CN103536690B - Traditional Chinese medicine oral liquid for reducing blood pressure - Google Patents
Traditional Chinese medicine oral liquid for reducing blood pressure Download PDFInfo
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- CN103536690B CN103536690B CN201310463394.XA CN201310463394A CN103536690B CN 103536690 B CN103536690 B CN 103536690B CN 201310463394 A CN201310463394 A CN 201310463394A CN 103536690 B CN103536690 B CN 103536690B
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Abstract
The invention discloses traditional Chinese medicine oral liquid for reducing the blood pressure, which is prepared from the following raw materials in parts by weight: 20-25 parts of radix astragali, 15-20 parts of fructus corni, 15-20 parts of semen plantaginis, 10-15 parts of fructus gardeniae, 10-15 parts of folium ginkgo, 10-15 parts of fructus schisandrae chinensis, 10-15 parts of fructus rubi, 10-15 parts of rhizoma atractylodis macrocephalae, 10-15 parts of fructus crataegi, 5-10 parts of radix codonopsis, 5-10 parts of flos sophorae, 5-10 parts of herba cistanche, 5-10 parts of radix angelicae pubescentis and 5-10 parts of angelica sinensis. The traditional Chinese medicine oral liquid disclosed by the invention is mainly used for calming the liver and suppressing yang and removing stasis and activating blood while taking care of the heart, liver, spleen and kidney and strengthening the spleen and clearing damp, and clinically realizes a perfect curative effect on the hypertensives.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine, particularly relate to a kind of Chinese medicine oral liquid of blood pressure lowering.
Background technology
Hypertension is a kind of global common chronic disease, and be also the topmost risk factor of cardiovascular and cerebrovascular disease, apoplexy, myocardial infarction, heart failure and chronic kidney disease are its major complications, are the principal diseases of harm humans health.Hypertension rate increases with the age and raises; Women's prevalence before climacteric, a little less than male, but to raise rapidly, even higher than male after climacteric; High latitude cold district prevalence is higher than the warm area of low latitudes, and high altitude localities is higher than low altitude area; Relevant with dietary habit, salt and saturated fat are taken in higher, and mean blood pressure level and prevalence are also higher.Population of China hypertension is popular has two to compare outstanding feature: from south to the north, Prevalence of Hypertension is increasing trend.Reduce the blood pressure level of hyperpietic, can obviously reduce apoplexy and the events of heart attack, significantly improve the life quality of patient, effectively reduce Disease Spectrum.
The antihypertensive Western medicine kind of current Clinical practice is more, but generally needs multi-medicament drug combination just can reach good blood pressure lowering effect, and still has some patients to conventional depressor unsatisfactory curative effect, or can not apply because of its side effect.And also have the Chinese Traditional Medicines of a lot of blood pressure lowering on the market, but curative effect is unsatisfactory, can only play the effect of auxiliary western medicine when treating.
Summary of the invention
The object of the invention is to for above-mentioned technical problem, a kind of Chinese medicine oral liquid of evident in efficacy, blood pressure lowering that single drug is effective is provided.
For achieving the above object, the technical solution adopted in the present invention is: a kind of Chinese medicine oral liquid of blood pressure lowering, is made up of the crude drug of following weight portion: Radix Astragali 20-25 part, Fructus Corni 15-20 part, Semen Plantaginis 15-20 part, Fructus Gardeniae 10-15 part, Folium Ginkgo 10-15 part, Fructus Schisandrae Chinensis 10-15 part, Fructus Rubi 10-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Fructus Crataegi 10-15 part, Radix Codonopsis 5-10 part, Flos Sophorae 5-10 part, Herba Cistanches 5-10 part, Radix Angelicae Pubescentis 5-10 part, Radix Angelicae Sinensis 5-10 part.
Preferably: the Radix Astragali 23 parts, Fructus Corni 17 parts, Semen Plantaginis 17 parts, Fructus Gardeniae 12 parts, Folium Ginkgo 12 parts, Fructus Schisandrae Chinensis 12 parts, Fructus Rubi 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Crataegi 12 parts, Radix Codonopsis 7 parts, 7 parts, Flos Sophorae, Herba Cistanches 7 parts, Radix Angelicae Pubescentis 7 parts, Radix Angelicae Sinensis 7 parts.
The Chinese medicine oral liquid of blood pressure lowering of the present invention is made up of following methods:
(1) take the mixing of each crude drug by weight, add the distilled water immersion of 10 times of weight after 5 hours, decoct twice, first time decocts 30 minutes, and second time decocts 25 minutes;
(2) collecting decoction, filters, is evaporated to every milliliter of decocting liquid and is equivalent to 1 gram of crude drug;
(3) in decocting liquid, add appropriate xylitol, sterilizing, subpackage, obtain oral liquid of the present invention.
The meridian distribution of property and flavor of above-mentioned medical material is as follows:
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Can benefiting QI for strengthening the superficies, arresting sweating admittedly de-, holder skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Fructus Corni: sour, puckery, tepor.Return liver, kidney channel.Can liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating, controlling nocturnal emission with astringent drugs reducing urination, leukorrhagia stopping only collapses, hidroschesis, also has promoting the production of body fluid to quench thirst in addition.For soreness of waist and knee joint, dizziness and tinnitus, forgetful emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, menoxenia, profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Semen Plantaginis: sweet; Light; Cold nature.Return lung meridian; Liver Channel; Kidney channel; Urinary bladder channel.Clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.Cure mainly: main dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily.
Fructus Gardeniae: bitter, cold, nontoxic.GUIXIN warp; Liver Channel; Lung meridian; Stomach warp; Tri-jiao channel.Can pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.
Folium Ginkgo: mildly bitter flavor, property is put down.There is the beneficial heart, promoting blood circulation and stopping pain, astringe the lung relieving asthma, effect of removing dampness antidiarrheal.
Fructus Schisandrae Chinensis: temperature; Sour, sweet; Return lung, the heart, kidney channel.Can restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Fructus Rubi: sweet acid, flat.Return liver; Kidney channel.Can the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Air making-up and spleen enlivening, dampness diuretic, hidroschesis, antiabortive.
Fructus Crataegi: appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.
Radix Codonopsis: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Middle QI invigorating, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Flos Sophorae: bitter in the mouth; Cold nature.Return liver; Lung; The heart; Large intestine channel.Cooling blood for hemostasis; Liver heat removing and eyesight improving.Main discharging fresh blood stool; Hemorrhoid hematochezia; Dysentery; Hematuria; Stranguria with blood; Metrorrhagia; Spit blood; Epistaxis; Liver-heat is had a headache; Conjunctival congestion and swelling pain; Carbuncle skin infection.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, has a headache dizzy.
Herba Cistanches: sweet in the mouth, salty, warm in nature.Energy kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.
Radix Angelicae Pubescentis: pungent, bitter, tepor.Return liver, kidney, urinary bladder channel.For wind prevailing over dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.
Radix Angelicae Sinensis: sweet in the mouth; Pungent; Bitter; Warm in nature.Return liver; The heart; Spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.
The Chinese medicine oral liquid of a kind of blood pressure lowering provided by the present invention, based on suppressing the hyperactive liver and subsiding YANG, promoting blood circulation by removing blood stasis, takes into account the heart, liver,spleen,kidney, invigorating the spleen to clear away damp pathogen, has good curative effect clinically to hyperpietic.
Embodiment
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.When not deviating from the present invention's spirit and essence, the amendment do the inventive method, step or condition or replacement, all belong to scope of the present invention.
Embodiment 1
Take following crude drug by weight: the Radix Astragali 20 parts, Fructus Corni 15 parts, Semen Plantaginis 15 parts, Fructus Gardeniae 10 parts, Folium Ginkgo 10 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Rubi 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Crataegi 10 parts, Radix Codonopsis 5 parts, 5 parts, Flos Sophorae, Herba Cistanches 5 parts, Radix Angelicae Pubescentis 5 parts, Radix Angelicae Sinensis 5 parts.
Obtained Chinese medicine oral liquid by the following method:
(1) take the mixing of each crude drug by weight, add the distilled water immersion of 10 times of weight after 5 hours, decoct twice, first time decocts 30 minutes, and second time decocts 25 minutes;
(2) collecting decoction, filters, is evaporated to every milliliter of decocting liquid and is equivalent to 1 gram of crude drug;
(3) in decocting liquid, add appropriate xylitol, sterilizing, subpackage, obtain oral liquid of the present invention.
Embodiment 2
Take following crude drug by weight: the Radix Astragali 25 parts, Fructus Corni 20 parts, Semen Plantaginis 20 parts, Fructus Gardeniae 15 parts, Folium Ginkgo 15 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Rubi 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Crataegi 15 parts, Radix Codonopsis 10 parts, 10 parts, Flos Sophorae, Herba Cistanches 10 parts, Radix Angelicae Pubescentis 10 parts, Radix Angelicae Sinensis 10 parts.
(1) take the mixing of each crude drug by weight, add the distilled water immersion of 10 times of weight after 5 hours, decoct twice, first time decocts 30 minutes, and second time decocts 25 minutes;
(2) collecting decoction, filters, is evaporated to every milliliter of decocting liquid and is equivalent to 1 gram of crude drug;
(3) in decocting liquid, add appropriate xylitol, sterilizing, subpackage, obtain oral liquid of the present invention.
Embodiment 3
Take following crude drug by weight: the Radix Astragali 23 parts, Fructus Corni 17 parts, Semen Plantaginis 17 parts, Fructus Gardeniae 12 parts, Folium Ginkgo 12 parts, Fructus Schisandrae Chinensis 12 parts, Fructus Rubi 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Crataegi 12 parts, Radix Codonopsis 7 parts, 7 parts, Flos Sophorae, Herba Cistanches 7 parts, Radix Angelicae Pubescentis 7 parts, Radix Angelicae Sinensis 7 parts.
(1) take the mixing of each crude drug by weight, add the distilled water immersion of 10 times of weight after 5 hours, decoct twice, first time decocts 30 minutes, and second time decocts 25 minutes;
(2) collecting decoction, filters, is evaporated to every milliliter of decocting liquid and is equivalent to 1 gram of crude drug;
(3) in decocting liquid, add appropriate xylitol, sterilizing, subpackage, obtain oral liquid of the present invention.
Clinical treatment:
Hyperpietic 200 example, wherein man 110 example, female 90 example, age 55-75 year, be divided into embodiment 1 group, embodiment 2 groups, embodiment 3 groups, matched group at random by medical order, often organize each 50 example.
TCM syndrome diagnostic criteria reference Ministry of Public Health " new Chinese medicine Hypertension guideline of clinical investigations ", " the hypertension prevention and control guide " of Evaluation of Diagnostic Criteria of Hypertension reference World Health Organization (WHO) and Chinese hypertension Leagues enact.
The oral liquid of the embodiment 1 group oral embodiment of the present invention 1 every day, every day 2 times, each 30ml; The oral liquid of the embodiment 2 groups oral embodiment of the present invention 2 every day, every day 2 times, each 30ml; The oral liquid of the embodiment 3 groups oral embodiment of the present invention 3 every day, every day 2 times, each 30ml; Matched group takes commercially available chrysanthemum publicly price-reduction tabletting, every day 2 times, each 10.
Criterion of therapeutical effect: with reference to the efficacy of antihypertensive treatment standard formulated in Ministry of Public Health " guideline of clinical investigations of new Chinese medicine Hypertension ".Effective: (1) diastole pressure drop is low≤1.3kPa, and reach normal range; (2) though diastolic pressure does not drop to normally, Xiaed Jiang≤2.7kPa, wherein 1 must have been possessed.Effective: (1) diastolic pressure decline <1.3kPa, but reach normal range; (2) diastolic pressure comparatively treats front decline 1.3-2.5kPa, but does not reach normal range; (3) systolic pressure comparatively treats front decline≤4.0kPa, must possess wherein 1.Invalid: not reach above-mentioned standard.
Therapeutic effect is as table 1:
Table 1
As can be seen from Table 1, in clinical treatment, the present invention's 3 embodiments are to the curative effect of hyperpietic all higher than commercially available depressor chrysanthemum publicly price-reduction tabletting, and wherein the oral liquid antihypertensive effect of embodiment 3 gained is best.
Claims (3)
1. a Chinese medicine oral liquid for blood pressure lowering, is characterized in that, is made up of the crude drug of following weight portion: Radix Astragali 20-25 part, Fructus Corni 15-20 part, Semen Plantaginis 15-20 part, Fructus Gardeniae 10-15 part, Folium Ginkgo 10-15 part, Fructus Schisandrae Chinensis 10-15 part, Fructus Rubi 10-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Fructus Crataegi 10-15 part, Radix Codonopsis 5-10 part, Flos Sophorae 5-10 part, Herba Cistanches 5-10 part, Radix Angelicae Pubescentis 5-10 part, Radix Angelicae Sinensis 5-10 part.
2. according to the Chinese medicine oral liquid of a kind of blood pressure lowering according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: the Radix Astragali 23 parts, Fructus Corni 17 parts, Semen Plantaginis 17 parts, Fructus Gardeniae 12 parts, Folium Ginkgo 12 parts, Fructus Schisandrae Chinensis 12 parts, Fructus Rubi 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Crataegi 12 parts, Radix Codonopsis 7 parts, 7 parts, Flos Sophorae, Herba Cistanches 7 parts, Radix Angelicae Pubescentis 7 parts, Radix Angelicae Sinensis 7 parts.
3. the preparation method of the Chinese medicine oral liquid of a kind of blood pressure lowering described in claim 1 or 2, is characterized in that, make according to the following steps:
(1) take the mixing of each crude drug by weight, add the distilled water immersion of 10 times of weight after 5 hours, decoct twice, first time decocts 30 minutes, and second time decocts 25 minutes;
(2) collecting decoction, filters, is evaporated to every milliliter of decocting liquid and is equivalent to 1 gram of crude drug;
(3) in decocting liquid, add appropriate xylitol, sterilizing, subpackage, to obtain final product.
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| CN104147381B (en) * | 2014-08-25 | 2015-04-22 | 曹荣芳 | Traditional Chinese medicine composition for treating hypertension and preparation method thereof |
| CN107158130B (en) * | 2017-05-13 | 2020-09-29 | 蚌埠永济堂医药有限公司 | Chinese patent medicine for treating hypertension |
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| CN101953918A (en) * | 2010-10-13 | 2011-01-26 | 南方医科大学 | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases |
| CN103041070A (en) * | 2012-12-31 | 2013-04-17 | 青岛华仁信息技术开发有限公司 | Lipid-lowering and pressure-releasing folium ginkgo health-care product and preparation method thereof |
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| KR20120059258A (en) * | 2010-11-30 | 2012-06-08 | 김태현 | Oriental medicine extract having biological activity and manufacturing method thereof |
| JP2012229173A (en) * | 2011-04-26 | 2012-11-22 | Ogawa & Co Ltd | Vascular endothelial function ameliorating agent |
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| CN101953918A (en) * | 2010-10-13 | 2011-01-26 | 南方医科大学 | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases |
| CN103041070A (en) * | 2012-12-31 | 2013-04-17 | 青岛华仁信息技术开发有限公司 | Lipid-lowering and pressure-releasing folium ginkgo health-care product and preparation method thereof |
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| 中医药治疗更年期高血压研究概述;余承云等;《现代中西医结合杂志》;20090131;第18卷(第2期);第218-220页 * |
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Effective date of registration: 20200727 Address after: 063000 No.136 Park Road, Fengrun District, Tangshan City, Hebei Province Patentee after: JINGZHONGSHAN SINOPHARM (TANGSHAN) Co.,Ltd. Address before: 546199 the Guangxi Zhuang Autonomous Region road Laibin City District No. 315 Patentee before: Qin Shu Ren |