CN101091786A - Sticking ointment of composition of Chinese traditional medicine for treating asthma, preparation method - Google Patents
Sticking ointment of composition of Chinese traditional medicine for treating asthma, preparation method Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine adhesive plaster for effectively curing cough and asthma with obvious therapeutic effect and its preparation method. Said Chinese medicine adhesive plaster is made up by using 5 Chinese medicinal materials of ephedra root, corydalis tuber, white mustard seed, bitter apricot kernel and fresh ginger and adding some auxiliary materials through a certain preparation method. Said invention also provides the concrete steps of its preparation method.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition plaster for the treatment of asthma and preparation method thereof.
Background technology
Bronchial asthma (bronchial asthma) is because anaphylaxis or other factors cause the bronchus diffuse spasm, a kind of chronic disease that ictal classical symptoms such as expiratory dyspnea with wheezing sound occur also can be considered a kind of specific type of chronic obstructive bronchitis.Asthma is the complexity disease of serious harm each age group population health, and there are nearly 2,000 ten thousand asthmatic patients in China.Therefore, the medicine of development prevention and treatment asthma is significant.
(β-AR) agonist is a principal agent of preventing and treating asthma at present, but the two has side effect clinically for non-specific anti-inflammatory agent glucocorticoid (GC) and adrenoreceptor.By comparison, Chinese medicine has a long history on treatment asthma, has also accumulated rich experience.
The point-application method is the treatment asthma method that Chinese medicine shows unique characteristics.Clear Zhang Lu with regard to this therapy of write up, extremely praises highly its curative effect in " the Zhang Shi doctor is logical ".Since the fifties in last century, clinical research has widely been carried out to this method in national different regions, has verified this therapy for relief of symptoms, postpones or reduces recurrence, and shortening stage of attack all has definite curative effect.The idea of " forcing on and controlling asthma " is extensively approved by the people, and is used widely.Application method treatment asthma, though have good effect, at present clinically the patient with pulverizing medicinal materials after with Sucus Zingberis furnishing pasty state, the dosage form simple coarse, quality and drug effect instability have limited its extensive use clinically.
Cataplasma belongs to the matrix type transdermal delivery system, has that drug loading is big, good permeability, skin irritation are little, can take off subsides repeatedly, do not have distinguishing features such as the pain of epilation, good patient compliance.With respect to the Chinese medicine external preparation, as rubber cream and black plaster etc., crust cloth cream has more advantages and remarkable advantages more.But the component of cataplasma and forming technique are very big to the skin permeation rate influence of crust adhesive plaster thing composition, also and then influence its curative effect.
The present invention is according to traditional Chinese medical science tradition application experience, the clinical demand of asthmatic patient, and this Chinese medicine composition clinical practice and modern pharmacology result of study etc., Chinese medicine composition is made extractum through modern extraction and separation technology, be mixed and made into plaster by molding technology and water-soluble base, improved clinical efficacy and drug safety.
Summary of the invention
The Chinese medicine composition plaster of treatment cough with asthma of the present invention is made up of active constituents of medicine, substrate and carrier, and this pharmaceutical composition comprises Herba Ephedrae, Rhizoma Corydalis, Semen Sinapis, Semen Armeniacae Amarum, Rhizoma Zingiberis Recens.Described substrate includes binding agent, wetting agent, filler, cross-linking agent and transdermal enhancer.Carrier is meant backing and protective layer.Therefore, this patch is formed by three layers: i.e. backing layer, active constituents of medicine and substrate mixed layer, protective layer.
The Chinese medicine composition of treatment cough with asthma of the present invention, this pharmaceutical composition comprises (weight ratio):
Herba Ephedrae 5-30 part Rhizoma Corydalis 5-30 part Semen Sinapis Albae 5-30 part,
Semen Armeniacae Amarum 5-30 part Rhizoma Zingiberis Recens is formed 5-30 part
Be preferably:
Herba Ephedrae 5-15 part Rhizoma Corydalis 5-15 part Semen Sinapis Albae 5-25 part
Semen Armeniacae Amarum 5-15 part Rhizoma Zingiberis Recens is formed 5-20 part.
More preferably:
10 parts of 10 parts of Semen Sinapis Albaes of 10 parts of Rhizoma Corydalis of Herba Ephedrae
10 parts in 10 portions of Rhizoma Zingiberis Recenss of Semen Armeniacae Amarum
This preparation of drug combination method is as follows:
Herba Ephedrae, Rhizoma Corydalis, Semen Sinapis, Semen Armeniacae Amarum, Rhizoma Zingiberis Recens powder are broken into coarse powder, and water or aquiferous ethanol extract, and filtering, be condensed into relative density is 1.2-1.5 (40-80 ℃), is preferably the extractum of 1.2-1.3 (40-80 ℃); With the ethanol precipitation of gained extractum with 50-80%, the filtering precipitation, supernatant concentration becomes 1.2-1.5 (40-80 ℃), is preferably the extractum of 1.2-1.3 (40-80 ℃).
Gained extractum includes (weight ratio) through high effective liquid chromatography for measuring:
Ephedrine 5-100 part pseudoephedrine 2-50 part tetrahydropalmatine 1-80 part
The plain 1-100 part of Rhizoma Corydalis first sinalbin 0.01-150 part amygdaloside 10-300 part
Sinapic acid choline ester. 0.01-230 part zingiberol 0.1-100 part zingiberene 0.2-150 part.
Be preferably:
Ephedrine 50-300 part pseudoephedrine 50-350 part tetrahydropalmatine 1-30 part
The plain 0.01-200 part of Rhizoma Corydalis first sinalbin 0.01-150 part amygdaloside 50-500 part
Sinapic acid choline ester. 0.1-50 part zingiberol 0.1-50 part zingiberene 0.2-50 part
More preferably:
300 parts of 5 parts of amygdalosides of 100 parts of tetrahydropalmatines of ephedrine
5 parts of 5 parts of zingiberols of sinapic acid choline ester.
Patch of the present invention, it is a kind of hydrophilic matrix, this type of substrate all has application both at home and abroad in the external preparation, and has the patent of many relevant these type of substrate to announce, as United States Patent (USP) 635526, Chinese patent 99113612.8, but the present both at home and abroad contained substrate of having announced of patent documentation, after this pharmaceutical composition mixed, the zoopery result did not obtain desired therapeutic effect, with the ephedrine is the transdermal test in vitro experiment that index is carried out, and shows that also the transmitance of this active component is lower.
According to research document of having delivered at present and the patent documentation of having announced, medicine, particularly Chinese medicine composition also are described, should with the cooperating of corresponding hydrophilic matrix, its given activity composition could see through skin, enters blood circulation, brings into play therapeutical effect.Therefore, substrate is formed and preparation technology influences the cataplasma physicochemical properties, as the qualitative, quantitative of skin permeation rate, active component or the composition of outward appearance, plastic property, tack, cream content, each component etc.The present invention tests through the transdermal test in vitro of system, and filters out the substrate composition that is fit to this pharmaceutical composition in conjunction with pharmacodynamic experiment, and corresponding preparation method.
The detailed preparation method of described plaster of the present invention is as follows:
Herba Ephedrae, Rhizoma Corydalis, Semen Sinapis, Semen Armeniacae Amarum are ground into coarse powder, and water or aquiferous ethanol extract, and filtering, be condensed into relative density is 1.2-1.5 (40-80 ℃), is preferably the extractum of 1.2-1.3 (40-80 ℃); With gained extractum with the ethanol precipitation of 50-80%, the filtering precipitation, supernatant concentration becomes 1.2-1.5 (40-80 ℃), is preferably the extractum of 1.2-1.3 (40-80 ℃), Rhizoma Zingiberis Recens is squeezed the juice, mix with gained extractum clear paste.With carbomer, polyvinyl alcohol its abundant swelling that makes soluble in water, add above-mentioned clear paste, stirring is the A phase; Gelatin, glycerol and an amount of propylene glycol and ethanol are dissolved each other, add sodium polyacrylate under the stirring at low speed respectively, the back that stirs is as the B phase, and Kaolin is dissolved in the water as C mutually with transdermal enhancer.Stirring condition mixes C with B earlier down mutually mutually, adds the A phase then, stirs, and coats on the non-woven fabrics, smokes, and covers anti-glutinous layer, promptly.
Preparation method mesostroma (weight ratio) is:
Carbomer 2-10 part sodium polyacrylate 2-10 part polyvinyl alcohol 10-15 part
Gelatin 5-20 part Kaolin 3-10 part glycerol 10-30 part water is an amount of.
Be preferably:
10 parts of 7 parts of polyvinyl alcohols of 5 parts of sodium polyacrylates of carbomer
20 parts of water of 3 parts of glycerol of 8 parts of Kaolin of gelatin are an amount of.
Also comprise transdermal enhancer in the substrate, the weight ratio of active constituents of medicine and transdermal enhancer is 50-100: 1, and transdermal enhancer is selected from one or more mixture in Mentholum, Borneolum Syntheticum, the Oleum Caryophylli.
The chemical constituent and the penetration enhancer of the composition substrate of this patch, and the mixed method of active constituents of medicine and substrate, promptly preparation method is remarkable to the therapeutic effect influence of this patch.
This plaster is after acupuncture point or part stick, and the active constituents of medicine percutaneous enters blood circulation, reaches therapeutic purposes, and animal model experiment has proved the remarkable result of the treatment asthma of this plaster.
Modern medicine thinks that asthma is a kind of syndrome, it is characterized by in various degree airway obstruction and air flue hyperreaction, and is the syndrome group by the breathing that airway inflammation causes.Most scholars think that it is a kind of chronic eosinophilic granulocyte's property bronchitis, be by T cell-mediated based on mastocyte and oxyphil cell, the bronchial mucosa chronic inflammatory disease that multiple-cell participates in is a kind of anaphylaxis of tardy property air flue.So the treatment of asthma emphasis has been changed into by simple controlling symptoms and has alleviated or suppresses airway inflammation, reduces airway reactivity and prevention of asthma and shows effect.Nonspecific inflammation is the important pathologic basis of bronchial asthma in a word, suppresses the activation of inflammatory cell and the release of inflammatory mediator.
It is method commonly used both at home and abroad at present that ovalbumin excites the Cavia porcellus asthma attack, and its method is simple, and it is more directly perceived to examine index.Reproducibility is strong, and Cavia porcellus is the feature animal of best demonstration airway hyper-reaction type, and its asthma attack is similar to people's performance.Therefore, the present invention adopts ovalbumin to excite Cavia porcellus and rat asthmatic model model, and to the antiasthmatic effect of described pharmaceutical composition, to influence of Pulmonary Function, and the effect of the release of the activation of inhibition inflammatory cell and inflammatory mediator is studied.
Experiment uses Cavia porcellus in the 0th day, the 7th day respectively at both sides thigh outside intramuscular injection 4% ovalbumin normal saline solution 0.1～0.2ml, while lumbar injection 4% gel aluminum hydroxide 0.2ml, sensitized animal, from sensitization second day, animal is divided into the large, medium and small dosage group of pharmaceutical composition, positive controls, model group and blank group at random.
The large, medium and small dosage group of pharmaceutical composition day dosage is respectively 4,8,16 times of Coming-of-Age Day dosage, is 3.0g/kg, 6.0g/kg, 12.0g/kg crude drug amount.Positive controls gives dexamethasone (1mg/kg/d) plaster, every 0.75mg (Tianjin Lisheng Pharmaceutical Co., Ltd.).Model group is given blank substrate, and blank group is given normal saline.
Be cut into the crust cloth cream of respective area by the body weight of Cavia porcellus, the bilateral fei shu, Hsinshu (acupoint), the ke shu that rose to be applied to Cavia porcellus in the 10th day, and with immobilization with adhesive tape, every day 1 time, each 6h, applying ointment or plaster preceding is the center unhairing with the acupuncture point with curved scissors, eye scissors and shaver, and preserved skin was 1 time in per 3 days, and acupuncture point basis on location list of references is determined.
Played administration after 1 hour on the 14th day, and placed Cavia porcellus to place in the airtight container of 4L (self-control) Cavia porcellus, excite with 1% ovalbumin normal saline constant-pressure atomization, the atomizing flow is 3ml/min; Spray 15～20s after stopping to spray, observes and writes down drawing of the interior Cavia porcellus of 6min and breathe heavily incubation period and the number of animals that tic is fallen, continuous seven days take place.(before second and third time bring out, every guinea pig intraperitoneal injection 5mg/kg diphenhydramine.)
Experimental result shows (table 1), compares with model group, and there were significant differences (P＜0.05) for positive group and pharmaceutical composition small dose group
*, the dosage group has utmost point significant difference (P＜0.01) in the pharmaceutical composition
*, the no significant difference of the heavy dose of group of pharmaceutical composition shows small dose group and middle dosage group obvious prolonged guinea pig asthma incubation period, and demonstrates dose-effect relationship, illustrates that pharmaceutical composition of the present invention has stronger antiasthmatic effect, and acts on and be better than positive drug.
The preclinical influence of table 1 pharmaceutical composition Cavia porcellus asthma
| Group | N | Dosage (g/kg) | Draw and breathe heavily incubation period (s) |
| The heavy dose of group of this emplastrum of dosage group in this this emplastrum of emplastrum small dose group of the positive group of blank group model group | 10 10 10 10 10 10 | - - 1 6 12 24 | 0 65.00±50.751 112.67±36.547 * 113.60±73.918 * 133.09±52.363 ** 95.50±58.614 |
The experimental rat same guinea pig model that divides into groups, in 1,2,3,4,5,8,9,10,11,12 days respectively lumbar injection antigen liquid 1ml (every ml contains 100mgOVA, 100mgAL (OH)
3) sensitization, the 12nd day large, medium and small three the dosage group gastric infusions of this pharmaceutical composition plaster, 15d plays administration and after 1 hour rat is placed in the 4L bell jar, feeds 1% egg protein normal saline with the pressurization nebulizer and excites 30min, continuous 14 days.Positive controls: the rat modeling played the filling stomach on the 12nd day and gives dexamethasone (1mg/kg/d).Be made into the 0.1mg/ml normal saline.The asthmatic model group was irritated stomach on the 12nd day and is given normal saline.Blank group gives the normal saline lumbar injection, irritates stomach and sucks normal saline in atomizing in the 15th day.
Each group rats by intraperitoneal injection 12% urethane (2ml/100g) is made rat anesthesia, and air flue cuts and inserts Y type tracheal intubation.The Y-piece two ends are connected with flow velocity, pressure transducer respectively, and the corresponding end of flow sensor is connected with animal respirator.Tidal volume 10ml/kg is set, respiratory frequency 80 times/minute.Pressure, flow sensor are connected with powerlab data record analytical system respectively, measure FVC (forced vital capacity), Fev (0.2 second exhalation volume), PEF (maximum expiratory gas volume), lung function index such as Fev/FVC.
Experimental result shows, FVC (forced vital capacity), and Fev (0.2 second exhalation volume), PEF (maximum expiratory gas volume), lung function index such as Fev/FVC are compared with model group, and the positive is organized, there were significant differences (P＜0.05) for the big-and-middle small dose group of this pharmaceutical composition plaster
*, illustrate that this pharmaceutical composition plaster of the present invention can obviously improve the pulmonary function of rat.
The present invention has also carried out other pharmacological experiments proves that this pharmaceutical composition can suppress the activation of inflammatory cell and the release of inflammatory mediator.In a word, this pharmaceutical composition plaster energy relieving asthma symptoms is postponed or is reduced asthma and recurs, and shortens the asthma attack phase, and therefore, this pharmaceutical composition plaster is prevented by asthma and treatment has definite curative effect.
The specific embodiment
Embodiment 1
With Semen Sinapis Albae 10g fragmentation, Herba Ephedrae 10g, Semen Armeniacae Amarum 10g, Rhizoma Corydalis powder 10g are broken into coarse powder, with 90% alcohol reflux three times, add 4 times of amounts of ethanol for the first time, extracted 2 hours, second and third time adds 8 times of amounts of 90% ethanol, and each extracted 1 hour, left standstill, filter, merging filtrate reclaims ethanol, and it is the clear paste of 1.30～1.40 (40 ℃) that concentrating under reduced pressure becomes relative density.Rhizoma Zingiberis Recens is squeezed the juice, and with the two mix homogeneously, gets clear paste.
With carbomer 5g, polyvinyl alcohol 6g, its abundant swelling that makes soluble in water, add above-mentioned gained clear paste and stir and be the A phase; Gelatin 4g, glycerol 30g and an amount of propylene glycol are dissolved each other with ethanol, add sodium polyacrylate 8g and Kaolin 3g under the stirring at low speed respectively, stir afterwards, be dissolved in the water as the C phase as the B phase.Stirring condition mixes C with B earlier down mutually mutually, adds the A phase then, stirs, and coats on the non-woven fabrics, is put in 40 ℃ and smokes 0.5h, covers anti-glutinous layer, promptly.100 parts of ephedrines, 5 parts of tetrahydropalmatines, 300 parts of amygdalosides, 5 parts of sinapic acid choline ester .s, 5 parts of zingiberols.
Excite the experiment of Cavia porcellus and rat animal model in asthma through ovalbumin, the result shows that the gained plaster has tangible antiasthmatic effect, and the lung function index of rat also tool is improved significantly, and also can significantly suppress the activation of inflammatory cell and the release of inflammatory mediator.
Embodiment 2
With Semen Sinapis Albae 15g fragmentation, Herba Ephedrae 20g, Semen Armeniacae Amarum 20g, Rhizoma Corydalis powder 15g are broken into coarse powder, with 70% alcohol reflux three times, add 10 times of amounts of ethanol for the first time, extracted 3 hours, second and third time adds 10 times of amounts of 70% ethanol, and each extracted 1.5 hours, left standstill, filter, merging filtrate reclaims ethanol, the clear paste that concentrating under reduced pressure becomes.Rhizoma Zingiberis Recens 20g squeezes the juice, with the two mix homogeneously.
With carbomer 10g, polyvinyl alcohol 15g, its abundant swelling that makes soluble in water, add above-mentioned gained clear paste and stir and be the A phase; Gelatin 10g, glycerol 30g and an amount of propylene glycol are dissolved each other with ethanol, add sodium polyacrylate 10g and Kaolin 10g under the stirring at low speed respectively, stir afterwards, be dissolved in the water as the C phase as the B phase.Stirring condition mixes C with B earlier down mutually mutually, adds the A phase then, stirs, and coats on the non-woven fabrics, is put in 40 ℃ and smokes 0.5h, covers anti-glutinous layer, promptly.200 parts of ephedrines, 7.5 parts of tetrahydropalmatines, 600 parts of amygdalosides, 7.5 parts of sinapic acid choline ester .s, 10 parts of zingiberols.
Excite the experiment of Cavia porcellus and rat animal model in asthma through ovalbumin, the result shows that the gained plaster has tangible antiasthmatic effect, and the lung function index of rat also tool is improved significantly, and also can significantly suppress the activation of inflammatory cell and the release of inflammatory mediator.
Embodiment 3
With Semen Sinapis Albae 5g fragmentation, Herba Ephedrae 5g, Semen Armeniacae Amarum 5g, Rhizoma Corydalis powder 10g are broken into coarse powder, with 60% alcohol reflux three times, add 10 times of amounts of ethanol for the first time, extracted 1 hour, second and third time adds 10 times of amounts of 60% ethanol, and each extracted 1 hour, left standstill, filter, merging filtrate reclaims ethanol, the clear paste that concentrating under reduced pressure becomes.Rhizoma Zingiberis Recens 20g squeezes the juice, with the two mix homogeneously.
With carbomer 2g, polyvinyl alcohol 2g, its abundant swelling that makes soluble in water, add above-mentioned gained clear paste and stir and be the A phase; Gelatin 5g, glycerol 10g and an amount of propylene glycol are dissolved each other with ethanol, add sodium polyacrylate 2g and Kaolin 1g under the stirring at low speed respectively, stir afterwards, be dissolved in the water as the C phase as the B phase.Stirring condition mixes C with B earlier down mutually mutually, adds the A phase then, stirs, and coats on the non-woven fabrics, is put in 40 ℃ and smokes 0.5h, covers anti-glutinous layer, promptly.50 parts of ephedrines, 5 parts of tetrahydropalmatines, 150 parts of amygdalosides, 2.5 parts of sinapic acid choline ester .s, 10 parts of zingiberols.
Excite the experiment of Cavia porcellus and rat animal model in asthma through ovalbumin, the result shows that the gained plaster has tangible antiasthmatic effect, and the lung function index of rat also tool is improved significantly, and also can significantly suppress the activation of inflammatory cell and the release of inflammatory mediator.
Embodiment 4
With Semen Sinapis Albae 8g fragmentation, Herba Ephedrae 5g, Semen Armeniacae Amarum 10g, Rhizoma Corydalis powder 15g are broken into coarse powder, with 50% alcohol reflux three times, add 10 times of amounts of ethanol for the first time, extracted 1 hour, second and third time adds 10 times of amounts of 50% ethanol, and each extracted 2 hours, left standstill, filter, merging filtrate reclaims ethanol, the clear paste that concentrating under reduced pressure becomes.Rhizoma Zingiberis Recens 30g squeezes the juice, with the two mix homogeneously.
With carbomer 3g, polyvinyl alcohol 2g, its abundant swelling that makes soluble in water, add above-mentioned gained clear paste and stir and be the A phase; Gelatin 4g, glycerol 15g and an amount of propylene glycol are dissolved each other with ethanol, add sodium polyacrylate 3g and Kaolin 2g under the stirring at low speed respectively, stir afterwards, be dissolved in the water as the C phase as the B phase.Stirring condition mixes C with B earlier down mutually mutually, adds the A phase then, stirs, and coats on the non-woven fabrics, is put in 50 ℃ and smokes 0.5h, covers anti-glutinous layer, promptly.50 parts of ephedrines, 7.5 parts of tetrahydropalmatines, 300 parts of amygdalosides, 4 parts of sinapic acid choline ester .s, 15 parts of zingiberols.
Excite the experiment of Cavia porcellus and rat animal model in asthma through ovalbumin, the result shows that the gained plaster has tangible antiasthmatic effect, and the lung function index of rat also tool is improved significantly, and also can significantly suppress the activation of inflammatory cell and the release of inflammatory mediator.
Embodiment 5
With Semen Sinapis Albae 7g fragmentation, Herba Ephedrae 8g, Semen Armeniacae Amarum 12g, Rhizoma Corydalis powder 5g are broken into coarse powder, with 75% alcohol reflux three times, add 12 times of amounts of ethanol for the first time, extracted 1 hour, second and third time adds 10 times of amounts of 50% ethanol, and each extracted 2 hours, left standstill, filter, merging filtrate reclaims ethanol, the clear paste that concentrating under reduced pressure becomes.Rhizoma Zingiberis Recens 20g squeezes the juice, with the two mix homogeneously.
With carbomer 5g, polyvinyl alcohol 3g, its abundant swelling that makes soluble in water, add above-mentioned gained clear paste and stir and be the A phase; Gelatin 3g, glycerol 20g and an amount of propylene glycol are dissolved each other with ethanol, add sodium polyacrylate 6g and Kaolin 1g under the stirring at low speed respectively, stir afterwards, be dissolved in the water as the C phase as the B phase.Stirring condition mixes C with B earlier down mutually mutually, adds the A phase then, stirs, and coats on the non-woven fabrics, is put in 50 ℃ and smokes 1h, covers anti-glutinous layer, promptly.80 parts of ephedrines, 2. parts of tetrahydropalmatines, 320 parts of amygdalosides, 3 parts of sinapic acid choline ester .s, 10 parts of zingiberols.
Excite the experiment of Cavia porcellus and rat animal model in asthma through ovalbumin, the result shows that the gained plaster has tangible antiasthmatic effect, and the lung function index of rat also tool is improved significantly, and also can significantly suppress the activation of inflammatory cell and the release of inflammatory mediator.
Claims (10)
1, a kind of Chinese medicine composition plaster of external curing asthma comprises active constituents of medicine, blank substrate and carrier, it is characterized in that the parts by weight of pharmaceutical composition composition are:
Herba Ephedrae 5-30 part Rhizoma Corydalis 5-30 part Semen Sinapis Albae 5-30 part Semen Armeniacae Amarum 5-30 part Rhizoma Zingiberis Recens is formed 5-30 part.
2, Chinese medicine composition plaster according to claim 1 is characterized in that pharmaceutical composition composition parts by weight are:
Herba Ephedrae 5-15 part Rhizoma Corydalis 5-15 part Semen Sinapis Albae 5-25 part Semen Armeniacae Amarum 5-15 part Rhizoma Zingiberis Recens is formed 5-20 part.
3, Chinese medicine composition plaster according to claim 1 is characterized in that pharmaceutical composition composition parts by weight are:
10 parts in 10 portions of Rhizoma Zingiberis Recenss of 10 portions of Semen Armeniacae Amarums of 10 parts of Semen Sinapis Albaes of 10 parts of Rhizoma Corydalis of Herba Ephedrae.
4, the preparation method of Chinese medicine composition plaster according to claim 1, Herba Ephedrae, Rhizoma Corydalis, Semen Sinapis, Semen Armeniacae Amarum, Rhizoma Zingiberis Recens powder are broken into coarse powder, water or aquiferous ethanol extract, filtering, being condensed into relative density is 1.2-1.5 (40-80 ℃), is preferably the extractum of 1.2-1.3 (40-80 ℃); With the ethanol precipitation of gained extractum with 50-80%, the filtering precipitation, supernatant concentration becomes 1.2-1.5 (40-80 ℃), and the extractum that is preferably 1.2-1.3 (40-80 ℃) is with carbomer, polyvinyl alcohol its abundant swelling that makes soluble in water, add the described clear paste of claim 4, stirring is the A phase; Gelatin, glycerol and an amount of propylene glycol and ethanol are dissolved each other, add sodium polyacrylate under the stirring at low speed respectively, the back that stirs is as the B phase, and Kaolin is dissolved in the water as C mutually with transdermal enhancer.Stirring condition mixes C with B earlier down mutually mutually, adds the A phase then, stirs, and coats on the non-woven fabrics, smokes, and covers anti-glutinous layer, promptly.
5, method according to claim 4 is characterized in that described extractum Chinese medicine active component includes (weight ratio): ephedrine 5-100 part, pseudoephedrine 2-50 part, Rhizoma Corydalis second 1-80 part, the plain 1-100 part of Rhizoma Corydalis first, sinalbin 0.01-150 part, amygdaloside 10-300 part, sinapic acid choline ester. 0.01-230 part, zingiberol 0.1-100 part, zingiberene 0.2-150 part.
6, method according to claim 7 is characterized in that the thing active component includes (weight ratio) in the described extractum:
Ephedrine 50-300 part pseudoephedrine 50-350 part tetrahydropalmatine 1-30 part
The plain 0.01-200 part of Rhizoma Corydalis first sinalbin 0.01-150 part amygdaloside 50-500 part
Sinapic acid choline ester. 0.1-50 part zingiberol 0.1-50 part zingiberene 0.2-50 part.
7, method according to claim 7 is characterized in that the thing active component includes (weight ratio) in the described extractum:
5 parts of 5 parts of zingiberols of 300 parts of sinapic acid choline ester .s of 5 parts of amygdalosides of 100 parts of tetrahydropalmatines of ephedrine.
8, according to claim 1 or 6 described Chinese medicine composition plaster, it is characterized in that blank substrate comprises (weight ratio):
Carbomer 2-10 part, sodium polyacrylate 2-10 part, polyvinyl alcohol 10-15 part, gelatin 5-20 part, Kaolin 3-10 part glycerol 10-30 part, water are an amount of.
9, according to claim 1 or 6 described Chinese medicine composition plaster, it is characterized in that blank substrate (weight ratio):
5 parts of carbomers, 7 parts of sodium polyacrylates, 10 parts of polyvinyl alcohols, 8 parts in gelatin, 3 parts of Kaolin, 20 parts of glycerol.
10, according to claim 1 or 6 described Chinese medicine composition plaster, the weight ratio that it is characterized in that active constituents of medicine and transdermal enhancer is 50-100: 1, and transdermal enhancer is selected from one or more mixture in Mentholum, Borneolum Syntheticum, the Oleum Caryophylli.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104208637A (en) * | 2014-09-18 | 2014-12-17 | 北京中医药大学 | Novel application of external traditional Chinese medicine composition |
| CN105963452A (en) * | 2016-06-24 | 2016-09-28 | 南阳医学高等专科学校第附属医院 | Traditional Chinese medicine patch for treating infantile cold cough and preparation method thereof |
| CN104174007B (en) * | 2014-09-18 | 2018-05-08 | 北京中医药大学 | A kind of Traditional Chinese medicinal composition plaster agent for treating asthma |
| CN108815330A (en) * | 2018-08-03 | 2018-11-16 | 顾倍宁 | A kind of Chinese medicine for treating asthma |
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2006
- 2006-06-22 CN CN 200610086865 patent/CN101091786A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208637A (en) * | 2014-09-18 | 2014-12-17 | 北京中医药大学 | Novel application of external traditional Chinese medicine composition |
| CN104208637B (en) * | 2014-09-18 | 2017-07-11 | 北京中医药大学 | A kind of new application of external medicine composition |
| CN104174007B (en) * | 2014-09-18 | 2018-05-08 | 北京中医药大学 | A kind of Traditional Chinese medicinal composition plaster agent for treating asthma |
| CN105963452A (en) * | 2016-06-24 | 2016-09-28 | 南阳医学高等专科学校第附属医院 | Traditional Chinese medicine patch for treating infantile cold cough and preparation method thereof |
| CN108815330A (en) * | 2018-08-03 | 2018-11-16 | 顾倍宁 | A kind of Chinese medicine for treating asthma |
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