KR20060030575A - Pharmaceutical composition comprising the complex crude drug extract for preventing and treating hyperthyroidism - Google Patents

Abstract

The present invention relates to a composition for improving hyperthyroidism containing herbal extracts, and more specifically, lobular, ginseng, Astragalus, Angelica, celestial organ, gyeji, thick, white paper, windproof, oak, betel nut, white peach, crust, mokyang, The present invention relates to a pharmaceutical composition for the prevention and treatment of hyperthyroidism, which contains a complex herbal extract consisting of licorice and gilyeong extract. The composition of the present invention is useful in medicines and health functional foods for the prevention and treatment of hyperthyroidism because it is stable to the human body while alleviating symptoms such as exophthalmos, hyperthyroidism, arrhythmia and the like caused by hyperthyroidism Can be.

Hyperthyroidism, lobules, pharmaceutical compositions

Description

Pharmaceutical composition comprising the complex crude drug extract for preventing and treating hyperthyroidism}

Pharmaceutics for the prevention and treatment of hyperthyroidism containing complex herbal extracts consisting of lobular, ginseng, Astragalus, Angelica, celestial, gyeji, hoobak, white paper, windproof, oak, betel nut, white peony, crust, cedar, licorice and gil dynasty It relates to a composition.

The thyroid gland is an endocrine gland below the anterior thyroid cartilage of the larynx. Its main function is the production of thyroxine, the thyroid hormone. Thyroxine is involved in the regulation of carbohydrates, proteins and fats, and also enhances the function of growth hormone.

Hyperthyroidism is a disease in which the function of the thyroid gland is increased due to a pathological increase in the function of the thyroid gland.The thyroid gland produces excessive amounts of thyroid hormone, which increases the concentration of thyroid hormone in the blood. It refers to a change in nature. Occurs in women in their 20s and 50s, with 5% of children being children. The cause is most often due to autoimmune disease, Bajes 'disease (or Graves' disease), but in addition to addictive nodular goiter (plumer's disease), thyroid-stimulating hormone gland of the pituitary gland, thyroid cancer, painless thyroiditis or subacute thyroiditis Appears on The more thyroid hormones in the blood, the greater the metabolism, which makes the body warmer and more sensitive to external temperatures. Therefore, you can not stand the heat, sweat a lot, and the appetite increases, but the weight continues to decrease, usually between 1 to 2 months by 3 to 4kg. The pulse is faster, the chest is pounding, and an arrhythmia occurs, which causes irregular pulses. Your skin becomes warm and moist, and you may feel foreign body pain or pain in your neck. In addition, the nerves are nervous, nervous, and always feel tired. If you can't sleep well, your hands are trembling, your limbs are weak, and you are paralyzed. Menstrual cycles may become irregular, the amount may decrease, or even menstruation may stop. On the other hand, the front of the neck with the thyroid gland may protrude or, in severe cases, the eye may protrude.

For the treatment of hyperthyroidism, radioactive iodine is used to suppress thyroid function or, in severe cases, to remove the thyroid gland through surgical surgery.

Perilla frutescens BRITT (perilla frutes), an annual herb of Lacaceae, is called foliar and seed in medicinal plants, and essential oil of the entire lobular. Ingredients include arginine, cumic acid, cyanidin-3- (6-p-cue, in addition to about 55% perylaldehyde, 20-30% l-limonene and small amounts of α-pinene. Maroyl- [beta] -D-glucoside) -5- [beta] -D-glucoside, and the refined fat and oil component of the leaf contains isoeegoma ketone. Used as a sweat, antitussive, dry, diuretic, soothing and analgesic. Small stems are old stems of the lobules and the roots of the lobules, which are effective in combating gout, sweating and expectoration, lowering the qi, dizziness, body pain and nasal congestion, It is effective in treating a runny nose (Information and Sinmin-kyo Ilbo Herbal Medicine Dictionary, Younglimsa, pp855-856, 1998).

Panax ginseng (Panax ginseng) is a perennial plant root of the genus Araliaceae in the plant taxonomy and has been used as a valuable remedy since ancient times. Through many pharmacological experiments, Panax ginseng enhances the nonspecific resistance of the body to stress and its anti-acid action. Turned out to have. Saponin, the main ingredient of the impression, is a mixture of 13 or more saponins and has various biological activities. Its effects include strengthening cerebral cortex excitability and suppression process, antistress effect, improvement of hypertension symptoms, insulin action, hypoglycemic effect in alloxan diabetic mouse, liver RNA synthesis in rats, protein Synthesis, sugar and lipid metabolism promoting effect, and anti-cancer effect is known (Information and Shin Mingyo, medicinal herb, Yeonglimsa, pp439-442, 1998).

Astragalus membranaceus (FISCH.) BGE is a perennial herb, used to dry roots, and contains glucuronic acid, proteins, several amino acids, and folic acid as active ingredients. Astragalus has a cardiovascular effect, dilates coronary or systemic peripheral blood vessels, lowers blood pressure and diuretic. In addition, it protects the liver and has the effect of preventing hepatic glycogen reduction, sedation, uterine contraction, and blood sugar reduction (Jung Bo-seop and Shin, Min-Kyo; Hyang-Jung-Dae, Yeonglimsa, pp662-664, 1998).

Angelica (Angelica acutiloba (S. et Z.) KITAGAWA) is a naturalized plants that are grown in Korea, Japan and the origin of 60 to 90cm in height perennial, flowers hangs on the branches at the end of August to September in white, Fruits Are long oval flat and have narrow wings at the edges. The root is called Angelica, which has the effect of blood, so there is no blood on the face, dizziness is frequent, and it is known to be effective for people who have no gloss on eyes and lips. Headache is weak body, women's menstrual control effect is excellent, so it is often used in various prenatal and postpartum diseases, and it treats menstrual irregularities and abdominal pain. It is effective in treating constipation due to weak gastrointestinal function (Bae Ki-hwan), color guidebook for health guidelines according to folk remedies and herbal remedies, pp102-103, 2003.

Cheongung (川芎) is a perennial herb belonging to umbelliferae, and in oriental medicine, its root stem is dried and is mainly used for gynecological diseases such as headache, infertility, menstrual irregularity, anemia, tonic, and coldness. The chemical components of the horoscope include phthalide-based compounds such as cnidilide, neocnidilide, ligustilide, butylphthalide and senkyunolide. (Fuzita M. and Kobayashi M . ; Chem. Pharm. Bull., 35 (4), pp1427-1433, 1987).

Ginji (Cinnamomi Ramulus) means that the branches of the broiler tree ( Cinnamomun loureirii NEES) are cut to 15cm in length and dried in the sun, and is used as a herbal medicine. Taste is sour and gentle in nature. It radiates the richness of the mark, and reaches the limbs, making meridians more painful and articulating. Make it happen. The action of all over the body has the effect of active blood circulation and acidic pain, so it has an external feeling of cold (풍 感 痛), abundant humidity ratio (寒濕 痺) and menopause (經 閉), It is used to treat symptoms such as pain and pain. It also contains 0.07% alkaloids, 2.06% saponins, 2.51% tannins, and essential oils (Jung Bo-seop and Shin-Kyomin, Pharmacology, Yeonglimsa, p455,1998).

Hupak is a dried perennial herb, Magnolia officinalis REHD. Et WILS, and the related bark of the genus Magnoliaceae . It is known to have the efficacy of anti-retrograde (降 逆 平喘). Thickening includes β-eudesmol, magnool, magnolol, honokiol, magnocurarine, tannin, etc. And it is effective in the treatment of abdominal pain, bloating, acute enteritis, seawater, etc. (Bo Bo-seop and Shin Min-gyo, Hyangjeomsa, Yeonglimsa, pp469-471,1998).

White paper removes the roots of perennial herbaceous copper roots and similar green plants, and removes the roots of roots and dries them in the sun. Byak-angelicin, byak-angelicol, and oxy It has ingredients such as oxypeucedanin, torin, torsoimperatorin, and pepopteropterin. It has antibacterial action against E. coli, cholera, etc., and it has an excitement effect on the peristaltic, respiratory, vagus nerve and spinal cord of blood vessels of other animals, so that it raises blood pressure, slows down low pressure and takes deep breaths. It is effective in treating non-yeon, damp-abdominal pain, and skin dryness (Bo Bo-seop and Shin Min-kyo, Hyang-dae metabolism, Younglimsa, pp409-410, 1998).

Windproof ( Ledebouriella seseloides WOLF.) Is used to dry the roots of the three-year-old herb, Umbelliferae. , Sweating, sea area, analgesic, diuretic (Bo Bo-seop and Shin Mingyo, Hyangjeomsa, Yeonglimsa, p428, 1998).

Spilled dried roots of Lindera Stryc-hnifolia belonging to the family Lauraceae. Linderane, Linderene , Linderenol, Lindestrene Etc. are contained. Aromatic stomach, analgesic, analgesic, effective in the treatment of abdominal pain, abdominal infection, hari, nervous gastritis, vomiting, frequent urination, dysmenorrhea (Hu, SL, Chi, Q., Zhao, Z, Heilongjiang Science & Technology Press, Harbin) , pp 331-333, 1989).

Betel nut ( Areca catechu L.) is a seed of the betel nut belonging to the palm family (Palmae) is used in the sun dried, contains 0.3-0.6% alkaloids, 15% condensed tannins, 14% fat and Areca red. It is effective in insecticidal, loquat, Hagi, and Haengsu (Jung Bo-seop and Shin Mingyo, Hyangjedae, Yeonglimsa, pp272-274, 1998).

Paeonia japonica (MAKINO) MIYABE et TAKEDA is a perennial herb that is less than 50cm tall and blooms in May-June. In autumn, care roots and beard roots are removed, washed and dried. Root contains 1.8 ~ 7.3% of paeoniflorin and root bark contains 1 ~ 1.1%. In addition, it contains essential oils, fatty oils, resins, tannins, sugars, and mucus. Paeniflorin of Count is effective in antifungal and menstrual pain in addition to soothing analgesic and anti-inflammatory effects (Bo Bo-seop, Shin Min-gyo, Hyangjeomsa, Younglimsa, pp524-525, 1998)

Crust is an immature fruit just before the maturation of Tangerine and Tangerine trees belonging to the Rutaceae. It is dried and used.

Mok-hyang is a perennial herb that is a perennial herb that is used to dry the roots of the perennial herb, and the same roots of plants in the sun, and aflotaxene, α-ionone, and β-celinene ( essential oils such as selinene, costol and camphene, and stigmasterol, inulin, and the like. It is associated with the action of relieving stomach pain in the gastrointestinal tract, increasing blood pressure, inhibiting the heart by expanding peripheral blood vessels, and has antibacterial effects (Jung Bo-seop and Shin Min-kyo, Ph.D., Yeonglimsa, pp1066-1068, 1998 ).

Licorice ( Glycyrrhiza uralensis FISCH.) Is a perennial herb, which is a herbaceous perennial herb. It is used as a drug, and itself has a weakness such as neutralization of poison. For example, licorice has the effect of protecting the liver and smoothing the liver and regulating fatigue, and taking licorice reduces the burden on the liver by its detoxification. Triterpene-based saponins and glycyrrhizin are contained in the roots and roots of plants, so they have all detoxification effects on bacterial toxins as well as drug addiction, food poisoning, and metabolism in the body. There is a function and regulation of thyroid sebum hormone. Licorice has anti-inflammatory and anti-allergic reactions, antagonistic action against acetylcholine, and a potent effect of adrenaline stimulation. 1998).

Gil-Gi is used to dry the roots of perennial herbaceous bellflower, which belongs to the Companulaceae, in the sun, contains saponins, platydigenin, glucose, α-spinasterol, and betulin. ), Inulin and the like. Gilkyung has a good expectorant action because it promotes the secretion of organs and reduces the amount of bile (Jung Bo-seop and Shin Min-kyo, Hyangjeomsa, Yeonglimsa, p1089, 1998).

As mentioned above, lobules, ginseng, Astragalus, Angelica, Cheongung, Gyeji, Hakbak, White Paper, Windproof, Yakja, Betel, Peony, Crust, Mokji, Licorice and Gilkyong have been used in traditional medicine and folk medicine without special toxicity or side effects. In the meantime, many studies on the efficacy and toxicity of each have been done scientifically. However, there is no research literature or other data about the composition for improving hyperthyroidism containing the herbal extract as well as the study itself.

Therefore, the present inventors have searched for herbal medicines to improve thyroid dysfunction and improve the usability as medicines. The above-mentioned lobules, ginseng, Astragalus, Angelica, Cheongung, Gyeji, hakbak, white paper, windproof, oak, betel nut It is confirmed that the herb extract of sixteen organic extracts containing herbal medicine, earl, crust, neck, licorice and gilyeong show excellent effects on the relief of symptoms such as ocular prolapse, hyperthyroidism and arrhythmia caused by hyperthyroidism. Was completed.

An object of the present invention is a hyperthyroidism containing a complex herbal extract consisting of lobule, ginseng, Astragalus, Angelica, celcius, lanceolate, vulgaris, white paper, windproof, oak, betel nut, baekjak, crust, cedar, licorice and Giltyeong as an active ingredient. It provides a pharmaceutical composition and health functional food for the prevention or treatment of.

In order to achieve the above object, the present invention is a composite herbal extract consisting of lobule, ginseng, Astragalus, Angelica, cheonggung, gyeji, hakbak, baekji, windproof, oak, betel nut, baekjak, crust, mokyang, licorice and Gilyeong as an active ingredient Provided is a pharmaceutical composition for the prevention or treatment of hypothyroidism, comprising a pharmaceutically acceptable carrier, excipient or diluent.

The extract includes a polar solvent selected from water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, preferably an extract available in water.

Hereinafter, the present invention will be described in more detail.

The extract is characterized in that it is included in the form of a pulverized product, extract or powder extract thereof. At this time, the composition according to the present invention includes a mixed extract comprising a single extract of each herbal medicine, or a complex extract prepared by extracting a plant containing two or more of each herbal medicine.

The extract according to the present invention may be a crude extract prepared by applying a solvent extraction method using a conventional water extract, alcohol, etc. as a solvent, and may also be a fraction extract purified using column chromatography. Extraction method according to the invention can be applied to all extraction methods known to those of ordinary skill in the art, for example, extraction with water, alcohol or mixed solvents, extraction method using a bath or room temperature, etc. Including but not limited to.

In a preferred embodiment of the present invention, dried herbal medicines may be washed to remove foreign substances, etc. present on the surface of the material, and then dried in a dryer, mixed in an appropriate blending ratio, and ground to obtain the herbal powders. In addition, 1 to 20 times volume / weight of distilled water, lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, preferably about 1 to 20 times, and most preferably about 3 to 10 times With water, cold soaking, hot water extraction, ultrasonic extraction, reflux cooling extraction, preferably refluxing at 20-100 ° C., preferably at 50-70 ° C. for about 1 hour to 10 days, preferably about 2 to 5 hours. The extract obtained by using the cooling extraction method is filtered and concentrated under reduced pressure to obtain a water extract.                     

Extract of the present invention is not limited to this, leaflets, ginseng, Astragalus, Angelica, cheonggung, gyeji, bakbak, white paper, windproof, five-oak, betel nut, white peony, crust, mokyang, licorice and Giltyeong based on the dry weight of each herbal medicine 1.5 ~ 4: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 It is preferable to contain in the ratio of -1.5: 0.5-1.5: 0.5-1.5: 0.2-1. The herbal extracts have been used as food for a long time as the extract of the present invention extracted therefrom also has no problems such as toxicity and side effects.

The herbal extract prepared by the above method is administered to a patient diagnosed with hyperthyroidism for a long time and is administered for thyroid function control, thereby alleviating symptoms such as exophthalmos, hyperthyroidism, and arrhythmia.

The present invention comprises a composite herbal extract consisting of the lobule, ginseng, Astragalus, Angelica, cheongung, gyeji, thick, white paper, windproof, oak, betel nut, baekjak, crust, mokyang, licorice and gilyeong as an active ingredient and pharmaceutically acceptable Provided is a pharmaceutical composition for preventing or treating hypothyroidism, including a possible carrier, excipient, or diluent.

The pharmaceutical composition for preventing or treating hypothyroidism of the present invention comprises 0.01 to 50% by weight of the extract based on the total weight of the composition.

Pharmaceutical dosage forms of the extracts of the present invention may be used in the form of their pharmaceutically acceptable salts, or may be used alone or in combination with other pharmaceutically active compounds, as well as in a suitable collection.

Pharmaceutical compositions comprising extracts according to the invention, in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral preparations, suppositories and sterile injectable solutions, respectively, according to conventional methods. Can be formulated and used. Carriers, excipients and diluents that may be included in the composition comprising the extract include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate , Cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. When formulated, diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, and surfactants are usually used. Solid preparations for oral administration include tablets, pills, powders, granules, capsules and the like, and such solid preparations may include at least one excipient such as starch, calcium carbonate and sucrose in the extract. ) Or lactose, gelatin and the like are mixed. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Oral liquid preparations include suspensions, solvents, emulsions, and syrups, and may include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin. . Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories. As the non-aqueous solvent and suspending agent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate and the like can be used. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.

Preferred dosages of the extracts of the present invention vary depending on the condition and weight of the patient, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art. However, for the desired effect, the extract or compound of the present invention is preferably administered at 10 to 2000 mg / kg, preferably at 100 to 1000 mg / kg. Administration may be administered once a day or may be divided several times. The pharmaceutical composition of the present invention can be administered to various mammals such as rats, mice, livestock, humans, and the like. All modes of administration can be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intrauterine dural or cerebrovascular injections.

Complex herbal extract of the present invention is a drug that can be used with confidence even when taken for a long time for the purpose of prevention because there is little toxicity and side effects.

The present invention is a composite herbal extract consisting of leaflets, ginseng, Astragalus, Angelica, cheonggung, gyeji, hakbak, white paper, windbreak, oak, betel nut, white peony, crust, neck scent, licorice and Giltyeong, showing the prevention effect of hypothyroidism. It provides a dietary supplement comprising a food supplement containing a food supplement acceptable. The dietary supplement of the present invention includes the form of tablets, capsules, pills or liquids.                     

In addition, the compound herbal extract consisting of leaflets, ginseng, Astragalus, Angelica, celestial organs, ginseng, thick pepper, white paper, windproof, oak, betel nut, white pear, crust, neck, licorice, and gil dynasty is a food or beverage for the purpose of preventing hypothyroidism. The food type is not particularly limited, and for example, various foods such as sweets, breads, noodles, and the like, drinks such as water, soft drinks, fruit drinks, gums, teas, vitamin complexes, seasonings, etc. And dietary supplements. At this time, the amount of the extract or compound in the food or beverage, in general, in the case of the health functional food composition of the present invention can be added to 0.01 to 15% by weight, preferably 0.1 to 5% by weight of the total food weight, health drink The composition may be added at a ratio of 0.01 to 30 g, preferably 0.1 to 1 g based on 100 ml. Since the health functional food of this invention obtained in this way contains the composition of this invention, it is a food which can fully utilize the health prevention effect and health treatment effect which the compound of this invention has.

Food supplement additives as defined herein include food additives customary in the art, such as flavorings, flavoring agents, colorants, fillers, stabilizers, and the like, and are exemplified below.

The health beverage composition of the present invention has no particular limitation on the liquid component except for containing the extract or compound as essential ingredients in the indicated proportions, and may contain various flavors or natural carbohydrates, etc. as additional ingredients, like ordinary beverages. Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And conventional sugars such as polysaccharides such as dextrin, cyclodextrin, and sugar alcohols such as xylitol, sorbitol, erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example rebaudioside A, glycyrrhizin, etc.), and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The proportion of natural carbohydrates is generally about 1-20g, preferably about 5-12g per 100ml of the composition of the present invention.

The food of this invention is easily obtained by adding the process of adding the composition of this invention mentioned above to the manufacturing process of the base food, or by adding the process of adding the composition of this invention mentioned above after manufacture of the foodstuff which is a base material. Can be. At this time, a taste and odor correction agent may be added as needed.

In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese, chocolate), pectic acid and salts thereof, alginic acid and its Salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. The compositions of the present invention may also contain pulp for the production of natural fruit juices and fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical but is generally selected from the range of 0 to about 20 parts by weight per 100 parts by weight of the composition of the present invention.

Hereinafter, the present invention will be described in detail by Examples and Experimental Examples.                     

However, the following Examples and Experimental Examples are only illustrative of the present invention, and the content of the present invention is not limited to the following Examples and Experimental Examples.

Example 1. Preparation of Complex Herbal Extract

12g, ginseng, dried leaf, ginseng, rhubarb, donkey, cheongung, gyeji, hubak, white paper, windproof, oak, betel nut Astragalus, Angelica, Cheongung, Cheongji, Thuak, White Paper, Windproof, Yakja, Betel, Count, Peony, Crust, Mokyang, Licorice each 4g and 2g of Gilyeong are added together to 2L of water, and 3 hours each on a water bath using a reflux condenser. Extracted once. The extract was filtered on a filter paper and then concentrated under reduced pressure to obtain a water extract of 19.8 g (yield 28.3%) to be used as a sample.

Experimental Example 1. Clinical Experiment

1-1. 30-year-old woman who had been diagnosed with hyperthyroidism since 1 year ago and had been treated at the hospital, but complained of exophthalmos, shortness of breath, tremors, and palpitations of the present invention. As a result of taking the combined herbal extract of Example 1 for 20 days, it was confirmed that the above symptoms were alleviated.

1-2. 40-year-old woman: a patient suffering from a goiter with a chestnut-like tumor touched for 40 days with the herbal extract of Example 1 of the present invention, the size of the goiter was confirmed to be reduced.

1-3. 22-year-old woman: Twenty years ago, a patient with thyroid poisoning, thyroid enlargement, exophthalmos, palpitations, and psychotic irritation who took the complex herbal extract of Example 1 of the present invention for 40 days. This was alleviated, the enlarged thyroid gland was reduced and the above symptoms disappeared.

Experimental Example 2. Toxicity Test

In order to investigate the presence or absence of toxicity by the oral administration of the extract of Example 1 to the rat male and female rats of the 1 g / kg, 2 g / kg and 5 g / kg three doses of 5 The animals were orally administered once and observed for 14 days of death, general symptoms, weight change and autopsy findings. The result of this test is as follows.

(1) There were no deaths observed during the entire test period in all administration groups of the composition of the present invention during the test period, and there was no change in general symptoms specifically observed compared to the control group.

(2) Body weight change showed significant weight loss on day 3 after administration in 5 g / kg dose group, but was not different from control group in all other administration groups.

As a result, no clinical symptoms were observed in all the test substance-treated groups compared to the death and control groups, and there were almost no specific symptoms in the anatomical changes at the time of body weight and autopsy. In addition, since the composition did not show a clear toxicity at the dose of 5 g / kg or less, LD ₅₀ (lethal dose) in rats by oral administration is determined to be more than 5 g / kg.

Hereinafter, the formulation examples of the pharmaceutical preparations will be described, which are intended to explain in detail only, not to limit the present invention.

Formulation Example 1 Preparation of Injection

Extract of Example 1 ............................ 1.0 mg

Sodium metabisulfite ........ 3.0mg

Methylparaben ............... 0.8 mg

Propylparaben ...................... 0.1 mg

Sterile distilled water for injection ..............

The above ingredients are mixed and made into 2 ml by a conventional method, and then filled into 2 ml ampoules and sterilized to prepare an injection.

Formulation Example 2 Preparation of Tablet

Extract of Example 1 ...................................... 20 mg

Lactose 100 mg

Starch .............................. 100 mg                     

Magnesium Stearate ...............

The above components are mixed and tableted according to a conventional method for producing tablets to produce tablets.

Formulation Example 3 Preparation of Capsule

Extract of Example 1 ............................ 10 mg

Lactose 50 mg

Starch ........................................ 50 mg

Talc ........................................ 2mg

Magnesium Stearate ...............

Capsules are prepared by mixing the above ingredients and filling into gelatin capsules according to a conventional method for preparing capsules.

Formulation Example 4 Preparation of Liquid

Extract of Example 1 .................. 100 mg

Sugar .................................. 20g

Isomerized sugar ......................................... 20 g

Lemon Flavor ......................

Purified water is added to the whole ........... 100ml

The above components are mixed according to a conventional method for preparing a liquid, filled into a 100 ml brown bottle, and sterilized to prepare a liquid.

Formulation Example 5 Preparation of Healthy Food

Extract of Example 1 ...................................... 1000 mg

Vitamin Mixture ......................

Vitamin A Acetate ......... 70 μg

Vitamin E ................................... 1.0 mg

Vitamin B ₁ ................................. 0.13 mg

Vitamin B ₂ ................................. 0.15 mg

Vitamin B ₆ ....................... 0.5 mg

Vitamin B ₁₂ ................................. 0.2 μg

Vitamin C ......................................... 10 mg

Biotin ......................................... 10 μg

Nicotinamide ........................................ 1.7 mg

Folic acid ......................................... 50 ㎍

Calcium Pantothenate ......................................... 0.5 mg

Inorganic mixtures ...............

Ferrous Sulfate ......... 1.75 mg

Zinc Oxide ..... 0.82 mg                     

Magnesium Carbonate ............... 25.3 mg

Potassium monophosphate ......................................... 15 mg

Dibasic calcium phosphate ............ 55 mg

Potassium Citrate ..... 90 mg

Calcium Carbonate ... 100 mg

Magnesium Chloride ............... 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixtures is mixed with a component suitable for a health food in a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional health food manufacturing method. The granules may be prepared and used for preparing a health food composition according to a conventional method.

Formulation Example 6 Preparation of Healthy Drink

Extract of Example 1 ..................... 1000 mg

Citric Acid .................................... 1000 mg

Oligosaccharide ........................... 100 g

Plum concentrate ........................... 2 g

Taurine ......................................... 1 g

Purified water is added .............. 900 ml total

After mixing the above components in accordance with a conventional healthy beverage production method, and stirred and heated at 85 ℃ for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2 L container, sealed sterilization and then refrigerated and stored in the present invention For the preparation of healthy beverage compositions.

Although the composition ratio is a composition suitable for a preferred beverage in a preferred embodiment, the composition ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, use purpose.

The herbal extract of the present invention consisting of leaflets, ginseng, Astragalus, Angelica, celestial organs, gyeji, thick, white paper, windproof, oak, betel nut, white baekjak, crust, neck, licorice and Giltyeong extract of the eye caused by hyperthyroidism, To reduce the symptoms of hyperthyroidism, arrhythmia and the like, it can be usefully used as a pharmaceutical composition and health functional food for the prevention or treatment of hyperthyroidism.

Claims (5)

A medicinal acceptable carrier, excipient comprising a compound herbal extract consisting of lobular, ginseng, Astragalus, Angelica, celcius, lanceolate, white leaf, white paper, windproof, oak, betel nut, white peony, crust, cedar, licorice and gilgon Or a pharmaceutical composition for preventing or treating hyperthyroidism comprising a diluent. According to claim 1, The compound herbal extract is leaf, ginseng, Astragalus, Angelica, cheonggung, gyeji, hakbak, white paper, windproof, oak, betel nut, white peony, crust, mokyang, licorice and Giltyeong based on the dry weight of each herbal medicine 1.5 ~ 4: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 ~ 1.5: 0.5 to 1.5: 0.5 to 1.5: 0.2 to 1 in the pharmaceutical composition characterized in that it contains a ratio. The pharmaceutical composition according to claim 1 or 2, wherein the extract is soluble in a polar solvent selected from water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof. It contains as an active ingredient a complex herbal extract consisting of lobules, ginseng, Astragalus, Angelica, celcius, ginseng, black pepper, white paper, windbreak, oak, betel nut, white peony, crust, cedar, licorice and gil dynasty, which show the preventive effect of hyperthyroidism. Nutraceuticals comprising food acceptable food supplement additives. The health functional food according to claim 4, wherein the health functional food is a tablet, a capsule, a pill or a liquid.