CN103041309A

CN103041309A - Beauty folium ginkgo oral liquid and preparation method thereof

Info

Publication number: CN103041309A
Application number: CN2012105943455A
Authority: CN
Inventors: 杨高林
Original assignee: Qingdao Huaren Information Technology Development Co Ltd
Current assignee: Zhouzhi County Tianyi Biological Science And Technology Co ltd
Priority date: 2012-12-31
Filing date: 2012-12-31
Publication date: 2013-04-17
Anticipated expiration: 2032-12-31
Also published as: CN103041309B

Abstract

The invention relates to a beauty folium ginkgo oral liquid. The beauty oral liquid comprises raw materials as follows: folium ginkgo, leonurus, radix angelicae, Chinese angelica, rhizoma bletillae, radix salviae miltiorrhizae, poria cocos, peach blossom, radix curcumae, glossy privet fruit, pot marigold, Chinese trumpet creeper, scutellaria baicalensis, radix paeoniae alba, white atractylodes rhizome, albizia flower, propolis and caulis spatholobi. The ginkgol biloba extract has strong free radical scavenging and antioxidation effects, and the flavonol, amino acid and amino acid synthesized collagen ingredient in the folium ginkgo have important roles of beautifying human bodies, inhibiting the growth of melanin and maintaining luster and elasticity of the skin and the beauty folium ginkgo oral liquid is suitable for long-term use. According to the invention, the defect of toxicity of the folium ginkgo is overcome, the active ingredients of the folium ginkgo are greatly retained, secondary pollution is avoided in the production, and the beauty folium ginkgo oral liquid is a complete green, healthy and environment-friendly health-care product; and the natural Chinese medicines, which can activate blood and remove stasis, tonify qi and activate blood, tonify qi and lift yang, sooth liver-qi stagnation, calm liver and suppress yang, enrich yin and nourish kidney and clear away heat and toxic material, are added, so that the effects of strengthening body resistance and eliminating evil, improving intestinal function and excreting more poisonous substances of a body, and activating blood and removing stasis are achieved, the blood circulation and liver detoxification capabilities of human bodies are improved, and the effect of beautifying the skin is achieved.

Description

A kind of Folium Ginkgo oral liquid for beauty and preparation method thereof

Technical field

The present invention relates to contain the cosmetic health product that derives from plant composition, particularly a kind of Folium Ginkgo oral liquid for beauty and preparation method thereof.

Background technology

Folium Ginkgo is a kind of plant with very high medical value, and ginkgo is one of ancient seeds of China, and it is the tree of the medical treatment of mystery, Jurassic Period dinosaur control terrestrial time before more than 200,000,000 5 thousand year, and Semen Ginkgo is one of the most flouring plant.Life on earth is gone through the change in 100000000000 years, especially after the glacier covering of the 4th century, only has Semen Ginkgo still to keep its most original looks, is called as " living fossil " in the organic evolution history.Its leaf, fruit, seed have higher medical value, and its pharmacological action constantly is familiar with, and clinical application range progressively enlarges.Ginkgo has another name called maidenhair tree, is the rarity of China, and is rare valuable, is described as " hollywood lignumvitae ", " living fossil " of the earth.

Modern people's living and diet is too meticulous, and quantity of motion reduces, or eating and drinking too much at one meal, or overstrain, so that the body metabolism function fails gradually, causes visceral dysfunction, causes easily the pigmented lesions such as chloasma faciei, freckle.The traditional Chinese medical science thinks that facial colour spot is uncomfortable because of the internal organs meridian qi and blood, and blood deficiency is not dissolved in face; Or because of internal injury caused by excess of seven emotions, stagnation of QI due to depression of the liver, incoordination between the liver and spleen; Or because of improper diet and overtiredness, menoxenia; Or because of the blood system of fire stagnation meridians, ailment said due to cold or exposure is rich and due to sending out outward.Adopt this class disease of western medicine, be mostly outer wiping or vitamins for oral administration, flavonols medicine.Because pathogenesis is more, adopt the western medicine effect to differ, also be difficult for radical cure, some medicine side effect is larger.

Contain the multiple components useful with health such as natural activity flavone and amarolide in the Folium Ginkgo, has dissolving cholesterol, the effect of blood vessel dilating has positive effect to improving disordered brain function, arteriosclerosis, hypertension, dizzy, tinnitus, headache, senile dementia, hypomnesis etc.Its diseases prevention, cure the disease, the value of body-building is early on the books in the Compendium of Material Medica of Ming Dynasty's Li Shizhen (1518-1593 A.D.).Detect proof through national health department: drink Folium Ginkgo tea and can obviously reduce serum cholesterol, triglyceride and low-density blood lipoprotein, reduce the effect of depot lipid in the body.For fat-reducing of the complementary controls of diseases of cardiovascular and cerebrovascular systems patient such as adjusting, hypertension and the coronary heart disease of hyperlipidemia and obese type crowd etc. good effect being arranged, is the desirable beverage of prophylactic treatment senile dementia.It is the optimal pharmaceutical compositions of cardiovascular and cerebrovascular disease of controlling, prevent recognized in the world.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Though Folium Ginkgo energy blood circulation promoting, the prevention cardiovascular diseases, but can not take simultaneously other and control cardiovascular drugs (for example aspirin), Semen Ginkgo extrac has very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, the check melanin growth keeps skin gloss and elasticity to play no small effect.In addition, according to modern clinical research, the chronic schizophrenia take negative symptoms as main (such as social withdrawal, sluggishness, the poverty of thought, the symptom such as dull) there is remarkable result, cerebellar atrophy (senile dementia) is also had certain effect.

The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, the old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting the blood coagulation situation, not the blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel more can not long-term taking, in order to avoid cause cerebral hemorrhage.Folium Ginkgo can not together brew up with Folium Camelliae sinensis and Flos Chrysanthemi.

Although the ginkgo Leaves health care effect is very strong, Folium Ginkgo contains poisonous composition, and brewing up with it to cause clonospasm, neural paralysis, platycoria, allergy and other side effect.Anemia of pregnant woman and child, old man are careful.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.Semen Ginkgo contains a large amount of ginkgoic acids, ginkgoic acid be contain virose, the leaf of generally buying does not pass through deep processing and extraction, the ginkgoic acid content of the inside is up to 3000-4000ppm, special ginkgoic acid is water miscible, one soaked Semen Ginkgo pyrite and the active substance such as Semen Ginkgo lactone of not only not having the inside, effect is opposite on the contrary, the inside is poison entirely.

Although the ginkgo Leaves health care effect is very strong, Folium Ginkgo contains poisonous composition, and brewing up with it to cause clonospasm, neural paralysis, platycoria, allergy and other side effect.Ginkgoic acid, improper use or dosage are too large, are easy to cause poisoning.So at present in the urgent need to a kind of technique, health-care effect that can the application Folium Ginkgo makes again its poisonous material drop to minimum.Anemia of pregnant woman and child, old man are careful.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.But anemia of pregnant woman of the present invention and child, old man are careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, the old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting the blood coagulation situation, not the blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel more can not long-term taking, in order to avoid cause cerebral hemorrhage.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.

Summary of the invention

There are a lot of defectives in prior art, and Folium Ginkgo contains poisonous composition, and brewing up with it to cause clonospasm, neural paralysis, platycoria, allergy and other side effect; A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.Semen Ginkgo extrac has very strong removing free radical and antioxidation, and the synthetic collagen Proteins of yellow glycoside, aminoacid and the aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.The invention solves the virose shortcoming of Folium Ginkgo; And the beneficiating ingredient that has kept greatly Folium Ginkgo makes it not have work in-process to run off, and has on the make avoided secondary pollution, is the health product of green health environmental protection fully.Add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body improves blood circulation of human body and liver detoxification ability, reaches the effect that beautifies skin.

For solving above-mentioned technical barrier, the invention provides a kind of Folium Ginkgo oral liquid for beauty, the parts by weight of various raw materials are in the described Folium Ginkgo oral liquid for beauty: 10～30 parts of Folium Ginkgos, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Poria, 10～20 parts in Flos persicae, 10～20 parts of Radix Curcumaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Flos Inulaes, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Flos Albiziaes, 10～20 parts of propolis, 10～20 parts of Caulis Spatholobis.

Described Folium Ginkgo oral liquid for beauty, the parts by weight of various raw materials can also be preferably in its described Folium Ginkgo oral liquid for beauty: 10～30 parts of Folium Ginkgos, 10～15 parts of Herba Leonuris, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts in Poria, 10～15 parts in Flos persicae, 10～15 parts of Radix Curcumaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Flos Inulaes, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Flos Albiziaes, 10～20 parts of propolis, 10～20 parts of Caulis Spatholobis.

Described Semen Ginkgo oral liquid for beauty, the parts by weight of various raw materials also can be preferably in its described Folium Ginkgo oral liquid for beauty: 10～30 parts of Folium Ginkgos, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Poria, 10～20 parts in Flos persicae, 10～20 parts of Radix Curcumaes, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Flos Inulaes, 10～15 parts of Flos Campsiss, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Flos Albiziaes, 10～15 parts of propolis, 10～15 parts of Caulis Spatholobis.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Folium Ginkgo oral liquid for beauty, and the preparation method of described Folium Ginkgo oral liquid for beauty may further comprise the steps:

A. the Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into unguentum;

E. surplus stock is made unguentum;

F. it is canned after being in harmonious proportion to add dextrin after unguentum obtained above and the Folium Ginkgo extract unguentum of making being mixed by the part by weight of 2:1.

Among the described step a, can get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 8-12h takes out and places cooling in the drying baker, pulverizes 80 mesh sieves with pulverizer, and powder places brown wide mouthed bottle to store.

Among the described step b, can get and be made into 60% alcoholic solution; Then fall ginkgo leaf powder in 60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 700mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.

Among the described step c, ginkgo biloba succi can be used first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed; The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, after the sucking filtration end, gets filtrate and abandons filtering residue.

In the described steps d, distillation, concentrating appts can be installed, contain a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and be condensed into particulate matter or paste object.

Among the described step e, surplus stock can be put into 10 times of amount ethanol, heating and refluxing extraction 2 times each 1～2 hour, leaves standstill 2 extracting solution merging; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged, 1.36 o'clock filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, and extractum reduces pressure to get.

Among the described step f, it is canned after being in harmonious proportion to add dextrin after the extractum that abovementioned steps can be made the Folium Ginkgo extract that extractum and above-mentioned steps make mixes.

Semen Ginkgo extrac has very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, the check melanin growth, keep skin gloss and elasticity to play no small effect, be fit to long-term taking, can not damage health.The invention solves the virose shortcoming of Folium Ginkgo; And the beneficiating ingredient that has kept greatly Folium Ginkgo makes it not have work in-process to run off, and has on the make avoided secondary pollution, is the health product of green health environmental protection fully.Add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body improves blood circulation of human body and liver detoxification ability, reaches the effect that beautifies skin.

The specific embodiment

Traditional Chinese medical science QI and blood theory is thought, the qi-blood circulating process is the material base that all histoorgans of human body carry out work, the smooth balance of QI-blood circulating regularly is expensive, will not produce blood stasis if QI and blood is smooth, blood stasis hinders in body, will further cause the deterioration of qi-blood circulating, cause more serious stasis of blood plug, so the traditional Chinese medical science take QI and blood as guiding principle, makes it smooth balance by regulating qi and activating blood, but disease-relieving and physique enhancing, the beauty treatment of nourishing blood.Skin speckle at all in the stasis of blood, moving back speckle must first blood stasis dispelling, blood stasis dispelling be when invigorating blood circulation, invigorating blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood moves thereupon; Blood is keeping of gas, be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy is blood prostration then, gas is compeled then blood and is walked.QI and blood and then all and.And regulate the flow of vital energy liver, QI invigorating is at the lung kidney, lung governing skin and hair.Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, the mottles such as chloasma, freckle occur and cause face, even alopecia, alopecia areata occur.The present invention mainly identifies and corrects according to Chinese medicine and executes the principle of controlling, and the many doctor chiefs of family of collection skim the cream off milk; Based on pathogenetic understanding and the Therapeutic Principle of Chinese medicine to facial colour spot, reference is Chinese medicine pharmacological research achievement at all times, the natural Chinese medicine of screening inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body, improve blood circulation of human body and liver detoxification ability, reach the effect that beautifies skin.Semen Ginkgo extrac has very strong removing free radical and antioxidation, and the synthetic collagen Proteins of yellow glycoside, aminoacid and the aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.

The Mineral Concentrations such as VC, VE, carotene and calcium, phosphorus, boron, selenium are also very abundant in the Folium Ginkgo, surpass general fruit and vegetable and edible plant raw material.Biological anti-oxidant is a class material that directly and indirectly has anti-oxidation function in the body.In Folium Ginkgo, contain two class antioxidants--nutrient antioxidant and non-nutritive antioxidant.The former mainly contains carotene, VC, VE, selenium, zinc, copper etc.; the latter mainly contains ginkgetin, terpene lactones, catechin, Polyphenols etc.; content is also very abundant, and they are not subjected to have ten important effects aspect the oxidative damage due to the free radical at the protection body.Therefore, Folium Ginkgo integrates nutrition, health care, treatment function, and Folium Ginkgo is developed as the resource that high nutrition, health care are worth, and this is significant for improving the Folium Ginkgo comprehensive utilization ratio.The development and use of Folium Ginkgo are from the thirties in 20th century, and Japan and West Germany have namely begun the research of Folium Ginkgo.Along with deepening continuously of modern pharmacological research, to find not only to contain Flavonoid substances in the Folium Ginkgo, and also have the chemical compounds such as terpene lactones, phenols, the pharmacological action of their brilliances is familiar with gradually by people.Clinical observation proves that Folium Ginkgo has following several effect: 1, reduce cholesterol levels in the blood of human body, prevent arteriosclerosis.To be short of physical strength behind the middle-aged and elderly people light activity, palpitating speed, chest pain, the effect of being significantly improved such as feel dizzy.2, reduce blood pressure by increasing the saturating property of blood vessel and elasticity, preferably antihypertensive effect is arranged.3, the deposition composition on the elimination blood vessel wall improves blood flow and changes, and promotes erythrocyte deformability, and blood viscosity lowering makes blood flow unobstructed, can prevent and treat cerebral hemorrhage and cerebral infarction.The senile dementia that arteriosclerosis is caused also has certain curative effect.Gingko leaf preparation and antidiabetic drug share the treatment diabetes good therapeutic effect, can be used for the adjuvant of diabetes.5, can obviously alleviate the symptoms such as abdominal pain in menstruation and sore waist and aching in the waist and the back.6, be used for the treatment of bronchial asthma, good therapeutic effect is also arranged.7, reduce level of lipid, reduce freckle, moist skin, beautiful appearance.8, relieving constipation, diuresis, toxin expelling, detoxifcation.9, climacteric syndrome is improved significantly.

Anemia of pregnant woman of the present invention and child, old man are careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, the old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting the blood coagulation situation, not the blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel more can not long-term taking, in order to avoid cause cerebral hemorrhage.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.

The Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, dispel silt, regulating menstruation, water disappears.The treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, rushes down blood, the carbuncle skin infection at hematuria.Herba Leonuri contains the materials such as leonurine, Fumaric acid, and the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema are arranged.

Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Be used for hemoptysis and spit blood traumatic hemorrhage, sore swollen toxin, chapped skin; The pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in the stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: suffering, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control the conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood is mended fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, and evacuation of pus, desolation, scabies, the pain relieving granulation promoting is gone face Shao-defect scar.

The Flos Inulae nature and flavor are light flat, and flower, leaf have antiinflammatory, antibacterial action.Root energy promoting flow of QI and blood, but removing heat from blood, hemostasis spent.Superpower healing ability, sterilization convergence wound is administered inflammation, skin sore, corse sweat pore prevents the generation of cicatrix.The calm skin of energy improves the sensitivity skin quality.Effect with maintenance cicatrix.Can promote the metabolism of skin.Especially for the skin of drying, the moisturizing effect of height is arranged.Radix Curcumae is hot, bitter, and is cold.Return liver, the heart, lung meridian.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.Promoting QI circulation for relieving depression, the removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, it is demented to lose the heart, and the calentura coma is spitted blood epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman's stagnated blood epigastric pain caused by emotional factors, the cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound.

A kind of Chinese medicine material of Flos Campsis has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature is returned liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, control the key medicine of pain in the blood also, and the nourishing YIN victory very, be stamped and keep and walk alone, in the married woman side multiplex what." Nanning City's medicine will ": the merit of eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting is arranged, control red Hakuri.

Flos Albiziae contains the Herba Albiziae glycoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain is used for irritability, melancholy insomnia.It is uncomfortable in chest to control pent-up, and insomnia is forgetful, and acute conjunctivitis can settling five organs, and will, improving healthy complexion, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.Also has clearing away summer-heat, the face-beautifying and spot-removing effect such as relieve the effect of alcohol." book on Chinese herbal medicine warp " said: " Flos Albiziae energy settling five organs, and will, improving healthy complexion." especially to the anemia of pregnant woman, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration to be that the treatment blood stasis is not loose, the good medicine that nourishing blood silt is invigorated blood circulation

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to usefulness, controls early whitening of beard and hair, often joins the same usefulness of Fructus Mori, and Cortex Lycii is often joined in fever due to yin deficiency.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, hepatic injury to Carbon Tetrachloride Induced has obvious protective effect, and can promote liver cell regeneration. and oleanolic acid also can make in the liver triglyceride accumulate that minimizings, hepatocellular degeneration necrosis obviously alleviate, glycogen is accumulated increase, serum γglobulin decline; Mitochondrial swelling and the degeneration of endoplasmic reticulum vesicle alleviates, the matter inflammatory reaction weakens between hepatic tissue in the visible hepatocyte of ultrastructure.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Poria sweet in the mouth, light, property are flat, be used as medicine have promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.The Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.Has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, the edema distension, the phlegm retention cough with dyspnea, vomiting, malignant histocytosis is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria reaches by strong activating the spleen pulmonary function, and is different from the Chinese medicine of other direct diuretic.Be used for diarrhea due to hypofunction of the spleen, the leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, for have loose bowels due to the insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, use the effect that Poria has giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as the tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Eca109), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Remarkable inhibitory action is also arranged." property of medicine opinion " carries it: monarch, and sweet in the mouth, suffering, nontoxic.Can main large migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, sputum is removed in appetizing, except cold and heat, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and the insufficiency of stomach-QI cold-dysentery.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, the lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.The Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.

Propolis (bee glue) have the good reputation of " blood vessel street cleaner ", what the recent domestic scholar did studies show that in a large number, flavonoid in the propolis (flavonoid) composition and various active composition, can improve elasticity and the permeability of blood vessel, vasodilator is removed the overstocked thing of depositing of blood vessel, purify the blood, blood fat reducing, blood viscosity lowering improves and organizes microcirculating state, and the effect that has stronger antioxidation, removes free radical.The toxicological experiment result shows that propolis is actual innocuous substance, is safe and feasible by the prevention of long-term taking propolis and treatment hyperlipemia therefore.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, really the gas medicine in the blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain relieving constipation of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Specific embodiment 1:

Preparation: get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 9h (it is fixed that the time is looked the sample moisture, can 8～12h), and take out and place cooling in the drying baker, pulverized 80 mesh sieves with pulverizer, powder places brown wide mouthed bottle to store.

Lixiviate: prepare 60% alcoholic solution (get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution).Get the 100g ginkgo leaf powder in 700mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 700mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.

Sucking filtration: use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing.

Distillation, concentrated: distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.A certain amount of ethanol also has bactericidal action, when measuring the extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, and ethanol is volatilized totally fully.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.Can take simple method, direct heating in water bath, the ethanol that in air, volatilizees, this method shortcoming: can not Recycled ethanol.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.

Dry: owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, and utilization increases vacuum and reduces boiling point, removes last ethanol and residual part moisture.If conditions permit can also adopt freezing and drying lyophilization dry.Except containing flavonoid and lactone, also contain a certain amount of impurity in the extract of this moment.

All the other raw materials are granulated: with all the other raw material Herba Leonuris, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Salviae Miltiorrhizae, Poria, Flos persicae, Radix Curcumae, Fructus Ligustri Lucidi, Flos Inulae, Flos Campsis, Radix Scutellariae, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Flos Albiziae, propolis, Caulis Spatholobi.

Packing: with the above-mentioned extractum that makes, the Folium Ginkgo extract good with aforementioned dry in the sun mixes, and adds an amount of dextrin and is in harmonious proportion, and be canned.

Specific embodiment 2:

Pluck the fresh and tender Folium Ginkgo of 1000g, clean, dry, in 70 ℃ of baking ovens, baking 10h takes out and places cooling in the drying baker, pulverizes 60 mesh sieves with pulverizer, and powder places brown wide mouthed bottle storage preparation 60% alcoholic solution.Get the 1000g ginkgo leaf powder in 7000mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 7000mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.Use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing, and contains a large amount of alcoholic solution in the sucking filtration liquid, carries out ethanol with distilling apparatus and concentrates.A certain amount of ethanol also has bactericidal action, when measuring the extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, and ethanol is volatilized totally fully.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.Can take simple method, direct heating in water bath, the ethanol that in air, volatilizees, this method shortcoming: can not Recycled ethanol.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.Owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilizes increase vacuum to reduce boiling point, removes last ethanol and residual part moisture.With all the other raw material Herba Leonuri 500g, Radix Angelicae Dahuricae 500g, Radix Angelicae Sinensis 500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 500g, Radix Salviae Miltiorrhizae 500g, Poria 500g, Flos persicae 500g, Radix Curcumae 500g, Fructus Ligustri Lucidi 500g, Flos Inulae 500g, Flos Campsis 500g, Radix Scutellariae 500g, Radix Paeoniae Alba 500g, Rhizoma Atractylodis Macrocephalae 500g, Flos Albiziae 500g, propolis 500g, Caulis Spatholobi 500g.Put it in 10 times of amount ethanol, heating and refluxing extraction 2 times each 1～2 hour, leaves standstill 2 extracting solution merging; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged, and the concentrating under reduced pressure relative density is the filtrate of 1.36 (80 ℃), and Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, and extractum reduces pressure to get; Then the Folium Ginkgo extract extractum that obtains with above-mentioned steps adds an amount of dextrin and is in harmonious proportion, and is canned.

Specific embodiment 3:

Pluck the 500g Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 9h takes out and places cooling in the drying baker, pulverized 60 mesh sieves with pulverizer, powder places brown wide mouthed bottle storage preparation 60% alcoholic solution (get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution).Get the 500g ginkgo leaf powder in 3500mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 3500mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.Use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing.Distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.Owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilizes increase vacuum to reduce boiling point, removes last ethanol and residual part moisture.With all the other raw material Herba Leonuri 210g, Radix Angelicae Dahuricae 220g, Radix Angelicae Sinensis 230g, Pseudobulbus Bletillae (Rhizoma Bletillae) 210g, Radix Salviae Miltiorrhizae 220g, Poria 230g, Flos persicae 240g, Radix Curcumae 210g, Fructus Ligustri Lucidi 250g, Flos Inulae 220g, Flos Campsis 210g, Radix Scutellariae 230g, Radix Paeoniae Alba 240g, Rhizoma Atractylodis Macrocephalae 210g, Flos Albiziae 230g, propolis 250g, Caulis Spatholobi 220g.Put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, add 8-10 times of water gaging for the first time and decocted 1-2 hour, add 4-8 times of water gaging for the second time and decocted 1-2 hour, merge decocting liquid twice, filter to get filtrate; Heating is concentrated into pasty state, and the Folium Ginkgo extract extractum that then obtains with above-mentioned steps adds an amount of dextrin and is in harmonious proportion, and is canned.

Pharmacology's toxicity test

Health product acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: health product of the present invention contain 0.0365g crude drug/g.

Two, method:

1, LD50 calculates: adopt the improvement karber's method, mice is divided into 5 groups at random, 10 every group, male and female half and half with adding distil water dissolving of the present invention, are made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18,14.4 to dosage by the crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, at twice administration in one day (interval half an hour), each 0.5ml observes the animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.With adding distil water of the present invention dissolving, be made into maximum concentration, by the maximum tolerated dose of animal, fill with injection and to feed device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, at twice feedwater (interval half an hour) in a day, each 0.5ml (every ml contains crude drug 0.036g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation is 7 days after the administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, there are no death.Namely select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD＞18g/Kg.d.

Long term toxicity test data of the present invention

Chinese medicine of the present invention is through 6 months long-term toxicity test for animals result of gastric infusion: the SD rat is divided into three groups, 30 every group, male and female half and half (being divided into high, medium and low three dosage groups, 10 every group), wherein first group through gavage to normal saline; Second group is given dosage of the present invention through gavage is 0.25g, 2.5g and 12.5g/kg.d; The 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of lovastatin.During administration, observe respectively that clinical manifestation, hematology, blood after each treated animal administration is biochemical, the indexs such as organ coefficient and histopathology carry out the evaluation of drug toxicity.Result of study: main toxic reaction shows lovastatin 50mg/kg.d and 5.0mg group, shows after the administration that reaction and the symptoms such as sialorrhea, hair are fluffy, busy, diarrhoea, step have appearred in the SD rat, total food ration with lose weight; Blood test shows that total white blood cells increases to some extent, erythrocyte sum, content of hemoglobin and platelet count obviously descend (P all＜0.05); Blood biochemistry checking shows that ALT, AST, ALP and CK raise 1～8 times (P all＜0.05), and creatinine and blood urea nitrogen raise (P all＜0.05) to some extent, but do not cause animal dead; Histopathological analysis result shows that the Liver and kidney pathological change similar to the people appearred in lovastatin 50mg/kg.d group.And similar reaction does not all appear in three dosage groups of normal saline group and 0.25g of the present invention, 2.5g and 12.5g/kg.d and lovastatin 0.5mg/kg.d dosage group during whole administration, at the convalescent period viewing duration, the symptom that each treated animal of reaction the occurs recovery normal condition that fades away.As seen the present invention not only can reduce the toxic and side effects of lovastatin, and can make the clinical non-toxic of lovastatin increase to 5～25 times (P all＜0.01).

The test of pesticide effectiveness:

1 materials and methods

1.1 material: animal grouping and modeling, gavage Therapeutic Method

Get 60 of female Kunming mouses, be divided at random 6 groups, 10 every group.45 days modeling time, 45 days treatment times of gavage.White mice is provided by biology department of University Of Qingdao breeding center.

1. normal group: with 10%NaS ₂Aqueous solution is sloughed back wool, exposes 1 of skin, the about 1.5cm * 1.5cm of area.Lose hair or feathers once weekly intramuscular injection every day water for injection, 5ml/kg body weight.The depilation position change of skin situation of Continuous Observation mice.After 45 days, stop modeling, every day gavage deionized water 0.6ml.

2. model group: process with the normal group depilation, inject 0.4% Progesterone every day, the 5ml/kg body weight.Place special constraint bucket in constraint with mice every day, and fettering the simultaneously irradiation of the ultraviolet B radiation (UVB) take wavelength as 320nm mice 1 time, constraint irradiation time 60min, Continuous Observation.After 45 days, stop modeling, every day gavage deionized water 0.6ml.

3. positive controls (the XIAOYAO POWDER treatment group, 3.43g/kg): process with normal group depilation, inject 0.4% Progesterone every day, the 5ml/kg body weight.Place special constraint bucket in constraint with mice every day, and fettering the simultaneously irradiation of the ultraviolet B radiation (UVB) take wavelength as 320nm mice 1 time, constraint irradiation time 60min, Continuous Observation.After 45 days, stop modeling, every day gavage XIAOYAO POWDER 0.6ml.

4. high dose group of the present invention (14.19g/kg): process with the normal group depilation, inject 0.4% Progesterone every day, the 5ml/kg body weight.Place special constraint bucket in constraint with mice every day, and fettering the simultaneously irradiation of the ultraviolet B radiation (UVB) take wavelength as 320nm mice 1 time, constraint irradiation time 60min, Continuous Observation.After 45 days, stop modeling, every day gavage compositions 0.9ml.

5. middle dosage group of the present invention (9.46g/kg): process with the normal group depilation, inject 0.4% Progesterone every day, the 5ml/kg body weight.Place special constraint bucket in constraint with mice every day, and fettering the simultaneously irradiation of the ultraviolet B radiation (UVB) take wavelength as 320nm mice 1 time, constraint irradiation time 60min, Continuous Observation.After 45 days, stop modeling, every day gavage compositions 0.6ml.

6. low dose group of the present invention (4.73g/kg): process with the normal group depilation, inject 0.4% Progesterone every day, the 5ml/kg body weight.Place special constraint bucket in constraint with mice every day, and fettering the simultaneously irradiation of the ultraviolet B radiation (UVB) take wavelength as 320nm mice 1 time, constraint irradiation time 60min, Continuous Observation.After 45 days, stop modeling, every day gavage compositions 0.3ml.

2, test method

2.2 skin, liver MDA, SOD, ZnCu-SOD determination of activity adopt test kit to detect MDA, SOD activity, experiment is carried out to specifications.

2.3 the mensuration of total SOD (T-SOD) vigor: requirement to specifications, carrying out preliminary experiment, to calculate optimum sample size be 30ul.Successively add the tissue homogenate of reagent 1～4 and 1%, with the abundant mixing of swirl mixing device, put 37 ℃ of waters bath with thermostatic control 40 minutes.Then add developer 2ml mixing, pour into after 10 minutes in the 1cm optical path cuvette, distilled water zeroing, wavelength 550nm place colorimetric.

2.4CuZn-SOD the mensuration of vigor: get the reagent seven that tissue homogenate 0.2ml adds 0.1ml,, with 3500-4000 rev/mins, centrifugal 15 minutes, get supernatant and test after 1 minute with the abundant mixing of swirl mixing device.Method is with total SOD.

2.5MDA the mensuration of vigor: requirement to specifications, the tissue homogenate that successively adds reagent 1～3 and 1%, the swirl mixing device mixing, the test tube mouth is tightened with antistaling film, stings an aperture, 95 ℃ of water-baths 40 minutes, flowing water cooling after taking out, then 3500～4000 rev/mins, centrifugal 10 minutes, (centrifugation time below 3000 rev/mins need prolong, and purpose makes precipitation fully).Get supernatant 0.1ml, the 532nm place, the 1cm optical path, the distilled water zeroing, colorimetric is surveyed and is respectively managed absorbance.

2.6HMB45 the PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM of the dermal melanin cell of labelling

1) routine paraffin wax embedded section (5um) dewaxes to water.Distilled water flushing, PBS soaked 5 minutes.2) 3%H2O2 incubated at room 5-10 minute, to eliminate the activity of endogenous peroxydase, PBS flushing, 2 minutes * 3 times.3) 10% normal goats serum sealing, incubated at room 10 minutes drips primary antibodie HMB45, and 4 ℃ are spent the night.4) PBS flushing, 2 minutes * 3 times.Drip the biotin labeling two anti-(1%BSA-PBS dilution) of proper proportion dilution, 37 degree were hatched 10-30 minute; 5) PBS flushing, 2 minutes * 3 times.Drip the Radix Cochleariae officinalis enzyme labelling strepto-avidin (PBS dilution) of proper proportion dilution, 37 degree were hatched 10-30 minute; 6) PBS flushing, * was 3 times in 2 minutes.Chromogenic reagent (DAB) 5-10 minute.7) tap water fully washes, and haematoxylin is redyed, and transparent, mounting dewaters.Adopt Image-Pro Plus5.0 image analysis system software analysis, calculate area and the optical density of respectively organizing melanocyte and melanin granule positive expression position.

2.6 the expression of dermal melanin cell NOS

1) routine paraffin wax embedded section (5um) dewaxes to water.Distilled water flushing, PBS soaked 5 minutes.2) 3%H2O2 incubated at room 5-10 minute, to eliminate the activity of endogenous peroxydase, PBS flushing, 2 minutes * 3 times.3) 10% normal goats serum sealing, incubated at room 10 minutes drips primary antibodie NOS, and 4 ℃ are spent the night.4) PBS flushing, 2 minutes * 3 times.Drip the biotin labeling two anti-(1%BSA-PBS dilution) of proper proportion dilution, 37 degree were hatched 10-30 minute; 5) PBS flushing, 2 minutes * 3 times.Drip the Radix Cochleariae officinalis enzyme labelling strepto-avidin (PBS dilution) of proper proportion dilution, 37 degree were hatched 10-30 minute; 6) PBS flushing, 2 minutes * 3 times.Chromogenic reagent (DAB) 5-10 minute.7) tap water fully washes, and haematoxylin is redyed, and transparent, mounting dewaters.Adopt Image-Pro Plus5.0 image analysis system software analysis, calculate area and the optical density of respectively organizing NOS positive expression position.

3, experimental data

3.1 mensuration and the statistics of the total SOD activity of skin

With the contrast of blank group, the total SOD activity value of the skin of high dose group of the present invention descends, and has significant difference; Dosage group low dosage there are differences with blank group among XIAOYAO POWDER, the present invention.With the model group contrast, XIAOYAO POWDER, the present invention's height, middle dosage group have extremely significant difference, and there were significant differences for low dose group.See Table 1.As seen ultraviolet+Progesterone method active decline of the total SOD of mouse model skin of setting up, it is active that XIAOYAO POWDER, the high, medium and low dosage of the present invention all can improve the total SOD of skin, and wherein high, the middle dosage treatment of XIAOYAO POWDER, the present invention has extremely significantly effect.

The variation of the total SOD activity of table 1 skin (x ± s ,/mg albumen)

Annotate: compare * P＜0.05, * * P＜0.01 with the blank group; Compare ★ P＜0.05, ★ ★ P＜0.01 with model group.Liver F=4.624, skin F=5.010

3.2 mensuration and the statistics of liver ZuCu-SOD activity

With the contrast of blank group, the liver ZuCu of low dose group of the present invention-SOD activity value descends, and has significant difference.With the model group contrast, treatment XIAOYAO POWDER, high dose group of the present invention have significant difference.See Table 2.As seen the chloasma mouse model liver ZuCu of chronic constraint+ultraviolet+Progesterone method foundation-SOD is active descends, it is active that XIAOYAO POWDER, the high, medium and low dosage of the present invention all can improve liver ZuCu-SOD, and wherein XIAOYAO POWDER, high dose of the present invention have significant therapeutical effect.

3.3 mensuration and the statistics of skin ZuCu-SOD activity

Descend with the skin ZuCu of blank group edition with parallel text invention low dose group-SOD activity value, have significant difference.With the model group contrast, the dosage group has significant difference among treatment XIAOYAO POWDER, the present invention.See Table 2.As seen the chloasma mouse model skin ZuCu of chronic constraint+ultraviolet+Progesterone method foundation-SOD is active descends, it is active that XIAOYAO POWDER, the high, medium and low dosage of the present invention all can improve skin ZuCu-SOD, and wherein dosage has significant therapeutical effect in XIAOYAO POWDER, the compositions.

The variation (x ± s ,/mg albumen) of table 2ZuCu-SOD activity

Annotate: compare * P＜0.05, * * P＜0.01 with the blank group; Compare ★ P＜0.05, ★ ★ P＜0.01 with model group.Liver F=3.395, skin F=6.804.

3.4HMB45 the dermal melanin cell pathology morphological observation of labelling

3.4.1HMB45 the whole observation of the dermal melanin cell of labelling

Normal group: squamous epithelial cancer is more poor, formed by basal cell and the spine cell of marshalling, and layer 2-3 altogether, there is a small amount of cutin on the surface.See hair follicle in the corium, sebaceous gland links to each other with epidermis, has no sweat gland.It is special that subcutaneus adipose tissue has no.Almost have no melanocyte in the HMB 45 labelling epidermises, see a small amount of melanocyte in hair follicle, the sebaceous gland basal cell.

The melanin positive cell showed increased of model group: HMB 45 labellings, with the blank group utmost point significant difference is arranged, cluster is distributed in the hair follicle basal cell group, is strong positive reaction, also see the single melanocyte that is dispersed in distribution in epidermal basal cell and the prickle cell layer, companion cell nuclear increases and examines and move.The epidermis cell number increases, and the part is verrucous hyperplasia.Treatment group: show substantially same model group, the melanin positive cell reduces, there were significant differences with model group, and the liver energy stagnation type chloasma mouse model dermal melanin cell compared with normal mice of pointing out chronic constraint+ultraviolet+Progesterone method to set up is significantly increased, and XIAOYAO POWDER and compositions have therapeutical effect.

The variation of melanin granule positive area in the mouse skin melanocyte of table 3HMB45 labelling

Annotate: compare * P＜0.05, * * P＜0.01 with the blank group; Compare ★ P＜0.05, ★ ★ P＜0.01 with model group.The F=61.170 of positive area, the F=14.096 of IOD, the F=11.896 of MOD.

As seen from Table 3:

(1) the positive area compared with normal group of melanin granule significantly raise (P＜0.01) in the mouse skin melanocyte of model group HMB45 labelling, XIAOYAO POWDER, each dosage treatment group of compositions have downward trend, wherein XIAOYAO POWDER treatment group and compositions low dose group decline highly significant (P＜0.01), combination object height, the downward trend of middle dosage group are not obvious.

(2) the IOD compared with normal group of melanin granule significantly raise (P＜0.01) in the mouse skin melanocyte of model group HMB45 labelling, XIAOYAO POWDER, each dosage treatment group of the present invention have downward trend, wherein XIAOYAO POWDER treatment group and high dose group decline highly significant of the present invention (P＜0.01).

(3) the MOD compared with normal group of melanin granule significantly raise (P＜0.01) in the mouse skin melanocyte of model group HMB45 labelling, XIAOYAO POWDER, each dosage treatment group of the present invention have downward trend, XIAOYAO POWDER treatment group decline highly significant (P＜0.01) wherein, dosage group descend obviously (P＜0.05) among the present invention.The downward trend of compositions high and low dose group is not obvious.

In sum, positive area, IOD, the MOD of melanin granule all have significant rising in the mouse skin melanocyte of model group HMB45 labelling, XIAOYAO POWDER, each dosage treatment group of the present invention have downward trend, but in general, the effect of high dose group of the present invention is the most remarkable, positive area, IOD, MOD are all had significant reducing effect, secondly are dosage groups among the present invention.

Conclusion: Semen Ginkgo extrac has very strong removing free radical and antioxidation, and the synthetic collagen Proteins of yellow glycoside, aminoacid and the aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.Add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body improves blood circulation of human body and liver detoxification ability, reaches the effect that beautifies skin.

Clinical trial data:

1, because of visceral dysfunction, the pigmented lesions such as the chloasma faciei that causes, chloasma hepaticum adopt oral liquid of the present invention to follow the tracks for the treatment of.Because of visceral dysfunction, pigmented lesion 100 examples such as the chloasma faciei that causes, chloasma hepaticum, wherein, and male's 25 examples, women's 75 examples, in age 16-52 year, the patient is take person between twenty and fifty as main, take the women as many.

Clinical symptoms: face is partially dark, and facial long-term length has the pigmented lesions such as chloasma, chloasma hepaticum, and some is also with pox, skin sore, acne etc.The patient has dizziness, the Mental fatigue timidness due to deficiency of QI, and the tired lazy speech of limb, loss of appetite, the symptoms such as insomnia, most of patients have the constipation phenomenon.Wherein 15 routine patients have the alopecia phenomenon, have 4 routine patients alopecia areata to occur.The patient used the dermopathic medicine of existing multiple treatment more, DeGrain, or invalid.

Tcm diagnosis thinks, this disease is stagnant in internal organs, zang-fu disharmony, and qi depression to blood stasis has influence on the QI-blood circulation function of internal organs.Its inherent zang-fu disharmony is freely not to be fruit because, deficiency of both QI and blood, the stasis of blood stagnate, and depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation are answered in treatment.

Therapeutic Method: oral liquid of the present invention, Semen Ginkgo extrac has very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.Every day 3 times, each 6-10 gram, 10 days is a course for the treatment of, and common 1-3 course for the treatment of is effective, and pertinacious disease needs 4-5 the course for the treatment of, also can various dosage forms be used alternatingly.

Therapeutic effect: after 1-3 the course for the treatment of of taking medicine, the perusal facial colour spot from depth to shallow, eliminate the sixth of the twelve Earthly Branches gradually, the healing patient of clinical symptoms complete obiteration is 41 people, cure rate 41%; The perusal facial colour spot is obviously desalinated the sixth of the twelve Earthly Branches, but does not eliminate fully, and the produce effects patient that clinical symptoms disappears substantially is 45 examples, obvious effective rate 45%, and this part patient continues to take medicine; The perusal facial colour spot is slightly desalinated, patient's 10 examples that clinical symptoms has part to reduce, and effective percentage 10%, this part patient continues to take medicine; After 5 courses for the treatment of, symptom still unalterable patient is 4 examples, inefficiency 4%.After 3-4 the course for the treatment of, with patient's sx↓ of alopecia, begin to grow hair with the alopecia areata place of patients with alopecia areata.In following the tracks of the treatment patient, have no obvious adverse effect and toxic and side effects, after 9 courses for the treatment of, do not have to find to have the phenomenon of gastrointestinal upset.Follow up a case by regular visits to the healing patient and had no recurrence in 2 years.

2, because of menoxenia, the chloasma faciei that causes, the calm sexually transmitted disease (STD) of the full of stains or spots isochrome element of butterfly become

Adopt oral liquid of the present invention to follow the tracks of women patient's 100 examples for the treatment of, age 25-50 year, suffer from history 1-30, clinical symptoms: face is partially dark, facial long-term long have pigmented lesions such as chloasma, butterfly spot, with menoxenia, pass through smooth, piece, dysmenorrhea arranged through color is dark red.The patient has Deficiency and coldness of spleen and stomach, lustreless complexion and dark and gloomy, and face has the pigmented lesions such as chloasma, butterfly spot, and most of patients has the constipation phenomenon.The patient used the dermopathic medicine of existing multiple treatment more, DeGrain, or invalid.Tcm diagnosis thinks, this disease is stagnant in internal organs, zang-fu disharmony, and qi depression to blood stasis has influence on the QI-blood circulation function of internal organs.Its inherent zang-fu disharmony is freely not to be fruit because, deficiency of both QI and blood, the stasis of blood stagnate, and depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver dive bright, consumer product dredge stasis, loosening bowel to relieve constipation, promoting the circulation of QI to relieve pain are answered in treatment.The present invention has not only used Folium Ginkgo to remove free radical and antioxidation, add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body, improve blood circulation of human body and liver detoxification ability, reach the effect that beautifies skin.

Therapeutic Method: medicine is oral liquid of the present invention.Semen Ginkgo extrac is the concentrated granular shape, have very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.Each 6-10 gram, 10 days is a course for the treatment of, and common 1-3 course for the treatment of is effective, and pertinacious disease needs 4-5 the course for the treatment of, also can various dosage forms can be used alternatingly.

Therapeutic effect: after 1-3 the course for the treatment of of taking medicine, facial colour spot is eliminated from depth to shallow gradually, and the healing patient of clinical symptoms complete obiteration is 34 people, cure rate 34%; Facial colour spot is shallow by being deep to, and does not eliminate fully, and the produce effects patient that clinical symptoms disappears substantially is 41 examples, obvious effective rate 41%, and this part patient continues to take medicine; Facial colour spot slightly shoals, effective patient 12 examples that clinical symptoms has part to reduce, and effective percentage 12%, this part patient continues to take medicine; After 5 courses for the treatment of, symptom still unalterable patient is 13 examples, inefficiency 13%.In following the tracks for the treatment of healing patient, have no obvious adverse effect and toxic and side effects, after 9 courses for the treatment of, do not have to find to have the phenomenon of gastrointestinal upset.Follow up a case by regular visits to the healing patient and had no recurrence in 2 years.

Specific embodiment 1: the Qin, the woman, 28 years old, married, in October, 2009 was medical.Tell without face under the obvious inducement: existing brown spot, chloasma hepaticum 2 years, and deepen gradually to enlarge.The man and wife often bickers, and the own temper of readme is large, once repeatedly takes medicine, and in conjunction with the various QUBAN SHUANG of external, does not all obtain good therapeutic effect.When medical, the dark and gloomy taupe that is of meeting color, with two outsides, two cheeks for very, be dark-grey brown, pachylosis, superficial, without obvious subjective symptoms, lose heart, weak, waist soreness, indigestion and loss of appetite, two side of body distensions, increase the weight of menstrual period, light red tongue, and there is the tooth seal on the limit, white and thin fur, stringy and thready pulse, card belongs to the incoordination between the liver and spleen liver qi stagnation type.Give oral liquid treatment of the present invention, treat after 1 month, chloasma faciei, the chloasma hepaticum area obviously subtracts light, plaque area is dwindled, face before smooth exquisiteness, treat 3 months continuously after, skin of face is ruddy, is rich in gloss, readme temper begins gentle.The chloasma hepaticum complete obiteration.Chloasma slowly subtracts light.Follow up a case by regular visits to and had no recurrence in 3 years.

Specific embodiment 2: Qiu, 35 years old.Leave on the face cyasma after the fertility, readme is felt out of one's plate, and large stretch of chloasma hepaticum occurs, and is medical in June, 2010.Inquiry when medical: its menstrual cycle is normal, menstrual period 4～6d, on the low side through measuring, color is dim, the time folder stasis of blood piece, the fore udder distending pain of passing through, the time soreness of the waist and knees is arranged, sleeping difficult, two is just normal.Look into: the visible pregnant mottle of having one's face covered with, forehead, two cheeks and lip Zhou Juncheng patch.Cheek has chloasma hepaticum, and the colour of skin is pitch-dark.Pale tongue has petechia, white and thin fur, hesitant pulse.Dialectical genus: the network stasis of blood of suffering from a deficiency of the kidney hepatic depression and blood deficiency.With Ginkgo oral liquid of the present invention treatment, treat also had dissipation, menorrhagia by the swollen logical alleviation of fore udder, body of the tongue petechia in 1 month.Ruling by law is treated 2 months for another example: menstrual blood volume is recovered normal, the no longer distending pain of fore udder of passing through, and sleep also is improved.Look into: the patient face brown patch, chloasma hepaticum, cyasma dissipate substantially, and body of the tongue is light red, faint and stringy pulse.Following up a case by regular visits to did not have chloasma in 2 years again, and chloasma hepaticum is newborn, and the colour of skin begins to bleach, and is rich in gloss.

Claims

1. Folium Ginkgo oral liquid for beauty, it is characterized in that the parts by weight of various raw materials are in the described Folium Ginkgo oral liquid for beauty: 10～30 parts of Folium Ginkgos, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Poria, 10～20 parts in Flos persicae, 10～20 parts of Radix Curcumaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Flos Inulaes, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Flos Albiziaes, 10～20 parts of propolis, 10～20 parts of Caulis Spatholobis.

2. described Folium Ginkgo oral liquid for beauty according to claim 1, it is characterized in that the parts by weight of various raw materials are in the described Folium Ginkgo oral liquid for beauty: 10～30 parts of Folium Ginkgos, 10～15 parts of Herba Leonuris, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts in Poria, 10～15 parts in Flos persicae, 10～15 parts of Radix Curcumaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Flos Inulaes, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Flos Albiziaes, 10～20 parts of propolis, 10～20 parts of Caulis Spatholobis.

3. described Semen Ginkgo oral liquid for beauty according to claim 1, it is characterized in that the parts by weight of various raw materials are in the described Folium Ginkgo oral liquid for beauty: 10～30 parts of Folium Ginkgos, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Poria, 10～20 parts in Flos persicae, 10～20 parts of Radix Curcumaes, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Flos Inulaes, 10～15 parts of Flos Campsiss, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Flos Albiziaes, 10～15 parts of propolis, 10～15 parts of Caulis Spatholobis.

4. preparation method such as claim 1～3 Folium Ginkgo oral liquid for beauty as described in each is characterized in that the preparation method of described Folium Ginkgo oral liquid for beauty may further comprise the steps:

A. the Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into unguentum;

E. surplus stock is made unguentum;

F. adding dextrin after unguentum obtained above being mixed with the Folium Ginkgo extract unguentum of making is in harmonious proportion rear canned.

5. the preparation method of described Folium Ginkgo oral liquid for beauty according to claim 4, it is characterized in that: among the described step a, get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 8-12h, taking-up places cooling in the drying baker, pulverizes 80 mesh sieves with pulverizer, and powder places brown wide mouthed bottle to store.

6. described Folium Ginkgo beautifying oral liquid and preparation method thereof according to claim 4 is characterized in that: among the described step b, get and be made into 60% alcoholic solution; Then get ginkgo leaf powder and put into 60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 700mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.

7. the preparation method of described Folium Ginkgo oral liquid for beauty according to claim 4 is characterized in that: among the described step c, ginkgo biloba succi is used first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed; The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, after the sucking filtration end, gets filtrate and abandons filtering residue.

8. the preparation method of described Folium Ginkgo oral liquid for beauty according to claim 4 is characterized in that: in the described steps d, distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and be condensed into particulate matter or paste object.

9. the preparation method of described Folium Ginkgo oral liquid for beauty according to claim 4 is characterized in that: among the described step e, surplus stock is put into 10 times of amount ethanol, heating and refluxing extraction 2 times each 1～2 hour, merges 2 extracting solution and leaves standstill; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged, 1.36 o'clock filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, and extractum reduces pressure to get.

10. the preparation method of described Folium Ginkgo oral liquid for beauty according to claim 4 is characterized in that: among the described step f, with canned after making extractum and Folium Ginkgo extract that above-mentioned steps makes among the step e and fully mixing rear adding dextrin and be in harmonious proportion.