CN108144038A - A kind of Chinese medicine composition of eliminating chloasma and its application - Google Patents
A kind of Chinese medicine composition of eliminating chloasma and its application Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/539—Scutellaria (skullcap)
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- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The present invention relates to a kind of Chinese medicine compositions of eliminating chloasma, are made of following bulk pharmaceutical chemicals：Radix bupleuri, Radix Codonopsis, Rhizoma Chuanxiong, sweet stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, jujube, radix scutellariae, Radix Glycyrrhizae, sweet bran stir-baked RADIX PAEONIAE ALBA, rhizoma alismatis, the tuber of pinellia processed, Radix Angelicae Sinensis, PORIA ALBA, rhizoma zingiberis.Its advantage is shown：The Chinese medicine composition compatibility of the present invention is proper, and each taste raw medicinal material comprehensive function can effective eliminating chloasma.The Chinese medicine composition of the present invention can significantly improve SOD activity in the blood and skin histology of the chloasma Pathological pattern animal as caused by irradiating ultraviolet light, reduce the content of MDA, reduce internal extent of peroxidation, oxidation resistance and Scavenging ability enhancing.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically, being Chinese medicine composition and its application of a kind of eliminating chloasma.
Background technology
Chloasma is a kind of acquired pigmentation skin disease, shows as pigment symmetry hyperpigmented skin disease, shows as color
Plain symmetry is calm, and in butterfly aliform, the lighter is faint yellow or light brown, and point sheet intersperses among cheek both sides, more with outside under eye
See, severe one is in dark brown or light/dark balance, is mainly in young women, is clinically common and is difficult to one of skin disease cured.
Chinese patent literature CN107714798A discloses a kind of Chinese medicine composition for being used to treat chloasma：Cassia twig, Fu
Siberian cocklebur, peach kernel, the radix paeoniae rubrathe, Radix Paeoniae Alba, the root bark of tree peony, Radix Angelicae Sinensis, radix bupleuri, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, peppermint, rose, safflower, armeniaca mume.Chinese patent text
It offers CN104587129A and discloses a kind of Chinese medicine for treating chloasma：Radix Paeoniae Alba, the root of Dahurain angelica, radix bupleuri, rhizoma atractylodis macrocephalae, stir-baked FRUCTUS GARDENIAE, dried orange peel, when
Return, safflower, radix scutellariae, moutan bark, peach kernel, rhizoma cyperi, honey-fried licorice root.Chinese patent literature CN102370726A, which is disclosed, a kind of treats Huang
The Chinese medicine of foxiness：Radix bupleuri, Poria cocos, Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, safflower, stiff silkworm, the root of Dahurain angelica.Chinese patent literature
CN102512644A discloses a kind of Chinese medicine of spot-removing beautifying face：Radix bupleuri, Rhizoma Atractylodis Macrocephalae, ginger, Radix Salviae Miltiorrhizae, peach kernel, sweet wormwood, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Radix Paeoniae Alba, stir-baked FRUCTUS GARDENIAE, rhizoma cyperi, moutan bark, peppermint, safflower.But about the present invention eliminating chloasma Chinese medicine composition and
Its application yet there are no report.
Invention content
First purpose of the present invention is, for deficiency of the prior art, to provide a kind of Chinese medicine group of eliminating chloasma
Close object.
Second object of the present invention is to provide a kind of application of Chinese medicine composition.
To realize above-mentioned first purpose, the technical solution adopted by the present invention is that：A kind of Chinese traditional medicine composition of eliminating chloasma
Object, the Chinese medicine composition are made of the bulk pharmaceutical chemicals of following parts by weight：10~20 parts of radix bupleuri, 7~13 parts of Radix Codonopsis, Rhizoma Chuanxiong 4~8
Part, sweet 10~20 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 20~40 parts of jujube, 6~12 parts of radix scutellariae, 2~4 parts of Radix Glycyrrhizae, sweet 10~20 parts of bran stir-baked RADIX PAEONIAE ALBA,
10~20 parts of rhizoma alismatis, 6~12 parts of the tuber of pinellia processed, 7~11 parts of Radix Angelicae Sinensis, 10~20 parts of PORIA ALBA, 4~8 parts of rhizoma zingiberis.
Preferably, the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight：13~17 parts of radix bupleuri, Radix Codonopsis 9~
11 parts, 5~7 parts of Rhizoma Chuanxiong, sweet 13~17 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 25~35 parts of jujube, 8~10 parts of radix scutellariae, 2.5~3.5 parts of Radix Glycyrrhizae, honey
13~17 parts of bran stir-baked RADIX PAEONIAE ALBA, 13~17 parts of rhizoma alismatis, 8~10 parts of the tuber of pinellia processed, 8~10 parts of Radix Angelicae Sinensis, 13~17 parts of PORIA ALBA, rhizoma zingiberis 5
~7 parts.
It is furthermore preferred that the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight：15 parts of radix bupleuri, 10 parts of Radix Codonopsis,
6 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 9 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, sweet 15 parts of bran stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, system half
9 parts of summer, 9 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
To realize above-mentioned second purpose, the technical solution adopted by the present invention is that：The Chinese medicine composition is dispelled in preparation
Except the application in the drug or health products of chloasma.
Preferably, the drug is oral drugs.
The invention has the advantages that：
1st, Chinese medicine composition compatibility of the invention is proper, and each taste raw medicinal material comprehensive function can effective eliminating chloasma.
2nd, Chinese medicine composition of the invention can significantly improve the chloasma Pathological pattern animal as caused by irradiating ultraviolet light
SOD activity in blood and skin histology reduces the content of MDA, reduces internal extent of peroxidation, and oxidation resistance and removing are certainly
Enhanced by base ability.
Specific embodiment
It elaborates with reference to embodiment to specific embodiment provided by the invention.
Embodiment 1
15 parts of radix bupleuri, 10 parts of Radix Codonopsis, 6 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 9 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, honey
15 parts of bran stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 9 parts of the tuber of pinellia processed, 9 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
Embodiment 2
13 parts of radix bupleuri, 9 parts of Radix Codonopsis, 5 parts of Rhizoma Chuanxiong, sweet 13 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 25 parts of jujube, 8 parts of radix scutellariae, 2.5 parts of Radix Glycyrrhizae, honey
13 parts of bran stir-baked RADIX PAEONIAE ALBA, 13 parts of rhizoma alismatis, 8 parts of the tuber of pinellia processed, 8 parts of Radix Angelicae Sinensis, 13 parts of PORIA ALBA, 5 parts of rhizoma zingiberis.
Embodiment 3
13 parts of radix bupleuri, 10 parts of Radix Codonopsis, 6 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 25 parts of jujube, 9 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, honey
15 parts of bran stir-baked RADIX PAEONIAE ALBA, 13 parts of rhizoma alismatis, 9 parts of the tuber of pinellia processed, 9 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 5 parts of rhizoma zingiberis.
Embodiment 4
13 parts of radix bupleuri, 11 parts of Radix Codonopsis, 7 parts of Rhizoma Chuanxiong, sweet 17 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 25 parts of jujube, 10 parts of radix scutellariae, 3.5 parts of Radix Glycyrrhizae,
Sweet 17 parts of bran stir-baked RADIX PAEONIAE ALBA, 13 parts of rhizoma alismatis, 10 parts of the tuber of pinellia processed, 10 parts of Radix Angelicae Sinensis, 17 parts of PORIA ALBA, 5 parts of rhizoma zingiberis.
Embodiment 5
15 parts of radix bupleuri, 9 parts of Radix Codonopsis, 6 parts of Rhizoma Chuanxiong, sweet 17 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 8 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, sweet bran
17 parts of stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 8 parts of the tuber of pinellia processed, 9 parts of Radix Angelicae Sinensis, 17 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
Embodiment 6
15 parts of radix bupleuri, 10 parts of Radix Codonopsis, 7 parts of Rhizoma Chuanxiong, sweet 13 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 9 parts of radix scutellariae, 3.5 parts of Radix Glycyrrhizae,
Sweet 13 parts of bran stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 9 parts of the tuber of pinellia processed, 10 parts of Radix Angelicae Sinensis, 13 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
Embodiment 7
15 parts of radix bupleuri, 11 parts of Radix Codonopsis, 5 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 10 parts of radix scutellariae, 2.5 parts of Radix Glycyrrhizae,
Sweet 15 parts of bran stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 10 parts of the tuber of pinellia processed, 8 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
Embodiment 8
17 parts of radix bupleuri, 9 parts of Radix Codonopsis, 7 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 35 parts of jujube, 8 parts of radix scutellariae, 3.5 parts of Radix Glycyrrhizae, honey
15 parts of bran stir-baked RADIX PAEONIAE ALBA, 17 parts of rhizoma alismatis, 8 parts of the tuber of pinellia processed, 10 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 7 parts of rhizoma zingiberis.
Embodiment 9
17 parts of radix bupleuri, 10 parts of Radix Codonopsis, 5 parts of Rhizoma Chuanxiong, sweet 17 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 35 parts of jujube, 9 parts of radix scutellariae, 2.5 parts of Radix Glycyrrhizae,
Sweet 17 parts of bran stir-baked RADIX PAEONIAE ALBA, 17 parts of rhizoma alismatis, 9 parts of the tuber of pinellia processed, 8 parts of Radix Angelicae Sinensis, 17 parts of PORIA ALBA, 7 parts of rhizoma zingiberis.
Embodiment 10
17 parts of radix bupleuri, 11 parts of Radix Codonopsis, 6 parts of Rhizoma Chuanxiong, sweet 13 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 35 parts of jujube, 10 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, honey
13 parts of bran stir-baked RADIX PAEONIAE ALBA, 17 parts of rhizoma alismatis, 10 parts of the tuber of pinellia processed, 9 parts of Radix Angelicae Sinensis, 13 parts of PORIA ALBA, 7 parts of rhizoma zingiberis.
Embodiment 11
10 parts of radix bupleuri, 7 parts of Radix Codonopsis, 4 parts of Rhizoma Chuanxiong, sweet 10 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 20 parts of jujube, 6 parts of radix scutellariae, 2 parts of Radix Glycyrrhizae, sweet bran
10 parts of stir-baked RADIX PAEONIAE ALBA, 10 parts of rhizoma alismatis, 6 parts of the tuber of pinellia processed, 6 parts of Radix Angelicae Sinensis, 10 parts of PORIA ALBA, 4 parts of rhizoma zingiberis.
Embodiment 12
10 parts of radix bupleuri, 10 parts of Radix Codonopsis, 6 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 20 parts of jujube, 9 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, honey
15 parts of bran stir-baked RADIX PAEONIAE ALBA, 10 parts of rhizoma alismatis, 9 parts of the tuber of pinellia processed, 9 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 4 parts of rhizoma zingiberis.
Embodiment 13
10 parts of radix bupleuri, 13 parts of Radix Codonopsis, 8 parts of Rhizoma Chuanxiong, sweet 20 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 20 parts of jujube, 12 parts of radix scutellariae, 4 parts of Radix Glycyrrhizae, honey
20 parts of bran stir-baked RADIX PAEONIAE ALBA, 10 parts of rhizoma alismatis, 12 parts of the tuber of pinellia processed, 12 parts of Radix Angelicae Sinensis, 20 parts of PORIA ALBA, 4 parts of rhizoma zingiberis.
Embodiment 14
15 parts of radix bupleuri, 7 parts of Radix Codonopsis, 6 parts of Rhizoma Chuanxiong, sweet 20 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 6 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, sweet bran
20 parts of stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 6 parts of the tuber of pinellia processed, 9 parts of Radix Angelicae Sinensis, 20 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
Embodiment 15
15 parts of radix bupleuri, 10 parts of Radix Codonopsis, 8 parts of Rhizoma Chuanxiong, sweet 10 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 9 parts of radix scutellariae, 4 parts of Radix Glycyrrhizae, honey
10 parts of bran stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 9 parts of the tuber of pinellia processed, 12 parts of Radix Angelicae Sinensis, 10 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
Embodiment 16
15 parts of radix bupleuri, 13 parts of Radix Codonopsis, 4 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 12 parts of radix scutellariae, 2 parts of Radix Glycyrrhizae, honey
15 parts of bran stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 12 parts of the tuber of pinellia processed, 6 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
Embodiment 17
20 parts of radix bupleuri, 7 parts of Radix Codonopsis, 8 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 40 parts of jujube, 6 parts of radix scutellariae, 4 parts of Radix Glycyrrhizae, sweet bran
15 parts of stir-baked RADIX PAEONIAE ALBA, 20 parts of rhizoma alismatis, 6 parts of the tuber of pinellia processed, 12 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 8 parts of rhizoma zingiberis.
Embodiment 18
20 parts of radix bupleuri, 10 parts of Radix Codonopsis, 4 parts of Rhizoma Chuanxiong, sweet 20 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 40 parts of jujube, 9 parts of radix scutellariae, 2 parts of Radix Glycyrrhizae, honey
20 parts of bran stir-baked RADIX PAEONIAE ALBA, 20 parts of rhizoma alismatis, 9 parts of the tuber of pinellia processed, 6 parts of Radix Angelicae Sinensis, 20 parts of PORIA ALBA, 8 parts of rhizoma zingiberis.
Embodiment 19
20 parts of radix bupleuri, 13 parts of Radix Codonopsis, 6 parts of Rhizoma Chuanxiong, sweet 10 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 40 parts of jujube, 12 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, honey
10 parts of bran stir-baked RADIX PAEONIAE ALBA, 20 parts of rhizoma alismatis, 12 parts of the tuber of pinellia processed, 9 parts of Radix Angelicae Sinensis, 10 parts of PORIA ALBA, 8 parts of rhizoma zingiberis.
Comparative example 1
6 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, sweet 15 parts of bran stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 9 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA.
Comparative example 2
15 parts of radix bupleuri, 10 parts of Radix Codonopsis, 30 parts of jujube, 9 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae, 9 parts of the tuber of pinellia processed, 6 parts of rhizoma zingiberis.
Comparative example 3
10 parts of radix bupleuri, 10 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiong, sweet 10 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 10 parts of jujube, 10 parts of radix scutellariae, 10 parts of Radix Glycyrrhizae,
Sweet 10 parts of bran stir-baked RADIX PAEONIAE ALBA, 10 parts of rhizoma alismatis, 10 parts of the tuber of pinellia processed, 10 parts of Radix Angelicae Sinensis, 10 parts of PORIA ALBA, 10 parts of rhizoma zingiberis.
20 clinical test of embodiment
1 clinical data
1.1 diagnostic criteria
Meet the clinical criteria of " chloasma " of the formulation of the Chinese Association of Chinese and Western Medicine Dermatology committee.
1.2 inclusion criteria
(1) meet diagnostic criteria；
(2) age 18~45 years old；
(3) without pigmentation caused by other skin diseases or other diseases；
(4) patient agrees to this research therapeutic scheme and signs informed consent form.
1.3 exclusion criteria
(1) other skin diseases such as leucoderma, psoriasis, lupus erythematosus；
(2) the important organs insufficiency such as serious conscience kidney；
(3) diseases such as complication with diabetes, tumour, myocardial infarction；
(4) gestation or nursing period；
(5) there are the history of medications such as glucocorticoid, immunosuppressor in (4 weeks) in the recent period.
1.4 general information
160 women patient with chloasma of our hospital's diagnosis and treatment, meet above-mentioned standard.
4 groups are randomly divided into according to the random parallel method of dividision into groups, the no significant differences such as age, course of disease of 4 groups of patients are poor
Different (P ＞ 0.05), is comparable.
1.5 therapy
4 groups of patients give psychological intervention, and patient is helped to establish correctly treatment sight, viewpoint of disease, psychological pressure is discongested, disappears
Except unhealthy emotion, scientific and effective diet, life and movement intervention plan are formulated, mitigates caused by irregular living habit interior point
Imbalance is secreted, the method for instructing patient's self-control is finally reached the purpose that body and mind loosens.
A groups：The Chinese medicine composition of embodiment 1 is given, is added water to cook, a point morning and evening takes twice, 1 dose/day.
B groups：The Chinese medicine composition of comparative example 1 is given, is added water to cook, a point morning and evening takes twice, 1 dose/day.
C groups：The Chinese medicine composition of comparative example 2 is given, is added water to cook, a point morning and evening takes twice, 1 dose/day.
D groups：It gives vitamin C and takes orally 300mg, 3 times/day, natural VE takes orally 100mg, 3 times/day.
More than 4 groups of patients continuously treat 8 weeks be 1 course for the treatment of, judge curative effect after the course for the treatment of.
1.6 deliberated index
1.6.1 color spot area and the scoring of spot color
(1) color spot area：It is denoted as 3 points of (color spot area ＞ 4cm successively according to color spot size2), 2 points of (color spot areas 2
~4cm2), 1 point of (color spot area ＜ 2cm2), 0 point (no color spot)；
(2) spot color scores：According to color spot shade be denoted as successively 3 points (dark browns), 2 points (brown), 1 point it is (shallow brown
Color), 0 point (normal skin tone).
1.6.2 efficacy assessment standard
It is basic to cure：Facial colour spot area recession >=90%, this disappearance of spot color base, other simultaneous phenomenons are clearly better；
It is effective：Facial colour spot area recession >=60% but ＜ 90%, spot color is significantly thin out, other simultaneous phenomenons have inclination
Turn；
Effectively：Facial colour spot area recession >=30% but ＜ 60%, spot discoloration is light, other simultaneous phenomenons improve or without change
Change；
In vain：Facial colour spot area recession ＜ 30%, this is even aggravated spot color base without improvement, other simultaneous phenomenons are without good
Turn.
2 results
2.1 color spot areas and the scoring of spot color are compared
4 groups of pretherapy and post-treatment color spot areas and spot color scoring comparison result are shown in Tables 1 and 2.
1 color spot area of table compares (cm2)
The scoring of 2 spot color of table is compared
2.2 Clinical efficacy comparison
4 groups of pretherapy and post-treatment Clinical efficacy comparisons of patient the results are shown in Table 3.
3 Clinical efficacy comparison of table
21 animal experiment of embodiment
1 material
Regular grade Kunming kind female mice, 18~22g of weight.
2 methods
2.1 experimental animals are grouped
Mouse is randomly divided into 9 groups, every group 10.
A groups：Normal group, give 0.5ml/ days/time of physiological saline/only
B groups：Model control group, give 0.5ml/ days/time of physiological saline/only
C groups：Decoction is made in 1 Chinese medicine composition of comparative example, and 0.5ml/ days/time/, dosage is Chinese medicinal material 11g/kg.
D groups：Decoction is made in 2 Chinese medicine composition of comparative example, and 0.5ml/ days/time/, dosage is Chinese medicinal material 11g/kg.
E groups：Decoction is made in 3 Chinese medicine composition of comparative example, and 0.5ml/ days/time/, dosage is Chinese medicinal material 11g/kg.
F groups：Decoction is made in 1 Chinese medicine composition of embodiment, and 0.5ml/ days/time/, dosage is Chinese medicinal material 11g/kg.
G groups：Decoction is made in 6 Chinese medicine composition of embodiment, and 0.5ml/ days/time/, dosage is Chinese medicinal material 11g/kg.
H groups：Decoction is made in 15 Chinese medicine composition of embodiment, and 0.5ml/ days/time/, dosage is Chinese medicinal material 11g/kg.
I groups：Western medicine group, Ascorbyl C pill are pulverized, and are dissolved in 0.5ml distilled water
Administering mode is gavage, and administration Deal with Time is 4 weeks.
2.2 animal models make
Each group experiment mice back is lost hair or feathers, bare area about 2cm × 2cm, is lost hair or feathers 1 time weekly.In addition to Normal group,
His each group experimental animal irradiates mouse 1 time daily with the ultraviolet B radiation of wavelength 320nm, irradiation time about 20 minutes, animal
Distance with light source is 20cm.Continuous irradiation 4 weeks.
2.3 index determining
2.3.1 materials
8th weekend of experiment, the depilation of experiment mice back instrument, area about 2cm × 2cm.
(1) blood is taken：Eyeball excise method takes blood, about takes 3~5ml blood；Test tube label, centrifuge, 3000~
4000rpm takes serum, carries out SOD in serum according to kit specification instruction step and MDA is detected.
(2) skin is taken：After the disconnected neck of experiment mice whole for taking blood is put to death, holostrome skin at the depilation of back is removed immediately
Skin (is free of subcutaneous fat), and it is to be measured to be frozen in preservation in -70 DEG C of refrigerators.
2.3.2 the preparation of skin histology homogenate
(1) each mice skin tissue sample takes 0.5g, is rinsed in ice physiological saline, removes blood, wiped with filter paper it is dry,
Tissue block is shredded as possible with small cut of ophthalmology, and the tissue shredded is poured into glass homogenate tube.
(2) 4.5ml cold salines are measured with graduated cylinder, pours into homogenizer and be fully homogenized.
(3) slurries are centrifuged 10 minutes with the speed of 4000rpm.
(4) supernatant is taken, is operated by SOD kits and the stringent by specification of MDA kits, carries out index determining.
3 results
SOD activity influences the results are shown in Table 4 in 3.1 each group mouse skins and serum.
The influence of SOD activity in 4 skin of table and serum
The influence result table 5 of MDA contents in 3.2 each group mouse skins and serum.
The influence of MDA contents in 5 skin of table and serum
22 decoction of embodiment
The Chinese medicine composition of embodiment 1~19 adds water to cook, and obtains soup.
23 granule of embodiment
The Chinese medicine composition of embodiment 1~19 adds water to cook 3 times, merging filtrate, be concentrated into relative density be 1.1 it is clear
Cream.Clear cream adds in ethyl alcohol, stands 24 hours, and ethyl alcohol is recycled in filtration, is concentrated into the thick paste that relative density is 1.2.Thick paste is sprayed
Mist is dried, and get dry extract fine powder.Dry cream fine powder is added in into dextrin, is uniformly mixed, pelletizes according to a conventional method, it is dry, granule is made.
24 dispersible tablet of embodiment
The Chinese medicine composition of embodiment 1~19 adds water to cook 3 times, merging filtrate, be concentrated into relative density be 1.1 it is clear
Cream.Clear cream is spray-dried, and obtains dry cream fine powder.Dry cream fine powder is uniformly mixed with sodium carboxymethyl starch, microcrystalline cellulose,
It pelletizes according to a conventional method, it is dry, magnesium stearate, silica, mixing are added in, dispersible tablet is made in tabletting according to a conventional method.
25 capsule of embodiment
The Chinese medicine composition of embodiment 1~19 adds water to cook 3 times, merging filtrate, be concentrated into relative density be 1.15 it is clear
Cream.Clear cream is spray-dried, and obtains dry cream fine powder.Magnesium stearate, talcum powder are added in, mixing adds in hollow according to a conventional method
Capsule is made in capsule.
26 pill of embodiment
The Chinese medicine composition of embodiment 1~19 adds water to cook 3 times, merging filtrate, be concentrated into relative density be 1.18 it is clear
Cream.Clear cream is spray-dried, and obtains fine powder.Suitable quantity of water or/and yellow rice wine are added in, water-bindered pill agent is made.Or add in ethanol in proper amount and
Softwood is made in soybean oil, and softwood pellet pellet processing machine pill is dry, and pellet is made in sieving.Or using polyethylene glycol as matrix, two
Methyl-silicone oil is condensate liquid, and pill is made in dripping pelletization.
27 oral liquid of embodiment
The Chinese medicine composition of embodiment 1~19 adds water to cook 3 times, merging filtrate, be concentrated into relative density be 1.1 it is clear
Cream.Clear cream adds in ethyl alcohol, stands 24 hours, and ethyl alcohol is recycled in filtration, is concentrated into the thick paste that relative density is 1.2.According to a conventional method
Stevioside is taken to be dissolved in pure water, sodium benzoate, purified water is added in, is uniformly mixed with thick paste, oral liquid is made.
28 powder of embodiment
The Chinese medicine composition of embodiment 1~19 is ground into smalls with pulverizer.Then sieving throws the fine powder after sieving
Enter the abundant mixing of mixing and blending machine, obtain powder.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, under the premise of the method for the present invention is not departed from, can also make several improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (5)
1. a kind of Chinese medicine composition of eliminating chloasma, which is characterized in that the Chinese medicine composition by following parts by weight original
Material medicine is made：10~20 parts of radix bupleuri, 7~13 parts of Radix Codonopsis, 4~8 parts of Rhizoma Chuanxiong, sweet 10~20 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 20~40 parts of jujube,
6~12 parts of radix scutellariae, 2~4 parts of Radix Glycyrrhizae, sweet 10~20 parts of bran stir-baked RADIX PAEONIAE ALBA, 10~20 parts of rhizoma alismatis, 6~12 parts of the tuber of pinellia processed, Radix Angelicae Sinensis 7~
11 parts, 10~20 parts of PORIA ALBA, 4~8 parts of rhizoma zingiberis.
2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition is by following parts by weight
Bulk pharmaceutical chemicals are made：13~17 parts of radix bupleuri, 9~11 parts of Radix Codonopsis, 5~7 parts of Rhizoma Chuanxiong, sweet 13~17 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, jujube 25~35
Part, 8~10 parts of radix scutellariae, 2.5~3.5 parts of Radix Glycyrrhizae, sweet 13~17 parts of bran stir-baked RADIX PAEONIAE ALBA, 13~17 parts of rhizoma alismatis, 8~10 parts of the tuber of pinellia processed,
8~10 parts of Radix Angelicae Sinensis, 13~17 parts of PORIA ALBA, 5~7 parts of rhizoma zingiberis.
3. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition is by following parts by weight
Bulk pharmaceutical chemicals are made：15 parts of radix bupleuri, 10 parts of Radix Codonopsis, 6 parts of Rhizoma Chuanxiong, sweet 15 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 30 parts of jujube, 9 parts of radix scutellariae, 3 parts of Radix Glycyrrhizae,
Sweet 15 parts of bran stir-baked RADIX PAEONIAE ALBA, 15 parts of rhizoma alismatis, 9 parts of the tuber of pinellia processed, 9 parts of Radix Angelicae Sinensis, 15 parts of PORIA ALBA, 6 parts of rhizoma zingiberis.
4. according to any Chinese medicine composition of claims 1 to 3 in the drug or health products for preparing eliminating chloasma
Using.
5. application according to claim 4, which is characterized in that the drug is oral drugs.
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| CN108514632A (en) * | 2018-07-03 | 2018-09-11 | 谢洁如 | A kind of Chinese medicine composition and preparation method thereof for treating chloasma |
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| JPH0449217A (en) * | 1990-06-18 | 1992-02-18 | Sansho Seiyaku Co Ltd | External preparation of suppressing melanogenesis |
| CN101125119A (en) * | 2007-07-18 | 2008-02-20 | 西藏宇妥藏药研究有限公司 | Tibetan materia medica with whitening anti-senility function and application thereof |
| CN107183274A (en) * | 2017-06-16 | 2017-09-22 | 李俊云 | Blood-nourishing is soothing the liver cosmetic tea and preparation method thereof and application method |
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| JPH0449217A (en) * | 1990-06-18 | 1992-02-18 | Sansho Seiyaku Co Ltd | External preparation of suppressing melanogenesis |
| CN101125119A (en) * | 2007-07-18 | 2008-02-20 | 西藏宇妥藏药研究有限公司 | Tibetan materia medica with whitening anti-senility function and application thereof |
| CN107183274A (en) * | 2017-06-16 | 2017-09-22 | 李俊云 | Blood-nourishing is soothing the liver cosmetic tea and preparation method thereof and application method |
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| CN108514632A (en) * | 2018-07-03 | 2018-09-11 | 谢洁如 | A kind of Chinese medicine composition and preparation method thereof for treating chloasma |
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