaches the level of existing common medicine Compound Dexamethasone Acetate.

Description

A kind of medical facial cold compress gel and preparation method thereof improving sensitive problem
Technical field
The present invention relates to Traditional-Chinese-medicine-type technical field of skin care more particularly to a kind of medical faces for improving sensitive problem Portion's cold compress gel, the invention further relates to a kind of preparation methods of medical facial cold compress gel for improving sensitive problem.
Background technique
Sensitive is a kind of special skin type, refers to that skin when by environmental stimuli, erythema, mound easily occurs The nbjective symptoms such as rash, telangiectasis are accompanied by the subjective symptoms such as itch, shouting pain, scorching hot, tight feeling.According to incompletely statistics It was found that there are about 1/3 or more people to suffer from allergic disorders in life both at home and abroad, each area female sensitive skin person is accounted for just 50% or more ordinary person group.Due to sensitive diverse clinical manifestations and subjectivity is strong, and influence factor is complicated, never clear Definition and diagnosis.Current diagnosis method mainly has subjective assessment and objective evaluation.1. subjective assessment is usually in the form of questionnaire It carries out, is the self rating of sensitive subjects, including patient in the itch, shouting pain, scorching hot, tight generated after by the stimulation of various chemical factors The subjective sensations such as taut sense；2. half subjective testing mainly has lactic acid prick test, capsaicine test, acetamide test etc.；3. objective Evaluation is evaluated according to the testing result of various test apparatuses.Such as moisture of skin tester, Neurometer CPT inspection Survey instrument, skin chromaticity detector etc..With cosmetics be widely used and the continuous deterioration of environment, sensitive skin, which has become, to be faced Common skin problem on bed, causes to seriously affect to the quality of life of patient, therefore it has become the concern of dermatology field One of hot spot.
Currently, the method for clinical treatment sensitive skin type problem mainly includes western medical treatment and tcm syndrome differentiation and treatment.West Curing and treating drug used includes antihistamine drug, the drug of Chinese medicine cool blood, antibiotic, corticosteroid hormone etc..Chinese medical discrimination The prescription for the treatment of emphasizes blood-nourishing dispelling wind, blood-nourishing skin-moisturizing etc. mostly.But below the existing presence for improving sensitive problem Defect: (1) existing doctor trained in Western medicine class drug is usually palliative, can short-term relief symptom, but high recurrence rate is easy to form Drug dependence.(2) drug of existing Chinese medicine is usually because effective ingredient concentration is low, when improving cutaneous sensibility symptom Between it is long, effect is poor, middle or short term medication is difficult to realize the effect of remission.(3) existing Chinese medicinal formulae needs patient certainly mostly Row is fried, oral, uses inconvenience, and usually bring sense of discomfort using the process of Chinese medicinal formulae, is repelled by patient.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of improvement sensitive problems Medical facial cold compress gel, with the Western medicine that solves the problems, such as to be currently used for improvement sensitive, there are palliative recurrence rates It is high, it is easy to form drug dependence the problems such as, also can effectively avoid effective component concentration existing for Chinese medicine it is low, improve skin sensitivity Property the problems such as symptom time is long, effect is poor, middle or short term medication is difficult to realize remission.
The second object of the present invention is to provide a kind of system of medical facial cold compress gel for improving sensitive problem Preparation Method, the medical facial cold compress gel of the improvement sensitive problem prepared by this method, which can overcome, to be currently used for changing The Western medicine of kind sensitive problem the problems such as there are palliative high recurrence rates, drug dependence easy to form, can also have Effect avoids the defects of effective component concentration existing for corresponding Chinese medicine is low, the improvement cutaneous sensibility symptom time is long, effect is poor.
An object of the present invention adopts the following technical scheme that realization:
A kind of medical facial cold compress gel improving sensitive problem, including activity extract, Sodium Hyaluronate, card Wave nurse and hydrogel；
The activity extract is Radix Salviae Miltiorrhizae, Caulis Spatholobi, rhizoma corydalis, rhizome of chuanxiong, Radix Rehmanniae, cynomorium songaricum, balsam pear, imperial tongue, aloe, Cassia Son, rosin, cicada slough, Golden Larch Bark and folium eucalypti extract；
The activity extract, Sodium Hyaluronate, carbomer and hydrogel weight ratio be 10:1~10:1~10:10~ 50。
Further, by weight, the Radix Salviae Miltiorrhizae is 3~15 parts, and the Caulis Spatholobi is 2~10 parts, the rhizoma corydalis Be 6~20 parts, the rhizome of chuanxiong be 4~16 parts, the Radix Rehmanniae be 1~10 part, the cynomorium songaricum be 2~8 parts, the balsam pear be 3~ 12 parts, the dragon tongue is 5~12 parts, and the aloe is 3~10 parts, and the cassia seed is 5~20 parts, and the rosin is 3~15 Part, the cicada slough is 4~18 parts, and the Golden Larch Bark is 6~24 parts, and the folium eucalypti is 6~15 parts.
Further, by weight, the Radix Salviae Miltiorrhizae is 5~10 parts, and the Caulis Spatholobi is 4~8 parts, and the rhizoma corydalis is 10~15 parts, the rhizome of chuanxiong is 8~12 parts, and the Radix Rehmanniae is 3~7 parts, and the cynomorium songaricum is 4~6 parts, and the balsam pear is 5~9 Part, the dragon tongue is 7~10 parts, and the aloe is 5~9 parts, and the cassia seed is 8~16 parts, and the rosin is 6~12 parts, The cicada slough is 9~15 parts, and the Golden Larch Bark is 12~20 parts, and the folium eucalypti is 9~12 parts.
Further, by weight, the Radix Salviae Miltiorrhizae is 7 parts, and the Caulis Spatholobi is 6 parts, and the rhizoma corydalis is 13 parts, institute Stating rhizome of chuanxiong is 9 parts, and the Radix Rehmanniae is 5 parts, and the cynomorium songaricum is 5 parts, and the balsam pear is 7 parts, and the dragon tongue is 9 parts, the aloe It is 7 parts, the cassia seed is 12 parts, and the rosin is 9 parts, and the cicada slough is 12 parts, and the Golden Larch Bark is 16 parts, the folium eucalypti It is 11 parts.
The second object of the present invention adopts the following technical scheme that realization:
The preparation method of the medical facial cold compress gel described in any of the above embodiments for improving sensitive problem, including with Lower step:
Stock: weighing Radix Salviae Miltiorrhizae, Caulis Spatholobi, rhizoma corydalis, rhizome of chuanxiong, Radix Rehmanniae and cynomorium songaricum constituent component A, weighs balsam pear, imperial tongue, reed Luxuriant growth and cassia seed constituent component B weigh rosin, cicada slough, Golden Larch Bark and folium eucalypti constituent component C, component A, B and C are pulverized, Cross 10~40 meshes；
It prepares the first extract: 75~95% ethyl alcohol is added with the solid-liquid ratios of 1:5~15 in component A, stirring, impregnate 20~ After 80min, concentrate is concentrated under reduced pressure into 0.5~2.5h of refluxing extraction at 70~85 DEG C, filtering, filtrate, adds anhydrous second Alcohol standing, Precipitation take supernatant heating to be concentrated into paste, the first extract are made；
It prepares the second extract: 75~95% ethyl alcohol is added with the solid-liquid ratios of 1:4~10 in component B, stirring, impregnate 20~ After 60min, 1~5h of refluxing extraction at 60~70 DEG C, filtering, filtrate are concentrated under reduced pressure to give concentrate, concentrate with 0.5~ 5% dissolving with hydrochloric acid takes lysate part to be adjusted to pH8.6~10.4 with ammonium hydroxide, continuously adds the two of 2~5 times of lysate volume Dichloromethane layer is concentrated under reduced pressure into powdered, obtained second extract for chloromethanes, mixing, layering；
Prepare third extract: by component C with the solid-liquid ratios of 1:2~5 be added 0.5~2mol/L acetum and with Dehydrated alcohol is added in the solid-liquid ratio of 1:5~15, and 100~500W ultrasonic extraction time is 10~60min, 3000~8000r/min Be centrifuged 3~15min, clear liquid is condensed into medicinal extract shape after centrifugation, by the chloroform refluxing extraction 20 of 2~5 times of volumes of medicinal extract~ Third extract is made in being concentrated into paste on water-bath in 90min, extracting solution；
Preparations shaping: by the first extract, the second extract, third extract, Sodium Hyaluronate, carbomer and hydrogel It is uniformly mixed, is modulated into emulsifiable paste shape with glycerol, the medical facial cold compress gel for improving sensitive problem is made.
Further, in preparing the first extract step, 80% ethyl alcohol is added with the solid-liquid ratio of 1:10 in component A, is stirred After mixing, impregnating 50min, refluxing extraction 1.5h at 78 DEG C, double gauze filtering, filtrate are transferred in vacuum rotary evaporator and depressurize It is condensed into concentrate, thickening temperature is 68 DEG C, and vacuum degree is -0.04MPa；
The dehydrated alcohol that 3 times of volumes of concentrate are added stands, is layered, and takes supernatant to be placed on 70 DEG C of thermostat water baths and is concentrated To paste, the first extract is made.
Further, in preparing the second extract step, 85% ethyl alcohol is added with the solid-liquid ratio of 1:8 in component B, is stirred After mixing, impregnating 30min, refluxing extraction 2.5h at 65 DEG C, filtering, filtrate are transferred in vacuum rotary evaporator and are concentrated under reduced pressure to give Concentrate, wherein thickening temperature is 55 DEG C, and vacuum degree is -0.08MPa.
Further, 1.5% dissolving with hydrochloric acid of concentrate, separates lysate part, takes lysate part ammonium hydroxide tune To pH9.4,4 times of lysate volume of methylene chloride is continuously added, dichloromethane layer is concentrated under reduced pressure into powder for mixing, layering The second extract is made in shape；
Wherein, it is 37 DEG C that temperature, which is concentrated under reduced pressure, and vacuum degree is -0.02MPa.
Further, in preparation third extract step, component C is added to the acetic acid of 1mol/L with the solid-liquid ratio of 1:3 Solution and dehydrated alcohol is added with the solid-liquid ratio of 1:10,300W ultrasonic extraction 35min, 6000r/min is centrifuged 8min, after centrifugation Clear liquid, which is transferred in vacuum rotary evaporator, is condensed into medicinal extract shape, wherein thickening temperature is 60 DEG C, and vacuum degree is -0.15MPa；
By the medicinal extract chloroform refluxing extraction 60min of 3.5 times of volumes, extracting solution is thick in being concentrated on 45 DEG C of thermostat water baths Paste.
Further, in preparations shaping step, the first extract, the second extract, third extract are mixed in advance Primary extract is made, adds Sodium Hyaluronate, carbomer and hydrogel, is uniformly mixed；
Wherein, the weight ratio of primary extract, Sodium Hyaluronate, carbomer and hydrogel is 10:3:3:20.
Compared with prior art, the beneficial effects of the present invention are:
(1) present invention improve sensitive problem medical facial cold compress gel can effectively therapeutic sensitivity skin go out Existing itch, shouting pain, scorching hot, tight and red and swollen etc. symptoms, treated effect is high, reaches the level of existing common medicine Compound Dexamethasone Acetate. Identical as existing common medicine Compound Dexamethasone Acetate in the scales of skin that peel off symptom occurred for sensitive, the present invention improves sensitive The improvement of the medical facial cold compress gel of problem is general.Compared with existing common medicine Compound Dexamethasone Acetate, the present invention improves sensitive Property skin problem the medical facial cold compress gel more excellent effect that also has recurrence rate low.In addition, the present invention improves sensibility skin The medical facial cold compress gel of skin problem using Chinese medical extract as effective component, in therapeutic process without toxic, side effects, by In the endothermic effect of cold compress gel, moreover it is possible to the burning heat sensation of skin surface is siphoned away rapidly, brings refrigerant comfort for patient, it is effectively slow Solve the red and swollen heat pain sense that inflammation causes.
(2) present invention improves the preparation method of the medical facial cold compress gel of sensitive problem, passes through party's legal system The medical facial cold compress gel of standby improvement sensitive problem can be effectively retained the effective component of various activity extracts, Including acid-soluble ingredient (i.e. alkaloid), liposoluble constituent and the other active constituents in Chinese herbal medicine, by means of a variety of extractions Mode is conducive to sufficiently discharge the active constituent in Chinese medicine, by means of a variety of purification process, further promotes the dense of active constituent Degree finally combines the complex role of each effective component, can effectively penetrate skin disease and act on subcutaneous tissue, guarantees quickly slow The various symptoms that sensitive causes are solved, drug component function and effect is promoted, shortens action time, long-time service does not cause pair Effect, facilitates patient to use.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
Hereinafter, by Examples 1 to 5, the present invention will be described in detail improves the medical facial cold compress gel of sensitive problem Preparation process.
Embodiment 1
Material preparation step: weighing the Radix Salviae Miltiorrhizae dried is 3g, Caulis Spatholobi 10g, rhizoma corydalis 20g, rhizome of chuanxiong 4g, Radix Rehmanniae 1g and cynomorium songaricum 2g constituent component A.Weigh the balsam pear 12g dried, imperial tongue 5g, aloe 10g and cassia seed 5g constituent component B.It weighs and dries Rosin 15g, cicada slough 4g, Golden Larch Bark 24g and folium eucalypti 6g constituent component C.
It prepares the first extract step: component A is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:5, the ethyl alcohol that mass fraction is 95% is added into round-bottomed flask, and stirring rod is set and stirs 80min in a round bottom flask (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into condensing reflux pipeline and is prepared into one Set reflux extraction element, round-bottomed flask is placed in 85 DEG C of thermostat water baths, and rotation round-bottomed flask carries out refluxing extraction 0.5h.It returns After flowing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, filtrate is transferred to vacuum In Rotary Evaporators, there is wall built-up and (opens in rotary evaporation to extracting solution under the conditions of vacuum degree is -0.01MPa and temperature is 75 DEG C Begin to occur sticky) phenomenon when stop, then dehydrated alcohol is added into round-bottomed flask, the addition volume of dehydrated alcohol is concentrated liquid Long-pending 3 times vibrate round-bottomed flask and concentrate are uniformly mixed with dehydrated alcohol, stand for 24 hours, be layered, dehydrated alcohol The contamination precipitations such as protein, polysaccharide, inorganic salts are precipitated, the effective component being achieved in purified components A.Aspirate supernatant is simultaneously It is transferred on 65 DEG C of thermostat water baths, heating, stirring are concentrated into and become paste, and the first extract is made as a result,.
It prepares the second extract step: component B is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:5, the ethyl alcohol that mass fraction is 95% is added into round-bottomed flask, and stirring rod is set and stirs 60min in a round bottom flask (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into condensing reflux pipeline and is prepared into one Set reflux extraction element, round-bottomed flask is placed in the thermostat water bath that temperature is 70 DEG C, and rotation round-bottomed flask carries out reflux and mentions Take 1h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, filtrate is shifted Into vacuum rotary evaporator, rotary evaporation to extracting solution is hung under the conditions of vacuum degree is -0.02MPa and temperature is 60 DEG C Wall (starts to occur sticky) to stop when phenomenon, and concentrate is made.5% hydrochloric acid solution, concentration are added into concentrate obtained The ratio between volume of liquid and hydrochloric acid solution is 1:1, and the stirring of Bian Tianjia hydrochloric acid solution side stands 1h, obtains acid dissolution part and non-acid Part is dissolved, taking acid dissolution part pH value is 10.6 ammonium hydroxide tune pH8.6, continuously adds methylene chloride, wherein acid dissolution portion Dividing with the volume ratio of methylene chloride is 1:2, oscillation mixing, stratification.It draws dichloromethane layer and is transferred to vacuum rotating steaming Hair instrument, setting evaporating temperature are 33 DEG C, and vacuum degree is -0.08MPa, are evaporated under reduced pressure into powdered, obtained second extract.
Preparation third extract step: component C is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) be 1:5 amount add the acetum of 0.5mol/L into round-bottomed flask, according still further to solid-liquid ratio (i.e. the ratio between quality volume be worth) Dehydrated alcohol is added for the amount of 1:5, oscillation mixes.Round-bottomed flask is transferred in Ultrasound Instrument, adjusting ultrasonic power is 500W, is surpassed Sound extracts 10min.After ultrasonic extraction process, extracting solution is filtered by double gauze, the dregs of a decoction is filtered out, collects filtrate.It will Filtrate is transferred in centrifuge tube, and centrifuge tube, which is placed in a centrifuge, to be centrifuged, centrifuge RPMs 3000r/min, and centrifugation time is 15min.Centrifuge tube is taken out after centrifugation, absorption supernatant liquor, which is transferred in vacuum rotary evaporator, is condensed into medicinal extract shape, In, thickening temperature is 60 DEG C, and vacuum degree is -0.15MPa.The chloroform for adding 2 times of supernatant liquor volumes into concentrate bottle again, will be dense Contracting bottle is placed in the thermostat water bath that temperature is 45 DEG C, and spin concentration bottle carries out refluxing extraction 20min.After refluxing extraction, Extracting solution is transferred in triangular flask and triangular flask is placed on the thermostat water bath that temperature is 45 DEG C, in heating evaporation chloroform Third extract is made until chloroform evaporated is complete and is concentrated into paste (or blocky) in stirring.
Preparations shaping step: the first extract, the second extract and third extract are stirred and evenly mixed in advance, primary is made Medicinal extract, then primary extract, Sodium Hyaluronate, carbomer and hydrogel are uniformly mixed, it is modulated into emulsifiable paste shape with glycerol, is obtained The present invention improves the medical facial cold compress gel of sensitive problem.Wherein, primary extract, Sodium Hyaluronate, carbomer and The weight ratio of hydrogel is 10:1:1:50.
Embodiment 2
Material preparation step: weighing the Radix Salviae Miltiorrhizae dried is 10g, Caulis Spatholobi 8g, rhizoma corydalis 10g, rhizome of chuanxiong 12g, Radix Rehmanniae 3g and lock Positive 6g constituent component A.Weigh the balsam pear 9g dried, imperial tongue 10g, aloe 5g and cassia seed 16g constituent component B.It weighs and dries Rosin 6g, cicada slough 9g, Golden Larch Bark 12g and folium eucalypti 12g constituent component C.
It prepares the first extract step: component A is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:8, the ethyl alcohol that mass fraction is 90% is added into round-bottomed flask, and stirring rod is set and stirs 65min in a round bottom flask (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into condensing reflux pipeline and is prepared into one Set reflux extraction element, round-bottomed flask is placed in 82 DEG C of thermostat water baths, and rotation round-bottomed flask carries out refluxing extraction 1h.Reflux After extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, filtrate is transferred to vacuum rotation Turn in evaporimeter, wall built-up (beginning occurs in rotary evaporation to extracting solution under the conditions of vacuum degree is -0.02MPa and temperature is 72 DEG C Occur sticky) phenomenon when stop, then dehydrated alcohol is added into round-bottomed flask, the addition volume of dehydrated alcohol is the volume of the concentrated liquid 4 times, oscillation round-bottomed flask simultaneously concentrate is uniformly mixed with dehydrated alcohol, standing for 24 hours, be layered, dehydrated alcohol makes The contamination precipitations such as protein, polysaccharide, inorganic salts are precipitated, the effective component being achieved in purified components A.Aspirate supernatant simultaneously turns It moves on 68 DEG C of thermostat water baths, heating, stirring are concentrated into and become paste, and the first extract is made as a result,.
It prepares the second extract step: component B is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:10, the ethyl alcohol that mass fraction is 80% is added into round-bottomed flask, and stirring rod is set and is stirred in a round bottom flask 45min (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into the pipeline system of condensing reflux Standby to be placed in round-bottomed flask in the thermostat water bath that temperature is 68 DEG C at a set of refluxing extraction device, rotation round-bottomed flask carries out Refluxing extraction 1.5h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, it will Filtrate is transferred in vacuum rotary evaporator, and rotary evaporation extremely extracts under the conditions of vacuum degree is -0.05MPa and temperature is 58 DEG C There is wall built-up and (starts to occur sticky) to stop when phenomenon in liquid, and concentrate is made.Into concentrate obtained, the hydrochloric acid of addition 4% is molten The ratio between volume of liquid, concentrate and hydrochloric acid solution is 1:2, and the stirring of Bian Tianjia hydrochloric acid solution side stands 1h, obtains acid dissolution part With non-acid dissolution part, taking acid dissolution part pH value is 11.2 ammonium hydroxide tune pH9.0, continuously adds methylene chloride, wherein acid The volume ratio of dissolution part and methylene chloride is 1:3, oscillation mixing, stratification.It draws dichloromethane layer and is transferred to vacuum Rotary Evaporators, it is 35 DEG C that evaporating temperature, which is arranged, and vacuum degree is -0.05MPa, is evaporated under reduced pressure into powdered, obtained second extraction Object.
Preparation third extract step: component C is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) be 1:4 amount add 0.75mol/L acetum into round-bottomed flask, according still further to solid-liquid ratio (i.e. the ratio between quality volume It is worth) dehydrated alcohol is added for the amount of 1:8, oscillation mixes.Round-bottomed flask is transferred in Ultrasound Instrument, adjusting ultrasonic power is 400W, ultrasonic extraction 25min.After ultrasonic extraction process, extracting solution is filtered by double gauze, the dregs of a decoction is filtered out, collects Filtrate.Filtrate is transferred in centrifuge tube, centrifuge tube, which is placed in a centrifuge, to be centrifuged, centrifuge RPMs 4500r/min, centrifugation Time is 10min.Centrifuge tube is taken out after centrifugation, absorption supernatant liquor, which is transferred in vacuum rotary evaporator, is condensed into medicinal extract Shape, wherein thickening temperature is 70 DEG C, and vacuum degree is -0.15MPa.The chlorine of 3 times of supernatant liquor volumes is added into concentrate bottle again It is imitative, concentrate bottle is placed in the thermostat water bath that temperature is 50 DEG C, spin concentration bottle carries out refluxing extraction 35min.Refluxing extraction After, extracting solution is transferred in triangular flask and triangular flask is placed on the thermostat water bath that temperature is 55 DEG C, side heating is steamed The stirring of chloroform side is sent out, until chloroform evaporated is complete and is concentrated into paste (or blocky), third extract is made.
Preparations shaping step: the first extract, the second extract and third extract are stirred and evenly mixed in advance, primary is made Medicinal extract, then primary extract, Sodium Hyaluronate, carbomer and hydrogel are uniformly mixed, it is modulated into emulsifiable paste shape with glycerol, is obtained The present invention improves the medical facial cold compress gel of sensitive problem.Wherein, primary extract, Sodium Hyaluronate, carbomer and The weight ratio of hydrogel is 10:5:5:30.
Embodiment 3
Material preparation step: weighing the Radix Salviae Miltiorrhizae dried is 7g, Caulis Spatholobi 6g, rhizoma corydalis 13g, rhizome of chuanxiong 9g, Radix Rehmanniae 5g and cynomorium songaricum 5g constituent component A.Weigh the balsam pear 7g dried, imperial tongue 9g, aloe 7g and cassia seed 12g constituent component B.Weigh the pine dried Fragrant 9g, cicada slough 12g, Golden Larch Bark 16g and folium eucalypti 11g constituent component C.
It prepares the first extract step: component A is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:10, the ethyl alcohol that mass fraction is 80% is added into round-bottomed flask, and stirring rod is set and is stirred in a round bottom flask 50min (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into the pipeline system of condensing reflux Standby that round-bottomed flask is placed in 78 DEG C of thermostat water baths at a set of refluxing extraction device, rotation round-bottomed flask carries out refluxing extraction 1.5h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, filtrate is shifted Into vacuum rotary evaporator, rotary evaporation to extracting solution is hung under the conditions of vacuum degree is -0.04MPa and temperature is 68 DEG C Wall (starts to occur sticky) to stop when phenomenon, then dehydrated alcohol is added into round-bottomed flask, and the addition volume of dehydrated alcohol is dense 5 times of contracting liquid product vibrate round-bottomed flask and concentrate are uniformly mixed with dehydrated alcohol, stand for 24 hours, be layered, nothing The contamination precipitations such as protein, polysaccharide, inorganic salts are precipitated in water-ethanol, the effective component being achieved in purified components A.In absorption Clear liquid is simultaneously transferred on 70 DEG C of thermostat water baths, and heating, stirring are concentrated into and become paste, and the first extract is made as a result,.
It prepares the second extract step: component B is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:8, the ethyl alcohol that mass fraction is 85% is added into round-bottomed flask, and stirring rod is set and stirs 30min in a round bottom flask (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into condensing reflux pipeline and is prepared into one Set reflux extraction element, round-bottomed flask is placed in the thermostat water bath that temperature is 65 DEG C, and rotation round-bottomed flask carries out reflux and mentions Take 2.5h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, filtrate is turned It moves in vacuum rotary evaporator, rotary evaporation to extracting solution occurs under the conditions of vacuum degree is -0.08MPa and temperature is 55 DEG C Wall built-up (starts to occur sticky) to stop when phenomenon, and concentrate is made.2.5% hydrochloric acid solution is added into concentrate obtained, The ratio between volume of concentrate and hydrochloric acid solution is 1:2.5, and the stirring of Bian Tianjia hydrochloric acid solution side stands 1h, obtains acid dissolution part With non-acid dissolution part, taking acid dissolution part pH value is 11.2 ammonium hydroxide tune pH9.4, continuously adds methylene chloride, wherein acid The volume ratio of dissolution part and methylene chloride is 1:4, oscillation mixing, stratification.It draws dichloromethane layer and is transferred to vacuum Rotary Evaporators, it is 37 DEG C that evaporating temperature, which is arranged, and vacuum degree is -0.02MPa, is evaporated under reduced pressure into powdered, obtained second extraction Object.
Preparation third extract step: component C is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) be 1:3 amount add 1mol/L acetum into round-bottomed flask, be according still further to solid-liquid ratio (i.e. the ratio between quality volume value) The amount of 1:10 adds dehydrated alcohol, and oscillation mixes.Round-bottomed flask is transferred in Ultrasound Instrument, adjusting ultrasonic power is 300W, is surpassed Sound extracts 35min.After ultrasonic extraction process, extracting solution is filtered by double gauze, the dregs of a decoction is filtered out, collects filtrate.It will Filtrate is transferred in centrifuge tube, and centrifuge tube, which is placed in a centrifuge, to be centrifuged, centrifuge RPMs 6000r/min, and centrifugation time is 8min.Centrifuge tube is taken out after centrifugation, absorption supernatant liquor, which is transferred in vacuum rotary evaporator, is condensed into medicinal extract shape, In, thickening temperature is 60 DEG C, and vacuum degree is -0.15MPa.The chloroform of 3.5 times of supernatant liquor volumes is added into concentrate bottle again, it will Concentrate bottle is placed in the thermostat water bath that temperature is 55 DEG C, and spin concentration bottle carries out refluxing extraction 60min.Refluxing extraction terminates Afterwards, extracting solution is transferred in triangular flask and triangular flask is placed on the thermostat water bath that temperature is 60 DEG C, side heating evaporation chlorine Third extract is made until chloroform evaporated is complete and is concentrated into paste (or blocky) in imitative side stirring.
Preparations shaping step: the first extract, the second extract and third extract are stirred and evenly mixed in advance, primary is made Medicinal extract, then primary extract, Sodium Hyaluronate, carbomer and hydrogel are uniformly mixed, it is modulated into emulsifiable paste shape with glycerol, is obtained The present invention improves the medical facial cold compress gel of sensitive problem.Wherein, primary extract, Sodium Hyaluronate, carbomer and The weight ratio of hydrogel is 10:3:3:20.
Embodiment 4
Material preparation step: weighing the Radix Salviae Miltiorrhizae dried is 5g, Caulis Spatholobi 4g, rhizoma corydalis 15g, rhizome of chuanxiong 8g, Radix Rehmanniae 7g and cynomorium songaricum 4g constituent component A.Weigh the balsam pear 5g dried, imperial tongue 7g, aloe 9g and cassia seed 8g constituent component B.Weigh the pine dried Fragrant 12g, cicada slough 15g, Golden Larch Bark 20g and folium eucalypti 9g constituent component C.
It prepares the first extract step: component A is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:12, the ethyl alcohol that mass fraction is 85% is added into round-bottomed flask, and stirring rod is set and is stirred in a round bottom flask 35min (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into the pipeline system of condensing reflux Standby that round-bottomed flask is placed in 75 DEG C of thermostat water baths at a set of refluxing extraction device, rotation round-bottomed flask carries out refluxing extraction 2h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, filtrate is transferred to In vacuum rotary evaporator, there is wall built-up in rotary evaporation to extracting solution under the conditions of vacuum degree is -0.05MPa and temperature is 65 DEG C Stop when (starting to occur sticky) phenomenon, then add dehydrated alcohol into round-bottomed flask, the addition volume of dehydrated alcohol is concentration 6 times of liquid product vibrate round-bottomed flask and concentrate are uniformly mixed with dehydrated alcohol, stand for 24 hours, be layered, anhydrous The contamination precipitations such as protein, polysaccharide, inorganic salts are precipitated in ethyl alcohol, the effective component being achieved in purified components A.Draw supernatant Liquid is simultaneously transferred on 72 DEG C of thermostat water baths, and heating, stirring are concentrated into and become paste, and the first extract is made as a result,.
It prepares the second extract step: component B is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:12, the ethyl alcohol that mass fraction is 90% is added into round-bottomed flask, and stirring rod is set and is stirred in a round bottom flask 25min (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into the pipeline system of condensing reflux Standby to be placed in round-bottomed flask in the thermostat water bath that temperature is 62 DEG C at a set of refluxing extraction device, rotation round-bottomed flask carries out Refluxing extraction 3.5h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, it will Filtrate is transferred in vacuum rotary evaporator, and rotary evaporation extremely extracts under the conditions of vacuum degree is -0.1MPa and temperature is 52 DEG C There is wall built-up and (starts to occur sticky) to stop when phenomenon in liquid, and concentrate is made.Into concentrate obtained, the hydrochloric acid of addition 4% is molten The ratio between volume of liquid, concentrate and hydrochloric acid solution is 1:4, and the stirring of Bian Tianjia hydrochloric acid solution side stands 1h, obtains acid dissolution part With non-acid dissolution part, taking acid dissolution part pH value is 12 ammonium hydroxide tune pH10.0, continuously adds methylene chloride, wherein acid The volume ratio of dissolution part and methylene chloride is 1:3.5, oscillation mixing, stratification.It draws dichloromethane layer and is transferred to true Empty Rotary Evaporators, setting evaporating temperature are 40 DEG C, and vacuum degree is -0.01MPa, are evaporated under reduced pressure at powdered, are made second and mention Take object.
Preparation third extract step: component C is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) be 1:2.5 amount add 1.5mol/L acetum into round-bottomed flask, according still further to solid-liquid ratio (i.e. the ratio between quality volume It is worth) dehydrated alcohol is added for the amount of 1:12, oscillation mixes.Round-bottomed flask is transferred in Ultrasound Instrument, adjusting ultrasonic power is 200W, ultrasonic extraction 50min.After ultrasonic extraction process, extracting solution is filtered by double gauze, the dregs of a decoction is filtered out, collects Filtrate.Filtrate is transferred in centrifuge tube, centrifuge tube, which is placed in a centrifuge, to be centrifuged, centrifuge RPMs 7000r/min, centrifugation Time is 5min.Centrifuge tube is taken out after centrifugation, absorption supernatant liquor, which is transferred in vacuum rotary evaporator, is condensed into medicinal extract Shape, wherein thickening temperature is 70 DEG C, and vacuum degree is -0.15MPa.The chlorine of 4 times of supernatant liquor volumes is added into concentrate bottle again It is imitative, concentrate bottle is placed in the thermostat water bath that temperature is 60 DEG C, spin concentration bottle carries out refluxing extraction 45min.Refluxing extraction After, extracting solution is transferred in triangular flask and triangular flask is placed on the thermostat water bath that temperature is 65 DEG C, side heating is steamed The stirring of chloroform side is sent out, until chloroform evaporated is complete and is concentrated into paste (or blocky), third extract is made.
Preparations shaping step: the first extract, the second extract and third extract are stirred and evenly mixed in advance, primary is made Medicinal extract, then primary extract, Sodium Hyaluronate, carbomer and hydrogel are uniformly mixed, it is modulated into emulsifiable paste shape with glycerol, is obtained The present invention improves the medical facial cold compress gel of sensitive problem.Wherein, primary extract, Sodium Hyaluronate, carbomer and The weight ratio of hydrogel is 10:8:8:25.
Embodiment 5
Material preparation step: weighing the Radix Salviae Miltiorrhizae dried is 15g, Caulis Spatholobi 2g, rhizoma corydalis 6g, rhizome of chuanxiong 16g, Radix Rehmanniae 10g and lock Positive 8g constituent component A.Weigh the balsam pear 3g dried, imperial tongue 12g, aloe 3g and cassia seed 20g constituent component B.It weighs and dries Rosin 3g, cicada slough 18g, Golden Larch Bark 6g and folium eucalypti 15g constituent component C.
It prepares the first extract step: component A is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:15, the ethyl alcohol that mass fraction is 75% is added into round-bottomed flask, and stirring rod is set and is stirred in a round bottom flask 20min (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into the pipeline system of condensing reflux Standby that round-bottomed flask is placed in 70 DEG C of thermostat water baths at a set of refluxing extraction device, rotation round-bottomed flask carries out refluxing extraction 2.5h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, filtrate is shifted Into vacuum rotary evaporator, rotary evaporation to extracting solution is hung under the conditions of vacuum degree is -0.08MPa and temperature is 60 DEG C Wall (starts to occur sticky) to stop when phenomenon, then dehydrated alcohol is added into round-bottomed flask, and the addition volume of dehydrated alcohol is dense 8 times of contracting liquid product vibrate round-bottomed flask and concentrate are uniformly mixed with dehydrated alcohol, stand for 24 hours, be layered, nothing The contamination precipitations such as protein, polysaccharide, inorganic salts are precipitated in water-ethanol, the effective component being achieved in purified components A.In absorption Clear liquid is simultaneously transferred on 75 DEG C of thermostat water baths, and heating, stirring are concentrated into and become paste, and the first extract is made as a result,.
It prepares the second extract step: component B is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:15, the ethyl alcohol that mass fraction is 75% is added into round-bottomed flask, and stirring rod is set and is stirred in a round bottom flask 20min (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into the pipeline system of condensing reflux Standby to be placed in round-bottomed flask in the thermostat water bath that temperature is 60 DEG C at a set of refluxing extraction device, rotation round-bottomed flask carries out Refluxing extraction 5h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, will be filtered Liquid is transferred in vacuum rotary evaporator, and rotary evaporation is to extracting solution under the conditions of vacuum degree is -0.12MPa and temperature is 50 DEG C There is wall built-up (to start to occur sticky) to stop when phenomenon, concentrate is made.Into concentrate obtained, the hydrochloric acid of addition 0.5% is molten The ratio between volume of liquid, concentrate and hydrochloric acid solution is 1:5, and the stirring of Bian Tianjia hydrochloric acid solution side stands 1h, obtains acid dissolution part With non-acid dissolution part, taking acid dissolution part pH value is 12 ammonium hydroxide tune pH10.4, continuously adds methylene chloride, wherein acid The volume ratio of dissolution part and methylene chloride is 1:5, oscillation mixing, stratification.It draws dichloromethane layer and is transferred to vacuum Rotary Evaporators, it is 42 DEG C that evaporating temperature, which is arranged, and vacuum degree is -0.01MPa, is evaporated under reduced pressure into powdered, obtained second extraction Object.
Preparation third extract step: component C is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) be 1:2 amount add 2mol/L acetum into round-bottomed flask, be according still further to solid-liquid ratio (i.e. the ratio between quality volume value) The amount of 1:15 adds dehydrated alcohol, and oscillation mixes.Round-bottomed flask is transferred in Ultrasound Instrument, adjusting ultrasonic power is 100W, is surpassed Sound extracts 60min.After ultrasonic extraction process, extracting solution is filtered by double gauze, the dregs of a decoction is filtered out, collects filtrate.It will Filtrate is transferred in centrifuge tube, and centrifuge tube, which is placed in a centrifuge, to be centrifuged, centrifuge RPMs 8000r/min, and centrifugation time is 3min.Centrifuge tube is taken out after centrifugation, absorption supernatant liquor, which is transferred in vacuum rotary evaporator, is condensed into medicinal extract shape, In, thickening temperature is 60 DEG C, and vacuum degree is -0.15MPa.The chloroform for adding 5 times of supernatant liquor volumes into concentrate bottle again, will be dense Contracting bottle is placed in the thermostat water bath that temperature is 65 DEG C, and spin concentration bottle carries out refluxing extraction 55min.After refluxing extraction, Extracting solution is transferred in triangular flask and triangular flask is placed on the thermostat water bath that temperature is 70 DEG C, in heating evaporation chloroform Third extract is made until chloroform evaporated is complete and is concentrated into paste (or blocky) in stirring.
Preparations shaping step: the first extract, the second extract and third extract are stirred and evenly mixed in advance, primary is made Medicinal extract, then primary extract, Sodium Hyaluronate, carbomer and hydrogel are uniformly mixed, it is modulated into emulsifiable paste shape with glycerol, is obtained The present invention improves the medical facial cold compress gel of sensitive problem.Wherein, primary extract, Sodium Hyaluronate, carbomer and The weight ratio of hydrogel is 10:10:10:10.
Comparative example 1
Material preparation step: weighing the Radix Salviae Miltiorrhizae dried is 7g, Caulis Spatholobi 6g, rhizoma corydalis 13g, rhizome of chuanxiong 9g, Radix Rehmanniae 5g and cynomorium songaricum 5g constituent component A.Weigh the balsam pear 7g dried, imperial tongue 9g, aloe 7g and cassia seed 12g constituent component B.Weigh the pine dried Fragrant 9g, cicada slough 12g, Golden Larch Bark 16g and folium eucalypti 11g constituent component C.
It prepares extract step: component A, B and C is transferred in casserole medicinal cupping, add 3000ml into the casserole medicinal cupping Pure water (is also required to guarantee water by addition pure water in decoction process), is stirred to be placed on mild fire and decocts 2h, Casserole medicinal cupping is stirred continuously or vibrated in decoction process.After decoction, natural cooling, by decoction liquor double gauze mistake Filter, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick.Wherein, the temperature of reduced pressure is 82 DEG C, is depressurized dense The vacuum degree of contracting is -0.07MPa.
Preparations shaping step: extract, Sodium Hyaluronate, carbomer and hydrogel are uniformly mixed, are modulated into glycerol Emulsifiable paste shape, obtaining the present invention improves the medical facial cold compress gel of sensitive problem.Wherein, primary extract, hyalomitome The weight ratio of sour sodium, carbomer and hydrogel is 10:3:3:20.
Comparative example 2
Material preparation step: weighing the Radix Salviae Miltiorrhizae dried is 7g, Caulis Spatholobi 6g, rhizoma corydalis 13g, rhizome of chuanxiong 9g, Radix Rehmanniae 5g and cynomorium songaricum 5g constituent component A.Weigh the rosin 9g dried, cicada slough 12g, Golden Larch Bark 16g and folium eucalypti 11g constituent component C.
It prepares the first extract step: component A is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) it is 1:10, the ethyl alcohol that mass fraction is 80% is added into round-bottomed flask, and stirring rod is set and is stirred in a round bottom flask 50min (or round-bottomed flask is placed on shaking table between oscillating phase is seasonable).Round-bottomed flask is connected into the pipeline system of condensing reflux Standby that round-bottomed flask is placed in 78 DEG C of thermostat water baths at a set of refluxing extraction device, rotation round-bottomed flask carries out refluxing extraction 1.5h.After refluxing extraction process, mixed liquor is filtered by double gauze, filters out the dregs of a decoction.Filtrate is collected, filtrate is shifted Into vacuum rotary evaporator, rotary evaporation to extracting solution is hung under the conditions of vacuum degree is -0.04MPa and temperature is 68 DEG C Wall (starts to occur sticky) to stop when phenomenon, then dehydrated alcohol is added into round-bottomed flask, and the addition volume of dehydrated alcohol is dense 5 times of contracting liquid product vibrate round-bottomed flask and concentrate are uniformly mixed with dehydrated alcohol, stand for 24 hours, be layered, nothing The contamination precipitations such as protein, polysaccharide, inorganic salts are precipitated in water-ethanol, the effective component being achieved in purified components A.In absorption Clear liquid is simultaneously transferred on 70 DEG C of thermostat water baths, and heating, stirring are concentrated into and become paste, and the first extract is made as a result,.
Preparation third extract step: component C is transferred in round-bottomed flask, according to solid-liquid ratio (i.e. the ratio between quality volume Value) be 1:3 amount add 1mol/L acetum into round-bottomed flask, be according still further to solid-liquid ratio (i.e. the ratio between quality volume value) The amount of 1:10 adds dehydrated alcohol, and oscillation mixes.Round-bottomed flask is transferred in Ultrasound Instrument, adjusting ultrasonic power is 300W, is surpassed Sound extracts 35min.After ultrasonic extraction process, extracting solution is filtered by double gauze, the dregs of a decoction is filtered out, collects filtrate.It will Filtrate is transferred in centrifuge tube, and centrifuge tube, which is placed in a centrifuge, to be centrifuged, centrifuge RPMs 6000r/min, and centrifugation time is 8min.Centrifuge tube is taken out after centrifugation, absorption supernatant liquor, which is transferred in vacuum rotary evaporator, is condensed into medicinal extract shape, In, thickening temperature is 60 DEG C, and vacuum degree is -0.15MPa.The chloroform of 3.5 times of supernatant liquor volumes is added into concentrate bottle again, it will Concentrate bottle is placed in the thermostat water bath that temperature is 55 DEG C, and spin concentration bottle carries out refluxing extraction 60min.Refluxing extraction terminates Afterwards, extracting solution is transferred in triangular flask and triangular flask is placed on the thermostat water bath that temperature is 60 DEG C, side heating evaporation chlorine Third extract is made until chloroform evaporated is complete and is concentrated into paste (or blocky) in imitative side stirring.
Preparations shaping step: the first extract and third extract are stirred and evenly mixed into obtained primary extract in advance, then will be first Grade medicinal extract, Sodium Hyaluronate, carbomer and hydrogel are uniformly mixed, and are modulated into emulsifiable paste shape with glycerol, are obtained improvement of the present invention The medical facial cold compress gel of sensitive problem.Wherein, the weight of primary extract, Sodium Hyaluronate, carbomer and hydrogel Amount is than being 10:3:3:20.
Effect example one
Clinical data: choose in April, 2015 in June, 2018 store be diagnosed as steroid dependent dermatitis patient 160, Wherein female patient 152, male patient 8, average age be (32.8 ± 6.52) year, the course of disease is 2 months~3 years, average (1.2 ± 0.76) year.Female patient is randomly divided into 8 groups, 8 male patients are in addition assigned randomly to eight groups of female patients In, every group 20, be respectively: test group 1, test group 2, test group 3, test group 4, test group 5, control group 1, control group 2 and Positive controls.The general information no significant difference of 8 groups of patients, is comparable.
Treatment method: 20 patients in test group 1 smear improvement sensitive prepared by embodiment 1 in face daily The medical facial cold compress gel 5g of problem applies time 1h or more once a day every time.20 patients in test group 2 are daily It is applied every time once a day in the medical facial cold compress gel 5g that face smears improvement sensitive problem prepared by embodiment 2 Apply time 1h or more.20 patients in test group 3 smear improvement sensitive problem prepared by embodiment 3 in face daily Medical facial cold compress gel 5g apply time 1h or more every time once a day.20 patients in test group 4 are daily in face The medical facial cold compress gel 5g of improvement sensitive problem prepared by embodiment 4 is smeared in portion, once a day, every time when coating Between 1h or more.20 patients in test group 5 smear the doctor of improvement sensitive problem prepared by embodiment 5 in face daily Time 1h or more is applied every time once a day with facial cold compress gel 5g.20 patients in control group 1 apply in face daily The medical facial cold compress gel 5g for smearing the improvement sensitive problem of the preparation of comparative example 1 applies time 1h once a day every time More than.20 patients in control group 2 smear the medical face of improvement sensitive problem prepared by comparative example 2 in face daily Portion cold compress gel 5g applies time 1h or more once a day every time.20 patients in positive controls smear in face daily Compound Dexamethasone Acetate 5g applies time 1h or more once a day every time.Continuous medication 2 weeks, count pretherapy and post-treatment red swelling of the skin, it is scorching hot, Itch and scales of skin that peel off situation, statistical result are shown in Table 2-6.
Evaluation criterion: questionnaire is provided to patient using the form of questionnaire survey, it is pretherapy and post-treatment to record every group of patient The symptoms such as skin of face is red and swollen, scorching hot, itch and the scales of skin that peel off, while the skin lesion calculated after facial skin lesion area and treatment reduces ratio Example.Primary symptom and skin lesion area classification meter minute mark are quasi-, are shown in Table 1.
Table 1
Wherein, the skin lesion grade before treatment is calculated as 3 points.
Table 2
* indicate that the patient after treatment declines significant (P < 0.05) in terms of red swelling of the skin compared to before treatment；* indicates phase Than before treatment, the patient after treatment declines extremely significant (P < 0.01) in terms of red swelling of the skin.
As seen from the results in Table 2, compared with before receiving treatment, the improvement sensitive problem of embodiment 1-5 preparation Medical face cold compress gel has significant curative effect for improving the red swelling of the skin symptom of steroid dependent dermatitis patient, especially in fact The medical facial cold compress gel for applying the improvement sensitive problem of the preparation of example 3,4, with extremely significant improvement red swelling of the skin Effect, red swelling of the skin assessment grade after improvement is close to positive controls.Improvement prepared by comparative example 1 and comparative example 2 is sensitive Property skin problem medical facial cold compress gel it is unobvious for the red swelling of the skin effect for improving steroid dependent dermatitis patient, control Red swelling of the skin assessment grade after treatment is poor.
Table 3
Before * is indicated compared to treatment, the patient after treatment declines extremely significant (P < 0.01) in terms of skin burns.
As seen from the results in Table 3, compared with before receiving treatment, the improvement sensitive problem of embodiment 1-5 preparation Medical face cold compress gel has extremely significant curative effect for the skin burns symptom for improving steroid dependent dermatitis patient.Receive real After the medical facial cold compress gel for treating for applying the improvement sensitive problem of a 1-5 preparation, the scoring etc. after the treatment of patient Grade is close to positive controls, skin burns symptom caused by capable of effectively treating because of steroid dependent dermatitis.Comparative example 1 and right Skin of the medical facial cold compress gel of improvement sensitive problem prepared by ratio 2 for improvement steroid dependent dermatitis patient The scorching hot symptom effect of skin is unobvious, and the skin burns assessment grade after treatment is poor.
Table 4
Before * is indicated compared to treatment, the patient after treatment declines extremely significant (P < 0.01) in terms of pruitus.
As seen from the results in Table 4, compared with before receiving treatment, the improvement sensitive problem of embodiment 1-5 preparation Medical face cold compress gel has extremely significant curative effect for the skin itching symptom for improving steroid dependent dermatitis patient.Receive real After the medical facial cold compress gel for treating for applying the improvement sensitive problem of a 1-5 preparation, the scoring etc. after the treatment of patient Grade is close to positive controls, skin itching symptom caused by capable of effectively treating because of steroid dependent dermatitis.Comparative example 1 and right Skin of the medical facial cold compress gel of improvement sensitive problem prepared by ratio 2 for improvement steroid dependent dermatitis patient Skin pruritis effect is unobvious, and the pruitus assessment grade after treatment is poor.
Table 5
* indicate that the patient after treatment declines significant (P < 0.05) in terms of scaling of skin compared to before treatment.
As seen from the results in Table 5, compared with before receiving treatment, embodiment 1,2,4,5 and comparative example 1 and comparative example 2 are made Scaling of skin of the medical facial cold compress gel of standby improvement sensitive problem for improvement steroid dependent dermatitis patient Symptom does not have significant curative effect.And the medical facial cold compress gel of improvement sensitive problem prepared by embodiment 3 is for changing The scaling of skin symptom of kind steroid dependent dermatitis patient has significant curative effect, close to the therapeutic effect of positive controls.
Table 6
* indicate that the patient after treatment declines significant (P < 0.05) in terms of skin lesion reduction ratio compared to before treatment；* table Show that the patient after treatment declines extremely significant (P < 0.01) in terms of skin lesion reduction ratio compared to before treatment.
As seen from the results in Table 6, compared with before receiving treatment, the improvement sensitive problem of embodiment 1-5 preparation Medical face cold compress gel has significant curative effect, especially embodiment for the skin lesion reduction for improving steroid dependent dermatitis patient The medical facial cold compress gel of the improvement sensitive problem of 2-4 preparation, with extremely significant reduction skin skin lesion area Effect, skin skin lesion assessment grade after improvement is close to positive controls.Improvement prepared by comparative example 1 and comparative example 2 is sensitive Property skin problem medical facial cold compress gel it is unknown for the skin skin lesion area effect for reducing steroid dependent dermatitis patient Aobvious, the skin skin lesion assessment grade after treatment is poor.
Effect example two
After counting 8 groups for the treatment of patients in above-mentioned effect example one, effective patient's number of cases is treated.Herein effectively After referring to each treatment patients, patient skin is in symptoms such as red and swollen, scorching hot, itch, the scales of skin that peel off and skin lesion area reductions It is respectively less than in scoring and is equal to 2, statistics receives effective number of cases after treatment.
Recurrence rate compares: carrying out follow-up follow-up investigation in 3 months after receiving treatment end to above-mentioned effective example.8 groups of trouble There is steroid dependent dermatitis symptom and is calculated as 1 recurrence (including steroid dependent dermatitis disease occur in the effective example of any bit in person Shape 1 time or it is multiple situations such as), count recurrence of the effective example in 8 groups of patients after receiving treatment end in 3 months, Statistical result is shown in Table 7.
Table 7
By above-mentioned 7 result of table it is found that receiving the medical facial cold compress of the improvement sensitive problem of embodiment 1-5 preparation After gel for treating, the effective percentage of steroid dependent dermatitis patient is more than 50%, wherein the improvement for receiving the preparation of embodiment 3 is sensitive Property skin problem medical facial cold compress gel for treating after, the effective percentage of steroid dependent dermatitis patient reaches 70%, close to sun The 80% of property control group.And receive the medical facial cold compress gel for treating of the improvement sensitive problem of the preparation of comparative example 1 and 2 Afterwards, the effective percentage of steroid dependent dermatitis patient is lower, and effect is poor.
By above-mentioned 7 result of table it is found that receiving the medical facial cold compress of the improvement sensitive problem of embodiment 1-5 preparation After gel for treating, the recurrence rate of steroid dependent dermatitis patient is lower (being lower than 10%), far below the 87.5% of positive controls. Show that the medical facial cold compress gel prepared by the present invention for improving sensitive problem is preventing steroid dependent dermatitis from recurring In the case where have apparent advantage, it can be ensured that no longer recurred after treatment patients, fundamentally cure hormonal dependent Dermatitis.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto, The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention Claimed range.

Claims (10)

1. a kind of medical facial cold compress gel for improving sensitive problem, which is characterized in that including activity extract, transparent Matter acid sodium, carbomer and hydrogel；
The activity extract be Radix Salviae Miltiorrhizae, Caulis Spatholobi, rhizoma corydalis, rhizome of chuanxiong, Radix Rehmanniae, cynomorium songaricum, balsam pear, imperial tongue, aloe, cassia seed, Rosin, cicada slough, Golden Larch Bark and folium eucalypti extract；
The activity extract, Sodium Hyaluronate, carbomer and hydrogel weight ratio be 10:1~10:1~10:10~50.
2. the medical facial cold compress gel according to claim 1 for improving sensitive problem, which is characterized in that by weight Part meter is measured, the Radix Salviae Miltiorrhizae is 3~15 parts, and the Caulis Spatholobi is 2~10 parts, and the rhizoma corydalis is 6~20 parts, and the rhizome of chuanxiong is 4 ~16 parts, the Radix Rehmanniae is 1~10 part, and the cynomorium songaricum is 2~8 parts, and the balsam pear is 3~12 parts, and the dragon tongue is 5~12 Part, the aloe is 3~10 parts, and the cassia seed is 5~20 parts, and the rosin is 3~15 parts, and the cicada slough is 4~18 parts, The Golden Larch Bark is 6~24 parts, and the folium eucalypti is 6~15 parts.
3. the medical facial cold compress gel according to claim 2 for improving sensitive problem, which is characterized in that by weight Part meter is measured, the Radix Salviae Miltiorrhizae is 5~10 parts, and the Caulis Spatholobi is 4~8 parts, and the rhizoma corydalis is 10~15 parts, and the rhizome of chuanxiong is 8 ~12 parts, the Radix Rehmanniae is 3~7 parts, and the cynomorium songaricum is 4~6 parts, and the balsam pear is 5~9 parts, and the dragon tongue is 7~10 parts, The aloe is 5~9 parts, and the cassia seed is 8~16 parts, and the rosin is 6~12 parts, and the cicada slough is 9~15 parts, described Golden Larch Bark is 12~20 parts, and the folium eucalypti is 9~12 parts.
4. the medical facial cold compress gel according to claim 3 for improving sensitive problem, which is characterized in that by weight Part meter is measured, the Radix Salviae Miltiorrhizae is 7 parts, and the Caulis Spatholobi is 6 parts, and the rhizoma corydalis is 13 parts, and the rhizome of chuanxiong is 9 parts, the Radix Rehmanniae It is 5 parts, the cynomorium songaricum is 5 parts, and the balsam pear is 7 parts, and the dragon tongue is 9 parts, and the aloe is 7 parts, and the cassia seed is 12 Part, the rosin is 9 parts, and the cicada slough is 12 parts, and the Golden Larch Bark is 16 parts, and the folium eucalypti is 11 parts.
5. the preparation side of the medical facial cold compress gel according to claim 1-4 for improving sensitive problem Method, which comprises the following steps:
Stock: weighing Radix Salviae Miltiorrhizae, Caulis Spatholobi, rhizoma corydalis, rhizome of chuanxiong, Radix Rehmanniae and cynomorium songaricum constituent component A, weigh balsam pear, imperial tongue, aloe and Cassia seed constituent component B weighs rosin, cicada slough, Golden Larch Bark and folium eucalypti constituent component C, component A, B and C is pulverized, and crosses 10 ~40 meshes；
It prepares the first extract: 75~95% ethyl alcohol is added with the solid-liquid ratios of 1:5~15 in component A, stirring, impregnate 20~ After 80min, concentrate is concentrated under reduced pressure into 0.5~2.5h of refluxing extraction at 70~85 DEG C, filtering, filtrate, adds anhydrous second Alcohol standing, Precipitation take supernatant heating to be concentrated into paste, the first extract are made；
It prepares the second extract: 75~95% ethyl alcohol is added with the solid-liquid ratios of 1:4~10 in component B, stirring, impregnate 20~ After 60min, 1~5h of refluxing extraction at 60~70 DEG C, filtering, filtrate are concentrated under reduced pressure to give concentrate, concentrate with 0.5~ 5% dissolving with hydrochloric acid takes lysate part to be adjusted to pH8.6~10.4 with ammonium hydroxide, continuously adds the two of 2~5 times of lysate volume Dichloromethane layer is concentrated under reduced pressure into powdered, obtained second extract for chloromethanes, mixing, layering；
Prepare third extract: by component C with the acetum of 0.5~2mol/L of solid-liquid ratio addition of 1:2~5 and with 1:5 Dehydrated alcohol is added in~15 solid-liquid ratio, and 100~500W ultrasonic extraction time is 10~60min, 3000~8000r/min centrifugation 3~15min, clear liquid is condensed into medicinal extract shape after centrifugation, and medicinal extract chloroform 20~90min of refluxing extraction of 2~5 times of volumes is mentioned It takes liquid in being concentrated into paste on water-bath, third extract is made；
Preparations shaping: the first extract, the second extract, third extract, Sodium Hyaluronate, carbomer and hydrogel are mixed Uniformly, it is modulated into emulsifiable paste shape with glycerol, the medical facial cold compress gel for improving sensitive problem is made.
6. the preparation method of the medical facial cold compress gel according to claim 5 for improving sensitive problem, special Sign is, in preparing the first extract step, 80% ethyl alcohol is added with the solid-liquid ratio of 1:10 in component A, stirring is impregnated After 50min, refluxing extraction 1.5h at 78 DEG C, double gauze filtering, filtrate be transferred in vacuum rotary evaporator be concentrated under reduced pressure at Concentrate, thickening temperature are 68 DEG C, and vacuum degree is -0.04MPa；
Be added 3 times of volumes of concentrate dehydrated alcohol stand, layering, take supernatant be placed on 70 DEG C of thermostat water baths be concentrated into it is thick The first extract is made in paste.
7. the preparation method of the medical facial cold compress gel according to claim 5 for improving sensitive problem, special Sign is, in preparing the second extract step, 85% ethyl alcohol is added with the solid-liquid ratio of 1:8 in component B, 30min is impregnated in stirring Afterwards, refluxing extraction 2.5h at 65 DEG C, filtering, filtrate are transferred in vacuum rotary evaporator and are concentrated under reduced pressure to give concentrate, wherein Thickening temperature is 55 DEG C, and vacuum degree is -0.08MPa.
8. the preparation method of the medical facial cold compress gel according to claim 7 for improving sensitive problem, special Sign is that 1.5% dissolving with hydrochloric acid of concentrate separates lysate part, lysate part is taken to be adjusted to pH9.4 with ammonium hydroxide, after Dichloromethane layer is concentrated under reduced pressure at powdered, is made second by the continuous methylene chloride for being added 4 times of lysate volume, mixing, layering Extract；
Wherein, it is 37 DEG C that temperature, which is concentrated under reduced pressure, and vacuum degree is -0.02MPa.
9. the preparation method of the medical facial cold compress gel according to claim 5 for improving sensitive problem, special Sign is, in preparation third extract step, by component C with the solid-liquid ratio of 1:3 be added 1mol/L acetum and with Dehydrated alcohol is added in the solid-liquid ratio of 1:10, and 300W ultrasonic extraction 35min, 6000r/min are centrifuged 8min, and clear liquid is transferred to after centrifugation Medicinal extract shape is condensed into vacuum rotary evaporator, wherein thickening temperature is 60 DEG C, and vacuum degree is -0.15MPa；
By the medicinal extract chloroform refluxing extraction 60min of 3.5 times of volumes, extracting solution is in being concentrated into thick paste on 45 DEG C of thermostat water baths Shape.
10. the preparation method of the medical facial cold compress gel according to claim 5 for improving sensitive problem, special Sign is, in preparations shaping step, the first extract, the second extract, third extract is mixed in advance, primary leaching is made Cream adds Sodium Hyaluronate, carbomer and hydrogel, is uniformly mixed；
Wherein, the weight ratio of primary extract, Sodium Hyaluronate, carbomer and hydrogel is 10:3:3:20.
CN201811566339.2A 2018-12-19 2018-12-19 A kind of medical facial cold compress gel and preparation method thereof improving sensitive problem Pending CN109498550A (en)

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