CN105963452A - Traditional Chinese medicine patch for treating infantile cold cough and preparation method thereof - Google Patents
Traditional Chinese medicine patch for treating infantile cold cough and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine patch for treating infantile cold cough and a preparation method thereof. The traditional Chinese medicine patch comprises the following raw materials in parts by weight: 10-20 parts of ephedra, 10-20 parts of cassia twig, 7-15 parts of cynanchum glaucescens, 8-15 parts of pinellia ternata, 6-9 parts of radix asteris, 10-16 parts of perilla leaves, 6-12 parts of rhizoma belamcandae, 5-13 parts of tussilago farfara, 3-7 parts of tamarisk, 4-8 parts of radix peucedani, 4-8 parts of platycodon grandiflorum, 1-5 parts of peony, 1-5 parts of schisandra chinensis, 10-20 parts of liquorice, 40-60 parts of glycerinum and 1-5 parts of sodium polyacrylate. The pathogenic causes and the pathogenesis of the infantile cold cough are researched aiming at pathogenic factors causing the infantile cold cough, an idea of traditional Chinese medicine treatment based on syndrome differentiation is adopted, benefiting Qi, relieving exterior syndrome, regulating the flow of Qi and reducing phlegm are taken as main treatment methods, and a traditional Chinese medicine formula theory of 'monarch, minister, assistant and guide' is adopted for drug use, so that the purpose of effectively treating the infantile cold cough is achieved.
Description
Technical field
The present invention relates to a kind of Chinese medicine patch treating cough, especially relate to a kind of Chinese medicine patch treating children's cough due to wind and cold and preparation method thereof.
Background technology
Cough due to wind and cold is a kind of the most sick, and it is because wind and cold and violates lung, and extremely, symptoms including cough frequency is made, thin white phlegm, stuffy nose with watery discharge, and itching throat is low voice speaking in impaired depurative descending of lung QI institute, and such as the exterior tightened by pathogenic windcold, space between skin and muscles is inaccessible, then disease sees that aversion to cold is lossless, head-body-pain, light red tongue, white and thin fur, floating and tense pulse.For infant, on the one hand wind and cold and be generally not suitable for using central antitussive when coughing, such as codeine, carbetapentane citrate, Ethanedisulfonate etc., the respiratory system of infant is grown the most immature, coughre flex is poor, air flue luminal stenosis, rich blood vessel, ciliary movement is poor, sputum is difficult to discharge, if a cough, just stronger antitussive is given, though cough is temporarily stopped, but the contraction wriggling function of the fortune expectorant function of the ciliated epithelial cell on tracheal mucosa and bronchial smooth muscle is inhibited, sputum can not be discharged smoothly, a large amount of sputums are accumulated in trachea and bronchus, affect respiratory function；On the other hand because of infant treat cough at home time, medication is easy to produce vomiting, makes medicine feed highly difficult, therefore needs a kind of external application medicine treating infantile cough badly and improves current infantile cough and be difficult to the present situation of medication.
The Chinese patent of Application No. 2014102284737, discloses a kind of Chinese herbs paste treating childhood chronic cough, takes Rhizoma Imperatae 0.5-1.5
Part, Radix Raphani 5-10 part, Flos Gomphrenae 8-12 part, Radix Salviae Miltiorrhizae 1-5 part, Retinervus Luffae Fructus 5-9 part, Radix Scrophulariae 1-5 part, Radix Paeoniae Rubra 1-3 part, Pumex 3-8 part, Bulbus Fritillariae Cirrhosae 3-8 part, Flos Farfarae 3-8 part, Herba Euphorbiae Helioscopiae 1-3 part, Bulbus Lilii 5-10 part, Lapis Micae Aureus 1-5 part, Sargassum 2-7 part, go the removal of impurity, after cleaning-drying, grind to form 200-300
Purpose powder, under the conditions of 50-60 DEG C, little fire is fried to brown color, is subsequently adding Oleum Sesami 18-25
Part furnishing pasty state, spreads upon equably on medical proof fabric, uses non-textile mulch medicine, be Chinese herbs paste of the present invention.The Chinese patent of Application No. 2011100650970, disclosing a kind of Chinese medicine treating infantile cough, the Chinese medicinal components that the Chinese medicine of this treatment infantile cough is made up of following weight ratio forms: Herba Ephedrae 1-4 part, Semen Armeniacae Amarum 5-11 part, Radix Glycyrrhizae 1-4 part, Semen Trichosanthis 4-10 part, Pericarpium Citri Reticulatae 1-7 part, Radix Peucedani 3-9 part, Rhizoma Belamcandae 7-13 part, Gypsum Fibrosum 9-15 part, Herba Lophatheri 2-8 part, Radix Asteris 3-7 part, Radix Platycodonis 3-12 part and Herba Albiziae 21-28 part.But rarely have the Chinese medicine patch seeing special for treating children's cough due to wind and cold in the market, and the most existing Chinese herbs paste is not ideal enough in the effect of clinical treatment children's cough due to wind and cold, can only to a certain extent relief of symptoms and can not get cure, affect infant healthy.
Summary of the invention
In view of this, it is an object of the invention to for the deficiencies in the prior art, thering is provided a kind of Chinese medicine patch treating children's cough due to wind and cold and preparation method thereof, solve children's cough due to wind and cold and be difficult to medication, existing Chinese herbs paste is in the dissatisfactory problem of effect of clinical treatment children's cough due to wind and cold.
For reaching above-mentioned purpose, the present invention by the following technical solutions:
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: Herba Ephedrae 10-20 part, Ramulus Cinnamomi 10-20 part, Rhizoma Cynanchi Stauntonii 7-15 part, Rhizoma Pinelliae 8-15 part, Radix Asteris 6-9 part, Folium Perillae 10-16 part, Rhizoma Belamcandae 6-12 part, Flos Farfarae 5-13 part, Cacumen Tamaricis 3-7 part, Radix Peucedani 4-8 part, Radix Platycodonis 4-8 part, Radix Paeoniae 1-5 part, Fructus Schisandrae Chinensis 1-5 part, Radix Glycyrrhizae Preparata 10-20 part, glycerol 40-60 part and sodium polyacrylate 1-5 part.
Preferably, including the raw material of following weight portion: Herba Ephedrae 13-17 part, Ramulus Cinnamomi 13-17 part, Rhizoma Cynanchi Stauntonii 10-12 part, Rhizoma Pinelliae 11-13 part, Radix Asteris 7-8 part, Folium Perillae 12-14 part, Rhizoma Belamcandae 8-10 part, Flos Farfarae 8-10 part, Cacumen Tamaricis 4-6 part, Radix Peucedani 5-7 part, Radix Platycodonis 5-7 part, Radix Paeoniae 2-4 part, Fructus Schisandrae Chinensis 2-4 part, Radix Glycyrrhizae Preparata 13-17 part, glycerol 45-55 part and sodium polyacrylate 2-4 part.
Preferably, including the raw material of following weight portion: 15 parts of Herba Ephedrae, Ramulus Cinnamomi 15 parts, Rhizoma Cynanchi Stauntonii 11 parts, the Rhizoma Pinelliae 12 parts, Radix Asteris 9 parts, Folium Perillae 13 parts, Rhizoma Belamcandae 9 parts, Flos Farfarae 9 parts, Cacumen Tamaricis 5 parts, Radix Peucedani 6 parts, Radix Platycodonis 6 parts, Radix Paeoniae 3 parts, Fructus Schisandrae Chinensis 3 parts, Radix Glycyrrhizae Preparata 15 parts, glycerol 50 parts and sodium polyacrylate 3 parts.
Its preparation method, comprises the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata by formula and mix, add the water of 15-20 times of medical material gross weight, after soaking 30-60min, decoct 2-4 hour, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.36-1.40 relative to water；Being dried by the filtering residue obtained in step (2), be then ground to powder, under the conditions of 60-65 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 20-40min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are stood, then quality inspection, packaging, obtain product.
Preferably, dry described in step (3) as drying 6-12h under the conditions of temperature 50-60 DEG C.
Preferably, described in step (3), the particle diameter of medicated powder is 250-300 mesh.
Preferably, stand described in step (5) as standing 18-24h under the conditions of humidity is 50%-60%, temperature 20-25 DEG C.
Its using method is medicine-feeding part for selecting feishu cave, and by Patients with Lung acupoint region skin clean, note applies the Chinese medicine patch of the present invention, and every day is changed once, within one week, is a course for the treatment of, and take medicine 2 courses for the treatment of, heavier patient of the lighter patient of clinical symptoms takes medicine 4 courses for the treatment of；Pungent food greasy, cold and cool is prohibited during treatment.
The pharmacological action of the present invention is:
Herba Ephedrae, warm in nature, acrid in the mouth, micro-hardship, return lung, bladder warp.There is diaphoresis cold expelling, depressed lung-energy dispersing, effect of inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chest breath with cough, edema due to wind pathogen edema.
Ramulus Cinnamomi, warm in nature, acrid in the mouth, sweet, GUIXIN, lung, bladder warp.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, effect of the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Rhizoma Cynanchi Stauntonii, slightly warm in nature, acrid in the mouth, hardship, return lung meridian.There is sending down the abnormal ascending QI, expectorant, effect of cough-relieving.Stop up real for lung qi, cough with copious phlegm, fullness in the chest dyspnea with rapid respiration.
The Rhizoma Pinelliae, warm in nature, acrid in the mouth, return spleen, stomach, lung meridian.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus；Raw with external treatment carbuncle sucutaneous nodule.
Radix Asteris, warm in nature, acrid in the mouth, hardship, return lung meridian.There is expelling phlegm for arresting cough, effect of nourishing the lung to keep the adverse QI downward.Coughing for QI rising in reverse order, expectorant is told unfavorable, chronic cough of deficiency lung, sputum mixed with blood.
Folium Perillae, warm in nature, acrid in the mouth, return lung, spleen channel.There is relieving exterior syndrome and dispelling cold, effect of relieving QI stagnancy in the stomach.For anemofrigid cold, vomiting and nausea of coughing, vomiting during pregnancy, fish Eriocheir sinensis is poisoned.
Rhizoma Belamcandae, bitter in the mouth cold in nature, return lung meridian.There is heat-clearing and toxic substances removing, expectorant, effect of sore-throat relieving.Tie for pyretic toxicity phlegm-fire Tai, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.
Flos Farfarae, warm in nature, acrid in the mouth, micro-hardship.Return lung meridian.There is nourishing the lung to keep the adverse QI downward, effect of relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.
Cacumen Tamaricis, for the delicate branch and leaf of Tamaricaceae Ramulus et Folium Tamaricis, tamarix juniperina Bunge or Tamarix ramosissima.Nature and flavor are sweet, salty, and property is put down.Enter lung, stomach, heart channel.Have dispelling wind, induce sweat, rash, diuresis, effect of removing toxic substances.For treating measles difficult saturating, rubella itching over the body, flu, cough with asthma, rheumatic ostalgia.
Radix Peucedani, cold nature, bitter in the mouth, pungent, return lung meridian.There is lowering the adverse-rising QI to resolve phlegm, dissipate effect of wind heat clearing away.Full for expectorant dyspnea of heat type, cough up phlegm yellow thick, cough due to pathogenic wind-heat's abundant expectoration.
Radix Platycodonis, property is put down, bitter in the mouth, pungent, returns lung meridian.There is lung qi dispersing, sore-throat relieving, eliminate the phlegm, effect of evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, lung abscess vomiting pus.
Radix Paeoniae, property is bitter, be slightly cold, and has and has nourishing the blood and yin, pain relieving hepatoprotective convulsion, the effect eased pain, stimulate the menstrual flow, be used for suffering from abdominal pain, stomach spasm, dizziness, gout, diuresis etc..
Fructus Schisandrae Chinensis, warm in nature, sour in the mouth, sweet.Return lung, the heart, kidney channel.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Glycyrrhizae Preparata, property is flat, sweet in the mouth, GUIXIN, lung, spleen, stomach warp.There is spleen reinforcing stomach function regulating, effect of Yiqi and vein recovery.It is usually used in weakness of the spleen and stomach, tired weak, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Semen Sinapis Albae, warm in nature, acrid in the mouth, enter lung, stomach warp.There is effect of promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.For phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain numbness, tinea pedis, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Fructus Perillae, warm in nature, acrid in the mouth, return lung meridian.There is lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, effect of loosening bowel to relieve constipation.QI rising in reverse order, cough and asthma, dryness of the intestine constipation is stopped up for expectorant.
Semen Raphani, property is put down, acrid in the mouth, sweet, returns lung, spleen, stomach warp.There is the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
The invention has the beneficial effects as follows:
The present invention is directed to pathogenesis etiology and the pathogenesis causing the pathogenic factors of children's cough due to wind and cold to study this disease, use differentiation of tcm thought, with supplementing QI for expelling the pathogenic factors from the body surface, activating QI to eliminate phlegm is primary treatments, use the theoretical medication of tcm prescription " monarch, minister, help, make ", reach effectively to treat the purpose of children's cough due to wind and cold, have specifically following some:
(1) with Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris as monarch drug, based on inducing sweat, to regulate the flow of vital energy as at all, emphasize diaphoresis cold expelling, induce sweat eliminating evil, circulation of qi promoting dissipating blood stasis, its epheday intermedia compatibility Ramulus Cinnamomi, diaphoresis cold expelling is to solve pathogenic factor in the exterior, and a surname sends out lung qi and relievings asthma and cough, and Ramulus Cinnamomi activating QI row water is in order to the change of inner drink, Rhizoma Cynanchi Stauntonii compatibility Radix Asteris and the Rhizoma Pinelliae, Rhizoma Cynanchi Stauntonii energy preventing phlegm from forming and stopping coughing sending down the abnormal ascending QI, Radix Asteris relieving cough and resolving phlegm are relievingd asthma, Rhizoma Pinelliae drying dampness to eliminate phlegm, and five share, and reach the effect having warming the lung for resolving phlegm, relieving cough and asthma；With Rhizoma Belamcandae, Flos Farfarae, Folium Perillae and Cacumen Tamaricis as ministerial drug, wherein Rhizoma Belamcandae, Flos Farfarae can be relievingd asthma by dissipating phlegm and keeping the adverse QI downwards, the pungent temperature of Folium Perillae, return lung spleen channel, Cacumen Tamaricis dispelling wind to relieve the exterior syndrome, and diuresis is detoxified, and four share, can dispelling exopathogens from superficies of the body, again can lung qi dispersing cough-relieving, promoting the circulation of QI to alleviate the stagnation in middle-JIAO；So have phlegm retention, spleen lung deficiency in origin, dissipates by pungent temperature if pure, probably consumption impairing the lung gas, therefore with Radix Peucedani, Radix Platycodonis, Radix Paeoniae and Fructus Schisandrae Chinensis as adjuvant drug, Radix Peucedani, Radix Platycodonis energy relieving cough and resolving phlegm, dispersing and lowering lung-QI, Fructus Schisandrae Chinensis astringing lung-QI and relieving cough, Radix Paeoniae and nutrition blood, four medicines match with the pungent medicine dissipated, one dissipates receipts, both can strengthen the merit of relieving cough and asthma, can restrict again the pungent scattered warm-dryness syndrome of all medicines fraud too；With the double medicine that makes of Radix Glycyrrhizae Preparata, Radix Glycyrrhizae QI invigorating regulating the spleen and stomach, hold concurrently and all medicines, both can QI invigorating and in, can be in harmonious proportion again pungent dissipate, the medicine of acid receipts.
(2) raw material is prepared as Chinese medicine patch by the Chinese medicine patch of the present invention, during use, surface envelope paper is thrown off, tablet is directly touched feishu cave, back, pharmaceutical compositions can play a role via the point skin of children's, by infiltrating through skin, interior transmission from one channel to another network, internal organs, it then follows the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of traditional Chinese medical science monarch and effect of Chinese medicine, cure mainly with return through principle, give full play to coordinate mutually between various medicine for usefulness；FEIYU acupoint is the acupuncture points on the human body at meridian of Foot-TAI YANG back, because of its planted agent's lungs, be lung qi transfer, in place of infusion, for treating the important acupuncture points on the human body of pneumonopathy.The present invention is attached to feishu cave, medicine in feishu cave by skin absorption, escape through and on a series of diseases of cough due to wind and cold are treated, play QI and blood regulating, the meridian dredging, effect that cold expelling is wet, and then play the effect of the treatment cough of medicine, it is achieved inner disease outer treat.
(3) section Example of the present invention adds Semen Sinapis Albae, Fructus Perillae and Semen Raphani and Rhizoma Belamcandae, Flos Farfarae, Folium Perillae, Cacumen Tamaricis are worked in coordination with as ministerial drug, wherein Semen Sinapis Albae warming the lung for resolving phlegm, eliminating stagnation promoting the circulation of QI；Fructus Perillae lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, Semen Raphani lowering the adverse-rising QI to resolve phlegm, dyspepsia and intestinal stasis relieving, Semen Sinapis Albae compatibility Fructus Perillae, Semen Raphani three medicine 5 are used, there are warming the lung for resolving phlegm, lowering the adverse-rising QI to subdue asthma, effect of relieving dyspepsia removing food stagnancy, Semen Raphani has digestive function simultaneously, seven work in coordination with 5 use, can improve, while treatment children's's expectorant stops up the disease of the cough dyspnea of QI rising in reverse order, abundant expectoration uncomfortable in chest, the body digestive function weakness that children's causes because of cough, the disease that lack of appetite difficulty disappears, improve the immunologic function of body, accelerate the process that cough is cured.
(4) preparation method of the present invention is simple, uses slow fire boiling each taste raw material of Chinese medicine so that the effective ingredient in raw material of Chinese medicine is at utmost leached, and obtains thick paste；Then oven drying at low temperature in using, stir-fry medicinal residues, grind to form medicated powder, finally thick paste and medicated powder are prepared Chinese medicine patch jointly, the comprehensive effective ingredient remaining raw material of Chinese medicine of Chinese medicine patch of preparation, collaborative hydrophilic Chinese medicine patch substrate glycerol and sodium polyacrylate, the effective ingredient making Chinese medicine patch can farthest be absorbed by the patient, by the skin absorption of meridian point, stimulate teleneuron, by reflection, expansion blood vessel, promote local blood circulation, improve surrounding tissue nutrition, relieving cough and resolving phlegm is relievingd asthma, improve immunity of organisms, it is thus able to realize children's cough due to wind and cold effectively.
Detailed description of the invention
Embodiment 1
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: 10 parts of Herba Ephedrae, Ramulus Cinnamomi 20 parts, Rhizoma Cynanchi Stauntonii 7 parts, the Rhizoma Pinelliae 15 parts, Radix Asteris 6 parts, Folium Perillae 16 parts, Rhizoma Belamcandae 6 parts, Flos Farfarae 13 parts, Cacumen Tamaricis 3 parts, Radix Peucedani 8 parts, Radix Platycodonis 4 parts, Radix Paeoniae 5 parts, Fructus Schisandrae Chinensis 1 part, Radix Glycyrrhizae Preparata 10 parts, glycerol 40 parts and sodium polyacrylate 1 part.
Its preparation method, comprises the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata by formula and mix, add the water of 15 times of medical material gross weights, after soaking 60min, decoct 2 hours, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.36 relative to water；The filtering residue obtained in step (2) is dried under the conditions of power temperature 50 DEG C 6h, and being then ground to particle diameter is 250 mesh powder, and under the conditions of 65 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 20min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are 50% in humidity, stand 18h, then quality inspection, packaging under the conditions of temperature 25 DEG C, obtains product.
Embodiment 2
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: 20 parts of Herba Ephedrae, Ramulus Cinnamomi 10 parts, Rhizoma Cynanchi Stauntonii 15 parts, the Rhizoma Pinelliae 8 parts, Radix Asteris 9 parts, Folium Perillae 10 parts, Rhizoma Belamcandae 12 parts, Flos Farfarae 5 parts, Cacumen Tamaricis 7 parts, Radix Peucedani 4 parts, Radix Platycodonis 8 parts, Radix Paeoniae 1 part, Fructus Schisandrae Chinensis 5 parts, Radix Glycyrrhizae Preparata 20 parts, glycerol 60 parts and sodium polyacrylate 5 parts.
Its preparation method, comprises the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata by formula and mix, add the water of 20 times of medical material gross weights, after soaking 30min, decoct 4 hours, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.40 relative to water；The filtering residue obtained in step (2) is dried under the conditions of power is temperature 60 C 12h, and being then ground to particle diameter is 300 mesh powder, and under the conditions of 60 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 40min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are 60% in humidity, stand 24h, then quality inspection, packaging under the conditions of temperature 20 DEG C, obtains product.
Embodiment 3
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: 17 parts of Herba Ephedrae, Ramulus Cinnamomi 13 parts, Rhizoma Cynanchi Stauntonii 12 parts, the Rhizoma Pinelliae 11 parts, Radix Asteris 7 parts, Folium Perillae 14 parts, Rhizoma Belamcandae 8 parts, Flos Farfarae 10 parts, Cacumen Tamaricis 4 parts, Radix Peucedani 7 parts, Radix Platycodonis 5 parts, Radix Paeoniae 4 parts, Fructus Schisandrae Chinensis 2 parts, Radix Glycyrrhizae Preparata 17 parts, glycerol 55 parts and sodium polyacrylate 2 parts.
Its preparation method, comprises the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata by formula and mix, add the water of 18 times of medical material gross weights, after soaking 40min, decoct 3 hours, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.37 relative to water；The filtering residue obtained in step (2) is dried under the conditions of power temperature 52 DEG C 10h, and being then ground to particle diameter is 280 mesh powder, and under the conditions of 60 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 35min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are 55% in humidity, stand 20h, then quality inspection, packaging under the conditions of temperature 24 DEG C, obtains product.
Embodiment 4
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: 13 parts of Herba Ephedrae, Ramulus Cinnamomi 17 parts, Rhizoma Cynanchi Stauntonii 10 parts, the Rhizoma Pinelliae 13 parts, Radix Asteris 8 parts, Folium Perillae 12 parts, Rhizoma Belamcandae 10 parts, Flos Farfarae 8 parts, Cacumen Tamaricis 6 parts, Radix Peucedani 5 parts, Radix Platycodonis 7 parts, Radix Paeoniae 2 parts, Fructus Schisandrae Chinensis 4 parts, Radix Glycyrrhizae Preparata 13 parts, glycerol 45 parts and sodium polyacrylate 4 parts.
Its preparation method, comprises the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata by formula and mix, add the water of 19 times of medical material gross weights, after soaking 45min, decoct 2.5 hours, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.39 relative to water；The filtering residue obtained in step (2) is dried under the conditions of power temperature 58 DEG C 9h, and being then ground to particle diameter is 260 mesh powder, and under the conditions of 62 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 28min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are 58% in humidity, stand 22h, then quality inspection, packaging under the conditions of temperature 22 DEG C, obtains product.
Embodiment 5
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: 15 parts of Herba Ephedrae, Ramulus Cinnamomi 15 parts, Rhizoma Cynanchi Stauntonii 11 parts, the Rhizoma Pinelliae 12 parts, Radix Asteris 9 parts, Folium Perillae 13 parts, Rhizoma Belamcandae 9 parts, Flos Farfarae 9 parts, Cacumen Tamaricis 5 parts, Radix Peucedani 6 parts, Radix Platycodonis 6 parts, Radix Paeoniae 3 parts, Fructus Schisandrae Chinensis 3 parts, Radix Glycyrrhizae Preparata 15 parts, glycerol 50 parts and sodium polyacrylate 3 parts.
Its preparation method, comprises the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata by formula and mix, add the water of 17 times of medical material gross weights, after soaking 45min, decoct 3 hours, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.38 relative to water；The filtering residue obtained in step (2) is dried under the conditions of power temperature 55 DEG C 8h, and being then ground to particle diameter is 280 mesh powder, and under the conditions of 63 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 30min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are 55% in humidity, stand 21h, then quality inspection, packaging under the conditions of temperature 23 DEG C, obtains product.
Embodiment 6
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: 14 parts of Herba Ephedrae, Ramulus Cinnamomi 12 parts, Rhizoma Cynanchi Stauntonii 8 parts, the Rhizoma Pinelliae 10 parts, Radix Asteris 7 parts, Folium Perillae 15 parts, Rhizoma Belamcandae 11 parts, Flos Farfarae 7 parts, Cacumen Tamaricis 6 parts, Radix Peucedani 5 parts, Radix Platycodonis 7 parts, Radix Paeoniae 4 parts, Fructus Schisandrae Chinensis 3 parts, Radix Glycyrrhizae Preparata 11 parts, glycerol 45 parts and sodium polyacrylate 4 parts.
Its preparation method, comprises the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata by formula and mix, add the water of 16 times of medical material gross weights, after soaking 50min, decoct 2 hours, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.39 relative to water；The filtering residue obtained in step (2) is dried under the conditions of power temperature 53 DEG C 11h, and being then ground to particle diameter is 290 mesh powder, and under the conditions of 64 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 35min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are 58% in humidity, stand 19h, then quality inspection, packaging under the conditions of temperature 21 DEG C, obtains product.
Embodiment 7
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: 18 parts of Herba Ephedrae, Ramulus Cinnamomi 14 parts, Rhizoma Cynanchi Stauntonii 9 parts, the Rhizoma Pinelliae 14 parts, Radix Asteris 8 parts, Folium Perillae 11 parts, Rhizoma Belamcandae 7 parts, Flos Farfarae 12 parts, Cacumen Tamaricis 4 parts, Radix Peucedani 8 parts, Radix Platycodonis 6 parts, Radix Paeoniae 2 parts, Fructus Schisandrae Chinensis 4 parts, Radix Glycyrrhizae Preparata 19 parts, glycerol 60 parts and sodium polyacrylate 2 parts.
Its preparation method is same as in Example 2.
Embodiment 8
A kind of Chinese medicine patch treating children's cough due to wind and cold, including the raw material of following weight portion: 12 parts of Herba Ephedrae, Ramulus Cinnamomi 19 parts, Rhizoma Cynanchi Stauntonii 13 parts, the Rhizoma Pinelliae 9 parts, Radix Asteris 9 parts, Semen Sinapis Albae 8 parts, Fructus Perillae 7 parts, Semen Raphani 6 parts, Folium Perillae 14 parts, Rhizoma Belamcandae 8 parts, Flos Farfarae 11 parts, Cacumen Tamaricis 5 parts, Radix Peucedani 7 parts, Radix Platycodonis 4 parts, Radix Paeoniae 3 parts, Fructus Schisandrae Chinensis 1 part, Radix Glycyrrhizae Preparata 16 parts, glycerol 50 parts and sodium polyacrylate 3 parts.
Its preparation method, comprises the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Semen Sinapis Albae, Fructus Perillae, Semen Raphani, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata by formula and mix, add the water of 17 times of medical material gross weights, after soaking 45min, decoct 3 hours, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.38 relative to water；The filtering residue obtained in step (2) is dried under the conditions of power temperature 55 DEG C 8h, and being then ground to particle diameter is 280 mesh powder, and under the conditions of 63 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 30min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are 55% in humidity, stand 21h, then quality inspection, packaging under the conditions of temperature 23 DEG C, obtains product.
Clinical trial
Cold in the exterior and fluid-retention in the interior is demonstrate,proved.Fever with aversion to cold, head-body-pain, lossless, to breath with cough, sputum is the dilutest and measures many, the feeling of stuffiness in chest, or retches, or phlegm retention is breathed with cough, and must not put down sleeping, or health pain weight, head extremity edema, white and slippery fur, floating pulse.
One, physical data
From in March, 2015 in March, 2016, treating children's cough due to wind and cold patient 102 example, the age is between 6 months-6 years old.
Two, diagnostic criteria
Cough due to wind and cold's diagnostic criteria: breath with cough, thin color of coughing up phlegm is white, aversion to cold, or has heating, lossless.Thin white fur of tongue, floating and tense pulse.
Three, efficacy assessment standard
(1) cure: cough and clinical sign disappear, and drug withdrawal is not recurred for more than two weeks.
(2) effective: cough alleviates, amount of expectoration reduces.
(4) invalid: symptom is not improved.
Four, therapeutic scheme
Selecting feishu cave is medicine-feeding part, and by Patients with Lung acupoint region skin clean, note applies the Chinese medicine patch of the present invention, and every day is changed once, within one week, is a course for the treatment of, totally two courses for the treatment of.
Patient sticks the Chinese medicine patch that the embodiment of the present invention 1～8 prepares at random, concrete grammar is medicine-feeding part for selecting feishu cave, by Patients with Lung acupoint region skin clean, note applies the Chinese medicine patch of the present invention, every day is changed once, within one week, being a course for the treatment of, take medicine 2 courses for the treatment of, heavier patient of the lighter patient of clinical symptoms takes medicine 4 courses for the treatment of；Pungent food greasy, cold and cool is prohibited during treatment.
Five, statistical result
Cure 97 examples, effective 3 examples, invalid 2 examples, total effective rate 98.04%.
Model case
Case 1: poplar, man, 2 years old, Xichuan County, henan Province people.Weekend man's long band its travel outdoors after in succession occur nasal obstruction watery nasal discharge, generate heat, symptom of cough, in March, 2015, the head of a family takes infant and comes here and go to a doctor, and inquiring finds that infant is breathed with cough, cough up phlegm thin color in vain, aversion to cold.Thin white fur of tongue, floating and tense pulse.Through auscultation of lung: patient both sides pulmonary respiratory harshness；X Chest X-rays inspection display increased bronchovascular shadows.After sticking 2 courses for the treatment of of medicine of the present invention, clinical symptom disappearance.After drug withdrawal surrounding, Effect of follow-up visit by telephone did not recur.
Case 2: Lee, female, 1 years old, people from Zhenping, Henan.Weather turns suddenly cool, infant occur nasal obstruction watery nasal discharge, generate heat, symptom of cough, in JIUYUE, 2015, the head of a family takes infant and comes here and go to a doctor, and inquiring finds that infant is breathed with cough, cough up phlegm thin color in vain, aversion to cold, or have heating, lossless.Through auscultation of lung: patient both sides pulmonary respiratory harshness；X Chest X-rays inspection display lung marking substantially increases slightly.After sticking 4 courses for the treatment of of medicine of the present invention, clinical symptom disappearance.After drug withdrawal surrounding, Effect of follow-up visit by telephone did not recur.
Case 3, week certain, female, 8 months, Earthquake of Anyang station in Henan people.Father and mother are in after having a bath to it, infant occur nasal obstruction watery nasal discharge, generate heat, symptom of cough, in November, 2015, the head of a family takes infant and comes here and go to a doctor, and inquiring finds that infant is breathed with cough, cough up phlegm thin color in vain, aversion to cold, or have heating, lossless, floating and tense pulse.Through auscultation of lung: patient both sides pulmonary respiratory harshness；X Chest X-rays inspection display increased bronchovascular shadows.After sticking 2 courses for the treatment of of medicine of the present invention, clinical symptom disappearance.After drug withdrawal surrounding, Effect of follow-up visit by telephone did not recur.
Case 4: gold certain, man, 5 years old, Henan Xixia Mine people.After kindergarten leaves school, the head of a family finds infant heating, cough symptom, in March, 2016, and the head of a family takes infant and comes here and go to a doctor, and inquiring finds that infant is breathed with cough, and thin color of coughing up phlegm is white, aversion to cold, or has heating, lossless, floating and tense pulse.Through auscultation of lung: patient both sides pulmonary respiratory harshness；X Chest X-rays inspection display increased bronchovascular shadows.After sticking 4 courses for the treatment of of medicine of the present invention, clinical symptom disappearance.After drug withdrawal surrounding, Effect of follow-up visit by telephone did not recur.
Finally illustrate is, above example is only in order to illustrate technical scheme and unrestricted, other amendment or equivalents that technical scheme is made by those of ordinary skill in the art, without departing from the spirit and scope of technical solution of the present invention, all should contain in the middle of scope of the presently claimed invention.
Claims (7)
1. the Chinese medicine patch treating children's cough due to wind and cold, it is characterized in that, including the raw material of following weight portion: Herba Ephedrae 10-20 part, Ramulus Cinnamomi 10-20 part, Rhizoma Cynanchi Stauntonii 7-15 part, Rhizoma Pinelliae 8-15 part, Radix Asteris 6-9 part, Folium Perillae 10-16 part, Rhizoma Belamcandae 6-12 part, Flos Farfarae 5-13 part, Cacumen Tamaricis 3-7 part, Radix Peucedani 4-8 part, Radix Platycodonis 4-8 part, Radix Paeoniae 1-5 part, Fructus Schisandrae Chinensis 1-5 part, Radix Glycyrrhizae Preparata 10-20 part, glycerol 40-60 part and sodium polyacrylate 1-5 part.
The Chinese medicine patch for the treatment of children's cough due to wind and cold the most according to claim 1, it is characterized in that, including the raw material of following weight portion: Herba Ephedrae 13-17 part, Ramulus Cinnamomi 13-17 part, Rhizoma Cynanchi Stauntonii 10-12 part, Rhizoma Pinelliae 11-13 part, Radix Asteris 7-8 part, Folium Perillae 12-14 part, Rhizoma Belamcandae 8-10 part, Flos Farfarae 8-10 part, Cacumen Tamaricis 4-6 part, Radix Peucedani 5-7 part, Radix Platycodonis 5-7 part, Radix Paeoniae 2-4 part, Fructus Schisandrae Chinensis 2-4 part, Radix Glycyrrhizae Preparata 13-17 part, glycerol 45-55 part and sodium polyacrylate 2-4 part.
The Chinese medicine patch for the treatment of children's cough due to wind and cold the most according to claim 2, it is characterized in that, including the raw material of following weight portion: 15 parts of Herba Ephedrae, Ramulus Cinnamomi 15 parts, Rhizoma Cynanchi Stauntonii 11 parts, the Rhizoma Pinelliae 12 parts, Radix Asteris 9 parts, Folium Perillae 13 parts, Rhizoma Belamcandae 9 parts, Flos Farfarae 9 parts, Cacumen Tamaricis 5 parts, Radix Peucedani 6 parts, Radix Platycodonis 6 parts, Radix Paeoniae 3 parts, Fructus Schisandrae Chinensis 3 parts, Radix Glycyrrhizae Preparata 15 parts, glycerol 50 parts and sodium polyacrylate 3 parts.
4. the preparation method of the Chinese medicine patch of the treatment children's cough due to wind and cold as described in any one of claim 1-3, it is characterised in that comprise the following steps:
(1) raw material of Chinese medicine is standby after removing the removal of impurity, cleaning-drying；
(2) weigh Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, the Rhizoma Pinelliae, Radix Asteris, Folium Perillae, Rhizoma Belamcandae, Flos Farfarae, Cacumen Tamaricis, Radix Peucedani, Radix Platycodonis, Radix Paeoniae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata and mix, add the water of 15-20 times of medical material gross weight, after soaking 30-60min, decoct 2-4 hour, filter, obtain filtrate and filtering residue, standby；
(3) the filtrate slow fire heating that will obtain in step (2), is concentrated to give the thick paste that density is 1.36-1.40 relative to water；Being dried by the filtering residue obtained in step (2), be then ground to powder, under the conditions of 60-65 DEG C, little fire is fried to brown color, obtains medicated powder；
(4) thick paste, the medicated powder that step (3) are obtained mix, and are added thereto to glycerol and sodium polyacrylate, and 20-40min is to mix homogeneously in stirring, obtains medicine carrying mastic；
(5) it is transferred on plaster coater be coated with, cut by the medicine carrying mastic that step (4) obtains, obtains semi-finished product；Semi-finished product are stood, then quality inspection, packaging, obtain product.
The preparation method of the Chinese medicine patch for the treatment of children's cough due to wind and cold the most according to claim 4, it is characterised in that dry 6-12h under the conditions of drying temperature 50-60 DEG C described in step (3).
The preparation method of the Chinese medicine patch for the treatment of children's cough due to wind and cold the most according to claim 4, it is characterised in that described in step (3), the particle diameter of medicated powder is 250-300 mesh.
The preparation method of the Chinese medicine patch for the treatment of children's cough due to wind and cold the most according to claim 4, it is characterised in that stand described in step (5) as standing 18-24h under the conditions of humidity is 50%-60%, temperature 20-25 DEG C.
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