CN103520013A - Skin-whitening and freckle-removing formula and preparation method for gel thereof - Google Patents
Skin-whitening and freckle-removing formula and preparation method for gel thereof Download PDFInfo
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- CN103520013A CN103520013A CN201210228704.5A CN201210228704A CN103520013A CN 103520013 A CN103520013 A CN 103520013A CN 201210228704 A CN201210228704 A CN 201210228704A CN 103520013 A CN103520013 A CN 103520013A
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Abstract
The invention relates to a skin-whitening and freckle-removing formula and a preparation method for gel with the formula, and belongs to the field of pharmaceutical chemicals. The formula comprises high-purity EGCG (epigallocatechin gallate) and dipotassium glycyrrhizinate. The formula is characterized in that the mass ratio of EGCG to dipotassium glycyrrhizinate is (2 to 1) to (1 to 3), preferably (1 to 1) to (1 to 2), and the gel prepared by a dipotassium glycyrrhizinate hydrate, namely a gel matrix can be used for whitening skin and removing freckles. The preparation method has the advantages of high pharmaceutical activity, remarkable freckle-removing and inflammation-diminishing effects, simple process, stable state and the like, and is suitable for industrial production.
Description
Technical field
The preparation method that the invention discloses a kind of formula and gel thereof of whitening and speckle dispelling, belongs to field of medicine and chemical technology category.
Background technology
Because living environment is polluted, operating pressure is excessive, and wrinkle more easily appears in modern's skin, and cortex is aging, and the colour of skin is dimmed, lackluster, and mottle and allergic inflammation appear in groups of people's face.The formation of mottle is that melanic deposition causes, and melanic generation is subject to the impact of plurality of enzymes in cell, wherein tryrosinase is main rate-limiting enzyme, and this enzyme is a kind of cupric aerobic enzyme, at tyrosine, be converted in the course of reaction of DOPA, must have oxygen-derived free radicals to participate in.Therefore the synthetic necessary free radical of restraint of tyrosinase activity or elimination, can block melanic generation, moistens gradually pale skin, dissolves mottle.
Conventional arbutin, the kojic acid strong inhibition tryrosinase of whitening and speckle dispelling in current skin care item.Arbutin, as the derivant of hydroquinone, also there will be partly and untoward reaction like hydroquinones if local working concentration is excessive; Life-time service kojic acid has cytotoxicity, and can increase the probability of gonad cell chromosomal aberration.And a kind of pure natural, highly active antioxidant---EGCG obtaining that extract from Folium Camelliae sinensis, epigallocatechin gallate (EGCG) is becoming the new lover of high-end skin care item whitening and speckle dispelling.EGCG is mainly antioxidation to the effect of skin, when removing free radical, and activity that can restraint of tyrosinase, melanic formation is carried out to double blocking, therefore EGCG has very strong antioxidant activity, and its antioxidant capacity is at least ascorbic more than 100 times, 25 times of vitamin E.EGCG, as natural plants monomer, has following characteristics: molecular weight is little, very easily by human body skin, is absorbed, and has good Transdermal absorption performance; Activity is very stable, and temperature is atomic to its active variable effect, and under acid and black out condition, activity remains unchanged for a long time; Safe and reliable, through the check of relevant professional institution, its Toxicological testing shows to belong to nontoxic, nonirritant material, meets daily chemical products quality standard; Consumption is little, and effect is strong.In addition EGCG also has antitumor, mutation and antibacterial and anti-inflammation functions.
Glycyrrhizic acid dipotassium is the water soluble salt of glycyrrhizic acid, has gentle antiinflammatory, antiallergic effect and moisture-keeping efficacy, is generally added in the care product after Exposure to Sunlight, is used for eliminating the trickle inflammation on skin after strong Exposure to Sunlight.Glycyrrhizic acid dipotassium aspect anti-inflammation and EGCG there is coordinative role, still do not find that EGCG and glycyrrhizic acid dipotassium combine the report of use.
When glycyrrhizic acid dipotassium is found in research as effect composition, a certain proportion of glycyrrhizic acid dipotassium and water can form stable gel.As everyone knows, water-soluable gel is easily coated with exhibition, without greasy, non-stimulated to skin and mucosa, and after using, skin surface absorbs good simultaneously, quick permeation, and user is easy to accept, and is that a kind of utmost point has application prospect exterior-applied formulation.In China, gel, still in developmental stage, in early days as hospital preparation, is applied at department of dermatologry, surgery etc. to some extent at present.The applied gel matrix material of gel of domestic listing also seldom, has had a strong impact on applying of this dosage form.If can eliminate for example thick film sense of carbomer, this family macromolecule gel-type vehicle of cellulose itself as stable gel-type vehicle again as an effect composition, will be a brand-new gel undoubtedly simultaneously.
The formula of a kind of whitening and speckle dispelling provided by the invention and the preparation method of gel thereof, have the advantages such as pharmaceutically active is high, speckle dispelling antiinflammatory effect is remarkable, preparation method is simple, in stable condition, is applicable to industrialization simultaneously and produces.In disclosed patent and document, have no the report of related manufacturing processes.
Summary of the invention
The object of this invention is to provide a kind of pure natural, the significant external used medicine formula of whitening effect; Another object of the present invention is to provide a kind of gel preparation method that glycyrrhizic acid dipotassium hydrate is gel-type vehicle of take.
Whitening and speckle dispelling formula provided by the invention, consists of according to the following formulation EGCG, glycyrrhizic acid dipotassium, antiseptic, wetting agent:
In described formula, EGCG is that content is not less than 90% white powder; Glycyrrhizic acid dipotassium is that content must not be lower than 80% white powder; The mass ratio of EGCG and glycyrrhizic acid dipotassium is 1: 0.4～1: 3, and preferred proportion is 1: 1～1: 2.
In described formula, wetting agent comprises one or more in glycerol, propylene glycol, sorbitol.
In described formula, antiseptic comprises one or more in benzoate or quaternary ammonium salt.
In described formula, the aqueous solution of glycyrrhizic acid dipotassium can form hydrated gel in 0.2～5% scope, is preferably 0.8～3.0%, and in this concentration range, gel-type vehicle is water white transparency in 4 ℃～45 ℃ of temperature, and homogeneous, modest viscosity, is easy to smear.
The present invention also provides the preparation method of above-mentioned formula gel, and concrete preparation method is as described below:
(1) get EGCG and add appropriate purified water, stir at a certain temperature, obtain solution A;
(2) extracting liquorice acid dipotassium adds appropriate purified water, and stirring and dissolving is as gel-type vehicle at a certain temperature;
(3) in gel-type vehicle, add appropriate antiseptic, wetting agent stirring and evenly mixing at a certain temperature, obtain solution B;
(4) in solution A, add solution B at a certain temperature, and supply surplus water, mix homogeneously under stirring condition;
(5) by above-mentioned mixed solution, be cooled to 5 ℃, obtain water white gel, by the fill of gel divided dose, sealing.
Amount of water described in above-mentioned steps (1) is 5～15 times of EGCG weight, is preferably 8～10 times.Add water too sticky very little, add water excess, heat time heating time is long, the easy partial oxidation of EGCG; Solution temperature is 15 ℃～45 ℃, and preferably 20 ℃～30 ℃, optimum temperature is 25 ℃, and temperature is too low, dissolves not exclusively, and excess Temperature appearance causes EGCG oxidation.
Amount of water described in above-mentioned steps (2) is 5～15 times of glycyrrhizic acid dipotassium weight, is preferably 8～12 times; Solution temperature is 35 ℃～65 ℃, and preferably 55 ℃～60 ℃, temperature is too low, after dissolving, does not form and thaws, and excess Temperature industry is amplified easily affects product quality.
The temperature of above-mentioned steps (3) and step (4) is 35 ℃～65 ℃, and preferred 55 ℃～60 ℃, temperature is too low, cannot form solution and mix, and excess Temperature, EGCG is easily oxidized.
The inventor, through a large amount of screening and test, uses the certain density aqueous solution of glycyrrhizic acid dipotassium to form the characteristic of gel-type vehicle, is prepared into gel with EGCG combination, and both bring into play the synergy of whitening and speckle dispelling.The present invention is applied to the fields such as cosmetics, medical exterior-applied article and has following beneficial effect:
(1) this composition of medicine activity is high, and speckle dispelling antiinflammatory effect is remarkable;
(2) preparation method is simple, and the gel physics of compositions is in stable condition;
(3) water white transparency, active component purity is high;
(4) formula is gentle, does not make other gels, reduces the stimulation of skin and thick film sense;
(5) absorb rapidly, good penetrability, forms and has fine air permeability and certain water holding capacity at skin surface.
The specific embodiment
Following implementation content is for the technical characterictic to claim is described, and further illustrates practicality of the present invention, should not be construed as raw material sources of the present invention or limiting to the claimed invention.
Embodiment 1
Preparation method:
1, get EGCG15 gram, add 150 grams of water, at 25 ℃, stir, obtain solution A.
2,25 grams of extracting liquorice acid dipotassiums add 300 grams of water, are heated to 60 ℃, and stirring and evenly mixing forms transparent gel-type vehicle.
3, get 20 grams of propylene glycol, 0.5 gram of sodium benzoate, under constantly stirring, join in 60 ℃ of above-mentioned gel-type vehicles, obtain solution B.
4, solution B is heated to 60 ℃, joins in 55 ℃ of solution A, and mend 500 grams of water yields, mix homogeneously under stirring condition.
5, above-mentioned mixed solution is stirred to 30min, after mixing, be cooled to 5 ℃ and obtain water white gel products.Total amount 1000g, is packed as 50 altogether, every 20g, and EGCG content is 1.5%, glycyrrhizic acid dipotassium content is 2.5%.
Embodiment 2
Preparation method:
1, get EGCG20 gram, add 200 grams of water, at 25 ℃, stir, obtain solution A.
2,20 grams of extracting liquorice acid dipotassiums add 240 grams of water, are heated to 60 ℃, and stirring and evenly mixing forms transparent gel-type vehicle.
3, get 20 grams of glycerol, 0.5 gram of sodium benzoate, under constantly stirring, join in 60 ℃ of above-mentioned gel-type vehicles, obtain solution B.
4, solution B is heated to 60 ℃, joins in 55 ℃ of solution A, and mend 500 grams of water yields, mix homogeneously under stirring condition.
5, above-mentioned mixed solution is stirred to 30min, after mixing, be cooled to 5 ℃ and obtain water white gel products.Total amount 1000g, is packed as 50 altogether, every 20g, and EGCG content is 2.0%, glycyrrhizic acid dipotassium content is 2.0%.
Embodiment 3
1, get EGCG15 gram, add 150 grams of water, at 25 ℃, stir, obtain solution A.
2,20 grams of extracting liquorice acid dipotassiums add 250 grams of water, are heated to 60 ℃, and stirring and evenly mixing forms transparent gel-type vehicle.
3, get 20 grams of glycerol, polyquaternary ammonium salt-150.5 gram, under constantly stirring, join in 60 ℃ of above-mentioned gel-type vehicles, obtain solution B.
4, solution B is heated to 60 ℃, joins in 55 ℃ of solution A, and mend 550 grams of water yields, mix homogeneously under stirring condition.
5, above-mentioned mixed solution is stirred to 30min, after mixing, be cooled to 5 ℃ and obtain water white gel products.Total amount 1000g, is packed as 50 altogether, every 20g, and EGCG content is 1.5%, glycyrrhizic acid dipotassium content is 2.0%.
Claims (7)
1. a gel formula for whitening and speckle dispelling, is characterized in that forming in following ratio:
2. formula according to claim 1, is characterized in that in formula, EGCG is that content is not less than 90% white powder; Glycyrrhizic acid dipotassium is that content must not be lower than 80% white powder; The mass ratio of EGCG and glycyrrhizic acid dipotassium is 1: 0.4～1: 3, and preferred proportion is 1: 1～1: 2.
3. formula according to claim 1, is characterized in that wetting agent comprises one or more in glycerol, propylene glycol, sorbitol; Antiseptic comprises one or more in benzoate or quaternary ammonium salt.
4. according to any formula described in claim 1～3, it is characterized in that the preparation of its gel comprises the following steps:
(1) get EGCG and add suitable quantity of water, stir at a certain temperature, obtain solution A;
(2) extracting liquorice acid dipotassium adds suitable quantity of water, and stirring and dissolving is as gel-type vehicle at a certain temperature;
(3) to gel base, add appropriate antiseptic, wetting agent stirring and evenly mixing at a certain temperature, obtain solution B;
(4) in solution A, add solution B at a certain temperature, supply the water of prescription surplus, mix homogeneously under stirring condition;
(5) by above-mentioned mixed solution, be cooled to 5 ℃, obtain water white gel, by the fill of gel divided dose, sealing.
5. the preparation method of gel according to claim 4, is characterized in that the amount of water described in step (1) is 5～15 times of EGCG weight, is preferably 8～10 times; Solution temperature is 15 ℃～45 ℃, and preferably 20 ℃～30 ℃, optimum temperature is 25 ℃.
6. the preparation method of gel according to claim 4, is characterized in that the water yield described in step (2) is 5～15 times of glycyrrhizic acid dipotassium weight, is preferably 8～12 times; Solution temperature is 35 ℃～65 ℃, preferably 55 ℃～60 ℃.
7. the preparation method of gel according to claim 4, is characterized in that the temperature described in step (3) and (4) is 35 ℃～65 ℃, preferably 55 ℃～60 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210228704.5A CN103520013A (en) | 2012-07-04 | 2012-07-04 | Skin-whitening and freckle-removing formula and preparation method for gel thereof |
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| CN201210228704.5A CN103520013A (en) | 2012-07-04 | 2012-07-04 | Skin-whitening and freckle-removing formula and preparation method for gel thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042527A (en) * | 2014-07-08 | 2014-09-17 | 广州丹奇日用化工厂有限公司 | Freckle removing cosmetic composition and preparation method thereof |
| CN104095236A (en) * | 2014-07-21 | 2014-10-15 | 江苏天晟药业有限公司 | Health-care oral liquid capable of whitening and delaying aging and preparation method thereof |
| CN104147186A (en) * | 2014-07-19 | 2014-11-19 | 云南荣之健生物科技有限公司 | Rose essential oil hydrogel plaster and preparation method thereof |
| CN105055186A (en) * | 2015-07-17 | 2015-11-18 | 江苏天晟药业有限公司 | Skin care product having anti-allergy, moisturizing and sun-screening functions and preparation method of skin care product |
| CN107174577A (en) * | 2017-05-31 | 2017-09-19 | 盛林 | A kind of gel containing EGCG and preparation method thereof |
| CN107468539A (en) * | 2017-08-14 | 2017-12-15 | 北京明弘科贸有限责任公司 | One kind contains ascorbic sub- gel and preparation method and application |
| CN108434255A (en) * | 2018-01-11 | 2018-08-24 | 武汉华卫科技有限公司 | A kind of tea polyphenol composition |
| CN109381365A (en) * | 2018-12-29 | 2019-02-26 | 上海家化联合股份有限公司 | Thickener blend composition containing dipotassium glycyrrhizinate |
| CN112057359A (en) * | 2020-10-22 | 2020-12-11 | 北京唯爱生物科技有限公司 | Deep-sea pinus hirsuta moisturizing composition and preparation method and application thereof |
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| CN101522265A (en) * | 2006-07-31 | 2009-09-02 | 捷通国际有限公司 | Topical skin compositions, their preparation and their use |
| WO2012009298A2 (en) * | 2010-07-16 | 2012-01-19 | The Gillette Company | Personal care compositions comprising a multi-active system for down regulating cytokines irritation |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042527A (en) * | 2014-07-08 | 2014-09-17 | 广州丹奇日用化工厂有限公司 | Freckle removing cosmetic composition and preparation method thereof |
| CN104042527B (en) * | 2014-07-08 | 2016-08-10 | 广州丹奇日用化工厂有限公司 | Cosmetics compositions and preparation method thereof |
| CN104147186A (en) * | 2014-07-19 | 2014-11-19 | 云南荣之健生物科技有限公司 | Rose essential oil hydrogel plaster and preparation method thereof |
| CN104095236A (en) * | 2014-07-21 | 2014-10-15 | 江苏天晟药业有限公司 | Health-care oral liquid capable of whitening and delaying aging and preparation method thereof |
| CN105055186A (en) * | 2015-07-17 | 2015-11-18 | 江苏天晟药业有限公司 | Skin care product having anti-allergy, moisturizing and sun-screening functions and preparation method of skin care product |
| CN107174577A (en) * | 2017-05-31 | 2017-09-19 | 盛林 | A kind of gel containing EGCG and preparation method thereof |
| CN107468539A (en) * | 2017-08-14 | 2017-12-15 | 北京明弘科贸有限责任公司 | One kind contains ascorbic sub- gel and preparation method and application |
| CN108434255A (en) * | 2018-01-11 | 2018-08-24 | 武汉华卫科技有限公司 | A kind of tea polyphenol composition |
| CN109381365A (en) * | 2018-12-29 | 2019-02-26 | 上海家化联合股份有限公司 | Thickener blend composition containing dipotassium glycyrrhizinate |
| CN112057359A (en) * | 2020-10-22 | 2020-12-11 | 北京唯爱生物科技有限公司 | Deep-sea pinus hirsuta moisturizing composition and preparation method and application thereof |
| CN112057359B (en) * | 2020-10-22 | 2021-07-27 | 北京唯爱生物科技有限公司 | Deep-sea pinus hirsuta moisturizing composition and preparation method and application thereof |
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Application publication date: 20140122 |