CN100386103C - Plaster for relieving asthma and stopping cough and its preparation method - Google Patents
Plaster for relieving asthma and stopping cough and its preparation method Download PDFInfo
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- CN100386103C CN100386103C CNB2006100509411A CN200610050941A CN100386103C CN 100386103 C CN100386103 C CN 100386103C CN B2006100509411 A CNB2006100509411 A CN B2006100509411A CN 200610050941 A CN200610050941 A CN 200610050941A CN 100386103 C CN100386103 C CN 100386103C
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- relieving asthma
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- stopping cough
- cough
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a plaster for relieving asthma and stopping cough, and a preparation method thereof. The plaster for relieving asthma and stopping cough is primarily prepared from the following raw materials: 1.8 to 2.2 of ephedra, 1.8 to 2.2 of white mustard seed, 0.4 to 0.6 of gansui root, 0.9 to 1.1 of pink reineckea herb, 1.4 to 1.6 of perilla fruit, 0.9 to 1.1 of manchurian wildginger, 0.4 to 0.5 of pungent oleaster fruit and 0.9 to 1.1 of japanese ardisia herb. The traditional Chinese medicinal plaster for relieving asthma and stopping cough which is prepared according to the substrate formula and the preparation method of the plaster of the present invention has the advantages of no harmful effect on the stability of sovereign drug and no side effect; the stickiness and the elasticity of the plaster are moderate, no plaster exists on skin and the paste body does not deform. The plaster can be used repeatedly with long drug efficiency and strong slow release function, and can be made into traditional Chinese medicine plaster containing different traditional Chinese medicine components; the clinical treatment indicates that the plaster for relieving asthma and stopping cough has the efficiencies of diffusing the lung, depressing qi, eliminating phlegm and relieving asthma, and can be used for treating asthma, cough, excessive phlegm, etc. with preferable therapeutic effect. During verification, no toxic or side effect, or adverse reaction occurs, and the use is convenient and safe.
Description
Technical field
Patent of the present invention relates to a kind of Chinese herbs paste and preparation method thereof, relates in particular to a kind of to the Chinese herbs paste plaster for relieving asthma and stopping cough and the preparation method of treatment asthma, cough effect are arranged.
Background technology
As everyone knows, what emplastrum meant that medicinal substances extract or chemicals and suitable substrate makes sticks usefulness for skin, can produce a class lamellar external preparation of part or systemic effect.Comprise rubber-emplastrum, cataplasma and patch.
Tradition plaster (ointment medicine, black plaster) is a substrate with fat-soluble material all, and more serious defective is arranged in application: the medicine carrying capacity is little, the transdermal poor performance, irritated, erythra, adhesion fine hair, pollution clothes etc.
Japan has developed the water-soluble base plaster at late nineteen seventies for opening western market, and such emplastrum is listed " Pharmacopeia of Japan " in, " cataplasma " by name.In Japan and west this more series products is arranged.Cataplasma (aqueous plaster) is to be substrate with water-soluble high-molecular compound or hydroaropic substance, close the emplastrum that forms with chemical agent etc. through refining, cataplasma and skin have the compatibility preferably, affinity, ventilative, absorption of perspiration, it is better to repeat to take off pulling property, and drug loading is big, the bioavailability height, pollution clothes not also has and is difficult for advantage hypersensitive.Cataplasma is compared the easier keratodermatitis cell hydration that makes and is expanded with rubber plaster, black plaster, help the Transdermal absorption of medicine, and curative effect is greatly improved, and is particularly suitable for all kinds of Chinese medical concrete patches, three-waste free pollution in the production.The water-soluble base applied range, water solublity, fat-soluble medicine all can adopt, and are the desirable regeneration products that replaces traditional plaster.Consulting " 2000 editions one one of Pharmacopoeia of People's Republic of China " recently, increased cataplasma under the rules of preparations item of appendix, but there is not the cataplasma kind to record, simultaneously also there has been the patent application of cataplasma to occur in China, for being called " a kind of Chinese medicine patcher for the treatment of asthma and preparation method thereof ", the CN200410091835.9 name it is introduced that this invention relates to a kind of medicine for the treatment of asthma and preparation method thereof, particularly treats Chinese medicine patcher of asthma and preparation method thereof as number of patent application.This invention is prepared into extractum by extraction and separation technology with Rhizoma Corydalis, Herba Asari, Radix Kansui, Semen Sinapis Albae in the Semen Sinapis Albae side of being coated with of " the Zhang Shi doctor is logical ", and adds the transdermal penetrating agent, is prepared into the flat cataplasma of cough with asthma then.The flat cataplasma of cough with asthma have dosage accurate, easy to use, can take off subsides repeatedly, produce advantages such as feasible greatly.
Summary of the invention
The object of the present invention is to provide a kind of patch product---plaster for relieving asthma and stopping cough and prepare the method for cataplasma, clinical practice in clinically as the diseases caused by exogenous pathogenic factor bronchitis, asthmatic bronchitis, diseases such as emphysema, cardiac asthma and pneumonia.Be substrate with the water-soluble high-molecular material in the cataplasma of this method preparation, add medicine, through refining close, be coated with, technology such as shearing is made into external use plaster, its host material can absorb and carry the Chinese medicine extract that comprises multiple water solublity and liposoluble constituent better, and can be fast, the effective ingredient that absorbed in the release matrix enduringly penetrates skin and enters and reach therapeutic effect in stopping.
Plaster for relieving asthma and stopping cough of the present invention, form by medicinal substances extract or chemicals and suitable substrate, the medicinal material extract composition formula that is it by: Herba Ephedrae 1.8～2.2: Semen Sinapis Albae 1.8～2.2: Radix Kansui 0.4～0.6: Herba Reineckeae Carneae 0.9～1.1: Fructus Perillae 1.4～1.6: Herba Asari 0.9～1.1: Fructus Elaeagni 0.4～0.5: Herba Ardisiae Japonicae 0.9～1.1 (weight ratio) is formed, with the water-soluble high-molecular material is main matrix, add drug extract, through refining close, be coated with, shear, selection, package handling operation make the external preparation plaster for relieving asthma and stopping cough.
Above-mentioned plaster for relieving asthma and stopping cough, the best medical material prescription that is it are by Herba Ephedrae 2000: Semen Sinapis Albae 2000: Radix Kansui 500: Herba Reineckeae Carneae 1000: Fructus Perillae 1500: Herba Asari 1000: Fructus Elaeagni 500: Herba Ardisiae Japonicae 1000 (weight ratio) is formed.
Above-mentioned plaster for relieving asthma and stopping cough, the water-soluble high-molecular material substrate that is it are formulated by gelatin 3.9～7.3%, polyvinyl alcohol 3.2～6.2%, sodium carboxymethyl cellulose 1.9～2.5%, Oleum Ricini 1.6～2.8%, sodium polyacrylate 0.96～1.43%, tween 80 1.15～1.72%, sorbic acid 0.07～0.105%, Kaolin 3.5～4.8%, glycerol 6.3～10.2%, tartaric acid 7.45～12.35%, sorbitol 1.38～3.80%, stomach dissolution type film coating powder 15.6～22.6%, distilled water 38～52%.
The preparation method of above-mentioned plaster for relieving asthma and stopping cough, so preparation method is being divided into:
1, Chinese crude drug extractum extraction process
With the Chinese crude drug of medicinal material extract composition formula pulverize, after the weighing, the multipotency extraction pot of packing into, 65～70% the alcohol dipping that adds for the first time 7～8 times of amounts is after 6～8 hours, adopt the reflux, extract, mode, reflux, extract, 6 hours adds for the second time 6～7 times of amount 50～60% alcohol reflux 2 hours, and it is 1.20 clear paste that merging filtrate is concentrated in the time of 60 ℃ relative density, reclaiming ethanol preserves standby, at last that extractum is standby with 200～400 mesh filter screens filtration back sealing;
2, substrate and ointment preparation, calendering process
(1) matrix formulations: the catablasm base material prescription that the present invention relates to is
Gelatin 3.9～7.3%, polyvinyl alcohol 3.2～6.2%, sodium carboxymethyl cellulose 1.9～2.5%, Oleum Ricini 1.6～2.8%, sodium polyacrylate 0.96～1.43%, tween 80 1.15～1.72%, sorbic acid 0.07～0.105%, Kaolin 3.5～4.8%, glycerol 6.3～10.2%, tartaric acid 7.45～12.35%, sorbitol 1.38～3.80%, stomach dissolution type film coating powder 15.6～22.6%, distilled water 38～52%;
(2) preparation method: the catablasm base material that the present invention relates to prepares the system method and is
According to the matrix formulations weighing, with gelatin, polyvinyl alcohol and sodium carboxymethyl cellulose are mixed with colloidal sol respectively, after the dissolving of colloid material, add successively according to above-mentioned prescription, stir, add stomach dissolution type film coating powder at last and supply distilled water, when joining material in the stirred vessel successively, mixing speed increases thereupon, stir initial speed setting at 100～150rpm., a kind of material of every then adding increases rotating speed 60～80rpm., and stir 6～9min and continue to stir 15～20min until mixing speed being increased to 1000～1200rpm., promptly get catablasm base material of the present invention;
3, plaster for relieving asthma and stopping cough preparation, mixing
Catablasm base material is mixing finish after, add above-mentioned standby extractum simultaneously, continuation is stirred 15～20min with 1000～1200rpm. rotating speed, promptly obtains the plaster for relieving asthma and stopping cough invented, then by be coated with, cut, selection, package handling operation obtain the plaster for relieving asthma and stopping cough product.
The Chinese herbs paste plaster for relieving asthma and stopping cough that adopts catablasm base material prescription of the present invention and compound method to make does not have harmful effect to principal agent stability, has no side effect, and cataplasma viscosity, elasticity are moderate, and no remaining on the skin, mastic is indeformable; Can notice repeatedly, drug release is long-acting, slow releasing function is strong; Be applicable to the Chinese medicine patcher of making different Chinese medicine ingredients.
Chinese crude drug wherein has Herba Ephedrae, Semen Sinapis Albae, Radix Kansui, Herba Reineckeae Carneae, Fructus Perillae, Herba Asari, Fructus Elaeagni, Herba Ardisiae Japonicae, and their nature and flavor and function are described below:
Herba Ephedrae: have another name called numb QINGGEN.Herb stem for Ephedraceae plant plait Herba Ephedrae, Casuarina equisetifolia L. or epheday intermedia.Nature and flavor: arduous, warm.Function cures mainly: diaphoresis, relieving asthma, diuretic.The cold table that cures the wound is real, and fever with chills is lossless, headache nasal obstruction, arthralgia; Cough and asthma.The edema due to wind pathogen edema, dysuria.
Semen Sinapis Albae: different name hot food.For seed, the seed of crucifer Caulis et Folium Sinapis albee is spheroidal, 1.1～2.0～2.5 millimeters of diameters are big than Semen Sinapis.Nature and flavor: hot, warm nontoxic.Function cures mainly: promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.Harness the river generalized edema with distention of the chest and abdomen, control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain etc.
Radix Kansui: have another name called main field, Chong Ze, swollen hands Hua Gen etc.Root for the euphorbia plant Radix Kansui.Perennial meat draft, high 20～40 centimetres, herb contains milk.Nature and flavor: bitter sweet, cold poisonous.Function cures mainly: removing water retention by purgation drink, removing mass gather, lead to two just.Harness the river generalized edema with distention of the chest and abdomen, blocked-up chest, lumps in the chest and abdomen, constipation and anuresis etc.
Herba Reineckeae Carneae: different name ocean Herba Reineckeae Carneae, Chinagreen Herb, little Herba Polygoni Runcinati etc.Be liliaceous plant Herba Reineckeae Carneae whole herb with root, evergreen perennial herb.Nature and flavor: sweet, cool.Function cures mainly: lung heat clearing, cough-relieving, treating blood disorders, detoxifcation.Control cough due to lung-heat, haematemesis etc.
Fructus Perillae: have another name called Fructus Perillae, FRUCTUS PERILLAE, wild flax etc.Fruit for labiate wrinkle, sharp Folium Perillae the Liao Dynasty etc.The annual draft of climbing up by holding on to.Nature and flavor: hot, warm.Function cures mainly: the therapeutic method to keep the adverse QI flowing downwards, expectorant, lung moistening, wide intestinal.
Herba Asari: have another name called Xiao Xin, Herba Ceratophylli Demeersi, Kingdonia uniflora etc.Whole herb with root for aristolochiaceae plant Herba Asari or magnificent Herba Asari.The annual draft of climbing up by holding on to.Nature and flavor: hot, warm.Function cures mainly: dispel the wind, cold expelling, Hang Shui, have one's ideas straightened out.Control air-cooled headache, phlegm retention cough with dyspnea etc.
Fructus Elaeagni: have another name called Lu Douzi, the ruined son of Pu, sheep milk milk, sheep breast milk milk etc.Fruit for Elaeangnaceae plant Fructus Elaeagni.Evergreen shrubs, up to 4 meters, common spinosity.Nature and flavor: sour and astringent, flat.Function cures mainly: control dysentery, quench one's thirst, breath with cough.
Herba Ardisiae Japonicae: have another name called Herba Ardisiae Japonicae, PINGDIMU, Herba Ardisiae Japonicae, Herba Ardisiae Japonicae lotus etc.Stem and leaf for Myrsinacea plant Herba Ardisiae Japonicae.Evergreen undershrub, high about 10～30 centimetres.Nature and flavor: bitter, flat.Function cures mainly: antitussive, eliminate the phlegm, invigorate blood circulation, diuresis, detoxifcation.Control chronic bronchitis pulmonary tuberculosis cough hemoptysis, haematemesis, hepatitis, dysentery acute and chronic nephritis, hypertension, swell and ache etc.
These several Chinese crude drugs all are the conventional Chinese medicine material, in the Chinese medicine proved recipe in many places, all using respectively, in this plaster for relieving asthma and stopping cough, use, have no side effect, cataplasma of the present invention, have rapid-action, the effect stablize, carry taking convenience, reusable characteristics, welcome by patient.
The specific embodiment
Embodiment 1: the catablasm base material preparation
(1) weighing: gelatin 0.450kg, polyvinyl alcohol 0.380kg, sodium carboxymethyl cellulose 0.205kg, Oleum Ricini 0.260kg, sodium polyacrylate 0.122kg, tween 80 0.159kg, sorbic acid 0.009kg, Kaolin 0.460kg, glycerol 0.660kg, tartaric acid 0.760kg, sorbitol 0.285kg, stomach dissolution type film coating powder 2.050kg, distilled water 4.200kg.
(2) gelatin, polyvinyl alcohol and sodium carboxymethyl cellulose are mixed with colloidal sol respectively.
(3) add successively in the container by the weighing order again, stir initial speed setting at 100rpm., a kind of material of every then adding increases rotating speed 60～80rpm., and stirs 6～9min.Treat that reinforced finishing rises to 1000～1200rpm. with speed of agitator, continue to stir 8～12min, promptly get catablasm base material of the present invention.
Embodiment 2: the preparation of medicament in the plaster for relieving asthma and stopping cough
1, plaster for relieving asthma and stopping cough extractum preparation:
(1) Chinese medicine weighing: Herba Ephedrae 2000g, Semen Sinapis Albae 2000g, Radix Kansui 500g, Herba Reineckeae Carneae 1000g Fructus Perillae 1500g, Herba Asari 1000g, Fructus Elaeagni 500g, Herba Ardisiae Japonicae 1000g.
(2) extractum extracts, after above-mentioned medical material weighing, the multipotency extraction pot of packing into, 65～70% the alcohol dipping that adds 9.5 * 8kg for the first time adopted the reflux, extract, mode after 6～8 hours, reflux, extract, 6 hours, for the second time add 9.5 * 6kg, 50～60% alcohol reflux 2 hours, merging filtrate is concentrated into the clear paste that relative density is 1.20 (60 ℃), and the ethanol of recovery is preserved standby, at last extractum is filtered the standby 2.15kg extractum that obtains of back sealing with 200～400 mesh filter screens, stand-by;
2, catablasm base material preparation, mixing
(1) weighing: gelatin 0.450kg, polyvinyl alcohol 0.380kg, sodium carboxymethyl cellulose 0.205kg, Oleum Ricini 0.260kg, sodium polyacrylate 0.122kg, tween 80 0.159kg, sorbic acid 0.009kg, Kaolin 0.460kg, glycerol 0.660kg, tartaric acid 0.760kg, sorbitol 0.285kg, stomach dissolution type film coating powder 2.050kg, distilled water 4.200kg.
(2) gelatin, polyvinyl alcohol and sodium carboxymethyl cellulose are mixed with colloidal sol respectively.
(3) add successively in the container by the weighing order again, stir initial speed setting at 100rpm., a kind of material of every then adding increases rotating speed 60～80rpm., and stirs 6～9min.Treat that reinforced finishing rises to 1000～1200rpm. with speed of agitator, continue to stir 8～12min, promptly get catablasm base material of the present invention.
3, plaster for relieving asthma and stopping cough preparation, mixing
Catablasm base material is mixing finish after, add 2.10kg plaster for relieving asthma and stopping cough extractum, continuation is stirred 15～20min with 1000～1200rpm. rotating speed, promptly obtains the plaster for relieving asthma and stopping cough invented, is coated with then, cuts, selection, package handling operation.
Plaster for relieving asthma and stopping cough is to serve as according to getting in conjunction with traditional popular prescription with " 2000 editions one one of Pharmacopoeia of People's Republic of China ", Main Ingredients and Appearance is a Herba Ephedrae, Semen Sinapis Albae, Radix Kansui, Fructus Perillae, Herba Asari, Fructus Elaeagni etc., plaster for relieving asthma and stopping cough is under the prerequisite that does not change its indication, by flavour of a drug that it is write out a prescription, the improvement of compatibility, use modern extraction means and preparation process, it is prepared into external use plaster, improved preparation level, avoided the blood drug level that causes because of oral medication unbalanced, dosage is big, side effect that non-target organs absorbs and gastrointestinal disturb and stimulate, the first-pass effect by gastrointestinal and liver not because of the absorption of medicine, reduced the loss of pharmaceutical compositions, active ingredient is more stable enters blood flow, make blood level be stabilized in valid density, and then keep and improved drug effect.
The situation report that plaster for relieving asthma and stopping cough is carried out clinical treatment observation is as follows:
1 is tried disease: diseases such as full vexed, gurgling with sputum of asthma, cough, abundant expectoration, chest and diaphragm and bronchitis.
2 diagnostic criterias: asthma is breathing tachypnea or to stridulate soundly, and opening mouth and lifting shoulder due to dyspnea when serious is difficult to flat crouching and is a class illness of feature.Clinically as bronchitis, emphysema, cardiac asthma and pneumonia, lung abscess, pulmonary tuberculosis, diseases such as pneumosilicosis in that the Tachypneic stage takes place, can be carried out diagnosis and treatment based on an overall analysis of the illness and the patient's condition by assertive evidence.
3 differentiation of symptoms and signs for classification of syndrome excess-dyspnea: wind-cold affecting lung, wind-heat invading the lung, the turbid resistance of expectorant is useless; Dyspnea due to deficiency: the deficiency of the lung, suffer from a deficiency of the kidney.
4 are tried case selects: meet diagnostic criteria, the patient age of differentiation of symptoms and signs for classification of syndrome, male or female
5 exclusion standards: (1) does not meet diagnostic criteria, distinguishes the patient of disease typing.(2) Western medicine diagnose has severe cardiac, liver, kidney device disease patient, psychotic.(3) gestation or women breast-feeding their children and allergic constitution person.(4) can not guarantee to require according to plan to finish the checking observer.
6 test group
Cough with asthma patient due to 400 exception sense bronchitis, the chronic asthmatic bronchitis is used plaster for relieving asthma and stopping cough, and 160 examples are used other congenerous oral formulations to compare group to carry out clinical experiment.Wherein male 314 examples, women 246 examples, the oldest 87 years old, minimum 3 years old.Distinguish the disease typing: wind-cold affecting lung 75 examples, wind-heat invading the lung 56 examples, turbid phlegm obstructing in the lung 205 examples, insufficiency of lung-QI 131 examples are suffered from a deficiency of the kidney to lose and are received 93 examples.
7 verification methods:
Adopt laboratory clinical trial mode.
8 administrated methods, dosage and observation item
Plaster for relieving asthma and stopping cough experimental group: 400 examples.External.Tear release thin film, ointment is affixed on two " Dingchuan " caves, changed dressings once in per 24 hours, 10 days is a course of treatment.If skin pruritus occurs in the medication process, ointment can be moved to " fei shu " cave, " every Yu " cave.
Non-this product experimental group: 160 examples.Oral.Amount with reference to the active ingredient of this test is taken.
9 observation items
Observe treatment front and back asthma, cough, amount of expectoration variation, observe untoward reaction, and perform record.
10 curative effects are judged: be divided into (1) produce effects: asthma, cough obviously alleviate, and sputum obviously reduces, or duration of seizure obviously shortens, or outbreak obviously prolongs blanking time.(2) effective: asthma, cough alleviate, and sputum reduces, or duration of seizure has and shortens or outbreak has prolongation blanking time.(3) invalid: asthma, the no change of coughing, spit.
Statistical result is observed in 11 checking result verification treatments
400 example checking treatment observed result statistics
Clinical diagnosis example digital display is imitated enabledisable obvious effective rate total effective rate
Wind-cold affecting lung 54 40 14 0 74.1 100.0
Wind-heat invading the lung 41 0 27 14 35.9 65.9
Turbid phlegm obstructing in the lung 145 39 94 12 26.9 91.7
Deficiency of the lung less than 83 16 67 0 19.3 100.0
Suffer from a deficiency of the kidney to lose and receive 77 0 64 13 0.0 83.1
Add up to 400 95 266 39 23.8 90.3
12 are suitable for plaster for relieving asthma and stopping cough and certain kind oral formulations curative effect comparision
Test group produce effects enabledisable total effective rate
Use antiasthmatic-antitussive subsides groups (400 example) 23.75% 66.5% 9.75% 90.25%
Use XIAOKECHUAN group (160 example) 48.1% 36.8% 15.1% 84.9%5.3
13 model cases
Thank to XX, man, 56 years old.Live Ci An lane, Guiyang.The patient in calendar year 2001 JIUYUE 9 days because of bronchial asthma.The patient is because of being affected by the cold accidentally 7 days, and self-induction lung chest and diaphragm is full vexed, and rapid breathing is coughed thin and whitish sputum, the aversion to cold headache.Check thin white fur of tongue, floating and tense pulse.Western medicine diagnose: bronchial asthma.Tcm diagnosis: wind-cold affecting lung.Employing is relievingd asthma, and ending roars pastes external.Tear release thin film, ointment is affixed on two " Dingchuan " caves, per 24 hours Adhesive plaster with changable medicine once.Institute's check afterwards on the 10th, symptom all has alleviation, therapeutic outcome: produce effects.
14 checking interpretation of result and conclusions
Differentiation of symptoms and signs for classification of syndrome curative effect: this test case 400 examples, wind-cold affecting lung 54 examples, total effective rate 100%; Wind-heat invading the lung 41 examples, total effective rate are 65.9%; Turbid phlegm obstructing in the lung 145 examples, total effective rate are 91.7%; Deficiency of the lung less than 83 examples, total effective rate are 100%; Suffer from a deficiency of the kidney to lose and receive 77 examples, total effective rate is 83.1%.This test case 400 examples, produce effects 95 examples, effective 266 examples, invalid 39 examples, obvious effective rate is 23.8%, total effective rate is 90.3%.The checking result shows that plaster for relieving asthma and stopping cough has the effect that the dispersing and descending lung-QI eliminating phlegm is relievingd asthma, and is used for the treatment of asthma, is the curative effect preferably that has of symptoms such as asthma, cough, abundant expectoration to clinical manifestation.Do not see untoward reaction such as malicious pair in the checking, easy to use, safe.
Claims (4)
1. plaster for relieving asthma and stopping cough, form by medicinal substances extract and suitable substrate, the medicinal material extract composition formula that it is characterized in that it is by crude drug: Herba Ephedrae 1.8～2.2: Semen Sinapis Albae 1.8～2.2: Radix Kansui 0.4～0.6: Herba Reineckeae Carneae 0.9～1.1: Fructus Perillae 1.4～1.6: Herba Asari 0.9～1.1: Fructus Elaeagni 0.4～0.5: Herba Ardisiae Japonicae 0.9～1.1 weight ratio is formed, with the water-soluble high-molecular material is main matrix, add drug extract, through refining close, be coated with, shear, selection, package handling operation make the external preparation plaster for relieving asthma and stopping cough.
2. plaster for relieving asthma and stopping cough according to claim 1, the crude drug prescription that it is characterized in that it are by Herba Ephedrae 2000: Semen Sinapis Albae 2000: Radix Kansui 500: Herba Reineckeae Carneae 1000: Fructus Perillae 1500: Herba Asari 1000: Fructus Elaeagni 500: Herba Ardisiae Japonicae 1000 weight ratios are formed.
3. plaster for relieving asthma and stopping cough according to claim 1, the water-soluble high-molecular material substrate that it is characterized in that it is by gelatin 3.9～7.3%, polyvinyl alcohol 3.2～6.2%, sodium carboxymethyl cellulose 1.9～2.5%, Oleum Ricini 1.6～2.8%, sodium polyacrylate 0.96～1.43%, tween 80 1.15～1.72%, sorbic acid 0.07～0.105%, Kaolin 3.5～4.8%, glycerol 6.3～10.2%, tartaric acid 7.45～12.35%, sorbitol 1.38～3.80%, stomach dissolution type film coating powder 15.6～22.6%, distilled water 38～52% is formulated.
4. the preparation method of plaster for relieving asthma and stopping cough according to claim 1 is characterized in that it being that preparation method is divided into:
1) Chinese crude drug extractum extraction process
After the Chinese crude drug pulverizing weighing with the medicinal material extract composition formula, the multipotency extraction pot of packing into, 65～70% the alcohol dipping that adds for the first time 7～8 times of amounts is after 6～8 hours, adopt the reflux, extract, mode, reflux, extract, 6 hours adds for the second time 6～7 times of amount 50～60% alcohol reflux 2 hours, and it is 1.20 clear paste that merging filtrate is concentrated in the time of 60 ℃ relative density, reclaiming ethanol preserves standby, at last that extractum is standby with 200～400 mesh filter screens filtration back sealing;
2) substrate and ointment preparation, calendering process
(1) matrix formulations: the catablasm base material prescription that the present invention relates to is
Gelatin 3.9～7.3%, polyvinyl alcohol 3.2～6.2%, sodium carboxymethyl cellulose 1.9～2.5%, Oleum Ricini 1.6～2.8%, sodium polyacrylate 0.96～1.43%, tween 80 1.15～1.72%, sorbic acid 0.07～0.105%, Kaolin 3.5～4.8%, glycerol 6.3～10.2%, tartaric acid 7.45～12.35%, sorbitol 1.38～3.80%, stomach dissolution type film coating powder 15.6～22.6%, distilled water 38～52%;
(2) preparation method: the catablasm base material preparation method that the present invention relates to is
According to the matrix formulations weighing, with gelatin, polyvinyl alcohol and sodium carboxymethyl cellulose are mixed with colloidal sol respectively, after the dissolving of colloid material, add successively according to above-mentioned prescription, stir, add stomach dissolution type film coating powder at last and supply distilled water, when joining material in the stirred vessel successively, mixing speed increases thereupon, stir initial speed setting at 100～150rpm., a kind of material of every then adding increases rotating speed 60～80rpm., and stir 6～9min and continue to stir 15～20min until mixing speed being increased to 1000～1200rpm., promptly get catablasm base material of the present invention;
3) plaster for relieving asthma and stopping cough preparation, mixing
Catablasm base material is mixing finish after, add above-mentioned standby extractum simultaneously, continuation is stirred 15～20min with 1000～1200rpm. rotating speed, promptly obtains the plaster for relieving asthma and stopping cough invented, then by be coated with, cut, selection, package handling operation obtain the plaster for relieving asthma and stopping cough product.
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| CN1947754B (en) * | 2006-10-23 | 2010-09-29 | 北京羚锐伟业科技有限公司 | Medicine for treating infantile asthma and its preparation method |
| CN101082053B (en) * | 2007-04-30 | 2010-05-26 | 哈尔滨工业大学 | Biofermentation method of foodstuff garbage |
| CN104224979B (en) * | 2014-07-23 | 2018-01-16 | 江苏七O七天然制药有限公司 | Chinese medicine patcher of acupoint application treatment pulmonary emphysema and preparation method thereof |
| CN105434490A (en) * | 2014-09-30 | 2016-03-30 | 陆超 | Medicine for treating chronic bronchitis |
| CN105963452A (en) * | 2016-06-24 | 2016-09-28 | 南阳医学高等专科学校第附属医院 | Traditional Chinese medicine patch for treating infantile cold cough and preparation method thereof |
| CN109498787A (en) * | 2018-12-24 | 2019-03-22 | 右江民族医学院 | A kind of Chinese medicine composition for oral administration and sticking combination for treating laryngeal cough |
| CN111358913A (en) * | 2020-04-03 | 2020-07-03 | 上海市浦东新区中医医院 | Blood stasis-removing channel-warming plaster and preparation method thereof |
| CN112156148A (en) * | 2020-09-22 | 2021-01-01 | 上海市浦东新区光明中医医院 | Preparation method of cataplasm patch and cataplasm patch prepared by same |
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