CN106389624A - Traditional Chinese medicine unguent for treating chilblains and preparation method of traditional Chinese medicine unguent for treating chilblains - Google Patents
Traditional Chinese medicine unguent for treating chilblains and preparation method of traditional Chinese medicine unguent for treating chilblains Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
本发明公开一种治疗冻疮的中药膏及其制备方法,包括以下重量份的原料:樟脑3‑5份、艾草20‑40份、花椒10‑30份、冬瓜皮5‑15份、桂皮5‑15份、蜂蜜20‑30份、蛋黄40‑60份、当归10‑20份、松节油10‑20份。本发明各原料用量恰当,配伍合理,解除了冻疮的痒痛症状,而且具有润肤效果;原料种类少,治疗冻疮总有效率达97%,治愈率达93%,治疗效果显著。The invention discloses a traditional Chinese medicine ointment for treating frostbite and a preparation method thereof, which comprises the following raw materials in parts by weight: 3-5 parts of camphor, 20-40 parts of wormwood, 10-30 parts of Chinese prickly ash, 5-15 parts of wax gourd skin, and 5 parts of cassia bark ‑15 parts, honey 20‑30 parts, egg yolk 40‑60 parts, angelica 10‑20 parts, turpentine 10‑20 parts. The dosage of each raw material in the invention is reasonable, the compatibility is reasonable, the itching and pain symptoms of chilblain are relieved, and the skin moisturizing effect is achieved; the raw materials are few in type, the total effective rate of treating chilblain is 97%, the cure rate is 93%, and the treatment effect is remarkable.
Description
技术领域technical field
本发明属于皮肤病治疗防治技术领域,尤其涉及一种治疗冻疮的中药膏及其制备方法。The invention belongs to the technical field of skin disease treatment and prevention, and in particular relates to a traditional Chinese medicine ointment for treating frostbite and a preparation method thereof.
背景技术Background technique
冻疮是机体受到寒冷侵袭后发生在末梢部位局限性红斑炎症性疾病,常见损害为局限性瘀血性暗紫色隆起的水肿性红斑,境界不清,严重者可发生水疱,破裂后形成糜烂或溃疡,愈后有色素沉着或萎缩性瘢痕,痒且受热后加剧,症状常发生在暴漏在空气中的软组织,例如耳垂,特别是接触冰冷外界物质的关节处的软组织,例如右手手指关节处。冻疮为临床上冬季的常见病、多发病, 瘙痒疼痛给患者带来痛苦,市面上现有的治疗冻疮的药物虽有一定疗效,但起效较慢,治疗效果差,而且对皮肤容易产生过敏。Frostbite is a localized erythematous inflammatory disease that occurs at the extremities of the body after being attacked by cold. The common damage is localized stagnant dark purple raised edematous erythema with unclear borders. In severe cases, blisters may occur, which rupture and form erosions or ulcers. Hyperpigmentation or atrophic scarring behind, itching and exacerbated by heat, symptoms often occur in soft tissues exposed to air, such as earlobes, especially in joints that are exposed to cold foreign substances, such as the knuckles of the fingers of the right hand. Frostbite is a common and frequently-occurring disease in clinical practice in winter, and itching and pain bring pain to patients. Although the existing medicines for frostbite on the market have certain curative effects, they take effect slowly, have poor therapeutic effects, and are prone to skin allergies .
申请号CN201510970909.4公开了一种治疗冻疮药膏,所述药物以重量配比的物质制成:党参8-15g,黄芪10-20g,附子3-8g,桂枝8-15g,当归8-15g,丹参6-10g,陈皮5-8g,干姜5-8g,炙甘草5-10g,白蔹10-15g,肉桂4-8g,红花油4-8g,姜油4-8g,薄荷3-5g,凡士林15-25g,甘油10-15g。该结构的不足之处在于:配料多,成本高。Application number CN201510970909.4 discloses an ointment for treating chilblain. The medicine is made of substances with a weight ratio: Codonopsis 8-15g, Radix Astragali 10-20g, Aconite 3-8g, Guizhi 8-15g, Angelica 8-15g , Danshen 6-10g, tangerine peel 5-8g, dried ginger 5-8g, roasted licorice 5-10g, white pomegranate 10-15g, cinnamon 4-8g, safflower oil 4-8g, ginger oil 4-8g, mint 3- 5g, vaseline 15-25g, glycerin 10-15g. The weak point of this structure is: batching is many, and cost is high.
申请号CN201410475741.5公开一种治疗冻疮外敷药膏,包括如下重量含量的成分:红花10-20份,桂枝15-20份,荆芥10-20份,花椒20-30份,辣椒1-5份,良姜5-10份,郁金2-3份,凡士林20-40份。该发明的不足之处在于:针对已经发生溃烂的冻疮症状,将含有辣椒的药膏涂抹在伤口上,存在不适感。Application number CN201410475741.5 discloses a kind of external application ointment for treating frostbite, which includes the following components by weight: 10-20 parts of safflower, 15-20 parts of cassia twig, 10-20 parts of nepeta, 20-30 parts of pepper, 1- 5 parts, 5-10 parts of ginger, 2-3 parts of turmeric, 20-40 parts of Vaseline. The weak point of this invention is: for the chilblain symptom that festering has taken place, the ointment that contains capsicum is smeared on the wound, and there is sense of discomfort.
发明内容Contents of the invention
有鉴于此,本发明的目的是针对现有技术的不足,提供一种治疗冻疮的中药膏及其制备方法,本发明各原料用量恰当,配伍合理,解除了冻疮的痒痛症状,而且具有润肤效果;原料种类少,治疗冻疮总有效率达97%,治愈率达93%,治疗效果显著。In view of this, the purpose of the present invention is to address the deficiencies in the prior art, to provide a kind of Chinese medicine ointment for the treatment of chilblain and its preparation method. skin effect; there are few types of raw materials, the total effective rate of treating frostbite is 97%, the cure rate is 93%, and the treatment effect is remarkable.
为达到上述目的,本发明采用以下技术方案:To achieve the above object, the present invention adopts the following technical solutions:
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑3-5份、艾草20-40份、花椒10-30份、冬瓜皮5-15份、桂皮5-15份、蜂蜜20-30份、蛋黄40-60份、当归10-20份、松节油10-20份。A traditional Chinese medicine ointment for treating frostbite, comprising the following raw materials in parts by weight: 3-5 parts of camphor, 20-40 parts of wormwood, 10-30 parts of Chinese prickly ash, 5-15 parts of wax gourd skin, 5-15 parts of cinnamon bark, 20-20 parts of honey 30 parts, egg yolk 40-60 parts, angelica 10-20 parts, turpentine 10-20 parts.
进一步的,樟脑为4份、艾草30份、花椒20份、冬瓜皮10份、桂皮10份、蜂蜜25份、蛋黄50份、当归15份、松节油15份。Further, 4 parts of camphor, 30 parts of wormwood, 20 parts of Chinese prickly ash, 10 parts of wax gourd skin, 10 parts of cinnamon bark, 25 parts of honey, 50 parts of egg yolk, 15 parts of angelica, and 15 parts of turpentine.
进一步的,艾草为祁艾的叶。Further, wormwood is the leaf of Qi AI.
一种治疗冻疮的中药膏的制备方法,包括以下步骤:A preparation method for treating chilblain Chinese medicine ointment, comprising the following steps:
(1)将樟脑、艾草、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,取清洗后的鸡蛋的蛋黄备用;(1) Remove impurities from camphor, mugwort, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry them for later use, and take the egg yolk after washing for later use;
(2)称取樟脑、当归、艾草、花椒、冬瓜皮、桂皮,加入15-20倍药材总重量的水,浸泡30-60min后,煎煮2-4小时,过滤,得到滤液和滤渣,备用;(2) Weigh camphor, angelica, mugwort, Chinese prickly ash, winter melon skin, and cinnamon bark, add water 15-20 times the total weight of medicinal materials, soak for 30-60 minutes, decoct for 2-4 hours, filter to obtain filtrate and filter residue, spare;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.36-1.40的稠膏;将步骤(2)中得到的滤渣烘干,然后研磨成粉末,在60-65℃条件下烘干,再使用小火炒至棕黄色,得到药粉;(3) Heat the filtrate obtained in step (2), add honey to the filtrate, and concentrate to obtain a thick paste with a density of 1.36-1.40 relative to water; dry the filter residue obtained in step (2), and then Grind into powder, dry at 60-65°C, and stir-fry over low heat until brown-yellow to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并向其中加入蛋黄和松节油,搅拌20-40min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), add egg yolk and turpentine, and stir for 20-40 minutes until uniformly mixed to obtain a traditional Chinese medicine ointment.
进一步的,步骤(1)中将鸡蛋清洗后进行消毒,破壳后使用一次性注射器抽取蛋黄备用。Further, in step (1), the eggs are washed and then sterilized, and the egg yolks are extracted with a disposable syringe after breaking the shells for later use.
进一步的,步骤(3)中烘干时间为6-12h。Further, the drying time in step (3) is 6-12 hours.
进一步的,步骤(3)中所述药粉的粒径为250-300目。Further, the particle size of the medicinal powder in step (3) is 250-300 mesh.
本发明的药理作用是:Pharmacological action of the present invention is:
樟脑:性热,味辛,归心、脾经;内服:开窍辟秽,外用:除湿杀虫,温散、止痒、镇痛。本品辛热燥烈、有毒,外用既能除湿,又能攻毒杀虫,收消肿、止痒之效。本品辛热得散,利滞气、消肿止痛;樟脑涂于皮肤有临床上用樟脑擦剂有镇痛、止痒作用。Camphor: hot in nature, pungent in the mouth, heart-guiding, spleen meridian; Oral administration: resuscitating and warding off foulness, external application: dehumidifying and killing parasites, warming and dispersing, relieving itching, analgesia. This product is pungent, hot, dry and poisonous. External use can not only dehumidify, but also attack poison and kill insects, reduce swelling and relieve itching. This product dissipates pungent heat, sharpens qi stagnation, reduces swelling and relieves pain; camphor is applied to the skin and has clinically used camphor liniment to relieve pain and relieve itching.
艾草:味苦、性温,入脾、肝、肾经;具有回阳、理气血、逐湿寒、止血安胎等功效;具有调经止血﹑安胎止崩﹑散寒除湿之效,而且艾叶具有抗菌及抗病毒作用。Wormwood: bitter in taste and warm in nature, it enters the spleen, liver, and kidney meridians; it has the effects of restoring yang, regulating qi and blood, expelling dampness and cold, stopping bleeding and preventing miscarriage; And Artemisia argyi has antibacterial and antiviral effects.
花椒:味辛,性温,归脾、胃、肾经;具有温中行气、散寒除湿、解郁结、消宿食、通三焦、温脾胃、补右肾命门、杀蛔虫、止泄泻功效。Zanthoxylum bungeanum: pungent in taste, warm in nature, returns to the spleen, stomach, and kidney meridians; it has the functions of warming the middle and promoting qi, dispelling cold and dehumidification, relieving stagnation, eliminating stagnation, clearing the triple burner, warming the spleen and stomach, nourishing the right kidney and vital gate, killing roundworms, and stopping diarrhea effect.
冬瓜皮:味甘,性微寒,入脾、肠、经;具有去湿追风、补脾泻火之功效。Winter melon skin: sweet in taste, slightly cold in nature, enters the spleen, intestines, and meridians; it has the effects of removing dampness and chasing wind, nourishing the spleen and purging fire.
桂皮:味辛,性温,入心、肝、脾、肾四经;具有温脾胃、暖肝肾、祛寒止痛、散瘀消肿之功效。用于脘腹冷痛、呕吐泄泻、腰膝酸冷、寒疝腹痛、寒湿痹痛、瘀滞痛经、血痢、肠风、跌打肿痛。Cinnamon bark: pungent in taste, warm in nature, enters the heart, liver, spleen, and kidney meridians; it has the effects of warming the spleen and stomach, warming the liver and kidney, dispelling cold and relieving pain, dispelling blood stasis and reducing swelling. Used for cold and pain in the abdomen, vomiting and diarrhea, soreness and coldness of the waist and knees, abdominal pain due to cold colic, arthralgia due to cold and dampness, dysmenorrhea due to stagnation of blood, bloody dysentery, intestinal wind, swelling and pain from falls.
蜂蜜:味甘,性平,归肺、脾、大肠经;具有补中,润燥,止痛,解毒;用于脘腹虚痛,肺燥干咳,肠燥便秘;外治疮疡不敛,水火烫伤。Honey: sweet in taste, flat in nature, returns to the lung, spleen, and large intestine meridian; has the functions of nourishing the middle, moistening dryness, relieving pain, and detoxifying; used for abdominal pain, dry cough due to dryness of the lung, and constipation due to dryness of the intestine; scald.
蛋黄:富含脂溶性维生素,单不饱和脂肪酸,磷,铁等微量元素,具有滋润肌肤的作用,可使肌肤细腻有光泽,尤其适合干性肌肤以及冬天或特别干燥的地区。Egg yolk: Rich in fat-soluble vitamins, monounsaturated fatty acids, phosphorus, iron and other trace elements, it can moisturize the skin and make the skin delicate and shiny, especially suitable for dry skin and winter or particularly dry areas.
当归:味甘,性温,归肝、心、脾经;具有补血、活血、调经止痛、润燥滑肠之功效。可用于主血虚诸证、月经不调、经闭、痛经、症瘕结聚、崩漏、虚寒腹痛、痿痹、肌肤麻木、肠燥便难、赤痢后重、痈疽疮疡、跌扑损伤。Angelica: sweet in taste, warm in nature, returns to the liver, heart, and spleen meridians; has the effects of nourishing blood, promoting blood circulation, regulating menstruation and relieving pain, moistening dryness and smoothing intestines. It can be used for all syndromes of blood deficiency, irregular menstruation, amenorrhea, dysmenorrhea, lumps and lumps, metrorrhagia, abdominal pain due to deficiency and cold, impotence, numbness of the skin, dryness of the intestine, difficulty in defecation, heavy dysentery, carbuncle sores, tumbling damage.
松节油:具有增进局部血液循环,缓解肿胀和轻微止痛作用;用于减轻肌肉痛、关节痛、神经痛以及扭伤。Turpentine: It can improve local blood circulation, relieve swelling and slightly relieve pain; it can be used to relieve muscle pain, joint pain, neuralgia and sprains.
本发明的有益效果是:The beneficial effects of the present invention are:
1.本发明中药制剂治疗冻疮,根据其病因及临床发病特点,以祛湿、消肿止痒为治疗方法进行组方用药,以樟脑、艾草、花椒三种中药为君药,樟脑涂于皮肤具有除湿、止痒、镇痛功效,艾草和花椒具有理气血、逐湿寒的作用;另外,本发明中药制剂使用冬瓜皮、桂皮辅助,进一步改善患者症状皮肤肿胀、皴裂的现象,诸药合用,共为臣药;此外,当归具有疏血活血功效,有效提高君药的药效并且增强君药的药效时间,而且当归全草具有芳香的特点对樟脑的刺激性气味进行有效调理,防止涂覆过程中造成气味不适感,为佐药;松节油作为使药增进症状处的血液循环,而且松节油具有挥发性有利于储药直达病灶,特别是针对关节处的冻疮,松节油还有利于改善风湿性关节炎、抗菌的效果。1. Chinese medicine preparation of the present invention treats chilblain, according to its cause of disease and clinical onset characteristics, carries out prescription medication with dampness-dispelling, detumescence and antipruritic for the treatment method, three kinds of Chinese medicines with camphor, wormwood, Zanthoxylum bungeanum are monarch drug, and camphor is applied to The skin has dehumidification, antipruritic and analgesic effects, and wormwood and Zanthoxylum bungeanum have the functions of regulating qi and blood and expelling dampness and cold; in addition, the traditional Chinese medicine preparation of the present invention uses wax gourd peel and cinnamon to further improve the phenomenon of skin swelling and cracking in patients with symptoms , all medicines are used in combination, and they are ministerial medicines; in addition, Angelica sinensis has the effect of dispersing blood and promoting blood circulation, effectively improving the efficacy of monarch medicine and enhancing the efficacy time of monarch medicine, and the whole plant of Angelica sinensis has the characteristics of fragrance, which can relieve the pungent smell of camphor. Effective conditioning, preventing odor discomfort during the coating process, as an adjuvant drug; turpentine is used as a drug to improve blood circulation at the symptom site, and turpentine is volatile, which is conducive to storing medicine directly to the lesion, especially for frostbite at the joints. Helps improve rheumatoid arthritis and antibacterial effects.
另外,本发明使用蜂蜜、蛋黄为辅料,蜂蜜和蛋黄含有大量能被人体吸收的氨基酸、酶、激素、维生素和糖,具有温润皮肤和滋养皮肤的功效,防止止痒消肿后表层皮肤出现褶皱、起皮的现象,有效提高本发明的润肤效果。In addition, the present invention uses honey and egg yolk as auxiliary materials. Honey and egg yolk contain a large amount of amino acids, enzymes, hormones, vitamins and sugars that can be absorbed by the human body. They have the effect of warming and nourishing the skin and prevent wrinkles on the surface skin after relieving itching and reducing swelling. , peeling phenomenon, effectively improve the moisturizing effect of the present invention.
综上,本发明公开的治疗冻疮的中药膏,多种原料之间相互支持、相互协同,使药效直达病症处并实现内外兼治,缩短治疗周期、提高治疗效果。To sum up, in the traditional Chinese medicine ointment for treating frostbite disclosed by the present invention, various raw materials support each other and cooperate with each other, so that the medicinal effect can directly reach the disease site and realize both internal and external treatment, shorten the treatment cycle, and improve the treatment effect.
2.本发明的制备方法简单,采用文火煎煮各味中药原料,使得中药原料中的有效成分得到最大程度浸出,得到稠膏;然后采用中低温烘干、翻炒药渣,研磨成药粉,最后将稠膏和药粉混合使用,制备的中药贴全方位保留了中药原料的有效成分,使得中药贴的有效成分能够最大程度地被患者吸收。 2. The preparation method of the present invention is simple, adopts simmering decoction of various Chinese medicine raw materials, so that the active ingredients in the Chinese medicine raw materials are leached to the greatest extent to obtain a thick paste; then dry at medium and low temperatures, stir-fry the medicine dregs, grind into medicine powder, Finally, the thick ointment and the medicinal powder are mixed, and the prepared traditional Chinese medicine patch retains the active ingredients of the raw materials of the traditional Chinese medicine in all directions, so that the active ingredients of the traditional Chinese medicine patch can be absorbed by the patient to the greatest extent.
另外,本方法采用传统的煎煮和研磨复配而成,制得的中药膏副作用小,对人体皮肤或伤口没有刺激性,疗程短,治愈率高,成本低,具有广阔的市场前景。In addition, the method is compounded by traditional decoction and grinding, and the prepared traditional Chinese medicine ointment has few side effects, no irritation to human skin or wounds, short treatment period, high cure rate, low cost, and has broad market prospects.
具体实施方式detailed description
下面结合实施例对本发明作进一步描述。The present invention will be further described below in conjunction with embodiment.
实施例一Embodiment one
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑3份、艾草20份、花椒10份、冬瓜皮5份、桂皮5份、蜂蜜20份、蛋黄40份、当归10份、松节油10份。A traditional Chinese medicine ointment for treating chilblain, comprising the following raw materials in parts by weight: 3 parts of camphor, 20 parts of wormwood, 10 parts of Chinese prickly ash, 5 parts of wax gourd skin, 5 parts of cinnamon bark, 20 parts of honey, 40 parts of egg yolk, 10 parts of angelica, turpentine 10 servings.
其制备方法,包括以下步骤:Its preparation method comprises the following steps:
(1)将樟脑、艾草、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,取鸡蛋对表面进行清洗后,使用一次性注射器抽取其蛋黄备用;(1) Remove impurities from camphor, mugwort, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry for later use, take eggs to clean the surface, and use a disposable syringe to extract the egg yolk for later use;
(2)按配方称取樟脑、当归、艾草、花椒、冬瓜皮、桂皮并混合,加入15倍药材总重量的水,浸泡30min后,煎煮2小时,过滤,得到滤液和滤渣,备用;(2) Weigh and mix camphor, angelica, mugwort, Zanthoxylum bungeanum, wax gourd skin, and cinnamon bark according to the formula, add water 15 times the total weight of medicinal materials, soak for 30 minutes, decoct for 2 hours, filter to obtain filtrate and filter residue, and set aside;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.36的稠膏;将步骤(2)中得到的滤渣烘干,然后研磨成250目的粉末,在60℃条件下烘干6h,并使用小火炒至棕黄色,得到药粉;(3) Heat the filtrate obtained in step (2), add honey to the filtrate, and concentrate to obtain a thick paste with a density of 1.36 relative to water; dry the filter residue obtained in step (2), and then grind it into 250-mesh powder, dried at 60°C for 6 hours, and stir-fried on low heat until brown-yellow, to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并使用注射器向其中加入蛋黄和松节油,搅拌20min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), add egg yolk and turpentine into it with a syringe, stir for 20 minutes until the mixture is uniform, and prepare a traditional Chinese medicine ointment.
实施例二Embodiment two
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑3.5份、艾草25份、花椒15份、冬瓜皮6份、桂皮6份、蜂蜜22份、蛋黄45份、当归12份、松节油12份。A traditional Chinese medicine ointment for treating frostbite, comprising the following raw materials in parts by weight: 3.5 parts of camphor, 25 parts of wormwood, 15 parts of Chinese prickly ash, 6 parts of wax gourd skin, 6 parts of cinnamon bark, 22 parts of honey, 45 parts of egg yolk, 12 parts of angelica, turpentine 12 servings.
其制备方法,包括以下步骤:Its preparation method comprises the following steps:
(1)将樟脑、艾草、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,取鸡蛋对表面进行清洗后,使用一次性注射器抽取其蛋黄备用;(1) Remove impurities from camphor, mugwort, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry for later use, take eggs to clean the surface, and use a disposable syringe to extract the egg yolk for later use;
(2)按配方称取樟脑、当归、艾草、花椒、冬瓜皮、桂皮并混合,加入16倍药材总重量的水,浸泡35min后,煎煮2小时,过滤,得到滤液和滤渣,备用;(2) Weigh and mix camphor, angelica, mugwort, Zanthoxylum bungeanum, wax gourd skin, and cinnamon bark according to the formula, add water 16 times the total weight of medicinal materials, soak for 35 minutes, decoct for 2 hours, filter to obtain filtrate and filter residue, and set aside;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.37的稠膏;将步骤(2)中得到的滤渣烘干,然后研磨成260目的粉末,在60℃条件下烘干7h,并使用小火炒至棕黄色,得到药粉;(3) Heat the filtrate obtained in step (2) with low heat, add honey to the filtrate, concentrate to obtain a thick paste with a density of 1.37 relative to water; dry the filter residue obtained in step (2), and then grind it into 260-mesh powder, dried at 60°C for 7 hours, and stir-fried on low heat until brown-yellow to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并使用注射器向其中加入蛋黄和松节油,搅拌25min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), add egg yolk and turpentine into it using a syringe, stir for 25 minutes until the mixture is uniform, and prepare a traditional Chinese medicine ointment.
实施例三Embodiment Three
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑4份、祁艾的叶25份、花椒15份、冬瓜皮10份、桂皮8份、蜂蜜25份、蛋黄50份、当归14份、松节油13份。A traditional Chinese medicine ointment for treating frostbite, comprising the following raw materials in parts by weight: 4 parts of camphor, 25 parts of Qiai leaves, 15 parts of Chinese prickly ash, 10 parts of wax gourd skin, 8 parts of cinnamon bark, 25 parts of honey, 50 parts of egg yolk, and 14 parts of angelica , 13 parts of turpentine.
其制备方法,包括以下步骤:Its preparation method comprises the following steps:
(1)将樟脑、艾草、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,取鸡蛋对表面进行清洗后,使用一次性注射器抽取其蛋黄备用;(1) Remove impurities from camphor, mugwort, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry for later use, take eggs to clean the surface, and use a disposable syringe to extract the egg yolk for later use;
(2)按配方称取樟脑、当归、艾草、花椒、冬瓜皮、桂皮并混合,加入17倍药材总重量的水,浸泡45min后,煎煮3小时,过滤,得到滤液和滤渣,备用;(2) Weigh and mix camphor, angelica, mugwort, Zanthoxylum bungeanum, wax gourd skin, and cinnamon bark according to the formula, add water 17 times the total weight of medicinal materials, soak for 45 minutes, decoct for 3 hours, filter to obtain filtrate and filter residue, and set aside;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.38的稠膏;将步骤(2)中得到的滤渣烘干,然后研磨成270目的粉末,在62℃条件下烘干8h,并使用小火炒至棕黄色,得到药粉;(3) Heat the filtrate obtained in step (2), add honey to the filtrate, and concentrate to obtain a thick paste with a density of 1.38 relative to water; dry the filter residue obtained in step (2), and then grind it into 270-mesh powder, dried at 62°C for 8 hours, and fried on a low heat until brown-yellow, to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并使用注射器向其中加入蛋黄和松节油,搅拌28min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), and add egg yolk and turpentine into it using a syringe, and stir for 28 minutes until the mixture is uniform, and the traditional Chinese medicine ointment is prepared.
实施例四Embodiment four
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑4份、艾草30份、花椒20份、冬瓜皮10份、桂皮10份、蜂蜜25份、蛋黄50份、当归15份、松节油15份。A traditional Chinese medicine ointment for treating frostbite, comprising the following raw materials in parts by weight: 4 parts of camphor, 30 parts of wormwood, 20 parts of Chinese prickly ash, 10 parts of wax gourd skin, 10 parts of cinnamon bark, 25 parts of honey, 50 parts of egg yolk, 15 parts of angelica, turpentine 15 servings.
其制备方法,包括以下步骤:Its preparation method comprises the following steps:
(1)将樟脑、祁艾的叶、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,先将鸡蛋清洗并使用臭氧对表面消毒,破壳后使用一次性注射器抽取蛋黄备用;(1) Remove impurities from camphor, Qiai leaves, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry them for later use, first wash the eggs and sterilize the surface with ozone, and use a disposable syringe to extract the egg yolk for later use;
(2)按配方称取樟脑、当归、祁艾的叶、花椒、冬瓜皮、桂皮并混合,加入17.5倍药材总重量的水,浸泡45min后,煎煮3小时,过滤,得到滤液和滤渣,备用;(2) Weigh and mix camphor, angelica, Qiai leaves, prickly ash, wax gourd skin, and cinnamon bark according to the formula, add water 17.5 times the total weight of medicinal materials, soak for 45 minutes, decoct for 3 hours, filter to obtain filtrate and filter residue, spare;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.38的稠膏;将步骤(2)中得到的滤渣烘干,然后研磨成300目的粉末,在65℃条件下烘干9h,并使用小火炒至棕黄色,得到药粉;(3) Heat the filtrate obtained in step (2), add honey to the filtrate, and concentrate to obtain a thick paste with a density of 1.38 relative to water; dry the filter residue obtained in step (2), and then grind it into 300-mesh powder, dried at 65°C for 9 hours, and stir-fried on low heat until brown-yellow, to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并使用注射器向其中加入蛋黄和松节油,搅拌30min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), add egg yolk and turpentine into it using a syringe, stir for 30 minutes until the mixture is uniform, and obtain a traditional Chinese medicine ointment.
本实施例中,制备方法步骤(1)使用臭氧对鸡蛋表面进行杀菌消毒,防止鸡蛋壳上的大肠杆菌、金黄色葡萄球菌、白色念珠菌等致病菌影响中药膏的药性,增加其药性的吸收率。In this example, the preparation method step (1) uses ozone to sterilize the surface of eggs to prevent Escherichia coli, Staphylococcus aureus, Candida albicans and other pathogenic bacteria on egg shells from affecting the medicinal properties of traditional Chinese medicine ointment and increase its medicinal properties. Absorption rate.
实施例五Embodiment five
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑4份、祁艾的叶30份、花椒20份、冬瓜皮10份、桂皮10份、芦荟5份、蜂蜜25份、蛋黄50份、当归15份、松节油15份。A traditional Chinese medicine ointment for treating frostbite, comprising the following raw materials in parts by weight: 4 parts of camphor, 30 parts of Qiai leaves, 20 parts of Chinese prickly ash, 10 parts of wax gourd skin, 10 parts of cinnamon bark, 5 parts of aloe vera, 25 parts of honey, and 50 parts of egg yolk , 15 parts of angelica, 15 parts of turpentine.
其制备方法,包括以下步骤:Its preparation method comprises the following steps:
(1)将樟脑、祁艾的叶、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,先将鸡蛋清洗并使用臭氧对表面消毒,破壳后使用一次性注射器抽取蛋黄备用;(1) Remove impurities from camphor, Qiai leaves, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry them for later use, first wash the eggs and sterilize the surface with ozone, and use a disposable syringe to extract the egg yolk for later use;
(2)按配方称取樟脑、当归、祁艾的叶、花椒、冬瓜皮、桂皮并混合,加入17.5倍药材总重量的水,浸泡50min后,煎煮3小时,过滤,得到滤液和滤渣,备用;(2) Weigh and mix camphor, angelica, Qiai leaves, pepper, wax gourd skin, and cinnamon according to the formula, add water 17.5 times the total weight of medicinal materials, soak for 50 minutes, decoct for 3 hours, filter to obtain filtrate and filter residue, spare;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.38的稠膏;将步骤(2)中得到的滤渣烘干,然后粉碎并研磨成300目的粉末,在65℃条件下9h,并采用小火炒至棕黄色,得到药粉;(3) Slowly heat the filtrate obtained in step (2), add honey to the filtrate, concentrate to obtain a thick paste with a density of 1.38 relative to water; dry the filter residue obtained in step (2), then crush and Grind into 300-mesh powder, stir-fry at 65°C for 9 hours until brown-yellow in low heat to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并使用注射器向其中加入蛋黄和松节油,之后加入芦荟进行搅拌30min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), add egg yolk and turpentine into it using a syringe, and then add aloe vera and stir for 30 minutes until the mixture is evenly mixed to obtain a traditional Chinese medicine ointment.
本实施例中,制备方法步骤(3)先将烘干后的滤渣进行粉碎在进行研磨,有利于提高研磨的效率,而且在辅料中增加芦荟,利用芦荟具有特殊的凝胶状,使制得的药膏形状更好,而且芦荟可进一步对症状处的皮肤进行滋养,提高本发明的润肤效果。In this example, the step (3) of the preparation method first crushes the dried filter residue before grinding, which is beneficial to improve the efficiency of grinding, and adds aloe vera in the auxiliary material, and utilizes the special gelatinous shape of aloe vera to make the obtained The shape of the ointment is better, and the aloe vera can further nourish the skin at the symptom, and improve the moisturizing effect of the present invention.
实施例六Embodiment six
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑4份、艾草35份、花椒25份、冬瓜皮12份、桂皮12份、蜂蜜25份、蛋黄50份、当归16份、松节油15份。A traditional Chinese medicine ointment for treating frostbite, comprising the following raw materials in parts by weight: 4 parts of camphor, 35 parts of wormwood, 25 parts of Chinese prickly ash, 12 parts of wax gourd skin, 12 parts of cinnamon bark, 25 parts of honey, 50 parts of egg yolk, 16 parts of angelica, turpentine 15 servings.
其制备方法,包括以下步骤:Its preparation method comprises the following steps:
(1)将樟脑、艾草、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,取鸡蛋对表面进行清洗后,使用一次性注射器抽取其蛋黄备用;(1) Remove impurities from camphor, mugwort, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry for later use, take eggs to clean the surface, and use a disposable syringe to extract the egg yolk for later use;
(2)按配方称取樟脑、当归、艾草、花椒、冬瓜皮、桂皮并混合,加入18倍药材总重量的水,浸泡50min后,煎煮3小时,过滤,得到滤液和滤渣,备用;(2) Weigh and mix camphor, angelica, mugwort, Zanthoxylum bungeanum, wax gourd skin, and cinnamon bark according to the formula, add water 18 times the total weight of medicinal materials, soak for 50 minutes, decoct for 3 hours, filter to obtain filtrate and filter residue, and set aside;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.38的稠膏;将步骤(2)中得到的滤渣烘干,然后研磨成300目的粉末,在60℃条件下烘干10h,并采用小火炒至棕黄色,得到药粉;(3) Heat the filtrate obtained in step (2), add honey to the filtrate, and concentrate to obtain a thick paste with a density of 1.38 relative to water; dry the filter residue obtained in step (2), and then grind it into 300-mesh powder, dried at 60°C for 10 hours, and stir-fried on low heat until brown-yellow, to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并使用注射器向其中加入蛋黄和松节油,搅拌30min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), add egg yolk and turpentine into it using a syringe, stir for 30 minutes until the mixture is uniform, and obtain a traditional Chinese medicine ointment.
实施例七Embodiment seven
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑4.5份、艾草38份、花椒28份、冬瓜皮14份、桂皮13份、蜂蜜28份、蛋黄55份、当归18份、松节油17份。A traditional Chinese medicine ointment for treating frostbite, comprising the following raw materials in parts by weight: 4.5 parts of camphor, 38 parts of wormwood, 28 parts of Chinese prickly ash, 14 parts of wax gourd skin, 13 parts of cinnamon bark, 28 parts of honey, 55 parts of egg yolk, 18 parts of angelica, turpentine 17 servings.
其制备方法,包括以下步骤:Its preparation method comprises the following steps:
(1)将樟脑、艾草、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,取鸡蛋对表面进行清洗后,使用一次性注射器抽取其蛋黄备用;(1) Remove impurities from camphor, mugwort, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry for later use, take eggs to clean the surface, and use a disposable syringe to extract the egg yolk for later use;
(2)按配方称取樟脑、当归、艾草、花椒、冬瓜皮、桂皮并混合,加入19倍药材总重量的水,浸泡55min后,煎煮3.5小时,过滤,得到滤液和滤渣,备用;(2) Weigh and mix camphor, angelica, wormwood, Zanthoxylum bungeanum, wax gourd skin, and cinnamon bark according to the formula, add 19 times the total weight of medicinal materials in water, soak for 55 minutes, decoct for 3.5 hours, filter to obtain filtrate and filter residue, and set aside;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.39的稠膏;将步骤(2)中得到的滤渣烘干,然后研磨成300目的粉末,在63℃条件下烘干11h,并采用小火炒至棕黄色,得到药粉;(3) Heat the filtrate obtained in step (2) with low heat, add honey to the filtrate, and concentrate to obtain a thick paste with a density of 1.39 relative to water; dry the filter residue obtained in step (2), and then grind it into 300-mesh powder, dried at 63°C for 11 hours, and fried on low heat until brown-yellow, to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并使用注射器向其中加入蛋黄和松节油,搅拌35min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), add egg yolk and turpentine into it using a syringe, stir for 35 minutes until the mixture is uniform, and obtain a traditional Chinese medicine ointment.
实施例八Embodiment Eight
一种治疗冻疮的中药膏,包括以下重量份的原料:樟脑5份、艾草40份、花椒30份、冬瓜皮15份、桂皮15份、蜂蜜30份、蛋黄60份、当归20份、松节油20份。A traditional Chinese medicine ointment for treating frostbite, comprising the following raw materials in parts by weight: 5 parts of camphor, 40 parts of wormwood, 30 parts of Chinese prickly ash, 15 parts of wax gourd skin, 15 parts of cinnamon, 30 parts of honey, 60 parts of egg yolk, 20 parts of angelica, turpentine 20 servings.
其制备方法,包括以下步骤:Its preparation method comprises the following steps:
(1)将樟脑、艾草、花椒、冬瓜皮、桂皮、当归去除杂质、清洗干燥后备用,取鸡蛋对表面进行清洗后,使用一次性注射器抽取其蛋黄备用;(1) Remove impurities from camphor, mugwort, Chinese prickly ash, wax gourd skin, cinnamon bark, and angelica, wash and dry for later use, take eggs to clean the surface, and use a disposable syringe to extract the egg yolk for later use;
(2)按配方称取樟脑、当归、艾草、花椒、冬瓜皮、桂皮并混合,加入20倍药材总重量的水,浸泡60min后,煎煮4小时,过滤,得到滤液和滤渣,备用;(2) Weigh and mix camphor, angelica, wormwood, Zanthoxylum bungeanum, wax gourd skin, and cinnamon bark according to the formula, add 20 times the total weight of medicinal materials in water, soak for 60 minutes, decoct for 4 hours, filter to obtain filtrate and filter residue, and set aside;
(3)将步骤(2)中得到的滤液文火加热,并在滤液中添加蜂蜜,浓缩得到相对于水的密度为1.40的稠膏;将步骤(2)中得到的滤渣烘干,然后研磨成300目的粉末,在65℃条件下烘干12h,并采用小火炒至棕黄色,得到药粉;(3) Heat the filtrate obtained in step (2), add honey to the filtrate, and concentrate to obtain a thick paste with a density of 1.40 relative to water; dry the filter residue obtained in step (2), and then grind it into 300-mesh powder, dried at 65°C for 12 hours, and fried on low heat until brown-yellow, to obtain medicinal powder;
(4)将步骤(3)得到的稠膏、药粉混合,并使用注射器向其中加入蛋黄和松节油,搅拌40min至混合均匀,制得中药膏。(4) Mix the thick ointment and medicinal powder obtained in step (3), add egg yolk and turpentine into it with a syringe, stir for 40 minutes until the mixture is uniform, and obtain a traditional Chinese medicine ointment.
临床试验Clinical Trials
一、试验病例1. Test case
近两年来,共收治面冻疮249例,其中男患者数量为156例,年龄梯度3-72岁,女患者数量为93例,年龄梯度为4-65岁。In the past two years, a total of 249 cases of facial frostbite have been treated, including 156 male patients with an age gradient of 3-72 years old, and 93 female patients with an age gradient of 4-65 years old.
二、诊断标准2. Diagnostic criteria
症状包括:好发于四肢末梢及暴露部位,常见于患者手足背面,分布对称,常有特殊虹膜样损害,有时可见于面部、臀、口腔等处。表现为紫红色肿块、皮温低、遇冷麻木、遇热则痒,严重者易形成水疱溃疡,溃疡愈合后遗留萎缩性疤痕。Symptoms include: often occur in the extremities and exposed parts, often in the back of the patient's hands and feet, symmetrically distributed, often have special iris-like lesions, sometimes seen in the face, buttocks, mouth, etc. It manifests as a purple-red mass, low skin temperature, numbness when cold, and itching when hot. In severe cases, blisters and ulcers are easily formed, and atrophic scars are left after the ulcers heal.
三、治疗方法3. Treatment
将皮肤洗净后擦干,将本发明的中药膏涂覆在症状部位,早晚各涂覆一次,五天为一疗程,临床症状较轻患者用药1个疗程、较重患者用药2个疗程;治疗期间禁辛辣、油腻、寒凉食物,避免儿童口食。After cleaning the skin, dry it, and apply the Chinese medicinal ointment of the present invention on the symptomatic part, once in the morning and evening, five days as a course of treatment, 1 course of treatment for patients with mild clinical symptoms, and 2 courses of treatment for patients with severe symptoms; During the treatment period, spicy, greasy, and cold food are forbidden, and children should not eat by mouth.
四、疗效评价标准4. Efficacy Evaluation Criteria
治愈:各症状全部消失,冻疮皮肤止痒、消肿、肤色正常、无萎缩疤痕。Cure: all symptoms disappeared, chilblain skin relieved itching, detumescence, normal skin color, no atrophic scar.
显效:无明显症状和体征,止痒消肿,但是症状处仍为红色。Significant effect: no obvious symptoms and signs, itching and swelling are relieved, but the symptoms are still red.
无效:主观症状和客观体征无改善。Ineffective: No improvement in subjective symptoms and objective signs.
五、结果5. Results
对249例冻疮进行治疗,总有效率达97%,治愈率达93%,治疗效果显著。249 cases of frostbite were treated, the total effective rate was 97%, the cure rate was 93%, and the treatment effect was remarkable.
典型病例Typical cases
病例1:李某,男,3岁,河南方城人,2015年冬,患冻疮约一周,在当地多次治疗效果不明显,到我处就诊时,患者右手中指关节处出现红肿,并伴随痛痒症状。采用本发明的实施例4的外用药物涂覆三天后,临床症状消失。停药两个月后电话随访未曾复发。Case 1: Mr. Li, male, 3 years old, from Fangcheng, Henan, suffered from chilblain for about a week in the winter of 2015, and the effect of multiple treatments in the local area was not obvious. Itchy symptoms. After three days of application of the external drug of Example 4 of the present invention, the clinical symptoms disappeared. Two months after drug withdrawal, there was no recurrence in telephone follow-up.
2. 董某,男,16岁,河南桐柏人,一年前患有右手手部侧方冻疮,经治疗后效果不佳,2015年冬于原位置重新出现冻疮,到我处就诊时,症状为红肿、水泡,并伴随疼痛症状。采用本发明的实施例4的外用药物涂覆一个疗程后,临床症状消失。停药两个月后电话随访未曾复发,也未出现皮肤疤痕现象。2. Dong, male, 16 years old, from Tongbai, Henan Province, suffered from chilblain on the side of his right hand a year ago, and the effect was not good after treatment. In the winter of 2015, frostbite reappeared at the original location. When he came to our office for treatment, Symptoms are redness, swelling, blisters, and accompanied by painful symptoms. After one course of treatment was applied with the externally applied medicament of Example 4 of the present invention, the clinical symptoms disappeared. Two months after stopping the drug, there was no recurrence and no skin scars in the telephone follow-up.
3. 李某某,男,71岁,河南桐柏人,2015年冬,患冻疮约十天,到我处就诊时,患者双耳耳垂出现红肿、皴裂。采用本发明的实施例4的外用药物涂覆一个疗程后,临床症状消失。停药两个月后电话随访未曾复发。3. Li Moumou, male, 71 years old, from Tongbai, Henan, suffered from frostbite for about ten days in the winter of 2015. When he came to our clinic, the patient's earlobes were red, swollen and cracked. After one course of treatment was applied with the externally applied medicament of Example 4 of the present invention, the clinical symptoms disappeared. Two months after drug withdrawal, there was no recurrence in telephone follow-up.
4. 马某,女,23岁,河南南阳人,2014年冬来我所就诊,就诊时,左症状为脸部面红肿、僵硬,局部皮肤发黑。采用本发明的实施例5的外用药物涂覆两个疗程后,临床症状消失。停药两个月后电话随访未曾复发。4. Ma, female, 23 years old, from Nanyang, Henan Province, came to our clinic for treatment in the winter of 2014. At the time of treatment, the left symptom was facial redness, swelling, stiffness, and local skin darkening. After two courses of treatment were applied with the external drug of Example 5 of the present invention, the clinical symptoms disappeared. Two months after drug withdrawal, there was no recurrence in telephone follow-up.
5. 陈某某,女,46岁,河南平顶山鲁山县人,2016年春来我所就诊,就诊时,左症状为手指多处出现痛痒、溃疡。采用本发明的实施例5的外用药物涂覆两个疗程后,临床症状消失,皮肤恢复如初。停药一个月后电话随访未曾复发。5. Chen Moumou, female, 46 years old, from Lushan County, Pingdingshan, Henan Province, came to our clinic in the spring of 2016. When she went to see a doctor, her left symptoms were multiple itches and ulcers on her fingers. After two courses of treatment were applied with the external drug of Example 5 of the present invention, the clinical symptoms disappeared and the skin recovered. One month after drug withdrawal, there was no recurrence in telephone follow-up.
最后说明的是,以上实施例仅用以说明本发明的技术方案而非限制,本领域普通技术人员对本发明的技术方案所做的其他修改或者等同替换,只要不脱离本发明技术方案的精神和范围,均应涵盖在本发明的权利要求范围当中。Finally, it is noted that the above embodiments are only used to illustrate the technical solution of the present invention without limitation, other modifications or equivalent replacements made by those skilled in the art to the technical solution of the present invention, as long as they do not depart from the spirit and spirit of the technical solution of the present invention All should be included in the scope of the claims of the present invention.
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