CN103041309B - A kind of beauty folium ginkgo oral liquid and preparation method thereof - Google Patents

Abstract

A kind of beauty folium ginkgo oral liquid, in oral liquid for beauty, various raw material is: Folium Ginkgo, Herba Leonuri, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Salviae Miltiorrhizae, Poria, Flos persicae, Radix Curcumae, Fructus Ligustri Lucidi, Flos Inulae, Flos Campsis, Radix Scutellariae, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Flos Albiziae, propolis, Caulis Spatholobi.Semen Ginkgo extrac has very strong scavenging free radicals and antioxidation, yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, check melanin grows, and keeps skin gloss and elasticity to play no small effect, is applicable to long-term taking.The invention solves the virose shortcoming of Folium Ginkgo, and remain the beneficiating ingredient of Folium Ginkgo greatly, on the make avoid secondary pollution, is the health product of green health environmental protection completely.Add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, improves blood circulation of human body and liver detoxification ability, reaches the effect beautifying skin.

Description

A kind of beauty folium ginkgo oral liquid and preparation method thereof

Technical field

The present invention relates to the cosmetic health product containing deriving from plant composition, particularly a kind of beauty folium ginkgo oral liquid and preparation method thereof.

Background technology

Folium Ginkgo is a kind of plant with very high medical value, and ginkgo is one of ancient seeds of China, and it is the tree of magical medical treatment, and before more than 200,000,000 5 thousand year, dinosaur controls terrestrial time Jurassic Period, and Semen Ginkgo is one of the most flouring plant.Life on earth goes through the variation of 100000000000 years, especially after the glacier covering of the 4th century, only has Semen Ginkgo still to keep its most original looks, organic evolution history is called as " living fossil ".Its leaf, fruit, seed have higher medical value, and its pharmacological action is constantly familiar with, and clinical application range progressively expands.Ginkgo has another name called maidenhair tree, is the rarity of China, rare valuable, is described as " hollywood lignumvitae ", " living fossil " of the earth.

The living and diet of modern people is too meticulous, and quantity of motion reduces, or eating and drinking too much at one meal, or overstrain, body metabolism function is failed gradually, causes visceral dysfunction, easily cause the pigmented lesion such as chloasma faciei, freckle.The traditional Chinese medical science is thought, facial colour spot is that blood deficiency is not dissolved in face because of zang-fu differentiation qi and blood disorder; Or because of internal injury caused by excess of seven emotions, stagnation of QI due to depression of the liver, incoordination between the liver and spleen; Or because of improper diet and overtiredness, menoxenia; Or because of the blood system of fire stagnation meridians, ailment said due to cold or exposure is rich outward and caused by sending out.Adopt this kind of disease of western medicine, be mostly outer wiping or vitamins for oral administration, flavonols medicine.Because pathogenesis is more, adopt western medicine effect to differ, also not easily effect a radical cure, some medicine side effect is larger.

Containing the multiple components that natural activity flavone and amarolide etc. are useful with health in Folium Ginkgo, there is dissolving cholesterol, the effect of blood vessel dilating, has positive effect to improving disordered brain function, arteriosclerosis, hypertension, dizzy, tinnitus, headache, senile dementia, hypomnesis etc.Its diseases prevention, cure the disease, the value of body-building is early on the books in the Compendium of Material Medica of Ming Dynasty's Li Shizhen (1518-1593 A.D.).Detect through national health department and prove: drink Folium Ginkgo tea and obviously can reduce serum cholesterol, triglyceride and low-density blood lipoprotein, reduce the effect of depot lipid in body.Fat-reducing etc. for the adjustment of hyperlipidemia, the complementary control of diseases of cardiovascular and cerebrovascular systems patient such as hypertension and coronary heart disease and obese type crowd has good effect, is the desirable beverage of prophylactic treatment senile dementia.Be recognized in the worldly to control, the optimal pharmaceutical compositions of anti-cardiovascular and cerebrovascular disease.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Though Folium Ginkgo energy blood circulation promoting, prevention cardiovascular diseases, but can not be taken other simultaneously and control cardiovascular drugs (such as aspirin), Semen Ginkgo extrac has very strong scavenging free radicals and antioxidation, yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, check melanin grows, and keeps skin gloss and elasticity to play no small effect.In addition, according to modern clinical research, to the chronic schizophrenia of (as social withdrawal, slack, the poverty of thought, the symptom such as dull) has remarkable result based on negative symptoms, certain effect is also had to cerebellar atrophy (senile dementia).

The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, old people will stop before going too far when taking Folium Ginkgo, and notes periodic detection blood coagulation situation, not blindness long-term taking.For the patient that existing senile sclerosis of blood vessels, blood vessel become fragile, more can not long-term taking, in order to avoid cause cerebral hemorrhage.Folium Ginkgo together can not brew up with Folium Camelliae sinensis and Flos Chrysanthemi.

Although ginkgo Leaves health care effect is very strong, Folium Ginkgo, containing toxic component, brews up with it and can cause clonospasm, neural paralysis, platycoria, allergy and other side effect.Anemia of pregnant woman and child, old man is careful.Have a kind of composition in Folium Ginkgo ginkgoic acid, if dosage excessive, or Time of Administration is long, can damage heart.Containing a large amount of ginkgoic acids in Semen Ginkgo, ginkgoic acid is containing virose, the leaf generally bought is without deep processing and extraction, the ginkgoic acid content of the inside is up to 3000-4000ppm, special ginkgoic acid is water miscible, one soaked Semen Ginkgo pyrite and the active substance such as Semen Ginkgo lactone not only not having the inside, effect is contrary on the contrary, and the inside is poison entirely.

Although ginkgo Leaves health care effect is very strong, Folium Ginkgo, containing toxic component, brews up with it and can cause clonospasm, neural paralysis, platycoria, allergy and other side effect.Ginkgoic acid, improper use or dosage are too large, are easy to cause poisoning.So at present in the urgent need to a kind of technique, can the health-care effect of application Folium Ginkgo, make again its poisonous material drop to minimum.Anemia of pregnant woman and child, old man is careful.Have a kind of composition in Folium Ginkgo ginkgoic acid, if dosage excessive, or Time of Administration is long, can damage heart.But anemia of pregnant woman of the present invention and child, old man is careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, old people will stop before going too far when taking Folium Ginkgo, and notes periodic detection blood coagulation situation, not blindness long-term taking.For the patient that existing senile sclerosis of blood vessels, blood vessel become fragile, more can not long-term taking, in order to avoid cause cerebral hemorrhage.Have a kind of composition in Folium Ginkgo ginkgoic acid, if dosage excessive, or Time of Administration is long, can damage heart.

There is a lot of defect in prior art, Folium Ginkgo, containing toxic component, brews up with it and can cause clonospasm, neural paralysis, platycoria, allergy and other side effect; Have a kind of composition in Folium Ginkgo ginkgoic acid, if dosage excessive, or Time of Administration is long, can damage heart.Semen Ginkgo extrac has very strong scavenging free radicals and antioxidation, and the yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, and check melanin grows, and keeps skin gloss and elasticity to play no small effect.The invention solves the virose shortcoming of Folium Ginkgo; And remaining the beneficiating ingredient of Folium Ginkgo greatly, make it not have work in-process to run off, on the make avoid secondary pollution, is the health product of green health environmental protection completely.Add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulate the metabolism function of human body, improve blood circulation of human body and liver detoxification ability, reach the effect beautifying skin.

For solving above-mentioned technical barrier, the invention provides a kind of beauty folium ginkgo oral liquid, in described beauty folium ginkgo oral liquid, the parts by weight of various raw material are: Folium Ginkgo 10 ~ 30 parts, Herba Leonuri 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Poria, 10 ~ 20 parts, Flos persicae, Radix Curcumae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Flos Inulae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, propolis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts.

Described beauty folium ginkgo oral liquid, in beauty folium ginkgo oral liquid described in it, the parts by weight of various raw material can also be preferably: Folium Ginkgo 10 ~ 30 parts, Herba Leonuri 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, 10 ~ 15 parts, Poria, 10 ~ 15 parts, Flos persicae, Radix Curcumae 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Flos Inulae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, propolis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts.

Described Semen Ginkgo oral liquid for beauty, in beauty folium ginkgo oral liquid described in it, the parts by weight of various raw material also can be preferably: Folium Ginkgo 10 ~ 30 parts, Herba Leonuri 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Poria, 10 ~ 20 parts, Flos persicae, Radix Curcumae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Flos Inulae 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, propolis 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of beauty folium ginkgo oral liquid, and the preparation method of described beauty folium ginkgo oral liquid comprises the following steps:

A. Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into unguentum;

E. surplus stock is made unguentum;

F. adding dextrin after being mixed by the part by weight of 2:1 with the Folium Ginkgo extract unguentum made by unguentum obtained above is in harmonious proportion rear canned.

In described step a, can get fresh Folium Ginkgo, clean, dry, in 70 DEG C of baking ovens, dry 8-12h, take out and be placed in cooling in drying baker, pulverized 80 mesh sieves with pulverizer, powder is placed in brown, wide-mouth bottle and stores.

In described step b, can get and be made into 60% alcoholic solution; Then fall ginkgo leaf powder in 60% ethanol, in water-bath, be heated to 60 DEG C ~ 70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 60% ethanol 700mL in residue, 60 DEG C ~ 70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution.

In described step c, ginkgo biloba succi first can be used gauze coarse filtration, remove bulky grain precipitation, to improve sucking filtration speed; Sucking filtration instrument is installed, in buchner funnel, adds a small amount of lixiviating solution carry out sucking filtration, after sucking filtration terminates, get filtrate and abandon filtering residue.

In described steps d, distillation, concentrating appts can be installed, containing a large amount of alcoholic solution in sucking filtration liquid, carry out ethanol with distilling apparatus and be condensed into particulate matter or paste object.

In described step e, surplus stock can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.36 time filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, reduce pressure to obtain extractum.

In described step f, add after the extractum that abovementioned steps can be obtained the Folium Ginkgo extract that extractum makes with above-mentioned steps mixes dextrin be in harmonious proportion after canned.

Semen Ginkgo extrac has very strong scavenging free radicals and antioxidation, yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, check melanin grows, skin gloss and elasticity is kept to play no small effect, be applicable to long-term taking, can not damage health.The invention solves the virose shortcoming of Folium Ginkgo; And remaining the beneficiating ingredient of Folium Ginkgo greatly, make it not have work in-process to run off, on the make avoid secondary pollution, is the health product of green health environmental protection completely.Add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulate the metabolism function of human body, improve blood circulation of human body and liver detoxification ability, reach the effect beautifying skin.

Summary of the invention

Detailed description of the invention

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body carry out work, QI-blood circulating regularly freely balances as expensive, if QI and blood is not smooth will produce blood stasis, blood stasis hinders in body, will cause the deterioration of qi-blood circulating further, cause more serious stasis of blood plug, therefore the traditional Chinese medical science take QI and blood as guiding principle, make it smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing, beauty treatment of nourishing blood.Skin speckle basic in the stasis of blood, move back speckle must first blood stasis dispelling, blood stasis dispelling when invigorating blood circulation, invigorate blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood runs thereupon; Blood is keeping of gas, be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy then blood prostration, gas compel then blood walk.QI and blood and then all and.And regulate the flow of vital energy liver, QI invigorating at lung kidney, lung governing skin and hair.Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, and cause face and occur the mottle such as chloasma, freckle, even occur alopecia, alopecia areata.The present invention mainly identifies and corrects the principle treated according to Chinese medicine, collect many doctor chiefs, skim the cream off milk; Based on Chinese medicine to pathogenetic understanding of facial colour spot and Therapeutic Principle, reference is Chinese medicine pharmacological research achievement at all times, the natural Chinese medicine of screening inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulates the metabolism function of human body, improve blood circulation of human body and liver detoxification ability, reach the effect beautifying skin.Semen Ginkgo extrac has very strong scavenging free radicals and antioxidation, and the yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, and check melanin grows, and keeps skin gloss and elasticity to play no small effect.

In Folium Ginkgo, the Mineral Concentrations such as VC, VE, carotene and calcium, phosphorus, boron, selenium is also very abundant, exceedes general fruit and vegetable and edible plant raw material.Biological anti-oxidant is a class material directly and indirectly in body with anti-oxidation function.Containing two class antioxidants--nutrient antioxidant and non-nutritive antioxidant in Folium Ginkgo.The former mainly contains carotene, VC, VE, selenium, zinc, copper etc.; the latter mainly contains ginkgetin, terpene lactones, catechin, Polyphenols etc.; content is also very abundant, and they are protecting body not by having ten important effects in the oxidative damage caused by free radical.Therefore, Folium Ginkgo integrates nutrition, health care, treatment function, the resource that Folium Ginkgo is worth as high nutrition, health care is developed, and this is significant for raising Folium Ginkgo comprehensive utilization ratio.The exploitation of Folium Ginkgo are from the thirties in 20th century, and namely Japan and West Germany start the research of Folium Ginkgo.Along with deepening continuously of modern pharmacological research, find not only containing Flavonoid substances in Folium Ginkgo, and also have the compound such as terpene lactones, phenols, the pharmacological action of their brilliances is familiar with gradually by people.Clinical observation proves, Folium Ginkgo has several effect below: 1, reduce cholesterol levels in blood of human body, prevent arteriosclerosis.To being short of physical strength after middle-aged and elderly people light activity, palpitating speed, chest pain, the effect of being significantly improved such as to feel dizzy.2, reduced blood pressure by increase vascular permeability and elasticity, have good antihypertensive effect.3, eliminate the deposition composition in blood vessel wall, improve hemorheology, promote erythrocyte deformability, reduce blood viscosity, make blood flow unobstructed, can prevention and therapy cerebral hemorrhage and cerebral infarction.Also certain curative effect is had to the senile dementia that arteriosclerosis causes.Gingko leaf preparation and antidiabetic drug share treats diabetes and has good therapeutic effect, can be used for the adjuvant of diabetes.5, the symptom such as abdominal pain in menstruation and sore waist and aching in the waist and the back can obviously be alleviated.6, for the treatment of bronchial asthma, also good therapeutic effect is had.7, reduce level of lipid, reduce freckle, moist skin, beautiful appearance.8, relieving constipation, diuresis, toxin expelling, removing toxic substances.9, climacteric syndrome is improved significantly.

Anemia of pregnant woman of the present invention and child, old man is careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, old people will stop before going too far when taking Folium Ginkgo, and notes periodic detection blood coagulation situation, not blindness long-term taking.For the patient that existing senile sclerosis of blood vessels, blood vessel become fragile, more can not long-term taking, in order to avoid cause cerebral hemorrhage.Have a kind of composition in Folium Ginkgo ginkgoic acid, if dosage excessive, or Time of Administration is long, can damage heart.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.

Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.

Flos Inulae nature and flavor are light flat, and flower, leaf have antiinflammatory, antibacterial action.Root energy promoting flow of QI and blood, flower can removing heat from blood, hemostasis.Superpower healing ability, sterilization convergence wound, administer inflammation, skin sore, corse sweat pore, prevents the generation of cicatrix.The calm skin of energy, improves sensitivity skin quality.There is effect of maintenance cicatrix.The metabolism of skin can be promoted.Especially for the skin of drying, the moisturizing effect of height is had.Radix Curcumae is pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman's stagnated blood epigastric pain caused by emotional factors, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound.

A kind of Chinese medicine material of Flos Campsis, has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature returns liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, control the key medicine of pain in blood also, and nourishing YIN victory very, is stamped and keeps and walk alone, in married woman side multiplex what." Nanning City's medicine will ": the merit having eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting, controls red Hakuri.

Flos Albiziae contains Herba Albiziae glycoside, tannin, resolving stagnation for tranquilization, appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for irritability, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can settling five organs, and will, improving healthy complexion, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.Also have clearing away summer-heat, face-beautifying and spot-removing such as to relieve the effect of alcohol at the effect." herbal warp " is said: " Flos Albiziae energy settling five organs, and will, improving healthy complexion." especially to anemia of pregnant woman, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration is that treatment blood stasis is not fallen apart, and nourishing blood is become silted up the good medicine of invigorating blood circulation

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, and often join the same use of Fructus Mori, fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglyceride accumulation minimizing in liver, hepatocellular degeneration necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultrastructure visible hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue interstitial inflammation habituation.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Eca109), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic.Energy main large migratory arthralgia, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out only.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells vomiting, cold type of pain in abdomen, vomits and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Propolis (bee glue) have the good reputation of " blood vessel street cleaner ", the large quantity research that recent domestic scholar does shows, flavonoid (flavonoid) composition in propolis and various active composition, can improve elasticity and the permeability of blood vessel, vasodilator, removing blood vessel overstocks deposits thing, purify the blood, reduce blood fat, reduce blood viscosity, improve and organize microcirculating state, and there is stronger antioxidation, the effect of scavenging free radicals.Toxicological experiment result shows that propolis is actual innocuous substance, is therefore safe and feasible by long-term taking propolis prevention and therapy hyperlipemia.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, repercussive blood, can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, QI invigorating, the capable hot disease in sky, pestilence miasma, mania and irritation, and married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Specific embodiment 1:

Preparation: get fresh Folium Ginkgo, cleans, dries, and in 70 DEG C of baking ovens, dry 9h (it is fixed that the time looks sample moisture, can 8 ~ 12h), take out and be placed in cooling in drying baker, pulverized 80 mesh sieves with pulverizer, powder is placed in brown, wide-mouth bottle and stores.

Lixiviate: prepare 60% alcoholic solution (get 640mL95% ethanol, 360mL pure water is made into 60% alcoholic solution).Get 100g ginkgo leaf powder in 700mL60% ethanol, be heated to 60 DEG C ~ 70 DEG C, lixiviate 2h in water-bath, every 10min stirs once, by filtered through gauze, add 60% ethanol 700mL in residue, 60 DEG C ~ 70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution.Do parallel laboratory test simultaneously.

Sucking filtration: first use gauze coarse filtration, removes bulky grain precipitation, to improve sucking filtration speed.Install sucking filtration instrument, add a small amount of lixiviating solution and carry out sucking filtration in buchner funnel, owing to containing gelatinous precipitate in Folium Ginkgo, filter paper easily results in blockage, and causes sucking filtration speed to decline, therefore often should change filter paper.After sucking filtration terminates, get filtrate and abandon filtering residue.

Distillation, concentrated: distillation, concentrating appts to be installed, containing a large amount of alcoholic solution in sucking filtration liquid, to carry out ethanol with distilling apparatus and concentrate.A certain amount of ethanol also has bactericidal action, when measuring extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, ethanol is volatilized totally completely.In order to not destroy effective ingredient in extract, bath temperature controls at 60 DEG C ~ 70 DEG C, and the boiling point of 95% ethanol is at about 75 DEG C, therefore distillation speed is slow, and the time is long.Can take simple method, direct heating in water bath, volatilize ethanol in atmosphere, this method shortcoming: can not reclaim ethanol.The extract finally obtained is part precipitation extractum, and color is dark brown viscous thing.

Dry: owing to still containing part ethanol and moisture in concentrated lixiviating solution, adopt boulton process, temperature controls between 60 DEG C ~ 70 DEG C, and utilization increases vacuum and reduces boiling point, the portion of water removed last ethanol and remain.If conditions permit can also adopt freezing and drying lyophilization dry.Except containing except flavonoid and lactone in extract now, also containing a certain amount of impurity.

All the other raw materials are granulated: by all the other raw material Herba Leonuris, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Salviae Miltiorrhizae, Poria, Flos persicae, Radix Curcumae, Fructus Ligustri Lucidi, Flos Inulae, Flos Campsis, Radix Scutellariae, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Flos Albiziae, propolis, Caulis Spatholobi.

Packaging: by the above-mentioned extractum made, the Folium Ginkgo extract good with aforementioned dry in the sun mixes, adds appropriate dextrin and is in harmonious proportion, canned.

Specific embodiment 2:

Pluck the fresh and tender Folium Ginkgo of 1000g, clean, dry, in 70 DEG C of baking ovens, dry 10h, take out and be placed in cooling in drying baker, pulverized 60 mesh sieves with pulverizer, powder is placed in brown, wide-mouth bottle and stores preparation 60% alcoholic solution.Get 1000g ginkgo leaf powder in 7000mL60% ethanol, be heated to 60 DEG C ~ 70 DEG C, lixiviate 2h in water-bath, every 10min stirs once, by filtered through gauze, add 60% ethanol 7000mL in residue, 60 DEG C ~ 70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution.Do parallel laboratory test simultaneously.First use gauze coarse filtration, remove bulky grain precipitation, to improve sucking filtration speed.Install sucking filtration instrument, add a small amount of lixiviating solution and carry out sucking filtration in buchner funnel, owing to containing gelatinous precipitate in Folium Ginkgo, filter paper easily results in blockage, and causes sucking filtration speed to decline, therefore often should change filter paper.After sucking filtration terminates, get filtrate and abandon filtering residue, containing a large amount of alcoholic solution in sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.A certain amount of ethanol also has bactericidal action, when measuring extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, ethanol is volatilized totally completely.In order to not destroy effective ingredient in extract, bath temperature controls at 60 DEG C ~ 70 DEG C, and the boiling point of 95% ethanol is at about 75 DEG C, therefore distillation speed is slow, and the time is long.Can take simple method, direct heating in water bath, volatilize ethanol in atmosphere, this method shortcoming: can not reclaim ethanol.The extract finally obtained is part precipitation extractum, and color is dark brown viscous thing.Owing to still containing part ethanol and moisture in concentrated lixiviating solution, adopt boulton process, temperature controls between 60 DEG C ~ 70 DEG C, utilizes increase vacuum to reduce boiling point, the portion of water removed last ethanol and remain.By all the other raw material Herba Leonuris 500g, Radix Angelicae Dahuricae 500g, Radix Angelicae Sinensis 500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 500g, Radix Salviae Miltiorrhizae 500g, Poria 500g, Flos persicae 500g, Radix Curcumae 500g, Fructus Ligustri Lucidi 500g, Flos Inulae 500g, Flos Campsis 500g, Radix Scutellariae 500g, Radix Paeoniae Alba 500g, Rhizoma Atractylodis Macrocephalae 500g, Flos Albiziae 500g, propolis 500g, Caulis Spatholobi 500g.Put it in 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Merged by above-mentioned two kinds of extracting solution, concentrating under reduced pressure relative density is the filtrate of 1.36 (80 DEG C), reclaims ethanol, and by gained filtrate adjustment proportion to 1.06, reduce pressure to obtain extractum; Then the Folium Ginkgo extract extractum obtained with above-mentioned steps, adds appropriate dextrin and is in harmonious proportion, canned.

Specific embodiment 3:

Pluck 500g Folium Ginkgo, clean, dry, in 70 DEG C of baking ovens, dry 9h, take out and be placed in cooling in drying baker, pulverized 60 mesh sieves with pulverizer, powder is placed in brown, wide-mouth bottle and stores preparation 60% alcoholic solution (get 640mL95% ethanol, 360mL pure water is made into 60% alcoholic solution).Get 500g ginkgo leaf powder in 3500mL60% ethanol, be heated to 60 DEG C ~ 70 DEG C, lixiviate 2h in water-bath, every 10min stirs once, by filtered through gauze, add 60% ethanol 3500mL in residue, 60 DEG C ~ 70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution.Do parallel laboratory test simultaneously.First use gauze coarse filtration, remove bulky grain precipitation, to improve sucking filtration speed.Install sucking filtration instrument, add a small amount of lixiviating solution and carry out sucking filtration in buchner funnel, owing to containing gelatinous precipitate in Folium Ginkgo, filter paper easily results in blockage, and causes sucking filtration speed to decline, therefore often should change filter paper.After sucking filtration terminates, get filtrate and abandon filtering residue.Distillation, concentrating appts are installed, containing a large amount of alcoholic solution in sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.In order to not destroy effective ingredient in extract, bath temperature controls at 60 DEG C ~ 70 DEG C, and the boiling point of 95% ethanol is at about 75 DEG C, therefore distillation speed is slow, and the time is long.The extract finally obtained is part precipitation extractum, and color is dark brown viscous thing.Owing to still containing part ethanol and moisture in concentrated lixiviating solution, adopt boulton process, temperature controls between 60 DEG C ~ 70 DEG C, utilizes increase vacuum to reduce boiling point, the portion of water removed last ethanol and remain.By all the other raw material Herba Leonuris 210g, Radix Angelicae Dahuricae 220g, Radix Angelicae Sinensis 230g, Pseudobulbus Bletillae (Rhizoma Bletillae) 210g, Radix Salviae Miltiorrhizae 220g, Poria 230g, Flos persicae 240g, Radix Curcumae 210g, Fructus Ligustri Lucidi 250g, Flos Inulae 220g, Flos Campsis 210g, Radix Scutellariae 230g, Radix Paeoniae Alba 240g, Rhizoma Atractylodis Macrocephalae 210g, Flos Albiziae 230g, propolis 250g, Caulis Spatholobi 220g.Put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, the Folium Ginkgo extract extractum then obtained with above-mentioned steps, adds appropriate dextrin and is in harmonious proportion, canned.

Pharmacological toxicity is tested

Health product acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: health product of the present invention, containing 0.0365g crude drug/g.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, (interval half an hour) is fed water at twice in one day, each 0.5ml (every ml containing crude drug 0.036g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Long term toxicity test data of the present invention

Chinese medicine of the present invention is through the gastric infusion long-term toxicity test for animals result of 6 months: SD rat is divided into three groups, often organizes 30, male and female half and half (be divided into high, medium and low three dosage groups, often organize 10), wherein first group through gavage to normal saline; Be 0.25g, 2.5g and 12.5g/kg.d to dosage of the present invention through gavage for second group; 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of lovastatin.During administration, observe the evaluation that the indexs such as the clinical manifestation after each treated animal administration, hematology, blood biochemistry, organ coefficient and histopathology carry out drug toxicity respectively.Result of study: the present lovastatin 50mg/kg.d of major toxicity reaction table and 5.0mg group, shows SD rat upon administration and has occurred reaction and the symptoms such as sialorrhea, hair are fluffy, busy, diarrhoea, step, total food ration and losing weight; Blood test display total white blood cells increases to some extent, and Erythrocytes, content of hemoglobin and platelet count obviously decline (the equal <0.05 of P); Blood biochemistry checking display ALT, AST, ALP and CK raise 1 ~ 8 times (the equal <0.05 of P), and creatinine and blood urea nitrogen raise to some extent (the equal <0.05 of P), but do not cause animal dead; There is the Liver and kidney pathological change similar to people in histopathological analysis result display lovastatin 50mg/kg.d group.And all there is not similar reaction in normal saline group and 0.25g, 2.5g and 12.5g/kg.d of the present invention tri-dosage groups and lovastatin 0.5mg/kg.d dosage group during whole administration, at convalescent period viewing duration, occur that the symptom of each treated animal of reaction fades away recovery normal condition.Visible the present invention not only can reduce the toxic and side effects of lovastatin, and the clinical non-toxic of lovastatin can be made to be increased to 5 ~ 25 times (the equal <0.01 of P).

The test of pesticide effectiveness:

1 materials and methods

1.1 materials: animal grouping and modeling, gavage Therapeutic Method

Get female KM kind mice 60, be divided into 6 groups at random, often organize 10.45 days modeling time, 45 days gavage treatment times.White mice is provided by biology department of University Of Qingdao breeding center.

1. normal group: with 10%NaS ₂aqueous solution sloughs back wool, and expose skin 1 piece, area is about 1.5cm × 1.5cm.Lose hair or feathers weekly once, intramuscular injection every day water for injection, 5ml/kg body weight.The depilation area skin situation of change of Continuous Observation mice.After 45 days, stop modeling, every day gavage deionized water 0.6ml.

2. model group: with normal group depilation process, inject 0.4% Progesterone every day, 5ml/kg body weight.Mice is placed in special constraint bucket and fetters by every day, and irradiates mice 1 time, constraint irradiation time 60min, Continuous Observation at the ultraviolet B radiation (UVB) that constraint is 320nm with wavelength simultaneously.After 45 days, stop modeling, every day gavage deionized water 0.6ml.

3. positive controls (XIAOYAO POWDER treatment group, 3.43g/kg): with normal group depilation process, inject 0.4% Progesterone every day, 5ml/kg body weight.Mice is placed in special constraint bucket and fetters by every day, and irradiates mice 1 time, constraint irradiation time 60min, Continuous Observation at the ultraviolet B radiation (UVB) that constraint is 320nm with wavelength simultaneously.After 45 days, stop modeling, every day gavage XIAOYAO POWDER 0.6ml.

4. high dose group of the present invention (14.19g/kg): with normal group depilation process, inject 0.4% Progesterone every day, 5ml/kg body weight.Mice is placed in special constraint bucket and fetters by every day, and irradiates mice 1 time, constraint irradiation time 60min, Continuous Observation at the ultraviolet B radiation (UVB) that constraint is 320nm with wavelength simultaneously.After 45 days, stop modeling, every day gavage compositions 0.9ml.

5. middle dosage group (9.46g/kg) of the present invention: with normal group depilation process, inject 0.4% Progesterone every day, 5ml/kg body weight.Mice is placed in special constraint bucket and fetters by every day, and irradiates mice 1 time, constraint irradiation time 60min, Continuous Observation at the ultraviolet B radiation (UVB) that constraint is 320nm with wavelength simultaneously.After 45 days, stop modeling, every day gavage compositions 0.6ml.

6. low dose group of the present invention (4.73g/kg): with normal group depilation process, inject 0.4% Progesterone every day, 5ml/kg body weight.Mice is placed in special constraint bucket and fetters by every day, and irradiates mice 1 time, constraint irradiation time 60min, Continuous Observation at the ultraviolet B radiation (UVB) that constraint is 320nm with wavelength simultaneously.After 45 days, stop modeling, every day gavage compositions 0.3ml.

2, test method

2.2 skins, liver MDA, SOD, ZnCu-SOD determination of activity adopt test kit to detect MDA, SOD activity, and experiment is carried out to specifications.

The mensuration of 2.3 total SOD (T-SOD) vigor: requirement to specifications, carrying out preliminary experiment, to calculate optimum sample size be 30ul.Successively add the tissue homogenate of reagent 1 ~ 4 and 1%, fully mix with swirl mixing device, put 37 DEG C of waters bath with thermostatic control 40 minutes.Then add developer 2ml to mix, pour in 1cm optical path cuvette after 10 minutes, distilled water returns to zero, wavelength 550nm place colorimetric.

The mensuration of 2.4CuZn-SOD vigor: get the reagent seven that tissue homogenate 0.2ml adds 0.1ml, after fully mixing 1 minute, with 3500-4000 revs/min, centrifugal 15 minutes, gets supernatant and tests with swirl mixing device.Method is with total SOD.

The mensuration of 2.5MDA vigor: requirement to specifications, successively add the tissue homogenate of reagent 1 ~ 3 and 1%, swirl mixing device mixes, and test tube mouth antistaling film is tightened, and stings an aperture, 95 DEG C of water-baths 40 minutes, flowing water cooling after taking out, then 3500 ~ 4000 revs/min, centrifugal 10 minutes, (less than 3000 revs/min centrifugation times need to extend, and object makes precipitation complete).Get supernatant 0.1ml, 532nm place, 1cm optical path, distilled water returns to zero, and colorimetric surveys each pipe absorbance.

2.6HMB45 the PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM of the dermal melanin cell of labelling

1) routine paraffin wax embedded section (5um), dewaxes to water.Distilled water flushing, PBS soaks 5 minutes.2) 3%H2O2 incubated at room 5-10 minute, to eliminate the activity of endogenous peroxydase, PBS rinses, 2 minutes × 3 times.3) 10% Normal Goat Serum is closed, incubated at room 10 minutes, and drip primary antibodie HMB45,4 DEG C are spent the night.4) PBS rinses, 2 minutes × 3 times.Drip the biotin labeling two anti-(1%BSA-PBS dilution) of proper proportion dilution, hatch 10-30 minute for 37 degree; 5) PBS rinses, 2 minutes × 3 times.Drip the Radix Cochleariae officinalis enzyme labelling strepto-avidin (PBS dilution) of proper proportion dilution, hatch 10-30 minute for 37 degree; 6) PBS rinses, 2 minutes * 3 times.Chromogenic reagent (DAB) 5-10 minute.7) tap water fully rinses, and haematoxylin is redyed, and dewater transparent, mounting.Adopt Image-Pro Plus5.0 image analysis system software analysis, the area calculating each group of melanocyte and melanin granule positive expression position and optical density.

The expression of 2.6 dermal melanin cell NOS

1) routine paraffin wax embedded section (5um), dewaxes to water.Distilled water flushing, PBS soaks 5 minutes.2) 3%H2O2 incubated at room 5-10 minute, to eliminate the activity of endogenous peroxydase, PBS rinses, 2 minutes × 3 times.3) 10% Normal Goat Serum is closed, incubated at room 10 minutes, and drip primary antibodie NOS, 4 DEG C are spent the night.4) PBS rinses, 2 minutes × 3 times.Drip the biotin labeling two anti-(1%BSA-PBS dilution) of proper proportion dilution, hatch 10-30 minute for 37 degree; 5) PBS rinses, 2 minutes × 3 times.Drip the Radix Cochleariae officinalis enzyme labelling strepto-avidin (PBS dilution) of proper proportion dilution, hatch 10-30 minute for 37 degree; 6) PBS rinses, 2 minutes × 3 times.Chromogenic reagent (DAB) 5-10 minute.7) tap water fully rinses, and haematoxylin is redyed, and dewater transparent, mounting.Adopt Image-Pro Plus5.0 image analysis system software analysis, the area calculating each group of NOS positive expression position and optical density.

3, experimental data

The mensuration of the total SOD activity of 3.1 skin and statistics

Contrast with blank group, the total SOD activity value of skin of high dose group of the present invention declines, and has significant difference; In XIAOYAO POWDER, the present invention, dosage group low dosage and blank group there are differences.Contrast with model group, XIAOYAO POWDER, high, the middle dosage group of the present invention have extremely significant difference, and there were significant differences for low dose group.In table 1.The total SOD activity decrease of mouse model skin that visible ultraviolet light+Progesterone method is set up, it is active that XIAOYAO POWDER, the high, medium and low dosage of the present invention all can improve the total SOD of skin, and wherein XIAOYAO POWDER, high, the middle dosage treatment of the present invention have and act on extremely significantly.

The change (x ± s ,/mg albumen) of the total SOD activity of table 1 skin

Note: compare with blank group, * P<0.05, * * P<0.01; Compare with model group, ★ P<0.05, ★ ★ P<0.01.Liver F=4.624, skin F=5.010

The mensuration of 3.2 liver ZuCu-SOD activity and statistics

Contrast with blank group, liver ZuCu-SOD activity value of low dose group of the present invention declines, and has significant difference.Contrast with model group, treatment XIAOYAO POWDER, high dose group of the present invention have significant difference.In table 2.Chloasma mouse model liver ZuCu-SOD activity decrease that visible chronic constriction+ultraviolet+Progesterone method is set up, it is active that XIAOYAO POWDER, the high, medium and low dosage of the present invention all can improve liver ZuCu-SOD, and wherein XIAOYAO POWDER, high dose tool of the present invention have significant therapeutic effect.

The mensuration of 3.3 skin ZuCu-SOD activity and statistics

Decline with skin ZuCu-SOD activity value of blank group edition with parallel text invention low dose group, there is significant difference.Contrast with model group, in treatment XIAOYAO POWDER, the present invention, dosage group has significant difference.In table 2.Chloasma mouse model skin ZuCu-SOD activity decrease that visible chronic constriction+ultraviolet+Progesterone method is set up, it is active that XIAOYAO POWDER, the high, medium and low dosage of the present invention all can improve skin ZuCu-SOD, and wherein in XIAOYAO POWDER, compositions, dosage tool has significant therapeutic effect.

The change (x ± s ,/mg albumen) of table 2ZuCu-SOD activity

Note: compare with blank group, * P<0.05, * * P<0.01; Compare with model group, ★ P<0.05, ★ ★ P<0.01.Liver F=3.395, skin F=6.804.

3.4HMB45 the dermal melanin cell pathology morphological observation of labelling

3.4.1HMB45 the whole observation of the dermal melanin cell of labelling

Normal group: squamous epithelial cancer is more poor, is made up of the basal cell of marshalling and spine cell, altogether layer 2-3, and there is a small amount of cutin on surface.See hair follicle in corium, sebaceous gland is connected with epidermis, has no sweat gland.Subcutaneus adipose tissue has no special.Almost have no melanocyte in HMB 45 labelling epidermis, in hair follicle, sebaceous gland basal cell, see a small amount of melanocyte.

The melanin positive cell showed increased of model group: HMB 45 labelling, have pole significant difference with blank group, cluster is distributed in hair follicle basal cell group, in strong positive reaction, also see the single melanocyte being dispersed in distribution in epidermal basal cell and prickle cell layer, companion cell core increases and core moves.Epidermis cell number increases, and local is in verrucous hyperplasia.Treatment group: show substantially same model group, melanin positive cell reduces, there were significant differences with model group, and the liver energy stagnation type chloasma mouse model dermal melanin cell compared with normal mice that prompting chronic constriction+ultraviolet+Progesterone method is set up significantly is increased, and XIAOYAO POWDER and compositions have therapeutical effect.

The change of melanin granule positive area in the mouse skin melanocyte of table 3HMB45 labelling

Note: compare with blank group, * P<0.05, * * P<0.01; ★ P<0.05 is compared, ★ ★ P<0.01 with model group.The F=11.896 of the F=14.096 of the F=61.170 of positive area, IOD, MOD.

As seen from Table 3:

(1) in the mouse skin melanocyte of model group HMB45 labelling, the positive area compared with normal group of melanin granule significantly raises (P<0.01), the each dosage treatment group of XIAOYAO POWDER, compositions has downward trend, wherein XIAOYAO POWDER treatment group and compositions low dose group decline highly significant (P<0.01), combines object height, the downward trend of middle dosage group is not obvious.

(2) in the mouse skin melanocyte of model group HMB45 labelling, the IOD compared with normal group of melanin granule significantly raises (P<0.01), XIAOYAO POWDER, each dosage treatment group of the present invention have downward trend, wherein XIAOYAO POWDER treatment group and high dose group decline highly significant (P<0.01) of the present invention.

(3) in the mouse skin melanocyte of model group HMB45 labelling, the MOD compared with normal group of melanin granule significantly raises (P<0.01), XIAOYAO POWDER, each dosage treatment group of the present invention have downward trend, wherein XIAOYAO POWDER treatment group decline highly significant (P<0.01), in the present invention, dosage group declines obviously (P<0.05).The downward trend of compositions high and low dose group is not obvious.

In sum, in the mouse skin melanocyte of model group HMB45 labelling, the positive area of melanin granule, IOD, MOD all have significant rising, XIAOYAO POWDER, each dosage treatment group of the present invention have downward trend, but in general, the effect of high dose group of the present invention is the most remarkable, all having significant reducing effect to positive area, IOD, MOD, is secondly dosage group in the present invention.

Conclusion: Semen Ginkgo extrac has very strong scavenging free radicals and antioxidation, the yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, and check melanin grows, and keep skin gloss and elasticity to play no small effect.Add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulate the metabolism function of human body, improve blood circulation of human body and liver detoxification ability, reach the effect beautifying skin.

Clinical trial data:

1, because of visceral dysfunction, the pigmented lesions such as the chloasma faciei caused, chloasma hepaticum adopt oral liquid of the present invention to follow the tracks for the treatment of.Because of visceral dysfunction, the pigmented lesion 100 such as the chloasma faciei caused, chloasma hepaticum example, wherein, male 25 example, women 75 example, age 16-52 year, patient, based on person between twenty and fifty, is many with women.

Clinical symptoms: face is partially dark, the long-term length of face has the pigmented lesion such as chloasma, chloasma hepaticum, and some is also with pox, skin sore, acne etc.Patient has dizziness, Mental fatigue timidness due to deficiency of QI, and the tired lazyness speech of limb, loss of appetite, the symptoms such as insomnia, most of patients has constipation phenomenon.Wherein 15 routine patients have depilation phenomenon, have 4 routine patients to occur alopecia areata.Patient used the dermopathic medicine of existing multiple treatment more, DeGrain, or invalid.

Tcm diagnosis is thought, this disease is stagnant in internal organs, and zang-fu disharmony, qi depression to blood stasis, has influence on the QI-blood circulation function of internal organs.Its inherent zang-fu disharmony be because of, deficiency of both QI and blood, the stasis of blood are stagnant is not freely fruit, treatment answer depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation.

Therapeutic Method: oral liquid of the present invention, Semen Ginkgo extrac has very strong scavenging free radicals and antioxidation, yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, and check melanin grows, and keep skin gloss and elasticity to play no small effect.Every day 3 times, each 6-10 gram 10 days is a course for the treatment of, and usual 1-3 is effective for a course for the treatment of, and pertinacious disease needs 4-5 the course for the treatment of, also can various dosage form be used alternatingly.

Therapeutic effect: after 1-3 the course for the treatment of of taking medicine, perusal facial colour spot from depth to shallow, eliminate gradually by the sixth of the twelve Earthly Branches, and the healing patient that clinical symptoms disappears completely is 41 people, cure rate 41%; Perusal facial colour spot is obviously desalinated the sixth of the twelve Earthly Branches, but does not eliminate completely, and the effective patient that clinical symptoms disappears substantially is 45 examples, obvious effective rate 45%, and this part patient continues to take medicine; Perusal facial colour spot is slightly desalinated, patient 10 example that clinical symptoms has part to reduce, effective percentage 10%, and this part patient continues to take medicine; After 5 courses for the treatment of, symptom still unalterable patient is 4 examples, inefficiency 4%.After 3-4 the course for the treatment of, the patients symptomatic with alopecia alleviates, and the alopecia areata place with patients with alopecia areata starts to grow hair.In tracking treatment patient, have no obvious adverse effect and toxic and side effects, after 9 courses for the treatment of, do not find that there is the phenomenon of gastrointestinal upset.Follow up a case by regular visits to healing patient and have no recurrence in 2 years.

2, because of menoxenia, the pigmented pathological changes of the chloasma faciei caused, butterfly full of stains or spots isochrome element

Adopt oral liquid of the present invention follow the tracks for the treatment of female patient 100 example, age 25-50 year, suffer from history 1-30, clinical symptoms: face is partially dark, face is long-term long the pigmented lesion such as chloasma, butterfly spot, with menoxenia, pass through smooth, have block, dysmenorrhea through color is dark red.Patient has Deficiency and coldness of spleen and stomach, lustreless complexion and dark and gloomy, and face has the pigmented lesion such as chloasma, butterfly spot, and most of patients has constipation phenomenon.Patient used the dermopathic medicine of existing multiple treatment more, DeGrain, or invalid.Tcm diagnosis is thought, this disease is stagnant in internal organs, and zang-fu disharmony, qi depression to blood stasis, has influence on the QI-blood circulation function of internal organs.Its inherent zang-fu disharmony be because of, deficiency of both QI and blood, the stasis of blood are stagnant is not freely fruit, and treatment answers depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver to dive bright, consumer product dredge stasis, loosening bowel to relieve constipation, promoting the circulation of QI to relieve pain.The present invention has not only used Folium Ginkgo scavenging free radicals and antioxidation, add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulates the metabolism function of human body, improve blood circulation of human body and liver detoxification ability, reach the effect beautifying skin.

Therapeutic Method: medicine is oral liquid of the present invention.Semen Ginkgo extrac is concentrated granular shape, there is very strong scavenging free radicals and antioxidation, yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, and check melanin grows, and keep skin gloss and elasticity to play no small effect.Each 6-10 gram 10 days is a course for the treatment of, and usual 1-3 is effective for a course for the treatment of, and pertinacious disease needs 4-5 the course for the treatment of, also can various dosage form can be used alternatingly.

Therapeutic effect: take medicine after 1-3 the course for the treatment of, facial colour spot from depth to shallow, is eliminated gradually, the healing patient that clinical symptoms disappears completely is 34 people, cure rate 34%; Facial colour spot is shallow by being deep to, and does not eliminate completely, and the effective patient that clinical symptoms disappears substantially is 41 examples, obvious effective rate 41%, and this part patient continues to take medicine; Facial colour spot slightly shoals, effective patient 12 example that clinical symptoms has part to reduce, effective percentage 12%, and this part patient continues to take medicine; After 5 courses for the treatment of, symptom still unalterable patient is 13 examples, inefficiency 13%.Cure in patient in tracking treatment and have no obvious adverse effect and toxic and side effects, after 9 courses for the treatment of, do not find that there is the phenomenon of gastrointestinal upset.Follow up a case by regular visits to healing patient and have no recurrence in 2 years.

Specific embodiment 1: the Qin, female, 28 years old, married, in October, 2009 goes to a doctor.Tell and go out without face under obvious inducement: existing brown spot, chloasma hepaticum 2 years, and deepen gradually to expand.Man and wife often bickers, and readme oneself temper is large, once repeatedly takes medicine, and in conjunction with the various QUBAN SHUANG of external, does not all obtain good therapeutic effect.Time medical, seeing that dim complexion is taupe, is very with two outsides, two cheeks, in dark-grey brown, pachylosis, superficial, without obvious subjective symptoms, lose heart, weak, waist soreness, indigestion and loss of appetite, two side of body distensions, menstrual period increase the weight of, light red tongue, while there is tooth to print, white and thin fur, stringy and thready pulse, card belongs to incoordination between the liver and spleen liver qi stagnation type.Give oral liquid treatment of the present invention, treat after 1 month, chloasma faciei, chloasma hepaticum area obviously subtracts light, and plaque area reduces, and the comparatively front smooth exquisiteness of face, treatment is after 3 months continuously, and skin of face is ruddy, is rich in gloss, and readme temper starts gentle.Chloasma hepaticum disappears completely.Chloasma slowly subtracts light.Follow up a case by regular visits to and have no recurrence in 3 years.

Specific embodiment 2: Qiu, 35 years old.Leave over cyasma on the face after fertility, readme is felt out of one's plate, and large stretch of chloasma hepaticum occurs, goes to a doctor in June, 2010.Inquiry time medical: its menstrual cycle is normal, menstrual period 4 ~ 6d, through measure on the low side, color is dim, time folder stasis of blood block, fore udder distending pain of passing through, time have soreness of the waist and knees, fall asleep difficult, two is just normal.Look into: visible pregnant mottle of having one's face covered with, forehead, two cheeks and lip Zhou Juncheng patch.Cheek has chloasma hepaticum, and the colour of skin is pitch-dark.Pale tongue has petechia, white and thin fur, hesitant pulse.Dialectical genus: the network stasis of blood of suffering from a deficiency of the kidney hepatic depression and blood deficiency.With Ginkgo oral liquid treatment of the present invention, treat after 1 month and also have dissipation, menorrhagia through the swollen logical alleviation of fore udder, body of the tongue petechia.For another example rule treatment 2 months by law: menstrual blood volume recovers normal, fore udder no longer distending pain of passing through, sleep is also improved.Look into: patient face brown patch, chloasma hepaticum, cyasma dissipate substantially, and body of the tongue is light red, faint and stringy pulse.Follow up a case by regular visits to and do not have chloasma again in 2 years, chloasma hepaticum is newborn, and the colour of skin starts to bleach, and is rich in gloss.

Claims (9)

1. a beauty folium ginkgo oral liquid, it is characterized in that, described beauty folium ginkgo oral liquid is made up of the crude drug of following parts by weight: Folium Ginkgo 10 ~ 30 parts, Herba Leonuri 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, 10 ~ 15 parts, Poria, 10 ~ 15 parts, Flos persicae, Radix Curcumae 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Flos Inulae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, propolis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts.

2. a beauty folium ginkgo oral liquid, it is characterized in that, described beauty folium ginkgo oral liquid is made up of the crude drug of following parts by weight: Folium Ginkgo 10 ~ 30 parts, Herba Leonuri 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Poria, 10 ~ 20 parts, Flos persicae, Radix Curcumae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Flos Inulae 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, propolis 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts.

3. a preparation method for beauty folium ginkgo oral liquid as claimed in claim 1 or 2, it is characterized in that, the preparation method of described beauty folium ginkgo oral liquid comprises the following steps:

A. Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into unguentum;

E. surplus stock is made unguentum;

F. adding dextrin after being mixed with the Folium Ginkgo extract unguentum made by unguentum obtained above is in harmonious proportion rear canned.

4. the preparation method of beauty folium ginkgo oral liquid according to claim 3, it is characterized in that: in described step a, get fresh Folium Ginkgo, clean, dry, in 70 DEG C of baking ovens, dry 8-12h, taking-up is placed in cooling in drying baker, and pulverized 80 mesh sieves with pulverizer, powder is placed in brown, wide-mouth bottle and stores.

5. beauty folium ginkgo oral liquid preparation method according to claim 3, is characterized in that: in described step b, gets the alcoholic solution being made into 60%; Then get ginkgo leaf powder and put into 60% ethanol, be heated to 60 DEG C ~ 70 DEG C, lixiviate 2h in water-bath, every 10min stirs once, by filtered through gauze, add 60% ethanol 700mL in residue, 60 DEG C ~ 70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution.

6. the preparation method of beauty folium ginkgo oral liquid according to claim 3, is characterized in that: in described step c, ginkgo biloba succi is first used gauze coarse filtration, removes bulky grain precipitation, to improve sucking filtration speed; Sucking filtration instrument is installed, in buchner funnel, adds a small amount of lixiviating solution carry out sucking filtration, after sucking filtration terminates, get filtrate and abandon filtering residue.

7. the preparation method of beauty folium ginkgo oral liquid according to claim 3, is characterized in that: in described steps d, installs distillation, concentrating appts, containing a large amount of alcoholic solution in sucking filtration liquid, carries out ethanol be condensed into unguentum with distilling apparatus.

8. the preparation method of beauty folium ginkgo oral liquid according to claim 3, is characterized in that: in described step e, surplus stock is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, is merged by 2 extracting solution and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.36 time filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, reduce pressure to obtain unguentum.

9. the preparation method of beauty folium ginkgo oral liquid according to claim 3, is characterized in that: in described step f, adds dextrin be in harmonious proportion canned afterwards with the Folium Ginkgo extract unguentum that above-mentioned steps makes after fully being mixed by unguentum obtained in step e.