CN104473153A

CN104473153A - Beautifying mulberry oral liquid and preparation method thereof

Info

Publication number: CN104473153A
Application number: CN201410665603.3A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Guizhou evergreen Pharmaceutical Co., Ltd.
Priority date: 2014-11-20
Filing date: 2014-11-20
Publication date: 2015-04-01
Anticipated expiration: 2034-11-20
Also published as: CN104473153B

Abstract

The invention discloses a beautifying mulberry oral liquid. The beautifying mulberry oral liquid comprises the following active ingredients in parts by weight: 10-50 parts of mulberry, 10-20 parts of caulis spatholobi, 10-20 parts of perilla, 10-20 parts of radix angelicae sinensis, 10-20 parts of rhizoma bletillae, 10-20 parts of poria, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of fructus rubi, 10-20 parts of radix angelicae dahuricae, 10-20 parts of semen cuscutae, 10-20 parts of radix curcumae, 10-20 parts of radix astragali seu hedysari, 10-20 parts of myotonin, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of flos albiziae, 10-20 parts of herba leonuri, 10-20 parts of flos rosae rugosae, 10-20 parts of rhizoma drynariae, 10-20 parts of eclipta, 10-20 parts of Calendula officinalis, and 10-20 parts of elsholtzia ciliate. The mulberry has the effects of improving blood supply of skin (including scalp), nourishing skin and enabling the skin to be white and tender and blackening hairs, and the like, and can delay senescence. The beautifying mulberry oral liquid has the effects of replenishing blood and tonifying yin, engendering liquid and allaying thirst, lubricating the intestines and dispelling dryness, as well as beautifying and the like, as well as good healthy efficacies on wrinkled face, facial splash, dry stool, gloomy complexion and the like.

Description

Mulberries oral liquid of a kind of beautifying face and moistering lotion and preparation method thereof

Technical field

The present invention relates to the health products containing deriving from plant, animal or mineral component, particularly a kind of oral liquid and preparation method thereof of mulberries beauty treatment and eliminating spot.

Background technology

Beauty treatment is inseparable with beauty treatment.Only have the posteriori maintenance of emphasis just can have healthy perfectly skin.Could really reach radiant.But a lot of Ms only notes external beauty treatment and maintenance in life, but ignore inherent conditioning.

Current many beauty methods are that the holistic health of sacrificing people exchanges of short duration cosmetic result locally for, and this method can not keep the beautiful appearance of a people for a long time.Thus make people produce dependence to whatsit.These methods are also worth choosing.Beautifying face and moistering lotion the best way is careful in one's diet in daily life, rule of life, environmental factor.The auxiliary skin care products being equipped with beauty treatment class again.Easily reaching the object of beauty treatment unconsciously.Use various cosmetics nurse face and modify, can only deserve to be called elementary beauty treatment concept, and beauty treatment should be from inside conditioning, makes to have rosy cheeks gloss, skin is fine and smooth, the eyes are bright and piercing, thus reaches and beautify appearance, normal effect of protecting the youth.

The living and diet of modern people is too meticulous, and amount of exercise reduces, or eats and drinks immoderately, or overstrain, body metabolism function is failed gradually, causes visceral dysfunction, easily cause the pigmented lesion such as chloasma faciei, freckle.The traditional Chinese medical science is thought, facial colour spot is that the deficiency of blood is not dissolved in face because of zang-fu differentiation qi and blood disorder; Or because of inernal injuries caused by seven emotions, stagnation of QI due to depression of the liver, incoordination between the liver and the spleen; Or because of improper diet and overtiredness, irregular menstruation; Or because of the blood system of the strongly fragrant channels and collaterals of fire, ailment said due to cold or exposure is rich outward and caused by sending out.Adopt this kind of disease of western medicine, be mostly outer wiping or vitamins for oral administration, flavonols medicine.Because pathogenesis is more, adopt western medicine effect to differ, also not easily effect a radical cure, some medicine side effect is larger.

Chloasma, chloasma hepaticum are a kind of dyskinetic disease of skin of metabolism of pigment being common in face, and be apt to occur in female middle-aged, its cause of disease and pathogenesis are illustrated not yet completely.It is generally acknowledged morbidity and the endocrinopathy of chloasma, Ultraviolet radiation, inherent cause is relevant.But research is in recent years thought, the generation of chloasma, chloasma hepaticum also changes relevant with oxygen radical.Under normal physiological conditions, free radical constantly produces, but is also constantly eliminated, and makes it to be in a kind of dynamic equilibrium.And chloasma, chloasma hepaticum patient lipid peroxide (LPO) or Free Radical Level increases time, or antioxidase is as declines such as superoxide dismutase (SOD), catalase (CAT), glutathione (CSH) in body, the oxidation products such as lipid peroxide can not be removed in time, LPO is piled up in vivo.Thus accelerate the reaction of tyrosine series of oxidation.Blackening chromatophore produces melanin to be increased; Its product MDA (MDA) of LPO extremely unstable can cause protein molecule to occur to be cross-linked simultaneously, forms fluorescent chromophore-pigment.

Mulberries are the ripening fruits of Moraceae deciduous tree mulberry tree, and mulberries are again sorosis, mulberry jujube, and peasant likes the fresh fruit of its maturation to eat, and taste sweet juice is many, is one of fruit of often eating of people.Ripe mulberries matter is glossy, sour and sweet palatability, with individual large, meat is thick, look purplish red, the sufficient person of sugar is good.Gather during annual fruit maturation in 4 ~ June, clean, decontamination, dry or dry edible after summary steaming.

Before more than 2,000 years, mulberries have been the hired tonic of Chinese emperors.Because growing environment that mulberry tree is special makes sorosis have spontaneous growth, feature without any pollution, so mulberries are otherwise known as " holy fruit among the people ".Modern study confirms, containing the abundant composition such as activated protein, vitamin, amino acid, carrotene, mineral matter, resveratrol, anthocyanidin in mulberries fruit, nutrition is 5 ~ 6 times of apple, it is 4 times of grape, there is multiple efficacies, be described as " the best health fruit of 21st century " by medical circle.Often eat mulberries and can significantly improve body immunity, have and delay senility, effect of beautifying face and moistering lotion.

Traditional Chinese medicine thinks that mulberry fruit taste is sour, cold nature, have improve body immunity, enriching yin of enriching blood, promote the production of body fluid to quench thirst, the effect such as dry is dispelled in ease constipation, cure mainly deficiency of YIN-blood and cause have a dizzy spell, tinnitus palpitaition, irritated insomnia, soreness and weakness of waist and knees, poliosis, quench one's thirst only do, dry and hard excrement, nourishing yin and supplementing blood, improving eyesight are calmed the nerves, sharp joint, curing rheumatism, the effect such as to relieve the effect of alcohol.

Prevent vascular sclerosis: containing aliphatic acid in mulberry fruit, primarily of linoleic acid.Stearic acid and oleic acid composition, have and reduce fat, reduce blood fat, prevent the effects such as vascular sclerosis.

2, strengthening the spleen and stomach, aid digestion: containing nutriments such as tannic acid, aliphatic acid, malic acid in mulberry fruit, the digestion of fat, protein and starch can be helped, therefore the merit having strengthening the spleen and stomach aid digestion, can be used for treating the diarrhoea caused because of indigestion.

3, supplement the nutrients: the trace element etc. containing a large amount of moisture, carbohydrate, multivitamin, carrotene and needed by human in mulberry fruit, effectively can expand the blood volume of human body, and to mend and oiliness, be suitable for hypertension, gynaecological disease patient dietotherapy.

4, blacking hair and beauty: containing the nutriment that a large amount of needed by human body is wanted in mulberry fruit, also containing Wu Fasu, can make hair become black and glossy, can be used to beauty treatment.

Mulberry fruit, having another name called mulberry fruit, mulberry sugarcane, mulberry jujube, sorosis, black mulberry etc., is the fruit ear of moraceae plants mulberry.When mulberry fruit is tender, look blue or green, and taste acid, time aging, look purple is black, succulence, and taste is sweet.Ripe Mulberry fruit is nutritious, every 100 grams of mulberry fruit moisture contents 81.8 grams, 1.8 grams, protein, 0.3 gram, fat.Cellulose 4.9 grams, 10 grams, carbohydrate, ash content 1.2 grams, carrotene 30 microgram, thiamine 0.02 milligram, 0.06 milligram, riboflavin, vitamin E 6.95 milligrams, 33 milligrams, potassium, 0.27 milligram, zinc, copper 0.08 milligram, selenium 4.8 microgram.In addition, also containing tannic acid, malic acid, vitamin C and aliphatic acid etc.Its fat is mainly linoleic acid, oleic acid, palmitic acid, stearic acid and sad, n-nonanoic acid, capric acid, myristic acid, leukotrienes etc. on a small quantity.Traditional Chinese medicine thinks that mulberry fruit is tonified the liver and kidney, nourishing yin and nourishing blood, breath wind, have cure mainly palpitation and insomnia, have a dizzy spell, tinnitus, constipation night sweat, scrofula, the illness such as articular instability.

Mulberries are improved skin (comprising scalp) blood supply, nutrition skin, make the effects such as the delicate and Wu Fa of skin, and can delay senility.Mulberries are that the elderly is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food mulberry fruit can improving eyesight, the symptom that relieving eye strain is dry and astringent.Mulberries have immunologic enhancement.Mulberries have effect of gain to spleen, have humidification to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism.It can promote the growth of erythrocyte, prevents Neuroleptic Leukocytopenia, and has auxiliary effect to illnesss such as treatment diabetes, anaemia, hypertension, high fat of blood, coronary heart disease, neurasthenia.Mulberry fruit has promoting the production of body fluid to quench thirst, promotes digestion, helps the effects such as defecation, and proper amount of edible can promote gastric secretion, stimulates enterocinesia and removes scorching.Motherland's medical science is thought, mulberries are sweet in flavor and cold in property, there is liver-kidney tonifying, ease constipation of promoting the production of body fluid, the effect such as black invention order.

The various cosmetic health products sold on the market now, dragons and fishes jumbled together for medicine, and great majority are all businessman's amusement, without any effect, and can cause the huge injury of the person.Chinese medicine beauty treatment, fat-reducing, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.Present market in the urgent need to developing a kind of health products having reducing blood lipid, antibacterial, hypoglycemic, anti-oxidant, whitening spot-removing effect, and is developed mulberries class cosmetic health product and is just being met advantage that is nontoxic, that can be absorbed completely by organism, has huge market potential.

Summary of the invention

Technical problem to be solved by this invention is, the various cosmetic health products that market is sold, and dragons and fishes jumbled together for medicine, and great majority are all businessman's amusement, without any effect, and can cause the huge injury of the person; Traditional Chinese medicine thinks that mulberries tonify the liver and kidney, nourishing yin and nourishing blood, breath wind, have cure mainly palpitation and insomnia, have a dizzy spell, tinnitus, constipation night sweat, scrofula, the illness such as articular instability; Mulberries are improved skin (comprising scalp) blood supply, nutrition skin, make the effects such as the delicate and Wu Fa of skin, and can delay senility.Mulberries are that the elderly is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food mulberry fruit can improving eyesight, the symptom that relieving eye strain is dry and astringent.Mulberries have immunologic enhancement.Mulberries have effect of gain to spleen, have humidification to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Check melanin grows, and keeps skin gloss and elasticity to play no small effect.The present invention is the health products of green health environmental protection completely.Add that some are promoting blood circulation and removing blood stasis, the natural traditional Chinese medicine of inrigorating qi and promoting blood circulation, soothing liver-qi stagnation, calming the liver, enriching yin and nourishing kidney, clearing heat and detoxicating, clearing heat-fire, strengthening vital QI to eliminate pathogenic factors, logical internal organs lets out poison, promoting blood circulation to remove blood stasis, regulate the metabolic function of human body, improve blood circulation of human body and liver detoxification ability, reach the effect beautifying skin.

For solving above-mentioned technical barrier, the invention provides a kind of mulberries oral liquid of beautifying face and moistering lotion, in beautify oral liquid described in it, the parts by weight of various raw material can be: mulberries 10 ~ 50 parts, reticulate millettia 10 ~ 20 parts, purple perilla 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, bletilla 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, raspberry 10 ~ 20 parts, the root of Dahurain angelica 10 ~ 20 parts, the seed of Chinese dodder 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, motherwort 10 ~ 20 parts, rose 10 ~ 20 parts, the rhizome of davallia 10 ~ 20 parts, Eclipta prostrata 10 ~ 20 parts, pot marigold 10 ~ 20 parts, elscholtiza 10 ~ 20 parts.

The mulberries oral liquid of described beautifying face and moistering lotion, in beautify oral liquid described in it, the parts by weight of various raw material can also be: mulberries 10 ~ 30 parts, reticulate millettia 10 ~ 15 parts, purple perilla 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, bletilla 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, raspberry 10 ~ 15 parts, the root of Dahurain angelica 10 ~ 15 parts, the seed of Chinese dodder 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, motherwort 10 ~ 20 parts, rose 10 ~ 20 parts, the rhizome of davallia 10 ~ 20 parts, Eclipta prostrata 10 ~ 20 parts, pot marigold 10 ~ 20 parts, elscholtiza 10 ~ 20 parts.

The mulberries oral liquid of described beautifying face and moistering lotion, in beautify oral liquid described in it, the parts by weight of various raw material also can be: mulberries 10 ~ 40 parts, reticulate millettia 10 ~ 20 parts, purple perilla 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, bletilla 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, raspberry 10 ~ 20 parts, the root of Dahurain angelica 10 ~ 20 parts, the seed of Chinese dodder 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, the Radix Astragali 10 ~ 15 parts, heart of a lotus seed benevolence 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, motherwort 10 ~ 15 parts, rose 10 ~ 15 parts, the rhizome of davallia 10 ~ 15 parts, Eclipta prostrata 10 ~ 15 parts, pot marigold 10 ~ 15 parts, elscholtiza 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of mulberries oral liquid of beautifying face and moistering lotion, and described in it, the preparation process of beautifying face and moistering lotion mulberries oral liquid comprises following aspect:

A. the extraction of mulberries;

B. the extraction of other bulk drugs;

C. above-mentioned two kinds of extracts are merged concentrated; Sterilizing, adds honey seasoning and is prepared into oral liquid.

In described step a, can gather when annual fruit maturation in 4 ~ June, clean, decontamination, dry or omit after steaming and dry.

In described step a, comprise further, the mulberries dried can be put into ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; No. 2 extracts each 1 ~ 2 hour, are merged and leave standstill by the heating and refluxing extraction that added water by the mulberries dregs of a decoction that above-mentioned alcohol extract is crossed again 2 times; Merged by above-mentioned two kinds of extracts, decompression recycling ethanol, obtains mulberries extract.

In described step b, other raw materials can be cleaned impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add the water of other raw material gross weight 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of other raw material gross weight 7 times amount, decocts 1 ~ 1.5 hour, and get twice decocting liquid mixing, standing 1-2 as a child filtered to obtain extract afterwards.

In described step c, above-mentioned two kinds of extracts can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, for subsequent use.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of mulberries oral liquid of beautifying face and moistering lotion, and the preparation method of described oral liquid comprises further:

A, get all raw materials and put into ethanol and soak, heat is extracted 2 times, is component 1;

B, by the dregs of a decoction extracting in water 2 times of said extracted, be component 2;

C, by 2-in-1 and concentrated to component 1 and component; After adding dextrin mediation, sterilization is bottled.

In described step a, raw material can be added in the ethanol of all raw material weight 5-10 times amount and soak 1-2 hour, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts be merged and leaves standstill; In described step b, the dregs of a decoction of the raw material that can be crossed by above-mentioned alcohol extract again add water heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; In described step c, above-mentioned two kinds of extracts can be merged, when reduced pressure concentration relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, inserted in economic benefits and social benefits vacuum concentrator by above-mentioned two kinds of extracts, when being concentrated into 90 DEG C, relative density is the concentrate of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds the rear sterilization bottling of dextrin mediation.

The technique effect that the present invention is useful is, the present invention has advantage that is nontoxic, that can be absorbed completely by organism.Traditional Chinese medicine thinks that mulberry fruit is tonified the liver and kidney, nourishing yin and nourishing blood, breath wind, have cure mainly palpitation and insomnia, have a dizzy spell, tinnitus, constipation night sweat, scrofula, the illness such as articular instability; Mulberries are improved skin (comprising scalp) blood supply, nutrition skin, make the effects such as the delicate and Wu Fa of skin, and can delay senility.Mulberries are that the elderly is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food mulberry fruit can improving eyesight, the symptom that relieving eye strain is dry and astringent.Mulberries have immunologic enhancement.Mulberries have effect of gain to spleen, have humidification to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Check melanin grows, and keeps skin gloss and elasticity to play no small effect.The present invention is the health products of green health environmental protection completely.Add that some are promoting blood circulation and removing blood stasis, the natural traditional Chinese medicine of inrigorating qi and promoting blood circulation, soothing liver-qi stagnation, calming the liver, enriching yin and nourishing kidney, clearing heat and detoxicating, clearing heat-fire, strengthening vital QI to eliminate pathogenic factors, logical internal organs lets out poison, promoting blood circulation to remove blood stasis, regulate the metabolic function of human body, improve blood circulation of human body and liver detoxification ability, reach the effect beautifying skin.The present invention remains the beneficiating ingredient in mulberries greatly, makes it not have work in-process to run off, on the make avoids secondary pollution, is the cosmetic health product of green health environmental protection completely.

Detailed description of the invention

Everybody has a love of beauty, after especially our living condition is improved greatly, diligent especially to the pursuit of beauty.Current many beauty methods are that the holistic health of sacrificing people exchanges of short duration cosmetic result locally for, and this method can not keep the beautiful appearance of a people for a long time.Thus make people produce dependence to whatsit.These methods are also worth choosing.Beautifying face and moistering lotion the best way is careful in one's diet in daily life, rule of life, environmental factor.The auxiliary skin care products being equipped with beauty treatment class again.Easily reaching the object of beauty treatment unconsciously.Use various cosmetics nurse face and modify, can only deserve to be called elementary beauty treatment concept, and beauty treatment should be from inside conditioning, makes to have rosy cheeks gloss, skin is fine and smooth, the eyes are bright and piercing, thus reaches and beautify appearance, normal effect of protecting the youth.

Chinese medical discrimination thinks the facial colour spot such as chloasma, chloasma hepaticum or cause blood tired stagnant in face because of stagnation of liver qi, or causes because the deficiency of liver-yin and kidney-yin, flaring up of deficient fire pent-up are loose.Mulberries beauty treatment and eliminating spot oral liquid is to facial colour spots such as chloasma, chloasma hepaticum, butterfly macules according to motherland's medical science, complexion is simple and unadorned, defaecation and diagnosis and treatment and the pure traditional Chinese medicine oral liquid of one developed, in side mulberries have nourish blood, invigorate blood circulation, raw new, the filling liver kidney of paralysis of dispelling, beneficial smart bone merit; Eclipta prostrata, sealwort, elscholtiza are tonified the liver and kidney respectively, enrich blood invigorate blood circulation, the effect such as menstruction regulating and pain relieving, reticulate millettia removing heat from blood, clearind deficient heat, defaecation dredging collateral, fruit of glossy privet filling liver kidney, the network that stimulates the menstrual flow, ensuring proper downward flow of the blood, make heresy have outlet.Full policy is to the pathology of the deficiency of liver-yin and kidney-yin, stagnation of the circulation of vital energy blood addiction, and nourishing is harmonious with dredging, mends and without the fraud of the stagnant qi and blood of honey, is suitable for informal dress, and receives the merit that nti-freckle preserves youthful looks.

Chloasma, chloasma hepaticum are the diseases that long-term factors causes.The activity decrease of skin tyrosinase, melanocyte corpusculum quantity increases, and wherein oxygen radical is one of major reason of chloasma formation.The most important thing is the effect of antioxidase in body antioxidant system, wherein SOD is one of topmost enzyme.After this result of study display modeling, the MDA content of animal skin and hepatic tissue improves, and SOD content reduces, with normal group comparing difference highly significant (P < 0.01).After treatment, MDA content decreases, and SOD content increases, and compares with model group, significant difference (P < 0.05, P < 0.01); Wherein, heavy dose for the treatment of group and positive controls comparing difference are significantly (P < 0.05).Thus point out spot-removing beautifying face oral liquid of the present invention can scavenging activated oxygen and reduce free radical produce; Pathologic examination shows it can obviously improve histiocytic pathological change, alleviates epithelial hyperplasia, alleviates the expansion of skin corium thin vessels, reduces inflammatory cell number; SABC detection display its obviously can reduce melanin positive cell number and optical density in epithelial layer.Show that spot-removing beautifying face oral liquid has freckle removing and whitening effect.

Purple perilla: Classification system: Perilla frutescens.Perilla leaf taste warm in nature is pungent, have induce sweat, loose effect of trembling with fear, regulate the flow of vital energy and seeking.Be applicable to the illnesss such as cold, fever with aversion to cold, cough, asthma, fullness and oppression of chest and abdomen.Purple perilla, based on edible tender leaf, can be eaten raw or cook soup.Purple perilla is edible leaf not only, and its seed also because of the edible containing compositions such as high protein, oryzanol, vitamin E, vitamin B1, leukotrienes, linoleic acid, oleic acid, sterol, phosphatide, and has therapeutic action to coughing inverse, asthma due to excessive phlegm, the stagnation of the circulation of vital energy, constipation etc.Find after deliberation, the each position of purple perilla evenly has good antitumaous effect, especially stronger with the effect in blade, oleanolic acid is wherein a kind of very strong natural anti-cancer agent, there is the effect of pre-preventing tumor, there is again the effect of anti-inflammatory, calmness, cardiac stimulant, diuresis, develop immunitypty, reducing blood lipid and resistance growth of cancer cells.

The seed of Chinese dodder: Cuscuta chinensis is the seed of the dicotyledon scammonia section plant seed of Chinese dodder, Cuscuta australis, cuscuta japonica Choisy etc., has tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuity, consolidates effect of tire stopping leak.The seed of Chinese dodder be listed in Shennong's Herbal top grade return through: smell is pungent, sweet, flat nontoxic.Function with cure mainly: tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity.The waist knee muscles and bones being applicable to kidney deficiency and liver is ached, and legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination, urine have She's drop, dizzy, the disease such as blurring of vision, Hiccough and deaf and women is with down, habitual abortion.Generally be listed in top grade can taking for a long time to take improving eyesight for a long time and make light of one's life by commiting suicide and prolong life.

Rose: rose, the rose family, Rosa (Rosa rugosa Thunb.) rose is the flower of rosaceous plant rose and polyphyll rose.Rose sweet and slightly bitter taste, slightly warm in nature, return liver, spleen, stomach warp; Fragrance row is loose; There is liver soothing and depression relief, effect of regulating menstruation by adjusting the flow of blood; Cure mainly chest diaphragm full vexed, gastral cavilty, the side of body rib, swollen breasts, irregular menstruation, leukorrhea with reddish discharge, dysentery, traumatic injury, wandering arthritis, carbuncle swells.Profit gas, promoting circulation of blood, control wandering arthritis, loose tired pain relieving.Rose and complete stool have convergence, can be used for woman in menstrual period too much, and leukorrhea with reddish discharge and enteritis, diarrhea, the red half of intestines are hemorrhage.Regulate the flow of vital energy Xie Yu and blood falls apart the stasis of blood.Cure mainly stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, new wandering arthritis for a long time, spitting of blood of spitting blood, irregular menstruation, leukorrhea with reddish discharge, dysentery, acute mastitis, pyogenic infections." food book on Chinese herbal medicine " calls it, and " main sharp lung spleen, beneficial liver and gall, the fragrance of food is sweet and refreshing, makes us refreshing refreshing." long-term taking, cosmetic result is excellent, can scavenging free radicals effectively, eliminates pigmentation, makes us calling out and send out a youthful vigor." book on Chinese herbal medicine justice ": rose, fragrance is the denseest, turbid clearly and not, and and violent, soft liver is waken up stomach, and gas is invigorated blood circulation, and a surname is logical stops up stagnant and absolutely not pungent temperature is just dry fraud, and the disconnected gas that pushes away divides among medicine, has prompt effect and the most tractable person most, and fragrant all product, there is no equal.

The rhizome of davallia is bitter, temperature.Return kidney, Liver Channel.The strong bone of kidney tonifying, continues and hinders pain relieving.For lumbago due to the kidney deficiency, Hiccough and deaf, tooth mobility, falling winks frustrates, injured bone; Control alopecia areata outward, leucoderma.Kidney tonifying, invigorates blood circulation, hemostasis.Controlling suffers from a deficiency of the kidney rushes down and pain in the back for a long time, arthralgia due to wind-dampness, dentalgia, tinnitus, and falling flashes frustrates, bone fracture, appendicitis, alopecia areata, corn." property of medicine opinion ": " exhaustion or lesion of the five internal organs sextupole, mouth (one makes ' foot ') hand is not received, upper heat and lower cold for poison gas in main bone, wind blood pain." " Japan hanako materia medica ": " controls evil sore, loses rotten meat, desinsection." " Kaibao Bencao ": " main broken blood, hemostasis, benefit is traumaticd fracture.″

Eclipta prostrata has effect of convergence, hemostasis, filling liver kidney.Binomial nomenclature: Eclipta prostrata.For nourishing the medicine of convergence, there is the merit of astringing to arrest bleeding apocenosis, various haematemesis can be controlled, the diseases such as enterorrhagia.Smash juice painting eyebrow to send out, can promote hair growth, for oral administration have black, black effect.

Pot marigold, formal name used at school: Cymbopogon citrat.Pot marigold is rich in multivitamin, especially vitamin A and vitamin C; Almost each position can eat; Its petal has the function of beauty treatment, and flower is containing carotenoid, lycopene, violaxanthin, rubixanthin, volatile oil, resin, lymphatic temperament, malic acid etc.Root contains amaroid, mountain gold east glycol; Seed is containing glyceride, ceryl alcohol and alkaloid.Putting in shampoo to make hair color thin out.Pot marigold nature and flavor are light flat, and flower, leaf have anti-inflammatory, antibacterial action.The promoting flow of qi and blood circulation of root energy, flower can cool blood, hemostasis.The Europe outer various inflammation for skin, mucous membrane among the people, also can the various inflammation of orally taken for curing and ulcer.Fresh flowers can be placed in salad and eat.Pot marigold is rich in flavonoids active component, and this composition has anti-oxidant, antiangiogenic, anti-inflammatory, anti-allergy and antiviral effect, can be extracted and be applied to the high-end skin care item of anti-sensitive kinds by issofree technology to pot marigold active component.Superpower healing ability, sterilization convergence wound, administer inflammation, dark sore, pore is thick, prevents the generation of scar.Calm skin, improves sensitiveness skin quality.There is effect of maintenance scar.Moisten dry lip, promote the metabolism of skin.Especially for the skin of drying, the moisturizing effect of height is had.

Elscholtiza, another name perfume (or spice) is eaten, vanilla, Latin literary fame Elsholtzia ciliata (Thunb.) Hyland Chinese medicine name, and energy sweating relieving summer-heat, row water is loose wet, during warm stomach is adjusted.Cure mainly: the cold drink of Xia Yue sense is cold, and have a headache and fever, aversion to cold is lossless, and the feeling of stuffiness in chest is suffered from abdominal pain, vomiting and diarrhoea, oedema, beriberi.Sweating relieving summer-heat, row water is loose wet, during warm stomach is adjusted.Control the cold drink of Xia Yue sense cold, have a headache and fever, aversion to cold is lossless, and the feeling of stuffiness in chest is suffered from abdominal pain, vomiting and diarrhoea, oedema, beriberi." Japan hanako materia medica ": nontoxic, lower gas, except dysphoria with smothery sensation, treats inverse cold air of vomitting." Kaibao Bencao ": taste is pungent, tepor.Main abdominal pain due to acute vomiting and diarrhea is told down, and aproll swells.Its volatile oil of resisting pathogenic microbes effect has stronger inhibitory or killing effect to pathogenic microorganism. and experiment shows: Herba Moslae volatile oil infected by influenza has certain inactivation capacity, deactivation concentration 1: 1000 ~ 1: 2000; To staphylococcus aureus, beta streptococcus, typhoid bacillus, bacterium flexneri, corynebacterium diphtheriae, diplococcus meningitidis, micrococcus catarrhalis, all there is stronger antibacterial action, concentration 1: 4000 ~ 1: 25600.1: 2000 elsholtzia oil has akin sterilization capability with 75% alcohol when disposing of sewage miscellaneous bacteria, within 6 minutes, sterilization rate is respectively 99.2%, and 99.36%; The antibacterial intensity (staphylococcus aureus, micrococcus catarrhalis, bacterium flexneri) of elsholtzia oil higher than iodine liquid, but is weak than nitrofurazone and bromogeramine. elscholtiza decoction (1: 20) also has remarkable inhibitory action to Asia influenza A virus, capital section 68-1 Strain and orphan virus (ECH011) in vitro.

Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Heart of a lotus seed benevolence is conventional Chinese medicine. be again the food generally, often eaten, property slightly sweet flavor is slightly cold, and has inducing diuresis for removing edema, invigorating the spleen is dried, relaxing muscles and tendons removes the effect such as numbness, clearing away heat and eliminating pus, is conventional damp-clearing drug.Heart of a lotus seed benevolence is again a kind of beauty food, and normal food can keep human body skin gloss fine and smooth, eliminates acne, spot sparrow, senile plaque expelling, cyasma, butterfly macules, to furfur, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of the seed of Job's tears can be used as medicine again and cure the disease.Li Shizhen (1518-1593 A.D.) is recorded in Compendium of Material Medica: seed of Job's tears energy, and " invigorating spleen and reinforcing stomach, tonifying lung heat-clearing, removes wind prevailing over dampness.To cook a meal food, control cold air.Decoct drink, diuresis heat is drenched." in recent years, a large amount of scientific researches and clinical practice prove, the seed of Job's tears or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% to the inhibiting rate of cancer.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Root tuber of aromatic turmeric is pungent, bitter, cold.Return liver, the heart, lung channel.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice.For through closing dysmenorrhoea, chest and abdomen swelling and pain, shouting pain, pyreticosis coma, epilepsy is gone mad, and jaundice urine is red.Promoting qi circulation and removing obstruction in the collateral, cool blood breaks the stasis of blood.Control all pains of chest abdomen side of body rib, lose the heart demented, pyreticosis coma, spit blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood drenches, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman place vim and vigour pained, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main blood amasss, lower gas, myogenic, hemostasis, and broken extravesated blood, blood drenches, hematuria, metal-inflicted wound.

The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.But table is real evil to be contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst." herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood.”

Motherwort taste is arduous, cool.Invigorate blood circulation, silt of dispelling, menstruation regulating, disappear water.Treatment menoxenia, threatened abortion is had difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood at hematuria, and carbuncle swells sore.Motherwort containing the material such as leonurine, fumaric acid, has the effects such as promoting blood circulation for regulating menstruation, hypotensive, inducing diuresis to reduce edema.

Flos Albiziae contains silk tree glucoside, tannin, resolving stagnation for tranquilization, appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for confused and worried, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can five viscera settling, and will, happy color, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.Also have clearing away summerheat, face-beautifying and spot-removing such as to relieve the effect of alcohol at the effect." herbal warp " is said: " Flos Albiziae energy five viscera settling, and will, happy color." especially to pregnant woman, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.

Reticulate millettia property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, the deficiency of blood is sallow, paralysis and numbness, and arthralgia due to wind-dampness is activated blood and relaxed tendons; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb in every limb; Quadriplegia; Arthralgia due to wind-dampness; Women has through uncomfortable; Dysmenorrhoea.External application is the gynaecology's good medicine activated blood circulation and dispersed blood clots.

Bletilla is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatism and bleeding, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle swells, dislike sore, lose subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach "; Compendium of Material Medica: " smell (root) is bitter, flat, nontoxic.

Root of Dahurain angelica meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and clearing away cold, understand things pain-stopping, detumescence and apocenosis, eliminating dampness is band only." Japan hanako materia medica ": control the hot eyes triangular mass of mucous membrane growing from the inner corner of the eye, and tire patching leaks landing, broken place blood, mends new blood, acute mastitis, carbuncle on the back, scrofula, intestines wind, hemorrhoid complicated by anal fistula, apocenosis, desolation, mange, pain relieving myogenic, goes face Shao-defect scar.

Radix Angelicae Sinensis, its taste is sweet and weigh, therefore specially can enrich blood, and its gas is light and pungent, therefore again can promoting circulation of blood, and bowl spares has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Empty and the exterior syndrome being not relieved person of battalion, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can fall apart greatly Biao Weire, and show not hold back person, helps with rheum officinale and so on, can admittedly show again.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable

Raspberry is warm in nature; Sweet, sour; Return kidney, urinary bladder channel.Cure mainly: kidney-nourishing, controlling nocturnal emission with astringent drugs, contracting urine.For enuresis with renal asthenia, frequent urination, impotence and premature ejaculation, emission and spermatorrhea." Bencao Jingshu ": " raspberry, its main beneficial gas person, says beneficial vital essence also.Kidney storing essence, kidney receive gas, and vital essence is sufficient, then body is from light, send out white.Respectful main qi-restoratives of reviving is absolutely continuous, reinforcing yin essence Jianyang, smoothing skin, peace and internal organs.The main man's kidney-jing deficiency of Zhen Quan exhausts, impotence, woman's food have son.Large bright main five viscera settling, beneficial color, supports vital essence, long hair, Qiang Zhi.All get its kidney-nourishing and add essence, the adopted ear of sweet acid convergence." " property of medicine opinion " carry its: " main man's kidney-jing deficiency exhausts, woman's food have son.Main impotence.″

Specific embodiment 1:

Annual 4 ~ June gathers when mulberries fruit maturation, cleans, decontamination, dries or omits after steaming and dry.

Again the mulberries dried are added water or alcohol extract.

Again by all the other raw material reticulate millettias, purple perilla, Radix Angelicae Sinensis, bletilla, Poria cocos, the red sage root, raspberry, the root of Dahurain angelica, the seed of Chinese dodder, root tuber of aromatic turmeric, the Radix Astragali, heart of a lotus seed benevolence, the bighead atractylodes rhizome, Flos Albiziae, motherwort, rose, the rhizome of davallia, Eclipta prostrata, pot marigold, elscholtiza adds water or ethanol is condensed into extract.

The extract of mixing mulberries extract and other raw materials, adds appropriate dextrin or honey and is in harmonious proportion then ultraviolet radiation for sterilizing and disinfecting and bottles, directly drink during use.

Specific embodiment 2:

Annual 4 ~ June gathers when mulberries fruit maturation, cleans, decontamination, dries or omits after steaming and dry, about 5000g; The mulberries dried are put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; Again the mulberries dregs of a decoction that above-mentioned alcohol extract is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; Merged by above-mentioned two kinds of extracts, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, and by gained concentrate adjustment proportion to 1.06, decompression recycling ethanol, obtains mulberries extract; By surplus stock reticulate millettia 1500g, purple perilla 1500g, Radix Angelicae Sinensis 1500g, bletilla 1500g, Poria cocos 1500g, red sage root 1500g, raspberry 1500g, root of Dahurain angelica 1500g, seed of Chinese dodder 1500g, root tuber of aromatic turmeric 1500g, Radix Astragali 1500g, heart of a lotus seed benevolence 1500g, bighead atractylodes rhizome 1500g, Flos Albiziae 1500g, motherwort 1500g, rose 1500g, rhizome of davallia 1500g, Eclipta prostrata 1500g, pot marigold 1500g, elscholtiza 1500g cleans impurity elimination, dry, be ground into particle, soak 1 hour; Soaked bulk drug is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medicinal material 7 times amount, decocts 1 ~ 1.5 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and make granule.Mixed with other raw material extracts made by mulberries extract, add honey and be in harmonious proportion, ultraviolet disinfection, packs and get final product again.

Specific embodiment 3:

Annual 4 ~ June gathers when mulberries fruit maturation, clean, decontamination, dry or omit after steaming and dry, about 3500g, again by surplus stock reticulate millettia 1000g, purple perilla 1000g, Radix Angelicae Sinensis 1000g, bletilla 1000g, Poria cocos 1000g, red sage root 1000g, raspberry 1000g, root of Dahurain angelica 1000g, seed of Chinese dodder 1000g, root tuber of aromatic turmeric 1000g, Radix Astragali 1000g, heart of a lotus seed benevolence 1000g, bighead atractylodes rhizome 1000g, Flos Albiziae 1000g, motherwort 1000g, rose 1000g, rhizome of davallia 1000g, Eclipta prostrata 1000g, pot marigold 1000g, elscholtiza 1000g cleans impurity elimination, all raw materials are put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill, again the raw material dregs of a decoction that above-mentioned alcohol extract is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill, merged by above-mentioned two kinds of extracts, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, by gained concentrate adjustment proportion to 1.06, merges twice decocting liquid, filters to get filtrate, the filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours, refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and make granule.Mixed with other raw material extracts made by mulberries extract, add dextrin and be in harmonious proportion, ultraviolet disinfection, packs and get final product again.

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: oral liquid for beauty of the present invention (by implementation method preparation).

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve suppository, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Suppository adding distil water is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Test example 2: acute skin irritation test report of the present invention

1, experiment purpose: detect the present invention to the stimulation/corrosiveness of animal used as test skin and intensity

2, materials and methods:

2.1. tested material: beautifying liquid of the present invention (obtaining by embodiment method)

2.2. animal used as test: one grade of large ear white race rabbit, 10, female, body weight 2.1-2.3kg; Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;

2.3. test method:

Its backbone both sides, back are cut by hair in test by the healthy rabbits selecting skin intact 10 for first 24 hours, the left and right each about 4cm × 4cm of unhairing area.Get tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Close after 4 hours, dismantle, and go residual tested material with warm water cleaning, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and mark.

3, experimental result: any erythema does not appear in animal used as test skin, red and swollen, inflammation phenomenon.

4, brief summary: judge according to skin wound repair standards of grading in " disinfection technology standard " (1999), the present invention belongs to nonirritant to animal skin stimulus intensity.

Embodiment 3: long term toxicity test data

1, experimental technique

Random for cavy part is become 4 groups, often organizes 15.In guinea pig back backbone both sides, hair remover is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean hair remover, observe and often organize cavy after 24 hours and be coated with oral liquid solution 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of cavy, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication cavy trunk unhairing districts, having no local skin has oedema, hyperemia, erythema, blutpunkte and ulcer.Medication group and control animals chroma of hair, ingest, the control group no significant difference such as four limbs are movable, blood biochemistry checking, medication group and control group are all in normal range (NR).Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathology.Prompting, traditional Chinese medicine oral liquid long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.

Result of the test shows: oral liquid for beauty experiment safety of the present invention.This medicine is 1: 150 to beta streptococcus, staphylococcus aureus, colibacillary MIC, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.

Pharmacological experiment:

1 material

1.1 animals: healthy 3 monthly age pure lines Kunming kind female mice 60, body weight 25 ~ 35g, the animal used as test department of the Chinese Academy of Sciences of University Of Qingdao provides.Animal feeding condition: often organize mouse by group sub-cage rearing.When natural conditions are identical, routine raises food drinking-water, keeps natural lighting, without undesirable element impact, raises after within 1 week, adapting to experimental situation and starts to test,

1.2 experimental drugs: spot-removing beautifying face oral liquid: by mulberries, reticulate millettia, purple perilla, Radix Angelicae Sinensis, bletilla, Poria cocos, the red sage root, raspberry, the root of Dahurain angelica, the seed of Chinese dodder, root tuber of aromatic turmeric, the Radix Astragali, heart of a lotus seed benevolence, the bighead atractylodes rhizome, Flos Albiziae, motherwort, rose, the rhizome of davallia, Eclipta prostrata, pot marigold, elscholtiza, adds water or alcohol extract.Pharmacy of the court produces.3% Hydrochinone Cream: Pharmacy of Shanghai Long March Hospital produces.Progesterone injection: Zhejiang Province XianJu Pharmacy stock Co., Ltd, lot number: 20050115.

1.3 reagent: vulcanized sodium (NaS): the limited public affairs of extra large Ling Feng chemical reagent can, lot number: 20020118, is made into 10% aqueous solution before use.Superoxide dismutase (SOD), MDA (MDA) kit: Bioengineering Research Institute is built up in Nanjing, lot number: 20059116.

1.4 key instruments: DY89-II type electric driven glass refiner: Xin Lan biotech inc, Ningbo.System biological microscope: OLYMPUS; BX50F4 Beijing Institute of Aeronautics Pathologic image analysis system.

2 experimental techniques

2.1 modellings: with reference to chloasma experimental animal model clone method.After the anesthesia of mouse 2.5% yellow Jackets, the progesterone injection with 0.4% presses the intramuscular injection of 0.02g/kg dosage mouse hind leg, 6 times weekly, continuous 4 weeks.Normal group presses 0.02g/kg intramuscular injection sterilized water for injection.

2.2 animal grouping and administrations: get Healthy female mouse 60,3 dosage groups, are divided into 6 groups at random, often organize 10.Normal group, model group, spot-removing beautifying face oral liquid of the present invention 3 dosage groups (0.15,0.3,0.6g/g), 3% quinhydrones positive controls (0.6g/g).Spot-removing beautifying face oral liquid of the present invention 3 dosage treatment groups respectively in mouse modeling medication on the same day, every day 1 time, 6 times weekly, continuous use 30 days.Normal group and model group give distilled water in the corresponding time; 3% quinhydrones positive drug control group started local application in modeling the same day, and time and the course for the treatment of are with spot-removing beautifying face oral liquid treatment group.

2.3 observation index and detection: medication is after 30 days, and cervical dislocation puts to death mouse, back unhairing, get rapidly each 2 pieces of the skin histology at hepatic tissue and coating position, wherein one piece with ice-cold normal saline flushing, removing blood, and filter paper blots, cut liver and each 0.5g of skin, put into the beaker of the pre-cold saline of 2.0ml respectively, shred tissue, then pour in test tube, with high speed disperser 10r/m in homogenate twice, each 10 seconds; With 3500r/min rotating speed centrifugal 15 minutes again, get supernatant.Adopt xanthine oxidase, detect description method by kit and measure SOD; Adopt thiobarbituricacidα-method, detect description method by kit and measure MDA value.Meanwhile, separating mouse skin of back, get plucked skin histology one piece (about 2cm*1cm), 10% paraformaldehyde is fixed, routine paraffin wax embeds, section, and HE dyes, routine histopathologic detects, om observation, counting epithelial proliferation, dermal vascular number and chorionitis cell number; Immunohistochemical staining, (positive cell: nothing, counts 0 point for the dyeing of observation melanocyte and number; < 15%, counts 0.5 point, < 30%, counts 1 point; > 30% 2 points).

2.4 statistical methods: compare t inspection between measurement data employing group; Layered method data adopts rank test to carry out statistical disposition.

3 results

3.1 respectively organize mouse skin, hepatic tissue MDA, SOD content mensuration in table 1.

The mensuration (-x ± s) of mouse skin and hepatic tissue MDA, SOD content respectively organized by table 1

* P < 0.05, * * P < 0.01 is compared with model group; #**P < 0.05 is compared with positive group

3.2 respectively group mouse skin Pathomorphologics and immunohistochemistry views PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM visible: the epithelial layer cell arrangement of normal group mouse skin is neat, and without hyperplasia, have no thin vessels in skin corium and expand, inflammatory cell is rare.The epithelial layer hyperplasia of model group mouse skin is obvious, and the large and arrangement disorder of core, visible thin vessels expansion in skin corium, inflammatory cell is common.The epithelial layer hyperplasia of dosage group big or middle and positive controls mouse skin alleviates to some extent, and arrangement disorder alleviates, and in skin corium, thin vessels expansion alleviates, and inflammatory cell is rare.The results are shown in Table 2.

Immunohistochemical PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM is visible: visible a little melanocyte in normal group mouse epithelial layer, the painted sepia of endochylema.Visible a large amount of melanocyte in model group mouse epithelial layer, the painted dark brown of endochylema, and positive cell number > 30%.Visible black color element cell in dosage group big or middle and positive controls mouse epithelial layer, the painted dark brown of endochylema, positive cell number reduces, in table 2.

Table 2 is group mice skin tissue Pathomorphology and melanocyte observed result (n) respectively

Rank test; * P < 0.05, * * P < 0.01 is compared with model group

4 discuss

The chloasma traditional Chinese medical science is called " chloasma hepaticum ", belongs to motherland's medical science " dark spot " or " dusty complexion " category.It is generally acknowledged that this disease occurs with liver,spleen,kidney three dirty in close relations.

Theory of traditional Chinese medical science is thought " lung governing skin and hair ", as " Plain Questions " six saves state of internal organs opinion cloud: also, its Hua Mao, it fills at skin, points out that lung closes fur at body for lung person, the dominator of QI, the position of storing soul.When the function of lung is normal, lung yin fills, and normal lung-QI is peaceful, and body fluid is sufficient, and ability compress must be capable, and skin metabolism product is excreted, and makes skin clean, naturally shines gloss.Therefore have many doctors from ancient times to the present, recipe has and controls from lung opinion, we think that relevant, that people is corresponding to the world theory of traditional Chinese medicine look effect is one of characteristic of traditional Chinese therapeutics, and lung governing skin and hair is corresponding with white, the rule of this our prescription just.

Face-beautifying oral liquid of the present invention, the traditional Chinese medical science thinks that mulberry fruit is tonified the liver and kidney, nourishing yin and nourishing blood, breath wind, have cure mainly palpitation and insomnia, have a dizzy spell, tinnitus, constipation night sweat, scrofula, the illness such as articular instability; Mulberries are improved skin (comprising scalp) blood supply, nutrition skin, make the effects such as the delicate and Wu Fa of skin, and can delay senility.Mulberries are that the elderly is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food mulberry fruit can improving eyesight, the symptom that relieving eye strain is dry and astringent.Mulberries have immunologic enhancement.Mulberries have effect of gain to spleen, have humidification to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Check melanin grows, and keeps skin gloss and elasticity to play no small effect.The bighead atractylodes rhizome, enters taste warp, has air making-up and spleen enlivening, eliminating dampness Li Shui, beauty treatment benefit flesh, effect of promoting longevity.Modern pharmacology research shows: the bighead atractylodes rhizome, and containing volatile oil 1.4%, principal component is atractylol (alcohol radical hydrolysis generates lipid), atractylone, and containing vitamin A.The root of Dahurain angelica, have promoting the circulation of qi fall apart blood, dispel rheumatism, effect of swelling and pain relieving, skin moistening and itch stopping.Shennong's Herbal carries: " longue skin, moist color, can make face fat ".Song's " large China's tomorrow all book on Chinese herbal medicine " is carried: " remove the black dry flaw in face, broken place blood, mends new blood ".Modern pharmacology research shows that the root of Dahurain angelica contains yellow volatile oil 0.24%; Byak-angelicin, Byakangelicol (containing multiple hydroxyl constituents).The root of Dahurain angelica activates in high concentration, low concentration has inhibitory action.The Radix Astragali have relieving cough and asthma, relax bowel, happy damp appearance, except the black dry merit brightening, dispelling wind and arresting itching.As " Jing Yue's complete work. book on Chinese herbal medicine just under " carry: " especially kill parasites, tooth worm and the black dry Epileptic of women's head-ornaments look into suitcase ".Full side is made up of mulberries, the bighead atractylodes rhizome, the root of Dahurain angelica, reticulate millettia, Eclipta prostrata etc., has the effect of profit skin, de-black pigment, happy look of preserving youthful looks.

Specific embodiment: Lee, female 33 years old, white collar, married, educate a son, readme Work Home life stress is large, facial large area chloasma hepaticum, chloasma, and did laser, the various beauty treatment of skin is changed in beauty treatment, effect is undesirable, and color spot easily rebounds.Face is dark and gloomy simple and unadorned, and tongue fur is scarlet, irritability, likes sulky.Readme irregular menstruation, dysmenorrhoea.Occasionally there is clot.Evening, sleep was bad, liked to have horrible nightmares.Trick is ice-cold, and frequent eye dry eyes are puckery.Come beauty treatment section of the court to go to a doctor, attempt taking oral liquid for beauty of the present invention.Mulberry fruit is tonified the liver and kidney, nourishing yin and nourishing blood, breath wind, have cure mainly palpitation and insomnia, have a dizzy spell, tinnitus, constipation night sweat, scrofula, the illness such as articular instability; Mulberries are improved skin (comprising scalp) blood supply, nutrition skin, make the effects such as the delicate and Wu Fa of skin, and can delay senility.Mulberries are that the elderly is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food mulberry fruit can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fang Yong: mulberries 30g, reticulate millettia 12g, purple perilla 12g, Radix Angelicae Sinensis 11g, bletilla 13g, Poria cocos 12g, red sage root 13g, raspberry 13g, root of Dahurain angelica 12g, seed of Chinese dodder 13g, root tuber of aromatic turmeric 12g, Radix Astragali 13g, heart of a lotus seed benevolence 12g, bighead atractylodes rhizome 13g, Flos Albiziae 14g, motherwort 13g, rose 12g, rhizome of davallia 13g, Eclipta prostrata 13g, pot marigold 14g, elscholtiza 14g.Every day three.Use two weeks, readme sleep quality improves, and the dim phenomenon of skin takes a turn for the better.Re-use one month, irregular menstruation, dysmenorrhoea is improved.Facial colour spot starts to disappear, and the colour of skin is ruddy.The puckery phenomenon of eye dry eyes is improved, and temper is irritability no longer, and take more exercises emotion regulation.Then use one month, chloasma hepaticum disappears.

Claims

1. the mulberries oral liquid of a beautifying face and moistering lotion, it is characterized in that, in described beautify oral liquid, the parts by weight of various raw material comprise: mulberries 10 ~ 50 parts, reticulate millettia 10 ~ 20 parts, purple perilla 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, bletilla 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, raspberry 10 ~ 20 parts, the root of Dahurain angelica 10 ~ 20 parts, the seed of Chinese dodder 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, motherwort 10 ~ 20 parts, rose 10 ~ 20 parts, the rhizome of davallia 10 ~ 20 parts, Eclipta prostrata 10 ~ 20 parts, pot marigold 10 ~ 20 parts, elscholtiza 10 ~ 20 parts.

2. the mulberries oral liquid of beautifying face and moistering lotion according to claim 1, it is characterized in that, in described beautify oral liquid, the parts by weight of various raw material comprise: mulberries 10 ~ 30 parts, reticulate millettia 10 ~ 15 parts, purple perilla 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, bletilla 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, raspberry 10 ~ 15 parts, the root of Dahurain angelica 10 ~ 15 parts, the seed of Chinese dodder 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, motherwort 10 ~ 20 parts, rose 10 ~ 20 parts, the rhizome of davallia 10 ~ 20 parts, Eclipta prostrata 10 ~ 20 parts, pot marigold 10 ~ 20 parts, elscholtiza 10 ~ 20 parts.

3. the mulberries oral liquid of beautifying face and moistering lotion according to claim 1, it is characterized in that, in described beautify oral liquid, the parts by weight of various raw material comprise: mulberries 10 ~ 40 parts, reticulate millettia 10 ~ 20 parts, purple perilla 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, bletilla 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, raspberry 10 ~ 20 parts, the root of Dahurain angelica 10 ~ 20 parts, the seed of Chinese dodder 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, the Radix Astragali 10 ~ 15 parts, heart of a lotus seed benevolence 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, motherwort 10 ~ 15 parts, rose 10 ~ 15 parts, the rhizome of davallia 10 ~ 15 parts, Eclipta prostrata 10 ~ 15 parts, pot marigold 10 ~ 15 parts, elscholtiza 10 ~ 15 parts.

4. the preparation method of the mulberries oral liquid of beautifying face and moistering lotion as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of the mulberries oral liquid of described beautifying face and moistering lotion comprises following aspect:

A. the extraction of mulberries;

B. the extraction of other bulk drugs;

5. the preparation method of beautifying face and moistering lotion mulberries oral liquid according to claim 4, is characterized in that, in described step a, gather during annual fruit maturation in 4 ~ June, cleans, decontamination, dries or dries after slightly steaming.

6. the preparation method of the mulberries oral liquid of beautifying face and moistering lotion according to claim 4, is characterized in that, in described step a, comprise further and the mulberries dried are put into ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, is merged by No. 2 extracts and leaves standstill; No. 2 extracts each 1 ~ 2 hour, are merged and leave standstill by the heating and refluxing extraction that added water by the mulberries dregs of a decoction that above-mentioned alcohol extract is crossed again 2 times; Merged by above-mentioned two kinds of extracts, decompression recycling ethanol, obtains mulberries extract.

7. the preparation method of the mulberries oral liquid of beautifying face and moistering lotion according to claim 4, is characterized in that, in described step b, other raw materials are cleaned impurity elimination, dries, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add the water of other raw material gross weight 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of other raw material gross weight 7 times amount, decocts 1 ~ 1.5 hour, and get twice decocting liquid mixing, standing 1-2 as a child filtered to obtain extract afterwards.

8. the preparation method of the mulberries oral liquid of beautifying face and moistering lotion according to claim 4, it is characterized in that, in described step c, above-mentioned two kinds of extracts are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, for subsequent use.

9. a preparation method for basis mulberries oral liquid of beautifying face and moistering lotion as described in any one of claims 1 to 3 item, it is characterized in that, the preparation method of described oral liquid comprises further:

10. the preparation method of the mulberries oral liquid of beautifying face and moistering lotion according to claim 9, it is characterized in that: in described step a, raw material is added in the ethanol of all raw material weight 5-10 times amount and soak 1-2 hour, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; In described step b, then the dregs of a decoction of the raw material crossed by above-mentioned alcohol extract add water heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; In described step c, above-mentioned two kinds of extracts are merged, when reduced pressure concentration relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, inserted in economic benefits and social benefits vacuum concentrator by above-mentioned two kinds of extracts, when being concentrated into 90 DEG C, relative density is the concentrate of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds the rear sterilization bottling of dextrin mediation.