CN103041070A - Lipid-lowering and pressure-releasing folium ginkgo health-care product and preparation method thereof - Google Patents

Abstract

The invention provides a lipid-lowering and pressure-releasing folium ginkgo health-care product. The health-care product comprises the following raw materials in part by weight: 50-100 parts of folium ginkgo, 10-20 parts of fructus rubi, 10-20 parts of rehmannia glutinosa, 10-20 parts of Chinese angelica, 10-20 parts of dogwood, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of poria cocos, 10-20 parts of dracocephalum heterophyllum benth, 10-20 parts of codonopsis pilosula, 10-20 parts of herba eupatorii, 10-20 parts of gynostemma pentaphylla, 10-20 parts of astragalus mongholicus, 10-20 parts of rhizoma alismatis, 10-20 parts of safflower carthamus, 10-20 parts of scutellaria baicalensis, 10-20 parts of radix paeoniae alba, 10-20 parts of gardenia, 10-20 parts of white atractylodes rhizome, 10-20 parts of glossy privet fruit, 10-20 parts of tartary buckwheat and 10-20 parts of propolis. According to the invention, as the folium ginkgo is extracted, the active ingredients of the folium ginkgo are retained, and the toxicity is reduced; and as the traditional Chinese medicinal materials, which can activate blood and remove stasis and can obviously reduce the blood sugar and fat serum triglyceride, are added, the microcirculation can be improved, the immunity is enhanced, and people can accept easily, as a result, the lipid-lowering and pressure-releasing efficacy can be better achieved. According to the invention, the health-care product cannot be taken by pregnant women and young children.

Description

A kind of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product and preparation method thereof

Technical field

The present invention relates to contain the blood fat-reducing blood pressure-decreasing health product that derive from plant composition, particularly a kind of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product and preparation method thereof.

Background technology

Folium Ginkgo is a kind of plant with very high medical value, and ginkgo is one of ancient seeds of China, and it is the tree of the medical treatment of mystery, Jurassic Period dinosaur control terrestrial time before more than 200,000,000 5 thousand year, and Semen Ginkgo is one of the most flouring plant.Life on earth is gone through the change in 100000000000 years, especially after the glacier covering of the 4th century, only has Semen Ginkgo still to keep its most original looks, is called as " living fossil " in the organic evolution history.Its leaf, fruit, seed have higher medical value, and its pharmacological action constantly is familiar with, and clinical application range progressively enlarges.Ginkgo has another name called maidenhair tree, is the rarity of China, and is rare valuable, is described as " hollywood lignumvitae ", " living fossil " of the earth.

Contain the multiple components useful with health such as natural activity flavone and amarolide in the Folium Ginkgo, has dissolving cholesterol, the effect of blood vessel dilating has positive effect to improving disordered brain function, arteriosclerosis, hypertension, dizzy, tinnitus, headache, senile dementia, hypomnesis etc.Its diseases prevention, cure the disease, the value of body-building is early on the books in the Compendium of Material Medica of Ming Dynasty's Li Shizhen (1518-1593 A.D.).Detect proof through national health department: drink Folium Ginkgo tea and can obviously reduce serum cholesterol, triglyceride and low-density blood lipoprotein, reduce the effect of depot lipid in the body.For fat-reducing of the complementary controls of diseases of cardiovascular and cerebrovascular systems patient such as adjusting, hypertension and the coronary heart disease of hyperlipidemia and obese type crowd etc. good effect being arranged, is the desirable beverage of prophylactic treatment senile dementia.It is the optimal pharmaceutical compositions of cardiovascular and cerebrovascular disease of controlling, prevent recognized in the world.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Though Folium Ginkgo energy blood circulation promoting, the prevention cardiovascular diseases, but can not take simultaneously other and control cardiovascular drugs (for example aspirin), Semen Ginkgo extrac is the concentrated granular shape, have very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.In addition, according to modern clinical research, the chronic schizophrenia take negative symptoms as main (such as social withdrawal, sluggishness, the poverty of thought, the symptom such as dull) there is remarkable result, cerebellar atrophy (senile dementia) is also had certain effect.

The high speed development of Modern Urban Living also brings a series of affluenza.Wherein " three-hypers " and obesity are puzzlement people's primary enemies." three-hypers disease " refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia.Usually be accompanied by obesity.They are " affluenza " that modern society is derived from, and possible individualism also may be interrelated.As: the diabetes patient is easy to suffer from simultaneously hypertension or hyperlipidemia, and hyperlipidemia is the principal element of arteriosclerosis formation and development, the poor aggravation hypertension of arteriosclerotic's blood vessel elasticity, thus the later stage all formed " three-hypers disease ".Be what has statistics about three-hypers, in the Chinese ten large causes of death, the mortality rate relevant with metabolic disease is just up to 35.7%, and the death toll relevant with " three-hypers " also accounts for 27% of total death toll.Hyperlipidemia can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycemia can cause diabetes.World Health Organization (WHO) once clearly proposed, and prevented that cardiovascular diseases's the first line of defence from reducing exactly " three-hypers " and control " three-hypers ".A lot of diabetes patients are with hyperlipemia, so people call sister's disease to diabetes and hyperlipemia usually, and think that hyperlipidemia is the secondary disease of diabetes.About 40% diabetic has disorders of lipid metabolism according to statistics.Being characterized in that triglyceride increases with high density lipoprotein reduces.Diabetes cause that the reason of Lipid increase is because during diabetes patient's insufficient insulin, body lactonase activity lowers, therefore easy Lipid increase.On the other hand diabetes simultaneously also companion's fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance itself.Often there is free fatty from fat depot, to mobilize out, makes triglyceride and free fatty Enrichment in the blood.The type 2 diabetes mellitus people takes food too much on the one hand again, and motion is few, impels synthetic the increasing of the interior lipid of body, and this also is the reason that causes Lipid increase.And fat companion's hyperlipidemia person owing to the Insulin receptor INSR number reduces relatively, thereby produces insulin resistant, easily induced Diabetic.The Lipid increase person also easily causes the heart, cerebrovascular complication.

Folium Ginkgo is with other Chinese herbal medicine compatibility, can bring into play better its blood pressure lowering, blood fat reducing, fall the effect of hyperlipidemia.The effect of vegetable flavonoid in human body, mainly be to strengthen antiotasis, coronary artery dilator, vessel softening, improve vascular permeability, reduce blood pressure, blood fat reducing and cholesterol, anti-platelet aggregation, minimizing thrombosis, reduce endovascular HDL-C (HDL-C), triglyceride (TG), thereby reach blood pressure lowering, blood fat reducing, fall the sticking effect of blood.Vegetable flavonoid is indispensable neccessary composition in the human body, and Six-element flavone tea is rich in flavone, rutin.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, the old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting the blood coagulation situation, not the blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel more can not long-term taking, in order to avoid cause cerebral hemorrhage.Folium Ginkgo can not together brew up with Folium Camelliae sinensis and Flos Chrysanthemi.

Although the ginkgo Leaves health care effect is very strong, Folium Ginkgo contains poisonous composition, and brewing up with it to cause clonospasm, neural paralysis, platycoria, allergy and other side effect.Anemia of pregnant woman and child, old man are careful.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.Semen Ginkgo contains a large amount of ginkgoic acids, ginkgoic acid be contain virose, the leaf of generally buying does not pass through deep processing and extraction, the ginkgoic acid content of the inside is up to 3000-4000ppm, special ginkgoic acid is water miscible, one soaked Semen Ginkgo pyrite and the active substance such as Semen Ginkgo lactone of not only not having the inside, effect is opposite on the contrary, the inside is poison entirely.

Although the ginkgo Leaves health care effect is very strong, Folium Ginkgo contains poisonous composition, and brewing up with it to cause clonospasm, neural paralysis, platycoria, allergy and other side effect.Ginkgoic acid, improper use or dosage are too large, are easy to cause poisoning.So at present in the urgent need to a kind of technique, health-care effect that can the application Folium Ginkgo makes again its poisonous material drop to minimum.Anemia of pregnant woman and child, old man are careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, the old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting the blood coagulation situation, not the blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel more can not long-term taking, in order to avoid cause cerebral hemorrhage.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.

Summary of the invention

Technical problem to be solved by this invention is that there are a lot of defectives in prior art, and at present, blood fat reducing and atherosclerosis health product are more, differ from one another, but also have simultaneously certain deficiency, and are higher such as price, and the patient is difficult to accept; Specific aim is not strong, and therapeutic effect is undesirable etc.; And Folium Ginkgo contains poisonous composition, and brewing up with it to cause clonospasm, neural paralysis, platycoria, allergy and other side effect; A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.The present invention extracts Folium Ginkgo, not only kept its beneficiating ingredient, reduce toxicity, add some blood circulation promoting and blood stasis dispelling, the Chinese crude drug that blood glucose and fatty serum triglycerides is all had obvious reducing effect, can improve microcirculation, improve immunity and make the people be easy to accept, more can reach preferably the effect of blood fat-reducing blood pressure-decreasing.

For solving the problems of the technologies described above, the invention provides a kind of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, the parts by weight of various raw materials are in the described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product: 50～100 parts of Folium Ginkgos, 10～20 parts of Fructus Rubies, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Poria, 10～20 parts of heterophyllum, 10～20 parts of Radix Codonopsis, 10～20 parts of Herba Eupatoriis, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Alismatis, 10～20 parts on Flos Carthami, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Gardeniaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of propolis.

Described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, the parts by weight of various raw materials can be preferably in its described health product: 50～85 parts of Folium Ginkgos, 10～15 parts of Fructus Rubies, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Corni, 10～150 parts of Radix Salviae Miltiorrhizaes, 10～15 parts in Poria, 10～15 parts of heterophyllum, 10～15 parts of Radix Codonopsis, 10～15 parts of Herba Eupatoriis, 10～15 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Alismatis, 10～20 parts on Flos Carthami, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Gardeniaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of propolis.

Described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, the parts by weight of various raw materials also can be preferably in its described health product: 50～100 parts of Folium Ginkgos, 10～20 parts of Fructus Rubies, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Poria, 10～20 parts of heterophyllum, 10～20 parts of Radix Codonopsis, 10～20 parts of Herba Eupatoriis, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Alismatis, 10～15 parts on Flos Carthami, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Gardeniaes, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～15 parts of propolis.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, and the preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product may further comprise the steps:

A. the Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into particulate matter, powder or unguentum;

E. with the agent of surplus stock granulation, powder or unguentum;

F. pack after granule obtained above, powder or unguentum being mixed with the Folium Ginkgo extract of making.

Among the described step a, can get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 8-12h takes out and places cooling in the drying baker, pulverizes 60 mesh sieves with pulverizer, and powder places brown wide mouthed bottle to store.

Among the described step b, can get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution; Then get the 100g ginkgo leaf powder in 700mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 700mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.

Among the described step c, ginkgo biloba succi can be used first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed; The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, after the sucking filtration end, gets filtrate and abandons filtering residue.

In the described steps d, distillation, concentrating appts can be installed, contain a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and be condensed into particulate matter or paste object.

Among the described step e, surplus stock can be put into 10 times of amount ethanol, heating and refluxing extraction 2 times each 1～2 hour, leaves standstill 2 extracting solution merging; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged 1.36 o'clock filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol; gained filtrate is adjusted proportion to 1.06, and the extractum that reduces pressure to get is put into dehydrator and is dried; then add dextrin and be in harmonious proportion, put into granulator and make 1-2 centimetre of granule.

Among the described step f, can mix with making granule or powder in the step 9 molding of pack packing with the Folium Ginkgo extract that above-mentioned steps makes.

Decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is fried, and not exclusively mouthfeel is poor, is not suitable for the Modern human populations medication custom.Because this aspect is mainly used in preventing and treating hyperlipemia, hyperglycemia, this disease belong to multifactor relevant chronic disease, and the course of disease is longer, need long-term prescription just can reach good effect, so should select to take, carry, health product easy to use.The characteristics such as health product have the bad smell of covering, and are attractive in appearance, as to be easy to swallow, and technique is simple, and onset is rapid, is fit to long-term taking, can not damage health.The invention solves the virose shortcoming of Folium Ginkgo; And the beneficiating ingredient that has kept greatly Folium Ginkgo makes it not have work in-process to run off, and has on the make avoided secondary pollution, is the health product of green health environmental protection fully.Add some blood circulation promoting and blood stasis dispelling, blood sugar lowering and Triglycerides in Serum all have the Chinese crude drug of obvious effect, can improve microcirculation, improve immunity.And the most mouthfeel of these medical materials is light, makes the people be easy to accept, and more can reach preferably the effect of blood fat-reducing blood pressure-decreasing.

The specific embodiment

The Mineral Concentrations such as VC, VE, carotene and calcium, phosphorus, boron, selenium are also very abundant in the Folium Ginkgo, surpass general fruit and vegetable and edible plant raw material.Biological anti-oxidant is a class material that directly and indirectly has anti-oxidation function in the body.In Folium Ginkgo, contain two class antioxidants--nutrient antioxidant and non-nutritive antioxidant.The former mainly contains carotene, VC, VE, selenium, zinc, copper etc.; the latter mainly contains ginkgetin, terpene lactones, catechin, Polyphenols etc.; content is also very abundant, and they are not subjected to have ten important effects aspect the oxidative damage due to the free radical at the protection body.Therefore, Folium Ginkgo integrates nutrition, health care, treatment function, and Folium Ginkgo is developed as the resource that high nutrition, health care are worth, and this is significant for improving the Folium Ginkgo comprehensive utilization ratio.The development and use of Folium Ginkgo are from the thirties in 20th century, and Japan and West Germany have namely begun the research of Folium Ginkgo.Along with deepening continuously of modern pharmacological research, to find not only to contain Flavonoid substances in the Folium Ginkgo, and also have the chemical compounds such as terpene lactones, phenols, the pharmacological action of their brilliances is familiar with gradually by people.Clinical observation proves that Folium Ginkgo has following several effect: 1, reduce cholesterol levels in the blood of human body, prevent arteriosclerosis.To be short of physical strength behind the middle-aged and elderly people light activity, palpitating speed, chest pain, the effect of being significantly improved such as feel dizzy.2, reduce blood pressure by increasing the saturating property of blood vessel and elasticity, preferably antihypertensive effect is arranged.3, the deposition composition on the elimination blood vessel wall improves blood flow and changes, and promotes erythrocyte deformability, and blood viscosity lowering makes blood flow unobstructed, can prevent and treat cerebral hemorrhage and cerebral infarction.The senile dementia that arteriosclerosis is caused also has certain curative effect.Gingko leaf preparation and antidiabetic drug share the treatment diabetes good therapeutic effect, can be used for the adjuvant of diabetes.5, can obviously alleviate the symptoms such as abdominal pain in menstruation and sore waist and aching in the waist and the back.6, be used for the treatment of bronchial asthma, good therapeutic effect is also arranged.7, reduce level of lipid, reduce freckle, moist skin, beautiful appearance.8, relieving constipation, diuresis, toxin expelling, detoxifcation.9, climacteric syndrome is improved significantly.

Folium Ginkgo has the formation that suppresses fatty liver, the effect that reduces serum fat and inhibition atherogenesis.Active component comprises DNJ, plant sterol, flavonoid etc.Contain the flavones ingredient of strengthening blood capillary, reducing blood viscosity in the Folium Ginkgo, the Folium Mori product contain the composition of LDL-lipoprotein oxidation in the antibody in addition, so Folium Ginkgo has again the effect of prevention myocardial infarction and cerebral hemorrhage when fat-reducing, improving hyperlipemia.The hyperlipemia serum lipids is raise Folium Ginkgo extract and atherosclerosis has inhibitory action.Find that after deliberation the Folium Ginkgo product can make hyperlipidemia rats serum high-density LP (HDL-C), HDL-CTC obviously raise (p＜0.05), T-CHOL (TC), LDL-C, triacylglycerol (TG) obviously reduce (p＜0.05), lipid peroxide (LPO) significantly reduces (p＜0.001), but Folium Ginkgo blood fat reducing, vessel softening, removing body endoperoxide are described, thereby the rising of hyperlipemia serum lipids and atherosclerosis are had inhibitory action.But anemia of pregnant woman of the present invention and child, old man are careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, the old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting the blood coagulation situation, not the blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel more can not long-term taking, in order to avoid cause cerebral hemorrhage.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.

Fructus Rubi is warm in nature; Sweet, sour; Return kidney, urinary bladder channel.Cure mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Be used for enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea." Bencao Jingshu ": " Fructus Rubi, its main QI invigorating person says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, and then body is sent out not in vain not also from light.The respectful main tonify deficiency of reviving is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.Zhen Quan master man kidney-jing deficiency exhausts, impotence, woman's food son arranged.Large bright main settling five organs, beneficial color is supported vital essence, long hair, strong will.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence." " property of medicine opinion " carry its: " main man's kidney-jing deficiency exhausts, woman's food son arranged.Main impotence."

Fructus Corni cures mainly pathogen cold and heat under the heart, and warming middle-JIAO by cold warm numbness, goes three worms, for a long time made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, the merit of dribbling urination only of clothes; For a long time clothes make eye bright, brute force all the year round.Fructus Corni has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is China's rare Chinese medicine commonly used, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties usefulness that medical science is liked.Zhang Zhongjing has been formulated " JINGUI SHENQI WAN " take Fructus Corni as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibiotic, is the Herba indigoferae Pseudotinctoriae of commonly using in the tcm clinical practice.

Radix Et Rhizoma Fagopyri Tatarici is the very few medicine-food two-purpose crop of occurring in nature, puts down in writing according to Compendium of Material Medica: the Radix Et Rhizoma Fagopyri Tatarici bitter in the mouth, and property is flat cold, the real the intestines and stomach of energy, physical strength profiting, continuous spirit, sharp knowledge, refining the five internal organs slag is dirty; All on the books to Radix Et Rhizoma Fagopyri Tatarici in Thousand Golden Prescriptions, " Chinese medicine voluminous dictionary " and pertinent literature: can calm the nerves, the swollen wind pain of lively atmosphere blood, the wide intestinal of sending down the abnormal ascending QI, heat clearing away, long-pendingization of dispelling are stagnant, bowel relieving, intestine moistening, relieving constipation, cough-relieving, relieving asthma, the effects such as antiinflammatory, antiallergic, heart tonifying, fat-reducing, beauty treatment.Radix Et Rhizoma Fagopyri Tatarici--seven major nutrient complete set is not medicine, is not health product, is to work as the food that meal is eaten, and remarkable healthy nutritive value and outstanding dietetic therapy effect are but arranged.It does not belong to grass family, and belongs to Polygonaceae, and " Radix Polygoni Multiflori, the Radix Et Rhizoma Rhei " be familiar with people etc. is the blood brother, is the outstanding grain medicine dual-purpose grain kind that international food and agricultural organization generally acknowledges, is typical case's embodiment of China's integration of edible and medicinal herbs culture.Radix Et Rhizoma Fagopyri Tatarici is described as " kings of grain rice ", and three fall food (blood pressure lowering, blood sugar lowering, blood fat reducing).Produce in high and cold mountain area, Southwest China and Shanxi north one band, green natural, pure nothing is dyed, and because of place of production difference nutritive value difference.Radix Et Rhizoma Fagopyri Tatarici have uniqueness, comprehensively, abundant nutrition, and medicinal characteristic is good, and the necessary multiple nutrients composition of human body is arranged, so be described as human " natural gold partner " by world's nutritionist.Radix Et Rhizoma Fagopyri Tatarici can anti-inflammation, and the laudatory title of " antiinflammatory grain " is arranged.

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to usefulness, controls early whitening of beard and hair, often joins the same usefulness of Fructus Mori, and Cortex Lycii is often joined in fever due to yin deficiency.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, hepatic injury to Carbon Tetrachloride Induced has obvious protective effect, and can promote liver cell regeneration. and oleanolic acid also can make in the liver triglyceride accumulate that minimizings, hepatocellular degeneration necrosis obviously alleviate, glycogen is accumulated increase, serum γglobulin decline; Mitochondrial swelling and the degeneration of endoplasmic reticulum vesicle alleviates, the matter inflammatory reaction weakens between hepatic tissue in the visible hepatocyte of ultrastructure.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Fructus Gardeniae is the fruit of Fructus Gardeniae tree, is Chinese medicine.The l that belongs to the Ministry of Public Health promulgation criticizes the medicine-food two-purpose resource, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in treating the diseases such as icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.It is vexed to cure mainly calentura; The liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; The dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly the three warmers pathogenic heat, but the conjunctival congestion and swelling pain that the treating the liver gallbladder is attacked on burning hot is often joined Radix Et Rhizoma Rhei usefulness, such as Fructus Gardeniae soup " Shengji Zonglu ".

Radix Codonopsis is China's traditional tonic commonly used, and the Radix Codonopsis that produce take area, Shangdang, Shanxi ancient times has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting as top grade.Modern study, Radix Codonopsis contain various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, have enhancing immunity, blood vessel dilating, blood pressure lowering, improve microcirculation, strengthen the effects such as hemopoietic function.The leukopenia that in addition chemotherapy radiotherapy is caused has castering action.Radix Codonopsis has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc." Bencao Congxin " record: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than the middle feeble QI, mend in order to transfer, very smooth and proper.”

Herb Gynostemmae Pentaphylli is found through modern medicine study, the main effective ingredient of Herb Gynostemmae Pentaphylli is polysaccharide, flavonoid, saponins and microelement kind, its effect mainly is to promote body fat class substance metabolism, nutrition human body cell, have simultaneously good detoxicating, relieving inflammation effect, be widely used in treatment and the health care of hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, chronic respiratory inflammation (pharyngolaryngitis, gastroenteritis etc.).

Poria sweet in the mouth, light, property are flat, be used as medicine have promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.The Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.Has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, the edema distension, the phlegm retention cough with dyspnea, vomiting, malignant histocytosis is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria reaches by strong activating the spleen pulmonary function, and is different from the Chinese medicine of other direct diuretic.Be used for diarrhea due to hypofunction of the spleen, the leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, for have loose bowels due to the insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, use the effect that Poria has giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as the tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

The Herba Eupatorii expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience heat-damp in summer; The cold and heat headache; Accumulate in moistening; The gastral cavity painful abdominal mass is not hungry; Nausea and vomiting; Sweet greasy in mouthful; Disappear truly. " Bencao Jingshu ": lung governing qi, lung qi pent-up, then upper orifices is closed and lower orifices are obstructed, stomach master Na Shuigu, stagnation of stomach-QI, then water paddy not take the time and as accumulation of phlegm in the hypochondrium, Herba Chlorophyti is hot flat eliminating stagnation to stagnate, fragrance can be disliked by dirt eliminating, then come up all cards from recover, mostly appetizing removes and dislikes, the lung heat clearing expectorant, and the panacea of Disperse hepatic depression is also." key medicine is divided agent ": Herba Chlorophyti, be the product of expectorant except the Yu Xiejie that dislikes, falls apart, " interior warp " treating with Herba EuPatorii of quenching one's thirst, removing the accumulation of stale pathogen is also.Lid is quenched one's thirst by pathogenic heat pent-up in stomach, blue can removing the accumulation of stale pathogen.Herba Chlorophyti is solid to cleanse as merit as can be known, and elimination the intestines and stomach person also.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Remarkable inhibitory action is also arranged." property of medicine opinion " carries it: monarch, and sweet in the mouth, suffering, nontoxic.Can main large migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, sputum is removed in appetizing, except cold and heat, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and the insufficiency of stomach-QI cold-dysentery.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, the lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.The Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.

Rhizoma Alismatis (rhizome) is one of traditional Chinese medicine.Theory of Chinese medical science thinks that it is cold in nature, has the effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slow down atherogenesis; Rhizoma Alismatis and preparation modern times thereof also are used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.The fat-soluble part of Rhizoma Alismatis has obvious cholesterol reducing effect and study of anti-atherogenic effect to the experimental hypercholesterolemicrabbits rabbit, by wherein separate Alisol A, B and Alisol A, the acetas of B, C, except alisol B, aobvious cholesterol reducing effect is arranged.Content with 0.1% adds in the feedstuff of experimental atherosclerosis rats, and cholesterolemia is descended more than 50%, and is wherein the strongest with Alisol A-24-acetas effect.The ethanol extraction of Rhizoma Alismatis, the ethyl acetate extract of ethanol extract etc. have effect for reducing blood fat to experimental hypercholesterolemicrabbits rabbit and rat.Ethyl acetate extract and its residual fraction effect that is insoluble in acetic acid one water are the strongest.Ethyl acetate extract oral 1g/kg every day also has obvious cholesterol reducing effect to the normal rat of raising with normal diet.Prove that with coordination list notation method Alisol A has the ability that suppresses the mouse small intestine esterified cholesterol, and can make the absorbance of cholesterol in rat small intestine reduce by 34%, but do not affect linoleic absorption.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The medicinal so far history in existing more than 2000 year of the Radix Astragali, modern study, the Radix Astragali contain the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.The enhancing human body immunity function arranged, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But the table excess pathogen is contained, retention of dampness due to stagnation of QI, food stagnation is stagnated, carbuncle from the beginning of or burst after the excess syndrome such as pyretic toxicity Shang Sheng.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " record: " main carbuncle loses skin ulcer for a long time, the evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help the gas strengthening bone and muscle, put on flesh and enrich blood.”

Propolis (bee glue) have the good reputation of " blood vessel street cleaner ", what the recent domestic scholar did studies show that in a large number, flavonoid in the propolis (flavonoid) composition and various active composition, can improve elasticity and the permeability of blood vessel, vasodilator is removed the overstocked thing of depositing of blood vessel, purify the blood, blood fat reducing, blood viscosity lowering improves and organizes microcirculating state, and the effect that has stronger antioxidation, removes free radical.The toxicological experiment result shows that propolis is actual innocuous substance, is safe and feasible by the prevention of long-term taking propolis and treatment hyperlipemia therefore.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, really the gas medicine in the blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain relieving constipation of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

The Flos Carthami promoting blood circulation to restore menstrual flow, the blood stasis removing pain relieving.The promoting blood circulation to restore menstrual flow medicine.Flos Carthami decoct, Carthamus yellow and other preparations all have in various degree rapid depressurization effect to anesthetized cat or dog, and mean blood pressure descends about 20 mm Hg, continues to recover after about 30 minutes.. " book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood is also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters the blood chamber, and delirium is gone mad; Or blood is vexed interior swollen, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.All friendship such as the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred.

Heterophyllum is planted latin name: Dracocephalum heterophyllum Benth.All herbal medicine.Cure mainly clearing away lung-heat to relieve cough, promoting the function of the gallbladder to alleviate jaundice, cool liver endogenous wind stopping, hard masses softening and resolving.Control hypertension, lymphadenitis, cough due to lung-heat.Good depressor.

Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, have the YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, the disease such as pass out semen, quench one's thirst, is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.This quality is moistened into kidney, kind nourishing kidney yin, and life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five ZANG-organs is Kidney-Yin ", " mending greatly true water ".Normal be equal to usefulness with Rhizoma Dioscoreae, Fructus Corni, treat the hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst etc., but invigorating the liver and kidney, beneficial marrow is such as LIUWEI DIHUANG WAN.

Specific embodiment 1:

Preparation: get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 9h (it is fixed that the time is looked the sample moisture, can 8～12h), and take out and place cooling in the drying baker, pulverized 60 mesh sieves with pulverizer, powder places brown wide mouthed bottle to store.

Lixiviate: prepare 60% alcoholic solution (get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution).Get the 100g ginkgo leaf powder in 700mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 700mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.

Sucking filtration: use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing.

Distillation, concentrated: distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.A certain amount of ethanol also has bactericidal action, when measuring the extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, and ethanol is volatilized totally fully.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.Can take simple method, direct heating in water bath, the ethanol that in air, volatilizees, this method shortcoming: can not Recycled ethanol.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.

Dry: owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, and utilization increases vacuum and reduces boiling point, removes last ethanol and residual part moisture.If conditions permit can also adopt freezing and drying lyophilization dry.Except containing flavonoid and lactone, also contain a certain amount of impurity in the extract of this moment.

All the other raw materials are granulated: with all the other raw material Fructus Rubies, and Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Fructus Corni, Radix Salviae Miltiorrhizae, Poria, heterophyllum, Radix Codonopsis, Herba Eupatorii, Herb Gynostemmae Pentaphylli, the Radix Astragali, Rhizoma Alismatis, Flos Carthami, Radix Scutellariae, the Radix Paeoniae Alba, Fructus Gardeniae, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Radix Et Rhizoma Fagopyri Tatarici, the agent of propolis granulation.

Packing: with the above-mentioned granule that makes, the Folium Ginkgo extract good with aforementioned dry in the sun mixes, and then can pack product, can be distributed into the essay bag of 10-15 gram, also can integral body be mixed into the bag sale.

Specific embodiment 2:

Pluck the fresh and tender Folium Ginkgo of 2500g, clean, dry, in 70 ℃ of baking ovens, baking 9h takes out and places cooling in the drying baker, pulverizes 60 mesh sieves with pulverizer, powder places brown wide mouthed bottle storage preparation 60% alcoholic solution (get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution).Get the 1000g ginkgo leaf powder in 7000mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 7000mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.Use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing.Distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.A certain amount of ethanol also has bactericidal action, when measuring the extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, and ethanol is volatilized totally fully.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.Can take simple method, direct heating in water bath, the ethanol that in air, volatilizees, this method shortcoming: can not Recycled ethanol.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.Owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilizes increase vacuum to reduce boiling point, removes last ethanol and residual part moisture.If conditions permit can also adopt freezing and drying lyophilization dry.With all the other raw material Fructus Rubi 500g, Radix Rehmanniae Preparata 500g, Radix Angelicae Sinensis 500g, Fructus Corni 500g, Radix Salviae Miltiorrhizae 500g, Poria 500g, heterophyllum 500g, Radix Codonopsis 500g, Herba Eupatorii 500g, Herb Gynostemmae Pentaphylli 500g, Radix Astragali 500g, Rhizoma Alismatis 500g, Flos Carthami 500g, Radix Scutellariae 500g, Radix Paeoniae Alba 500g, Fructus Gardeniae 500g, Rhizoma Atractylodis Macrocephalae 500g, Fructus Ligustri Lucidi 500g, Radix Et Rhizoma Fagopyri Tatarici 500g, propolis 500g put it in 10 times of amount ethanol, heating and refluxing extraction 2 times each 1～2 hour, leaves standstill 2 extracting solution merging; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged; the concentrating under reduced pressure relative density is the filtrate of 1.36 (80 ℃); Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, and extractum reduces pressure to get; putting into dehydrator dries; add dextrin, put into granulator and make 1-2 centimetre of granule, then fully mix with the Folium Ginkgo product extract finished product that above-mentioned steps obtains; be distributed into the essay bag of 10-15 gram, also can integral body be mixed into the bag sale.Can be distributed into the essay bag of 10-15 gram, also can integral body be mixed into the bag sale.

Specific embodiment 3:

Pluck the 1200g Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 9h takes out and places cooling in the drying baker, pulverized 60 mesh sieves with pulverizer, powder places brown wide mouthed bottle storage preparation 60% alcoholic solution (get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution).Get the 500g ginkgo leaf powder in 3500mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 35000mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.Use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing.Distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.Owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilizes increase vacuum to reduce boiling point, removes last ethanol and residual part moisture.With all the other raw material Fructus Rubi 230g, Radix Rehmanniae Preparata 240g, Radix Angelicae Sinensis 230g, Fructus Corni 250g, Radix Salviae Miltiorrhizae 240g, Poria 250g, heterophyllum 240g, Radix Codonopsis 250g, Herba Eupatorii 240g, Herb Gynostemmae Pentaphylli 250g, Radix Astragali 240g, Rhizoma Alismatis 230g, Flos Carthami 250g, Radix Scutellariae 230g, Radix Paeoniae Alba 250g, Fructus Gardeniae 240g, Rhizoma Atractylodis Macrocephalae 220g, Fructus Ligustri Lucidi 230g, Radix Et Rhizoma Fagopyri Tatarici 220g, propolis 250g put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, add 8-10 times of water gaging for the first time and decocted 1-2 hour, add 4-8 times of water gaging for the second time and decocted 1-2 hour, merge decocting liquid twice, filter to get filtrate; Heating is concentrated into pasty state, cools off after putting into 80 ℃ of oven dry of baking oven, is ground into fine powder.Then fully mix with the Folium Ginkgo extract that above-mentioned steps obtains, be distributed into the essay bag of 10-15 gram, also can integral body be mixed into the bag sale.Can be distributed into the essay bag of 10-15 gram, also can integral body be mixed into the bag sale.

Decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is fried, and not exclusively mouthfeel is poor, is not suitable for the Modern human populations medication custom.Because this aspect is mainly used in preventing and treating hyperlipemia, hyperglycemia, this disease belong to multifactor relevant chronic disease, and the course of disease is longer, need long-term prescription just can reach good effect, so should select to take, carry, health product easy to use.The characteristics such as health product have the bad smell of covering, and are attractive in appearance, as to be easy to swallow, and technique is simple, and onset is rapid, is fit to long-term taking, can not damage health.

Pharmacology's toxicity test

Health product acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: health product of the present invention contain 0.0365g crude drug/g.

Two, method:

1, LD50 calculates: adopt the improvement karber's method, mice is divided into 5 groups at random, 10 every group, male and female half and half with adding distil water dissolving of the present invention, are made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18,14.4 to dosage by the crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, at twice administration in one day (interval half an hour), each 0.5ml observes the animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.With adding distil water of the present invention dissolving, be made into maximum concentration, by the maximum tolerated dose of animal, fill with injection and to feed device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, at twice feedwater (interval half an hour) in a day, each 0.5ml (every ml contains crude drug 0.036g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation is 7 days after the administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, there are no death.Namely select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD＞18g/Kg.d.

Long term toxicity test data of the present invention

Chinese medicine of the present invention is through 6 months long-term toxicity test for animals result of gastric infusion: the SD rat is divided into three groups, 30 every group, male and female half and half (being divided into high, medium and low three dosage groups, 10 every group), wherein first group through gavage to normal saline; Second group is given dosage of the present invention through gavage is 0.25g, 2.5g and 12.5g/kg.d; The 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of lovastatin.During administration, observe respectively that clinical manifestation, hematology, blood after each treated animal administration is biochemical, the indexs such as organ coefficient and histopathology carry out the evaluation of drug toxicity.Result of study: main toxic reaction shows lovastatin 50mg/kg.d and 5.0mg group, shows after the administration that reaction and the symptoms such as sialorrhea, hair are fluffy, busy, diarrhoea, step have appearred in the SD rat, total food ration with lose weight; Blood test shows that total white blood cells increases to some extent, erythrocyte sum, content of hemoglobin and platelet count obviously descend (P all＜0.05); Blood biochemistry checking shows that ALT, AST, ALP and CK raise 1～8 times (P all＜0.05), and creatinine and blood urea nitrogen raise (P all＜0.05) to some extent, but do not cause animal dead; Histopathological analysis result shows that the Liver and kidney pathological change similar to the people appearred in lovastatin 50mg/kg.d group.And similar reaction does not all appear in three dosage groups of normal saline group and 0.25g of the present invention, 2.5g and 12.5g/kg.d and lovastatin 0.5mg/kg.d dosage group during whole administration, at the convalescent period viewing duration, the symptom that each treated animal of reaction the occurs recovery normal condition that fades away.As seen the present invention not only can reduce the toxic and side effects of lovastatin, and can make the clinical non-toxic of lovastatin increase to 5～25 times (P all＜0.01).

The specific embodiment:

At present, the blood fat-reducing blood pressure-decreasing product is all very fiery both at home and abroad, and traditional Chinese medicine capable of reducing weight blood fat-reducing blood pressure-decreasing health product also is a dark horse, sweep the country. but the research of health product blood fat-reducing blood pressure-decreasing effect, be main mainly with clinical observation on the therapeutic effect greatly, the animal experiment study that less employing is tight, so that science is not strong, cogency is not enough.The present invention comes verification the verifying results with zoopery.

1 materials and methods

1.1 material

1.1.1 laboratory animal: 80 of ICR mices, public 40, female 40, body weight 18-22g, Shandong Medical University's laboratory animal

The center provides.

1.1.2 tested material: blood fat-reducing blood pressure-decreasing Semen Ginkgo product of the present invention, give health product granule of the present invention for tested group 1, give pasty state medicated powder of the present invention (among the present invention medicinal boiling water soak make pasty state for subsequent use) for tested group 2, give ginkgo Leaves health care product powder of the present invention for tested group 3.

1.2 experimental technique

1.2.1 Weight-reducing and lipid-lowering experimental technique

Get 40 mices, be divided at random 4 groups, 10 every group, tested group 1,2,3 gives respectively different tested materials, gives tested material every day once; Matched group is not done special handling, and each group is all fed with high lipid food, and is quantity-unlimiting, and feed continuously 15d. and weigh subsequently, separation of serum, and survey serum triglycerides and T-CHOL with GPO-PAP method and CHOD-PAP method respectively; Dissect mice, isolate mouse testis place fatty tissue and weigh, the body weight between comparable group, fat weight, T-CHOL and triglyceride carry out the t check.

1.2.2 the microcirculation experimental technique is got 40 mices, is divided at random 4 groups, 10 every group (male and female half and half), the every Mus auris dextra of matched group be coated with normal saline a little; The every Mus auris dextra of positive group is trained first HUOXUE ZHITONG GAO, give respectively different tested materials for tested group 1,2,3, the 15min pneumoretroperitoneum is injected 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein injection 0.1% epinephrine 0.1mL/10g observes immediately mouse right ear fine motion vein bore (Lm) and 0.2mm2 blood capillary net number .t check and processes experimental data subsequently.

2 results and discussion

2.1 interpretation of result

2.1.1 the impact on Mouse Weight, fat weight is compared with matched group, tested group 1 on the impact of Mouse Weight, fat weight little (P〉0.05); Tested group of 2 pairs of Mouse Weights, fat weights have remarkable reducing effect (P＜0.01); Tested group of 3 pairs of Mouse Weights, fat weight also have obvious reducing effect (P＜0.05, P＜0.01).

Table 1 Folium Ginkgo, Chinese medicinal granule and the present invention are on the impact of Mouse Weight, fat weight

2.1.2 the impact on mice serum triglyceride, T-CHOL is compared with matched group, tested each group is to the reducing effect of mice serum T-CHOL not obvious (P〉0.05), but serum triglycerides all there is remarkable reducing effect (P＜0.01), illustrates that tested medicinal liquid, granule, medicated powder and the two are combined with serum triglycerides is had reducing effect (table 2).

Table 2 the present invention is on the impact of mice serum triglyceride, T-CHOL

2.2 discuss

2.2.1 regulating the main testing index a. of blood fat T-CHOL measures; B. triglyceride determination.

2.2.2 improving microcirculation Weight-reducing health articles for use multipotency plays a role by improving microcirculation. microcirculation mainly is viviperception, look-out station commonly used is bulbar Conjunctiva Microcirculation, auricular microcirculation etc., and observation index is microvascular diameter, blood capillary site counting, blood capillary blood flow velocity, fluidised form, color, blood capillary variation on every side etc.Reduce blood pressure by increasing the saturating property of blood vessel and elasticity, preferably antihypertensive effect is arranged.

Experimental result shows that the present invention all has obvious reducing effect to Mouse Weight, fat and serum triglycerides, and reduces blood pressure by increasing the saturating property of blood vessel and elasticity, and preferably antihypertensive effect is arranged; And can improve microcirculation, blood pressure lowering blood fat reducing hypoglycemic activity has been described.

But anemia of pregnant woman of the present invention and child, old man are careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, the old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting the blood coagulation situation, not the blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel more can not long-term taking, in order to avoid cause cerebral hemorrhage.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.

Claims (10)

1. Folium Ginkgo blood fat-reducing blood pressure-decreasing health product is characterized in that, the parts by weight of various raw materials are in the described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product: 50～100 parts of Folium Ginkgos, 10～20 parts of Fructus Rubies, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Poria, 10～20 parts of heterophyllum, 10～20 parts of Radix Codonopsis, 10～20 parts of Herba Eupatoriis, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Alismatis, 10～20 parts on Flos Carthami, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Gardeniaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of propolis.

2. described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 1 is characterized in that the parts by weight of various raw materials are in the described health product: 50～85 parts of Folium Ginkgos, 10～15 parts of Fructus Rubies, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Corni, 10～150 parts of Radix Salviae Miltiorrhizaes, 10～15 parts in Poria, 10～15 parts of heterophyllum, 10～15 parts of Radix Codonopsis, 10～15 parts of Herba Eupatoriis, 10～15 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Alismatis, 10～20 parts on Flos Carthami, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Gardeniaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of propolis.

3. described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 1 is characterized in that the parts by weight of various raw materials are in the described health product: 50～100 parts of Folium Ginkgos, 10～20 parts of Fructus Rubies, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Poria, 10～20 parts of heterophyllum, 10～20 parts of Radix Codonopsis, 10～20 parts of Herba Eupatoriis, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Alismatis, 10～15 parts on Flos Carthami, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Gardeniaes, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～15 parts of propolis.

4. preparation method such as claim 1～3 Folium Ginkgo blood fat-reducing blood pressure-decreasing health product as described in each is characterized in that the preparation process of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product is:

A. the Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into particulate matter, powder or unguentum;

E. with the agent of surplus stock granulation, powder or unguentum;

F. granule obtained above, powder or unguentum are fully mixed rear pack with the Folium Ginkgo extract of making.

5. the preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4, it is characterized in that: among the described step a, get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 8-12h, taking-up places cooling in the drying baker, pulverizes 60 mesh sieves with pulverizer, and powder places brown wide mouthed bottle to store.

6. the preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4, it is characterized in that: among the described step b, get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution; Then get the 100g ginkgo leaf powder in 700mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 700mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.

7. the preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4 is characterized in that: among the described step c, ginkgo biloba succi is used first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed; The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, after the sucking filtration end, gets filtrate and abandons filtering residue.

8. the preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4 is characterized in that: in the described steps d, distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and be condensed into particulate matter or paste object.

9. the preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4 is characterized in that: among the described step e, the surplus stock component is put into 10 times of amount ethanol, heating and refluxing extraction 2 times each 1～2 hour, merges 2 extracting solution and leaves standstill; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged 1.36 o'clock filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol; gained filtrate is adjusted proportion to 1.06, and the extractum that reduces pressure to get is put into dehydrator and is dried; then add dextrin and be in harmonious proportion, put into granulator and make 1-2 centimetre of granule.

10. the preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4 is characterized in that: among the described step f, fully mix the molding of pack packing with the Folium Ginkgo extract that above-mentioned steps makes with making granule or powder among the step e.