CN103463520A - Qi moving and bowel relaxing plaster and preparation method thereof - Google Patents
Qi moving and bowel relaxing plaster and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a qi moving and bowel relaxing plaster and preparation method thereof, and the traditional Chinese medicine extract product formula is composed of 25-40% of rheum officinale, 10-15% of immature orange fruits, 10-15% of magnolia cortex, 10-15% of fleece-flower root, 5-10% of peach seeds, 5-10% of hemp fruits, 10-15% of minor element-rich malt, 8-12% of licorice and 5-10% of mint. The preparation method comprises the following steps: extracting traditional Chinese medicinal material extracts, adding purchased cataplasm matrix into the extracted extracts, stirring and mixing well, coating, dividing and cutting, and packing. The qi moving and bowel relaxing plaster provided by the invention has the advantages of long-acting drug release and effective slow release; the qi moving and bowel relaxing plaster is used for moving qi and relaxing bowel, and is used for treating habitual constipation, distention of qi in intestine after operation, abdominal distension and other diseases. The invention has the characteristics of rapid effect, low allergy rate, convenient usage, etc.
Description
Technical field
The invention belongs to the preparation method of a kind of Chinese herbs paste and its use substrate, particularly a kind of circulation of qi promoting relieving constipation subsides of the diseases such as constipation, postoperative intestinal tympanites, de-distention and fullness in the abdomen and preparation method of substrate for the treatment of.
Background technology
Emplastrum means medicine dissolution or is mixed in natural or synthesized polymer material substrate, spreads onto on the material of mounting, and for sticking the exterior-applied formulation in skin, the emplastrum that the water-soluble high-molecular material of wherein take is substrate is called cataplasma.Cataplasma is a kind of external patch unguentum, in Japan, applicating history more of a specified duration is arranged.Be medicinal substances extract, medical material or/and chemicals with after suitable hydrophilic matrix mixes, be coated on the emplastrum of making on back lining materials, formed by backing (non-woven fabrics commonly used, stretch fabric), mastic, anti-mucosa (isolating membrane on mastic surface).Its drug loading is large, and moisture retention is strong, good, ageing-resistant with the compatibility of skin; Can repeatedly take off subsides, stop administration at any time; Dosage is accurate, and the blood drug level balance, without peak valley phenomenon, can reduce toxic and side effects; Pollute without organic solvent in commercial production, meet environmental requirement.
Traditional black plaster is decocted with vegetable oil Chinese crude drug exactly under high-temperature condition, add again Plumbum preparatium after certain degree, to " dripping into pearl " shape, and then cooling, beach is on cotton or kraft paper, during use, must heat with slow fire, this dosage form is in China's history of existing several thousand, from among the people to regular, this technique of pharmaceutical factory and dosage form are also being used, but perfect along with the development of medical sci-tech and various detection meanss, this dosage form is eliminated gradually, its deficiency have following some: 1) heavy metals exceeding standard, Plumbum preparatium itself is poisonous: 2) high temperature process is destroyed medicament effective component, 3) heat stream oil pollution is serious, 4) technique and technology are difficult to reach national GMP standard.
The rubber plaster patch selects chemical industry to synthesize colloid exactly, by after Chinese medicine powder or water medicine powder and colloid mixing, is coated on cotton or stretch fabric, more attached one deck Concha Arcae film or separate paper.Due to the restriction of the technique of this dosage form own, can only play the purpose of temporary transient pain relieving.Also be eliminated now.It can not conclude some completely: 1) owing to selecting chemical glue as substrate, although it is still very high to solve the ventilative poor irritated rate of problem by punching.2) medicament contg is low, and coating only has 0.1mm, mostly only by adding Western medicine pain relieving composition, carrys out the temporary transient analgesic effect that plays; 3) the colloid molecular structure is tight, and in pharmaceutical pack is rolled in, medicament effective component can't permeate at all, can only play the effect of sealing; 4) adopt gasoline etc. as solvent, processing is that danger has again pollution.
Room temperature pressure sensitive adhesive plaster, its technique is by after micro-powder of Chinese herbs, is added in the room temperature pressure sensitive adhesive and stirs, by the technique that is similar to industrial gummed tape, equally coat on spun laced fabric or non-woven fabrics, then select above separate paper is attached to, because production cost is low, can quantize again, outward appearance is good-looking again, adopted by a lot of producers, compare with rubber plaster, just make progress on processing technology and standby material, just focus on its surface, but do not tackle the problem at its root.This dosage form is from following several deficiencies: 1) medicament contg is low, the super only 0.1mm of coating the same as rubber plaster; 2) play temporary transient analgesic effect by adding western medicine composition; 3) the bad control of viscosity, be not that not glue be exactly to take off to get off, unstable.
A kind of dosage form come into vogue on market about calendar year 2001, this dosage form is to select the PUR of fusing point about 135 degree as carrying platform, concrete technology is after first PUR being dissolved with naked light or electrical heating, add again Chinese medicine powder or western medicine composition, with industrial PUR flush coater or blade coating on non-woven fabrics or spun laced fabric, be cut into lamellar with itemize microtome or die-cutting machine again after rolling, use the spraying of industrial coating machine by fourth, the plaster surfacing is smooth, coating can be thickeied again, add again the cooling rear high resilience of PUR, claim in the industry its " false bar cloth ", by domestic a lot of producer, praised highly.But the angle that is placed on percutaneous dosing is said, also has the following disadvantages: 1) the colloid molecular structure is tight, and Chinese medicine can't permeate at all, just relies on western medicine composition to make temporary transient analgesic effect.2) sensation high resilience, but be to there is moisture-keeping functions anything but, just by the coating layer thickness thickening, do not have moisturizing and control slow releasing function at all.
Gel rubber plaster adopts a kind of water-base resin rubber powder exactly, dissolve in water, then add chemical drugs or Chinese medicine extract, as defervescence plaster used as the Japan of seeing on the market, the cold bar cream of Korea S adopts this dosage form exactly, this dosage form has approached real cataplasma, but basic internal structure and plastic property comprise that the adherence force aspect is not good enough, owing to selecting water-base cement, human body just dissolves or comes off after sticking perspiration, and patches matrix layer all mummification again after moisture evaporation, without humidity-preserving type.
The wax plaster is that a kind of Cera Flava or industrial wax oil are substrate, in medicated powder is stirred in, with oodle maker, is pressed into lamellar, become required specification with the knife plate rolling cut, the slow fire heating must be arranged during use, bad but proportioning is controlled, stiff dry and cracked phenomenon mostly occurs, be referred to as in the industry " false black plaster ".Waste lamp oil by not sleeping at night and receive the lost of red technique along with tradition, this technique can only be selected by a lot of producers.But all do not reach the requirement of transdermal administration from the patch state to the Transdermal absorption effect.
The soak patch is exactly to use the filling machine fill in 5 milliliters to 20 milliliters plastics or aluminium foil bag liquid medicine, then a thick spun laced fabric or the cotton of sucking blood are fixed on to the standby cloth of plaster central authorities, by the liquid medicine painting, carry out moistening in the above, then sticking on human body uses, this dosage form also has the history of more than one thousand years in China, just the processing technique difference, bother and be not suitable for large-scale production owing to using, just at clinical orthopaedics, use often, the market circulation link is general.
It is that Chinese medicinal powder and iron powder, active carbon are mixed that this dosage form is pasted in hot moxibustion, add oxidant and then with the packer package encapsulation, become packed, during use, unpack, produce oxidation reaction with air, thereby reach the effect of thermotherapy and medication, rheumatic osteopathia is had to certain curative effect, but to other symptom DeGrains.
Be more than to the traditional plaster of China and novel dosage form, be introduced and analyze, differ from one another, but have certain shortcoming, be in particular in: the aspect Shortcomings such as anaphylaxis, content of dispersion, transdermal absorption factor, sticking strength, control slow release.
The object of the present invention is to provide a kind of patch product---circulation of qi promoting relieving constipation subsides and preparation method, take water-soluble high-molecular material as main matrix, add medicine, the technique such as close, be coated with, cut through refining and make external preparation, clinical practice is in diseases such as habitual constipation, wrist distention and fullness in the abdomen, postoperative intestinal tympaniteses.Polymer-based material in patch prepared by this method can absorb and carry the Chinese medicine extract that comprises multiple water solublity and liposoluble constituent better, and can be fast, the effective ingredient that comprises in transdermal release substrate enduringly.
Summary of the invention
Qi-invigorating constipation-relieving of the present invention, by medicinal substances extract or chemicals and suitable substrate, formed, the medicinal material extract composition formula that is it is by Radix Et Rhizoma Rhei 35: Fructus Aurantii Immaturus 12: Cortex Magnoliae Officinalis 13: Radix Polygoni Multiflori 13: Semen Persicae 8: Urtica cannabina L. 10: rich micro-Fructus Hordei Germinatus 12: Radix Glycyrrhizae 10:, Herba Menthae 8 (weight ratio) forms, take water-soluble high-molecular material as main matrix, add drug extract, through refining close, be coated with, cut, the package handling operation makes external preparation circulation of qi promoting relieving constipation and pastes.Above-mentioned circulation of qi promoting relieving constipation is pasted, and the best medical material formula that is it is by Radix Et Rhizoma Rhei 35: Fructus Aurantii Immaturus 12: Cortex Magnoliae Officinalis 13: Radix Polygoni Multiflori 13: Semen Persicae 8: Urtica cannabina L. 10: rich micro-Fructus Hordei Germinatus 12: Radix Glycyrrhizae 10: Herba Menthae 8 (weight ratio) forms.
Above-mentioned qi-invigorating constipation-relieving is purchased from Tianjin Rui Kangbabu medicine bioengineering Science and Technology Ltd.
The preparation method of above-mentioned qi-invigorating constipation-relieving, so preparation method is being divided into:
1) Chinese crude drug extractum extraction process
Above-mentioned medical material process is selected, after weighing, according to aforementioned proportion, mix, be crushed to 10 order coarse powder, pack in rustless steel container, after adding for the first time alcohol dipping 5-10 hour of 75-90% of 2.0-2.5 times of medical material, then the medical material after infiltrating is proceeded in the stainless steel seepage bucket, add 75-90% alcohol dipping 50-55h, the ethanol of the 75-90% doubly measured with the 4-5 of medical material successively, the ethanol of the 65%-85% that 3-4 doubly measures, the ethanol of the 50-75% that 4-5 doubly measures is with every kilogram of medical material 1.8ml/min flow velocity seepage flow, absorb concentration tank with spherical decompression and reclaim ethanol, merging filtrate is concentrated into the clear paste that relative density is 1.3-1.35 (40 ℃-67 ℃), the ethanol reclaimed saves backup, after finally 250 orders-300 mesh filter screen for extractum being filtered, the extractum the obtained seal of vessel of packing into is stand-by,
2) qi-invigorating constipation-relieving preparation, mixing
The catablasm base material of purchase is added to above-mentioned standby extractum, with the 1000-1200rpm rotating speed, stir 15-20min, obtain invented qi-invigorating constipation-relieving, then form by being coated with, cutting, packing.
Below introduce circulation of qi promoting relieving constipation subsides Chinese medicine extract and comprise Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Radix Polygoni Multiflori, Semen Persicae, Urtica cannabina L., rich micro-Fructus Hordei Germinatus, Radix Glycyrrhizae and nine kinds of medical materials of Herba Menthae: Radix Et Rhizoma Rhei 25%-40%, Fructus Aurantii Immaturus 10%-15%, Cortex Magnoliae Officinalis 10%-15%, Radix Polygoni Multiflori 10%-15%, Semen Persicae 5%-10%, Urtica cannabina L. 5%-10%, rich micro-Fructus Hordei Germinatus 10%-15%, Radix Glycyrrhizae 8%-12%, Herba Menthae 5-10%.
Radix Et Rhizoma Rhei: another name, general, Huang Liang, fire ginseng, skin are as, Shu Huohuang.There is purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation.For the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle is treated skin ulcer, blood stasis amenorrhea, injury from falling down.Nature and flavor: bitter, cold.Function cures mainly: the poison that purges heat, removing mass is stagnant, blood stasis expelling blood.The constipation of smelting excess-heat, food stagnation feeling of fullness etc.
Fructus Aurantii Immaturus: another name, goose eye Fructus Aurantii Immaturus.Meridian distribution of property and flavor: hardship: suffering; Cold.Return spleen; Stomach; Liver; Heart channel.Effect: stop in stagnant; Feeling of fullness distending pain: constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.
Cortex Magnoliae Officinalis: nature and flavor: hardship; Hot; Warm in nature.Gui Jing: spleen channel; The stomach warp; Large intestine channel.Function: circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, the gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest is breathed with cough
Radix Polygoni Multiflori: another name, honey is fragrant, blue or green Radix Polygoni Multiflori, wide Radix Polygoni Multiflori etc.Root for feverfew cloud Radix Polygoni Multiflori, Yuexi Radix Polygoni Multiflori, river Radix Polygoni Multiflori etc.Perennial herb, root is sturdy, the high 30-200cm of stem left and right.Nature and flavor: arduous, warm.Function cures mainly: promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.The smelting invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, vomiting etc.
Semen Persicae: have another name called white Semen Persicae, Bin Men, Fructus Canarii albi, semen arecae etc.For palm fibre is put the seed of section's plant Semen Persicae, the Semen Persicae tree be for more than Qiao Gaodu can reach 10-18 rice, branch not, and leaf falls behind the obvious ring grain of formation.Mainly be distributed in the ground such as Yunnan, Guangdong, Taiwan, Guangxi.Nature and flavor: toil, temperature.Excessive Semen Persicae alkali causes sialorrhea, vomiting, diuresis, lethargy and convulsions.Function cures mainly: parasite killing, removing mass, the therapeutic method to keep the adverse QI flowing downwards, Hang Shui.Control malnutrition due to parasitic infestation, dyspepsia, institute's abdominal distention and pain etc.
Urtica cannabina L.: another name, Radix Angelicae Sinensis, cloud are returned, western Urtica cannabina L., Min Urtica cannabina L. etc.Root for the samphire Urtica cannabina L..Perennial herb, the high 40-100cm of stem left and right.Nature and flavor: Gan Xin, temperature.Function cures mainly: benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation.Control menoxenia, amenorrhea stomachache, dryness of the intestine dyschezia, tumor addiction knot poly-etc.
Rich micro-Fructus Hordei Germinatus: rich micro-Fructus Hordei Germinatus is rich in chromium, manganese, zinc, four kinds of trace element of selenium, than the content in common Fructus Hordei Germinatus, exceeds 10-20 doubly, and trace element has important effect in regulating gastrointestinal function, Fructus Hordei Germinatus, and slightly warm in nature, return spleen, stomach, Liver Channel.The energy digesting and appetizing, and in.For food stagnation, depression of liver-QI, the treatment of the diseases such as incoordination between the liver and stomach.
Radix Glycyrrhizae: sweet in the mouth, property is flat, nontoxic.Treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Give birth to and use pathogenic fire purging heat, the ripe use exterior cold of fall apart, go pharyngalgia, remove pathogenic heat, delay healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.
Herba Menthae: cool in nature, the sweet in the mouth suffering, be a kind of Chinese medicine commonly used, is of value to the treatment accumulation of food in the stomach and intes tine due to indigestion, removes the gastral cavilty stagnant sensation that rises.But also cure hiccup and spastic stomachache.In addition, Herba Menthae also has wind dispelling effect preferably in intestinal, can alleviate the intestinal inflation, speed to delay the myenteron wriggling, has the effect that slows down the enterocele pain; Research shows, Herba Menthae can significantly promote the Drug Percutaneous Absorption effect, and the effect of this promotion Transdermal absorption may be the transdermal penetration ability of the structural change medicine by changing Stratum corneum lipids due to menthol.
The specific embodiment
Embodiment 1: the extraction of Chinese crude drug extractum
(1) Chinese medicine weighing: Radix Et Rhizoma Rhei 350g, Fructus Aurantii Immaturus 120g, Cortex Magnoliae Officinalis 130g, Radix Polygoni Multiflori 130g, Semen Persicae 80g, Urtica cannabina L. 100g, rich micro-Fructus Hordei Germinatus 120g, Radix Glycyrrhizae 100g, Herba Menthae 80g.
(2) above-mentioned medical material process is selected, after weighing, according to aforementioned proportion, mix, be crushed to 10 order coarse powder, pack in rustless steel container, after adding for the first time alcohol dipping 5-10 hour of 75-90% of 2.0-2.5 times of medical material, then the medical material after infiltrating is proceeded in the stainless steel seepage bucket, add 75-90% alcohol dipping 50-55h, the ethanol of the 75-90% doubly measured with the 4-5 of medical material successively, the ethanol of the 65%-85% that 3-4 doubly measures, the ethanol of the 50-75% that 4-5 doubly measures is with every kilogram of medical material 1.8ml/min flow velocity seepage flow, absorb concentration tank with spherical decompression and reclaim ethanol, merging filtrate is concentrated into the clear paste that relative density is 1.3-1.35 (40 ℃-67 ℃), the ethanol reclaimed saves backup, after finally 250 orders-300 mesh filter screen for extractum being filtered, the extractum the obtained seal of vessel of packing into is stand-by,
Embodiment 2: the preparation that the circulation of qi promoting relieving constipation is pasted
The catablasm base material 8kg of purchase is added to above-mentioned standby extractum, with the 1000-1200rpm rotating speed, stir 15-20min, by being coated with, cutting, packing, both obtain circulation of qi promoting relieving constipation subsides.
Circulation of qi promoting relieving constipation plaster formula is that natural Chinese medicines is extracted, and compatibility is reasonable, the prescription science, and treatment is parallel with conditioning, has no side effect; Technique advanced person, extracts active ingredients is thorough, guarantees curative effect; Easy to use, safe and effective, non-stimulated, without irritated.The external use plaster be prepared into, improved preparation level, the blood drug level that causes because of oral medication is unbalanced, dosage is large, non-targeted organ absorbs side effect and interference and the stimulation of gastrointestinal have been avoided, because of the absorption of medicine not by the first-pass effect of gastrointestinal and liver, reduced the loss of pharmaceutical compositions, active ingredient is more stable enters blood flow, makes blood level be stabilized in valid density, and then retains and improved drug effect.
Claims (3)
1. a circulation of qi promoting relieving constipation is pasted, by Chinese medicine extract and suitable substrate, formed, it is characterized in that the Chinese medicine extraction composition formula by: Radix Et Rhizoma Rhei 25%-40%, Fructus Aurantii Immaturus 10%-15%, Cortex Magnoliae Officinalis 10%-15%, Radix Polygoni Multiflori 10%-15%, Semen Persicae 5%-10%, Urtica cannabina L. 5%-10%, rich micro-Fructus Hordei Germinatus 10%-15%, Radix Glycyrrhizae 8%-12%, Herba Menthae 5-10% form, take water-soluble high-molecular material as main matrix, add Chinese medicine extract, through refining, close, be coated with, cut, pack and form.
2. circulation of qi promoting relieving constipation according to claim 1 is pasted, and the best medical material formula that it is characterized in that it is by Radix Et Rhizoma Rhei 35: Fructus Aurantii Immaturus 12: Cortex Magnoliae Officinalis 13: Radix Polygoni Multiflori 13: Semen Persicae 8: Urtica cannabina L. 10: rich micro-Fructus Hordei Germinatus 12: Radix Glycyrrhizae 10: Herba Menthae 8 (weight ratio) forms.
3. the preparation method of qi-invigorating constipation-relieving according to claim 1 it is characterized in that preparation method is divided into:
1) Chinese crude drug extractum extraction process
Above-mentioned medical material process is selected, after weighing, according to aforementioned proportion, mix, be crushed to 10 order coarse powder, pack in rustless steel container, after adding for the first time alcohol dipping 5-10 hour of 75-90% of 2.0-2.5 times of medical material, then the medical material after infiltrating is proceeded in the stainless steel seepage bucket, add 75-90% alcohol dipping 50-55h, the ethanol of the 75-90% doubly measured with the 4-5 of medical material successively, the ethanol of the 65%-85% that 3-4 doubly measures, the ethanol of the 50-75% that 4-5 doubly measures is with every kilogram of medical material 1.8ml/min flow velocity seepage flow, absorb concentration tank with spherical decompression and reclaim ethanol, merging filtrate is concentrated into the clear paste that relative density is 1.3-1.35 (40 ℃-67 ℃), the ethanol reclaimed saves backup, after finally 250 orders-300 mesh filter screen for extractum being filtered, the extractum the obtained seal of vessel of packing into is stand-by,
2) qi-invigorating constipation-relieving preparation
The catablasm base material of purchase is added to above-mentioned standby extractum, with the 1000-1200rpm rotating speed, stir 15-20min, obtain invented qi-invigorating constipation-relieving, then form by being coated with, cutting, packing.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104055629A (en) * | 2014-06-24 | 2014-09-24 | 凌中鑫 | Qi-circulation-promoting and bowel-relaxing postoperative physiotherapy belt and preparing method of Qi-circulation-promoting and bowel-relaxing postoperative physiotherapy belt |
| CN104069224A (en) * | 2014-06-24 | 2014-10-01 | 凌中鑫 | Plaster for promoting qi and relaxing bowels and preparation method of plaster |
| CN104127788A (en) * | 2014-07-16 | 2014-11-05 | 太仓思瑞生物科技有限公司 | Use of external traditional Chinese medicine for improving constipation |
| CN104127787A (en) * | 2014-07-16 | 2014-11-05 | 太仓思瑞生物科技有限公司 | Traditional Chinese medicinal plaster for treating constipations |
| CN104189667A (en) * | 2014-07-22 | 2014-12-10 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition for preventing or treating tumor complication constipation |
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| CN102784221A (en) * | 2012-08-29 | 2012-11-21 | 苏州大学附属第一医院 | Traditional Chinese medicine composition for treating constipation and preparation method and clinical preparation thereof |
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| CN102784221A (en) * | 2012-08-29 | 2012-11-21 | 苏州大学附属第一医院 | Traditional Chinese medicine composition for treating constipation and preparation method and clinical preparation thereof |
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| 许山鹰: "便秘的中医药疗法", 《中国临床医生》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055629A (en) * | 2014-06-24 | 2014-09-24 | 凌中鑫 | Qi-circulation-promoting and bowel-relaxing postoperative physiotherapy belt and preparing method of Qi-circulation-promoting and bowel-relaxing postoperative physiotherapy belt |
| CN104069224A (en) * | 2014-06-24 | 2014-10-01 | 凌中鑫 | Plaster for promoting qi and relaxing bowels and preparation method of plaster |
| CN104127788A (en) * | 2014-07-16 | 2014-11-05 | 太仓思瑞生物科技有限公司 | Use of external traditional Chinese medicine for improving constipation |
| CN104127787A (en) * | 2014-07-16 | 2014-11-05 | 太仓思瑞生物科技有限公司 | Traditional Chinese medicinal plaster for treating constipations |
| CN104189667A (en) * | 2014-07-22 | 2014-12-10 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition for preventing or treating tumor complication constipation |
| CN104189667B (en) * | 2014-07-22 | 2017-08-25 | 首都医科大学附属北京中医医院 | Chinese medicine composition for preventing or treating tumor complication constipation |
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Application publication date: 20131225 |