CN104173264B - Rose essence oil hydrogel patch and preparation method thereof - Google Patents
Rose essence oil hydrogel patch and preparation method thereof Download PDFInfo
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- CN104173264B CN104173264B CN201410344541.6A CN201410344541A CN104173264B CN 104173264 B CN104173264 B CN 104173264B CN 201410344541 A CN201410344541 A CN 201410344541A CN 104173264 B CN104173264 B CN 104173264B
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Abstract
The invention discloses a rose essence oil hydrogel patch comprising a carrier and a traditional Chinese medicine ointment, wherein the traditional Chinese medicine ointment is prepared from the following raw materials: semen cassiae, peach blossom, persimmon leaves, bighead atractylodes rhizome, radix ampelopsis, oldenlandia diffusa, blackend swallowwort root, white poria, folium eriobotryae, scutellaria baicalensis, liquorice, fourstamen stephania root and rose essence oil; the carrier is hydrogel; the traditional Chinese medicine ointment is prepared by adding water into the raw materials of the traditional Chinese medicine ointment, decocting, filtering and concentrating into a paste; and then the traditional Chinese medicine ointment is mixed with the hydrogel, so as to finally prepare the rose essence oil hydrogel patch which is safe, small in side effect, good in transdermal absorption ratio and obvious in whitening effect.
Description
Technical field
The present invention relates to skin care applications, and in particular to Flos Rosae Rugosae quintessence oil hydrogel plaster and preparation method thereof.
Background technology
In the aesthetical standard of world today's main flow, it is a wherein important ring, particularly Asia that skin is fair and clear.As the saying goes,
One white screening hundred is ugly, it is sufficient to illustrate the importance of whitening;Therefore, almost all of Asia women all attaches great importance to the white of oneself skin
Only.
Popular many whitening products, such as concealer, foundation cream, loose powder, muffin currently on the market, but these products are all only
It is to take stopgap measures, does not effect a permanent cure.
China's traditional medicine, for whitening have uniqueness opinion, can fundamentally skin whitening, compared with doctor trained in Western medicine,
Side effect is minimum.
Number of patent application is the patent of invention of CN 201310710159.8, discloses a kind of traditional Chinese medicinal whitening mask, and it is by
The mixture of medicine composition, additive, ceramide, guar gum and chitosan and pure water are constituted, and its constituent mass percentage ratio is:
The mixture 1.5 of Chinese medicine ingredients 8~15%, additive 5~12%, Cer EOS 0~23%, guar gum and chitosan~
4%, balance of pure water;Wherein, Chinese medicine ingredients are the mixture of the Radix Angelicae Dahuricae, Rhizoma Typhonii, Poria, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Semen Armeniacae Amarum powder;Addition
Agent is the mixture of orange blossom and Rosehips oil.Although the patent of invention it uses cosmetics with certain whitening effect
The banned substance Radix Angelicae Dahuricae;Simultaneously as Chinese medicinal ingredients are effective slow, the patent of invention does not also overcome this shortcoming.
Number of patent application is the patent of invention of CN201310092150.5, discloses a kind of Chinese medicine whitening and freckle-removing liquid, by weight
Amount number, it is by 8~13 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae), 8~13 parts of Herba Leonuri, 7~10 parts of Radix Angelicae Sinensis, 7~10 parts of Semen Persicae, 8~13 parts of Poria, white
It is 8~13 parts of liana, 8~10 parts of the Radix Angelicae Dahuricae, 8~10 parts of the Rhizoma Atractylodis Macrocephalae, 7~10 parts of Radix Glycyrrhizae, 8~13 parts of Bombyx Batryticatus, 8~13 parts of Bulbus Fritillariae Thunbergii, white
8~13 parts of Radix Aconiti Lateralis Preparata, 7~10 parts of Radix Cynanchi Paniculati, 8~13 parts of Margarita powder, 7~10 parts of Radix Isatidis, 8~13 parts of Fructus Forsythiae, Lithargyrum 5~8
Part, 2~5 parts of Propylene Glycol, 100~150 parts of glycerol, 250~400 parts of pure water.The patent of invention is due in the same of skin whitening
When, it is also contemplated that speckle dispelling, the whitening effect for causing the patent of invention is not fine;Simultaneously as the patent of invention is liquid
Body, when using the product, after liquid dried, a large amount of medicinal active ingredients remain in the surface of skin, pharmacologic action time
It is short, it is impossible to be absorbed by human body well, medicinal active ingredient is wasted significantly.
Therefore, it is anxious it is yet-to-be developed go out one kind use safe ready, Small side effects, whitening effect substantially and medicinal component is made
With the whitening product of time length.
The content of the invention
For above the deficiencies in the prior art, the invention provides a kind of whitening effect substantially, medicinal component action time
Long and Flos Rosae Rugosae quintessence oil hydrogel plaster of Small side effects and preparation method thereof.
The technical solution used in the present invention is Flos Rosae Rugosae quintessence oil hydrogel plaster, is made up of carrier and Chinese medicine ointment, it is described in
Medicine ointment is made up of following raw material and its parts by weight:The weight portion of Semen Cassiae 10~100, the weight portion of Flos persicae 10~100, Folium Kaki
It is 10~100 weight portions, the weight portion of the Rhizoma Atractylodis Macrocephalae 10~100, the weight portion of Radix Ampelopsis 10~100, the weight portion of Herba Hedyotidis Diffusae 10~100, white
The weight portion of common vetch 10~100, the weight portion of Poria 10~100, the weight portion of Folium Eriobotryae 10~100, the weight portion of Radix Scutellariae 2~20, Radix Glycyrrhizae 2
~20 weight portions, the weight portion of Radix Stephaniae Tetrandrae 2~20 and the weight portion of Flos Rosae Rugosae quintessence oil 4~24..
Preferably, the Chinese medicine ointment is made up of following raw material and its parts by weight:The weight portion of Semen Cassiae 40~60, Flos persicae
40~60 weight portions, the weight portion of Folium Kaki 40~60, the weight portion of the Rhizoma Atractylodis Macrocephalae 40~60, the weight portion of Radix Ampelopsis 50~70, Herba Hedyotidis Diffusae
50~70 weight portions, the weight portion of Radix Cynanchi Atrati 50~70, the weight portion of Poria 50~70, the weight portion of Folium Eriobotryae 50~70, Radix Scutellariae 8~12
Weight portion, the weight portion of Radix Glycyrrhizae 8~12, the weight portion of Radix Stephaniae Tetrandrae 8~12 and the weight portion of Flos Rosae Rugosae quintessence oil 10~14.
Preferably, in order to improve the transdermal absorption factor of the Flos Rosae Rugosae quintessence oil hydrogel plaster, the carrier is hydrogel.
Preferably, the hydrogel is made up of following raw material and its parts by weight:The weight portion of glycerol 60~600, polypropylene
The weight portion of sour sodium 15~150, the weight portion of ethylene glycol 5~50, the weight portion of polyvinylpyrrolidone 5~50, crosslinked polyethylene pyrroles
The weight portion of alkanone 1~10, the weight portion of xanthan gum 1~10, the weight portion of arbutin 1~10, the weight of Kojic Acid Dipalmitate 1~10
Part, the weight portion of aluminum glycinate 0.1~1, the weight portion of disodiumedetate 0.1~1, the weight portion of tartaric acid 0.1~1, sulphuric acid
The weight portion of aluminum 0.05~0.5, the weight portion of imidazoles hydroxyurea 0.05~0.5, the weight portion of methyl hydroxybenzoate 0.05~0.5, malic acid
0.05~0.5 weight portion and the weight portion of purified water 120~1200.
Preferably, the hydrogel is made up of following raw material and its parts by weight:The weight portion of glycerol 250~350, polypropylene
The weight portion of sour sodium 50~70, the weight portion of ethylene glycol 20~40, the weight portion of polyvinylpyrrolidone 20~40, crosslinked polyethylene pyrroles
It is the weight portion of alkanone 4~6, the weight portion of xanthan gum 4~6, the weight portion of arbutin 4~6, the weight portion of Kojic Acid Dipalmitate 4~6, sweet
The weight portion of propylhomoserin aluminum 0.4~0.6, the weight portion of disodiumedetate 0.5~0.7, the weight portion of tartaric acid 0.5~0.7, sulphuric acid
The weight portion of aluminum 0.2~0.4, the weight portion of imidazoles hydroxyurea 0.2~0.4, the weight portion of methyl hydroxybenzoate 0.1~0.3, malic acid 0.1~
0.3 weight portion and the weight portion of purified water 500~700.
A kind of preparation method of above-mentioned Flos Rosae Rugosae quintessence oil hydrogel plaster, comprises the steps:
A, Flos Rosae Rugosae is put in extractor, using carbon dioxide supercritical extraction is carried out, collected extract and obtain final product Flos Rosae Rugosae
Quintessence oil, it is stand-by;
B, by weight, weigh Chinese medicine ointment raw material Semen Cassiae, Flos persicae, Folium Kaki, the Rhizoma Atractylodis Macrocephalae, Radix Ampelopsis, Herba Hedyotidis Diffusae,
Radix Cynanchi Atrati, Poria, Folium Eriobotryae, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and the Flos Rosae Rugosae quintessence oil;Then the Chinese medicine ointment raw material is added water
Decoct, filter, be condensed into cream, obtain Chinese medicine ointment, it is stand-by;
C, by weight, weighs hydrogel raw materials glycerine, sodium polyacrylate, ethylene glycol, polyvinylpyrrolidone, crosslinking
Polyvinylpyrrolidone, xanthan gum, arbutin, Kojic Acid Dipalmitate, aluminum glycinate, disodiumedetate, tartaric acid,
Aluminum sulfate, imidazoles hydroxyurea, methyl hydroxybenzoate, malic acid and purified water;Then hydrogel raw material mixing is mixed thoroughly, obtains water-setting
Glue, it is stand-by;
D, the Chinese medicine ointment is mixed with the hydrogel, coated, section, solidification obtain final product Flos Rosae Rugosae quintessence oil hydrogel
Patch.
Preferably, in order that the Chinese medicine ointment is not separated after can mixing with the hydrogel, in step b,
The relative proportion of Chinese medicine ointment is 1.1~1.5.
Preferably, in order to exclude hydrogel in gas, in step c, when mixing is mixed thoroughly, the equipment of employing is water
Gel de-airing mixer;During mixing, pressure is 0.05~0.09Mpa, and temperature is 40~50 DEG C, and the time is 55~75min.
Preferably, in order that the medicinal active ingredient in the Flos Rosae Rugosae quintessence oil hydrogel plaster can be inhaled well by human body
Receive, in step d, mass ratio when Chinese medicine ointment mixes with hydrogel is 2~4: 17~23.
Semen Cassiae, with The flat liver of heat-clearing, blood fat-reducing blood pressure-decreasing, loosening bowel to relieve constipation, improving eyesight benefit eyeball the effect of.
Flos persicae, there is the effects such as invigorating blood circulation happy skin, drastic purgation diuresis, blood-activating analgetic, and the beautification function of Flos persicae is stemmed primarily from spending
Containing kaempferol, perfume (or spice), bean essence, trifolin and the nutrient substance such as vitamin A, B, C;These material energy expansion of blood vessels, dredge arteries and veins
Network, skin of moistening, improves blood circulation, promotes skin-nourishing and oxygen supply, and the lipofuscin element for making promotion human senility accelerates row
Let out, prevent melanin chronic deposition in skin, so as to effectively prevent chloasma, freckle, black speck, reach whitening and speckle dispelling
Effect.
Folium Kaki, containing appreciable protein, aminoacid and multivitamin outside, also containing higher than ordinary tea leaves it is several
Times even tens times of natural Vc, and the content of rutin, choline, flavonoid glycoside and 17 kinds of aminoacid needed by human also compares water
Fruits and vegetables, common beverages are high tens times;Natural Vc promotes human metabolism, has one to vitamin C deficiency, cardiovascular diseasess and cancer etc.
Constant current modulation is imitated;Rutin, choline play the role of vessel softening, prevent arteriosclerosis;Flavonoid glycoside can be reduced blood pressure, increase artery blood flow
Golden yellow staphylococcus are had obvious inhibitory action by amount.
The Rhizoma Atractylodis Macrocephalae, with spleen reinforcing, stomach reinforcing, dampness and in, it is antiabortive the effect of;Deficient QI of the spleen and stomach, anorexia, asthenia can be controlled few
Gas, deficiency-distension, have loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea it is uneasy;Also slow down aging, increasing
Effect of strong immunity, expansion of blood vessels, for the whitening of skin.
Radix Ampelopsis, the effect of with heat-clearing and toxic substances removing, removing obstruction for relieving pain, promoting tissue regeneration and ulcer healing;Main sore swollen toxin, scrofula, scald, eczema,
Pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula, leucorrhea, traumatic injury and traumatic hemorrhage etc..
Herba Hedyotidis Diffusae, the effect of with heat-clearing and toxic substances removing, XIAOFENG SAN gas, detumescent pain relieving, promoting urination to remove dampness, cures mainly lung-heat, intestinal
The disease such as heat, laryngalgia, sore swells.
Radix Cynanchi Atrati, the effect of with heat clearing away, removing heat from blood, diuresis, relieving restlessness tonifying YIN, cure mainly pathogenic warmth join the army, fever due to yin deficiency, puerperal it is cloudy
The disease such as void, dysphoria with smothery sensation vomiting, nephritis, pyretic stranguria, stranguria with blood.
Poria, has functions that eliminating dampness and diuresises, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, can control dysuria, oedema turgor, expectorant
Drink cough with dyspnea, vomiting, malignant histocytosis, have loose bowels, pass out semen, stranguria with turbid discharge, palpitation with fear, the disease such as forgetful.
Folium Eriobotryae, function removing heat from the lung and dissipating phlegm cough-relieving, stopping nausea and vomiting by lowering the adverse flow of QI cure mainly more than chronic cough, haematemesis, fever with chills, vomiting, diphtheria
Deng disease.
Radix Scutellariae, with heat clearing and damp drying, removing heat from blood be antiabortive, detoxicating functions, cure mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat,
The diseases such as neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle swells furuncle sore, baicalin have (1) antiinflammatory,
Antiallergic, antiallergic action, protection sclerotin;(2) antipyretic, removing toxic substances and antipathogen;(3) function of gallbladder promoting, liver protection and lipid-loweringing;(4) calm,
Blood pressure lowering, spasmolytic, diuresis, anticoagulant;(5) antioxidation, anti-cataract, anticancer.
Radix Glycyrrhizae, tool invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, the mitigation property of medicine, the work(of coordinating the actions of various ingredients in a prescription, Radix Glycyrrhizae agent has antiinflammatory
With the function of resistance state reflection;Radix Glycyrrhizae or enoxolone have desoxycortone class to act on;The flavone of Radix Glycyrrhizae have antiinflammatory, spasmolytic and
Antiacid effect.
Radix Stephaniae Tetrandrae, tetrandrine has antiallergic, and (tetrandrine is both an Anaphylactic mediator antagonist, is again one
Anaphylaxiss are had reliable antagonism and therapeutical effect by Anaphylactic mediator blocker), the effect such as resisting hypertension.
Flos Rosae Rugosae quintessence oil, with different physiological roles such as antiallergic sense, moisturizing, U.S. breast, elimination black eye, wrinkle, striae gravidarum, and
There is the Transdermal absorption for promoting active component.
Using above production technology, with Semen Cassiae, Flos persicae, Folium Kaki, the Rhizoma Atractylodis Macrocephalae, Radix Ampelopsis, Herba Hedyotidis Diffusae, Radix Cynanchi Atrati, BAIFU
Siberian cocklebur, Folium Eriobotryae, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and Flos Rosae Rugosae quintessence oil are the Chinese medicine ointment of raw material production, with obvious whitening effect,
Because what is utilized is the anti-inflammatory component of pure plant, its side effect is also minimum.Meanwhile, more than the Chinese medicine ointment and employing
After the hydrogel mixing of specific components and production technology production, obtained Flos Rosae Rugosae quintessence oil hydrogel plaster is inhaled with efficient transdermal
Yield so that medical active composition can in a large number enter human body so that whitening effect becomes apparent from;Meanwhile, not only reduce and orally draw
The side effect for rising, moreover it is possible to make part medical active composition not inactivate by the first pass effect of liver, so that active ingredient reaches
To higher bioavailability.
Specific embodiment
To make those skilled in the art understand the technique effect and its production technology of the present invention in detail, below specifically giving birth to
Produce example to be further described application and the technique effect of the present invention.
Embodiment 1
1st, the preparation of Flos Rosae Rugosae quintessence oil:
Flos Rosae Rugosae is put in extractor, using carbon dioxide supercritical extraction is carried out, collected extract and obtain final product rhodamine toner
Oil, it is stand-by.
2nd, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 100g, Flos persicae 100g, Folium Kaki 100g, Rhizoma Atractylodis Macrocephalae 100g, Radix Ampelopsis 100g, Herba Hedyotidis Diffusae 100g,
Flos Rosae Rugosae quintessence oil in Radix Cynanchi Atrati 100g, Poria 100g, Folium Eriobotryae 100g, Radix Scutellariae 20g, Radix Glycyrrhizae 20g, Radix Stephaniae Tetrandrae 20g and step 1
40g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 4400g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling
Rise, after boiling 3.5h is kept, filter at once;Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in plus
Water 4400g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, after boiling 3.5h is kept, filter at once;By gained filtering residue 2 again
Insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 4400g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, keeping
After boiling 3.5h, filter at once;Three gained filtrates are merged, is fitted in concentration tank and is concentrated, until its relative proportion is
1.2, obtain Chinese medicine ointment finished product 500g;Room temperature is cooled to, 5g ethanol is added, sealing preserve is carried out, it is stand-by.
3rd, the preparation of hydrogel:
Weigh glycerol 600g, sodium polyacrylate 150g, ethylene glycol 50g, polyvinylpyrrolidone 50g, crosslinked polyethylene pyrrole
Pyrrolidone 10g, xanthan gum 10g, arbutin 10g, Kojic Acid Dipalmitate 10g, aluminum glycinate 1g, disodiumedetate
1g, tartaric acid 1g, aluminum sulfate 0.5g, imidazoles hydroxyurea 0.5g, methyl hydroxybenzoate 0.5g, malic acid 0.5g and purified water 1200g, so
Afterwards mix homogeneously, then inserts in hydrogel de-airing mixer and stirs;Pressure is 0.05Mpa during stirring, and temperature is 30 DEG C,
After 50min, hydrogel 1920g is obtained, it is stand-by.
4th, the preparation of finished product:
The hydrogel 1920g and Chinese medicine ointment 202g are weighed, first uniform mixing, then inserts hydrogel microtome on foot
In, coating, section are placed 66 hours under room temperature, and solidification gets product Flos Rosae Rugosae quintessence oil hydrogel note, and then encapsulation is preserved.
Embodiment 2
1st, the preparation of Flos Rosae Rugosae quintessence oil:
Flos Rosae Rugosae is put in extractor, using carbon dioxide supercritical extraction is carried out, collected extract and obtain final product rhodamine toner
Oil, it is stand-by.
2nd, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 200g, Flos persicae 200g, Folium Kaki 170g, Rhizoma Atractylodis Macrocephalae 170g, Radix Ampelopsis 170g, Herba Hedyotidis Diffusae 170g,
Flos Rosae Rugosae quintessence oil in Radix Cynanchi Atrati 150g, Poria 150g, Folium Eriobotryae 150g, Radix Scutellariae 40g, Radix Glycyrrhizae 40g, Radix Stephaniae Tetrandrae 30g and step 1
80g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 8100g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling
Rise, after boiling 3.5h is kept, filter at once;Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in plus
Water 8100g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, after boiling 3.5h is kept, filter at once;By gained filtering residue 2 again
Insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 8100g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, keeping
After boiling 3.5h, filter at once;Three gained filtrates are merged, is fitted in concentration tank and is concentrated, until its relative proportion is
1.2, obtain Chinese medicine ointment finished product 800g;Room temperature is cooled to, 8g ethanol is added, sealing preserve is carried out, it is stand-by.
3rd, the preparation of hydrogel:
Weigh glycerol 1000g, sodium polyacrylate 300g, ethylene glycol 100g, polyvinylpyrrolidone 100g, crosslinked polyethylene
Ketopyrrolidine 20g, xanthan gum 20g, arbutin 15g, Kojic Acid Dipalmitate 15g, aluminum glycinate 2g, disodiumedetate
2g, tartaric acid 2g, aluminum sulfate 1g, imidazoles hydroxyurea 1g, methyl hydroxybenzoate 1g, malic acid 1g and purified water 3000g, then mix equal
It is even, then insert in hydrogel de-airing mixer and stir;Pressure is 0.05Mpa during stirring, and temperature is 30 DEG C, after 50min, obtains water
Gel 4600g, it is stand-by.
4th, the preparation of finished product:
The hydrogel 4600g and Chinese medicine ointment 460g are weighed, first uniform mixing, then inserts hydrogel microtome on foot
In, coating, section are placed 68 hours under room temperature, and solidification gets product Flos Rosae Rugosae quintessence oil hydrogel plaster, and then encapsulation is preserved.
Embodiment 3
1st, the preparation of Flos Rosae Rugosae quintessence oil:
Flos Rosae Rugosae is put in extractor, using carbon dioxide supercritical extraction is carried out, collected extract and obtain final product rhodamine toner
Oil, it is stand-by.
2nd, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 400g, Flos persicae 400g, Folium Kaki 400g, Rhizoma Atractylodis Macrocephalae 400g, Radix Ampelopsis 500g, Herba Hedyotidis Diffusae 500g,
Flos Rosae Rugosae quintessence oil in Radix Cynanchi Atrati 500g, Poria 500g, Folium Eriobotryae 500g, Radix Scutellariae 80g, Radix Glycyrrhizae 80g, Radix Stephaniae Tetrandrae 40g and step 1
100g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 18400g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling
Rise, after boiling 4.5h is kept, filter at once;Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in plus
Water 18400g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, after boiling 4h is kept, filter at once;Gained filtering residue 2 is put again
In entering to boil and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 18400g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, keeping boiling
After rising 3.5h, filter at once;Three gained filtrates are merged, is fitted in concentration tank and is concentrated, until its relative proportion is
1.3, obtain Chinese medicine ointment finished product 1800g;Room temperature is cooled to, 18g ethanol is added, sealing preserve is carried out, it is stand-by.
3rd, the preparation of hydrogel:
Weigh glycerol 2500g, sodium polyacrylate 500g, ethylene glycol 200g, polyvinylpyrrolidone 200g, crosslinked polyethylene
Ketopyrrolidine 40g, xanthan gum 40g, arbutin 40g, Kojic Acid Dipalmitate 40g, aluminum glycinate 4g, disodiumedetate
5g, tartaric acid 5g, aluminum sulfate 2g, imidazoles hydroxyurea 2g, methyl hydroxybenzoate 1g, malic acid 1g and purified water 5000g, then mix equal
It is even, then insert in hydrogel de-airing mixer and stir;Pressure is 0.06Mpa during stirring, and temperature is 38 DEG C, after 58min, obtains water
Gel 8000g, it is stand-by.
4th, the preparation of finished product:
The hydrogel 8000g and Chinese medicine ointment 1400g are weighed, first uniform mixing, then inserts hydrogel and cut into slices on foot
In machine, coating, section are placed 69 hours under room temperature, and solidification gets product Flos Rosae Rugosae quintessence oil hydrogel plaster, and then encapsulation is preserved.
Embodiment 4
1st, the preparation of Flos Rosae Rugosae quintessence oil:
Flos Rosae Rugosae is put in extractor, using carbon dioxide supercritical extraction is carried out, collected extract and obtain final product rhodamine toner
Oil, it is stand-by.
2nd, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 500g, Flos persicae 500g, Folium Kaki 500g, Rhizoma Atractylodis Macrocephalae 500g, Radix Ampelopsis 600g, Herba Hedyotidis Diffusae 600g,
Rhodamine toner in Radix Cynanchi Atrati 600g, Poria 600g, Folium Eriobotryae 600g, Radix Scutellariae 100g, Radix Glycyrrhizae 100g, Radix Stephaniae Tetrandrae 100g and step 1
Oily 120g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 26800g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution
Boiling, after boiling 5h is kept, filters at once;Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in plus
Water 26800g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, after boiling 4.5h is kept, filter at once;By gained filtering residue 2 again
Insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 26800g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, keeping
After boiling 3.5h, filter at once;Three gained filtrates are merged, is fitted in concentration tank and is concentrated, until its relative proportion is
1.3, obtain Chinese medicine ointment finished product 2680g;Room temperature is cooled to, 26.8g ethanol is reentered, sealing preserve is carried out, it is stand-by.
3rd, the preparation of hydrogel:
Weigh glycerol 3000g, sodium polyacrylate 600g, ethylene glycol 300g, PVPK30 0g, crosslinked polyethylene
Ketopyrrolidine 50g, xanthan gum 50g, arbutin 50g, Kojic Acid Dipalmitate 50g, aluminum glycinate 5g, disodiumedetate
6g, tartaric acid 6g, aluminum sulfate 3g, imidazoles hydroxyurea 3g, methyl hydroxybenzoate 2g, malic acid 2g and purified water 6000g, then mix equal
It is even, then insert in hydrogel de-airing mixer and stir;Pressure is 0.07Mpa during stirring, and temperature is 40 DEG C, after 55min, obtains water
Gel 9700g, it is stand-by.
4th, the preparation of finished product:
The hydrogel 9700g and Chinese medicine ointment 1455g are weighed, first uniform mixing, then inserts hydrogel and cut into slices on foot
In machine, coating, section are placed 70 hours under room temperature, and solidification gets product Flos Rosae Rugosae quintessence oil hydrogel plaster, and then encapsulation is preserved.
Embodiment 5
1st, the preparation of Flos Rosae Rugosae quintessence oil:
Flos Rosae Rugosae is put in extractor, using carbon dioxide supercritical extraction is carried out, collected extract and obtain final product rhodamine toner
Oil, it is stand-by.
2nd, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 600g, Flos persicae 600g, Folium Kaki 600g, Rhizoma Atractylodis Macrocephalae 600g, Radix Ampelopsis 700g, Herba Hedyotidis Diffusae 700g,
Rhodamine toner in Radix Cynanchi Atrati 700g, Poria 700g, Folium Eriobotryae 700g, Radix Scutellariae 120g, Radix Glycyrrhizae 120g, Radix Stephaniae Tetrandrae 120g and step 1
Oily 140g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 31000g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution
Boiling, after boiling 4h is kept, filters at once;Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in plus
Water 31000g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, after boiling 4h is kept, filter at once;Gained filtering residue 2 is put again
In entering to boil and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 31000g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, keeping boiling
After rising 4h, filter at once;Three gained filtrates are merged, is fitted in concentration tank and is concentrated, until its relative proportion is 1.3,
Obtain Chinese medicine ointment finished product 3050g;Room temperature is cooled to, 30.5g ethanol is added, sealing preserve is carried out, it is stand-by.
3rd, the preparation of hydrogel:
Weigh glycerol 3500g, sodium polyacrylate 700g, ethylene glycol 400g, PVP 0g, crosslinked polyethylene
Ketopyrrolidine 60g, xanthan gum 60g, arbutin 60g, Kojic Acid Dipalmitate 60g, aluminum glycinate 6g, disodiumedetate
7g, tartaric acid 7g, aluminum sulfate 4g, imidazoles hydroxyurea 4g, methyl hydroxybenzoate 3g, malic acid 3g and purified water 7000g, then mix equal
It is even, then insert in hydrogel de-airing mixer and stir;Pressure is 0.07Mpa during stirring, and temperature is 40 DEG C, after 60min, obtains water
Gel 11400g, it is stand-by.
4th, the preparation of finished product:
The hydrogel 11400g and Chinese medicine ointment 2400g are weighed, first uniform mixing, then inserts hydrogel and cut into slices on foot
In machine, coating, section are placed 70 hours under room temperature, and solidification gets product Flos Rosae Rugosae quintessence oil hydrogel plaster, and then encapsulation is preserved.
Embodiment 6
1st, the preparation of Flos Rosae Rugosae quintessence oil:
Flos Rosae Rugosae is put in extractor, using carbon dioxide supercritical extraction is carried out, collected extract and obtain final product rhodamine toner
Oil, it is stand-by.
2nd, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 800g, Flos persicae 800g, Folium Kaki 800g, Rhizoma Atractylodis Macrocephalae 800g, Radix Ampelopsis 900g, Herba Hedyotidis Diffusae 900g,
Rhodamine toner in Radix Cynanchi Atrati 900g, Poria 900g, Folium Eriobotryae 900g, Radix Scutellariae 150g, Radix Glycyrrhizae 150g, Radix Stephaniae Tetrandrae 150g and step 1
Oily 180g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 40000g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution
Boiling, after boiling 4.5h is kept, filters at once;Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then irrigated by lifting water to a higher level with a water pump, etc. toward described boiling
Add water 40000g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, after boiling 4h is kept, filter at once;By gained filtering residue 2 again
Insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 40000g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, keeping
After boiling 3.5h, filter at once;Three gained filtrates are merged, is fitted in concentration tank and is concentrated, until its relative proportion is
1.25, obtain Chinese medicine ointment finished product 4000g;Room temperature is cooled to, 40g ethanol is added, sealing preserve is carried out, it is stand-by.
3rd, the preparation of hydrogel:
Weigh glycerol 4500g, sodium polyacrylate 1100g, ethylene glycol 450g, polyvinylpyrrolidone 450g, the poly- second of crosslinking
Alkene pyrrolidone 80g, xanthan gum 80g, arbutin 80g, Kojic Acid Dipalmitate 80g, aluminum glycinate 8g, ethylenediaminetetraacetic acid two
Sodium 9g, tartaric acid 9g, aluminum sulfate 4.5g, imidazoles hydroxyurea 4.5g, methyl hydroxybenzoate 4g, malic acid 4g and purified water 10000g, so
Afterwards mix homogeneously, then inserts in hydrogel de-airing mixer and stirs;Pressure is 0.07Mpa during stirring, and temperature is 45 DEG C,
After 65min, hydrogel 15800g is obtained, it is stand-by.
4th, the preparation of finished product:
The hydrogel 15800g and Chinese medicine ointment 2400g are weighed, first uniform mixing, then inserts hydrogel and cut into slices on foot
In machine, coating, section are placed 72 hours under room temperature, and solidification gets product Flos Rosae Rugosae quintessence oil hydrogel plaster, and then encapsulation is preserved.
Embodiment 7
1st, the preparation of Flos Rosae Rugosae quintessence oil:
Flos Rosae Rugosae is put in extractor, using carbon dioxide supercritical extraction is carried out, collected extract and obtain final product rhodamine toner
Oil, it is stand-by.
2nd, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 1000g, Flos persicae 1000g, Folium Kaki 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Ampelopsis 1000g, Herba Hedyotidis Diffusae
In 1000g, Radix Cynanchi Atrati 1000g, Poria 1000g, Folium Eriobotryae 1000g, Radix Scutellariae 200g, Radix Glycyrrhizae 200g, Radix Stephaniae Tetrandrae 200g and step 1
Flos Rosae Rugosae quintessence oil 240g, then insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 50000g;Heating described in boil irrigate by lifting water to a higher level with a water pump, etc. to
Solution boiling in filling, after boiling 5h is kept, filters at once;Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boiled toward described
Add water 50000g in irrigating by lifting water to a higher level with a water pump, etc.;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling, after boiling 4h is kept, filter at once;By gained
Filtering residue 2 is inserted in boiling and irrigating by lifting water to a higher level with a water pump, etc. again, then toward it is described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 50000g;Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. into filling solution boiling
Rise, after boiling 3.5h is kept, filter at once;Three gained filtrates are merged, is fitted in concentration tank and is concentrated, until its phase
It is 1.4 to proportion, obtains Chinese medicine ointment finished product 4800g;Room temperature is cooled to, 48g ethanol is added, sealing preserve is carried out, it is stand-by.
3rd, the preparation of hydrogel:
Weigh glycerol 6000g, sodium polyacrylate 1500g, ethylene glycol 500g, polyvinylpyrrolidone 500g, the poly- second of crosslinking
Alkene pyrrolidone 100g, xanthan gum 100g, arbutin 100g, Kojic Acid Dipalmitate 100g, aluminum glycinate 10g, ethylenediamine tetraacetic
Acetic acid disodium 10g, tartaric acid 10g, aluminum sulfate 5g, imidazoles hydroxyurea 5g, methyl hydroxybenzoate 5g, malic acid 5g and purified water
12000g, then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs;Pressure is 0.08Mpa during stirring, and temperature is
50 DEG C, after 70min, hydrogel 18800g is obtained, it is stand-by.
4th, the preparation of finished product:
The hydrogel 18800g and Chinese medicine ointment 3300g are weighed, first uniform mixing, then inserts hydrogel and cut into slices on foot
In machine, coating, section are placed 72 hours under room temperature, and solidification gets product Flos Rosae Rugosae quintessence oil hydrogel plaster, and then encapsulation is preserved.
Randomly choose a piece of Pu-erh tea essential oil hydrogel plaster respectively from embodiment 1~7, be labeled as sticker 1,2,3,4,5,
6、7。
Microbiologic inhibition tests are carried out to sticker 1,2,3,4,5,6,7, table 1 is referred to.
Table 1
Hygienic chemistry detection is carried out to sticker 1,2,3,4,5,6,7, table 2 is referred to.
Table 2
Acute skin irritation test is carried out to sticker 1,2,3,4,5,6,7.
Regular grade new zealand white rabbit without exception 14 is chosen, 7 groups are randomly divided into, group 1,2,3,4,5,6,7 is labeled as, often
Group 2.Sticker 1,2,3,4,5,6,7 is tested respectively with group 1,2,3,4,5,6,7.
During test, temperature is:20~25 DEG C;Relative humidity:40%~70%.
According to Ministry of Public Health《Cosmetics health specification》(2007) acute skin irritation test.24h before test, test is dynamic
Thing back spinal column diamond wool cuts, not injured skin, each 3cm × 3cm of unhairing scope.Take tested material 0.5g and be directly applied to area
On the side unhairing intact skin of 2cm × 2cm, with the covering of clean gauze, to use nonirritant immobilization with adhesive tape.Opposite side skin is made
For control.Dismantle after 4h, with warm water residual tested material is removed.Remove tested material after 1,24,48,72h observation spreader portion
Position dermoreaction, with the meansigma methodss that animal subject is integrated overall merit is carried out, and according to 24,48 and 72h time point highest product is respectively observed
Divide average to judge the stimulated intensity of skin, obtain table 3.
Table 3
By table 1, table 2 and table 3 as can be seen that the Flos Rosae Rugosae quintessence oil hydrogel produced using technology provided by the present invention
Patch, its Matter Composition content complies fully with the People's Republic of China (PRC)《Cosmetics health specification》(2007) it is, very safe;Meanwhile,
Its zest to skin does not almost have, and people can be with the product safe to use.
Clinical trial
280 ages are selected in the general female volunteers of the facial skin of 20~60 years old, and age bracket be 20~30 years old,
30~40 years old, 40~50 years old and respectively there are 70 in 50~60 years old.During percent test object, following crowd is excluded:(1) gestation or
Women breast-feeding their children.(2) this programme implementer is affected with other serious conditions.(3) other whitening products are currently in use.(4)
Not by scheme medication, can not adhere to or the imperfect person of data.
280 female volunteers are divided into into 7 test groups, test group 1,2,3,4,5,6,7 is respectively labeled as, and are existed per group
Age bracket is respectively have 10 in 20~30 years old, 30~40 years old, 40~50 years old and 50~60 years old.Further according to the age, by 280 female
Property is divided into 4 groups, is labeled as 20~30 years old group, 30~40 years old group, 40~50 years old group and 50~60 years old group.
Randomly choose enough Flos Rosae Rugosae quintessence oil hydrogel plasters respectively from embodiment 1~7, be labeled as sticker 1., 2., 3., 4.,
5., 6., 7., then every volunteer in female volunteers' evening is affixed on during sleep, respectively test group 1,2,3,4,5,6,7
On the face, once a day, each one (specification is 12cm*11cm), each 8h,.
Flos Rosae Rugosae quintessence oil hydrogel plaster is stopped using after one month, and whitening effect statistics is carried out to 280 female volunteers,
Refer to table 4.The effect standard of whitening is:
It is effective:Facial skin is delicate;
Effectively:Relatively using before Flos Rosae Rugosae quintessence oil hydrogel plaster, facial skin improves significantly;
It is invalid:Relatively using before Flos Rosae Rugosae quintessence oil hydrogel plaster, facial skin is not improved.
Table 4
As can be seen from Table 4, the product that the present invention is provided, applicable crowd widely, is not only proper the green years
The Miss of 20 years old, or the grandma of 60 years old, when using the Flos Rosae Rugosae quintessence oil hydrogel plaster, the whitening effect of skin is all very
It is good.
Claims (9)
1. Flos Rosae Rugosae quintessence oil whitening hydrogel plaster, is made up of carrier and Chinese medicine ointment, it is characterised in that:The Chinese medicine ointment is by following
Raw material and its parts by weight are made:The weight portion of Semen Cassiae 10~100, the weight portion of Flos persicae 10~100, the weight of Folium Kaki 10~100
Part, the weight portion of the Rhizoma Atractylodis Macrocephalae 10~100, the weight portion of Radix Ampelopsis 10~100, the weight portion of Herba Hedyotidis Diffusae 10~100, the weight of Radix Cynanchi Atrati 10~100
Amount part, the weight portion of Poria 10~100, the weight portion of Folium Eriobotryae 10~100, the weight portion of Radix Scutellariae 2~20, the weight portion of Radix Glycyrrhizae 2~20,
The weight portion of Radix Stephaniae Tetrandrae 2~20 and the weight portion of Flos Rosae Rugosae quintessence oil 4~24.
2. Flos Rosae Rugosae quintessence oil whitening hydrogel plaster according to claim 1, it is characterised in that:The Chinese medicine ointment is by following original
Material and its parts by weight are made:It is the weight portion of Semen Cassiae 40~60, the weight portion of Flos persicae 40~60, the weight portion of Folium Kaki 40~60, white
The weight portion of art 40~60, the weight portion of Radix Ampelopsis 50~70, the weight portion of Herba Hedyotidis Diffusae 50~70, the weight portion of Radix Cynanchi Atrati 50~70, BAIFU
The weight portion of Siberian cocklebur 50~70, the weight portion of Folium Eriobotryae 50~70, the weight portion of Radix Scutellariae 8~12, the weight portion of Radix Glycyrrhizae 8~12, Radix Stephaniae Tetrandrae 8~12
Weight portion and the weight portion of Flos Rosae Rugosae quintessence oil 10~14.
3. Flos Rosae Rugosae quintessence oil whitening hydrogel plaster according to claim 1 and 2, it is characterised in that:The carrier is hydrogel.
4. Flos Rosae Rugosae quintessence oil whitening hydrogel plaster according to claim 3, it is characterised in that:The hydrogel is by following raw material
And its parts by weight are made:The weight portion of glycerol 60~600, the weight portion of sodium polyacrylate 15~150, the weight portion of ethylene glycol 5~50,
The weight portion of polyvinylpyrrolidone 5~50, the weight portion of crospolyvinylpyrrolidone 1~10, the weight portion of xanthan gum 1~10, Bearss
The weight portion of fruit glycosides 1~10, the weight portion of Kojic Acid Dipalmitate 1~10, the weight portion of aluminum glycinate 0.1~1, ethylenediaminetetraacetic acid two
The weight portion of sodium 0.1~1, the weight portion of tartaric acid 0.1~1, the weight portion of aluminum sulfate 0.05~0.5, the weight of imidazoles hydroxyurea 0.05~0.5
Amount part, the weight portion of methyl hydroxybenzoate 0.05~0.5, the weight portion of malic acid 0.05~0.5 and the weight portion of purified water 120~1200.
5. Flos Rosae Rugosae quintessence oil whitening hydrogel plaster according to claim 3, it is characterised in that:The hydrogel is by following raw material
And its parts by weight are made:The weight portion of glycerol 250~350, the weight portion of sodium polyacrylate 50~70, the weight of ethylene glycol 20~40
Part, the weight portion of polyvinylpyrrolidone 20~40, the weight portion of crospolyvinylpyrrolidone 4~6, the weight portion of xanthan gum 4~6,
The weight portion of arbutin 4~6, the weight portion of Kojic Acid Dipalmitate 4~6, the weight portion of aluminum glycinate 0.4~0.6, ethylenediaminetetraacetic acid
The weight portion of disodium 0.5~0.7, the weight portion of tartaric acid 0.5~0.7, the weight portion of aluminum sulfate 0.2~0.4, imidazoles hydroxyurea 0.2~
0.4 weight portion, the weight portion of methyl hydroxybenzoate 0.1~0.3, the weight portion of malic acid 0.1~0.3 and the weight portion of purified water 500~700.
6. a kind of preparation method of Flos Rosae Rugosae quintessence oil whitening hydrogel plaster as claimed in claim 4, comprises the steps:
A, Flos Rosae Rugosae is let off fireworks to be put in extractor, and using carbon dioxide supercritical extraction is carried out, and is collected extract and is obtained final product rhodamine toner
Oil, it is stand-by;
B, by weight, weighs Chinese medicine ointment raw material Semen Cassiae, Flos persicae, Folium Kaki, the Rhizoma Atractylodis Macrocephalae, Radix Ampelopsis, Herba Hedyotidis Diffusae, white
Common vetch, Poria, Folium Eriobotryae, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and the Flos Rosae Rugosae quintessence oil;Then the Chinese medicine ointment raw material is added into decocting
Boil, filter, be condensed into cream, obtain Chinese medicine ointment, it is stand-by;
C, by weight, weighs hydrogel raw materials glycerine, sodium polyacrylate, ethylene glycol, polyvinylpyrrolidone, is crosslinked poly- second
Alkene pyrrolidone, xanthan gum, arbutin, Kojic Acid Dipalmitate, aluminum glycinate, disodiumedetate, tartaric acid, sulphuric acid
Aluminum, imidazoles hydroxyurea, methyl hydroxybenzoate, malic acid and purified water;Then hydrogel raw material mixing is mixed thoroughly, obtains hydrogel,
It is stand-by;
D, the Chinese medicine ointment is mixed with the hydrogel, coated, section, solidification obtain final product Flos Rosae Rugosae quintessence oil whitening hydrogel
Patch.
7. the preparation method of Flos Rosae Rugosae quintessence oil whitening hydrogel plaster according to claim 6, it is characterised in that:Step b
In, the relative proportion of Chinese medicine ointment is 1.1~1.5.
8. the preparation method of Flos Rosae Rugosae quintessence oil whitening hydrogel plaster according to claim 6, it is characterised in that:Step c
In, when mixing is mixed thoroughly, the equipment of employing is hydrogel de-airing mixer;During mixing, pressure is 0.05~0.09Mpa,
Temperature is 40~50 DEG C, and the time is 55~75min.
9. the preparation method of Flos Rosae Rugosae quintessence oil whitening hydrogel plaster according to claim 6, it is characterised in that:Step d
In, mass ratio when Chinese medicine ointment mixes with hydrogel is 2~4:17~23.
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