CN104147186B - Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof - Google Patents
Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof Download PDFInfo
- Publication number
- CN104147186B CN104147186B CN201410345462.7A CN201410345462A CN104147186B CN 104147186 B CN104147186 B CN 104147186B CN 201410345462 A CN201410345462 A CN 201410345462A CN 104147186 B CN104147186 B CN 104147186B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- hydrogel
- flos rosae
- quintessence oil
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses Flos rosae multiflorae quintessence oil hydrogel plaster, be made up of carrier and Chinese medicine ointment；Described Chinese medicine ointment is made up of Semen Cassiae, Flos persicae, Folium Kaki, the Rhizoma Atractylodis Macrocephalae, Radix Peucedani, Herba Hedyotidis Diffusae, Folium Eriobotryae, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and Flos rosae multiflorae quintessence oil；Described carrier is hydrogel；Described Chinese medicine ointment raw material through boiling, filter, be condensed into cream, obtain Chinese medicine ointment；Then described Chinese medicine ointment being mixed with described hydrogel, final prepared transdermal absorption factor is high, and side effect is little, medicinal component long action time, the Flos rosae multiflorae quintessence oil hydrogel plaster that freckle effect is the most fairly obvious.
Description
Technical field
The present invention relates to skin care applications, be specifically related to Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof.
Background technology
Loving beauty is part of human nature.Especially women, more focuses on self, if having grown speckle on the face, as
Treat not in time, not only have impact on attractive in appearance, the most also can hit the self-confidence of women, cause emotion
Low, mental illness etc..
The most common speckle of women has chloasma, and it presents filbert also known as butterfly spot, chloasma hepaticum, in the form of sheets,
Differ in size, pigmented spots that shape differs, color mostly is filbert, yellowish-brown, also has coffee-like or light black
Color.Being distributed in around a near its circumference, forehead, cheekbone buccal, nose side and lip, border is clear generally symmetrically
Chu, surface skin is smooth, superficial, does not has scurf.Main cause is lost with endocrine, estrogen
Adjust relevant.Next is exactly cyasma, and its speckle form is dark brown, is distributed in the bridge of the nose, cheeks, it is possible to
See frons, in butterfly shape, be also " butterfly spot.Then be exactly disagreeable freckle, it be faint yellow,
Yellowish-brown or brown speckle, rounded, oval or irregular shape, mainly concentrate face, especially eyes
To two jaw protruding parts.Be more common in women, childhood period occur as soon as, the most obvious to adolescence, one to midsummer,
Freckle likes best adds trouble to.Finally, it is simply that senile plaque, this speckle seldom occurs, it cry again sun speckle or
Pigmented spots, in nail cover shape, brown, are common in back of people's hand, neck and the face of more than 40 years old.
The method of speckle dispelling, by multiple, can be treated with armrest art, but operative treatment is to cure the symptoms, not the disease, and does not has
Set about from root.Therefore, medicine is typically now used to treat speckle.Drug therapy is divided into again for oral administration and outer
Applying, responding time for oral administration is long, and a lot of patients, because giving the reason of kind of various kinds, can not adhere to getting off；Outward
The responding time applied is short, thus has the products such as substantial amounts of spot-dispelling liquid, QUBAN SHUANG and freckle-removing mask currently on the market,
But the freckle effect of these products on market is less desirable, and, its medicinal active ingredient also could not reach
Well absorbed by user, waste resource,
Number of patent application is the patent of invention of No. CN 201310616580.2, discloses a kind of traditional Chinese medicine freckle-removing group
Compound, traditional Chinese medicine freckle-removing preparation and traditional Chinese medicine freckle-removing facial film, its main medicinal component is for being by the Radix Angelicae Dahuricae 8～12g, the Pseudobulbus Bletillae (Rhizoma Bletillae)
8～12g, Rhizoma Typhonii 8～12g, Radix Ampelopsis 8～12g, the Rhizoma Atractylodis Macrocephalae 8～12g, Flos Chrysanthemi 8～12g, Radix Angelicae Sinensis 8～12g,
Olibanum 8～12g, Myrrha 8～12g, the Chinese medicine composition of Caulis Spatholobi 8～12g composition.First, this invention is special
Profit employs the Radix Angelicae Dahuricae prohibitted the use of in " cosmetics health specification " (2007)；Secondly, this patent of invention does not has
There is the absorption problem in view of effective medicinal component, although also have certain freckle effect, but significantly waste
Medicinal component, freckle effect is also arrived perfect condition.
Summary of the invention
For above the deficiencies in the prior art, the invention provides freckle effect substantially, medicinal component effect time
Between long, transdermal absorption factor is high and side effect is little Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof.
The technical solution used in the present invention is Flos rosae multiflorae quintessence oil hydrogel plaster, is made up of carrier and Chinese medicine ointment,
Described Chinese medicine ointment is made up of following raw material and parts by weight thereof: Semen Cassiae 10～100 weight portion, Flos persicae
10～100 weight portions, Folium Kaki 10～100 weight portion, the Rhizoma Atractylodis Macrocephalae 10～100 weight portion, Radix Peucedani 10～100 weight
Part, Herba Hedyotidis Diffusae 10～100 weight portion, Folium Eriobotryae 10～100 weight portion, Radix Scutellariae 2～20 weight portion, sweet
Grass 2～20 weight portions, Radix Stephaniae Tetrandrae 2～20 weight portion and Flos rosae multiflorae quintessence oil 4～24 weight portion.
Preferably, described Chinese medicine ointment is made up of following raw material and parts by weight thereof: Semen Cassiae 30～70 weight
Part, Flos persicae 30～70 weight portion, Folium Kaki 40～50 weight portion, the Rhizoma Atractylodis Macrocephalae 40～60 weight portion, Radix Peucedani 40～60
Weight portion, Herba Hedyotidis Diffusae 40～60 weight portion, Folium Eriobotryae 50～60 weight portion, Radix Scutellariae 7～13 weight portion,
Radix Glycyrrhizae 9～13 weight portion, Radix Stephaniae Tetrandrae 8～12 weight portion and Flos rosae multiflorae quintessence oil 12～16 weight portion.
Preferably, in order to improve the transdermal absorption factor of this speckle dispelling traditional Chinese medicine plaster, described carrier is hydrogel.
Preferably, described hydrogel is made up of following raw material and parts by weight thereof: glycerol 60～600 weight portion,
Sodium polyacrylate 15～150 weight portion, ethylene glycol 5～50 weight portion, polyvinylpyrrolidone 5～50 weight portion,
Crospolyvinylpyrrolidone 1～10 weight portion, xanthan gum 1～10 weight portion, Trenaxmine 1～10 weight portion,
Kojic Acid Dipalmitate 1～10 weight portion, aluminum glycinate 0.1～1 weight portion, oxalic acid triethylammonium tetrakis disodium 0.1～1
Weight portion, tartaric acid 0.1～1 weight portion, aluminum sulfate 0.05～0.5 weight portion, imidazoles hydroxyurea 0.05～0.5
Weight portion, methyl hydroxybenzoate 0.05～0.5 weight portion, malic acid 0.05～0.5 weight portion and purified water 120～1200
Weight portion.
Preferably, described hydrogel is made up of following raw material and parts by weight thereof: glycerol 200～400 weight portion,
Sodium polyacrylate 50～90 weight portion, ethylene glycol 20～40 weight portion, PVPK30～40 weight
Part, crospolyvinylpyrrolidone 5～7 weight portion, xanthan gum 4～8 weight portion, Trenaxmine 4～8 weight portion,
Kojic Acid Dipalmitate 5～7 weight portion, aluminum glycinate 0.4～0.6 weight portion, oxalic acid triethylammonium tetrakis disodium 0.5～0.7
Weight portion, tartaric acid 0.5～0.7 weight portion, aluminum sulfate 0.2～0.4 weight portion, imidazoles hydroxyurea 0.2～0.4 weight
Amount part, methyl hydroxybenzoate 0.1～0.3 weight portion, malic acid 0.1～0.3 weight portion and purified water 500～700 weight
Part.
The preparation method of a kind of above-mentioned Flos rosae multiflorae quintessence oil hydrogel plaster, comprises the steps:
A, the Flos rosae multiflorae is pulverized and puts in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by；
B, by weight, weigh Chinese medicine ointment raw material Semen Cassiae, Flos persicae, Folium Kaki, the Rhizoma Atractylodis Macrocephalae, Radix Peucedani,
Herba Hedyotidis Diffusae, Folium Eriobotryae, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and described Flos rosae multiflorae quintessence oil；Then by described
Medicine ointment raw material boiling, filter, be condensed into cream, obtain Chinese medicine ointment, stand-by；
C, by weight, weighs hydrogel raw materials glycerine, sodium polyacrylate, ethylene glycol, polyvinyl pyrrole
Alkanone, crospolyvinylpyrrolidone, xanthan gum, Trenaxmine, Kojic Acid Dipalmitate, aluminum glycinate,
Oxalic acid triethylammonium tetrakis disodium, tartaric acid, aluminum sulfate, imidazoles hydroxyurea, methyl hydroxybenzoate, malic acid and purification
Water；Then the mixing of described hydrogel raw material is mixed thoroughly, obtain hydrogel, stand-by；
D, described Chinese medicine ointment is mixed with described hydrogel, coated, cut into slices, solidify, obtain the Flos rosae multiflorae
Quintessence oil hydrogel plaster.
Preferably, so that described Chinese medicine ointment can not separate after mixing with described hydrogel, described step
In rapid b, the relative proportion of Chinese medicine ointment is 1.2～1.4
Preferably, in order to get rid of the gas in hydrogel, in described step c, when mixing is mixed thoroughly, use
Equipment be hydrogel de-airing mixer；During mix and blend, pressure is 0.05～0.09Mpa, and temperature is
35～55 DEG C, the time is 50～70min.
Preferably, so that the medicinal active ingredient in this lowering blood-fat and reducing weight traditional Chinese medicine plaster can be well by people
Body is absorbed, and in described step d, mass ratio when Chinese medicine ointment mixes with hydrogel is 2～4:17～23.
Semen Cassiae, has heat clearing away suppressing the hyperactive liver, blood fat-reducing blood pressure-decreasing, loosening bowel to relieve constipation, effect of improving eyesight benefit eyeball.
Flos persicae, has the effects such as happy skin of invigorating blood circulation, drastic purgation diuresis, blood-activating analgetic；The beautification function of Flos persicae, main
Containing kaempferol, perfume (or spice), bean essence, trifolin and the nutrient substance such as vitamin A, B, C in being derived from spending.
These materials can expand blood vessel, promotion of blood circulation, moist skin, improves blood circulation, promote skin-nourishing and
Oxygen supply, makes the lipofuscin element of promotion human senility accelerate excretion, prevents melanin chronic deposition in skin,
It is thus possible to effectively prevent chloasma, freckle, black speck, reach effect of whitening and speckle dispelling.
Folium Kaki, containing appreciable protein, aminoacid and multivitamin outside, possibly together with higher than general
Logical several times of the Folium Camelliae sinensis even natural Vc of tens times, and the 17 of rutin, choline, flavonoid glycoside and needed by human
Kind of amino acid whose content is also high tens times than water fruits and vegetables, common beverages；Natural Vc promotes that human body is the oldest
Metabolism, has certain curative effect to vitamin C deficiency, cardiovascular diseases and cancer etc.；Rutin, choline have vessel softening, prevent
The only effect of arteriosclerosis；Flavonoid glycoside can reduce blood pressure, increase blood flow volume, has golden yellow staphylococcus
Significantly inhibitory action.
The Rhizoma Atractylodis Macrocephalae, have spleen reinforcing, stomach reinforcing, dampness and in, antiabortive effect；Deficient QI of the spleen and stomach can be controlled, do not think
Diet, asthenia few gas, deficiency-distension, have loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness,
Spontaneous perspiration, nausea are uneasy；Also have slow down aging, effect of enhancing immunity, expand blood vessel, for skin
Whitening.
Radix Peucedani, has effect of dispelling wind-heat, the therapeutic method to keep the adverse QI flowing downwards, expectorant, wind heat can be controlled, expectorant heat syndrome cough is breathed heavily, vomiting,
Chest and diaphragm is full vexed.
Herba Hedyotidis Diffusae, have heat-clearing and toxic substances removing, XIAOFENG SAN gas, detumescent pain relieving, promoting urination to remove dampness, cure mainly lung-heat,
The diseases such as intestinal heat, laryngalgia, skin ulcer are swollen.
Folium Eriobotryae, has effect of removing heat from the lung and dissipating phlegm cough-relieving, stopping nausea and vomiting by lowering the adverse flow of QI, cures mainly that chronic cough is more than, spits blood, sends out
The diseases such as hot aversion to cold, vomiting, diphtheria.
Radix Scutellariae, heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions；Cure mainly epidemic febrile disease, upper respiratory tract infection, lung
Heat cough, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle
Deng disease, baicalin has (1) antiinflammatory, antiallergic, antiallergic action, protection sclerotin；(2) antipyretic, removing toxic substances and
Antipathogen；(3) function of gallbladder promoting, protect the liver and blood fat reducing；(4) calmness, blood pressure lowering, spasmolytic, diuresis, anticoagulant；(5) antioxygen
Change, anti-cataract, anticancer.
Radix Glycyrrhizae, tool invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, the mitigation property of medicine, the merit of coordinating the actions of various ingredients in a prescription, sweet
Grass agent has antiinflammatory and the function of resistance state reflection；Radix Glycyrrhizae or enoxolone have desoxycortone class effect；Radix Glycyrrhizae
Flavone there is antiinflammatory, spasmolytic and antiacid effect.
Radix Stephaniae Tetrandrae, tetrandrine have antiallergic (tetrandrine is an Anaphylactic mediator antagonist,
Be again an Anaphylactic mediator blocker, anaphylaxis had reliably antagonism and therapeutical effect), resisting hypertension
Deng effect.
Flos rosae multiflorae quintessence oil, has different physiological roles, and wherein anti-inflammatory response is one of its important function, with
Time have promote active component Transdermal absorption.
The useful of the present invention is: use above production technology, with Semen Cassiae, Flos persicae, Folium Kaki, the Rhizoma Atractylodis Macrocephalae,
Radix Peucedani, Herba Hedyotidis Diffusae, Folium Eriobotryae, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and Flos rosae multiflorae quintessence oil are raw material production
Chinese medicine ointment, has obvious freckle effect, because utilize is the anti-inflammatory component of pure plant, so its secondary work
With the most minimum.Meanwhile, by described Chinese medicine ointment and the water-setting using above specific components and production technology to produce
After glue mixing, the speckle dispelling traditional Chinese medicine plaster prepared, there is efficient transdermal absorption factor so that medical active becomes
Part can enter human body in a large number so that freckle effect becomes apparent from；Meanwhile, the oral secondary work caused is not only reduced
With, moreover it is possible to make part medical active composition not inactivated by the first pass effect of liver, so that active ingredient
Reach higher bioavailability.
Detailed description of the invention
For making those skilled in the art understand technique effect and the production technology thereof of the present invention in detail, below with tool
The production instance of body is further described application and the technique effect of the present invention.
Embodiment 1
1, the preparation of Flos rosae multiflorae quintessence oil:
Put into after the Flos rosae multiflorae is pulverized in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 100g, Flos persicae 100g, Folium Kaki 100g, Rhizoma Atractylodis Macrocephalae 100g, Radix Peucedani 100g, spend in vain
Herba Hedyotidis Diffusae 100g, Folium Eriobotryae 100g, Radix Scutellariae 20g, Radix Glycyrrhizae 20g, Radix Stephaniae Tetrandrae 20g and described Flos Rosae Multiflorae HUAJING
Oil 40g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boils the 3900g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc.
Solution boiling to filling, after keeping boiling 3.5h, filtration at once；Again insert to boil by gained filtering residue 1 and carry
In filling, then boil the 3900g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, protecting
After holding boiling 3.5h, filter at once；Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in and irrigate by lifting water to a higher level with a water pump, etc.
In add water 3900g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h, mistake at once
Filter；Three gained filtrates are merged, loads in concentration tank and concentrate, until its relative proportion is 1.2,
Chinese medicine ointment finished product 520g；It is cooled to room temperature, adds 5.2g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 600g, sodium polyacrylate 150g, ethylene glycol 50g, polyvinylpyrrolidone 50g, friendship
Connection polyvinylpyrrolidone 10g, xanthan gum 10g, Trenaxmine 10g, Kojic Acid Dipalmitate 10g, sweet ammonia
Acid aluminum 1g, oxalic acid triethylammonium tetrakis disodium 1g, tartaric acid 1g, aluminum sulfate 0.5g, imidazoles hydroxyurea 0.5g, hydroxyl
Benzene methyl 0.5g, malic acid 0.5g and purified water 1200g, then mix homogeneously, then insert hydrogel true
Empty blender stirs；During stirring, pressure is 0.05Mpa, and temperature is 30 DEG C, after 50min, obtains hydrogel
1950g, stand-by.
4, the preparation of finished product:
Weigh described hydrogel 1950g and Chinese medicine ointment 300g, the most uniformly mixing, then insert hydrogel on foot
In step microtome, being coated with, cut into slices, ambient temperatare is put 66 hours, and solidification, get product Flos rosae multiflorae quintessence oil water
Gel rubber plaster, then encapsulates preservation.
Embodiment 2
1, the preparation of Flos rosae multiflorae quintessence oil:
Put into after the Flos rosae multiflorae is pulverized in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 200g, Flos persicae 200g, Folium Kaki 200g, Rhizoma Atractylodis Macrocephalae 200g, Radix Peucedani 200g, spend in vain
Herba Hedyotidis Diffusae 200g, Folium Eriobotryae 200g, Radix Scutellariae 30g, Radix Glycyrrhizae 30g, Radix Stephaniae Tetrandrae 30g and described Flos Rosae Multiflorae HUAJING
Oil 80g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boils the 7700g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc.
Solution boiling to filling, after keeping boiling 3.5h, filtration at once；Again insert to boil by gained filtering residue 1 and carry
In filling, then boil the 7700g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, protecting
After holding boiling 3.5h, filter at once；Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in and irrigate by lifting water to a higher level with a water pump, etc.
In add water 7700g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4h, filtration at once；
Three gained filtrates are merged, loads in concentration tank and concentrate, until its relative proportion is 1.3, obtain Chinese medicine
Ointment finished product 800g；It is cooled to room temperature, adds 8g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 1400g, sodium polyacrylate 350g, ethylene glycol 100g, polyvinylpyrrolidone 200g,
Crospolyvinylpyrrolidone 30g, xanthan gum 30g, Trenaxmine 30g, Kojic Acid Dipalmitate 30g, sweet
Propylhomoserin aluminum 3g, oxalic acid triethylammonium tetrakis disodium 3g, tartaric acid 3g, aluminum sulfate 1g, imidazoles hydroxyurea 1g, hydroxyl
Benzene methyl 0.5g, malic acid 0.5g and purified water 4000g, then mix homogeneously, then insert hydrogel true
Empty blender stirs；During stirring, pressure is 0.06Mpa, and temperature is 35 DEG C, after 50min, obtains hydrogel
5600g, stand-by.
4, the preparation of finished product:
Weigh described hydrogel 5600g and Chinese medicine ointment 800g, the most uniformly mixing, then insert hydrogel on foot
In step microtome, being coated with, cut into slices, ambient temperatare is put 68 hours, and solidification, get product Flos rosae multiflorae quintessence oil water
Gel rubber plaster, then encapsulates preservation.
Embodiment 3
1, the preparation of Flos rosae multiflorae quintessence oil:
Put into after the Flos rosae multiflorae is pulverized in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 300g, Flos persicae 300g, Folium Kaki 400g, Rhizoma Atractylodis Macrocephalae 400g, Radix Peucedani 400g, spend in vain
Herba Hedyotidis Diffusae 400g, Folium Eriobotryae 500g, Radix Scutellariae 70g, Radix Glycyrrhizae 90g, Radix Stephaniae Tetrandrae 80g and described Flos Rosae Multiflorae HUAJING
Oil 120g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boils the 15600g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and carry
Fill to filling solution boiling, after keeping boiling 4.5h, filtration at once；Gained filtering residue 1 is inserted again and boils
In irrigating by lifting water to a higher level with a water pump, etc., then boil the 15600g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling,
After keeping boiling 4h, filter at once；Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in and carry
Add water in filling 15600g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h, at once
Filter；Three gained filtrates are merged, loads in concentration tank and concentrate, until its relative proportion is 1.3,
Obtain Chinese medicine ointment finished product 1500g；It is cooled to room temperature, adds 15g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 2000g, sodium polyacrylate 500g, ethylene glycol 200g, PVPK30 0g,
Crospolyvinylpyrrolidone 50g, xanthan gum 40g, Trenaxmine 40g, Kojic Acid Dipalmitate 50g, sweet
Propylhomoserin aluminum 4g, oxalic acid triethylammonium tetrakis disodium 5g, tartaric acid 5g, aluminum sulfate 2g, imidazoles hydroxyurea 2g, hydroxyl
Benzene methyl 1g, malic acid 1g and purified water 5000g, then mix homogeneously, then insert hydrogel vacuum and stir
Mix in machine and stir；During stirring, pressure is 0.06Mpa, and temperature is 38 DEG C, after 58min, obtains hydrogel 7600g,
Stand-by.
4, the preparation of finished product:
Weigh described hydrogel 7600g and Chinese medicine ointment 1300g, the most uniformly mixing, then insert hydrogel on foot
In step microtome, being coated with, cut into slices, ambient temperatare is put 69 hours, and solidification, get product Flos rosae multiflorae quintessence oil water
Gel rubber plaster, then encapsulates preservation.
Embodiment 4
1, the preparation of Flos rosae multiflorae quintessence oil:
Put into after the Flos rosae multiflorae is pulverized in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 500g, Flos persicae 500g, Folium Kaki 450g, Rhizoma Atractylodis Macrocephalae 500g, Radix Peucedani 500g, spend in vain
Herba Hedyotidis Diffusae 500g, Folium Eriobotryae 550g, Radix Scutellariae 90g, Radix Glycyrrhizae 110g, Radix Stephaniae Tetrandrae 100g and the described Flos rosae multiflorae
Quintessence oil 140g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boils the 19700g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating
Irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 5h, filtration at once；Gained filtering residue 1 is inserted again and boils
In irrigating by lifting water to a higher level with a water pump, etc., then boil the 19700g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling,
After keeping boiling 4.5h, filter at once；Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in
Add water in irrigating by lifting water to a higher level with a water pump, etc. 19700g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h, horse
Upper filtration；Three gained filtrates are merged, loads in concentration tank and concentrate, until its relative proportion is 1.3,
Obtain Chinese medicine ointment finished product 2000g；It is cooled to room temperature, reenters 20g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 3000g, sodium polyacrylate 700g, ethylene glycol 300g, polyvinylpyrrolidone 350g,
Crospolyvinylpyrrolidone 60g, xanthan gum 60g, Trenaxmine 60g, Kojic Acid Dipalmitate 60g, sweet
Propylhomoserin aluminum 5g, oxalic acid triethylammonium tetrakis disodium 6g, tartaric acid 6g, aluminum sulfate 3g, imidazoles hydroxyurea 3g, hydroxyl
Benzene methyl 2g, malic acid 2g and purified water 6000g, then mix homogeneously, then insert hydrogel vacuum and stir
Mix in machine and stir；During stirring, pressure is 0.07Mpa, and temperature is 40 DEG C, after 55min, obtains hydrogel 9800g,
Stand-by.
4, the preparation of finished product:
Weigh described hydrogel 9800g and Chinese medicine ointment 1700g, the most uniformly mixing, then insert hydrogel on foot
In step microtome, being coated with, cut into slices, ambient temperatare is put 70 hours, and solidification, get product Flos rosae multiflorae quintessence oil water
Gel rubber plaster, then encapsulates preservation.
Embodiment 5
1, the preparation of Flos rosae multiflorae quintessence oil:
Put into after the Flos rosae multiflorae is pulverized in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 700g, Flos persicae 700g, Folium Kaki 500g, Rhizoma Atractylodis Macrocephalae 600g, Radix Peucedani 600g, spend in vain
Herba Hedyotidis Diffusae 600g, Folium Eriobotryae 600g, Radix Scutellariae 130g, Radix Glycyrrhizae 130g, Radix Stephaniae Tetrandrae 120g and the described Flos rosae multiflorae
Quintessence oil 160g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boils the 24600g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating
Irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4h, filtration at once；Gained filtering residue 1 is inserted again and boils
In irrigating by lifting water to a higher level with a water pump, etc., then boil the 24600g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling,
After keeping boiling 4h, filter at once；Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in and carry
Add water in filling 24600g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4h, mistake at once
Filter；Three gained filtrates are merged, loads in concentration tank and concentrate, until its relative proportion is 1.3,
Chinese medicine ointment finished product 2500g；It is cooled to room temperature, adds 25g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 4000g, sodium polyacrylate 900g, ethylene glycol 400g, PVP 0g,
Crospolyvinylpyrrolidone 70g, xanthan gum 80g, Trenaxmine 80g, Kojic Acid Dipalmitate 70g, sweet
Propylhomoserin aluminum 6g, oxalic acid triethylammonium tetrakis disodium 7g, tartaric acid 7g, aluminum sulfate 4g, imidazoles hydroxyurea 4g, hydroxyl
Benzene methyl 3g, malic acid 3g and purified water 7000g, then mix homogeneously, then insert hydrogel vacuum and stir
Mix in machine and stir；During stirring, pressure is 0.07Mpa, and temperature is 40 DEG C, after 60min, obtains hydrogel 12100g,
Stand-by.
4, the preparation of finished product:
Weighing described hydrogel 12100g and Chinese medicine ointment 2000g, the most uniformly mixing, then inserts hydrogel
On foot in microtome, being coated with, cut into slices, ambient temperatare is put 70 hours, and solidification, get product Flos rosae multiflorae quintessence oil
Hydrogel plaster, then encapsulates preservation.
Embodiment 6
1, the preparation of Flos rosae multiflorae quintessence oil:
Put into after the Flos rosae multiflorae is pulverized in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 800g, Flos persicae 800g, Folium Kaki 700g, Rhizoma Atractylodis Macrocephalae 800g, Radix Peucedani 800g, spend in vain
Herba Hedyotidis Diffusae 850g, Folium Eriobotryae 850g, Radix Scutellariae 160g, Radix Glycyrrhizae 160g, Radix Stephaniae Tetrandrae 160g and the described Flos rosae multiflorae
Quintessence oil 200g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boils the 16300g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating
Irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4.5h, filtration at once；Gained filtering residue 1 is inserted again
Boil in irrigating by lifting water to a higher level with a water pump, etc., then boil the 16300g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling,
After keeping boiling 4h, filter at once；Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in and carry
Add water in filling 16300g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h, at once
Filter；Three gained filtrates are merged, loads in concentration tank and concentrate, until its relative proportion is 1.25,
Obtain Chinese medicine ointment finished product 3300g；It is cooled to room temperature, adds 33g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 5000g, sodium polyacrylate 1300g, ethylene glycol 450g, polyvinylpyrrolidone 450g,
Crospolyvinylpyrrolidone 90g, xanthan gum 90g, Trenaxmine 90g, Kojic Acid Dipalmitate 90g, sweet
Propylhomoserin aluminum 8g, oxalic acid triethylammonium tetrakis disodium 9g, tartaric acid 9g, aluminum sulfate 4.5g, imidazoles hydroxyurea 4.5g,
Methyl hydroxybenzoate 4g, malic acid 4g and purified water 10000g, then mix homogeneously, then insert hydrogel true
Empty blender stirs；During stirring, pressure is 0.07Mpa, and temperature is 45 DEG C, after 65min, obtains hydrogel
16000g, stand-by.
4, the preparation of finished product:
Weighing described hydrogel 16000g and Chinese medicine ointment 2900g, the most uniformly mixing, then inserts hydrogel
On foot in microtome, being coated with, cut into slices, ambient temperatare is put 72 hours, and solidification, get product Flos rosae multiflorae quintessence oil
Hydrogel plaster, then encapsulates preservation.
Embodiment 7
1, the preparation of Flos rosae multiflorae quintessence oil:
Put into after the Flos rosae multiflorae is pulverized in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Semen Cassiae 1000g, Flos persicae 1000g, Folium Kaki 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Peucedani 1000g,
Herba Hedyotidis Diffusae 1000g, Folium Eriobotryae 1000g, Radix Scutellariae 200g, Radix Glycyrrhizae 200g, Radix Stephaniae Tetrandrae 200g and described
Flos rosae multiflorae quintessence oil 240g, then inserts in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boils the 43000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Heating
Described boiling irrigates by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 5h, and filtration at once；By gained filtering residue 1 again
Insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil the 43000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. solution to filling
Boiling, after keeping boiling 4h, filters at once；Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward institute
State boil irrigate by lifting water to a higher level with a water pump, etc. in add water 43000g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h,
Filter at once；Three gained filtrates are merged, loads in concentration tank and concentrate, until its relative proportion is
1.4, obtain Chinese medicine ointment finished product 3850g；It is cooled to room temperature, adds 38.5g ethanol, carry out sealing preservation,
Stand-by.
3, the preparation of hydrogel:
Weigh glycerol 6000g, sodium polyacrylate 1500g, ethylene glycol 500g, polyvinylpyrrolidone 500g,
Crospolyvinylpyrrolidone 100g, xanthan gum 100g, Trenaxmine 100g, Kojic Acid Dipalmitate 100g,
Aluminum glycinate 10g, oxalic acid triethylammonium tetrakis disodium 10g, tartaric acid 10g, aluminum sulfate 5g, imidazoles hydroxyurea 5g,
Methyl hydroxybenzoate 5g, malic acid 5g and purified water 12000g, then mix homogeneously, then insert hydrogel true
Empty blender stirs；During stirring, pressure is 0.08Mpa, and temperature is 50 DEG C, after 70min, obtains hydrogel
19200g, stand-by.
4, the preparation of finished product:
Weighing described hydrogel 19200g and Chinese medicine ointment 3400g, the most uniformly mixing, then inserts hydrogel
On foot in microtome, being coated with, cut into slices, ambient temperatare is put 72 hours, and solidification, get product Flos rosae multiflorae quintessence oil
Hydrogel plaster, then encapsulates preservation.
From embodiment 1～7, randomly choose a piece of Flos rosae multiflorae quintessence oil hydrogel plaster respectively, be labeled as sticker 1,2,
3、4、5、6、7。
Sticker 1,2,3,4,5,6,7 is carried out microbiologic inhibition tests, refers to table 1.
Table 1
Sticker 1,2,3,4,5,6,7 is carried out hygienic chemistry detection, refers to table 2.
Table 2
Sticker 1,2,3,4,5,6,7 is carried out acute skin irritation test.
Choose regular grade new zealand white rabbit without exception 14, be randomly divided into 7 groups, be labeled as organizing 1,2,3,
4,5,6,7, often group 2.Sticker 1,2,3,4,5,6,7 respectively with group 1,2,3,4,5,
6,7 test.
During test, temperature is: 20～25 DEG C；Relative humidity: 40%～70%.
Test according to Ministry of Public Health " cosmetics health specification " (2007) acute skin irritation.24h before test,
Experimental animal back spinal column diamond wool is cut, not injured skin, each 3cm × 3cm of unhairing scope.Take tested
Thing 0.5g directly spreads upon on the side unhairing intact skin that area is 2cm × 2cm, covers with clean gauze,
Use nonirritant immobilization with adhesive tape.Opposite side skin is as comparison.Dismantle after 4h, remove residual with warm water
Stay tested material.Remove after tested material 1,24,48,72h observes and smears position dermoreaction, with animal subject
The meansigma methods of integration carries out overall merit, respectively observes time point top average according to 24,48 and 72h and judges
Skin irriate intensity, obtains table 3.
Table 3
By table 1, table 2 and table 3 it can be seen that use the Flos Rosae Multiflorae HUAJING that technology provided by the present invention is produced
Profit gel rubber plaster, its Matter Composition content complies fully with People's Republic of China's " cosmetics health specification "
(2007), the safest；Meanwhile, its to the zest of skin almost without, people can relieved use should
Product.
Clinical trial
Select 280 ages facial skin 20～60 years old and have the female volunteers of speckle, and age bracket is
20～30 years old, 30～40 years old, 40～50 years old and 50～in 60 years old, be respectively arranged with 70.During percent test object, will be with
Lower crowd gets rid of: (1) gestation or women breast-feeding their children.(2) suffer from other serious condition and affect this programme implementer.
(3) other speckle dispelling products it are currently in use.(4) not by scheme medication, can not adhere to or the imperfect person of data.
280 female volunteers are divided into 7 test group, be respectively labeled as test group 1,2,3,4,5,
6,7, and often group age bracket be 20～30 years old, 30～40 years old, 40～50 years old and 50～60 years old in be respectively arranged with 10
Name.Further according to the age, these 280 women are divided into 4 groups, be labeled as 20～30 years old group, 30～40 years old group,
40～50 years old group and 50～60 years old group.
From embodiment 1～7, randomly choose enough Flos rosae multiflorae quintessence oil hydrogel plasters respectively, be labeled as sticker 1.,
2., 3., 4., 5., 6., 7., then female volunteers evening in bed, be affixed on respectively test group 1,
2, in 3,4,5,6,7 every volunteer on the face, once a day, the most a piece of (specification is 12cm*11cm),
8h every time,.
Stop using Flos rosae multiflorae quintessence oil hydrogel plaster after one month, and 280 female volunteers are carried out speckle dispelling
Statistical effect, refers to table 4.In inspection with experimenter's area of speckle on the face, the color of speckle the degree of depth for observing
Index.The effect standard of speckle dispelling is:
Effective: clinical symptom disappearance, face is almost without speckle；The position of the longest speckle is without speckle or the most invisible
Speckle；
Effective: before relatively using Flos rosae multiflorae quintessence oil hydrogel plaster, the area of the speckle in face substantially diminishes, and speckle
Color substantially shoal；
Invalid: before relatively using Flos rosae multiflorae quintessence oil hydrogel plaster, the area of the speckle in face is almost unchanged, and speckle
Color be not improved.
Table 4
As can be seen from Table 4, the product that the present invention provides, applicable crowd widely, is not only proper blue or green
The Miss of 20 years old of time in spring, or the grandma of 60 years old, when using this Flos rosae multiflorae quintessence oil hydrogel plaster,
The freckle effect of skin is the best.
Claims (9)
1. Flos rosae multiflorae quintessence oil hydrogel plaster, is made up of carrier and Chinese medicine ointment, it is characterised in that: described Chinese medicine
Ointment is made up of following crude drug and parts by weight thereof: Semen Cassiae 10～100 weight portion, Flos persicae 10～100
Weight portion, Folium Kaki 10～100 weight portion, the Rhizoma Atractylodis Macrocephalae 10～100 weight portion, Radix Peucedani 10～100 weight portion,
Herba Hedyotidis Diffusae 10～100 weight portion, Folium Eriobotryae 10～100 weight portion, Radix Scutellariae 2～20 weight portion, sweet
Grass 2～20 weight portions, Radix Stephaniae Tetrandrae 2～20 weight portion and Flos rosae multiflorae quintessence oil 4～24 weight portion.
Flos rosae multiflorae quintessence oil hydrogel plaster the most according to claim 1, it is characterised in that: described Chinese medicines
Cream is made up of following crude drug and parts by weight thereof: Semen Cassiae 30～70 weight portion, Flos persicae 30～70 weight
Part, Folium Kaki 40～50 weight portion, the Rhizoma Atractylodis Macrocephalae 40～60 weight portion, Radix Peucedani 40～60 weight portion, Agkistrodon
SHECAO 40～60 weight portion, Folium Eriobotryae 50～60 weight portion, Radix Scutellariae 7～13 weight portion, Radix Glycyrrhizae 9～13
Weight portion, Radix Stephaniae Tetrandrae 8～12 weight portion and Flos rosae multiflorae quintessence oil 12～16 weight portion.
Flos rosae multiflorae quintessence oil hydrogel plaster the most according to claim 1 and 2, it is characterised in that: described load
Body is hydrogel.
Flos rosae multiflorae quintessence oil hydrogel plaster the most according to claim 3, it is characterised in that: described hydrogel
It is made up of following raw material and parts by weight thereof: glycerol 60～600 weight portion, sodium polyacrylate 15～150 weight
Amount part, ethylene glycol 5～50 weight portion, polyvinylpyrrolidone 5～50 weight portion, crosslinked polyethylene pyrroles
Alkanone 1～10 weight portion, xanthan gum 1～10 weight portion, Trenaxmine 1～10 weight portion, kojic acid two Petiolus Trachycarpi
Acid esters 1～10 weight portion, aluminum glycinate 0.1～1 weight portion, oxalic acid triethylammonium tetrakis disodium 0.1～1 weight
Part, tartaric acid 0.1～1 weight portion, aluminum sulfate 0.05～0.5 weight portion, imidazoles hydroxyurea 0.05～0.5
Weight portion, methyl hydroxybenzoate 0.05～0.5 weight portion, malic acid 0.05～0.5 weight portion and purified water 120～
1200 weight portions.
Flos rosae multiflorae quintessence oil hydrogel plaster the most according to claim 3, it is characterised in that: described hydrogel
It is made up of following raw material and parts by weight thereof: glycerol 200～400 weight portion, sodium polyacrylate 50～90 weight
Amount part, ethylene glycol 20～40 weight portion, PVPK30～40 weight portions, crosslinked polyethylene pyrrole
Pyrrolidone 5～7 weight portion, xanthan gum 4～8 weight portion, Trenaxmine 4～8 weight portion, kojic acid two Petiolus Trachycarpi
Acid esters 5～7 weight portion, aluminum glycinate 0.4～0.6 weight portion, oxalic acid triethylammonium tetrakis disodium 0.5～0.7 weight
Amount part, tartaric acid 0.5～0.7 weight portion, aluminum sulfate 0.2～0.4 weight portion, imidazoles hydroxyurea 0.2～0.4
Weight portion, methyl hydroxybenzoate 0.1～0.3 weight portion, malic acid 0.1～0.3 weight portion and purified water 500～
700 weight portions.
6. a preparation method for Flos rosae multiflorae quintessence oil hydrogel plaster as claimed in claim 4, including walking as follows
Rapid: a, the Flos rosae multiflorae to be pulverized and puts in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Flos rosae multiflorae quintessence oil, stand-by；
B, by weight, weigh Chinese medicine ointment crude drug Semen Cassiae, Flos persicae, Folium Kaki, the Rhizoma Atractylodis Macrocephalae, Radix Peucedani,
Herba Hedyotidis Diffusae, Folium Eriobotryae, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and described Flos rosae multiflorae quintessence oil；Then by described
Medicine ointment raw material boiling, filter, be condensed into cream, obtain Chinese medicine ointment, stand-by；
C, by weight, weighs hydrogel raw materials glycerine, sodium polyacrylate, ethylene glycol, polyvinyl pyrrole
Alkanone, crospolyvinylpyrrolidone, xanthan gum, Trenaxmine, Kojic Acid Dipalmitate, aluminum glycinate,
Oxalic acid triethylammonium tetrakis disodium, tartaric acid, aluminum sulfate, imidazoles hydroxyurea, methyl hydroxybenzoate, malic acid and purification
Water；Then the mixing of described hydrogel raw material is mixed thoroughly, obtain hydrogel, stand-by；
D, described Chinese medicine ointment is mixed with described hydrogel, coated, cut into slices, solidify, obtain the Flos rosae multiflorae
Quintessence oil hydrogel plaster.
The preparation method of Flos rosae multiflorae quintessence oil hydrogel plaster the most according to claim 6, its feature exists
In: in described step b, the relative proportion of Chinese medicine ointment is 1.2～1.4.
The preparation method of Flos rosae multiflorae quintessence oil hydrogel plaster the most according to claim 6, it is characterised in that:
In described step c, when mixing is mixed thoroughly, the equipment of employing is hydrogel de-airing mixer；During mix and blend,
Pressure is 0.05～0.09MPa, and temperature is 35～55 DEG C, and the time is 50～70min.
The preparation method of Flos rosae multiflorae quintessence oil hydrogel plaster the most according to claim 6, it is characterised in that:
In described step d, mass ratio when Chinese medicine ointment mixes with hydrogel is 2～4:17～23.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410345462.7A CN104147186B (en) | 2014-07-19 | 2014-07-19 | Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410345462.7A CN104147186B (en) | 2014-07-19 | 2014-07-19 | Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104147186A CN104147186A (en) | 2014-11-19 |
| CN104147186B true CN104147186B (en) | 2016-08-24 |
Family
ID=51872950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410345462.7A Expired - Fee Related CN104147186B (en) | 2014-07-19 | 2014-07-19 | Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104147186B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104784088A (en) * | 2015-03-19 | 2015-07-22 | 卢家雄 | Pure natural spot-lightening essential oil ointment |
| CN107898666A (en) * | 2017-10-11 | 2018-04-13 | 拉芳家化股份有限公司 | A kind of restoring consciouness of high-content geraniol plants essential oil synergy, anticreep hair-care shampoo |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223363C (en) * | 2002-12-31 | 2005-10-19 | 赵云会 | Medicinal composition with beauty function and its preparing method |
| CN103520013A (en) * | 2012-07-04 | 2014-01-22 | 江苏天晟药业有限公司 | Skin-whitening and freckle-removing formula and preparation method for gel thereof |
| CN103393568B (en) * | 2013-07-28 | 2015-09-30 | 娇时化妆品（杭州）有限公司 | A kind of whitening and spot eliminating cream |
-
2014
- 2014-07-19 CN CN201410345462.7A patent/CN104147186B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN104147186A (en) | 2014-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103656238B (en) | A kind of Chinese medicine composition for the treatment of rheumatic osteopathia | |
| CN104173264B (en) | Rose essence oil hydrogel patch and preparation method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN107308097A (en) | A kind of cosmetic constituent | |
| CN104127813A (en) | Traditional Chinese medicinal composition for curing qi-blood deficiency type bedsore and preparation method thereof | |
| CN104274754A (en) | Traditional Chinese medicine composition for treating infantile enuresis and preparation method of traditional Chinese medicine composition | |
| CN104147186B (en) | Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof | |
| CN102133167B (en) | Freckle removing facial mask made of traditional Chinese medicine and preparation process thereof | |
| CN102178781B (en) | Chinese medicine composition for treating scrotum eczema and preparation method thereof | |
| CN104666896A (en) | Orally-taken medicine for treating alopecia seborrhoeica and preparation method for orally-taken medicine | |
| CN107625828A (en) | A kind of health protection tea for auxiliary treatment chronic pharyngitis, preparation method and application | |
| CN101670044A (en) | Medicine for curing gestational chloasma and preparation method thereof | |
| CN105412697A (en) | Herba eupatorii oral liquid for clearing heat and removing dampness, and protecting liver and gallbladder and preparation method of oral liquid | |
| CN104940725A (en) | Dendrobium officinale traditional Chinese medicinal composition for nourishing blood and beautifying and preparation thereof | |
| CN107714798A (en) | A Chinese medicinal composition for treating chloasma, and its preparation method | |
| CN104524479B (en) | A kind of Chinese medicine composition for treating premenstrual syndrome and preparation method thereof | |
| CN106138785A (en) | One treats neurasthenic Chinese medicine composition and preparation method thereof | |
| CN105233056A (en) | Rhubarb oral liquid capable of clearing away heat and removing dampness and beneficial to choleresis and detoxification and preparation method of rhubarb oral liquid | |
| CN110141656A (en) | A kind of Fuke Tiaojing blood-nourishing Chinese medicine composition and preparation method thereof | |
| CN104857121A (en) | Drug combination for curing hyperlipidemia and application thereof | |
| CN104353043A (en) | Traditional Chinese medicine composition for treating dawn diarrhea and preparation method thereof | |
| CN111643557B (en) | Pharmaceutical composition for preventing and treating sequela of deep venous thrombosis of lower limbs and preparation method and application thereof | |
| CN104147152B (en) | Punica granatum L. quintessence oil hydrogel plaster and preparation method thereof | |
| CN108144038A (en) | A kind of Chinese medicine composition of eliminating chloasma and its application | |
| CN100496522C (en) | Medicinal composition containing propolis, preparation method and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160824 Termination date: 20200719 |