CN108096439A

CN108096439A - A kind of trollflower health care oral liquid for beauty treatment of invigorating blood circulation and preparation method thereof

Info

Publication number: CN108096439A
Application number: CN201711431557.0A
Authority: CN
Inventors: 谢小坚
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-12-22
Filing date: 2017-12-22
Publication date: 2018-06-01

Abstract

The present invention discloses a kind of trollflower health care oral liquid for beauty treatment of invigorating blood circulation, and includes the bulk pharmaceutical chemicals of following parts by weight：10~50 parts of trollflower, 10~20 parts of mulberries, 10~20 parts of Caulis Spatholobi, 10~20 parts of mulberry leaf, 10~20 parts of gynostemma pentaphylla, 10~20 parts of Radix Paeoniae Alba, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of motherwort, 10~20 parts of lucid asparagus, 10~20 parts of lotus seeds, 10~20 parts of wrinkled giant hyssop, 10~20 parts of cape jasmine, 10~20 parts of purple perilla, 10~20 parts of matrimony vine, 10~20 parts of Flos Albiziae, 10~20 parts of Asian puccoon, 10~20 parts of Rhizoma Atractylodis Macrocephalae, 10~20 parts of Radix Rehmanniae, 10~20 parts of korean pine seed, 10~20 parts of stringy stonecrop.Promoting blood circulation and removing obstruction in channels, enriching yin moisturizing of the invention, tonifies the liver and kidney, the regulation of qi and blood is cured the disease and taken into account with beauty treatment.Women takes individuation oral liquid, and by Heibei provincial opera of the present invention, planning slowly and carefully, long-acting help human liver kidney qi blood, promoting blood circulation and removing blood stasis, nourishing Yin and moistening lung can improve facial blood circulation, adjust the endocrine function gradually to fail, the aging of delaying female, the beautiful skin of beauty treatment.

Description

A kind of trollflower health care oral liquid for beauty treatment of invigorating blood circulation and preparation method thereof

Technical field

The present invention relates to the health products containing the promoting blood circulation beauty treatment from plant composition, more particularly to a kind of beauty treatment of invigorating blood circulation Trollflower health care oral liquid and preparation method thereof.

Background technology

Beauty is inseparable with beauty treatment.The perfect skin of health can just be possessed by only focusing on posteriori maintenance.Ability It is really achieved radiant.However, many Mies only pay attention to external beauty and maintenance in life, inherent tune is but ignored Reason.

Women physique characteristic and damage capacitive disease correlation women have through, band, tire, production physilogical characteristics, women's is inclined There is gas, blood, the inclined of yin, yang and contains or decline partially in quite constitution, will result in many damage capacitive diseases based on yin and yang qi and blood disorder Disease.《Plain Questions ancient times innocent opinion》In several stages of the original text than more fully describing woman's all one's life, where it is proposed woman one Aging in life is since five or seven, and such as " five or seven yangming meridians decline, the face becoming withered, and hair begins to fall；673 Yang Mai decline in upper, and face is all Coke, hair begin white." visible passages through which vital energy circulates yang blood and qi it is unbalance cause appearance, skin, hair even reproductive function progressively fail.Modern times grind Study carefully and show that internal organs, qi and blood functional disturbance are the basic reasons for generating chloasma faciei.So understand the somatotypes of women, and Set about coming maintaining healthy and beauty from constitution adjusting yang blood and qi balance is improved, be the frontier of current " preventiveing treatment of disease " theory, Highlight the characteristic and advantage of constitution theory in traditional Chinese medicine health.

" have Zhu Neibi shapes all outer " is thought in traditional Chinese medical science entirety beauty treatment sight, and people is an organic whole, and face face are whole A part for body, local is beautiful, and dependent on whole equilibrium between yin and yang, internal organs are stabilized, channels and collaterals are unobstructed, qi and blood circulation.It gets rid of illness foster Face class prescription is according to the principle of the traditional Chinese medical science " searching for the primary cause of disease in treatment ", and disappear color spot on the basis for the treatment of gynaecology protopathy, cures the disease and beauty treatment It develops simultaneously.

The living and diet of modern people is excessively fine, and amount of exercise is reduced or eaten and drunk immoderately or overstrain so that human body Metabolism gradually fails, and causes visceral dysfunction, easily causes the pigmented lesions such as chloasma faciei, freckle.In Doctor thinks that facial colour spot is because of zang-fu differentiation qi and blood disorder, and the deficiency of blood is not dissolved in face；Or because of inernal injuries caused by seven emotions, stagnation of QI due to depression of the liver, liver and spleen is not With；Or because of improper diet and overtiredness, irregular menstruation；Or the blood system because of the strongly fragrant channels and collaterals of fire, it is rich outside ailment said due to cold or exposure and caused by sending out.It is this kind of using western medicine Disease is mostly outer wiping or vitamins for oral administration, flavonols drug.Since pathogenesis is more, using western medicine treatment effect not One, it is not easy to effect a radical cure, some medicine side effects are larger.

Trollflower is also referred to as nasturtium, golden lotus etc., belongs to the flower of Ranunculaceae spider, is generally grown in mountainous region grass In slope, there is the plantation of official in the Hebei in China, Shanxi and Inner Mongol ancient capital.Trollflower is bloomed in annual summer, picks it After dry, it is necessary to when take out use.Under normal circumstances, if drying, without the golden yellow lily feet of impurity and color Flower, that is, belong to superior.

Think lily feet bitter cold in nature in terms of the traditional Chinese medical science, there is clearing heat and detoxicating and reducing pharyngeal swelling after taking, especially It is suitble to some tonsillotome inflammation, upper sense, sphagitis, otitis media acuta, aphtha, acute conjunctivitis and acute lymphangitis and urgency The patient of property periostitis takes, all well and good to the health-care effect of body.

Trollflower whole body is all precious, have after being taken except flower to body all well and good health care and health effect it Outside, the leaf of this plant is also that can be used as medicine, and plays an important role of to nourish the liver to improve visual acuity, and is suitble to some stomatitis, pharyngitis and urgency The patient of property angioleucitis takes, and effect is very good.Specific trollflower soaked the effect of drinking, is as follows：

First：It dispels fiery heat-clearing, the trollflower that we at most touch in life is all the petal after drying process in fact, This Chinese medicine have effects that it is very good reduce internal heat, also with certain drop heat effect.Trollflower is suitble to take in summer, Hot season, which brews this medicinal material, takes, and plays an important role of fiery heat-clearing of dispelling.Trollflower is also used as a kind of dish and uses, Cold and dressed with sauce trollflower is a kind of special dish, can not only solve the problems, such as excessive internal heat and nourishing, while taste is also unusual Well, small compile suggests that excessive internal heat patient must not miss this road recipe.

Second：Scytitis is treated, many people are ignorant to be, trollflower has very good antiphlogistic effects.This is Because containing abundant vitamin C and minerals in trollflower, in these substances enter after body and can effectively alleviate Portion's inflammation, especially for the inflammation treatment best results on some skins.If saying, there is inflammation in the skin of body, then can It is not only easy to operate while self-recovery health can also be effectively promoted to take trollflower is soaked.

3rd：Improve constipation, trollflower soaked the effect of drinking, further includes improvement constipation, this be a kind of trollflower very it is good simultaneously And the effect that effect is big.Trollius can effectively treat some enteron aisles afterwards in a kind of Chinese medicine cold in nature into body Scorching defect finally plays cleaning enteron aisle and the effect away from constipation.Everybody is suggested otherwise, contained fat in trollflower Fat amount is not high, is used so this medicinal material can also be used as with a kind of slimming drugs, but will in accordance with the method for science.

4th：It invigorates blood circulation beauty treatment, makes containing substantial amounts of carrotene and trace element, vitamin etc., science in trollflower With the required nutriment of soma can be supplemented.If can science and health use trollflower, can play It promoting blood circulation beauty treatment and refreshes the mind and other effects, benefit is very good.

Scientist is had found by modern technologies, is made in trollflower containing substantial amounts of alkaloid, Flavonoid substances, science Inflammation-diminishing and cough-controlling, pharynx-clearing throat-benefiting and clearing heat and detoxicating and promoting blood circulation beauty treatment effect can be played with this Chinese medicine.If in life There is tonsillitis, fatigue, larynx fire and chronic pharyngitis etc., can be treated by taking trollflower.

Trollflower can use at all seasons, act not only as a kind of tea-drinking of the daily life of a family, while can also entertain guests at a banquet And give a present, it is widely used.Lung capacity can effectively be enhanced by often taking trollflower, and oxygen uptake capacity can also enhance, not only may be used With antifatigue, constitution can also become better and better.

The various cosmetic health products sold on the market now, the good and bad jumbled together for drug, and most of is all businessman's amusement, is not had Any effect, and the huge injury of human body can be caused.Chinese medicine beauty, weight-reducing, have it is nontoxic, can be fully absorbed by organism Advantage is the Main way that we study.There is an urgent need to develop one kind in present market reducing blood lipid, antibacterial, hypoglycemic, antioxygen Change, the health products of whitening spot-removing effect, and develop trollflower cosmetic health product just meeting it is nontoxic, can be fully absorbed by organism Advantage has huge market potential.

The content of the invention

The technical problems to be solved by the invention are that the living and diet of modern people is excessively fine, amount of exercise reduce or It eats and drinks immoderately or overstrain so that body metabolism function gradually fails, and causes visceral dysfunction, easily causes facial Huang The pigmented lesions such as foxiness, freckle；And modern metropolitan cities working clan generally uses computer office, regards long, tobacco and wine are immoderate, night It lives the behavior of the uncontrolled injury liver such as stay up late, eyes are subject to the provisions of blood that could regard object, and excessively with eye, liver blood can be made Virtual loss makes binocular cannot get the supply of nutrition, so as to go out to lose face it is dry and astringent, see thing obscure, yctalopia etc..In addition, long-term sitting is used Eye, in addition to binocular blood supply insufficiency, cervical vertebra, lumbar vertebrae can also generate strain, also liver must can be damaged less than alleviation.City The various cosmetic health products that face is sold, the good and bad jumbled together for drug, and most of is all businessman's amusement, without any effect, and can be made Into the huge injury of human body；And take that Chinese medicine is cumbersome, and mouthfeel is bad, unsuitable long-term use of, effect is also not necessarily preferable.

In order to solve the above technical problems, the present invention provides a kind of trollflower health care oral liquid for beauty treatment of invigorating blood circulation, the gold It can include the bulk pharmaceutical chemicals of following parts by weight in lotus flower health care oral liquid：10~50 parts of trollflower, 10~20 parts of mulberries, Caulis Spatholobi 10~20 parts, 10~20 parts of mulberry leaf, 10~20 parts of gynostemma pentaphylla, 10~20 parts of Radix Paeoniae Alba, 10~20 parts of Radix Angelicae Sinensis, motherwort 10~20 Part, 10~20 parts of lucid asparagus, 10~20 parts of lotus seeds, 10~20 parts of wrinkled giant hyssop, 10~20 parts of cape jasmine, 10~20 parts of purple perilla, matrimony vine 10 ~20 parts, 10~20 parts of Flos Albiziae, 10~20 parts of Asian puccoon, 10~20 parts of Rhizoma Atractylodis Macrocephalae, 10~20 parts of Radix Rehmanniae, 10~20 parts of korean pine seed, 10~20 parts of stringy stonecrop.

The trollflower health care oral liquid of the promoting blood circulation beauty treatment, can also include in the trollflower health care oral liquid following The bulk pharmaceutical chemicals of parts by weight：10~30 parts of trollflower, 10~15 parts of mulberries, 10~15 parts of Caulis Spatholobi, 10~15 parts of mulberry leaf, gynostemma pentaphylla 10~15 parts, 10~15 parts of Radix Paeoniae Alba, 10~15 parts of Radix Angelicae Sinensis, 10~15 parts of motherwort, 10~15 parts of lucid asparagus, lotus seeds 10~15 Part, 10~20 parts of wrinkled giant hyssop, 10~20 parts of cape jasmine, 10~20 parts of purple perilla, 10~20 parts of matrimony vine, 10~20 parts of Flos Albiziae, Asian puccoon 10 ~20 parts, 10~20 parts of Rhizoma Atractylodis Macrocephalae, 10~20 parts of Radix Rehmanniae, 10~20 parts of korean pine seed, 10~20 parts of stringy stonecrop.

The trollflower health care oral liquid of the promoting blood circulation beauty treatment, can also include in the trollflower health care oral liquid following The bulk pharmaceutical chemicals of parts by weight：10~50 parts of trollflower, 10~20 parts of mulberries, 10~20 parts of Caulis Spatholobi, 10~20 parts of mulberry leaf, gynostemma pentaphylla 10~20 parts, 10~20 parts of Radix Paeoniae Alba, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of motherwort, 10~20 parts of lucid asparagus, lotus seeds 10~20 Part, 10~15 parts of wrinkled giant hyssop, 10~15 parts of cape jasmine, 10~15 parts of purple perilla, 10~15 parts of matrimony vine, 10~15 parts of Flos Albiziae, Asian puccoon 10 ~15 parts, 10~15 parts of Rhizoma Atractylodis Macrocephalae, 10~15 parts of Radix Rehmanniae, 10~15 parts of korean pine seed, 10~15 parts of stringy stonecrop.

In order to solve the above technical problems, the present invention also provides a kind of preparation sides of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation Method, the preparation method of the health care oral liquid comprise the following steps：

A. the extraction of trollflower, as component 1；

B. the preparation of other raw materials, as component 2；

C. above two extracting solution component 1 and component 2 are merged, dextrin or honey is added after concentration, is prepared after disinfection Into health care oral liquid.

In the step a, chopping can be dried after summer picking trollflower, be impregnated and be placed in lid stainless steel barrel It is interior, add 70% ethanol, quality is coarse grained 0.8-1 times, is stirred evenly, moisten it is closed place 1 it is small when more than, make abundant swollen It is swollen；The drug sample moistened after expanding is mixed pine again after filter plate gauze bag package in percolator bottom is paved to do to dissipate, Ran Houyong Stainless steel spoon contains powder, is uniformly packed into percolator, fills 10-12 cm thicks, pressed with T-bar it is even, then by aforesaid operations, in layer Loading, appropriate to pressurize, medicinal powder loads 2/3 eminence that must not exceed percolator；Medicinal powder face upper cover stainless steel plate fastens, and opens Baiting valve below percolator, and a container is put, then it is slowly added into 70% ethanol；Sky between medicinal powder powder to be discharged Gas, and have ethyl alcohol flow out about 20L or so, close baiting valve, cover cylinder of filtering, dipping 24 it is small when, then open baiting valve carry out diacolation, Control diacolation speed is generally 1000g medicinal materials 2~3ml of outflow per minute, and filtrate is put into liquid container, and by ethyl alcohol when emptying Liquid pours into liquid container；Percolate is merged and is stood, stand for standby use, as component 1.

In the step b, remaining raw material can be steeped in 10 times of amount ethyl alcohol after 2-3 days, heating extraction 2 times, each 1-2 Hour, supernatant is removed, merges extracting solution, the filtration of 100-110 mesh, then surpasses through the ultrafiltration column that molecular weight is 6000-10000 that shuts off Filter, ultrafiltrate be concentrated under reduced pressure relative density for 80 DEG C when 1.25 filtrate, stand for standby use, into component 2.

In the step c, two kinds of extracting solutions of above-mentioned steps extraction can be put into economic benefits and social benefits vacuum concentrator and be mixed, When first concentrating the filtrate to 80 DEG C relative density be 1.32 concentrate, set to 0~5 DEG C of deepfreezes 24 it is small when；Refrigeration liquid is added 0.3% filter aid diatomite, filtering, filtrate insert in economic benefits and social benefits vacuum concentrator, are concentrated into every 1ml medicinal extract containing 0.1g, add again Dextrin or honey reconcile, and health care health care oral liquid is prepared into after disinfection.

In order to solve the above technical problems, the present invention provides a kind of preparation side of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation again Method, the preparation method of the trollflower health care oral liquid can also comprise the following steps：

A. the preparation of trollflower, as component 1；

B. it regard remaining bulk pharmaceutical chemicals chopping extraction as component 2；

C. component 1 and component 2 are mixed, after concentration plus appropriate propolis reconciles, and bottles after ultraviolet ray sterilization bactericidal.

In the step a, the trollflower of acquisition can be steeped in 10 times of amount ethyl alcohol after 1 day, heating extraction 2 times, every time When 1-2 is small, supernatant is removed, merges extracting solution, 100-110 mesh filters, then through the ultrafiltration column that molecular weight is 6000-10000 that shuts off Ultrafiltration, ultrafiltrate be concentrated under reduced pressure relative density for 80 DEG C when 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, into component 1。

In the step b, remaining raw medicinal material can be mixed, shred 100~120 mesh sieves, fine powder is spare after sieving, Coarse granule is put into acid and alkali-resistance infusion kettle, at room temperature, impregnates 2-3 days together with 70 degree or more ethyl alcohol, then heating and refluxing extraction 2 It is secondary, every time 1~2 it is small when, No. 2 extracting solutions are merged and are stood, filtering takes filtrate after separation；With filtered through gauze, added in residue 50-60% ethyl alcohol, 60 DEG C -70 DEG C are continued to extract 2h, and per 10min, once, filtered through gauze merges leaching liquor, is condensed into paste for stirring Shape becomes component 2；In the step c, 1 component 2 of component can be mixed, ethyl alcohol is recovered under reduced pressure and is concentrated into liquor strength be 0.6g crude drugs/mL, after suction filtration, 1.36 when the relative density of filtrate is about 20 DEG C；Temperature adds propolis to 60 DEG C -70 DEG C of medicinal extract Oral liquid is made in the ultraviolet sterilization that reconciles.

The present invention is primary raw material using trollflower.The present invention is nourishing liver and kidney, beneficial cloudy blood-nourishing, qi-restoratives strengthening the essence gas, wind-dispelling is bright Mesh, it is nourishing liver and kidney the effect of, specific aim is stronger.The present invention is entirely the health products of green and healthy environmental protection.In addition some promoting blood circulationizations The stasis of blood, inrigorating qi and promoting blood circulation, soothing liver-qi stagnation, calming the liver, enriching yin and nourishing kidney, clearing heat and detoxicating, clearing heat-fire natural traditional Chinese medicine, strengthening vital QI to eliminate pathogenic factors, Logical internal organs lets out poison, and promoting blood circulation to remove blood stasis adjusts the metabolic function of human body, improves blood circulation of human body and liver detoxification ability, reach Beautify the effect of skin.The beneficiating ingredient of the invention greatly remained in trollflower, makes it not have work in-process loss, is making Secondary pollution is avoided in work, is entirely the cosmetic health product of green and healthy environmental protection.

Specific embodiment

Everybody has a love of beauty, after especially our living conditions substantially improve, be even more to beautiful pursuit it is diligent not It is tired.Current many beauty methods are the of short duration cosmetic results to sacrifice the holistic health of people to exchange local for, and this method is not The beautiful appearance of a people can be kept for a long time.So as to make one to generate dependence to whatsit.These methods are simultaneously worth choosing.Beauty Beauty treatment the best way is to be careful in one's diet in daily life, rule of life, environmental factor.Aid in being equipped with the maintenance of beauty class again Product.Easily unconsciously achieving the purpose that beauty.Face is nursed and modified using various cosmetics, it can only Primary beauty concept is deserved to be called, and beauty treatment should be nursed one's health from inside, make gloss of having rosy cheeks, skin is fine and smooth, and binocular has God, so as to reach beautification appearance, often the benefits of guarantor's youth.

Chloasma, chloasma hepaticum are diseases caused by long-term factors.The activity decline of skin tyrosinase, melanin are thin Endosome quantity increases, and wherein oxygen radical is the one of the major reasons that chloasma is formed.It is most important in body antioxidant system Be antioxidase effect, wherein SOD is one of most important enzyme.After this result of study shows modeling, animal skin and liver The MDA contents of tissue improve, and SOD contents reduce, with normal group comparing difference highly significant (P ＜ 0.01).After treatment, MDA contains Amount decreases, and SOD contents increase, compared with model group, significant difference (P ＜ 0.05, P ＜ 0.01)；Wherein, it is heavy dose of Treatment group is notable (P ＜ 0.05) with positive controls comparing difference.Thus prompt spot-removing beautifying face oral liquid of the present invention that can remove oxygen Free radical simultaneously reduces free radical generation；Pathologic examination shows that it can be obviously improved histiocytic pathological change, mitigates Epithelial hyperplasia mitigates the expansion of skin corium thin vessels, reduces inflammatory cell number；Immunohistochemistry detection shows that it can obviously reduce Melanin positive cell number and optical density in epithelial layer.Show that spot-removing beautifying face oral liquid has freckle removing and whitening effect.

Liver controlling conveyance and dispersion refers to the comprehensive physiological functions such as irritability has dredging, item reaches, liter is sent out, freely lets out.Ancients are rushed with wood gas With item up to it as carrying out the catharsis function of analogy liver, therefore wood is belonged in the five-element, therefore《The blue secret allusion quotation opinion of Plain Questions spirit》It says： " liver person, organ of general, consider here ",《Plain Questions six saves state of internal organs opinion》It says：" liver person, source of endurance, the residence of soul ".Liver master dredges The function of letting out is mainly manifested in the spiritual feelings will of adjusting, promotes to digest and assimilate and maintains qi and blood, three aspect of the operation of body fluid.

Liver opening at eye, it is foster that objective vision function relies primarily on moistening for the moon blood of liver；The passages through which vital energy circulates of liver and first line of a couplet mesh system.Cause This, the function of liver normally whether usually reflected on mesh.Such as：Deficiency of liver-blood may occur in which blurred vision, yctalopia；Liver-yin loses It damages, then two xerophtalmias, hypopsia；Liver-fire flaming, then red eye, swell pain.The traditional Chinese medical science emphasizes that people wants frequent dispersing liver-energy, the poison that clears liver, drop Irascibility, nourishing the liver blood, dispersing liver-energy can make whole body mechanism of qi catharsis unobstructed, in vivo without acne on not stifled then face；Clearing liver poison can dissolve elimination body Interior pollution, internal nontoxic then face is without dead color；Reducing liver heat can make internal equilibrium between yin and yang, and not burnt then skin moisturizing is not dry in vivo；Nourishing the liver Blood can nourish whole body internal organs, and it is flexible that liver blood fills then body surface gloss.Damaged liver is repaired, makes whole body mechanism of qi free flow of qi, The smooth operation of whole body qi and blood, to reach soothing the liver beauty treatment purpose.Toxigenic source is liver.When liver cannot complete to detoxify well During work, toxin is just stretched in vivo.Soothing the liver beauty treatment is started with first from liver health, and the liver of health is allowed to complete every removing toxic substances work Make, thoroughly cut off toxin source, make appearance persistently beautiful.

Trollflower is containing alkaloid, flavonoids.Flower (veratric acid) containing veratric acid, orientoside (orientin), Vitex negundo var cannabifolia Glucoside (vitexin), Li Lu amides (veratramide), palmitic acid (palmitic acid).Treat respiratory inflammation：By lily feet Tablet is made in flower, and every content is equivalent to dry 1.5 grams of trollflower, takes day 3 times, every time 3~4；Or injection is made, every 2 milliliters, it is equivalent to 2 grams of trollflower, intramuscular injection, daily 1~2 time, every time 1.Sense, tonsillitis, pharyngitis, urgency are slow in treatment Property tracheitis and other inflammation meters 536, as a result effective (symptom disappears, recovery from illness army are almost recovered) 329 accounts for 61.3%；Have Effect (symptom mitigates, and sb.'s illness took a favorable turn) 135, accounts for 25%；Invalid 72.Wherein to acute and chronic tonsillitis, pharyngitis and upper sense etc. Effect is preferable, poor to chronic bronchitis effect.The effect of tablet, may be related with dosage like injection is higher than.Trollflower acid Water extracts, and is turned to carry the extract of gained with chloroform again after alkalization, has inhibitory action to gram-positive cocci and negative bacillus, It is particularly evident to the antibacterial action of Pseudomonas aeruginosa.The pneumococcus or staphylococcus aureus of mouse infection lethal dose, with 1: 2 The Chinese globe flower injection 0.5 of concentration and 0.2 milliliter, have no Protective effect；But it is clinically used for tonsillitis, pharyngitis, upper sense Deng 226, effective percentage also has certain curative effect up to 92.7% to urinary infection etc..Chmice acute and the subacute experiment of rabbit are all Show that its parenteral solution toxicity is very low, the injection site of only Some Animals has obvious stimulation reaction, to Liver and kidney function and blood picture, all It has no significant effect, the pathological examination of pluck, also without substantially changeing.

Mulberry leaf are the dried leafs of moraceae plants mulberry.It is harvested after first frost, removes impurity, dry and obtain, be a kind of diverging wind-heat Medicine, both oral administrations also can external application.Its is cold in nature, sweet in flavor, bitter, there is the effect of dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clear liver and improve vision, and can treat Anemopyretic cold, lung-heat type cough, dizziness headache, the dim-sighted illness of hot eyes.In modern times, doctor trained in Western medicine using mulberry leaf and mulberry leaf biological agent as Improve the drug of diabetes and other various difficult and complicated cases and use, it is believed that its drug effect is extremely wide.Have clearing away the lungheat and moisturizing, cough-relieving, It reduces phlegm and internal heat, resolving sputum, control night sweat；Tonifying liver clears liver and improve vision, treats dizzy, insomnia, eliminates eye strain；Subside a swelling, purify the blood ' treatment Dysentery, abdominal pain, weight-reducing, except tinea pedis, the large and small intestines of profit；Resisting stress, cool blood, lowering blood pressure and blood fat, prevention myocardial infarction, brain overflow Blood, headache of dispelling, long hair；Hypoglycemic, anti-sugared disease etc..

Rhizoma imperatae, Chinese medicine name.For grass cogongrass Imperata cylindrica Beauv.var.major (Nees) dry rhizome of C.E.Hubb..Spring, the excavation of two season of autumn, clean, dry, remove fibrous root and film quality leaf sheath, be bundled into small .Return lung, stomach, bladder warp.Cooling blood and hemostasis, reducing fever and causing diuresis.It cures mainly and spits blood for blood-head, bleeding from five sense organs or subcutaneous tissue, hematuria, pyreticosis polydipsia, lung heat Cough, gastropyretic vomiting, jaundice with damp-heat pathogen, oedema oliguria, puckery pain of heat gonorrhea.

Cape jasmine (scientific name：Gardenia jasminoides Ellis) alias：Yellow Fructus Gardeniae, mountain Cape jasmine, white toad are that Rubiaceae is planted The fruit of object cape jasmine.The fruit of cape jasmine is traditional Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that the Ministry of Public Health promulgates, has protect liver, profit The effects that courage, decompression, calmness, hemostasis, detumescence.It is usually used in treating icteric hepatitis, bruise, hypertension, sugar in tcm clinical practice Urinate the diseases such as disease.The base of glycosides containing safran, can make weld.

Motherwort acrid flavour is bitter, cool, invigorates blood circulation, silt of dispelling, menstruation regulating, disappear water, treats menoxenia, threatened abortion difficult labour, afterbirth is not Under, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria rushes down blood, carbuncle swells sore.Motherwort has inducing diuresis to remove edema, shrinks uterus work Effect is the key medicine that ancient Chinese medicine doctor is used for treating gynaecological disease.Motherwort can all herbal medicine, active ingredient for motherwort element, Motherwort is containing a variety of alkaloids and benzoic acid, potassium chloride etc. such as leonurine, stachydrine, leonuridine, leonurinines.Motherwort Preparation plays the role of excited animal uterus, similar to pituitrin, and Herba Leonuri extractum and decoction have uterus strong and lasting Excitation, can not only enhance its convergent force, while its tensity and shrinking percentage can be improved.

With joyous flower containing silk tree glucoside, tannin, resolving stagnation for tranquilization, nourishment for vitality, qi-regulating appetizing, active pain relieving is used for, melancholy is lost It sleeps.It is uncomfortable in chest to control pent-up, has a sleepless night, forgetful, acute conjunctivitis, can five viscera settling and will, please color, have preferable salubrity, calmness, tranquilizing the mind, The effect of beauty is the neurasthenic good merchantable brand for the treatment of.With clearing away summerheat, face-beautifying and spot-removing relieves the effect of alcohol and other effects.The traditional Chinese medical science thinks：Silk tree Flower nature and flavor sweet and neutral, Shu Yu, qi-regulating, tranquilizing the mind, active, blood-nourishing, enriching yin kidney, clear away heart-fire improving eyesight.《Sheng Nong's herbal classic》：" silk tree, peace five Dirty and will makes us happy carefree.”

Selfheal is pungent, bitter, trembles with fear.Return liver, gallbladder channel, effect；Clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating.Red eye, swell pain, headache are dizzy Dizzy, mesh pearl nyctalgia.This product bitter cold master enters Liver Channel, is apt to purge the green with improving eyesight.With liver-fire flaming is controlled, red eye, swell pain can match somebody with somebody mulberry leaf, gold Lotus flower, cassia seed etc. are medicinal.Among this product is clear liver and improved vision, slightly simultaneous nourishing the liver, with Radix Angelicae Sinensis, the fruit of Chinese wolfberry, available for deficiecny of liver-YIN, mesh pearl Pain, until night is more particularly；Also rhizoma cyperi can be matched somebody with somebody, Radix Glycyrrhizae is used, as selfheal dissipates (《Zhang Shi doctors are logical》).

Cloudy receipts sweat is held back in Radix Paeoniae Alba nourishing blood and liver, analgesic in delaying.Control chest and abdomen pain over the hypochondriac region, diarrhea dysentery abdominal pain, spontaneous sweating, the deficiency of Yin Fever, irregular menstruation, uterine bleeding, under.《Japan hanako materia medica》：It " controls wind and mends consumptive disease, all diseases of main woman, and antenatal rear all diseases, lead to the moon Water, relieving restlessness of bringing down a fever, QI invigorating control the hot disease of day row, and pest miasma is shied mad, and married woman's blood fortune and intestines wind rush down blood, hemorrhoid complicated by anal fistula carbuncle on the back, sore scabies, headache, Improving eyesight, hot eyes, the triangular mass of mucous membrane growing from the inner corner of the eye." radix paeoniae alba extraction has apparent antagonism, energy to hepatic injury caused by D-galactosamine and SGPT rises SGPT is reduced, and the lesion of liver cell and the ethanol extract of the normal Radix Paeoniae Albas of necrosis recovery is enable to cause aflatoxin B1 The lactic dehydrogenase that is showed of acute liver injury of rats and isoenzymes gross activity rise be minimized white peony root's total glycosides can Inhibit carbon tetrachloride induced mice Plasma glutamate-pyruvate transaminase and lactic dehydrogenase rise, and acid denaturation is bitten to liver organization, necrosis has centainly Antagonism it is believed that, the hepatic injury caused by carbon tetrachloride be because membrane structure occur peroxidation due to destroy, make Glutamic-pyruvic transaminase and lactic dehydrogenase rise in blood, white peony root's total glycoside may have protective effect to hepatocellular injury, therefore can make Transaminase reduces

Mulberries traditional Chinese medicine thinks that mulberry fruit is sour, cold nature, has and improves the immunity of the human body, enriching yin of enriching blood, promotes the production of body fluid Quench the thirst, ease constipation dispel it is dry and other effects, cure mainly deficiency of YIN-blood and cause have a dizzy spell, tinnitus palpitaition, irritated insomnia, soreness and weakness of waist and knees, palpus Hair is early white, quench one's thirst only do, dry and hard excrement, nourishing yin and supplementing blood, improving eyesight are calmed the nerves, sharp joint, curing rheumatism, are relieved the effect of alcohol and other effects.Anti- hemostatic tube Hardening：Contain aliphatic acid in mulberry fruit, mainly by linoleic acid.Stearic acid and oleic acid composition, have and reduce fat, reduce blood fat, prevent The effects that hemostatic tube hardens.

Caulis Spatholobi property is bitter, sweet, warm.Return liver and kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, blood deficiency chlorosis is numb Paralysis, arthralgia pain due to rheumatism are activated blood and relaxed tendons；Nourishing blood for regulating menstruation,《A Supplement to the Compendium of Materia Medica》Carry its can cure it is numb in every limb；Quadriplegia；Rheumatism numbness Bitterly；Women has through uncomfortable；Dysmenorrhoea.External application is the gynaecology's good medicine to activate blood circulation and disperse blood clots.

Eclipta prostrata has the effect of convergence, hemostasis, filling liver kidney.Binomial nomenclature：Eclipta prostrata.To nourish convergence Medicine has the work(of astringing to arrest bleeding apocenosis, can control the diseases such as various haematemesis, enterorrhagia.It smashes juice and applies eyebrow hair, hair growth can be promoted, taken orally There are black hair, dark hair effect.

Radix Angelicae Sinensis, sweet in flavor and weigh, therefore can specially enrich blood, gas is light and pungent, thus again can promoting circulation of blood, bowl spares has, has benefit in row, really Gas medicine in blood, the also panacea in blood.About assistant is then mended with mending, therefore can support nutrition blood, tonifying Qi production of sperm, five viscera settling, strengthen body, Beneficial mind, all tangible deficient diseases are omni-benefiting.Assistant to attack, lead to, therefore the pain defaecation that can dispel, relieving rigidity of muscles and joints, control contraction, paralysis, The cards such as dry, puckery.Battalion is empty and exterior syndrome being not relieved person, helps with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can dissipate Biao Weire greatly, and table does not hold back person, helps with rheum officinale Etc, and can solid table.Precisely because gas Xin Erdong, therefore its quiet person is intended to when keeping away it, property slides benefaction, and the person admittedly that defecates, which works as, keeps away it.In all the moon Fiery Sheng person, the active blood of Radix Angelicae Sinensis, also it is non-preferably, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis energy blood-nourishing, is indispensable.

Gynostemma pentaphylla is mostly important, has following Chinese medicine characteristic：It arranges in pairs or groups to boil water with ganoderma lucidum with gynostemma pentaphylla or brews up, can treat The diseases such as hypertension, hyperlipidemia, hyperglycaemia, fatty liver.There is the effect of protecting liver and detoxication, lowering blood pressure and blood fat blood glucose.Gynostemma pentaphylla is main Effective ingredient is gynosaponin, gynostemma pentaphylla glucoside (polysaccharide), water-soluble amino acids, flavonoids, multivitamin, micro member Element, minerals etc..Medicine elementary source：For the herb of cucurbitaceous plant gynostemma pentaphylla.Nature and flavor：Bitter；Micro-sweet；It is cool in nature.Channel tropism：Return lung； Spleen；Kidney channel.Effect：It replenishes qi to invigorate the spleen, preventing phlegm from forming and stopping coughing is clearing heat and detoxicating.Effect is classified：Qi-restoratives medicine；Apophlegmatisant；Antipyretic.It cures mainly：Body It is empty weak；Nephrasthenia emission；Leukopenia；Hyperlipidemia；Virus hepatitis；Chronic gastroenteritis；Chronic bronchitis.

Lucid asparagus, (Classification system：Asparagus cochinchinensis (Lour.) Merr), alias：Asiatic toddalia root-bark, it is military Bamboo cures mainly fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung carbuncle, and abscess of throat is quenched one's thirst, constipation, difficult urination.It is for oral administration：Decoct soup, 2-4 Money；It endures cream or enters ball, dissipates.Cold of insufficiency type diarrhea and the cause person of coughing that catches cold avoid.The root tuber of lucid asparagus is common Chinese medicine, there is enriching yin profit It is dry, relieve inflammation or internal heat cough-relieving the benefits of.Chinese medicine uses the root tuber of liliaceous plant lucid asparagus.With following pharmacological action it is anti-oxidant, delay Aging lucid asparagus extract plays an important role of to slow down aging, and lucid asparagus polysaccharide, which has, removes free radical and inhibition of lipid peroxidation. Hypoglycemic lucid asparagus Jiangtang capsule can be substantially reduced the blood glucose of alloxan induced hyperglycemia mice.Antibacterial decoction in vitro to bacillus anthracis, A type and beta hemolytic streptococcus, corynebacterium diphtheriae, diphtheroid, Diplococcus pneumopniae, staphylococcus aureus, lemon yellow Portugal Grape coccus, staphylococcus albus and hay bacillus have different degrees of bacteriostasis.In vitrocytotoxicity assay (methylene blue method and watt Family name's respirator measures), lucid asparagus is to acute lymphoblastic type leukaemia, chronic myelocytic leukemia and Acute monocytic type The dehydrogenase of leukaemic's leucocyte has certain inhibitory action, and it is thin in vain to inhibit acute lymphoblastic type leukaemic The breathing of born of the same parents.Kobadrin verifies there is antibechic and phlegm is gone to act on through animal experiment.

Lotus seeds, Chinese medicine name.For the dry mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn..Distribution In China north and south each province.With tonifying spleen and stopping diarrhea, the effect of stop-band, the puckery essence of kidney-nourishing, mental-tranquilization.It is usually used in splenasthenic diarrhea, under, Seminal emission, palpitation and insomnia.

Wrinkled giant hyssop is pungent, tepor.Returns spleen, stomach, lung channel.Function eliminates dampness with aromatics and middle preventing or arresting vomiting with curing mainly, delivers relieving summer-heat.For wet Turbid middle resistance, the vomiting of gastral cavity ruffian, summer-heat and damp exterior syndrome, damp-warm syndrome is from the beginning of burnout of generating heat is uncomfortable in chest not relax, and cold-dampness closes heat, and abdominal pain is vomited and diarrhoea, nasosinusitis head Bitterly.Wrinkled giant hyssop has sterilizing function, and one leaf of mouth containing can remove halitosis, keep off infection, and can serve as preservative.Summer cooked congee with wrinkled giant hyssop or It makes tea drink-service, to summer-heat and damp severe, taste dampness, abdominal fullness and distention, limbs are stranded again, and nausea and vomiting are effective

Rhizoma Atractylodis Macrocephalae (zh ú), Classification system Atractylodes macrocephala.Alias small wooden raft Ji, Yu Shu, winter Rhizoma Atractylodis Macrocephalae, wash rice Art, poplar small wooden raft, Wu Shu, piece art, rhizoma atractylodis etc. belong to composite family, [WTBX herbaceos perennial.The nice and cool weather of happiness, is used as medicine with rhizome, With multinomial medicinal function.It is distributed mainly on the mountain areas such as Sichuan, Yunnan, Guizhou wetland.Rhizoma Atractylodis Macrocephalae has strengthening the spleen and replenishing qi, eliminating dampness profit The effect of water, hidroschesis, tocolysis, for spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.《Medicine opens Source》It records：" the dry and middle QI invigorating of dehumidifying benefit, middle benefit gas, go it is wet in taste, except stomach energy, strong taste, into diet, tocolysis.”

Matrimony vine is the traditional Chinese medicine in China, has consequence in Chinese medicine field.Ningxia is as the genuine production of matrimony vine Area, matrimony vine plantation is with a long history, rich in matrimony vine breeding, cultivation, processing etc. achievement.In recent years, new matrimony vine kind and Matrimony vine breeding method continues to bring out, but the primary evaluation index of matrimony vine kind is in terms of large fruit, high yield type at present, in matrimony vine Research in terms of medicinal ingredient and pharmacological action is deep not enough.5 matrimony vine new varieties of this research comparative analysis and control material Expect the influence to small white mouse anti-fatigue ability and hypoxia-bearing capability.The result shows that different Chinese wolfberry fruit Normal juice are improving small white mouse Antifatigue and hypoxia-bearing capability in terms of significant effect, different matrimony vine material results differ greatly, wherein with 06-16,04-03- The effect of 32 kinds is most apparent, and reason must also be furtherd investigate.Liver is synthetic cholesterol and the most place of neutral fat. The substances such as the organic germanium of the fruit of Chinese wolfberry can protect liver, inhibit fat and hoarded in liver, promote the activation of liver cell, maintenance Impaired liver cell.[6]

Purple perilla can dissipate exterior cold, and sweating power is stronger, for chill table disease, see the diseases such as aversion to cold, fever, lossless, often same with ginger With；If table disease has the stagnation of the circulation of vital energy concurrently, have with rhizoma cyperi, dried orange peel to be equal and use.The wide middle perilla leaf of promoting the circulation of qi is for the taste stagnation of the circulation of vital energy, uncomfortable in chest, evil of vomitting. Perilla leaf be it is a kind of in the widely used delicious flavouring in southern china Zhanjiang Wuchuan area, people usually with its leaf come It cooks, its deliciousness is often mentioned in the same breath with clam beach wormwood

Asian puccoon nature and flavor：Hardship is trembled with fear.Channel tropism：Enter percardium, Liver Channel.Major function：Cool blood, promoting blood circulation, heat-clearing, removing toxic substances.Control warm Macula, jaundice with damp-heat pathogen, purpura spit, are defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, large carbuncle.《This warp》：" the main heart Abdomen perverse trend, five subcutaneous ulcers, tonifying middle-Jiao and Qi, sharp nine orifices, waterway.”《It does not record》：" treat the full pain of abdomen swelling.To close cream, children's sore and face are treated Cha.”《Haigoushen》：" control malignant sore, Guo tinea.”

Korean pine seed, Chinese medicine name.For the seed of pinaceae plant Korean pine Pinus koraiensis Sieb.et Zucc..Distribution In the Northeast.With moisturizing, the effect of blood-nourishing, wind-dispelling.It is usually used in dryness of the lung dry cough, stool is empty secret, and all public attention are dizzy, joint wind, Wandering arthritis.And have moist skin, apply the function of Rong Maofa.

Stringy stonecrop, Chinese medicine name.For the drying herb of crassulaceae plants stringy stonecrop.It is sweet, light, it is cool.There are removing dampness through diuresis and removing jaundice, heat-clearing solution The effect of malicious.It is usually used in jaundice with damp-heat pathogen, difficult urination, carbuncle swells sore.

Specific embodiment 1：

The preparation of trollflower：The good trollflower of condition is harvested in the 7-8 months, decontamination of winnowing with a dustpan is cleaned, dried；It is white by what is dried Trollflower is put into ethyl alcohol and extracts, as component 1.

The preparation of other raw materials：Other raw materials are steeped in 10 times of amount ethyl alcohol after 2-3 days, heating extraction 2 times, into component 2.

Mixing：The trollflower extract liquor prepared and other raw material extracting solutions are mixed, after concentration, dextrin or honey is added to make For oral liquid.

Specific embodiment 2：

The trollflower of acquisition about 5000g is dried chopping by summer, is impregnated and has been placed in lid stainless steel barrel, adds 70% Ethanol, quality be coarse grained 0.8-1 times, stir evenly, moistening it is closed placement 1 it is small when more than, make fully to expand；By diacolation The drug sample moistened after expanding is mixed pine again after paving and does to dissipate by cylinder bottom filter plate gauze bag package, is then contained with stainless steel spoon Powder is uniformly packed into percolator, fills 10-12 cm thicks, even with T-bar pressure, then by aforesaid operations, loading in layer is fitted Work as pressurization, medicinal powder loads 2/3 eminence that must not exceed percolator；Medicinal powder face upper cover stainless steel plate fastens, and opens under percolator The baiting valve in face, and a container is put, then it is slowly added into 70% ethanol；Air between medicinal powder powder to be discharged, and have second Alcohol flow out about 20L or so, close baiting valve, cover cylinder of filtering, dipping 24 it is small when, then open baiting valve carry out diacolation, control diacolation Speed is generally 1000g medicinal materials 2~3ml of outflow per minute, and filtrate is put into liquid container, and ethanol when emptying is poured into storage Fluid cylinder；Percolate is merged and is stood, stand for standby use, as component 1.By remaining raw material mulberries 1200g, Caulis Spatholobi 1200g, mulberry leaf 1100g, gynostemma pentaphylla 1100g, Radix Paeoniae Alba 1100g, Radix Angelicae Sinensis 1100g, motherwort 1200g, lucid asparagus 1100g, lotus seeds 1100g, wrinkled giant hyssop 1100g, cape jasmine 1100g, purple perilla 1100g, matrimony vine 1100g, Flos Albiziae 1100g, Asian puccoon 1100g, Rhizoma Atractylodis Macrocephalae 1100g, Radix Rehmanniae 1100g, korean pine seed 1100g, stringy stonecrop 1100g are steeped in 10 times of amount ethyl alcohol after 2-3 days, and heating extraction 2 times, each 1-2 is small When, it removes supernatant, merges extracting solution, the filtration of 100-110 mesh, then through the ultrafiltration column ultrafiltration that molecular weight is 6000-10000 of shutting off, Ultrafiltrate be concentrated under reduced pressure relative density for 80 DEG C when 1.25 filtrate, stand for standby use, into component 2.By the two of above-mentioned steps extraction Kind extracting solution, is put into economic benefits and social benefits vacuum concentrator and mixes, and relative density is 1.32 concentrate when first concentrating the filtrate to 80 DEG C, Set to 0~5 DEG C of deepfreezes 24 it is small when；Refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate inserts economic benefits and social benefits vacuum again In inspissator, every 1ml medicinal extract containing 0.1g is concentrated into, propolis or honey is added to reconcile, health care health oral is prepared into after disinfection Liquid.

Specific embodiment 3：

Summer shreds the trollflower of acquisition about 4000g, and the trollflower of acquisition is steeped in 10 times of amount ethyl alcohol 2-7 days Afterwards, when heating extraction 2 times, each 1-2 are small, supernatant is removed, merges extracting solution, the filtration of 100-110 mesh, then is through the molecular weight that shuts off The ultrafiltration column ultrafiltration of 6000-10000, ultrafiltrate be concentrated under reduced pressure relative density for 80 DEG C when 1.36 medicinal extract, heating be concentrated into cream Shape, stand for standby use, into component 1.By remaining raw medicinal material mulberries 1000g, Caulis Spatholobi 1000g, mulberry leaf 1000g, gynostemma pentaphylla 1000g, Radix Paeoniae Alba 1000g, Radix Angelicae Sinensis 1000g, motherwort 1000g, lucid asparagus 1000g, lotus seeds 1000g, wrinkled giant hyssop 1000g, cape jasmine 1000g, purple perilla 1000g, matrimony vine 1000g, Flos Albiziae 1000g, Asian puccoon 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Rehmanniae 1000g, korean pine seed 1000g, stringy stonecrop 1000g, mixing, shredded 100~120 mesh sieves, fine powder is spare after sieving, and coarse granule is put into acidproof alkali steeping Pot, at room temperature, impregnated together with 70 degree or more ethyl alcohol 15~30 days, then heating and refluxing extraction 2 times, every time 1~2 it is small when, No. 2 extracting solutions are merged and are stood, filtering takes filtrate after separation；With filtered through gauze, 50-60% ethyl alcohol is added in residue, 60 DEG C- 70 DEG C are continued to extract 2h, and per 10min, once, filtered through gauze merges leaching liquor for stirring, is condensed into paste as component 2.It will be above-mentioned Two kinds of extracting solutions of step extraction, are put into economic benefits and social benefits vacuum concentrator and mix, relative density is when first concentrating the filtrate to 80 DEG C 1.32 concentrate, set to 0~5 DEG C of deepfreezes 24 it is small when；Refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate is again It inserts in economic benefits and social benefits vacuum concentrator, is concentrated into every 1ml medicinal extract containing 0.1g, propolis is added to reconcile, health care guarantor is prepared into after disinfection Health-care oral liquid.

Pharmacological toxicity is tested

Experimental example 1：Acute toxicity test of the present invention

First, test material：Animal：Kunming mouse, weight 18-25g, half male and half female, biology laboratory breeding.Drug： The present invention (all raw material mixing decocts 2 times, merges filtering, taking liquid) contains 0.0365mg/ml.

2nd, method：

1st, LD50 is calculated：Using improvement karber's method, mouse is randomly divided into 5 groups, every group 10, half male and half female sends out this Bright plus distillation water dissolution, is made into maximum concentration, is administered by the maximum allowable capacity of mouse, and institute is followed successively by 17 to dosage by crude drug amount, 14.2,11.1,9.2,7.2 (g.kg^-1), when animal fasting (can't help water) 18 is small after, (interval is half small for administration at twice in one day When), each 0.5ml observes animal dead situation.

2nd, maximum tolerated dose measures (MTD values)：Take mouse 20, each 10 of male and female.By the present invention plus water dissolution is distilled, Maximum concentration is made into, by the maximal tolerance dose of animal, injection of being subject to, which feeds device, to twitch.It is small in animal fasting (can't help water) 18 Shi Hou, administration (interval half an hour) at twice in one day, each 0.5ml (containing crude drug 0.36g per ml), total dose for 18g crude drugs/ Kg.d, 300 times of quite clinical adult's 50Kg weight dosages.It is observed continuously after administration 7 days.

3rd, result of the test：

In LD50 calculating when giving mouse with maximum acceptable concentration and maximum allowable capacity (18g/Kg.d), have no small Mouse is dead, i.e., does not measure LD50, only seek maximum tolerated dose, in 7 day observation period, animal its appetite, activity, hair color, essence Refreshing state etc. is all normal, and development is normal, there are no death.300 times of doses for being equivalent to clinical dosage are selected, are had no bad anti- It should occur, show that acute toxicity is minimum, MTD ＞ 18g/Kg.d.

Experimental example 2：Animal local excitation is tested：

The allergic reaction on guinea pigs of enema of the present invention and Rat-rectum medication irritation test.

The result shows that：Skin anaphylactic test, high dose group 0.8g (medicinal powder)/kg, low dose group 0.1g (medicinal powder)/kg, point Intend clinical people's dosage [0.04g (medicinal powder)/kg] 20 times, 2.5 times are not equivalent to, through percutaneous drug delivery, are showed no animal and are generated change State is reacted；Rectal application irritation test high dose group 5.0g (medicinal powder)/kg, low dose group 3.2g (medicinal powder)/kg are suitable respectively In 125,80 times of the clinical people's dosage of plan, phenomena such as mucous membrane of rectum is without hyperemia, oedema, pathologic group are observed before the deadline It knits and checks the no significant difference compared with blank control group, have no apparent irritative response occur, the part of every group of retention is moved Its overall health of patients of object, weight, breathing, cycling, central nervous system and four limbs activity etc., equal Non Apparent Abnormality reaction.

Embodiment 3：Long term toxicity test：Toxic reaction whether is generated for observation long-term administration, gives rat this hair respectively Bright servo, by 70 times of adult clinical daily dosage and 35 times (i.e. 7g/kg/ days and 3.5g/kg/ days), continuous feeding 8 weeks has no There is abnormal, and control group ratio in the behavior of rat, feed, weight, blood routine, hepatic and renal function, and various important organs are without exception Change, in the range of institute's dosage, not it has been found that any toxicity of the present invention.Pass through the acute and chronic toxicity test of animal It confirms, safe range of the present invention is larger, is a kind of safe and reliable health products.

Pharmacological experiment：

Since ancient times, everybody has a love of beauty.Because the body of health and beautiful appearance be vitality it is vigorous as Sign, these concepts are particularly important for women.Today's society, women bear family with work dual-pressure and often in sub- strong " not sick " state caused by health state namely the so-called constitution of the traditional Chinese medical science are biased.The it is proposed of Constitution Theory in TCM, makes us more close How note adjusts the biased constitution of women to achieve the purpose that the beautiful skin of anti-aging, beauty treatment.We send out in long-term clinical practice Existing, recuperating under medical treatment biased constitution with prescription has good efficacy.This research observation is inquired into from promoting blood circulation face-beautifying oral liquid side made of plan The feasibility for the fixation oral liquid for holding beauty treatment is managed as conditioning obstruction of the circulation of vital energy blood stasis constitution women.

Data and method

First, clinical data

60 cases took our female in the attached SHUGUANG HOSPITAL of university of TCM from December, 2013 to 2 months 2015 Property (outpatient service of preventiveing treatment of disease, medical center and community), 20~50 years old age, average 39.0 years old.Women accounts for 45.4% within 41~50 years old, than Example is maximum, secondly accounts for 43.6% for 31~40 years old women, women accounts for 10.9% within 20~30 years old.

Inclusion criteria：Meet《Traditional Chinese Medicine Constitution Classification is with judging》In the criterion of 9 kinds of constitutions (be associated with hypertension, sugar The chronic diseases persons such as disease, chronic gastropathy are urinated, fixed drug therapy person can be taken during herbal paste is taken and meets inclusion criteria). Exclusion criteria：It is associated with liver, brain, kidney, the heart and hemopoietic system serious disease and psychiatric patient；Gestation or nursing period woman Female；Participating in other clinical trials observer；Compliance difference person.

2nd, method

1. therapy：Take present invention promoting blood circulation face-beautifying oral liquid, basic side's composition：By trollflower, mulberries, Caulis Spatholobi, Mulberry leaf, gynostemma pentaphylla, Radix Paeoniae Alba, Radix Angelicae Sinensis, motherwort, lucid asparagus, lotus seeds, wrinkled giant hyssop, cape jasmine, purple perilla, matrimony vine, Flos Albiziae, Asian puccoon, in vain Art, Radix Rehmanniae, korean pine seed, stringy stonecrop add water or ethyl alcohol to extract.Pharmacy of the court produces.Each 1 time of morning and evening daily, takes 50 altogether ~60d.Avoid during taking and drink, smoke, drinking strong tea, drinking coffee and eating excitant food, raw turnip.

2. observation index：The variation of observational study object constitution situation emphatically judges respectively in our patients before and after intervention constitution Scoring, and statistical analysis is carried out after observation；Observation related symptoms situation and is commented before and after taking promoting blood circulation beauty treatment side Point, and statistical analysis is carried out after observation；Whether observation has adverse events and adverse reaction when taking herbal paste, such as stomach not Phenomena such as suitable, allergy.

3. criterion and curative effect：Constitution criterion is issued according to China Association of Traditional Chinese Medicine《Traditional Chinese Medicine Constitution Classification with Judge》Classification in standard, constitution are divided into 9 types, are gentle matter respectively, deficiency of vital energy matter, deficiency of yang matter, deficiency of Yin matter, phlegm wet matter, damp and hot Matter, blood stasis matter, deficiency of vital energy matter, different official report matter.Wherein except gentle matter, remaining is all biased constitution.Symptom curative effect refers to《New Chinese medicine Guideline of clinical investigations》].Evaluation of clinical curative effect：Recovery from illness：Tcm clinical practice symptom, sign disappear or mostly disappear, disease integration Reduce >=95%.It is effective：Tcm clinical practice symptom, sign improve, and disease integration reduces >=70%.Effectively：Tcm clinical practice symptom, body Sign improves, and disease integration reduces >=30%.It is invalid：Tcm clinical practice symptom, sign are not improved, even it aggravates, disease product Divide and reduce ＜ 30%.

3rd, statistical procedures

Database is established with SPSS17.0 statistical softwares to investigation result, measurement data is represented with x ± s, paired t-test. Enumeration data is with fraction representation, using X²It examines.It is statistically significant for difference with P ＜ 0.05.

As a result

Before and after treatment constitution total score relatively in, the research object obstruction of the circulation of vital energy matter treatment before total score be 20.17 ± 3.821, treatment Total score is 15.45 ± 4.521 afterwards, and post treatment integral is reduced；Total score is 20.53 ± 3.922 before the treatment of research object blood stasis matter, is controlled Total score is 16.34 ± 4.121 after treatment.Pretherapy and post-treatment obstruction of the circulation of vital energy total score and pretherapy and post-treatment blood stasis matter total score difference are statistically significant (P ＜ 0.05) prompts research object constitution after treating to have a degree of improvement before relatively treating.To the obstruction of the circulation of vital energy, blood stasis constitution phase Close in the research compared of symptom integral, symptom integral 41.69 ± 12.732 before treatment, after treatment symptom integral for 25.53 ± 11.283, symptom integral is reduced than prior treatment integral after treatment.The pretherapy and post-treatment obstruction of the circulation of vital energy, blood stasis qualitative correlation symptom integral difference have Statistical significance (P ＜ 0.05), and decrease before relatively being treated after the treatment of each symptom integral, prompt promoting blood circulation face-beautifying oral liquid side There is the effect of certain to the obstruction of the circulation of vital energy, blood stasis constitution related symptoms.Recovery from illness 0, effective 8 (5.45%), effective 31 (56.36%), it is invalid 21 (38.18%).Beauty treatment herbal paste of invigorating blood circulation symptom integral judges clinical efficacy, effective 38 total (63.33%).

After taking promoting blood circulation beauty treatment side, the obstruction of the circulation of vital energy, blood stasis constitution and damage U.S.'s property symptom total mark of research object are calculated again, with And each correlation factor integration, each symptom correlation factor integral contrast after and treatment preceding to treatment, the statistically significant (P of difference ＜ 0.05).After treatment according to《New Chinese medicine guideline of clinical investigations》Standard is evaluated clinical efficacy and is shown, beauty treatment herbal paste of invigorating blood circulation Light to menstruation color, excessive menstruation, menstrual flow is very few, and menstruation color is dark red, and menstruation color is purple dark, and dysmenorrhoea, menstruation is always It delays, it is nervous before and after menstruation, feel depressed, is depressed, flying into a rage, there is clot in menstruation, menstruation always comes in advance, lip face Colour cast is dark, and eyes swell, easily raw acne or boil, menstruation fore udder or side of body rib portion distending pain, easily insomnia, dreaminess, the time that menstruation comes Long, dripping unnet, sallow complexion or white all of a sudden easily has livid ring around eye, face has moth patch, there is lump, tubercle with it, and tongue nature color is dark Or having petechia, therapeutic effect is preferable；And to menstruation irregularis, irregularly, dry skin is coarse successively, and facial or nose has greasy Sense or it is glossy shine, dim complexion or have blackening and the banknote line therapeutic effect general.Irregular menstruation is that damage women appearance is beautiful Immanent cause, in 1 course for the treatment of invigorate blood circulation face-beautifying oral liquid feminine menstrual situation is integrally improved with obvious curative effects, embody On the other hand promoting blood circulation beauty treatment herbal paste " is being cured the disease, the beauty treatment herbal paste that illustrates to invigorate blood circulation in the short period of time is to the women obstruction of the circulation of vital energy, blood stasis constitution The inherent cause of disease improve it is more external damage U.S.'s property symptom improvement it is good, prompt it is external damage U.S.'s property symptom may need it is more macrocyclic Conditioning can be only achieved apparent effect.

It discusses：Women physique characteristic and damage capacitive disease correlation women have through, band, tire, production physilogical characteristics, women Biased constitution there is gas, blood, the inclined of yin, yang and contain or decline partially, will result in many damages appearance based on yin and yang qi and blood disorder Property disease.《Plain Questions ancient times innocent opinion》In several stages of the original text than more fully describing woman's all one's life, where it is proposed female The aging of son in life is since five or seven, and such as " five or seven yangming meridians decline, the face becoming withered, and hair begins to fall；673 Yang Mai decline in upper, Wrinkly face, hair begin white." visible passages through which vital energy circulates yang blood and qi it is unbalance cause appearance, skin, hair even reproductive function progressively fail.It is existing Generation research shows that internal organs, qi and blood functional disturbance are the basic reasons for generating chloasma faciei.So understand the constitution class of women Type, and set about coming maintaining healthy and beauty from constitution adjusting yang blood and qi balance is improved, it is the new neck of current " preventiveing treatment of disease " theory Domain also highlights the characteristic and advantage of constitution theory in traditional Chinese medicine health.

" have Zhu Neibi shapes all outer " is thought in traditional Chinese medical science entirety beauty treatment sight, and people is an organic whole, and face face are whole A part for body, local is beautiful, and dependent on whole equilibrium between yin and yang, internal organs are stabilized, channels and collaterals are unobstructed, qi and blood circulation.It gets rid of illness foster Face class prescription is according to the principle of the traditional Chinese medical science " searching for the primary cause of disease in treatment ", and disappear color spot on the basis for the treatment of gynaecology protopathy, cures the disease and beauty treatment It develops simultaneously.Promoting blood circulation and removing obstruction in channels, enriching yin moisturizing of the invention, tonifies the liver and kidney, the regulation of qi and blood is cured the disease and taken into account with beauty treatment.Women takes individuation Oral liquid, by Heibei provincial opera of the present invention, planning slowly and carefully, long-acting help human liver kidney qi blood, promoting blood circulation and removing blood stasis, nourishing Yin and moistening lung can improve face Portion's blood circulation adjusts the endocrine function gradually to fail, the aging of delaying female, the beautiful skin of beauty treatment.Modern research shows that this hair Bright moisturizing ecchymose removing, has a better effect chloasma, acne, alopecia, also has very to women's facial color spot caused by gynecological disease Good regressive effect.Beautification function of the present invention is stable, lasting, and women is suitable for maintain.In addition, compared with decoction, oral liquid mouthfeel It is good, it is convenient to take, patient is improved using Chinese medicine compliance, it is especially deep to be liked by women.

Claims

1. it is a kind of invigorate blood circulation beauty treatment trollflower health care oral liquid, which is characterized in that the trollflower health care oral liquid include with The bulk pharmaceutical chemicals of lower parts by weight：10~50 parts of trollflower, 10~20 parts of mulberries, 10~20 parts of Caulis Spatholobi, 10~20 parts of mulberry leaf, strand It is 10~20 parts blue, 10~20 parts of Radix Paeoniae Alba, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of motherwort, 10~20 parts of lucid asparagus, lotus seeds 10~20 Part, 10~20 parts of wrinkled giant hyssop, 10~20 parts of cape jasmine, 10~20 parts of purple perilla, 10~20 parts of matrimony vine, 10~20 parts of Flos Albiziae, Asian puccoon 10 ~20 parts, 10~20 parts of Rhizoma Atractylodis Macrocephalae, 10~20 parts of Radix Rehmanniae, 10~20 parts of korean pine seed, 10~20 parts of stringy stonecrop.

2. the trollflower health care oral liquid for beauty treatment of invigorating blood circulation according to claim 1, which is characterized in that the trollflower health care mouth Take the bulk pharmaceutical chemicals that following parts by weight are further included in liquid：10~30 parts of trollflower, 10~15 parts of mulberries, 10~15 parts of Caulis Spatholobi, mulberry 10~15 parts of leaf, 10~15 parts of gynostemma pentaphylla, 10~15 parts of Radix Paeoniae Alba, 10~15 parts of Radix Angelicae Sinensis, 10~15 parts of motherwort, lucid asparagus 10~ 15 parts, 10~15 parts of lotus seeds, 10~20 parts of wrinkled giant hyssop, 10~20 parts of cape jasmine, 10~20 parts of purple perilla, 10~20 parts of matrimony vine, Flos Albiziae 10~20 parts, 10~20 parts of Asian puccoon, 10~20 parts of Rhizoma Atractylodis Macrocephalae, 10~20 parts of Radix Rehmanniae, 10~20 parts of korean pine seed, stringy stonecrop 10~20 Part.

3. the trollflower health care oral liquid for beauty treatment of invigorating blood circulation according to claim 1, which is characterized in that the trollflower health care mouth Taking also includes the bulk pharmaceutical chemicals of following parts by weight in liquid：10~50 parts of trollflower, 10~20 parts of mulberries, 10~20 parts of Caulis Spatholobi, mulberry 10~20 parts of leaf, 10~20 parts of gynostemma pentaphylla, 10~20 parts of Radix Paeoniae Alba, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of motherwort, lucid asparagus 10~ 20 parts, 10~20 parts of lotus seeds, 10~15 parts of wrinkled giant hyssop, 10~15 parts of cape jasmine, 10~15 parts of purple perilla, 10~15 parts of matrimony vine, Flos Albiziae 10~15 parts, 10~15 parts of Asian puccoon, 10~15 parts of Rhizoma Atractylodis Macrocephalae, 10~15 parts of Radix Rehmanniae, 10~15 parts of korean pine seed, stringy stonecrop 10~15 Part.

4. a kind of preparation method of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation as any one of claims 1 to 3, special Sign is that the preparation method of the health care oral liquid comprises the following steps：

A. the extraction of trollflower, as component 1；

B. the preparation of other raw materials, as component 2；

C. above two extracting solution component 1 and component 2 are merged, dextrin or honey is added after concentration, guarantor is prepared into after disinfection Health-care oral liquid.

5. the preparation method of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation according to claim 4, it is characterised in that：The step In rapid a, chopping is dried after summer picking trollflower, is impregnated and has been placed in lid stainless steel barrel, add 70% ethanol, quality For coarse grained 0.8-1 times, stir evenly, moisten it is closed place 1 it is small when more than, make fully to expand；By percolator bottom filter plate The drug sample moistened after expanding is mixed pine again after being paved with gauze bag package to do to dissipate, then contains powder with stainless steel spoon, uniformly Percolator is packed into, fills 10-12 cm thicks, it is even with T-bar pressure, then by aforesaid operations, loading in layer is appropriate to pressurize, medicine Powder loads 2/3 eminence that must not exceed percolator；Medicinal powder face upper cover stainless steel plate fastens, and opens the blowing below percolator Valve, and a container is put, then it is slowly added into 70% ethanol；Air between medicinal powder powder to be discharged, and have ethyl alcohol outflow about 20L or so, close baiting valve, cover cylinder of filtering, dipping 24 it is small when, then open baiting valve carry out diacolation, control diacolation speed it is general For 1000g medicinal materials 2~3ml of outflow per minute, filtrate is put into liquid container, and ethanol when emptying is poured into liquid container；It will Percolate, which merges, to be stood, stand for standby use, as component 1.

6. the preparation method of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation according to claim 4, which is characterized in that the step In rapid b, remaining raw material is steeped in 10 times of amount ethyl alcohol after 2-3 days, heating extraction 2 times, when each 1-2 is small, remove supernatant, merging Extracting solution, the filtration of 100-110 mesh, then through the ultrafiltration column ultrafiltration that molecular weight is 6000-10000 of shutting off, ultrafiltrate is concentrated under reduced pressure phase 1.25 filtrate, stand for standby use, into component 2 when being 80 DEG C to density.

7. the preparation method of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation according to claim 4, which is characterized in that the step In rapid c, by two kinds of extracting solutions of above-mentioned steps extraction, it is put into economic benefits and social benefits vacuum concentrator and mixes, first concentrate the filtrate to 80 DEG C When relative density be 1.32 concentrate, set to 0~5 DEG C of deepfreezes 24 it is small when；Refrigeration liquid is added to 0.3% filter aid diatom Soil, filtering, filtrate are inserted again in economic benefits and social benefits vacuum concentrator, are concentrated into every 1ml medicinal extract containing 0.1g, and dextrin or honey is added to reconcile, is disappeared Health care health care oral liquid is prepared into after poisoning bacterium.

8. a kind of preparation method of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation as any one of claims 1 to 3, special Sign is that the preparation method of the trollflower health care oral liquid can also comprise the following steps：

A. the preparation of trollflower, as component 1；

9. the preparation method of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation according to claim 8, which is characterized in that the step In rapid a, the trollflower of acquisition is steeped in 10 times of amount ethyl alcohol after 1 day, heating extraction 2 times, when each 1-2 is small, removes supernatant, close And extracting solution, the filtration of 100-110 mesh, then through the ultrafiltration column ultrafiltration that molecular weight is 6000-10000 of shutting off, ultrafiltrate is concentrated under reduced pressure 1.36 medicinal extract when relative density is 80 DEG C, heating are concentrated into paste, stand for standby use, into component 1.

10. the preparation method of the trollflower health care oral liquid for beauty treatment of invigorating blood circulation according to claim 8, which is characterized in that described In step b, remaining raw medicinal material is mixed, shredded 100~120 mesh sieves, fine powder is spare after sieving, and coarse granule is put into acid and alkali-resistance Infusion kettle at room temperature, impregnates 2-3 days, then heating and refluxing extraction 2 times together with 70 degree or more ethyl alcohol, every time 1~2 it is small when, No. 2 extracting solutions are merged and are stood, filtering takes filtrate after separation；With filtered through gauze, 50-60% ethyl alcohol is added in residue, 60 DEG C- 70 DEG C are continued to extract 2h, and per 10min, once, filtered through gauze merges leaching liquor for stirring, is condensed into paste as component 2；The step In rapid c, 1 component 2 of component is mixed, ethyl alcohol is recovered under reduced pressure and is concentrated into liquor strength as 0.6g crude drugs/mL, after suction filtration, filtrate Relative density 1.36 when being about 20 DEG C；The medicinal extract of temperature to 60 DEG C -70 DEG C adds propolis reconciliation ultraviolet sterilization to be made oral Liquid.