CN104147381B - Traditional Chinese medicine composition for treating hypertension and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hypertension and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a traditional Chinese medicine composition for treating hypertension. The traditional Chinese medicine composition is prepared from following medicines: 5-9 parts of eucommia ulmoides, 8-15 parts of mulberry leaves, 12-18 parts of lycium barbarum, 10-20 parts of sophora flower buds, 8-16 parts of radix astragali, 5-15 parts of gingko leaves, 12-18 parts of ligusticum chuanxion, 15-25 parts of gardenia jasminoides, 5-15 parts of dendrobe, 5-10 parts of schisandra chinensis, 12-18 parts of salix leaves and 10-20 parts of rubus idaeus. The traditional Chinese medicine has a significant curative effect in reducing blood pressure without toxic and side effects.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition, more specifically relate to one and treat hypertensive Chinese medicine composition and preparation method thereof.
Background technology
The clinical syndrome that hypertension is is main manifestations with systemic arterial pressure rising, be divided into essential hypertension and secondary hypertension, China is hypertension big country, the health of the mankind in serious harm, therefore improve the understanding to hypertension, have extremely important meaning to early prevention, in time treatment.
The main harm of hypertension is the infringement of heart, brain, kidney, blood vessel, and the heart, brain, kidney, the vascular complication that cause thus.Want accomplish effectively to prevent and treat hypertension, just significantly can reduce incidence rate and the mortality rate of the complication caused by hypertension.Therefore, treating hypertensive main purpose is lower the death of cardiovascular and cerebrovascular disease and the danger of invalid (as paralysis etc.) to greatest extent, and reduces the generation of other complication.Now confirm, effectively control the incidence rate that blood pressure obviously can reduce cardiovascular and cerebrovascular vessel unexpected (myocardial infarction, cerebral infarction), lower mortality rate, extend the life of patient.
One for the treatment of hypertension target blood pressure will be dropped to arm's length standard.All hypertension all should be down to < 140/90 millimetres of mercury, and < 120/80 millimetres of mercury is even more ideal.If during the target organ damages such as hypertension complicated with diabetes mellitus or the heart, brain, kidney, should blood pressure be down to < 130/80 millimetres of mercury or reach desirable level, especially middle-young patients as far as possible.Simple systole hypertension (>=140/90 millimetres of mercury/< 90 millimetres of mercury), also can tune to < 90 millimetres of mercury.Two of target is the M & M reducing cardiovascular and cerebrovascular disease.Three of target reduces the infringement of target organ, causes the infringement of cardiovascular, cerebrovascular and kidney and other organs to be that hypertension controls bad immediate cause.Target organ will be protected in blood pressure lowering process.Four of target reduces poisonous side effect of medicine.Present people are particular about quality of life, get hold of the utilization of medicine, not affect orthobiosis for target.
On market, Chinese medicine Western medicine all has treatment hypertensive, but some medicine takes for a long time and loses blood pressure reduction, some medicines are it is desirable that long-term taking, patient creates dependency to medicine, and common hypertension Western medicine has side effect to health, and especially the side effect of reduction of blood pressure in high-speed medicine is larger, blood pressure of taking medicine then falls, refuse to obey and then rise, certain side effect must be produced to other parts of health in the course of time, and the share that the Western medicine of this blood pressure lowering commercially accounts for is very large.These treat hypertensive chemicals, although effect is fast, cure the symptoms, not the disease, side effect is more, also can produce medicine and rely on, for undesirable patient.
Hypertensive old complaint main cause is: blood, blood vessel, human body gene are impaired, and for impaired organ, it is required that blood circulation promoting and blood stasis dispelling, adjusting blood lipid, vessel softening, recovers the mechanism of regulation and control blood pressure, repairs human body gene defect.Adopt Chinese medicine to effect a permanent cure disease, have letter, just, the feature of honest and clean, effect, without toxicity, patient also takes like a shot.There are many taste medical instruments to have blood circulation promoting and blood stasis dispelling, adjusting blood lipid, vessel softening in Chinese medicinal material, recover the function of the mechanism of regulation and control blood pressure, reached the effect for the treatment of both the principal and secondary aspects of a disease by Chinese traditional treatment hypertension.
Summary of the invention
The invention discloses one and treat hypertensive Chinese medicine composition, this Chinese medicine composition good effect, side effect is little, is the Chinese medicine composition of a kind of safety, treating both the principal and secondary aspects of a disease.
The technical scheme adopted is: a kind of Chinese medicine composition, is made up of the raw material of following parts by weight: Cortex Eucommiae 5-9 part, Folium Mori 8-15 part, Fructus Lycii 12-18 part, Flos Sophorae Immaturus 10-20 part, Radix Astragali 8-16 part, Folium Ginkgo 5-15 part, Rhizoma Chuanxiong 12-18 part, Fructus Gardeniae 15-25 part, Herba Dendrobii 5-15 part, Fructus Schisandrae Chinensis 5-10 part, Folium Salicis Babylonicae 12-18 part, Fructus Rubi 10-20 part.
In Chinese medicine composition of the present invention, the Cortex Eucommiae, another name is thought celestial (" herbal classic "), wood is continuous, think secondary (" not Lu "), Mian (" Bencao Tujing "), Shi Sixian (" Amplification on Materia Medica addendum "), silk gross weight, silk neem bark (" Chinese medicinal herbal "), pull a skin (" Hunan medicine will "), silk flosssilk wadding skin (Soviet Union doctor " Chinese herbal medicine handbook ").Nature and flavor with return through: sweet, temperature.Return liver, kidney channel.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Folium Mori, another name: bilobate, red leaves, Folium Mori, Herba adianti myriosori.Nature and flavor with return through: sweet, bitter, cold.Return lung, Liver Channel.Function with cure mainly: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.1) Folium Mori are good at loose wind heat and let out lung-heat, to affection due to external wind and heat, headache, cough etc., and the fit applications such as normal and Flos Chrysanthemi, Flos Lonicerae, Herba Menthae, Radix Peucedani, Radix Platycodonis.Folium Mori not only can be used for the conjunctival congestion photophobia that wind heat causes, and can clearing away liver-fire, to the conjunctival congestion and swelling pain of flaming up of liver-fire, can with the fit applications such as Flos Chrysanthemi, Semen Cassiae, Semen Plantaginis.As for deficiecny of liver-YIN, eyes is dim-sighted, and Folium Mori also can join Fructus Ligustri Lucidi, Fructus Lycii, the equivalent use of Semen Sesami Nigrum of nourishing the liver and kidney.2) Folium Mori are gently dispersed clearly, wind heat of faling apart, but effect is more weak.Clinical being mainly used in lets out clearly lung liver, as wind heat attacks lung, cough ant phlegm, or dryness-heat impairing the lung, dry cough without phlegm; And wind heat is attacked or the disease such as flaming up of liver-fire, conjunctival congestion and swelling pain, be conventional medicine.Join Fructus Arctii, Radix Peucedani, then loose wind lung heat clearing; Join Gypsum Fibrosum, Radix Ophiopogonis, then clearing away dryness lung moistening; Join Flos Chrysanthemi, Semen Cassiae, then liver heat removing and eyesight improving.
Fructus Lycii (formal name used at school: Lycium chinense) is the multi-branched shrub plant of Solanaceae Lycium, and high 0.5-1 rice, can reach more than 2 meters during cultivation.All there is distribution both at home and abroad.Fructus Lycii whole body is precious, and bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is recorded: " spring adopts Folium Lycii, name sky essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ".Fructus Lycii tender leaf also known as Fructus Lycii head, edible or make Fructus Lycii tea.Modern study, Fructus Lycii has reduction blood glucose, lipotropy, and can antiatherogenic effect.
The Flos Sophorae Immaturus, another name: Bai Huai, Flos Citri grandis, character, alabastrum is avette or oval, and long 2 ~ 6mm, diameter is about 2mm.Calyx yellow green, several longitudinal grins are arranged at bottom.The top of calyx is the unopened petal of yellow-white.Bennet is tiny.Body is light, hands sth. made by twisting and broken.Odorless, mildly bitter flavor is puckery.Function cures mainly, flower (Flos Sophorae) cooling blood for hemostasis; Fruit (Fructus Sophorae) clearing away heat-fire.
The Radix Astragali have tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promote the production of body fluid nourish blood, row stagnant blood stasis dispelling, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation effect.Folium Ginkgo, another name moth leaf, duck bottom sediment, nature and flavor are sweet, bitter, puckery, flat.GUIXIN, lung meridian.Function cures mainly, and astringes the lung, and relievings asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia.
The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.
Fructus Gardeniae: sweet, bitter, cold.Return liver, gallbladder, stomach warp.Clearing away heat-damp and promoting diuresis, cooling blood for hemostasis.Main icterohepatitis, dysentery, cholecystitis, the high heat of flu, spits blood, epistaxis, urinary tract infection, oedema due to nephritis, mastitis, acute toothache, sore and toxic, traumatic injury.
Herba Dendrobii, another name: Lin Lan, taboo life, Du Lan, Dendrobium nobile Lindl flower, Qian Nianrun, Dendrobium denneanum Kerr., bracketplant.Nature and flavor with return through: sweet, be slightly cold.Return stomach, kidney channel.Function with cure mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Fructus Schisandrae Chinensis, is commonly called as Fructus Zanthoxyli Plansipini, sliding weight of steelyard, medicine Fructus Schisandrae Chinensis, face rattan, five Fructus Armeniacae Mumes etc., Tang etc. " Newly Revised Canon of Materia Medica " carry " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of Fructus Schisandrae Chinensis.Ancient medical book Cheng Ta Chi Zhu, profound and, meeting and, it is top grade to list in Sheng Nong's herbal classic the earliest, and herbal function is the power of strengthening by means of tonics, medical value is high, and it has astringes the lung, nourishing kidney, promote the production of body fluid, receive antiperspirant, effect of arresting seminal emission, clinically be mainly used in treatment and control the deficiency of the lung and breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, the diseases such as chronic diarrhea chronic dysentery.Modern pharmacology confirms, its extract has stronger hepatoprotective and sedation.
Folium Salicis Babylonicae is bitter, cold in nature; Return lung, kidney, heart channel; Function cures mainly: heat clearing away; Removing toxic substances; Diuresis; Suppressing the hyperactive liver; Pain relieving; Rash.Main chronic tracheitis; Urethritis; Cystitis; Vesical calculus; Nebulousurine; Hypertension; Swollen ulcer drug; Burn and scald; Arthralgia; Toothache; Acute diseases such as cholera and sunstroke rash; Skin pruritus.
Fructus Rubi, another name, covers basin, black Fischer, little pallet, Shan Pao, Jin Fischer; Nature and flavor: warm in nature, sweet in the mouth, acid.Return liver, kidney; Function cures mainly: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Main impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, and leukorrhagia is rare clearly, frequent micturition incontinence of urine, and blurred vision is dark, early whitening of beard and hair.
The present invention treats hypertensive Chinese medicine and is mainly used in blood circulation promoting and blood stasis dispelling, and the method such as stasis-dispelling and pain-killing, removing damp-heat from the liver and the gallbladder is treated.After Chinese medicine composition combination of the present invention, there is significant blood pressure lowering effect.The parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after drug matching uses medicine to the enhancing for the treatment of antihypertensive effect.As a most preferred embodiment of the present invention, Chinese medicine composition of the present invention is made up of the raw material of following parts by weight: the Cortex Eucommiae 7 parts, 12 parts, Folium Mori, Fructus Lycii 16 parts, the Flos Sophorae Immaturus 15 parts, the Radix Astragali 12 parts, Folium Ginkgo 9 parts, Rhizoma Chuanxiong 16 parts, Fructus Gardeniae 20 parts, Herba Dendrobii 10 parts, Fructus Schisandrae Chinensis 8 parts, Folium Salicis Babylonicae 16 parts, Fructus Rubi 16 parts.
Present invention also offers a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: get the above-mentioned 12 taste Chinese crude drugs of recipe quantity, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis add 150-300 weight parts water and extract to obtain volatile oil, and medicinal residues are for subsequent use, volatile oil when 45-65 DEG C by 5-9 weight portion beta-schardinger dextrin-inclusion, for subsequent use, it is 1.12 ~ 1.16 that remaining concentration of liquid medicine to 50 DEG C measures relative density, adds ethanol and makes alcohol content be 50%, medicinal residues and Folium Mori, Fructus Lycii, the Flos Sophorae Immaturus, the Radix Astragali, Folium Ginkgo, Folium Salicis Babylonicae, Fructus Rubi decocts with water secondary, add water 100-150 weight portion for the first time, decoct 1-3 hour, add water 80-150 weight portion for the second time, decoct 0.5-2 hour, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, temperature is 45-75 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.12 ~ 1.16, let cool, adding ethanol makes alcohol content be 50%, leave standstill, filter, filtrate and above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, the alcohol liquid of Fructus Schisandrae Chinensis merges, decompression recycling ethanol, pressure is-0.08Mpa, temperature is 45-75 DEG C, be concentrated into 50 DEG C and measure relative density 1.12 ~ 1.16, the Cortex Eucommiae is separately decocted, decoct with water secondary, add water 80-200 weight portion for the first time, decocts 1-3 hour, add water 80-150 weight portion for the second time, decoct 0.5-2 hour, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, and temperature is 45-75 DEG C, is concentrated into the clear paste that 50 DEG C measure relative density 1.12 ~ 1.16, let cool, adding ethanol makes alcohol content be 50%, leaves standstill, and filters, decompression filtrate recycling ethanol, pressure is-0.08Mpa, and temperature is 45-75 DEG C, is concentrated into 50 DEG C and measures relative density 1.12 ~ 1.16, merged by above-mentioned concentrated solution, stir evenly, mesh screen filters, concentrated, adds above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis clathrate, dextrin and aspartame, and mixing is granulated, and dry, granulate, namely available conventional formulation method makes clinical receptible various dosage form.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Be preferably, powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, tablet, capsule etc.More preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into granule, tablet or capsule.
Chinese medicine composition of the present invention is known by pharmacodynamics test, the therapeutic outcome of spontaneous hypertensive rat blood pressure is shown, in medicine of the present invention dosage group and heavy dose of group gastric infusion after 15 days with administration before and model control group comparing difference significantly (P<0.01); Medicine small dose group gastric infusion of the present invention after 15 days with compare before administration reduce blood pressure significantly (P<0.05), medicine small dose group gastric infusion of the present invention compares with model control group after 15 days reduce blood pressure more remarkable (P<0.01), and medicine small dose group gastric infusion of the present invention compares with model control group reduce blood pressure more remarkable (P<0.01) after 45 days with before administration.Simultaneously the present composition and Nifedipine group can effective reversing hypertension rat left chamber myocardial hypertrophies, and the heavy dose of group of the present invention is better than positive controls, this demonstrate that the treatment of Chinese medicine composition of the present invention to spontaneous hypertensive rat myocardial hypertrophy achieves good synergism.
In addition, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improves the compliance of hyperpietic, and improves the quality of life of patient.Raw material of Chinese medicine medicine compatibility of the present invention is reasonable, complements each other, well can treat hypertension.Chinese Traditional Herbs Drug Clinical Testing of the present invention treats 329 examples altogether, and total effective rate reaches 97.8%.Wherein criterion of therapeutical effect: recovery from illness: symptom all disappears, and blood pressure inspection is normal; Effective: symptom disappears substantially, diastolic pressure and systolic pressure obviously reduce; Invalid: symptom is not improved.Instructions of taking: take granule described in invention compositions embodiment 1 every day 1-2 time, serve on 3 months.To 329 hyperpietics, adopt Chinese medicine composition of the present invention to carry out and followed the tracks for the treatment of.Wherein, cure 310 examples, account for 94.2%; Effective 12 examples, account for 3.6%; Invalid 8 examples, account for 2.4%; Total effective rate is about 97.8%.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 Chinese medicinal composition granules
Prescription: be made up of the raw material of following parts by weight: the Cortex Eucommiae 7 parts, 12 parts, Folium Mori, Fructus Lycii 16 parts, the Flos Sophorae Immaturus 15 parts, the Radix Astragali 12 parts, Folium Ginkgo 9 parts, Rhizoma Chuanxiong 16 parts, Fructus Gardeniae 20 parts, Herba Dendrobii 10 parts, Fructus Schisandrae Chinensis 8 parts, Folium Salicis Babylonicae 16 parts, Fructus Rubi 16 parts.
Preparation technology: get the above-mentioned 12 taste Chinese crude drugs of recipe quantity, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis are added 220 weight parts waters and extract to obtain volatile oil, and medicinal residues are for subsequent use, volatile oil 55 DEG C time by 7 weight portion beta-schardinger dextrin-inclusions, for subsequent use, it is 1.13 ~ 1.15 that remaining concentration of liquid medicine to 50 DEG C measures relative density, adds ethanol and makes alcohol content be 50%, medicinal residues and Folium Mori, Fructus Lycii, the Flos Sophorae Immaturus, the Radix Astragali, Folium Ginkgo, Folium Salicis Babylonicae, Fructus Rubi decocts with water secondary, add water 120 weight portions for the first time, decoct 2 hours, add water 120 weight portions for the second time, decoct 1.5 hours, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, temperature is 65 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.13 ~ 1.15, let cool, adding ethanol makes alcohol content be 50%, leave standstill, filter, filtrate and above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, the alcohol liquid of Fructus Schisandrae Chinensis merges, decompression recycling ethanol, pressure is-0.08Mpa, temperature is 65 DEG C, be concentrated into 50 DEG C and measure relative density 1.13 ~ 1.15, the Cortex Eucommiae is separately decocted, and decocts with water secondary, and add water 150 weight portions for the first time, decocts 2 hours, add water 120 weight portions for the second time, decocts 1.5 hours, collecting decoction, filters, concentrating under reduced pressure, pressure is-0.08Mpa, and temperature is 65 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.13 ~ 1.15, let cool, add ethanol and make alcohol content be 50%, leave standstill, filter, decompression filtrate recycling ethanol, pressure is-0.08Mpa, and temperature is 65 DEG C, is concentrated into 50 DEG C and measures relative density 1.13 ~ 1.15, merged by above-mentioned concentrated solution, stir evenly, mesh screen filters, concentrated, adds above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis clathrate, dextrin and aspartame, and mixing is granulated, and dry, granulate, makes granule by conventional formulation method.
The agent of embodiment 2 Chinese medicinal composition capsules
Prescription: be made up of the raw material of following parts by weight: the Cortex Eucommiae 5 parts, 8 parts, Folium Mori, Fructus Lycii 12 parts, the Flos Sophorae Immaturus 10 parts, the Radix Astragali 8 parts, Folium Ginkgo 5 parts, Rhizoma Chuanxiong 12 parts, Fructus Gardeniae 15 parts, Herba Dendrobii 5 parts, Fructus Schisandrae Chinensis 5 parts, Folium Salicis Babylonicae 12 parts, Fructus Rubi 10 parts.
Preparation technology: get the above-mentioned 12 taste Chinese crude drugs of recipe quantity, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis are added 220 weight parts waters and extract to obtain volatile oil, and medicinal residues are for subsequent use, volatile oil 55 DEG C time by 7 weight portion beta-schardinger dextrin-inclusions, for subsequent use, it is 1.13 ~ 1.15 that remaining concentration of liquid medicine to 50 DEG C measures relative density, adds ethanol and makes alcohol content be 50%, medicinal residues and Folium Mori, Fructus Lycii, the Flos Sophorae Immaturus, the Radix Astragali, Folium Ginkgo, Folium Salicis Babylonicae, Fructus Rubi decocts with water secondary, add water 120 weight portions for the first time, decoct 2 hours, add water 120 weight portions for the second time, decoct 1.5 hours, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, temperature is 65 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.13 ~ 1.15, let cool, adding ethanol makes alcohol content be 50%, leave standstill, filter, filtrate and above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, the alcohol liquid of Fructus Schisandrae Chinensis merges, decompression recycling ethanol, pressure is-0.08Mpa, temperature is 65 DEG C, be concentrated into 50 DEG C and measure relative density 1.13 ~ 1.15, the Cortex Eucommiae is separately decocted, and decocts with water secondary, and add water 150 weight portions for the first time, decocts 2 hours, add water 120 weight portions for the second time, decocts 1.5 hours, collecting decoction, filters, concentrating under reduced pressure, pressure is-0.08Mpa, and temperature is 65 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.13 ~ 1.15, let cool, add ethanol and make alcohol content be 50%, leave standstill, filter, decompression filtrate recycling ethanol, pressure is-0.08Mpa, and temperature is 65 DEG C, is concentrated into 50 DEG C and measures relative density 1.13 ~ 1.15, merged by above-mentioned concentrated solution, stir evenly, mesh screen filters, concentrated, adds above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis clathrate, dextrin and aspartame, and mixing is granulated, and dry, granulate, makes capsule by conventional formulation method.
Embodiment 3 Chinese medicine composition tablet
Prescription: be made up of the raw material of following parts by weight: the Cortex Eucommiae 9 parts, 15 parts, Folium Mori, Fructus Lycii 18 parts, the Flos Sophorae Immaturus 20 parts, the Radix Astragali 16 parts, Folium Ginkgo 15 parts, Rhizoma Chuanxiong 18 parts, Fructus Gardeniae 25 parts, Herba Dendrobii 15 parts, Fructus Schisandrae Chinensis 10 parts, Folium Salicis Babylonicae 18 parts, Fructus Rubi 20 parts.
Preparation technology: get the above-mentioned 12 taste Chinese crude drugs of recipe quantity, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis are added 220 weight parts waters and extract to obtain volatile oil, and medicinal residues are for subsequent use, volatile oil 55 DEG C time by 7 weight portion beta-schardinger dextrin-inclusions, for subsequent use, it is 1.13 ~ 1.15 that remaining concentration of liquid medicine to 50 DEG C measures relative density, adds ethanol and makes alcohol content be 50%, medicinal residues and Folium Mori, Fructus Lycii, the Flos Sophorae Immaturus, the Radix Astragali, Folium Ginkgo, Folium Salicis Babylonicae, Fructus Rubi decocts with water secondary, add water 120 weight portions for the first time, decoct 2 hours, add water 120 weight portions for the second time, decoct 1.5 hours, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, temperature is 65 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.13 ~ 1.15, let cool, adding ethanol makes alcohol content be 50%, leave standstill, filter, filtrate and above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, the alcohol liquid of Fructus Schisandrae Chinensis merges, decompression recycling ethanol, pressure is-0.08Mpa, temperature is 65 DEG C, be concentrated into 50 DEG C and measure relative density 1.13 ~ 1.15, the Cortex Eucommiae is separately decocted, and decocts with water secondary, and add water 150 weight portions for the first time, decocts 2 hours, add water 120 weight portions for the second time, decocts 1.5 hours, collecting decoction, filters, concentrating under reduced pressure, pressure is-0.08Mpa, and temperature is 65 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.13 ~ 1.15, let cool, add ethanol and make alcohol content be 50%, leave standstill, filter, decompression filtrate recycling ethanol, pressure is-0.08Mpa, and temperature is 65 DEG C, is concentrated into 50 DEG C and measures relative density 1.13 ~ 1.15, merged by above-mentioned concentrated solution, stir evenly, mesh screen filters, concentrated, adds above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis clathrate, dextrin and aspartame, and mixing is granulated, and dry, granulate, makes tablet by conventional formulation method.
Embodiment 4 Chinese medicine composition tablet
Prescription: be made up of the raw material of following parts by weight: the Cortex Eucommiae 5 parts, 15 parts, Folium Mori, Fructus Lycii 12 parts, the Flos Sophorae Immaturus 20 parts, the Radix Astragali 8 parts, Folium Ginkgo 15 parts, Rhizoma Chuanxiong 12 parts, Fructus Gardeniae 25 parts, Herba Dendrobii 5 parts, Fructus Schisandrae Chinensis 10 parts, Folium Salicis Babylonicae 12 parts, Fructus Rubi 20 parts.
Preparation technology: get the above-mentioned 12 taste Chinese crude drugs of recipe quantity, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis add 150 weight parts waters and extract to obtain volatile oil, and medicinal residues are for subsequent use, volatile oil 45 DEG C time by 9 weight portion beta-schardinger dextrin-inclusions, for subsequent use, it is 1.12 ~ 1.14 that remaining concentration of liquid medicine to 50 DEG C measures relative density, adds ethanol and makes alcohol content be 50%, medicinal residues and Folium Mori, Fructus Lycii, the Flos Sophorae Immaturus, the Radix Astragali, Folium Ginkgo, Folium Salicis Babylonicae, Fructus Rubi decocts with water secondary, add water 100 weight portions for the first time, decoct 3 hours, add water 80 weight portions for the second time, decoct 2 hours, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, temperature is 45 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.12 ~ 1.14, let cool, adding ethanol makes alcohol content be 50%, leave standstill, filter, filtrate and above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, the alcohol liquid of Fructus Schisandrae Chinensis merges, decompression recycling ethanol, pressure is-0.08Mpa, temperature is 45 DEG C, be concentrated into 50 DEG C and measure relative density 1.12 ~ 1.14, the Cortex Eucommiae is separately decocted, and decocts with water secondary, and add water 80 weight portions for the first time, decocts 3 hours, add water 80 weight portions for the second time, decocts 2 hours, collecting decoction, filters, concentrating under reduced pressure, pressure is-0.08Mpa, and temperature is 45 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.12 ~ 1.14, let cool, add ethanol and make alcohol content be 50%, leave standstill, filter, decompression filtrate recycling ethanol, pressure is-0.08Mpa, and temperature is 45 DEG C, is concentrated into 50 DEG C and measures relative density 1.12 ~ 1.14, merged by above-mentioned concentrated solution, stir evenly, mesh screen filters, concentrated, adds above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis clathrate, dextrin and aspartame, and mixing is granulated, and dry, granulate, makes tablet by conventional formulation method.
Embodiment 5 Chinese medicine composition tablet
Prescription: be made up of the raw material of following parts by weight: the Cortex Eucommiae 9 parts, 8 parts, Folium Mori, Fructus Lycii 18 parts, the Flos Sophorae Immaturus 10 parts, the Radix Astragali 16 parts, Folium Ginkgo 5 parts, Rhizoma Chuanxiong 18 parts, Fructus Gardeniae 15 parts, Herba Dendrobii 15 parts, Fructus Schisandrae Chinensis 5 parts, Folium Salicis Babylonicae 18 parts, Fructus Rubi 10 parts.
Preparation technology: get the above-mentioned 12 taste Chinese crude drugs of recipe quantity, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis add 300 weight parts waters and extract to obtain volatile oil, and medicinal residues are for subsequent use, volatile oil 65 DEG C time by 5 weight portion beta-schardinger dextrin-inclusions, for subsequent use, it is 1.14 ~ 1.16 that remaining concentration of liquid medicine to 50 DEG C measures relative density, adds ethanol and makes alcohol content be 50%, medicinal residues and Folium Mori, Fructus Lycii, the Flos Sophorae Immaturus, the Radix Astragali, Folium Ginkgo, Folium Salicis Babylonicae, Fructus Rubi decocts with water secondary, add water 150 weight portions for the first time, decoct 1 hour, add water 150 weight portions for the second time, decoct 0.5 hour, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, temperature is 75 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.14 ~ 1.16, let cool, adding ethanol makes alcohol content be 50%, leave standstill, filter, filtrate and above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, the alcohol liquid of Fructus Schisandrae Chinensis merges, decompression recycling ethanol, pressure is-0.08Mpa, temperature is 75 DEG C, be concentrated into 50 DEG C and measure relative density 1.14 ~ 1.16, the Cortex Eucommiae is separately decocted, and decocts with water secondary, and add water 200 weight portions for the first time, decocts 1 hour, add water 150 weight portions for the second time, decocts 0.5 hour, collecting decoction, filters, concentrating under reduced pressure, pressure is-0.08Mpa, and temperature is 75 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.14 ~ 1.16, let cool, add ethanol and make alcohol content be 50%, leave standstill, filter, decompression filtrate recycling ethanol, pressure is-0.08Mpa, and temperature is 75 DEG C, is concentrated into 50 DEG C and measures relative density 1.14 ~ 1.16, merged by above-mentioned concentrated solution, stir evenly, mesh screen filters, concentrated, adds above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis clathrate, dextrin and aspartame, and mixing is granulated, and dry, granulate, makes tablet by conventional formulation method.
Embodiment 6 Chinese medicine composition tablet
Prescription: be made up of the raw material of following parts by weight: the Cortex Eucommiae 9 parts, 15 parts, Folium Mori, Fructus Lycii 18 parts, the Flos Sophorae Immaturus 10 parts, the Radix Astragali 8 parts, Folium Ginkgo 5 parts, Rhizoma Chuanxiong 18 parts, Fructus Gardeniae 25 parts, Herba Dendrobii 5 parts, Fructus Schisandrae Chinensis 5 parts, Folium Salicis Babylonicae 12 parts, Fructus Rubi 10 parts.
Preparation technology: get the above-mentioned 12 taste Chinese crude drugs of recipe quantity, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis add 300 weight parts waters and extract to obtain volatile oil, and medicinal residues are for subsequent use, volatile oil 60 DEG C time by 7 weight portion beta-schardinger dextrin-inclusions, for subsequent use, it is 1.13 ~ 1.15 that remaining concentration of liquid medicine to 50 DEG C measures relative density, adds ethanol and makes alcohol content be 50%, medicinal residues and Folium Mori, Fructus Lycii, the Flos Sophorae Immaturus, the Radix Astragali, Folium Ginkgo, Folium Salicis Babylonicae, Fructus Rubi decocts with water secondary, add water 110 weight portions for the first time, decoct 2.5 hours, add water 100 weight portions for the second time, decoct 1 hour, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, temperature is 60 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.13 ~ 1.15, let cool, adding ethanol makes alcohol content be 50%, leave standstill, filter, filtrate and above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, the alcohol liquid of Fructus Schisandrae Chinensis merges, decompression recycling ethanol, pressure is-0.08Mpa, temperature is 60 DEG C, be concentrated into 50 DEG C and measure relative density 1.13 ~ 1.15, the Cortex Eucommiae is separately decocted, and decocts with water secondary, and add water 150 weight portions for the first time, decocts 1.5 hours, add water 100 weight portions for the second time, decocts 1.5 hours, collecting decoction, filters, concentrating under reduced pressure, pressure is-0.08Mpa, and temperature is 60 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.13 ~ 1.15, let cool, add ethanol and make alcohol content be 50%, leave standstill, filter, decompression filtrate recycling ethanol, pressure is-0.08Mpa, and temperature is 60 DEG C, is concentrated into 50 DEG C and measures relative density 1.13 ~ 1.15, merged by above-mentioned concentrated solution, stir evenly, mesh screen filters, concentrated, adds above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis clathrate, dextrin and aspartame, and mixing is granulated, and dry, granulate, makes tablet by conventional formulation method.
Embodiment 7: the pharmacodynamics test of Chinese medicine composition of the present invention
1. Chinese medicine composition of the present invention is on the impact of spontaneous hypertensive rat blood pressure
Spontaneous hypertensive rat 50, male and female half and half, body weight 300 ± 20g, five groups are divided at random by body weight, i.e. drug bolus group 40.0mg/kg of the present invention (Chinese medicine composition presses crude drug gauge), middle dosage group 20.0mg/kg (Chinese medicine composition is by crude drug gauge), small dose group 10.0mg/kg (Chinese medicine composition is by crude drug gauge), positive drug Nifedipine group 20mg/kg, model control group, often organizes 10.Gastric infusion volume is 1ml/200g, and model control group gives isopyknic 0.5% sodium carboxymethyl cellulose.
Each group is gastric infusion, once a day.In experimentation, observe animal diet followed, survival condition and behavioral activity every day, every day measures body weight, according to body weight adjustment drug dose.Put to death animal after 8 weeks, dirty survey left ventricular mass of coring, calculates left room index.
Temperature controls at 18 DEG C-22 DEG C, temperature 45%-65%, Indoor Natural light.With tail arterial blood pressure under BP-2006A intelligence non-invasive blood pressure measuring measurement rat waking state.Within 5th, 15,30 day, distinguish Measure blood pressure with method upon administration, all measure 5 times between 2 hours to 5 hours after gastric infusion, get the blood pressure of its average as this sample.
Result shows, in medicine of the present invention dosage group and heavy dose of group gastric infusion after 15 days with administration before and model control group comparing difference significantly (P<0.01).Medicine small dose group gastric infusion of the present invention after 15 days with compare before administration reduce blood pressure significantly (P<0.05), medicine small dose group gastric infusion of the present invention compares with model control group after 15 days reduce blood pressure more remarkable (P<0.01), and medicine small dose group gastric infusion of the present invention compares with model control group reduce blood pressure more remarkable (P<0.01) after 15 days with before administration.The results detailed in Table 1.
Table 1 medicine of the present invention on the impact of spontaneous hypertensive rat systolic blood pressure (mmHg) (
n=10)
Note: compared with before medicine,
*p<0.05,
*p<0.01; Compared with model group,
#p<0.05,
##p<0.01
2. cardiac weight, left ventricular mass, body weight and left ventricular hypertrophy index (left ventricular mass/body weight) measure:
With 10% potassium chloride (2mmol/L, 1ml/ is only) put to death rat after, survey body weight, take out heart, remove the outer connective tissue of atrium, trunk and heart, rinse well, filter paper blots rear removal atrium, claim left ventricular mass, calculate left ventricular hypertrophy index (left ventricular mass and body weight ratio), the results are shown in Table 2.
Table 2 hypertension compound recipe on the impact of spontaneous hypertensive rat myocardial hypertrophy (
n=10)
Note: compare with model group
*p < 0.05,
*p < 0.01; Compare with positive controls,
#p < 0.05,
##p < 0.01.
Result shows, contrast with model group, Chinese medicine composition of the present invention and Nifedipine group can effective reversing hypertension rat left chamber myocardial hypertrophies, and in the present invention, dosage group and heavy dose of group are better than positive controls, this demonstrate that the treatment of the present composition to spontaneous hypertensive rat myocardial hypertrophy achieves good synergism.
Claims (3)
1. the hypertensive Chinese medicine composition for the treatment of, it is characterized in that, it is made up of the raw material of following parts by weight: the Cortex Eucommiae 7 parts, 12 parts, Folium Mori, Fructus Lycii 16 parts, the Flos Sophorae Immaturus 15 parts, the Radix Astragali 12 parts, Folium Ginkgo 9 parts, Rhizoma Chuanxiong 16 parts, Fructus Gardeniae 20 parts, Herba Dendrobii 10 parts, Fructus Schisandrae Chinensis 8 parts, Folium Salicis Babylonicae 16 parts, Fructus Rubi 16 parts.
2. prepare a method for Chinese medicine composition as claimed in claim 1, it is characterized in that, it comprises the following steps:
In 12 taste Chinese medicines according to claim 1, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis add 150-300 weight parts water and extract to obtain volatile oil, and medicinal residues are for subsequent use; Volatile oil when 45-65 DEG C by 5-9 weight portion beta-schardinger dextrin-inclusion, for subsequent use; It is 1.12 ~ 1.16 that remaining concentration of liquid medicine to 50 DEG C measures relative density, adds ethanol and makes alcohol content be 50%;
Medicinal residues and Folium Mori, Fructus Lycii, the Flos Sophorae Immaturus, the Radix Astragali, Folium Ginkgo, Folium Salicis Babylonicae, Fructus Rubi decocts with water secondary, add water 100-150 weight portion for the first time, decoct 1-3 hour, add water 80-150 weight portion for the second time, decoct 0.5-2 hour, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, temperature is 45-75 DEG C, be concentrated into the clear paste that 50 DEG C measure relative density 1.12 ~ 1.16, let cool, adding ethanol makes alcohol content be 50%, leave standstill, filter, filtrate and above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, the alcohol liquid of Fructus Schisandrae Chinensis merges, decompression recycling ethanol, pressure is-0.08Mpa, temperature is 45-75 DEG C, be concentrated into 50 DEG C and measure relative density 1.12 ~ 1.16,
The Cortex Eucommiae is separately decocted, decoct with water secondary, add water 80-200 weight portion for the first time, decocts 1-3 hour, add water 80-150 weight portion for the second time, decoct 0.5-2 hour, collecting decoction, filter, concentrating under reduced pressure, pressure is-0.08Mpa, and temperature is 45-75 DEG C, is concentrated into the clear paste that 50 DEG C measure relative density 1.12 ~ 1.16, let cool, adding ethanol makes alcohol content be 50%, leaves standstill, and filters, decompression filtrate recycling ethanol, pressure is-0.08Mpa, and temperature is 45-75 DEG C, is concentrated into 50 DEG C and measures relative density 1.12 ~ 1.16;
Merged by above-mentioned concentrated solution, stir evenly, mesh screen filters, concentrated, adds above-mentioned Rhizoma Chuanxiong, Fructus Gardeniae, Herba Dendrobii, Fructus Schisandrae Chinensis clathrate, dextrin and aspartame, and mixing is granulated, and dry, granulate, to obtain final product.
3. the preparation method of Chinese medicine composition according to claim 2, it is characterized in that, described Chinese medicine composition is granule, tablet or capsule.
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